{"id":43864,"date":"2024-06-03T01:19:00","date_gmt":"2024-06-02T17:19:00","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43864"},"modified":"2024-06-02T17:34:56","modified_gmt":"2024-06-02T09:34:56","slug":"72efc51e0a","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43864","title":{"rendered":"\u7ebf\u7c92\u4f53cGAS\u548c\u94c1\u6b7b\u4ea1\u5173\u7cfb\u5927\u63ed\u79d8\uff1f\u534e\u5357\u7406\u5de5\u8054\u624b\u4e2d\u79d1\u5927\u7684\u8fd9\u7bc744.1\u5206\u7684Cell Research\u771f\u7684\u5f88\u9002\u5408\u79d1\u7814\u4eba\u7ec6\u54c1\uff01"},"content":{"rendered":"
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\"\u7ebf\u7c92\u4f53cGAS\u548c\u94c1\u6b7b\u4ea1\u5173\u7cfb\u5927\u63ed\u79d8\uff1f\u534e\u5357\u7406\u5de5\u8054\u624b\u4e2d\u79d1\u5927\u7684\u8fd9\u7bc744.1\u5206\u7684Cell<\/section>\n
\u4e0d\u77e5\u9053\u4f60\u4eec\u7684\u57ce\u5e02\u73b0\u5728\u591a\u5c11\u5ea6\u4e86\uff0c\u53cd\u6b63\u5de5\u4f4d\u4e0a\u7684\u5c0f\u4e91\u5df2\u7ecf\u6c57\u6d41\u6d43\u80cc\u4e86\uff0c\u6253\u5f00\u624b\u673a\u4e00\u770b\uff1a34\u2103\uff0c\u770b\u6765\u590f\u5929\u771f\u7684\u6765\u4e86~\u70c8\u65e5\u708e\u708e\uff0c\u8fd9\u65f6\u5982\u679c\u4f60\u770b\u5230\u4e30\u7855\u591a\u6c41\u7684\u897f\u74dc\uff0c\u53e3\u6c34\u80af\u5b9a\u4f1a\u76f4\u6d41\u4e09\u5343\u5c3a\u3002\u563f\uff01\u544a\u8bc9\u4f60\u4e00\u4e2a\u5c0f\u79d8\u5bc6\uff1a\u6211\u4e5f\u6700\u7231\u5403\u897f\u74dc\u4e86\uff01\u5f53\u7136\uff0c<\/span>\u6bcf\u65e5\u4e00\u66f4\u7684\u5c0f\u4e91\u4e5f\u4f1a\u6c38\u8fdc\u8ba9\u4f60\u5403\u4e0a\u70ed\u4e4e\u7684\u79d1\u7814\u74dc<\/span><\/strong>~\u4eca\u5929\u5e26\u5927\u5bb6\u4e00\u8d77\u63ed\u79d8\u7ebf\u7c92\u4f53cGAS\u4e0e\u94c1\u6b7b\u4ea1\u7684\u5173\u7cfb\uff0c\u987a\u4fbf\u770b\u770b\u6587\u7ae0\u662f\u5982\u4f55\u638c\u63e1\u6d41\u91cf\u5bc6\u7801\uff0c\u62ff\u4e0b44.1\u5206\u9876\u520a\uff01<\/span><\/section>\n
\u8fd9\u7bc7\u6587\u7ae0\u662f\u7531\u534e\u5357\u7406\u5de5\u5927\u5b66\/\u5e7f\u4e1c\u7701\u4eba\u6c11\u533b\u9662\u7684\u9ad8\u5e73\u3001\u949f\u79c0\u9896\u4ee5\u53ca\u4e2d\u56fd\u79d1\u5b66\u6280\u672f\u5927\u5b66\u7684\u5f20\u534e\u51e4\u56e2\u961f\u5408\u4f5c\u5728<\/span>\u300aCell Research\u300b<\/span>\u4e0a\u53d1\u8868\u7684\u9898\u4e3a\u201cMitochondria-localized cGAS suppresses ferroptosis to promote cancer progression\u201d\u7684\u7814\u7a76\u8bba\u6587\u3002\u8be5\u7814\u7a76\u901a\u8fc7<\/span>\u86cb\u767d\u8d28\u7ec4\u5b66\u5206\u6790<\/span><\/strong>\u548c\u4e00\u7cfb\u5217<\/span>HCC\u7ec6\u80de\u7684\u6572\u4f4e\u548c\u8fc7\u8868\u8fbe\u7cfb<\/span><\/strong>\u4ee5\u53ca<\/span>\u5f02\u79cd\u79fb\u690d\u5c0f\u9f20\u6a21\u578b<\/span><\/strong>\uff0c\u53d1\u73b0cGAS\u901a\u8fc7TOM70\u6613\u4f4d\u5230\u7ebf\u7c92\u4f53\uff0c\u4e0e\u5176\u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u8d28drp1\uff08\u4e0e\u7ebf\u7c92\u4f53\u5f62\u6001\u6709\u5173\u7684\u86cb\u767d1\uff09\u76f8\u4e92\u4f5c\u7528\u4ee5\u4fc3\u8fdb\u5176\u5be1\u805a\u5316\uff1b\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u5bfc\u81f4\u6291\u5236\u7ebf\u7c92\u4f53ROS\u79ef\u7d2f\u548cferroptosis\uff08\u94c1\u6b7b\u4ea1\uff09\u5728\u4f53\u5916\u548c\u4f53\u5185\u764c\u75c7\u7ec6\u80de\u4e2d\u7684\u53d1\u751f\u3002<\/span><\/section>\n
\u8fd9\u4e9b\u53d1\u73b0\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6846\u67b6\uff0c\u4ee5\u6307\u5bfc\u672a\u6765\u9488\u5bf9cGAS\u5728\u7ebf\u7c92\u4f53\u4e2d\u7684\u76f8\u4e92\u4f5c\u7528\u7684\u764c\u75c7\u6cbb\u7597\u7684\u53d1\u5c55<\/span>\u3002<\/span><\/span><\/strong>\u6574\u7bc7\u6587\u7ae0\u903b\u8f91\u7f1c\u5bc6\u3001\u601d\u8def\u4e25\u8c28\uff0c\u884c\u6587\u6d41\u7545\u4e1d\u6ed1\uff0c\u8fd9<\/span>\u4e0d\u5c31\u662f\u9ad8\u5206\u6d41\u91cf\u5bc6\u7801\u5417<\/span>\uff1f\u5b9d\u5b50\u4eec\uff0c\u6293\u7d27\u7801\u4f4f<\/span><\/span>\uff01<\/span>ps\uff1a\u60f3\u5b8c\u6210\u4ece\u770b\u6587\u7ae0\u5230\u53d1\u6587\u7ae0\u95ed\u73af\u7684\u5b9d\u5b50\uff0c\u5c0f\u4e91<\/span>\u6bcf\u65e5\u5728\u7ebf\uff0c\u52aa\u529b\u5ba3\u4f20\uff0c\u4f60\u8d1f\u8d23\u505a\u51b3\u5b9a\uff0c\u6211\u8d1f\u8d23\u4f60\u6ee1\u610f\uff01\u611f\u5174\u8da3\u7684\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5427\uff01<\/span><\/span>  <\/span><\/o:page><\/section>\n
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\"\u7ebf\u7c92\u4f53cGAS\u548c\u94c1\u6b7b\u4ea1\u5173\u7cfb\u5927\u63ed\u79d8\uff1f\u534e\u5357\u7406\u5de5\u8054\u624b\u4e2d\u79d1\u5927\u7684\u8fd9\u7bc744.1\u5206\u7684Cell<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\"\u7ebf\u7c92\u4f53cGAS\u548c\u94c1\u6b7b\u4ea1\u5173\u7cfb\u5927\u63ed\u79d8\uff1f\u534e\u5357\u7406\u5de5\u8054\u624b\u4e2d\u79d1\u5927\u7684\u8fd9\u7bc744.1\u5206\u7684Cell<\/span><\/section>\n
\u9898\u76ee\uff1a\u7ebf\u7c92\u4f53\u5b9a\u4f4d\u7684cGAS\u6291\u5236\u94c1\u6b7b\u4ea1\u4ee5\u4fc3\u8fdb\u764c\u75c7\u8fdb\u5c55<\/span><\/section>\n
\u6742\u5fd7\uff1aCell Res<\/span><\/section>\n
\u5f71\u54cd\u56e0\u5b50\uff1aIF=44.1<\/span><\/section>\n
\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e743\u6708<\/span><\/section>\n
\u7814\u7a76\u80cc\u666f<\/span><\/section>\n
\u73af\u72b6GMP-AMP\u5408\u6210\u9176\uff08cGAS\uff09\u662f\u5148\u5929\u514d\u75ab\u9632\u5fa1\u5bf9\u6297\u75c5\u6bd2\u75c5\u539f\u4f53\u7684\u5173\u952e\u7ec4\u6210\u90e8\u5206\uff0c\u5f53\u8bc6\u522b\u5e76\u7ed3\u5408\u5230\u7ec6\u80de\u8d28\u4e2d\u7684\u5fae\u751f\u7269DNA\u65f6\uff0c\u4f1a\u4ea7\u751f\u4fe1\u4f7f\u5206\u5b50GMP-AMP\uff08cGAMP\uff09\uff0c\u8fdb\u800c\u6fc0\u6d3b\u86cb\u767d\u9002\u914d\u5668\u5e72\u6270\u7d20\u57fa\u56e0\u523a\u6fc0\u56e0\u5b50\uff08STING\uff09\uff0c\u4ece\u800c\u89e6\u53d1\u5148\u5929\u514d\u75ab\u53cd\u5e94\u3002\u6709\u7814\u7a76\u8868\u660e\uff0ccGAS\u5728\u764c\u75c7\u8fdb\u5c55\u4e2d\u626e\u6f14\u7740\u5173\u952e\u89d2\u8272\uff0c<\/span>\u4f46\u662f\u5176\u5728\u4e0d\u540c\u764c\u75c7\u8fdb\u5c55\u4e2d\u786e\u5207\u7684\u529f\u80fd\u548c\u673a\u5236\u4ecd\u7136\u4e0d\u6e05\u695a<\/span><\/strong>\u3002cGAS\u5df2\u7ecf\u88ab\u8bc1\u660e\u80fd\u591f\u68c0\u6d4b\u5230\u4ece\u53d7\u635f\u7ebf\u7c92\u4f53\u4e2d\u6cc4\u6f0f\u5230\u7ec6\u80de\u8d28\u4e2d\u7684\u7ebf\u7c92\u4f53DNA\uff08mtDNA\uff09\uff0c\u7136\u800c\uff0c<\/span>cGAS\u4e0e\u764c\u7ec6\u80de\u4e2d\u7ebf\u7c92\u4f53\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u4ecd\u7136\u4e0d\u6e05\u695a\u3002<\/span><\/strong><\/section>\n
\u672c\u7814\u7a76\u63ed\u793a\u4e86cGAS\u5728\u7ebf\u7c92\u4f53\u4e2d\u7684\u4e00\u4e2a\u672a\u88ab\u5145\u5206\u8ba4\u8bc6\u7684\u4f5c\u7528\uff0c\u5e76\u5c55\u793a\u4e86cGAS\u5b9a\u4f4d\u4e8e\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u7ec6\u80de\u7684\u5916\u7ebf\u7c92\u4f53\u819c\uff08OMM\uff09\u4ee5\u4fc3\u8fdb\u764c\u75c7\u8fdb\u5c55\u3002<\/span><\/section>\n
\u7814\u7a76\u7ed3\u679c<\/span><\/section>\n
1.cGAS\u5b9a\u4f4d\u4e8e\u764c\u7ec6\u80de\u7684\u7ebf\u7c92\u4f53<\/span><\/span><\/section>\n
\u9996\u5148\u901a\u8fc7HCC\u7ebf\u7c92\u4f53<\/span>LC-MS\/MS<\/span>\u9274\u5b9a\u7ebf\u7c92\u4f53\u8f6c\u4f4d\u86cb\u767d\uff0c\u53d1\u73b0cGAS\u7684\u7ebf\u7c92\u4f53\u8f6c\u4f4d<\/span>\uff1b\u63a5\u7740\u901a\u8fc7\u764c\u7ec6\u80de\u7cfb\u7ec6\u80de\u6838\u3001\u7ec6\u80de\u8d28\u3001\u7ebf\u7c92\u4f53\u4e9a\u7ec6\u80de\u7ec4\u5206\u7684<\/span>western blot<\/span>\u4ee5\u53ca<\/span>\u514d\u75ab\u8367\u5149<\/span>\u8bc1\u660ecGAS\u4e3b\u8981\u5b9a\u4f4d\u5728\u764c\u7ec6\u80de\u7684\u7ebf\u7c92\u4f53\uff1b\u8fdb\u4e00\u6b65\u5bf9\u4e34\u5e8aHCC\u6837\u672c\u3001YAP-5SA\u8bf1\u5bfc\u7684HCC\u6a21\u578b\u7684\u7ec4\u7ec7\u8fdb\u884c<\/span>\u7ebf\u7c92\u4f53\u514d\u75ab\u8367\u5149<\/span>\u3001<\/span>\u514d\u75ab\u7ec4\u5316\u5206\u6790<\/span>\uff0c\u8bc1\u660ecGAS\u4e3b\u8981\u5206\u5e03\u5728\u7ebf\u7c92\u4f53\u4e2d\uff0c\u5e76\u4e14\u80bf\u7624\u4e2dcGAS\u8868\u8fbe\u4e0a\u8c03\uff1b\u6700\u540e\u786e\u5b9acGAS\u7684<\/span>\u4e9a\u7ebf\u7c92\u4f53\u5b9a\u4f4d<\/span>\uff0c\u7ed3\u679c\u8868\u660eTOM70\u53c2\u4e0ecGAS\u7684OMM\u8f6c\u4f4d\u3002<\/span><\/span><\/section>\n
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2.\u7ebf\u7c92\u4f53\u5b9a\u4f4d\u7684cGAS\u6291\u5236\u94c1\u6b7b\u4ea1<\/span><\/section>\n
\u9996\u5148<\/span>\u6784\u5efacGAS\u6572\u4f4eHCC\u7ec6\u80de<\/span>\uff0c\u53d1\u73b0\u7ec6\u80de\u751f\u957f\u663e\u8457\u6291\u5236\u3001\u6b7b\u4ea1\u663e\u8457\u589e\u52a0\uff1b\u63a5\u7740\u8fc7\u8868\u8fbeWT\/MTS\/\u0394MTS-cGAS\uff0c\u53d1\u73b0\u0394MTS-cGAS\u65e0\u6cd5\u5b8c\u5168\u6062\u590dcGAS\u6572\u4f4e\u7ec6\u80de\u7684\u751f\u957f\u3001\u6b7b\u4ea1\u3002\u4f7f\u7528<\/span>\u4e0d\u540c\u6b7b\u4ea1\u7684\u6291\u5236\u5242<\/span>\u53d1\u73b0\u53ea\u6709\u94c1\u6b7b\u4ea1\u6291\u5236\u5242\u51cf\u8f7bmt-cGAS\u7f3a\u5931\u8bf1\u5bfc\u7684\u6b7b\u4ea1\uff0c\u5e76\u4e14\u4e0eMTS-cGAS\u7684\u4f5c\u7528\u76f8\u4f3c\uff1bMTS-cGAS\u964d\u4f4e\u94c1\u6b7b\u4ea1\u8bf1\u5bfc\u5242\u5904\u7406\u7684\u7ec6\u80de\u4e2dcGAS\u6572\u4f4e\u8bf1\u5bfc\u7684\u8102\u8fc7\u6c27\u5316\u3001\u6b7b\u4ea1\u3002<\/span><\/span>\u56e0\u6b64\uff0cmt-cGAS\u6291\u5236\u94c1\u6b7b\u4ea1\u3002<\/span><\/strong><\/section>\n
\u63a5\u7740\u7814\u7a76mt-cGAS\u5bf9\u7ebf\u7c92\u4f53\u7684\u5f71\u54cd\uff0c<\/span>\u7535\u955c<\/span>\u8868\u660emt-cGAS\u81f3\u5c11\u90e8\u5206\u8d1f\u8d23\u7ef4\u6301\u7ebf\u7c92\u4f53\u8d28\u91cf<\/span>\uff1b<\/span>Mito-ROS\u6210\u50cf<\/span>\u8868\u660emt-cGAS\u901a\u8fc7\u6291\u5236mtROS\u79ef\u7d2f\u4ece\u800c\u6291\u5236\u8102\u8fc7\u6c27\u5316\u3001\u94c1\u6b7b\u4ea1\u3002<\/span><\/span><\/section>\n
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3.\u7ebf\u7c92\u4f53cGAS\u6291\u5236\u94c1\u6b7b\u4ea1\uff0c\u4e0eSTING\u6fc0\u6d3b\u65e0\u5173    <\/span><\/o:page><\/section>\n
\u9996\u5148<\/span>\u6784\u5efacGAS\u5931\u6d3b\u7a81\u53d8\u4f53<\/span>cGASE225A\/D227A\uff0c<\/span><\/span>\u53d1\u73b0\u4e0d\u5f71\u54cd\u7ebf\u7c92\u4f53\u5b9a\u4f4d\u3001\u8102\u8fc7\u6c27\u5316\u6291\u5236\u80fd\u529b\uff0ccGAS\u50ac\u5316\u6291\u5236\u5242\u6548\u679c\u76f8\u540c\uff1b<\/span>\u63a5\u7740<\/span>\u68c0\u6d4b<\/span><\/span><\/span>STING\u901a\u8def<\/span><\/strong>\u6d3b\u6027<\/span>\uff0c\u53d1\u73b0TBK1\u3001IRF3\u78f7\u9178\u5316\u3001\u9776\u57fa\u56e0mRNA\u65e0\u6cd5\u68c0\u6d4b\u5230\uff0c\u5e76\u4e14STING\u5728\u809d\u7ec6\u80de\u3001\u809d\u764c\u7ec6\u80de\u4e2d\u4f4e\u8868\u8fbe\uff1b\u8fdb\u4e00\u6b65<\/span>\u6572\u9664STING<\/span>\uff0c\u53d1\u73b0\u4e0d\u5f71\u54cdmt-cGAS\u5bf9\u8102\u8fc7\u6c27\u5316\u3001\u94c1\u6b7b\u4ea1\u7684\u6291\u5236\u3002<\/span><\/span><\/section>\n
\u56e0\u6b64\uff0cmt-cGAS\u4ee5\u72ec\u7acb\u4e8e\u5178\u578b\u7684cGAS-STING\u901a\u8def\u7684\u65b9\u5f0f\uff0c\u6291\u5236\u8102\u8fc7\u6c27\u5316\u3001\u94c1\u6b7b\u4ea1\u3002<\/span><\/strong><\/section>\n
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4.\u7ebf\u7c92\u4f53cGAS\u4e0eDRP1\u7ed3\u5408\u5e76\u4fc3\u8fdb\u5176\u5be1\u805a\u5316<\/span><\/section>\n
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