{"id":43813,"date":"2024-06-02T01:19:23","date_gmt":"2024-06-01T17:19:23","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43813"},"modified":"2024-06-03T19:48:06","modified_gmt":"2024-06-03T11:48:06","slug":"928473c9cb","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43813","title":{"rendered":"BMC Med.|\u592a\u79c0\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u4e0e3\u4e07+\u4e2aeQTL\u6570\u636e\u78b0\u649e\u51fa\u600e\u6837\u7cbe\u5f69\u7684\u706b\u82b1\uff1f\u56db\u5ddd\u5927\u5b66\u534e\u897f\u533b\u9662\u9648\u6c38\u5e73\u56e2\u961fshow\u7ed9\u4f60\u770b\uff01"},"content":{"rendered":"
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\"BMC<\/section>\n
<\/o:p><\/span><\/section>\n
\u4eca\u5929\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u7684\u6587\u7ae0\u901a\u8fc7<\/span>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316<\/span>\uff08Mendelian randomization, MR\uff09<\/span>\u5206\u6790<\/span>\u7ed3\u5408<\/span>\u8868\u8fbe\u91cf\u6027\u72b6\u4f4d\u70b9<\/span>\uff08expression quantitative trait loci, eQTL\uff09\u7684\u52a9\u529b\uff0c\u66f4\u7cbe\u51c6\u5730\u5b9a\u4f4d\u4e86\u836f\u7269\u4f5c\u7528\u7684\u9776\u70b9\uff0c\u7814\u7a76\u8005\u4e0d\u4ec5\u8bc6\u522b\u4e86\u6f5c\u5728\u7684\u836f\u7269\u9776\u6807\uff0c\u8fd8\u901a\u8fc7<\/span>\u836f\u7269\u518d\u5229\u7528\u7b56\u7565<\/span>\u53d1\u73b0\u4e86\u73b0\u6709\u836f\u7269\u7684\u65b0\u9002\u5e94\u75c7\uff0c\u6587\u7ae0\u662f\u7531\u56db\u5ddd\u5927\u5b66\u534e\u897f\u533b\u9662\u9648\u6c38\u5e73\u8bfe\u9898\u7ec4\u8054\u5408\u534e\u897f\u57fa\u6cd5\u5b66\u9662\u738b\u794e\u8bfe\u9898\u7ec4\u5171\u540c\u9020\u5c31\u3002<\/span>MR<\/span>\u662f\u4e00\u79cd\u5de7\u5999\u5730\u5229\u7528\u81ea\u7136\u53d1\u751f\u7684\u9057\u4f20\u53d8\u5f02\u4f5c\u4e3a\u63a2\u7a76\u56e0\u679c\u5173\u7cfb\u7684\u5de5\u5177\u3002\u800c<\/span>eQTL<\/span>\u5219\u76f8\u5f53\u4e8e\u4e00\u5f20\u7cbe\u7ec6\u7684\u57fa\u56e0\u8c03\u63a7\u5730\u56fe\uff0c\u5b83\u63ed\u793a\u4e86\u57fa\u56e0\u53d8\u5f02\u5982\u4f55\u8c03\u63a7\u57fa\u56e0\u8868\u8fbe\u7684\u5965\u79d8\u3002\u8fd9\u5f20\u5730\u56fe\u5df2\u7ecf\u6210\u4e3a\u5168\u7403\u8303\u56f4\u5185\u5173\u8054\u7814\u7a76\uff08genome-wide association studies, GWAS\uff09\u7684\u5f97\u529b\u52a9\u624b\uff0c\u6307\u5f15\u7740\u7814\u7a76\u4eba\u5458\u5728\u836f\u7269\u9776\u70b9\u53d1\u73b0\u7684\u65c5\u9014\u4e0a\uff0c\u63a2\u7d22\u591a\u79cd\u590d\u6742\u75be\u75c5\u7684\u6df1\u5c42\u6b21\u673a\u5236<\/span>\uff08\u662f\u4e0d\u662f\u770b\u5230\u8fd9\u91cc\u89c9\u5f97\u597d\u590d\u6742\uff0c\u6709\u79cd\u671b\u800c\u5374\u6b65\u7684\u611f\u89c9\uff1f\u6ca1\u5173\u7cfb\u54e6\uff0c\u5c0f\u8c37\u53ef\u4ee5\u5e2e\u4f60\u5feb\u901f\u514b\u670d\u56f0\u96be\uff0c\u52a9\u529b\u4f60\u5feb\u901f\u53d1\u8868\u9ad8\u8d28\u91cf\u6587\u7ae0\u54e6\uff01\uff09<\/span>\u3002\u5c0f\u4e91\u5c31\u7ed9\u4f60\u4ecb\u7ecd\u8fd9\u7bc7\u6587\u7ae0\u7684\u7cbe\u5999\u4e4b\u5904\uff01<\/span>
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1\u3001\u6587\u7ae0\u4f7f\u7528\u4e86\u6765\u81ea<\/span>eQTLGen\u548cPsychENCODE<\/span>\u8840\u6db2\u548c\u5927\u8111\u7ec4\u7ec7\u7684<\/span>3\u4e07+\u4e2aeQTLs\u6570\u636e\uff0c\u5927\u5927\u589e\u52a0\u4e86\u7814\u7a76\u7ed3\u679c\u7684\u53ef\u9760\u7a0b\u5ea6<\/span>\uff1b<\/span><\/span><\/section>\n
2\u3001\u7814\u7a76\u4f7f\u7528<\/span>MR\u5206\u6790\uff0c\u51cf\u5c11\u6df7\u6742\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u63d0\u9ad8\u4e86\u56e0\u679c\u63a8\u65ad\u7684\u51c6\u786e\u6027<\/span>\u3002<\/span><\/span><\/section>\n
3\u3001\u6587\u7ae0\u4e2d\u7684\u836f\u7406\u5b66\u9a8c\u8bc1\u5b9e\u9a8c\u589e\u5f3a\u4e86MR\u5206\u6790\u7ed3\u679c\u7684<\/span>\u53ef\u4fe1\u5ea6<\/span>\uff0c\u7279\u522b\u662f\u5728\u7ec6\u80de\u6a21\u578b\u4e2d\u5bf9R788\u548cAMX\u4e24\u79cd\u836f\u7269\u7684\u7597\u6548\u8fdb\u884c\u4e86\u9a8c\u8bc1\u3002<\/span><\/span><\/section>\n
\u8fd9\u7bc7\u6587\u7ae0\u7cbe\u5999\u5730\u7ed3\u5408\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u4e0e\u836f\u7269\u518d\u5229\u7528\u7b56\u7565\uff0c\u5f00\u8f9f\u4e86\u4e00\u6761\u9ad8\u6548\u4e14\u521b\u65b0\u7684\u7814\u7a76\u8def\u5f84\u3002\u6709\u4e86\u8fd9\u6837\u7684\u601d\u8def\uff0c\u4f55\u6101\u53d1\u4e0d\u4e86\u9ad8\u5206\u6587\u7ae0\u5462\u3002\u4f60\u662f\u4e0d\u662f\u4e5f\u60f3\u8981\u53d1\u8868\u81ea\u5df1\u7684\u4f18\u79c0\u8bba\u6587\uff0c\u5982\u679c\u4f60\u6709\u4efb\u4f55\u60f3\u6cd5\u90fd\u53ef\u4ee5\u4e3b\u52a8\u6765\u627e\u5c0f\u4e91\u4ea4\u6d41\u54e6\uff0c\u5982\u679c\u6682\u65f6\u6ca1\u6709\u60f3\u6cd5\u4e5f\u6ca1\u6709\u5173\u7cfb\uff0c\u73b0\u5728\u626b\u7801\u6dfb\u52a0\u5c0f\u4e91<\/span>\u5fae\u4fe1\uff0c\u624b\u628a\u624b\u5e26\u4f60\u53d1\u8868\u9ad8\u5206\u8bba\u6587\u54e6\uff01<\/span>  <\/span><\/section>\n
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\"BMC<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


\n<\/span><\/section>\n
\"BMC<\/span><\/section>\n
\u9898\u76ee\uff1aTBK1\uff0c\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u7684\u4f18\u5148\u836f\u7269\u518d\u5229\u7528\u9776\u70b9\uff1a\u6765\u81ea\u53ef\u6210\u836f\u57fa\u56e0\u7ec4\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u548c\u4f53\u5916\u836f\u7406\u5b66\u9a8c\u8bc1\u7684\u8bc1\u636e<\/span><\/section>\n
\u6742\u5fd7\uff1aBMC Medicine<\/span><\/section>\n
\u5f71\u54cd\u56e0\u5b50\uff1aIF=9.3<\/span><\/section>\n
\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e743\u6708<\/span><\/section>\n
\u7814\u7a76\u80cc\u666f<\/span><\/strong><\/span><\/section>\n
\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u662f\u4e00\u79cd\u81f4\u547d\u7684\u8fd0\u52a8\u795e\u7ecf\u5143\u75be\u75c5\uff0c\u76ee\u524d\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7597\u7b56\u7565\u3002\u7531\u4e8eALS\u7684\u53d1\u75c5\u673a\u5236\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\uff0c\u5bfc\u81f4\u6cbb\u7597\u624b\u6bb5\u7684\u53d1\u5c55\u9762\u4e34\u91cd\u5927\u6311\u6218\u3002\u56e0\u6b64\uff0c\u836f\u7269\u518d\u5229\u7528\uff0c\u5373\u53d1\u73b0\u73b0\u6709\u836f\u7269\u7684\u65b0\u9002\u5e94\u75c7\uff0c\u4e3aALS\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u79cd\u5feb\u901f\u4e14\u6210\u672c\u6548\u76ca\u9ad8\u7684\u6f5c\u5728\u9014\u5f84\u3002<\/span><\/section>\n
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\u6570\u636e\u6765\u6e90<\/span><\/strong><\/span><\/section>\n\n\n\n\n\n
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\u6570\u636e\u5e93\/\u7f51\u7ad9<\/span><\/section>\n<\/td>\n
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\u6570\u636e\u7c7b\u578b<\/span><\/section>\n<\/td>\n
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\u8be6\u7ec6\u4fe1\u606f<\/span><\/section>\n<\/td>\n<\/tr>\n
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eQTLGen<\/span><\/section>\n<\/td>\n
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cis-eQTL\u6570\u636e<\/span><\/section>\n<\/td>\n
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31,684 \u4e2a\u8840\u6db2\u548c\u5916\u5468\u8840\u5355\u6838\u7ec6\u80de\u6837\u672c<\/span><\/section>\n<\/td>\n<\/tr>\n
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PsychENCODE<\/span><\/section>\n<\/td>\n
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cis-eQTL\u6570\u636e<\/span><\/section>\n<\/td>\n
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679\u540d\u5065\u5eb7\u5bf9\u7167\u6837\u672c\uff1b497 \u540d\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u3001172 \u540d\u53cc\u76f8\u60c5\u611f\u969c\u788d\u60a3\u8005\u300131 \u540d\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u60a3\u8005\u3001 8 \u540d\u60c5\u611f\u969c\u788d\u60a3\u8005<\/span><\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n\u7814\u7a76\u601d\u8def<\/span><\/strong><\/span><\/section>\n
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\u7814\u7a76\u7ed3\u679c<\/span><\/strong><\/span><\/section>\n
1\u3001\u57fa\u56e0\u8868\u8fbe\u4e0eALS\u9884\u540e\u7684MR\u5206\u6790<\/span><\/strong><\/span><\/section>\n
\u7814\u7a76\u8005\u4f7f\u7528\u4f4d\u4e8eTSS\u00b1100kb\u5185\u4e14\u6ee1\u8db3FDR<0.05\u7684SNPs\u7684\u663e\u8457\u9608\u503c\uff0c\u5728\u8840\u6db2\u548c\u8111\u4e2d\u53d1\u73b0\u4e868\u4e2a\u72ec\u7279\u7684\u6f5c\u5728\u836f\u7269\u9776\u70b9\uff08TNFSF13\u3001CD68\u3001TNFSF12\u3001TBK1\u3001RESP18\u3001GDF9\u3001PTPRN\u548cGPX3\uff09\u3002\u901a\u8fc7<\/span>MR\u5206\u6790<\/span>\u8bc6\u522b\u51fa\u4e0eALS\u98ce\u9669\u663e\u8457\u76f8\u5173\u7684\u57fa\u56e0\uff0c\u6bd4\u5982\u5728\u8840\u6db2\u4e2dTNFSF13\u548cCD68\u4e0eALS\u98ce\u9669\u964d\u4f4e\u76f8\u5173\uff1b\u5728\u5927\u8111\u4e2d\uff0cRESP18\u7684\u8868\u8fbe\u4e0eALS\u7684\u98ce\u9669\u76f8\u5173\u3002<\/span>\u5171\u5b9a\u4f4d\u5206\u6790<\/span>\u7684\u6761\u5f62\u56fe\u5219\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86MR\u5206\u6790\u4e2d\u5f97\u5230\u7684\u663e\u8457\u57fa\u56e0\u4e0eALS\u7684GWAS\u4fe1\u53f7\u7684\u5171\u5b9a\u4f4d\u5173\u7cfb\uff08\u56fe1\uff09\u3002<\/span>    <\/span><\/o:page><\/section>\n
\"BMC<\/span><\/section>\n
\u56fe1 \u57fa\u56e0\u8868\u8fbe\u4e0eALS\u9884\u540e\u7684MR\u5206\u6790<\/span><\/section>\n
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2\u3001AMX\u548cR788\u4f5c\u4e3a\u9776\u5411TBK1\u7684\u6f5c\u5728\u6291\u5236\u5242\u7684\u9274\u5b9a<\/span><\/strong><\/span><\/section>\n
\u7814\u7a76\u8005\u91c7\u7528<\/span>\u7ec6\u80de\u70ed\u8f6c\u79fb\u5b9e\u9a8c\uff08CETSA\uff09\uff0c<\/span>\u53d1\u73b0AMX\u5bf9\u7ec6\u80de\u88c2\u89e3\u7269\u4e2dTBK1\u70ed\u7a33\u5b9a\u6027\u7684\u5f71\u54cd\u572837-60\u2103\u7684\u6e29\u5ea6\u8303\u56f4\u5185\u8868\u73b0\u51fa\u9002\u5ea6\u7684\u5dee\u5f02\u3002\u901a\u8fc7\u5728\u7ebf\u6570\u636e\u5e93<\/span>LINCS\u3001DrugBank\u548cBindingDB<\/span>\uff0c\u7814\u7a76\u8005\u53d1\u73b0R406\u4e0eTBK1\u5177\u6709\u5f88\u5f3a\u7684\u4eb2\u548c\u529b\uff08\u56fe2A\uff09\u3002\u5df2\u53d1\u8868\u7684\u5171\u6676\u4f53\u7ed3\u6784\u8868\u660e\uff0cR406\u5d4c\u5165\u4e86SYK\u6fc0\u9176\u7ed3\u6784\u57df\uff0c\u5e76\u5360\u636e\u4e86ATP\u7ed3\u5408\u53e3\u888b\uff08\u56fe2B\uff09\uff1b\u4e14R788\u548cR406\u90fd\u5f88\u597d\u5730\u9002\u5408\u4e8eTbk1\u6fc0\u6d3b\u533a\uff08\u56fe2C,D\uff09\u3002\u9884\u6d4b\u7684R788-TBK1\u76f8\u4e92\u4f5c\u7528\u8868\u73b0\u4e3a\u6c22\u952e\u3001\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u3001\u5364\u7d20\u952e\u548c\u76d0\u6865\uff08\u56fe2E\uff09\u3002<\/span>    <\/span><\/o:page><\/section>\n
\"BMC<\/span><\/section>\n
\u56fe2 AMX\u548cR788\u4f5c\u4e3a\u9776\u5411TBK1\u7684\u6f5c\u5728\u6291\u5236\u5242\u7684\u9274\u5b9a<\/span><\/section>\n
3\u3001R788\u548cAMX\u6291\u5236MSA-2\u8bf1\u5bfc\u7684cGAS\/STING\u6d3b\u6027<\/span><\/strong><\/section>\n
MSA-2\u901a\u8fc7Tbk1\/irf3\u8f74\u548cIKK\u03b5\/NF-\u04a1B\u8f74\u6fc0\u6d3bcGAS\/STING\u901a\u8def\uff08\u56fe3A\uff09\u3002\u7814\u7a76\u8005\u53d1\u73b0R788\u6216AMX\u5bf9CCK-8\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\u5448\u6d53\u5ea6\u4f9d\u8d56\u5173\u7cfb\uff08\u56fe3B,C\uff09<\/span>WB<\/span>\u7ed3\u679c\u663e\u793a\uff0cR788\u5bf9TBK1\/IRF3\u4fe1\u53f7\u901a\u8def\u4e2d\u7684TBK1\u5177\u6709\u7279\u5f02\u6027\u6291\u5236\u4f5c\u7528\u3002\u800cAMX\u964d\u4f4e\u4e86p-p65\u548cp-IRF3\u7684\u6c34\u5e73\uff0c\u540c\u65f6\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e86TBK1\u7684\u78f7\u9178\u5316\uff08\u56fe3D-F\uff09\u3002\u7814\u7a76\u8005\u8fd8\u53d1\u73b0R788\u53ef\u4ee5\u6709\u6548\u5730\u6291\u5236IFNB\u3001TNFA\u548cIL-6\u7684\u8bf1\u5bfc\uff0cAMX\u6709\u6548\u964d\u4f4e\u4e86IFNB\u548cIL-6\u6c34\u5e73\uff08\u56fe3G-L\uff09\u3002<\/span>    <\/span><\/o:page><\/section>\n
\"BMC<\/span><\/section>\n
\u56fe3 R788\u548cAMX\u6291\u5236MSA-2\u8bf1\u5bfc\u7684cGAS\/STING\u6d3b\u6027<\/span><\/section>\n
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\u7814\u7a76\u8005\u901a\u8fc7<\/span>WB<\/span>\u89c2\u5bdf\u5230\uff0c\u8f6c\u67d3TDP-43\u548cSOD1\u76f8\u5173\u8d28\u7c92\u7684\u7ec4\u522b\u4e2dp-TBK1\u7684\u6c34\u5e73\u6709\u6240\u589e\u52a0\uff08\u56fe4A\uff09\uff1b\u5e94\u7528\u5f3a\u529b\u9709\u7d20\u8bf1\u5bfc\u7cfb\u7edf\u5728NSC-34\u7ec6\u80de\u4e2d\u8868\u8fbeTDP43\u548cQ331K\u7a81\u53d8\u8d28\u7c92\u540e\uff0cp-TBK1\u548cp-IRF3\u88abR788\u663e\u8457\u6291\u5236\uff08\u56fe4B\uff09\u3002<\/span>RT-qPCR<\/span>\u6570\u636e\u663e\u793a\uff0cR788\u548cAMX\u6291\u5236\u4e86\u5728\u8fc7\u5ea6\u8868\u8fbeTDP-43 WT\/Q331K\u6216SOD1 WT\/G93A\u7684NSC-34\u7ec6\u80de\u4e2d\u6d4b\u8bd5\u7684\u5927\u591a\u6570\u4e0b\u6e38cGAS\/STING\u6548\u5e94\u7269\u7684\u8868\u8fbe(\u56fe4C-F, H)\u3002AMX\u5bf9TNFA\u8868\u8fbe\u7684\u660e\u663e\u6291\u5236\u4ec5\u5728TDP43 Q331K\u7a81\u53d8\u4f53\u4e2d\u53ef\u89c1\uff08\u56fe4G)\u3002<\/span>    <\/span><\/o:page><\/section>\n
\"BMC<\/span><\/section>\n
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<\/o:p><\/span><\/section>\n
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\u8fd9\u7bc7\u6587\u7ae0\u7ed3\u5408<\/span>MR\u5206\u6790<\/span>\u548c<\/span>\u836f\u7269\u518d\u5229\u7528\u7b56\u7565<\/span>\uff0c\u5de7\u5999\u5730\u5c06\u9057\u4f20\u5b66\u8bc1\u636e\u8f6c\u5316\u4e3a\u6f5c\u5728\u7684ALS\u6cbb\u7597\u9776\u70b9\uff0c\u5c55\u73b0\u4e86\u4e00\u79cd\u521b\u65b0\u4e14\u9ad8\u6548\u7684\u836f\u7269\u53d1\u73b0\u9014\u5f84\u3002<\/span>\u8fd9\u6837\u5de7\u5999\u7684\u7814\u7a76\u8bbe\u8ba1\u786e\u5b9e\u8ba9\u4eba\u7fa1\u6155\uff0c\u7fa1\u6155\u7684\u540c\u65f6\u6709\u6ca1\u6709\u6fc0\u53d1\u8d77\u4f60\u7684\u52a8\u529b\u5462\uff1f<\/span><\/span>\u5927\u5bb6\u90fd\u5728\u8fdb\u6b65\uff0c\u4f60\u53ef\u4e0d\u80fd\u843d\u540e\u54e6\uff0c\u73b0\u5728\u626b\u7801\u6dfb\u52a0\u5c0f\u4e91\u5fae\u4fe1\uff0c\u5feb\u5feb\u52aa\u529b\uff0c\u5728\u5c0f\u4e91\u7684\u652f\u63f4\u4e0b\uff0c\u53d1\u8868\u4f60\u7684\u9ad8\u5206\u8bba\u6587\u5427\uff01<\/span><\/section>\n
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\u4ee3\u7801\u5408\u96c6<\/strong><\/span><\/a>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u57f9\u8bad\u73ed\u7cfb\u5217<\/span><\/strong>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u539f\u6587\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff08\u4e91\u751f\u4fe1\u5b66\u751f\u7269\u4fe1\u606f\u5b66\uff09\uff1aBMC Med.|\u592a\u79c0\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u4e0e3\u4e07+\u4e2aeQTL\u6570\u636e\u78b0\u649e\u51fa\u600e\u6837\u7cbe\u5f69\u7684\u706b\u82b1\uff1f\u56db\u5ddd\u5927\u5b66\u534e\u897f\u533b\u9662\u9648\u6c38\u5e73\u56e2\u961fshow\u7ed9\u4f60\u770b\uff01<\/a><\/p><\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4eca\u5929\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u7684\u6587\u7ae0\u901a\u8fc7\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian randomization, MR\uff09\u5206\u6790\u7ed3\u5408\u8868\u8fbe\u91cf\u6027 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43813"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43813"}],"version-history":[{"count":2,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43813\/revisions"}],"predecessor-version":[{"id":45342,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/43813\/revisions\/45342"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43813"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43813"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}