<\/title><br \/>\n<meta charset=\"utf-8\"><br \/>\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,maximum-scale=1.0,user-scalable=0,viewport-fit=cover\"><\/p>\n<style>\n*{margin:0;padding:0}html{-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;line-height:1.6}img{z-index:999;position:relative;max-width:100%;margin:10px 0;}body{letter-spacing:.034em}h1,h2,h3,h4,h5,h6{font-weight:400;font-size:16px}a{color:#576b95;text-decoration:none;-webkit-tap-highlight-color:rgba(0,0,0,0)}td,th{word-wrap:break-word;padding:5px 10px;border:1px solid #DDD;}table{margin-bottom:10px;border-collapse:collapse;display:table;width:100%!important;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}.rich_media_area_primary{padding:20px 16px 12px;background-color:#fafafa}@media (max-width:375px){.rich_media_area_primary{padding:20px 60px 15px 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src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_0CuCiczxXATRA1NT7QsFibQGILBxvQ-56.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/zcicibWZessAx2cF5xxW6pBGPmgTUt8qTlL9RiabvDGL72zZRhzS10IN01ZYt0CuCiczxXATRA1NT7QsFibQGILBxvQ\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" style=\"font-size: 16px;text-align: center;\" data-recalc-dims=\"1\"><span style=\"font-family: \u5b8b\u4f53;font-size: 16px;text-indent: 2em;\"><\/span><\/p>\n<section style=\"white-space: normal;\">\n<section style=\"box-sizing: border-box;max-width: 100%;\">\n<section>\n<section style=\"box-sizing: border-box;max-width: 100%;\">\n<section>\n<section style=\"box-sizing: border-box;max-width: 100%;\">\n<section>\n<section style=\"box-sizing: border-box;\">\n<section powered-by=\"xiumi.us\" style=\"box-sizing: border-box;\">\n<section style=\"line-height: 1.8;box-sizing: border-box;\">\n<section powered-by=\"xiumi.us\" style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section powered-by=\"xiumi.us\" style=\"font-size: 16px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;font-size: 16px;\">\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4eca\u5929\u5c0f\u679c\u4e3a\u5927\u5bb6\u5206\u4eab\u4e00\u4e0b\u4e24\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u6d41\u7a0b\uff0c\u6574\u4e2a\u5206\u6790\u8fc7\u7a0b\u6bd4\u8f83\u7b80\u5355\uff0c\u8be5\u5206\u6790\u6700\u91cd\u8981\u7684\u662f\u66b4\u9732\u56e0\u7d20\u548c\u7ed3\u5c40\u53d8\u91cfGWAS\u6570\u636e\u7684\u67e5\u627e\uff0c\u4e00\u822c\u90fd\u901a\u8fc7\u4e24\u79cd\u65b9\u5f0f\u83b7\u5f97\uff0c\u516c\u5171\u6570\u636e\u5e93\u548c\u53d1\u8868\u7684\u76f8\u5173\u6587\u7ae0\u83b7\u53d6\uff0c\u63a5\u4e0b\u6765\u5c31\u4e3a\u5927\u5bb6\u7528\u793a\u4f8b\u6570\u636e\u505a\u4e0b\u6f14\u793a\uff0c\u4ee3\u7801\u5982\u4e0b\uff1a<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\" \/><\/p>\n<\/section>\n<section style=\"text-align: left;margin: 10px 0%;justify-content: flex-start;display: flex;flex-flow: row nowrap;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: 12%;align-self: flex-end;flex: 0 0 auto;box-sizing: border-box;\">\n<section style=\"margin-top: 3px;margin-bottom: 3px;text-align: center;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(253, 198, 32);background-color: rgb(253, 198, 32);width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 100%;margin-left: auto;margin-right: auto;font-size: 18px;color: rgb(0, 0, 0);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">01<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 88%;align-self: flex-end;flex: 0 0 auto;box-sizing: border-box;\">\n<section style=\"margin-right: 0%;margin-bottom: 5px;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;border-bottom: 1px dashed rgb(175, 175, 175);margin-bottom: 0.25em;padding-left: 5px;padding-right: 5px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u5b89\u88c5\u9700\u8981\u7684R\u5305<\/p>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 0.5em;height: 0.5em;border-radius: 50%;background-color: rgb(253, 198, 32);box-sizing: border-box;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"cpp\"><code><span class=\"code-snippet_outer\">install.packages(<span class=\"code-snippet__string\">\"devtools\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">devtools::install_github(<span class=\"code-snippet__string\">\"MRCIEU\/TwoSampleMR\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">Install.packages(\u201cggplot2\u201d)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: left;margin: 10px 0%;justify-content: flex-start;display: flex;flex-flow: row nowrap;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: 12%;align-self: flex-end;flex: 0 0 auto;box-sizing: border-box;\">\n<section style=\"margin-top: 3px;margin-bottom: 3px;text-align: center;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(253, 198, 32);background-color: rgb(253, 198, 32);width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 100%;margin-left: auto;margin-right: auto;font-size: 18px;color: rgb(0, 0, 0);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">02<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 88%;align-self: flex-end;flex: 0 0 auto;box-sizing: border-box;\">\n<section style=\"margin-right: 0%;margin-bottom: 5px;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;border-bottom: 1px dashed rgb(175, 175, 175);margin-bottom: 0.25em;padding-left: 5px;padding-right: 5px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u5bfc\u5165\u9700\u8981\u7684R\u5305<\/p>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 0.5em;height: 0.5em;border-radius: 50%;background-color: rgb(253, 198, 32);box-sizing: border-box;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">library(TwoSampleMR)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">library(ggplot2)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: left;margin: 10px 0%;justify-content: flex-start;display: flex;flex-flow: row nowrap;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: 12%;align-self: flex-end;flex: 0 0 auto;box-sizing: border-box;\">\n<section style=\"margin-top: 3px;margin-bottom: 3px;text-align: center;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(253, 198, 32);background-color: rgb(253, 198, 32);width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 100%;margin-left: auto;margin-right: auto;font-size: 18px;color: rgb(0, 0, 0);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">03<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 88%;align-self: flex-end;flex: 0 0 auto;box-sizing: border-box;\">\n<section style=\"margin-right: 0%;margin-bottom: 5px;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;border-bottom: 1px dashed rgb(175, 175, 175);margin-bottom: 0.25em;padding-left: 5px;padding-right: 5px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u5206\u6790\u8fc7\u7a0b<\/p>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 0.5em;height: 0.5em;border-radius: 50%;background-color: rgb(253, 198, 32);box-sizing: border-box;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">bmi_exp <- extract_instruments(<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> outcomes=ieu-a<span class=\"code-snippet__number\" style=\"box-sizing: border-box;\">-835<\/span>,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> clump=TRUE, r2=<span class=\"code-snippet__number\" style=\"box-sizing: border-box;\">0.01<\/span>,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\" style=\"box-sizing: border-box;\"> kb=<span class=\"code-snippet__number\" style=\"box-sizing: border-box;\">5000<\/span>,access_token = <span class=\"code-snippet__literal\" style=\"box-sizing: border-box;\">NULL<\/span><\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> )<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">##\u83b7\u53d6\u7ed3\u5c40\u53d8\u91cf\u6570\u636e<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">t2d_out <- extract_outcome_data(<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> snps=bmi_exp$SNP,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> outcomes=ieu-a<span class=\"code-snippet__number\" style=\"box-sizing: border-box;\">-26<\/span>,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> proxies = FALSE,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> maf_threshold = <span class=\"code-snippet__number\" style=\"box-sizing: border-box;\">0.01<\/span>,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\" style=\"box-sizing: border-box;\"> access_token = <span class=\"code-snippet__literal\" style=\"box-sizing: border-box;\">NULL<\/span><\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u5bf9\u6570\u636e\u8fdb\u884c\u9884\u5904\u7406<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">mydata <- harmonise_data(<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> exposure_dat=bmi_exp,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> outcome_dat=t2d_out,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\" style=\"box-sizing: border-box;\"> action= <span class=\"code-snippet__number\" style=\"box-sizing: border-box;\">2<\/span><\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> )<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#MR\u5206\u6790<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">res <- mr(mydata)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">write.table(res,file=<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"twosampleMR.txt\"<\/span>,sep=<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"t\"<\/span>,quote=F)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.09351851851851851\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_EPCRKvqO19N6U037poNtXHwMyGDC2w.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAy34u8tx4u4aB0BOvhfL2bPibbkD1nWD3Udz0InbbcVZpO75EPCRKvqO19N6U037poNtXHwMyGDC2w\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">##\u654f\u611f\u6027\u5206\u6790<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u5f02\u8d28\u6027\u68c0\u9a8c<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">het <- mr_heterogeneity(mydata)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">het<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">write.table(het,file=<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"het.txt\"<\/span>,col.names=T,row.names=F,sep=<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"t\"<\/span>,quote=F)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\" style=\"box-sizing: border-box;\"><span class=\"code-snippet__meta\" style=\"box-sizing: border-box;\">#mr(mydata,method_list=c(<span class=\"code-snippet__meta-string\" style=\"box-sizing: border-box;\">'mr_ivw_mre'<\/span>)) #\u4f7f\u7528\u968f\u673a\u6548\u5e94\u6a21\u578b<\/span><\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u591a\u6548\u6027\u68c0\u9a8c<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">pleio <- mr_pleiotropy_test(mydata)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">pleio<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">write.table(pleio,file=<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"pleio.txt\"<\/span>,col.names=T,row.names=F,sep=<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"t\"<\/span>,quote=F)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u9010\u4e2a\u5254\u9664\u68c0\u9a8c<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">single <- mr_leaveoneout(mydata)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\" style=\"box-sizing: border-box;\"><span class=\"code-snippet__meta\" style=\"box-sizing: border-box;\">#pdf(file=<span class=\"code-snippet__meta-string\" style=\"box-sizing: border-box;\">\"leaveoneout.pdf\"<\/span>)<\/span><\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">mr_leaveoneout_plot(single)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">ggsave(<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"leaveoneout.pdf\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.960431654676259\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_YpykquwR7xGq48dgOwUHZzGZxEZIOg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAy34u8tx4u4aB0BOvhfL2bPnVsibIiaKTpnH6FaN5x8U5suuiaYpykquwR7xGq48dgOwUHZzGZxEZIOg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"556\" style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">##\u53ef\u89c6\u5316\u5206\u6790<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u7ed8\u5236\u6563\u70b9\u56fe<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">mr_scatter_plot(res,mydata)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">ggsave(<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"scatter_plot.pdf\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.92894280762565\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_ib7XHgMYW7V8jqTQpVyia6GU25icNg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAy34u8tx4u4aB0BOvhfL2bPkP59VjyoHaNSmJutoVxDbhrNvlvib7XHgMYW7V8jqTQpVyia6GU25icNg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"577\" style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u7ed8\u5236\u68ee\u6797\u56fe<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">res_single <- mr_singlesnp(mydata)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">mr_forest_plot(res_single)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">ggsave(<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"forest_plot.pdf\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9178082191780822\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_9QvQibRbhibwbhibgfB1KpDc84eDYQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAy34u8tx4u4aB0BOvhfL2bP5icu7WOg8CBceXdxZcamoWpEGTU79QvQibRbhibwbhibgfB1KpDc84eDYQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"584\" style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u7ed8\u5236\u6f0f\u6597\u56fe<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">mr_funnel_plot(res_single)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">ggsave(<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"funnel_plot.pdf\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9612546125461254\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_fjvwhstG5XEOgdwP7fPjwFSGCADe6Q.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAy34u8tx4u4aB0BOvhfL2bP2A8jD85pCia5uJX1KCLibISBP8fjvwhstG5XEOgdwP7fPjwFSGCADe6Q\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"542\" style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5c0f\u679c\u4eca\u5929\u5bf9\u4e24\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u5206\u4eab\u5c31\u5230\u8fd9\u91cc\uff0c\u6709\u9700\u8981\u7684\u53ef\u4ee5\u501f\u9274\u5b66\u4e60\u5965\uff0c\u4e0d\u8981\u5fd8\u8bb0\u70b9\u8d5e\u5173\u6ce8\u5440\uff0c\u4e0b\u671f\u5728\u89c1\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\" \/><\/p>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"white-space: normal;\">\n<section style=\"box-sizing: border-box;max-width: 100%;\">\n<section>\n<section style=\"box-sizing: border-box;max-width: 100%;\">\n<section>\n<section style=\"box-sizing: border-box;max-width: 100%;\">\n<section>\n<section style=\"box-sizing: border-box;\">\n<section powered-by=\"xiumi.us\" style=\"box-sizing: border-box;\">\n<section style=\"line-height: 1.8;box-sizing: border-box;\">\n<section powered-by=\"xiumi.us\" style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section powered-by=\"xiumi.us\" style=\"font-size: 16px;box-sizing: border-box;\">\n<p style=\"text-align: center;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwNjE0MDY3MQ==&mid=2650750896&idx=2&sn=eedf639d72ed894b623b97cb453ec731&chksm=831a7820b46df136d60bbcd98da1545dc7cdc7d23013ee352ad58b8413bd8b74496a1cb24158&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.3333333333333333\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_iaiaHEzznKTOlyfKcqVQP42FDibo8w.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/zcicibWZessAy34u8tx4u4aB0BOvhfL2bPXcU0hlPVBlHyCV8KxucGNR7x7NeiaiaHEzznKTOlyfKcqVQP42FDibo8w\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"600\" data-recalc-dims=\"1\"><\/span><\/a><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.3524305555555556\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_QUHyYjibg2ia6lPiajicNvvpymIibw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAy34u8tx4u4aB0BOvhfL2bPgiaZcmc82ib7ljic0DontvyrWwHIbn3PQUHyYjibg2ia6lPiajicNvvpymIibw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"576\" data-recalc-dims=\"1\"><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 0px;\"><mp-common-profile class=\"js_uneditable custom_select_card mp_profile_iframe\" data-pluginname=\"mpprofile\" data-weui-theme=\"light\" data-id=\"Mzg3OTg3MjQyNg==\" data-headimg=\"http:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAwvyLLXlYq0SJu55voD1bnb7juHUdkAibE5woL3FrUvV4nmfhXjL5DgcNYqYFsyFCZrof6ibA2ibPmuw\/0?wx_fmt=png\" data-nickname=\"\u751f\u4fe1\u679c\" data-alias=\"shengxinguoer\" 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bottom;width: 88%;align-self: flex-end;flex: 0 0 auto;box-sizing: border-box;\">\n<section style=\"margin-right: 0%;margin-bottom: 5px;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;border-bottom: 1px dashed rgb(175, 175, 175);margin-bottom: 0.25em;padding-left: 5px;padding-right: 5px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u5b89\u88c5\u9700\u8981\u7684R\u5305<\/p>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 0.5em;height: 0.5em;border-radius: 50%;background-color: rgb(253, 198, 32);box-sizing: border-box;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"cpp\"><code><span class=\"code-snippet_outer\">install.packages(<span class=\"code-snippet__string\">\"devtools\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">devtools::install_github(<span class=\"code-snippet__string\">\"MRCIEU\/TwoSampleMR\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">Install.packages(\u201cggplot2\u201d)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: left;margin: 10px 0%;justify-content: flex-start;display: flex;flex-flow: row nowrap;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: 12%;align-self: flex-end;flex: 0 0 auto;box-sizing: border-box;\">\n<section style=\"margin-top: 3px;margin-bottom: 3px;text-align: center;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(253, 198, 32);background-color: rgb(253, 198, 32);width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 100%;margin-left: auto;margin-right: auto;font-size: 18px;color: rgb(0, 0, 0);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">02<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 88%;align-self: flex-end;flex: 0 0 auto;box-sizing: border-box;\">\n<section style=\"margin-right: 0%;margin-bottom: 5px;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;border-bottom: 1px dashed rgb(175, 175, 175);margin-bottom: 0.25em;padding-left: 5px;padding-right: 5px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u5bfc\u5165\u9700\u8981\u7684R\u5305<\/p>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 0.5em;height: 0.5em;border-radius: 50%;background-color: rgb(253, 198, 32);box-sizing: border-box;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">library(TwoSampleMR)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">library(ggplot2)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: left;margin: 10px 0%;justify-content: flex-start;display: flex;flex-flow: row nowrap;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: 12%;align-self: flex-end;flex: 0 0 auto;box-sizing: border-box;\">\n<section style=\"margin-top: 3px;margin-bottom: 3px;text-align: center;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(253, 198, 32);background-color: rgb(253, 198, 32);width: 1.8em;height: 1.8em;line-height: 1.8em;border-radius: 100%;margin-left: auto;margin-right: auto;font-size: 18px;color: rgb(0, 0, 0);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">03<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 88%;align-self: flex-end;flex: 0 0 auto;box-sizing: border-box;\">\n<section style=\"margin-right: 0%;margin-bottom: 5px;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: bottom;border-bottom: 1px dashed rgb(175, 175, 175);margin-bottom: 0.25em;padding-left: 5px;padding-right: 5px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u5206\u6790\u8fc7\u7a0b<\/p>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: 0.5em;height: 0.5em;border-radius: 50%;background-color: rgb(253, 198, 32);box-sizing: border-box;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">bmi_exp <- extract_instruments(<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> outcomes=ieu-a<span class=\"code-snippet__number\" style=\"box-sizing: border-box;\">-835<\/span>,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> clump=TRUE, r2=<span class=\"code-snippet__number\" style=\"box-sizing: border-box;\">0.01<\/span>,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\" style=\"box-sizing: border-box;\"> kb=<span class=\"code-snippet__number\" style=\"box-sizing: border-box;\">5000<\/span>,access_token = <span class=\"code-snippet__literal\" style=\"box-sizing: border-box;\">NULL<\/span><\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> )<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">##\u83b7\u53d6\u7ed3\u5c40\u53d8\u91cf\u6570\u636e<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">t2d_out <- extract_outcome_data(<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> snps=bmi_exp$SNP,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> outcomes=ieu-a<span class=\"code-snippet__number\" style=\"box-sizing: border-box;\">-26<\/span>,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> proxies = FALSE,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> maf_threshold = <span class=\"code-snippet__number\" style=\"box-sizing: border-box;\">0.01<\/span>,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\" style=\"box-sizing: border-box;\"> access_token = <span class=\"code-snippet__literal\" style=\"box-sizing: border-box;\">NULL<\/span><\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u5bf9\u6570\u636e\u8fdb\u884c\u9884\u5904\u7406<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">mydata <- harmonise_data(<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> exposure_dat=bmi_exp,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> outcome_dat=t2d_out,<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\" style=\"box-sizing: border-box;\"> action= <span class=\"code-snippet__number\" style=\"box-sizing: border-box;\">2<\/span><\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\"> )<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#MR\u5206\u6790<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">res <- mr(mydata)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">write.table(res,file=<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"twosampleMR.txt\"<\/span>,sep=<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"t\"<\/span>,quote=F)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.09351851851851851\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_EPCRKvqO19N6U037poNtXHwMyGDC2w.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAy34u8tx4u4aB0BOvhfL2bPibbkD1nWD3Udz0InbbcVZpO75EPCRKvqO19N6U037poNtXHwMyGDC2w\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">##\u654f\u611f\u6027\u5206\u6790<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u5f02\u8d28\u6027\u68c0\u9a8c<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">het <- mr_heterogeneity(mydata)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">het<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">write.table(het,file=<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"het.txt\"<\/span>,col.names=T,row.names=F,sep=<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"t\"<\/span>,quote=F)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\" style=\"box-sizing: border-box;\"><span class=\"code-snippet__meta\" style=\"box-sizing: border-box;\">#mr(mydata,method_list=c(<span class=\"code-snippet__meta-string\" style=\"box-sizing: border-box;\">'mr_ivw_mre'<\/span>)) #\u4f7f\u7528\u968f\u673a\u6548\u5e94\u6a21\u578b<\/span><\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u591a\u6548\u6027\u68c0\u9a8c<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">pleio <- mr_pleiotropy_test(mydata)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">pleio<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">write.table(pleio,file=<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"pleio.txt\"<\/span>,col.names=T,row.names=F,sep=<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"t\"<\/span>,quote=F)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u9010\u4e2a\u5254\u9664\u68c0\u9a8c<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">single <- mr_leaveoneout(mydata)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\" style=\"box-sizing: border-box;\"><span class=\"code-snippet__meta\" style=\"box-sizing: border-box;\">#pdf(file=<span class=\"code-snippet__meta-string\" style=\"box-sizing: border-box;\">\"leaveoneout.pdf\"<\/span>)<\/span><\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">mr_leaveoneout_plot(single)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">ggsave(<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"leaveoneout.pdf\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.960431654676259\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_YpykquwR7xGq48dgOwUHZzGZxEZIOg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAy34u8tx4u4aB0BOvhfL2bPnVsibIiaKTpnH6FaN5x8U5suuiaYpykquwR7xGq48dgOwUHZzGZxEZIOg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"556\" style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">##\u53ef\u89c6\u5316\u5206\u6790<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u7ed8\u5236\u6563\u70b9\u56fe<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">mr_scatter_plot(res,mydata)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">ggsave(<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"scatter_plot.pdf\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.92894280762565\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_ib7XHgMYW7V8jqTQpVyia6GU25icNg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAy34u8tx4u4aB0BOvhfL2bPkP59VjyoHaNSmJutoVxDbhrNvlvib7XHgMYW7V8jqTQpVyia6GU25icNg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"577\" style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u7ed8\u5236\u68ee\u6797\u56fe<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">res_single <- mr_singlesnp(mydata)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">mr_forest_plot(res_single)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">ggsave(<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"forest_plot.pdf\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9178082191780822\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_9QvQibRbhibwbhibgfB1KpDc84eDYQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAy34u8tx4u4aB0BOvhfL2bP5icu7WOg8CBceXdxZcamoWpEGTU79QvQibRbhibwbhibgfB1KpDc84eDYQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"584\" style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">#\u7ed8\u5236\u6f0f\u6597\u56fe<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">mr_funnel_plot(res_single)<\/span><\/code><code style=\"box-sizing: border-box;\"><span class=\"code-snippet_outer\">ggsave(<span class=\"code-snippet__string\" style=\"box-sizing: border-box;\">\"funnel_plot.pdf\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9612546125461254\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_fjvwhstG5XEOgdwP7fPjwFSGCADe6Q.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAy34u8tx4u4aB0BOvhfL2bP2A8jD85pCia5uJX1KCLibISBP8fjvwhstG5XEOgdwP7fPjwFSGCADe6Q\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"542\" style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5c0f\u679c\u4eca\u5929\u5bf9\u4e24\u6837\u672c\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u5206\u4eab\u5c31\u5230\u8fd9\u91cc\uff0c\u6709\u9700\u8981\u7684\u53ef\u4ee5\u501f\u9274\u5b66\u4e60\u5965\uff0c\u4e0d\u8981\u5fd8\u8bb0\u70b9\u8d5e\u5173\u6ce8\u5440\uff0c\u4e0b\u671f\u5728\u89c1\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\" \/><\/p>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"white-space: normal;\">\n<section style=\"box-sizing: border-box;max-width: 100%;\">\n<section>\n<section style=\"box-sizing: border-box;max-width: 100%;\">\n<section>\n<section style=\"box-sizing: border-box;max-width: 100%;\">\n<section>\n<section style=\"box-sizing: border-box;\">\n<section powered-by=\"xiumi.us\" style=\"box-sizing: border-box;\">\n<section style=\"line-height: 1.8;box-sizing: border-box;\">\n<section powered-by=\"xiumi.us\" style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section powered-by=\"xiumi.us\" style=\"font-size: 16px;box-sizing: border-box;\">\n<p style=\"text-align: center;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwNjE0MDY3MQ==&mid=2650750896&idx=2&sn=eedf639d72ed894b623b97cb453ec731&chksm=831a7820b46df136d60bbcd98da1545dc7cdc7d23013ee352ad58b8413bd8b74496a1cb24158&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" 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