{"id":43917,"date":"2024-06-02T01:20:10","date_gmt":"2024-06-01T17:20:10","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43917"},"modified":"2024-06-02T17:30:16","modified_gmt":"2024-06-02T09:30:16","slug":"0771b42522","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=43917","title":{"rendered":"\u6295\u7a3f\u5230\u89c1\u520a\u4e0d\u5230\u4e24\u4e2a\u6708\uff1f\u5317\u79d1\u5927\u827e\u51ac\u6885\u56e2\u961f\u96f6\u5b9e\u9a8c5.6\u5206\uff1a\u5355\u7ec6\u80de\u6316\u6398\u5206\u6790+\u673a\u5668\u5b66\u4e60+\u516c\u5171\u6570\u636e\u5e93+\u836f\u7269\u53d1\u73b0\uff0c\u9876\u7ea7\u601d\u8def\u6765\u4e86\uff01"},"content":{"rendered":"
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(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6742\u5fd7\uff1aInt J Mol Sci<\/span><\/p>\n

\u5f71\u54cd\u56e0\u5b50\uff1aIF=5.6<\/span><\/p>\n

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\u6570\u636e\u6765\u6e90<\/span><\/strong><\/span><\/p>\n\n\n\n\n\n
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6\u4e2accRCC\u6837\u672c<\/span>        <\/span><\/o:page><\/p>\n<\/td>\n

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GEO<\/span><\/p>\n<\/td>\n

\n

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ChEMBL\u3001MCE<\/span><\/p>\n<\/td>\n

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1. scRNA-seq\u5206\u6790ccRCC\u4e2d\u7ec6\u80de\u7c7b\u578b\u805a\u7c7b<\/span><\/span><\/p>\n

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\"\u6295\u7a3f\u5230\u89c1\u520a\u4e0d\u5230\u4e24\u4e2a\u6708\uff1f\u5317\u79d1\u5927\u827e\u51ac\u6885\u56e2\u961f\u96f6\u5b9e\u9a8c5.6\u5206\uff1a\u5355\u7ec6\u80de\u6316\u6398\u5206\u6790+\u673a\u5668\u5b66\u4e60+\u516c\u5171\u6570\u636e\u5e93+\u836f\u7269\u53d1\u73b0\uff0c\u9876\u7ea7\u601d\u8def\u6765\u4e86\uff01\"<\/span><\/p>\n

\u56fe1 \u672c\u7814\u7a76\u4e2d\u4f7f\u7528\u7684\u65b9\u6cd5\u548c\u8fc7\u7a0b\u7684\u5de5\u4f5c\u6d41\u7a0b<\/span><\/p>\n

\u7ecf\u8fc7Seurat\uff08R\u5305\uff09\u5904\u7406\u540e\uff0c\u4ececcRCC\u60a3\u8005\u4e2d\u83b7\u5f97\u4e8631,625\u4e2a\u9ad8\u8d28\u91cf\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u70b9\u3002\u57fa\u4e8e\u6807\u8bb0\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\u53cd\u6620\uff0c\u8fd9\u4e9b\u7ec6\u80de\u88ab\u5206\u7c7b\u4e3a\u4e94\u5927\u4e9a\u578b\uff1accRCC\u80bf\u7624\u7ec6\u80de\u3001\u4e0eTME\u76f8\u5173\u7684\u7ec6\u80de\u3001T\u7ec6\u80de\u3001\u5185\u76ae\u7ec6\u80de\uff08EC\uff09\u3001\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAF\uff09\u548c\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAM\uff09\u3002\u5728\u63a2\u7d22ccRCC\u4e2dTME\u65f6\uff0c\u53d1\u73b0\u6076\u6027\u7ec6\u80de\u4e0e\u514d\u75ab\u548c\u975e\u514d\u75ab\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\uff0c\u5f62\u6210\u8fd9\u4e00\u590d\u6742\u7684\u751f\u6001\u7cfb\u7edf\uff08\u56fe2\uff09\u3002\u4f5c\u8005\u968f\u540e\u5c06\u8fd9\u4e9b\u7ec6\u80de\u5206\u79bb\u51fa\u6765\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/span>\u603b\u4e4b\uff0c\u4f5c\u8005\u901a\u8fc7\u9ad8\u8d28\u91cf\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\uff0c\u6df1\u5165\u5206\u6790\u4e86ccRCC\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u7ec6\u80de\u5f02\u8d28\u6027\u548c\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u3002<\/span>    <\/span><\/span><\/p>\n

<\/o:page><\/p>\n

\"\u6295\u7a3f\u5230\u89c1\u520a\u4e0d\u5230\u4e24\u4e2a\u6708\uff1f\u5317\u79d1\u5927\u827e\u51ac\u6885\u56e2\u961f\u96f6\u5b9e\u9a8c5.6\u5206\uff1a\u5355\u7ec6\u80de\u6316\u6398\u5206\u6790+\u673a\u5668\u5b66\u4e60+\u516c\u5171\u6570\u636e\u5e93+\u836f\u7269\u53d1\u73b0\uff0c\u9876\u7ea7\u601d\u8def\u6765\u4e86\uff01\"<\/span><\/p>\n

\u56fe2 \u7ec6\u80de\u805a\u7c7b\u5206\u5e03\u548c\u4e0d\u540c\u7ec6\u80de\u4e9a\u7fa4\u7684\u6807\u8bb0\u57fa\u56e0\u70ed\u56fe<\/span><\/p>\n

2. \u5728\u5de8\u566c\u7ec6\u80de\u4e2d\u53d1\u73b0\u7684\u56db\u79cd\u4e9a\u7fa4<\/span><\/p>\n

\u5de8\u566c\u7ec6\u80de\u662f\u5148\u5929\u514d\u75ab\u7684\u5173\u952e\u7ec4\u6210\u90e8\u5206\uff0c\u80fd\u5e94\u5bf9\u75c5\u539f\u4f53\u5e76\u901a\u8fc7\u6297\u539f\u5448\u9012\u53c2\u4e0e\u9002\u5e94\u6027\u514d\u75ab\u3002\u5728\u80bf\u7624\u53d1\u5c55\u4e2d\uff0c\u5b83\u4eec\u4ee5TAM\u7684\u5f62\u5f0f\u5b58\u5728\u3002\u672c\u7814\u7a76\u53d1\u73b0\u4e86\u4e24\u79cdTAM\u4e9a\u578b\uff0c\u5e76\u901a\u8fc7Monocle2\u91cd\u5efa\u4e86\u5b83\u4eec\u7684\u7ec6\u80de\u5206\u5316\u6f14\u5316\u8f68\u8ff9\u3002\u7ed3\u679c\u8868\u660e\uff0cM1\u578bTAM\u5177\u6709\u6297\u80bf\u7624\u7279\u6027\uff0c\u800cM2\u578bTAM\u5219\u53ef\u80fd\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u548c\u514d\u75ab\u6291\u5236\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u8bc6\u522b\u4e86\u5f71\u54cdTAM\u5206\u5316\u7684\u5173\u952e\u57fa\u56e0ACTB\u3001CAPG\u548cSTXBP2\uff0c\u5e76\u8fdb\u4e00\u6b65\u5206\u6790\u4e86\u76f8\u5173\u57fa\u56e0\u7684\u8868\u8fbe\u6a21\u5f0f\uff08\u56fe3\uff09\u3002<\/span>\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u7406\u89e3TAM\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u89d2\u8272\u63d0\u4f9b\u4e86\u6df1\u5165\u89c1\u89e3\uff0c\u4e3a\u5f00\u53d1\u9488\u5bf9\u6027\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"\u6295\u7a3f\u5230\u89c1\u520a\u4e0d\u5230\u4e24\u4e2a\u6708\uff1f\u5317\u79d1\u5927\u827e\u51ac\u6885\u56e2\u961f\u96f6\u5b9e\u9a8c5.6\u5206\uff1a\u5355\u7ec6\u80de\u6316\u6398\u5206\u6790+\u673a\u5668\u5b66\u4e60+\u516c\u5171\u6570\u636e\u5e93+\u836f\u7269\u53d1\u73b0\uff0c\u9876\u7ea7\u601d\u8def\u6765\u4e86\uff01\"<\/span><\/p>\n

\u56fe3 UMAP\u3001\u8fdb\u5316\u8f68\u8ff9\u3001\u8868\u8fbe\u6c34\u5e73\u548c\u968f\u65f6\u95f4\u53d8\u5316\u7684\u70ed\u56fe<\/span><\/p>\n

3. ccRCC\u4e2d\u5185\u76ae\u7ec6\u80de\u7684\u516d\u79cd\u4e9a\u578b<\/span><\/p>\n

\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684EC\u7fa4\u4f53\u88ab\u8bc1\u5b9e\u53ef\u4ee5\u901a\u8fc7\u8c03\u8282\u514d\u75ab\u7ec6\u80de\u7684\u8fc1\u79fb\u3001\u6fc0\u6d3b\u72b6\u6001\u548c\u529f\u80fd\u6765\u8c03\u63a7\u708e\u75c7\u3002ccRCC\u662f\u9ad8\u5ea6\u8840\u7ba1\u5316\u7684\u80bf\u7624\uff0c\u5177\u6709\u65e0\u5e8f\u7684\u8840\u7ba1\u7ed3\u6784\u3002\u672c\u7814\u7a76\u8bc6\u522b\u4e86\u4e94\u79cdEC\u4e9a\u578b\u548c\u4e00\u4e2apro-EC\u4e9a\u578b\uff0c\u91cd\u5efa\u4e86\u8fd9\u4e9b\u4e9a\u578b\u7684\u6f14\u5316\u8f68\u8ff9\u3002\u5728EC\u53d1\u5c55\u7684\u672b\u671f\uff0cRND1\u548cENPP2\u57fa\u56e0\u9ad8\u5ea6\u8868\u8fbe\uff0c\u53c2\u4e0e\u8840\u7ba1\u53d1\u5c55\u548c\u91cd\u5851\u3002\u7279\u522b\u662fpro-EC\u548cEC3\u5728EC\u5206\u5316\u7684\u65e9\u671f\u9636\u6bb5\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0cSPP1\u548cCCL5\u57fa\u56e0\u5728\u8c03\u63a7\u514d\u75ab\u3001\u7ec6\u80de\u751f\u5b58\u548c\u80bf\u7624\u8fdb\u5c55\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528\uff08\u56fe4\uff09\u3002<\/span>\u8fd9\u4e9b\u53d1\u73b0\u63ed\u793a\u4e86EC\u4e9a\u578b\u5728ccRCC\u8840\u7ba1\u73af\u5883\u5efa\u7acb\u548c\u75c5\u7406\u8fdb\u7a0b\u4e2d\u7684\u5173\u952e\u89d2\u8272\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"\u6295\u7a3f\u5230\u89c1\u520a\u4e0d\u5230\u4e24\u4e2a\u6708\uff1f\u5317\u79d1\u5927\u827e\u51ac\u6885\u56e2\u961f\u96f6\u5b9e\u9a8c5.6\u5206\uff1a\u5355\u7ec6\u80de\u6316\u6398\u5206\u6790+\u673a\u5668\u5b66\u4e60+\u516c\u5171\u6570\u636e\u5e93+\u836f\u7269\u53d1\u73b0\uff0c\u9876\u7ea7\u601d\u8def\u6765\u4e86\uff01\"<\/span><\/p>\n

\u56fe4 EC\u7684\u805a\u7c7b\u3001\u8fdb\u5316\u8f68\u8ff9\u548c\u663e\u8457\u8868\u8fbe\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\u5206\u5e03<\/span><\/p>\n

4. scRNA-seq\u63ed\u793a\u4e86ccRCC\u4e2d\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u591a\u6837\u6027<\/span><\/p>\n

CAF\u5e7f\u6cdb\u5b58\u5728\u4e8e\u80bf\u7624\u7ec6\u80de\u548c\u8d85\u8fc750%\u7684\u57fa\u8d28\u7ec6\u80de\u4e2d\uff0c\u662f\u4e00\u7c7b\u80fd\u5206\u6ccc\u591a\u79cd\u6d3b\u6027\u56e0\u5b50\u4ee5\u8c03\u8282\u80bf\u7624\u7684\u53d1\u751f\u3001\u53d1\u5c55\u548c\u8f6c\u79fb\u7684\u6fc0\u6d3b\u6210\u7ea4\u7ef4\u7ec6\u80de\u3002\u5728ccRCC\u4e2d\uff0c\u4f5c\u8005\u9274\u5b9a\u51fa\u56db\u79cdCAF\u4e9a\u578b\uff1a\u4e09\u4e2a\u4e0d\u540c\u7684CAF\u4e9a\u7fa4\u548c\u4e00\u4e2a\u6210\u7ea4\u7ef4\u7ec6\u80de\u7fa4\u3002\u8f68\u8ff9\u5206\u6790\u663e\u793a\uff0c\u6210\u7ea4\u7ef4\u7ec6\u80de\u5904\u4e8e\u53d1\u5c55\u7684\u65e9\u671f\u9636\u6bb5\uff0c\u800cCAF-3\u548cCAF-2\u7ec6\u80de\u5219\u5206\u5316\u4e3a\u5177\u6709\u4e0d\u540c\u8f6c\u5f55\u7279\u5f81\u7684\u4e24\u7ec4\u3002CAF-3\u4e9a\u7fa4\u9ad8\u5ea6\u8868\u8fbeLumican\uff08LUM\uff09\u548cCOL1A1\u57fa\u56e0\uff0c\u8fd9\u4e9b\u57fa\u56e0\u4e0e\u80f6\u539f\u86cb\u767d\u7ea4\u7ef4\u7ec4\u7ec7\u3001\u7ec6\u80de\u8fc1\u79fb\u548c\u7ec4\u7ec7\u4fee\u590d\u7b49\u8fc7\u7a0b\u76f8\u5173\uff0c\u800cCAF-2\u7ec6\u80de\u9ad8\u5ea6\u8868\u8fbe\u7684CCL5\u548cNKG7\u57fa\u56e0\u5219\u4e0e\u6162\u6027\u708e\u75c7\u73af\u5883\u548c\u514d\u75ab\u53cd\u5e94\u6709\u5173\uff08\u56fe5\uff09\u3002<\/span>\u8fd9\u4e9b\u7ed3\u679c\u63ed\u793a\u4e86\u4e0d\u540cCAF\u4e9a\u578b\u5728\u80bf\u7624\u8fdb\u5c55\u548c\u514d\u75ab\u8c03\u8282\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff0c\u4e3a\u80bf\u7624\u6cbb\u7597\u63d0\u4f9b\u4e86\u6f5c\u5728\u7684\u65b0\u9776\u70b9\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"\u6295\u7a3f\u5230\u89c1\u520a\u4e0d\u5230\u4e24\u4e2a\u6708\uff1f\u5317\u79d1\u5927\u827e\u51ac\u6885\u56e2\u961f\u96f6\u5b9e\u9a8c5.6\u5206\uff1a\u5355\u7ec6\u80de\u6316\u6398\u5206\u6790+\u673a\u5668\u5b66\u4e60+\u516c\u5171\u6570\u636e\u5e93+\u836f\u7269\u53d1\u73b0\uff0c\u9876\u7ea7\u601d\u8def\u6765\u4e86\uff01\"<\/span>    <\/span><\/o:page><\/p>\n

\"\u6295\u7a3f\u5230\u89c1\u520a\u4e0d\u5230\u4e24\u4e2a\u6708\uff1f\u5317\u79d1\u5927\u827e\u51ac\u6885\u56e2\u961f\u96f6\u5b9e\u9a8c5.6\u5206\uff1a\u5355\u7ec6\u80de\u6316\u6398\u5206\u6790+\u673a\u5668\u5b66\u4e60+\u516c\u5171\u6570\u636e\u5e93+\u836f\u7269\u53d1\u73b0\uff0c\u9876\u7ea7\u601d\u8def\u6765\u4e86\uff01\"<\/span><\/p>\n

\u56fe5\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e9a\u7c07\u7684\u5206\u6790<\/span><\/p>\n

5. ccRCC\u514d\u75ab\u5fae\u73af\u5883\u4e2dT\u7ec6\u80de\u7279\u6027\u7684\u591a\u6837\u6027<\/span><\/p>\n

T\u7ec6\u80de\u662f\u5177\u6709\u80bf\u7624\u6740\u4f24\u7279\u6027\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u5728\u7ec6\u80de\u4ecb\u5bfc\u7684\u4e3b\u52a8\u514d\u75ab\u548c\u4e00\u5b9a\u7a0b\u5ea6\u7684\u4f53\u6db2\u514d\u75ab\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0cccRCC\u7ec6\u80de\u7fa4\u4e2d\u7684T\u7ec6\u80de\u88ab\u8bc6\u522b\u4e3aCD8+ T\u7ec6\u80de1\u3001CD8+ T\u7ec6\u80de2\u3001CD8+ T\u7ec6\u80de3\u548cCD4+ T\u7ec6\u80de\u3002\u7136\u800c\uff0c\u5728\u516d\u4e2accRCC\u6837\u672c\u4e2d\uff0c\u9664\u4e86\u4e00\u4e2a\u6765\u81ea3\u671f\u80bf\u7624\u7684\u6837\u672c\u5916\uff0cT\u7ec6\u80de\u7684\u8868\u8fbe\u8fdc\u4f4e\u4e8e\u5176\u4ed6\u7ec6\u80de\u3002\u8c03\u8282\u6027T\u7ec6\u80de\u4f5c\u4e3aCD4+ T\u7ec6\u80de\u7684\u4e3b\u8981\u514d\u75ab\u6291\u5236\u4e9a\u7fa4\uff0c\u5728\u591a\u79cd\u5b9e\u4f53\u7624\u4e2d\u9ad8\u5ea6\u6d78\u6da6\uff0c\u4e0e\u8bb8\u591a\u7c7b\u578b\u80bf\u7624\u7684\u8f83\u5dee\u4e34\u5e8a\u7ed3\u679c\u5bc6\u5207\u76f8\u5173\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u8003\u8651\u4e86\u8c03\u8282\u6027T\u7ec6\u80de\u548cCD4+ T\u7ec6\u80de\u7684\u4e3b\u8981\u7279\u5f81\u57fa\u56e0\u4f5c\u4e3a\u4e0b\u4e00\u6b65\u9009\u62e9TF\u7684\u5019\u9009\u57fa\u56e0\uff08\u56fe6\uff09\u3002<\/span>\u603b\u4e4b\uff0c\u8fd9\u4e9b\u53d1\u73b0\u63ed\u793a\u4e86\u4e0d\u540cT\u7ec6\u80de\u4e9a\u578b\u5728\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u4e2d\u7684\u4f5c\u7528\u53ca\u5176\u5bf9\u4e34\u5e8a\u7ed3\u679c\u7684\u6f5c\u5728\u5f71\u54cd\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"\u6295\u7a3f\u5230\u89c1\u520a\u4e0d\u5230\u4e24\u4e2a\u6708\uff1f\u5317\u79d1\u5927\u827e\u51ac\u6885\u56e2\u961f\u96f6\u5b9e\u9a8c5.6\u5206\uff1a\u5355\u7ec6\u80de\u6316\u6398\u5206\u6790+\u673a\u5668\u5b66\u4e60+\u516c\u5171\u6570\u636e\u5e93+\u836f\u7269\u53d1\u73b0\uff0c\u9876\u7ea7\u601d\u8def\u6765\u4e86\uff01\"<\/span><\/p>\n

\"\u6295\u7a3f\u5230\u89c1\u520a\u4e0d\u5230\u4e24\u4e2a\u6708\uff1f\u5317\u79d1\u5927\u827e\u51ac\u6885\u56e2\u961f\u96f6\u5b9e\u9a8c5.6\u5206\uff1a\u5355\u7ec6\u80de\u6316\u6398\u5206\u6790+\u673a\u5668\u5b66\u4e60+\u516c\u5171\u6570\u636e\u5e93+\u836f\u7269\u53d1\u73b0\uff0c\u9876\u7ea7\u601d\u8def\u6765\u4e86\uff01\"<\/span>    <\/span><\/o:page><\/p>\n

\u56fe6T\u7ec6\u80de\u4e9a\u7c07\u7684\u5206\u6790\u4ee5\u53caTCGA\u6807\u8bb0\u57fa\u56e0\u8868\u8fbe\u548c\u751f\u5b58\u5206\u6790<\/span><\/p>\n

6. EPAS1\/HIF-2\u03b1\u4e0eccRCC\u9ad8\u5ea6\u76f8\u5173<\/span><\/p>\n

\u5185\u76aePAS\u7ed3\u6784\u57df\u86cb\u767d1\uff08EPAS1\uff09\uff0c\u4ea6\u79f0\u4e3a\u7f3a\u6c27\u8bf1\u5bfc\u8f6c\u5f55\u56e0\u5b502\uff08HIF-2\u03b1\uff09\uff0c\u662f\u4e00\u79cd\u57fa\u7840\u87ba\u65cb-\u73af-\u87ba\u65cb\/PAS\u7ed3\u6784\u57df\u8f6c\u5f55\u56e0\u5b50\uff0c\u5728\u9ad8\u5ea6\u8840\u7ba1\u5316\u7684\u5668\u5b98\u4e2d\u9ad8\u5ea6\u8868\u8fbe\u3002\u4f5c\u4e3a\u7ef4\u6301\u4f53\u5185\u7a33\u6001\u7684\u4e3b\u8981\u8c03\u63a7\u56e0\u5b50\uff0cHIF\u901a\u8fc7\u6fc0\u6d3b\u5305\u62ec\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\uff08EPO\uff09\u57fa\u56e0\u548c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u57fa\u56e0\u5728\u5185\u7684\u591a\u4e2a\u57fa\u56e0\u6765\u8c03\u8282\u5bf9\u7f3a\u6c27\u7684\u54cd\u5e94\u3002\u7279\u522b\u662f\u5728ccRCC\u4e2d\uff0cVHL\u57fa\u56e0\u7a81\u53d8\u5931\u6d3b\u662f\u6700\u65e9\u7684\u9057\u4f20\u4e8b\u4ef6\u4e4b\u4e00\uff0c\u800cHIF\u53ef\u4ee5\u88ab\u8fd9\u79cd\u80bf\u7624\u6291\u5236\u86cb\u767d\uff08VHL\uff09\u6cdb\u7d20\u5316\uff0c\u5bfc\u81f4HIF-1\u03b1\u548cHIF-2\u03b1\u7684\u7d2f\u79ef\uff0c\u5e76\u8c03\u63a7ccRCC\u7684\u53d1\u5c55\u548c\u708e\u75c7\u3002\u6b64\u5916\uff0c\u7814\u7a76\u53d1\u73b0HIF-2\u03b1\u5728M2\u578b\u5de8\u566c\u7ec6\u80de\u6781\u5316\u8fc7\u7a0b\u4e2d\u88abT\u8f85\u52a9\u7ec6\u80de2\u578b\uff08Th2\uff09\u7ec6\u80de\u56e0\u5b50\u8bf1\u5bfc\uff0c\u7f3a\u4e4fHIF-2\u03b1\u7684\u9aa8\u9ad3\u7cfb\u5c06\u5bfc\u81f4\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAM\uff09\u6d78\u6da6\u51cf\u5c11\u548c\u80bf\u7624\u8fdb\u5c55\u7f13\u89e3\u3002HIF-2\u03b1\u7684\u7f3a\u5931\u8fd8\u4f1a\u589e\u52a0\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u51cb\u4ea1\u5e76\u51cf\u5c11\u4e2d\u6027\u7c92\u7ec6\u80de\u708e\u75c7\u3002<\/span>\u603b\u4e4b\uff0cEPAS1\/HIF-2\u03b1\u4e0eccRCC\u7684\u53d1\u751f\u548c\u53d1\u5c55\u5bc6\u5207\u76f8\u5173\uff0c\u662f\u80be\u764c\u4e2d\u8868\u8fbe\u6700\u9ad8\u7684\u9884\u540e\u6807\u5fd7\u7269\u4e4b\u4e00\u3002<\/span>    <\/span><\/o:page><\/p>\n

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\u56fe7EPAS1\u7684\u901a\u8def\u548c\u86cb\u767d\u7684\u7ed3\u6784\u57df<\/span><\/p>\n

7. \u9274\u5b9a\u51fa5\u79cd\u9488\u5bf9TF EPAS1\u7684\u5316\u5408\u7269<\/span><\/p>\n

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\u6587\u7ae0\u5c0f\u7ed3<\/span><\/strong><\/span><\/p>\n

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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/span><\/strong><\/span><\/p>\n

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\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span>\n<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e34\u5e8a\u516c\u5171\u6570\u636e\u5206\u6790<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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