{"id":44051,"date":"2024-06-02T01:21:10","date_gmt":"2024-06-01T17:21:10","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=44051"},"modified":"2024-06-02T17:27:09","modified_gmt":"2024-06-02T09:27:09","slug":"863abda64c","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=44051","title":{"rendered":"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377"},"content":{"rendered":"
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<\/mp-common-profile><\/section>\n
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1. <\/span>\u591a\u6a21\u5f0fPCD\u57fa\u56e0\u96c6\u6210\u5206\u6790\uff1a<\/span>\u7814\u7a76\u901a\u8fc7\u6574\u540813\u79cd\u4e0d\u540c\u7684\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\uff08PCD\uff09\u6a21\u5f0f\uff0c\u5bf9\u80ba\u817a\u764c\uff08LUAD\uff09\u8fdb\u884c\u4e86\u5168\u9762\u7684\u57fa\u56e0\u8868\u8fbe\u5206\u6790\uff0c\u8fd9\u4e3a\u7406\u89e3LUAD\u4e2dPCD\u7684\u590d\u6742\u6027\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u3002<\/span><\/span><\/p>\n

2. <\/span>\u5355\u7ec6\u80de\u548c\u673a\u5668\u5b66\u4e60\u7684\u7ed3\u5408\uff1a<\/span>\u5355\u7ec6\u80de\u6570\u636e\u4e0e\u673a\u5668\u5b66\u4e60\u7684\u7ed3\u5408\u4f7f\u5f97\u7814\u7a76\u8005\u80fd\u591f\u66f4\u6df1\u5165\u5730\u7406\u89e3\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u53ca\u5b83\u4eec\u5982\u4f55\u5171\u540c\u5f71\u54cd\u80bf\u7624\u7684\u53d1\u5c55\u548c\u6cbb\u7597\u54cd\u5e94\u3002<\/span>    <\/span><\/o:page><\/p>\n

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\"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377\"<\/section>\n<\/section>\n<\/section>\n
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\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n

\u4e91\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n

(\u52a0\u5fae\u4fe1\u5907\u6ce899<\/span>\u9886\u53d6\u8bd5\u7528)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


\n<\/span><\/p>\n

\"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377\"<\/span><\/p>\n

\u9898\u76ee\uff1a\u673a\u5668\u5b66\u4e60\u63ed\u793a\u80ba\u817a\u764c\u9884\u540e\u548c\u6cbb\u7597\u4e2d\u7684\u591a\u79cd\u7ec6\u80de\u6b7b\u4ea1\u6a21\u5f0f<\/span><\/p>\n

\u6742\u5fd7\uff1aNPJ Precis Oncol<\/span><\/p>\n

\u5f71\u54cd\u56e0\u5b50\uff1aIF=7.9<\/span><\/p>\n

\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e742\u6708<\/span><\/p>\n

\u53cb\u60c5\u63d0\u793a\uff1a\u6587\u672b\u53ef\u83b7\u53d6\u6587\u732e\u7684DOI\u53f7\u54e6~\u6216\u8005\u5173\u6ce8\u547c\u5438\u574a\uff0c\u56de\u590d\u201c123\u201d\u76f4\u63a5\u540e\u53f0\u83b7\u53d6\u539f\u6587\uff01\u6587\u732e\u7f16\u53f7\uff1a20240528<\/span><\/p>\n

<\/mp-common-profile><\/section>\n

\u7814\u7a76\u80cc\u666f<\/span><\/strong><\/span><\/p>\n

\u80ba\u764c\u662f\u5168\u7403\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u5176\u4e2d\u80ba\u817a\u764c\uff08LUAD\uff09\u662f\u6700\u5e38\u89c1\u7684\u7ec4\u7ec7\u5b66\u7c7b\u578b\u3002\u5c3d\u7ba1\u8bca\u65ad\u6280\u672f\u548c\u6cbb\u7597\u65b9\u6cd5\u6709\u6240\u8fdb\u6b65\uff0c\u4f46LUAD\u60a3\u8005\u7684\u9884\u540e\u4ecd\u7136\u4e0d\u4f73\uff0c5\u5e74\u751f\u5b58\u7387\u4ec5\u4e3a10-20%\u3002LUAD\u7684\u9ad8\u5f02\u8d28\u6027\u548c\u836f\u7269\u6297\u836f\u6027\u7684\u53d1\u5c55\u5bfc\u81f4\u53ea\u6709\u5c11\u6570\u60a3\u8005\u5bf9\u9776\u5411\u6cbb\u7597\u548c\u514d\u75ab\u6cbb\u7597\u6709\u826f\u597d\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u80fd\u591f\u9884\u6d4bLUAD\u60a3\u8005\u9776\u5411\u548c\u514d\u75ab\u7597\u6cd5\u7597\u6548\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5e76\u63a2\u7d22\u5176\u6f5c\u5728\u673a\u5236\uff0c\u4e3a\u836f\u7269\u8bbe\u8ba1\u548c\u4e34\u5e8a\u51b3\u7b56\u63d0\u4f9b\u6f5c\u5728\u9776\u70b9\u548c\u7406\u8bba\u57fa\u7840\u3002<\/span>    <\/span><\/o:page><\/p>\n

\u6570\u636e\u6765\u6e90<\/span><\/strong><\/span><\/p>\n\n\n\n\n\n\n
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\u6570\u636e\u96c6\/\u961f\u5217<\/span><\/p>\n<\/td>\n

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\u6570\u636e\u5e93<\/span><\/p>\n<\/td>\n

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\u6570\u636e\u7c7b\u578b<\/span><\/p>\n<\/td>\n

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\u8be6\u7ec6\u4fe1\u606f<\/span><\/p>\n<\/td>\n<\/tr>\n

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GSE116959\u3001GSE31210\u3001GSE50081\u548cGSE72094<\/span><\/p>\n<\/td>\n

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GEO<\/span><\/p>\n<\/td>\n

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RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

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LUAD\u961f\u5217<\/span><\/p>\n<\/td>\n<\/tr>\n

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GSE126044\u548cGSE78220<\/span><\/p>\n<\/td>\n

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GEO<\/span><\/p>\n<\/td>\n

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RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

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\u514d\u75ab\u6cbb\u7597\u961f\u5217\u7684\u4e34\u5e8a\u75c5\u7406\u4fe1\u606f\u548c\u5168\u57fa\u56e0\u7ec4\u8868\u8fbe\u6570\u636e<\/span><\/p>\n<\/td>\n<\/tr>\n

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TCGA-LUAD<\/span><\/p>\n<\/td>\n

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TCGA<\/span><\/p>\n<\/td>\n

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RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n

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L<\/span>UAD\u6837\u672c\u76f8\u5e94\u7684\u4e34\u5e8a\u75c5\u7406\u4fe1\u606f<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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\u7814\u7a76\u601d\u8def<\/span><\/strong><\/span><\/p>\n

\u672c\u7814\u7a76\u901a\u8fc7\u6574\u540813\u79cd\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\uff08PCD\uff09\u6a21\u5f0f\u3001bulk RNA\u3001\u5355\u7ec6\u80deRNA\u8f6c\u5f55\u7ec4\u5b66\u6570\u636e\u548c\u6765\u81eaTCGA-LUAD\u53ca\u516d\u4e2aGEO\u6570\u636e\u96c6\u7684\u4e34\u5e8a\u75c5\u7406\u5b66\u7ec6\u8282\uff0c\u5f00\u53d1\u548c\u9a8c\u8bc1\u4e86\u9884\u6d4b\u6a21\u578b\u3002\u5229\u7528\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\uff0c\u7814\u7a76\u8005\u8bc6\u522b\u4e86\u4e0eLUAD\u4e2dPCD\u76f8\u5173\u7684\u5341\u4e2a\u5173\u952e\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\uff0c\u5e76\u636e\u6b64\u6784\u5efa\u4e86\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u6307\u6570\uff08PCDI\uff09\u6a21\u578b\u3002\u901a\u8fc7\u5c06PCDI\u4e0e\u4e34\u5e8a\u7279\u5f81\u7ed3\u5408\uff0c\u5f00\u53d1\u4e86\u591a\u4e2a\u9884\u540e\u5217\u7ebf\u56fe\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u89c2\u5bdf\u4e86PCDI\u4e0eLUAD\u4e2d\u7684\u514d\u75ab\u7279\u5f81\u4e4b\u95f4\u7684\u663e\u8457\u76f8\u5173\u6027\uff0c\u5e76\u63a2\u8ba8\u4e86\u9ad8PCDI\u8bc4\u5206\u60a3\u8005\u5bf9\u514d\u75ab\u6cbb\u7597\u548c\u6807\u51c6\u8f85\u52a9\u5316\u7597\u65b9\u6848\u7684\u53ef\u80fd\u6297\u6027\uff0c\u4ee5\u53ca\u4ed6\u4eec\u53ef\u80fd\u4ece\u5176\u4ed6FDA\u652f\u6301\u836f\u7269\u4e2d\u83b7\u76ca\u7684\u60c5\u51b5\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377\"<\/span><\/p>\n

\u4e3b\u8981\u7ed3\u679c<\/span><\/strong><\/span><\/p>\n

1. LUAD\u60a3\u8005\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u57fa\u56e0\u7684\u53d8\u5f02\u666f\u89c2<\/span><\/p>\n

\u5bf9TCGA-LUAD\u548c GSE116959\u8fdb\u884c<\/span>\u5dee\u5f02\u8868\u8fbe\u5206\u6790\u5e76\u4e0ePCD\u76f8\u5173\u57fa\u56e0\u53d6\u4ea4\u96c6\uff0c<\/span>\u83b7\u5f9752\u4e2a<\/span>\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684<\/span>DEGs<\/span>\uff08\u56fe1a\uff09\u3002<\/span>\u56fe1b\u663e\u793a\u4e86DEGs\u7684RNA\u6c34\u5e73\uff0c\u56fe1c\u63cf\u8ff0\u4e86DEGs\u7684\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u3002<\/span>GO\/KEGG\u5bcc\u96c6\u5206\u6790<\/span>\u663e\u793a\uff0c\u8fd952\u4e2a\u57fa\u56e0\u4e3b\u8981\u53c2\u4e0e\u5404\u79cd\u81f4\u764c\u76f8\u5173\u7684\u9014\u5f84\uff0c\u5982\u5185\u5728\u51cb\u4ea1\u4fe1\u53f7\u3001p53\u4fe1\u53f7\u548c\u764c\u75c7\u7684\u9014\u5f84\u7b49\uff08\u56fe1d\uff0ce\uff09\u3002\u6700\u540e\u57fa\u4e8eTCGA\u6570\u636e\u5bf9\u8fd952\u4e2a\u57fa\u56e0\u8fdb\u884c<\/span>\u7a81\u53d8\u666f\u89c2\u5206\u6790<\/span>\u5e76\u5bf9Top10\u7a81\u53d8\u57fa\u56e0\u8fdb\u884c\u5c55\u793a\uff0c\u5176\u4e2dCDKN2A\u548cTNC\u8868\u73b0\u51fa\u6700\u9ad8\u7684\u7a81\u53d8\u9891\u7387\uff08\u56fe1f,g\uff09\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377\"<\/span><\/p>\n

\u56fe1 LUAD\u60a3\u8005PCD-DEG\u7684\u53d8\u5316 <\/span><\/o:page><\/p>\n

2. \u673a\u5668\u5b66\u4e60\u6784\u5efaLUAD\u60a3\u8005\u7684\u9884\u540e\u57fa\u56e0\u7279\u5f81<\/span><\/p>\n

\u57fa\u4e8eTCGA-LUAD\u4f7f\u7528LOOCV\u6846\u67b6\u62df\u540870\u79cd\u7c7b\u578b\u7684\u9884\u6d4b\u6a21\u578b\u5e76\u8ba1\u7b97\u6bcf\u4e2a\u6a21\u578b\u7684C\u6307\u6570\uff0c\u9009\u62e9C\u6307\u6570\u6700\u9ad8\u7684\u4e24\u4e2a\u6a21\u578b\u7ec4\u5408\uff08<\/span>Lasso\u548cRSF+Lasso<\/span>\uff09\u7b5b\u9009\u57fa\u56e0\uff0c\u5f97\u5230Top35\u57fa\u56e0\uff08\u56fe2a\uff0cb\uff09\u3002\u5c06\u8fd935\u4e2a\u57fa\u56e0\u4e0eLasso\u56de\u5f52\u5206\u6790\u786e\u5b9a\u7684\u57fa\u56e0\u53d6\u4ea4\u96c6\u5f97\u523010\u4e2a\u57fa\u56e0\uff08\u56fe2c-e\uff09\u3002\u57fa\u4e8e\u8fd910\u4e2a\u57fa\u56e0\u6784\u5efa\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u6307\u6570\uff08programmed cell death index, PCDI\uff09\u3002\u4f9d\u636ePCDI\u516c\u5f0f\u8ba1\u7b97\u6bcf\u4f4d\u60a3\u8005\u7684PCDI\u5e76\u5c06\u60a3\u8005\u5206\u4e3a\u9ad8\u4f4e\u98ce\u9669\u7ec4\uff0c\u5206\u6790\u4e24\u7ec4\u7684\u751f\u5b58\u5dee\u5f02\uff0c<\/span>\u9ad8PCDI\u7684\u9884\u540e\u8f83\u5dee<\/span>\uff08\u56fe2f\uff09\u3002<\/span><\/span><\/p>\n

\"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377\"<\/span>    <\/span><\/o:page><\/p>\n

\u56fe2 \u673a\u5668\u5b66\u4e60\u6784\u5efaPCDI\u6a21\u578b<\/span><\/p>\n

3. \u5217\u7ebf\u56fe\u7684\u6784\u5efa\u4e0e\u8bc4\u4f30<\/span><\/p>\n

\u9996\u5148\u4f7f\u7528<\/span>\u5355\u53d8\u91cf\u548c\u591a\u53d8\u91cfCox\u56de\u5f52<\/span>\u5206\u6790\u8bc1\u660e<\/span>PCDI\u5177\u6709\u72ec\u7acb\u9884\u540e\u610f\u4e49\u3002\u57fa\u4e8e\u591a\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\u7684\u7ed3\u679c<\/span>\u6784\u5efa\u5217\u7ebf\u56fe\uff0c\u6821\u51c6\u66f2\u7ebf\u548cROC\u66f2\u7ebf<\/span>\u8868\u660e\u8be5\u6a21\u578b\u80fd\u591f\u51c6\u786e\u9884\u6d4b\u8fd9\u4e9b\u65f6\u95f4\u95f4\u9694\u5185\u7684\u751f\u5b58\u7387\uff1b<\/span>DCA\u66f2\u7ebf<\/span>\u8bc1\u5b9e\u5217\u7ebf\u56fe\u4f18\u4e8e\u7814\u7a76\u4e2d\u4f7f\u7528\u7684\u5176\u4ed6\u9884\u6d4b\u56e0\u5b50\u3002\u6b64\u5916\uff0cKM\u66f2\u7ebf\u663e\u793a\u9ad8\u98ce\u9669\u7ec4\u548c\u4f4e\u98ce\u9669\u7ec4\u4e4b\u95f4\u89c2\u5bdf\u5230<\/span>\u663e\u8457\u7684\u751f\u5b58\u5dee\u5f02<\/span>\uff08\u56fe3\uff09\u3002<\/span><\/span><\/p>\n

\"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377\"<\/span>    <\/span><\/o:page><\/p>\n

\"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377\"<\/span><\/p>\n

\u56fe3 \u5217\u7ebf\u56fe\u6784\u5efa\u4e0e\u8bc4\u4f30<\/span><\/p>\n

4. \u5355\u7ec6\u80de\u5206\u6790\u8868\u660ePCDI\u8bc4\u5206\u4e0eLUAD\u7684\u53d1\u5c55\u76f8\u5173<\/span><\/p>\n

\u5bf9scRNA\u6d4b\u5e8f\u6570\u636e\u8fdb\u884c<\/span>\u8d28\u63a7\u3001\u964d\u7ef4\u805a\u7c7b\u548c\u7ec6\u80de\u6ce8\u91ca<\/span>\u540e\u83b7\u5f9738\u4e2a\u805a\u7c7b\u548c8\u79cd\u7ec6\u80de\u7c7b\u578b\uff08\u56fe4a\uff09\uff0c\u6bcf\u4e2a\u7ec6\u80de\u7c7b\u578b\u7684\u6807\u8bb0\u57fa\u56e0\u5982\u56fe\u6240\u793a\uff08\u56fe4b\uff09\u3002\u5bf910\u4e2a\u6a21\u578b\u57fa\u56e0\u5728\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e2d\u7684\u5206\u5e03\u548c\u8868\u8fbe\u8fdb\u884c\u5206\u6790\uff08\u56fe4c\uff09\u3002\u4f7f\u7528<\/span>inferCNV\u7b97\u6cd5<\/span>\u68c0\u6d4b\u6bcf\u4e2a\u4e0a\u76ae\u7ec6\u80de\u4e2d\u7684\u62f7\u8d1d\u6570\u53d8\u5316\u5e76\u8ba1\u7b97\u6bcf\u4e2a\u805a\u7c7b\u7684CNV\u5f97\u5206\uff08\u56fe4d\uff0c4e\uff09\uff0c\u4f9d\u636e\u8bc4\u5206\u5c06\u4e0a\u76ae\u7ec6\u80de\u5206\u7ec4\uff0c\u7136\u540e\u4f7f\u7528<\/span>Monocle 2\u8fdb\u884c\u4f2a\u65f6\u95f4\u8f68\u8ff9\u5206\u6790<\/span>\u4e0d\u540c\u7ec4\u4e0a\u76ae\u7ec6\u80de\u7684\u6f5c\u5728\u8fdb\u5316\uff08\u56fe4f\uff09\u3002\u6700\u540e\u4f7f\u7528\u8ba1\u7b97\u6bcf\u4e2a\u7ec6\u80de\u7684PCDI\u8bc4\u5206\uff0c<\/span>\u53d1\u73b0PCDI\u8bc4\u5206\u4e0eCNV\u8bc4\u5206\u5448\u6b63\u76f8\u5173<\/span>\uff08\u56fe4g\uff0c4h\uff09\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377\"<\/span><\/p>\n

\u56fe4 \u57fa\u4e8ePCDI\u7279\u5f81\u7684\u80bf\u7624\u5fae\u73af\u5883\u89e3\u5256<\/span><\/p>\n

5. PCDI\u5728\u514d\u75ab\u6cbb\u7597\u4e2d\u7684\u9884\u6d4b\u4f5c\u7528<\/span><\/p>\n

\u57fa\u4e8eLUAD\u6570\u636e\u96c6\uff0c\u91c7\u7528<\/span>TIDE\u8bc4\u5206<\/span>\u8bc4\u4f30\u514d\u75ab\u6cbb\u7597\u548cPCDI\u7684\u5173\u7cfb\uff0c\u8868\u660e\u5b58\u5728\u663e\u8457\u7684\u6b63\u76f8\u5173\u6027\uff08\u56fe5a\uff0cb\uff09\uff0c\u8868\u660e<\/span>PCDI\u5347\u9ad8\u7684\u60a3\u8005\u53ef\u80fd\u4e0d\u4f1a\u4ece\u514d\u75ab\u7597\u6cd5\u4e2d\u53d7\u76ca<\/span>\u3002\u5229\u7528GSE126044\u548cGSE78220\u6570\u636e\u96c6\uff0c\u8fdb\u4e00\u6b65\u8bc4\u4f30PCDI\u9884\u6d4bLUAD\u60a3\u8005\u5bf9\u6297PD-L1\u6cbb\u7597\u53cd\u5e94\u7684\u80fd\u529b\u3002\u53d1\u73b0\u4e0e\u4f4ePCDI\u60a3\u8005\u76f8\u6bd4\uff0c\u9ad8PCDI\u7684\u60a3\u8005\u8868\u73b0\u51fa\u8f83\u5dee\u7684\u751f\u5b58\u7387\uff08\u56fe5c\uff0cf\uff09\u3002\u9ad8PCDI\u7ec4\u5bf9\u6297PD-L1\u6709\u53cd\u5e94\u7684\u60a3\u8005\u767e\u5206\u6bd4\u660e\u663e\u4f4e\u4e8e\u4f4ePCDI\u7ec4\uff08\u56fe5d\uff0cg\uff09\u3002\u975e\u5e94\u7b54\u8005\u6bd4\u5e94\u7b54\u8005\u8868\u73b0\u51fa\u66f4\u9ad8\u7684PCDI\uff08\u56fe5e\uff0ch\uff09\u3002<\/span>    <\/span><\/o:page><\/p>\n

\"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377\"<\/span><\/p>\n

\"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377\"<\/span>    <\/span><\/o:page><\/p>\n

\u56fe5 PCDI\u5728\u514d\u75ab\u6cbb\u7597\u4e2d\u7684\u9884\u6d4b\u4f5c\u7528<\/span><\/p>\n

6. \u4e34\u5e8a\u6837\u672c\u4e2d\u7279\u5f81\u57fa\u56e0\u7684\u4f53\u5916\u5b9e\u9a8c\u9a8c\u8bc1<\/span><\/p>\n

\u5229\u7528RT-qPCR\u5206\u6790\u9a8c\u8bc110\u4e2a\u6a21\u578b\u57fa\u56e0\u5728\u4e34\u5e8a\u6837\u672c\u4e2d\u7684\u8868\u8fbe\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u764c\u65c1\u6837\u672c\u76f8\u6bd4\uff0c<\/span>CHEK2\u3001CD79A\u3001RRM2\u3001GAPDH\u3001ITGB4\u3001KRT18\u548cTMPRSS4\u5728LUAD\u4e2d\u8fc7\u8868\u8fbe<\/span>\uff0c\u800cCHRNA5\u3001CTLA4\u548cMMP1\u7684\u8868\u8fbe\u6ca1\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff08\u56fe6a-j\uff09\u3002\u6b64\u5916\uff0c\u4f7f\u7528HPA\u6570\u636e\u5e93\u8fdb\u884c\u9a8c\u8bc1\uff0c\u53d1\u73b0CHEK2\u3001RRM2\u3001GAPDH\u3001ITGB4\u3001KRT18\u548cTMPRSS4\u5728LUAD\u6837\u672c\u7684\u67d3\u8272\u66f4\u6df1\uff08\u56fe6k\uff09\u3002<\/span><\/span><\/p>\n

\"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377\"<\/span>    <\/span><\/o:page><\/p>\n

\"\u5927\u529b\u51fa\u5947\u8ff9\uff0c\u96c6\u9f5013\u79cd\u7ec6\u80de\u6b7b\u4ea1\u65b9\u5f0f\u53d17.9\u5206\uff01\u590d\u65e6\u5927\u5b66\u56e2\u961f\u51ed\u501f\u5355\u7ec6\u80de\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7684\u53cc\u91cdbuff\uff0c\u6210\u529f\u6380\u8d77\u201c\u7ec6\u80de\u6b7b\u4ea1\u201d\u5185\u5377\"<\/span><\/p>\n

\u56fe6 \u4e34\u5e8a\u6837\u672c\u4e2d\u7279\u5f81\u57fa\u56e0\u7684\u4f53\u5916\u5b9e\u9a8c\u9a8c\u8bc1<\/span><\/p>\n

\u6587\u7ae0\u5c0f\u7ed3<\/span><\/strong><\/span><\/p>\n

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PMID: 38409471<\/span><\/section>\n

DOI: <\/span>10.1038\/s41698-024-00538-5 <\/span><\/span><\/p>\n

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