{"id":46751,"date":"2024-06-10T08:25:56","date_gmt":"2024-06-10T00:25:56","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=46751"},"modified":"2024-06-10T08:27:06","modified_gmt":"2024-06-10T00:27:06","slug":"%e3%80%8a%e5%9f%ba%e5%9b%a0%e5%ae%b6%e6%97%8f%e5%ba%8f%e5%88%97%e5%a4%9a%e6%a0%b7%e6%80%a7%e8%af%84%e4%bc%b0%e5%b7%a5%e5%85%b7%ef%bc%9adgfr-r-%e5%8c%85%e3%80%8b","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=46751","title":{"rendered":"\u300a\u57fa\u56e0\u5bb6\u65cf\u5e8f\u5217\u591a\u6837\u6027\u8bc4\u4f30\u5de5\u5177\uff1adgfr R \u5305\u300b"},"content":{"rendered":"\n

<\/h1>\n\n\n\n

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\u4e09\u3001\u79d1\u5b66\u95ee\u9898<\/strong><\/p>\n\n\n\n

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    \n
  1. \u5982\u4f55\u4f30\u8ba1\u57fa\u56e0\u5bb6\u65cf\u7684\u5e8f\u5217\u591a\u6837\u6027\uff1f<\/li>\n\n\n\n
  2. \u5982\u4f55\u53ef\u89c6\u5316\u57fa\u56e0\u5bb6\u65cf\u7684\u5e8f\u5217\u591a\u6837\u6027\uff1f<\/li>\n\n\n\n
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    \u56db\u3001\u521b\u65b0\u70b9<\/strong><\/p>\n\n\n\n

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      \n
    1. \u5f00\u53d1\u4e86\u4e00\u4e2a\u540d\u4e3a dgfr \u7684 R \u5305\uff0c\u53ef\u4ee5\u7528\u6765\u8bc4\u4f30\u57fa\u56e0\u5bb6\u65cf\u7684\u5e8f\u5217\u591a\u6837\u6027\u3002<\/li>\n\n\n\n
    2. \u8be5 R \u5305\u53ef\u4ee5\u751f\u6210\u57fa\u56e0\u5bb6\u65cf\u7684\u8ddd\u79bb\u77e9\u9635\u3001\u8fdb\u884c\u7ef4\u5ea6\u7f29\u51cf\u3001\u786e\u5b9a\u6700\u4f18\u805a\u7c7b\u6570\uff0c\u5e76\u5c06\u57fa\u56e0\u5206\u914d\u5230\u6bcf\u4e2a\u805a\u7c7b\u4e2d\u3002<\/li>\n\n\n\n
    3. \u8be5 R \u5305\u53ef\u4ee5\u53ef\u89c6\u5316\u57fa\u56e0\u5bb6\u65cf\u7684\u5e8f\u5217\u591a\u6837\u6027\u548c\u8868\u8fbe\u8c31\uff0c\u4ee5\u53ca\u5176\u4ed6\u6570\u636e\uff08\u5982\u57fa\u56e0\u8868\u8fbe\u6570\u636e\uff09\u3002<\/li>\n\n\n\n
    4. \u8be5 R \u5305\u53ef\u4ee5\u7528\u4e8e\u7814\u7a76\u57fa\u56e0\u5bb6\u65cf\u7684\u8fdb\u5316\u3001\u529f\u80fd\u548c\u7ed3\u6784\u3002<\/li>\n<\/ol>\n\n\n\n

      \u4e94\u3001\u6570\u636e\u548c\u4ee3\u7801<\/strong><\/p>\n\n\n\n

      \u8fd9\u7bc7\u8bba\u6587\u4f7f\u7528\u4e86\u4e00\u4e2a\u540d\u4e3a trans-sialidase \u7684\u57fa\u56e0\u5bb6\u65cf\u4f5c\u4e3a\u6848\u4f8b\u7814\u7a76\uff0c\u8be5\u57fa\u56e0\u5bb6\u65cf\u5728\u514b\u6c0f\u9525\u866b\uff08Trypanosoma cruzi\uff09\u7684\u8868\u9762\u8868\u8fbe\uff0c\u662f\u6070\u52a0\u65af\u75c5\uff08Chagas disease\uff09\u7684\u75c5\u539f\u4f53\u3002\u4f5c\u8005\u4f7f\u7528\u4e86\u6765\u81ea YC6 \u83cc\u682a\u7684 616 \u4e2a\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u7684\u5e8f\u5217\u4f5c\u4e3a\u8f93\u5165\u6570\u636e\uff0c\u5e76\u4f7f\u7528\u4e86 dgfr R \u5305\u8fdb\u884c\u5206\u6790\u3002<\/p>\n\n\n\n

      \u516d\u3001\u7ed3\u679c\u56fe<\/strong><\/p>\n\n\n\n

      \u8fd9\u7bc7\u8bba\u6587\u63d0\u4f9b\u4e86\u591a\u5f20\u7ed3\u679c\u56fe\uff0c\u5176\u4e2d\u4e00\u5f20\u91cd\u8981\u7684\u7ed3\u679c\u56fe\u662f\u57fa\u56e0\u5bb6\u65cf\u7684\u5e8f\u5217\u591a\u6837\u6027\u548c\u8868\u8fbe\u8c31\u7684\u53ef\u89c6\u5316\uff08\u56fe\u7247 1\uff1a\u57fa\u56e0\u5bb6\u65cf\u7684\u5e8f\u5217\u591a\u6837\u6027\u548c\u8868\u8fbe\u8c31\u7684\u53ef\u89c6\u5316<\/a>\uff09\u3002\u8be5\u56fe\u5c55\u793a\u4e86\u57fa\u56e0\u5bb6\u65cf\u7684\u5e8f\u5217\u591a\u6837\u6027\u548c\u8868\u8fbe\u8c31\u7684\u53ef\u89c6\u5316\uff0c\u53ef\u4ee5\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u66f4\u597d\u5730\u7406\u89e3\u57fa\u56e0\u5bb6\u65cf\u7684\u8fdb\u5316\u3001\u529f\u80fd\u548c\u7ed3\u6784\u3002<\/p>\n\n\n\n

      \u4e03\u3001\u6587\u7ae0\u89e3\u8bfb<\/strong><\/p>\n\n\n\n

        \n
      1. \u9898\u76ee<\/strong>\uff1adgfr: an R package to assess sequence diversity of gene families\uff08dgfr\uff1a\u4e00\u4e2a\u7528\u4e8e\u8bc4\u4f30\u57fa\u56e0\u5bb6\u65cf\u5e8f\u5217\u591a\u6837\u6027\u7684 R \u5305\uff09<\/li>\n\n\n\n
      2. \u53d1\u8868\u6742\u5fd7<\/strong>\uff1aBMC Bioinformatics<\/li>\n\n\n\n
      3. \u57fa\u91d1\u652f\u6301<\/strong>\uff1aThis work was supported by Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais (APQ-01822-18); Instituto Nacional de Ci\u00eancia e Tecnologia de Vacina \u2013 INCTV; Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (310531\/2023-3). J.L.R.C. is supported by an MRC New Investigator Research Grant (MR\/T016019\/1).<\/li>\n\n\n\n
      4. \u4f5c\u8005\u548c\u4f5c\u8005\u4e4b\u95f4\u7684\u5206\u5de5<\/strong>\uff1aMethodology, LVA, JLRC, DCB; Conceptualization, LVA, JLRC, DCB; Validation, LVA, JLRC; Supervision, DCB; Writing\u2014original draft, LVA, JLRC, DCB. All authors reviewed the manuscript. All authors read and approved the final manuscript.<\/li>\n\n\n\n
      5. \u7814\u7a76\u5185\u5bb9<\/strong>\uff1a\u672c\u6587\u4ecb\u7ecd\u4e86\u4e00\u4e2a\u540d\u4e3a dgfr \u7684 R \u5305\uff0c\u8be5\u5305\u53ef\u4ee5\u7528\u4e8e\u8bc4\u4f30\u57fa\u56e0\u5bb6\u65cf\u7684\u5e8f\u5217\u591a\u6837\u6027\u3002\u4f5c\u8005\u9996\u5148\u4ecb\u7ecd\u4e86\u57fa\u56e0\u5bb6\u65cf\u7684\u6982\u5ff5\u548c\u91cd\u8981\u6027\uff0c\u7136\u540e\u8be6\u7ec6\u63cf\u8ff0\u4e86 dgfr R \u5305\u7684\u529f\u80fd\u548c\u4f7f\u7528\u65b9\u6cd5\u3002\u6700\u540e\uff0c\u4f5c\u8005\u901a\u8fc7\u4e00\u4e2a\u6848\u4f8b\u7814\u7a76\uff0c\u5c55\u793a\u4e86 dgfr R \u5305\u5728\u8bc4\u4f30\u57fa\u56e0\u5bb6\u65cf\u5e8f\u5217\u591a\u6837\u6027\u65b9\u9762\u7684\u5e94\u7528\u3002<\/li>\n\n\n\n
      6. \u7814\u7a76\u7ed3\u679c<\/strong>\uff1a\u672c\u6587\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cdgfr R \u5305\u53ef\u4ee5\u6709\u6548\u5730\u8bc4\u4f30\u57fa\u56e0\u5bb6\u65cf\u7684\u5e8f\u5217\u591a\u6837\u6027\uff0c\u5e76\u63d0\u4f9b\u4e86\u591a\u79cd\u53ef\u89c6\u5316\u65b9\u6cd5\uff0c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u66f4\u597d\u5730\u7406\u89e3\u57fa\u56e0\u5bb6\u65cf\u7684\u8fdb\u5316\u3001\u529f\u80fd\u548c\u7ed3\u6784\u3002<\/li>\n\n\n\n
      7. \u7ed3\u8bba<\/strong>\uff1a\u672c\u6587\u7684\u7ed3\u8bba\u662f\uff0cdgfr R \u5305\u662f\u4e00\u4e2a\u975e\u5e38\u6709\u7528\u7684\u5de5\u5177\uff0c\u53ef\u4ee5\u7528\u4e8e\u8bc4\u4f30\u57fa\u56e0\u5bb6\u65cf\u7684\u5e8f\u5217\u591a\u6837\u6027\uff0c\u5e76\u4e3a\u57fa\u56e0\u5bb6\u65cf\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u548c\u65b9\u6cd5\u3002<\/li>\n<\/ol>\n\n\n\n

        \u516b\u3001\u603b\u7ed3<\/strong><\/p>\n\n\n\n

        \u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u7bc7\u8bba\u6587\u4ecb\u7ecd\u4e86\u4e00\u4e2a\u975e\u5e38\u6709\u7528\u7684 R \u5305\uff0c\u53ef\u4ee5\u7528\u4e8e\u8bc4\u4f30\u57fa\u56e0\u5bb6\u65cf\u7684\u5e8f\u5217\u591a\u6837\u6027\u3002\u8be5\u5305\u5177\u6709\u7b80\u5355\u6613\u7528\u3001\u529f\u80fd\u5f3a\u5927\u3001\u53ef\u89c6\u5316\u6548\u679c\u597d\u7b49\u4f18\u70b9\uff0c\u53ef\u4ee5\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u66f4\u597d\u5730\u7406\u89e3\u57fa\u56e0\u5bb6\u65cf\u7684\u8fdb\u5316\u3001\u529f\u80fd\u548c\u7ed3\u6784\u3002\u5982\u679c\u4f60\u5bf9\u57fa\u56e0\u5bb6\u65cf\u7684\u7814\u7a76\u611f\u5174\u8da3\uff0c\u90a3\u4e48\u8fd9\u4e2a R \u5305\u7edd\u5bf9\u503c\u5f97\u4e00\u8bd5\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"

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