{"id":44024,"date":"2024-06-02T01:20:57","date_gmt":"2024-06-01T17:20:57","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=44024"},"modified":"2024-06-02T17:28:06","modified_gmt":"2024-06-02T09:28:06","slug":"3e76628b6b","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=44024","title":{"rendered":"\u8fd9\u4e2a\u65b0\u82b1\u6837\u771f\u662f\u5168\u7403\u9996\u6b21\u7814\u7a76\uff01\u897f\u4ea4\u6768\u94c1\u6797\u6559\u6388\u56e2\u961f\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u63a2\u7a76\u80a0\u9053\u83cc\u7fa4\u4e0e\u667a\u529b\u7684\u5173\u7cfb"},"content":{"rendered":"
\n

\"\u8fd9\u4e2a\u65b0\u82b1\u6837\u771f\u662f\u5168\u7403\u9996\u6b21\u7814\u7a76\uff01\u897f\u4ea4\u6768\u94c1\u6797\u6559\u6388\u56e2\u961f\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u63a2\u7a76\u80a0\u9053\u83cc\u7fa4\u4e0e\u667a\u529b\u7684\u5173\u7cfb\"<\/p>\n

\u00a0\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian Randomization, MR\uff09<\/span><\/span>\u662f\u76ee\u524d\u975e\u5e38\u706b\u7206\u7684\u4e00\u79cd\u5206\u6790\u65b9\u6cd5\uff0c\u60f3\u5fc5\u5404\u4f4d\u5c0f\u4f19\u4f34\u4eec\u90fd\u6709\u6240\u8033\u95fb\u3002MR\u5206\u6790\u7684\u4f18\u70b9\u662f\u5f97\u5230\u7684\u5173\u8054\u4e0d\u53d7\u56e0\u679c\u5012\u7f6e\u7684\u5f71\u54cd\uff0c\u4e5f\u4e0d\u53d7\u6df7\u6742\u56e0\u7d20\u7684\u5f71\u54cd\u3002<\/span><\/span>\uff08\u4e0d\u4ec5\u5982\u6b64\uff0c\u5b83\u5bf9\u4e8e\u4f1a\u6572\u4ee3\u7801\u7684\u4eba\u6765\u8bf4\uff0c\u8fd8\u662f\u76f8\u5f53\u5bb9\u6613\u505a\u7684\uff0c\u60f3\u5b66\u4e60\u7684\u5c0f\u4f19\u4f34\u5feb\u5173\u6ce8\u5c0f\u4e91\u5b66\u4e60\u5427\uff01\uff09<\/span>\u90a3\u4e48\u4eca\u5929\uff0c\u5c0f\u4e91<\/span>\u53d1\u73b0\u4e86\u4e00\u7bc7\u6765\u81ea\u897f\u5b89\u4ea4\u901a\u5927\u5b66\u6768\u94c1\u6797\u6559\u6388\u56e2\u961f\u768410\u52061\u533aTop\u6587\u7ae0\u3002<\/span><\/span>\u8fd9\u9879\u7814\u7a76\u62a5\u544a\u4e86\u7b2c\u4e00\u4e2a\u7814\u7a76\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u548c\u667a\u529b\u4e4b\u95f4\u6f5c\u5728\u56e0\u679c\u5173\u7cfb\u7684MR\u5206\u6790\u3002<\/span>\u4ed6\u4eec\u4ec5\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u4e24\u6b65\u5206\u6790\u80a0\u9053\u83cc\u7fa4\u3001\u8111\u5bb9\u91cf\u548c\u667a\u529b\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u7a76\u7adf\u662f\u4ec0\u4e48\u65b9\u6cd5\uff0c\u4ec0\u4e48\u601d\u8def\uff1f\uff01\u522b\u6025\uff0c\u5c0f\u4e91<\/span>\u5e26\u4f60\u63ed\u79d8\u8fd9\u7bc70\u5b9e\u9a8c\u597d\u6587\uff01<\/span><\/span><\/p>\n

\u9996\u5148\uff0c\u8be5<\/span>\u56e2\u961f\u53d1\u73b0\u4e86\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u7684\u52a8\u6001\u53d8\u5316\u4f1a\u5f71\u54cd\u667a\u529b\u3002\u4f46\u662f\uff0c\u8fd9\u4e9b\u5173\u7cfb\u662f\u5426\u6709\u56e0\u679c\u5173\u7cfb\u4ecd\u7136\u96be\u4ee5\u6349\u6478\u3002\u8be5\u56e2\u961f\u4f7f\u7528\u6765\u81ea\u6700\u5927\u7684\u80a0\u9053\u5fae\u751f\u7269\u7fa4(n = 18,340)\u548c\u667a\u529b(n = 269,867)<\/span><\/span>\u5168\u57fa\u56e0\u7ec4<\/span><\/strong>\u5173\u8054\u7814\u7a76\u7684\u9057\u4f20\u53d8\u5f02\u8fdb\u884c\u4e86<\/span>\u53cc\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316(MR)\u5206\u6790<\/span><\/strong>\u3002\u7136\u540e\uff0c\u91c7\u7528\u53cd\u65b9\u5dee\u52a0\u6743\u65b9\u6cd5\u8fdb\u884cMR\u5206\u6790\uff0c\u5e76\u8f85\u4ee5\u4e00\u7cfb\u5217\u654f\u611f\u6027\u5206\u6790\u6765\u9a8c\u8bc1\u7ed3\u679c\u7684\u7a33\u5065\u6027\u3002\u8003\u8651\u5230\u6700\u540e\uff0c\u8111\u5bb9\u91cf\u4e0e\u667a\u529b\u4e4b\u95f4\u7684\u5bc6\u5207\u5173\u7cfb\uff0c\u8be5\u7814\u7a76\u56e2\u961f\u91c7\u7528<\/span>\u4e24\u6b65MR<\/span><\/strong>\u6765\u8bc4\u4f30\u662f\u5426\u901a\u8fc7\u8c03\u8282\u8111\u5bb9\u91cf\u6765\u4ecb\u5bfc\u5df2\u8bc6\u522b\u7684\u6548\u5e94(n = 47,316)\u3002\u6700\u7ec8\u7684\u7ed3\u679c\u8868\u660e\uff0c<\/span>\u8349\u85fb\u6746\u83cc<\/span><\/strong>\u5c5e\u5bf9\u667a\u529b\u5b58\u5728\u98ce\u9669\u6548\u5e94(\u4f18\u52bf\u6bd4(OR)\uff0c\u6bcf\u6807\u51c6\u5dee\u589e\u52a0\u667a\u529b\u53d8\u53160.968\/95%\u7f6e\u4fe1\u533a\u95f4\u4e3a0.952 ~ 0.985;P = 1.88\u00d710-4<\/sup>)\u548c<\/span>Fusicatenibacter\u83cc\u5c5e\uff08\u77ed\u94fe\u8102\u80aa\u9178\u4ea7\u751f\u83cc\uff09<\/span><\/strong>\u5bf9\u667a\u529b\u7684\u4fdd\u62a4\u4f5c\u7528(OR, 1.053;95%\u7f6e\u4fe1\u533a\u95f4\u4e3a1.024 ~ 1.082;P = 3.03\u00d710-4<\/sup>)\u3002\u4e24\u6b65\u78c1\u5171\u632f\u5206\u6790\u8fdb\u4e00\u6b65\u8868\u660eFusicatenibacter\u83cc\u5c5e\u5bf9\u667a\u529b\u7684\u5f71\u54cd\u90e8\u5206\u662f\u901a\u8fc7\u8c03\u8282\u8111\u5bb9\u91cf\u4ecb\u5bfc\u7684\uff0c\u5176\u4ecb\u5bfc\u6bd4\u4f8b\u4e3a33.6%(95%\u7f6e\u4fe1\u533a\u95f4\u4e3a6.8% ~ 60.4%;P = 0.014)\u3002<\/span>\u5c0f\u4e91\u8ba4<\/span><\/strong>\u4e3a\u8fd9\u7bc7\u6587\u7ae0\u7684\u5de7\u601d\u5728\u4e8e\u5b83\u7684\u9009\u9898\u65b0\u9896\u7279\u522b\uff0c\u7528\u4e24\u4e2a\u201c\u770b\u4f3c\u65e0\u5173\u201d\u7684\u53d8\u91cf\u6765\u53d1\u6398\u5176\u4e2d\u7684\u8054\u7cfb\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u7814\u7a76\u4ec5\u91c7\u7528\u4e24\u6b65\u7eaf\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff0c\u9009\u53d6\u201c\u8111\u5bb9\u91cf\u201d\u4e3a\u4e2d\u4ecb\uff0c\u5c31\u6df1\u5ea6\u6316\u6398\u4e86\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u548c\u667a\u529b\u4e4b\u95f4\u56e0\u679c\u5173\u7cfb\uff0c\u6700\u5927\u5316\u7684\u5229\u7528\u4e86\u6211\u4eec\u7684MR\u5206\u6790\u3002<\/span><\/strong>\u5c0f\u4f19\u4f34\u4eec\u4e0d\u59a8\u501f\u9274\u5b83\u7684\u601d\u8def\u548c\u60f3\u6cd5\uff0c\u6362\u79cd\u75be\u75c5\u518d\u590d\u73b0\uff0c\u8f7b\u677e\u62ff\u634f\u9ad8\u5206\u751f\u4fe1\u6587\u7ae0\uff01\u5077\u5077\u544a\u8bc9\u5c0f\u4f19\u4f34\u4eec\uff0c\u5173\u6ce8\u5c0f\u4e91<\/strong>\u5e26\u4f60\u4e86\u89e3\u751f\u4fe1\u70ed\u70b9\uff0c\u8ba9\u4f60\u624d\u601d\u6cc9\u6d8c\uff01\u5feb\u6765\u5173\u6ce8\u5427\uff01<\/span>\u00a0 \u00a0<\/span>\u00a0 \u00a0 \u00a0<\/span>\u00a0<\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\"\u8fd9\u4e2a\u65b0\u82b1\u6837\u771f\u662f\u5168\u7403\u9996\u6b21\u7814\u7a76\uff01\u897f\u4ea4\u6768\u94c1\u6797\u6559\u6388\u56e2\u961f\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u63a2\u7a76\u80a0\u9053\u83cc\u7fa4\u4e0e\u667a\u529b\u7684\u5173\u7cfb\"<\/section>\n<\/section>\n<\/section>\n
\n
\n
\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u00a0<\/span><\/p>\n

\"\u8fd9\u4e2a\u65b0\u82b1\u6837\u771f\u662f\u5168\u7403\u9996\u6b21\u7814\u7a76\uff01\u897f\u4ea4\u6768\u94c1\u6797\u6559\u6388\u56e2\u961f\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u63a2\u7a76\u80a0\u9053\u83cc\u7fa4\u4e0e\u667a\u529b\u7684\u5173\u7cfb\"<\/span><\/p>\n

\u9898\u76ee\uff1a\u80a0\u9053\u83cc\u7fa4\u3001\u8111\u5bb9\u91cf\u548c\u667a\u529b\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb:\u4e24\u6b65\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790<\/span><\/span><\/section>\n
\u6742\u5fd7\uff1aBiological Psychiatry<\/span><\/span><\/section>\n
\u5f71\u54cd\u56e0\u5b50\uff1aIF=10.6<\/span><\/span><\/section>\n

\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e742\u6708<\/span><\/span><\/p>\n

\u7814\u7a76\u80cc\u666f<\/span><\/p>\n

\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u662f\u6b63\u5e38\u751f\u7406\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u5728\u5927\u8111\u53d1\u80b2\u548c\u529f\u80fd\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/span>\u5efa\u7acb\u56e0\u679c\u5173\u7cfb\u5e76\u4f18\u5148\u8003\u8651\u8d1f\u8d23\u4e2a\u4f53\u667a\u529b\u5dee\u5f02\u7684\u76ee\u6807\u662f\u5176\u4e2d\u4e4b\u4e00\u5fc3\u7406\u548c\u8111\u79d1\u5b66\u7684\u5173\u952e\u6311\u6218\u3002\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u662f\u4e00\u4e2a\u9ad8\u5ea6\u590d\u6742\u548c\u591a\u6837\u5316\u7684\u9690\u85cf\u738b\u56fd\uff0c\u5728\u80a0\u8111\u4ea4\u6d41\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/span><\/span>\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7684\u6539\u53d8\u4f1a\u5f71\u54cd\u795e\u7ecf\u53d1\u80b2\u548c\u8ba4\u77e5\u80fd\u529b\u3002<\/span>\u751f\u547d\u65e9\u671f\u6297\u751f\u7d20\u66b4\u9732\u4e0e\u968f\u540e\u8f83\u5dee\u7684\u795e\u7ecf\u8ba4\u77e5\u7ed3\u679c\u76f8\u5173\u3002\u636e\u62a5\u9053\uff0c\u76ca\u751f\u83cc\u6444\u5165\u53ef\u4ee5\u6539\u5584\u8001\u5e74\u4eba\u7684\u6301\u7eed\u6ce8\u610f\u529b\u548c\u5de5\u4f5c\u8bb0\u5fc6\uff0c\u800c\u65e9\u671f\u7684\u7814\u7a76\u62a5\u544a\u4e86\u76ca\u751f\u83cc\u6444\u5165\u53ef\u80fd\u4f1a\u5bfc\u81f4\u8ba4\u77e5\u969c\u788d\u3002\u5bf9\u4e8e\u7279\u5b9a\u7684\u5206\u7c7b\u7fa4\uff0c\u591a\u7ec4\u5b66\u6574\u5408\u5206\u6790\u663e\u793a\uff0c\u6c14\u5473<\/span><\/span>\u6746\u83cc\u3001\u4e01\u9178\u5355\u80de\u83cc\u3001\u6b64\u5916\uff0c\u6c14\u5473\u6746\u83cc\u7684\u4e30\u5ea6\u4e0e\u5927\u8111\u7ed3\u6784\u548c\u4f53\u79ef\u7684\u51e0\u4e2a\u91cd\u8981\u7279\u5f81\u6709\u5173\u3002\u6700\u8fd1\u591a\u57fa\u56e0\u7ec4\u5173\u8054\u5206\u6790\u53d1\u73b0\uff0c\u5177\u6709\u4ea7\u751f<\/span><\/span>\u77ed\u94fe\u8102\u80aa\u9178<\/span>(SCFAs)\u80fd\u529b\u7684\u7ec6\u83cc\uff0c\u5c3d\u7ba1\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u7ec4\u6210\u4e0e\u8ba4\u77e5\u80fd\u529b\u6709\u5173\uff0c\u4f46\u56e0\u679c\u5173\u7cfb\u4ecd\u7136\u5f88\u5c11\u3002<\/span><\/span><\/span>\u6700\u7ec8\u7684\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u56e2\u961f\u53d1\u73b0\u4e86\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7279\u5f81\u5bf9\u667a\u529b\u7684\u5f3a\u6709\u529b\u7684\u9057\u4f20\u8bc1\u636e\uff0cFusicatenibacter\u83cc\u5c5e\u5bf9\u667a\u529b\u7684\u4fdd\u62a4\u4f5c\u7528\u90e8\u5206\u662f\u901a\u8fc7\u8c03\u8282\u8111\u5bb9\u91cf\u6765\u4ecb\u5bfc\u7684\uff0c\u5e76\u5f3a\u8c03\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u662f\u6cbb\u7597\u548c\u9884\u9632\u8ba4\u77e5\u969c\u788d\u7684\u6f5c\u5728\u76ee\u6807\u3002\u00a0<\/span> \u00a0\u00a0<\/span>\u00a0 \u00a0 \u00a0 \u00a0\u00a0<\/span><\/span>\u00a0<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/span>\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n
\n

\u6570\u636e\u96c6\/\u961f\u5217<\/span><\/p>\n<\/td>\n

\n

\u6570\u636e\u5e93<\/span><\/p>\n<\/td>\n

\n

\u6570\u636e\u7c7b\u578b<\/span><\/p>\n<\/td>\n

\n

\u8be6\u7ec6\u4fe1\u606f<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u6210\u6570\u636e<\/span><\/p>\n<\/td>\n

\n

MiBioGen<\/span><\/p>\n<\/td>\n

\n

\u57fa\u56e0\u5408\u96c6<\/span><\/p>\n<\/td>\n

\n

18340\u4e2a\u4e2a\u4f53\u768416S rRNA\u57fa\u56e0\u6d4b\u5e8f\u548c\u9057\u4f20\u8c31<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u667a\u529b\u7684\u9057\u4f20<\/span>\u6570\u636e<\/span><\/span><\/p>\n<\/td>\n

\n

GWAS<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n

\n

269,867\u540d\u6b27\u6d32\u8840\u7edf\u7684\u4e2a\u4f53<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u86cb\u767d\u8d28\u5b9a\u91cf\u6027\u72b6<\/span>\u7684<\/span>\u57fa\u56e0<\/span>\u6570\u636e<\/span><\/span><\/p>\n<\/td>\n

\n

GWAS<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n

\n

35,559 \u540d\u51b0\u5c9b\u4eba\u6b63\u5e38\u8f6c\u5316\u6c34\u5e73\u6bcf\u79cd\u6d4b\u8bd5\u86cb\u767d\u7ec4\u7ec7\u7279\u5f02\u6027\u8868\u8fbeeQTL\u6570\u636e<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8111\u5bb9\u91cf\u76f8\u5173\u7684\u9057\u4f20\u7684\u57fa\u56e0\u6570\u636e<\/span><\/p>\n<\/td>\n

\n

GWAS<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n

\n

17062\u540d\u53c2\u4e0e\u8005\uff0c\u5305\u62ec11,373\u540d\u53c2\u4e0e\u8005\uff0c\u5934\u56f4\u5305\u62ec18,881\u540d\u53c2\u4e0e\u8005\uff0c\u603b\u6837\u672c\u91cf\u4e3a47,316\u540d<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u795e\u7ecf\u6210\u50cf\u8868\u578b\u7684\u6c47\u603b\u7edf\u8ba1\u6570\u636e<\/span><\/p>\n<\/td>\n

\n

Nat Genet. 55:1483-1493<\/span><\/p>\n<\/td>\n

\n

\u6587\u732e<\/span><\/p>\n<\/td>\n

\n

36,843\u4e2a\u4eba\u7684180\u4e2a\u533a\u57df\u8fdb\u884c\u6d4b\u91cf\uff0c\u4ea7\u751f2,347\u79cd\u795e\u7ecf\u5f71\u50cf\u5b66\u8868\u578b<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7814\u7a76\u601d\u8def<\/span><\/p>\n

\u9057\u4f20\u5de5\u5177\u9009\u62e9<\/span><\/p>\n

\u6240\u4f7f\u7528\u7684\u9057\u4f20\u5de5\u5177\u5fc5\u987b\u6ee1\u8db3\u4e09\u4e2a\u5047\u8bbe\uff1a(1)\u9057\u4f20\u53d8\u5f02\u5e94\u4e0e\u66b4\u9732\u5bc6\u5207\u76f8\u5173\uff0c(2)\u9057\u4f20\u53d8\u5f02\u4e0d\u5e94\u4e0e\u4efb\u4f55\u6f5c\u5728\u7684\u6df7\u6742\u56e0\u7d20\u76f8\u5173\uff0c(3)\u9057\u4f20\u53d8\u5f02\u4e0d\u5e94\u72ec\u7acb\u4e8e\u66b4\u9732\u800c\u5f71\u54cd\u7ed3\u679c\u3002\u8be5\u56e2\u961f\u9996\u5148\u5bf9\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7ec4\u6210\u4f7f\u7528\u4e86\u4e00\u4e2a\u5bbd\u677e\u7684P\u503c\u9608\u503c1\u00d710-5<\/sup>\uff0c\u56e0\u4e3a\u53d1\u73b0\u4f4e\u4e8e\u8be5\u9608\u503c\u7684SNP\u89e3\u91ca\u6700\u591a\u3002\u5176\u6b21\uff0c\u901a\u8fc7\u5bf9\u8986\u76d6\u5173\u8054\u4fe1\u53f7\u7684\u6bcf\u4e2a\u57fa\u56e0\u7ec4\u7a97\u53e3\u5e94\u7528FINEMAP\u8fdb\u884c\u7edf\u8ba1\u7cbe\u7ec6\u5b9a\u4f4d\uff0c\u8bc4\u4f30\u8fd9\u4e9b\u53d8\u5f02\u662f\u5426\u80fd\u591f\u6355\u83b7\u8be5\u533a\u57df\u5185\u7684\u9057\u4f20\u5173\u8054\u3002\u6700\u540e\uff0c\u4ed6\u4eec\u901a\u8fc7\u5c06\u03b2\u503c\u4e0e\u76f8\u540c\u7684\u7b49\u4f4d\u57fa\u56e0\u5bf9\u9f50\u6765\u534f\u8c03SNP\u5bf9\u66b4\u9732\u548c\u7ed3\u679c\u7684\u5f71\u54cd\u3002<\/span><\/p>\n

\u6d88\u9664\u6df7\u6742\u56e0\u7d20<\/span><\/p>\n

\u4e3a\u4e86\u907f\u514d\u6f5c\u5728\u7684\u6df7\u6dc6\uff0c\u8be5\u56e2\u961f\u5728\u6b27\u6d32\u53c2\u4e0e\u8005\u7684PhenoScanner\u6570\u636e\u5e93\u4e2d\u5220\u9664\u4e86\u4e0e\u4f3c\u662f\u800c\u975e\u7684\u6df7\u6742\u56e0\u7d20\u663e\u8457\u76f8\u5173\u7684SNP\u3002\u56db\u4e2a\u6f5c\u5728\u7684\u6df7\u6742\u56e0\u7d20\u88ab\u8003\u8651\u5728\u5185\uff0c\u5305\u62ec\u996e\u98df\u3001\u793e\u4f1a\u7ecf\u6d4e\u5730\u4f4d\u3001\u996e\u9152\u548c\u5438\u70df\u884c\u4e3a\u3002\u636e\u62a5\u9053\uff0c\u8fd9\u4e9b\u7279\u5f81\u4f1a\u5f71\u54cd\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u6210\u548c\u667a\u529b\u6216\u8ba4\u77e5\u80fd\u529b\u3002<\/span><\/p>\n

\u9057\u4f20\u4eea\u5668\u7684\u8d28\u91cf\u63a7\u5236<\/span><\/p>\n

\u4ed6\u4eec\u5229\u7528\u6392\u9664\u4e86\u5177\u6709\u4e2d\u95f4\u7b49\u4f4d\u57fa\u56e0\u9891\u7387(>0.42)\u7684SNP\uff0c\u8fd9\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6f5c\u5728\u7684\u94fe\u7ffb\u8f6c\u95ee\u9898\u3002\u4e3a\u4e86\u63d0\u9ad8\u5269\u4f59\u9057\u4f20\u5de5\u5177\u7684\u51c6\u786e\u6027\u548c\u7a33\u5065\u6027\uff0c\u5220\u9664\u4e86RadialMR\u68c0\u6d4b\u5230\u7684\u5f02\u5e38\u591a\u6548\u6027SNPs\u3002RadialMR\u5229\u7528\u5f02\u8d28\u6027\u68c0\u9a8c(\u4fee\u6b63Q\u7edf\u8ba1\u91cf)\u8bc6\u522b\u5f02\u5e38\u591a\u6548\u6027SNPs\uff0c\u6807\u79f0\u663e\u8457\u6027\u6c34\u5e73\u4e3a0.05\u3002\u8ba1\u7b97F\u7edf\u8ba1\u91cf\u6765\u4f30\u8ba1\u9057\u4f20\u4eea\u5668\u7684\u5f3a\u5ea6\uff0c\u53ea\u6709\u7edf\u8ba1\u91cf\u4e3aF\u7edf\u8ba1\u91cf>10\u7684SNP\u88ab\u7eb3\u5165MR\u5206\u6790\u3002\u5254\u9664\u6df7\u6742\u56e0\u7d20\u548c\u8d28\u91cf\u63a7\u5236\u540e\uff0c\u6240\u6709211\u4e2a\u5206\u7c7b\u7fa4\u81f3\u5c11\u67093\u4e2aSNP\uff0c\u5e76\u8fdb\u884cMR\u5206\u6790\u3002<\/span><\/p>\n

\u53cc\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316<\/span><\/p>\n

\u4e24\u4e2a\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff1a\u8fdb\u884c\u53cc\u5411\u56e0\u679c\u5173\u7cfb\u6765\u6d4b\u8bd5\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7ec4\u6210\u662f\u5426\u4f1a\u56e0\u679c\u5f71\u54cd\u667a\u529b\u4ee5\u53ca\u667a\u529b\u662f\u5426\u4f1a\u56e0\u679c\u5f71\u54cd\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7ec4\u6210\u3002\u5229\u7528\u57fa\u4e8e\u4e58\u6cd5\u968f\u673a\u6548\u5e94\u6a21\u578b\u7684\u9006\u65b9\u5dee\u52a0\u6743\uff08IVW\uff09\u65b9\u6cd5\u4f5c\u4e3a\u4e3b\u8981\u56e0\u679c\u63a8\u65ad\u3002<\/span> \u00a0 \u00a0<\/span><\/p>\n

\u654f\u611f\u6027\u5206\u6790<\/span><\/p>\n

\u8be5\u56e2\u961f\u8fdb\u884c\u4e86\u4e00\u7cfb\u5217\u654f\u611f\u6027\u5206\u6790\uff0c\u4ee5\u89e3\u51b3\u56e0\u679c\u4f30\u8ba1\u4e2d\u6f5c\u5728\u7684\u591a\u6548\u6027\u95ee\u9898\uff1a\u2460\u4f7f\u7528MR-Egger\u56de\u5f52\u6765\u8bc4\u4f30\u57fa\u4e8e\u5176\u622a\u8ddd\u9879\u7684\u6c34\u5e73\u591a\u6548\u6027\u7684\u5b58\u5728\uff1b\u2461\u5229\u7528MRPRESSO\u68c0\u6d4b\u591a\u6548\u6027\u7684\u5b58\u5728(P < 0.05)\u3002MR-PRESSO\u5c06\u6240\u6709\u53d8\u5f02\u7684\u89c2\u6d4b\u8ddd\u79bb\u4e0e\u65e0\u6c34\u5e73\u591a\u6548\u6027\u7684\u96f6\u5047\u8bbe\u4e0b\u7684\u671f\u671b\u8ddd\u79bb\u8fdb\u884c\u6bd4\u8f83\uff1b\u2462\u4f7f\u7528Cochran ‘s Q\u7edf\u8ba1\u91cf\u8bc4\u4f30\u5f02\u8d28\u6027\uff0c\u8fd9\u662f\u56fa\u5b9a\u6548\u5e94\u65b9\u5dee\u52a0\u6743\u5206\u6790\u4e2d\u4e0d\u540c\u9057\u4f20\u53d8\u5f02\u4ea7\u751f\u7684P\u503c\u5c0f\u4e8e0.05\u63d0\u793a\u5b58\u5728\u591a\u6548\u6027\u3002<\/span><\/p>\n

\u4e2d\u4ecb\u5206\u6790<\/span><\/p>\n

\u901a\u8fc7<\/span>\u4e24\u6b65MR\u5206\u6790<\/span>\u6765\u8bc4\u4f30\u6240\u9274\u5b9a\u7684\u7c7b\u7fa4\u5bf9\u667a\u529b\u7684\u5f71\u54cd\u662f\u5426\u901a\u8fc7\u8c03\u8282\u8111\u5bb9\u91cf\u6765\u4ecb\u5bfc\uff1a<\/span><\/span><\/p>\n

\u2460\u4f30\u8ba1\u4e86\u7279\u5b9a\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7ec4\u6210\u5bf9\u8111\u5bb9\u91cf\u7684\u56e0\u679c\u5f71\u54cd\uff1b<\/span><\/span><\/p>\n

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\u2462\u7528\u95f4\u63a5\u6548\u5e94\u9664\u4ee5\u603b\u6548\u5e94\u3002\u91c7\u7528delta\u6cd5\u5f97\u5230\u4e86\u95f4\u63a5\u6548\u5e94\u7684\u6807\u51c6\u8bef\u5dee\u6765\u786e\u5b9a\u5df2\u9274\u5b9a\u7c7b\u7fa4\u901a\u8fc7\u8c03\u8282\u8111\u5bb9\u91cf\u5bf9\u667a\u529b\u7684\u8d21\u732e\u6240\u5360\u7684\u6bd4\u4f8b\u3002<\/span><\/span><\/p>\n

\"\u8fd9\u4e2a\u65b0\u82b1\u6837\u771f\u662f\u5168\u7403\u9996\u6b21\u7814\u7a76\uff01\u897f\u4ea4\u6768\u94c1\u6797\u6559\u6388\u56e2\u961f\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u63a2\u7a76\u80a0\u9053\u83cc\u7fa4\u4e0e\u667a\u529b\u7684\u5173\u7cfb\"<\/span><\/p>\n

\u56fe1GWAS\u8868\u793a\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76<\/span><\/p>\n

\u4e3b\u8981\u7ed3\u679c<\/span><\/p>\n

\u80a0\u9053\u83cc\u7fa4\u7ec4\u6210\u5bf9\u667a\u529b\u7684\u56e0\u679c\u5f71\u54cd<\/span><\/p>\n

IVW\u5206\u6790\u663e\u793a\uff0c29\u4e2a\u5206\u7c7b\u7fa4\u4e0e\u667a\u529b\u7684\u56e0\u679c\u5173\u7cfb\u5728\u540d\u4e49\u4e0a\u663e\u8457\u6c34\u5e73(P < 0.05)(\u88681)\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4e24\u4e2a\u7279\u5b9a\u5206\u7c7b\u7fa4\uff0c\u5373Oxalobacter\u83cc\u5c5e\u548cFusicatenibacter\u83cc\u5c5e\u7684\u9057\u4f20\u503e\u5411\u5728FDR\u6821\u6b63\u540e\u8fbe\u5230\u4e86\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u8349\u85fb\u6746\u83cc\u5c5e\u4e30\u5ea6\u4e0e\u667a\u529b\u5448\u8d1f\u76f8\u5173(\u88682)\u3002MR RAPS\u7684\u4f30\u8ba1\u503c\u5728\u5927\u5c0f\u4e0a\u76f8\u4f3c\u3002\u8be5\u56e2\u961f\u8fd8\u53d1\u73b0\u4e86Fusicatenibacter\u83cc\u5c5e\u7684\u4e30\u5ea6\u4e0e\u667a\u529b\u5448\u6b63\u76f8\u5173\u7684\u56e0\u679c\u8bc1\u636e(\u88682)\u3002MR RAPS\u548c\u52a0\u6743\u4e2d\u4f4d\u6570\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u7ed3\u679c\u3002\u4e0e\u5176\u4ed6\u65b9\u6cd5\u76f8\u6bd4\uff0c\u52a0\u6743\u6a21\u5f0f\u548cMR Egger\u65b9\u6cd5\u7684CIs\u66f4\u5bbd\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u4e0eIVW\u76f8\u6bd4\uff0c\u5b83\u4eec\u7684\u7edf\u8ba1\u80fd\u529b\u66f4\u4f4e\u3002SNP\u5bf9\u8fd9\u4e24\u4e2a\u5206\u7c7b\u7fa4\u7684\u5f71\u54cd\u4e0e\u667a\u529b\u7684\u6563\u70b9\u56fe\u5982\u56fe2\u6240\u793a\uff0c\u5f69\u8272\u7ebf\u8868\u793a\u4e0d\u540cMR\u5206\u6790\u7684\u659c\u7387\u3002<\/span><\/p>\n

\"\u8fd9\u4e2a\u65b0\u82b1\u6837\u771f\u662f\u5168\u7403\u9996\u6b21\u7814\u7a76\uff01\u897f\u4ea4\u6768\u94c1\u6797\u6559\u6388\u56e2\u961f\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u63a2\u7a76\u80a0\u9053\u83cc\u7fa4\u4e0e\u667a\u529b\u7684\u5173\u7cfb\"<\/span><\/p>\n

\u88681 \u80a0\u9053\u83cc\u7fa4\u4e0e\u667a\u529b\u4e4b\u95f4\u7684MR\u7ed3\u679c\u663e\u8457(P < 0.05)<\/span><\/p>\n

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\"\u8fd9\u4e2a\u65b0\u82b1\u6837\u771f\u662f\u5168\u7403\u9996\u6b21\u7814\u7a76\uff01\u897f\u4ea4\u6768\u94c1\u6797\u6559\u6388\u56e2\u961f\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u63a2\u7a76\u80a0\u9053\u83cc\u7fa4\u4e0e\u667a\u529b\u7684\u5173\u7cfb\"<\/span><\/p>\n

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\"\u8fd9\u4e2a\u65b0\u82b1\u6837\u771f\u662f\u5168\u7403\u9996\u6b21\u7814\u7a76\uff01\u897f\u4ea4\u6768\u94c1\u6797\u6559\u6388\u56e2\u961f\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u63a2\u7a76\u80a0\u9053\u83cc\u7fa4\u4e0e\u667a\u529b\u7684\u5173\u7cfb\"<\/span><\/p>\n

\u88683\u53cc\u5411MR\u7ed3\u679c\u663e\u793a\u667a\u529b\u4e0e\u80a0\u9053\u83cc\u7fa4\u4e4b\u95f4\u7684\u5173\u7cfb<\/span><\/p>\n

\"\u8fd9\u4e2a\u65b0\u82b1\u6837\u771f\u662f\u5168\u7403\u9996\u6b21\u7814\u7a76\uff01\u897f\u4ea4\u6768\u94c1\u6797\u6559\u6388\u56e2\u961f\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u63a2\u7a76\u80a0\u9053\u83cc\u7fa4\u4e0e\u667a\u529b\u7684\u5173\u7cfb\"<\/span><\/p>\n

\u88684\u667a\u5546\u4e0e\u80a0\u9053\u83cc\u7fa4\u5173\u7cfb\u7684MR\u7ed3\u679c\u663e\u8457(P < 0.05)<\/span><\/p>\n

\u4e2d\u4ecb\u5206\u6790<\/span><\/p>\n

\u8fdb\u884c\u4e86\u4e24\u6b65MR\u5206\u6790\uff0c\u4ee5\u7814\u7a76\u6240\u9274\u5b9a\u7684\u7c7b\u7fa4\u5bf9\u667a\u529b\u7684\u5f71\u54cd\u662f\u5426\u901a\u8fc7\u8c03\u8282\u8111\u5bb9\u91cf\u6765\u4ecb\u5bfc\u3002\u6211\u4eec\u9996\u5148\u4f7f\u7528\u7279\u5b9a\u4e8e\u8349\u9178\u6746\u83cc\u548cFusicatenibacter\u83cc\u5c5e\u7684\u9057\u4f20\u4eea\u5668\u4f30\u8ba1\u4e86\u9274\u5b9a\u7684\u5206\u7c7b\u7fa4\u5bf9\u8111\u5bb9\u91cf\u7684\u56e0\u679c\u6548\u5e94\u3002\u4f7f\u7528\u4e0e\u8111\u5bb9\u91cf\u76f8\u5173\u7684\u9057\u4f20\u5de5\u5177\u8bc4\u4f30\u4e86\u8111\u5bb9\u91cf\u5bf9\u667a\u529b\u7684\u56e0\u679c\u5f71\u54cd\uff0c\u53d1\u73b0\u4e86\u8111\u5bb9\u91cf\u5bf9\u667a\u529b\u5f71\u54cd\u7684\u6781\u5176\u56e0\u679c\u7684\u8bc1\u636e\uff08\u56fe4\uff09\u3002\u7531\u4e8e\u8111\u5bb9\u91cf\u548c\u667a\u529b\u90fd\u5305\u62ec\u6765\u81eaUKB\u7684\u53d7\u8bd5\u8005\uff0c\u5e76\u4e14\u66b4\u9732\u91cf\u548c\u7ed3\u679cGWASs\u4e4b\u95f4\u7684\u6837\u672c\u91cd\u53e0\u53ef\u80fd\u4f1a\u4f7f\u4f30\u8ba1\u504f\u5411\u4e8e\u6df7\u6dc6\u4f30\u8ba1\u3002\u4ed6\u4eec\u4f7f\u7528Burgess\u53ca\u5176\u540c\u4e8b\u63cf\u8ff0\u7684\u65b9\u6cd5\u4f30\u8ba1\u4e86\u7531\u4e8e\u53c2\u4e0e\u8005\u91cd\u53e0\u9020\u6210\u7684\u504f\u5dee\u3002\u7ed3\u679c\u8868\u660e\uff0c\u53d1\u73b0\u6700\u59276.3%\u7684\u8111\u5bb9\u91cf\u53c2\u4e0e\u8005\u4e0e\u667a\u529bGWAS\u91cd\u53e0(17,062\/269,867)\uff0c\u5728MR\u7814\u7a76\u4e2d\u4f30\u8ba1\u504f\u5dee<0.82%\u3002\u8fd9\u8868\u660e\u6211\u4eec\u7684MR\u7ed3\u679c\u4e0d\u592a\u53ef\u80fd\u53d7\u5230\u8111\u5bb9\u91cf\u548c\u667a\u529b\u4e4b\u95f4\u6837\u672c\u91cd\u53e0\u7684\u5f71\u54cd\u3002<\/span>\u6700\u540e\uff0c\u6211\u4eec\u53d1\u73b0Fusicatenibacter\u83cc\u5c5e\u901a\u8fc7\u8c03\u8282\u8111\u5bb9\u91cf\u95f4\u63a5\u5f71\u54cd\u667a\u529b\uff08\u88685\uff09<\/span><\/span><\/p>\n

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\u88685\u53cc\u5411MR\u7ed3\u679c\u663e\u793a\u8111\u5bb9\u91cf\u548c\u667a\u529b\u4e4b\u95f4\u7684\u5173\u7cfb<\/span><\/p>\n

\u6587\u7ae0\u5c0f\u7ed3<\/span><\/p>\n

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\n
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\"\u8fd9\u4e2a\u65b0\u82b1\u6837\u771f\u662f\u5168\u7403\u9996\u6b21\u7814\u7a76\uff01\u897f\u4ea4\u6768\u94c1\u6797\u6559\u6388\u56e2\u961f\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u63a2\u7a76\u80a0\u9053\u83cc\u7fa4\u4e0e\u667a\u529b\u7684\u5173\u7cfb\"<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/span><\/strong><\/span><\/p>\n

\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70ed\u70b9\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5b5f\u5fb7\u5c14\u968f\u673a\u5316<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u4e34\u5e8a\u516c\u5171\u6570\u636e\u5206\u6790<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u5355\u7ec6\u80de\u6d4b\u5e8f<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u80bf\u7624\u514d\u75ab\u4e0e\u5fae\u73af\u5883<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u673a\u5668\u5b66\u4e60<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u5355\u57fa\u56e0\u5206\u6790<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u751f\u4fe1\u4e91\u670d\u52a1\u5668<\/strong><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ee3\u7801\u5408\u96c6<\/strong><\/span><\/a>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u57f9\u8bad\u73ed\u7cfb\u5217<\/strong>\uff08\u70b9\u51fb\u67e5\u770b\uff09<\/span><\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n

\u539f\u6587\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff08\u4e91\u751f\u4fe1\u5b66\u751f\u7269\u4fe1\u606f\u5b66\uff09\uff1a\u8fd9\u4e2a\u65b0\u82b1\u6837\u771f\u662f\u5168\u7403\u9996\u6b21\u7814\u7a76\uff01\u897f\u4ea4\u6768\u94c1\u6797\u6559\u6388\u56e2\u961f\uff0c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u63a2\u7a76\u80a0\u9053\u83cc\u7fa4\u4e0e\u667a\u529b\u7684\u5173\u7cfb<\/a><\/p><\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u00a0\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian Randomization, MR\uff09\u662f\u76ee\u524d\u975e\u5e38\u706b\u7206\u7684\u4e00\u79cd\u5206\u6790\u65b9\u6cd5\uff0c\u60f3\u5fc5\u5404\u4f4d […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/44024"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44024"}],"version-history":[{"count":2,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/44024\/revisions"}],"predecessor-version":[{"id":44107,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/44024\/revisions\/44107"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44024"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}