{"id":50012,"date":"2024-06-16T09:48:48","date_gmt":"2024-06-16T01:48:48","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=50012"},"modified":"2024-06-16T09:48:48","modified_gmt":"2024-06-16T01:48:48","slug":"%e6%b8%a9%e5%b7%9e%e5%8c%bb%e7%a7%91%e5%a4%a7%e9%99%84%e5%b1%9e%e7%ac%ac%e4%ba%8c%e5%8c%bb%e9%99%a2%e5%bc%a0%e7%bb%b4%e6%ba%aa%e7%ad%89%e5%9b%a2%e9%98%9f1%e5%8c%ba7%e5%88%86%e6%96%87%e7%ab%a0-2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=50012","title":{"rendered":"\u6e29\u5dde\u533b\u79d1\u5927\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662\u5f20\u7ef4\u6eaa\u7b49\u56e2\u961f1\u533a7\u5206+\u6587\u7ae0\uff01\u94c1\u6b7b\u4ea1+\u591a\u7ec4\u5b66\u5206\u6790+\u5e72\u6e7f\u7ed3\u5408\uff0c\u975e\u80bf\u7624\u75be\u75c5\u4e5f\u540c\u6837\u7ed9\u529b\uff01"},"content":{"rendered":"


\n
\n<\/title><br \/>\n<meta charset=\"utf-8\"><br \/>\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,maximum-scale=1.0,user-scalable=0,viewport-fit=cover\"><\/p>\n<style>\n*{margin:0;padding:0}html{-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;line-height:1.6}img{z-index:999;position:relative;max-width:100%;margin:10px 0;}body{letter-spacing:.034em}h1,h2,h3,h4,h5,h6{font-weight:400;font-size:16px}a{color:#576b95;text-decoration:none;-webkit-tap-highlight-color:rgba(0,0,0,0)}td,th{word-wrap:break-word;padding:5px 10px;border:1px solid #DDD;}table{margin-bottom:10px;border-collapse:collapse;display:table;width:100%!important;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}.rich_media_area_primary{padding:20px 16px 12px;background-color:#fafafa}@media (max-width:375px){.rich_media_area_primary{padding:20px 60px 15px 60px}.rich_media_area_extra{padding:0 60px 21px 60px}}@media (min-width:1024px){.rich_media_area_primary_inner,.rich_media_area_extra_inner,body{max-width:677px;margin-left:auto;margin-right:auto}.rich_media_area_primary{padding-top:32px}}.rich_media{padding:20px;overflow:hidden;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}@media screen and (min-width:1024px){.rich_media_area_primary_inner,.rich_media_area_extra_inner{max-width:677px;margin-left:auto;margin-right:auto}.rich_media_area_primary{padding-top:32px}}.rich_media_content{overflow:hidden;color:#333;font-size:17px;word-wrap:break-word;-webkit-hyphens:auto;-ms-hyphens:auto;hyphens:auto;text-align:justify;position:relative;z-index:0}.rich_media_content *{max-width:100%!important;box-sizing:border-box!important;-webkit-box-sizing:border-box!important;word-wrap:break-word!important}.rich_media_content p{clear:both;min-height:1em}.rich_media_content em{font-style:italic}.rich_media_content fieldset{min-width:0}.rich_media_content .list-paddingleft-1,.rich_media_content .list-paddingleft-2,.rich_media_content .list-paddingleft-3{padding-left:2.2em}.rich_media_content .list-paddingleft-1 .list-paddingleft-2,.rich_media_content .list-paddingleft-2 .list-paddingleft-2,.rich_media_content .list-paddingleft-3 .list-paddingleft-2{padding-left:30px}.rich_media_content .list-paddingleft-1{padding-left:1.2em}.rich_media_content .list-paddingleft-3{padding-left:3.2em}.rich_media_content .code-snippet,.rich_media_content .code-snippet__fix{max-width:1000%!important}.rich_media_content .code-snippet *,.rich_media_content .code-snippet__fix *{max-width:1000%!important}.rich_media_title{font-size:22px;line-height:1.4;margin-bottom:13px;padding-bottom:13px;border-bottom:1px solid #e7e7eb;}@supports(-webkit-overflow-scrolling:touch){.rich_media_title{font-weight:700}}.rich_media_meta{display:inline-block;vertical-align:middle;padding:0 0 10px 0;font-size:15px;-webkit-tap-highlight-color:rgba(0,0,0,0)}.rich_media_meta.icon_appmsg_tag{margin-right:0px}.rich_media_meta.meta_tag_text{margin-right:0}.rich_media_meta_list em{font-style:normal}.rich_media_meta_text{color:#a5a5a5;}p{margin:0;}.msgBox{margin-top:20px;padding-top:20px;padding-left:50px;overflow:hidden;border-top:2px dashed #09a2ff;}.msg{padding-top:7px;clear:both;}.msgBody{float:right;width:100%;margin-left:55px;padding-bottom:15px;border-bottom:1px dashed #e0e0e0;}.userHeadImg{float:left;margin-left:-50px;}.userHeadImg img{width:40px;height:40px;margin-right:10px;border-radius:3px;}.userName{color:#888888;line-height:24px;font-size:14px;margin:5px 0 5px 0;height:24px;}.replyBody,.autherBody{color:#565656;font-size:15px;}.replyIcon{border-left:4px solid #33ab01;margin-right:5px;}.ad{text-decoration:none;color:#d6d4d4;font-size:12px;}.msgBodyReply{padding-top:5px;}.userName span{float:right;color:#afafaf;font-size:14px;}code{text-align:left;font-size:14px;display:block;white-space:pre;display:-webkit-box;display:-webkit-flex;display:flex;position:relative;}.code-snippet__fix{font-size:14px;margin:10px 0;display:block;color:#333;position:relative;background-color:rgba(0,0,0,0.03);border:1px solid #f0f0f0;border-radius:2px;display:-webkit-box;display:-webkit-flex;display:flex;padding-left:25px;line-height:26px}.code-snippet__fix code{text-align:left;font-size:14px;display:block;white-space:pre;display:-webkit-box;display:-webkit-flex;display:flex;position:relative;font-family:Consolas,\"Liberation Mono\",Menlo,Courier,monospace}.code-snippet__comment,.code-snippet__quote{color:#afafaf;font-style:italic}.code-snippet__keyword,.code-snippet__selector-tag,.code-snippet__subst{color:#ca7d37}.code-snippet__number,.code-snippet__literal,.code-snippet__variable,.code-snippet__template-variable,.code-snippet__tag .code-snippet__attr{color:#0e9ce5}.code-snippet__string,.code-snippet__doctag{color:#d14}.code-snippet__title,.code-snippet__section,.code-snippet__selector-id{color:#d14}.code-snippet__subst{font-weight:normal}.code-snippet__type,.code-snippet__class .code-snippet__title{color:#0e9ce5}.code-snippet__tag,.code-snippet__name,.code-snippet__attribute{color:#0e9ce5;font-weight:normal}.code-snippet__regexp,.code-snippet__link{color:#ca7d37}.code-snippet__symbol,.code-snippet__bullet{color:#d14}.code-snippet__built_in,.code-snippet__builtin-name{color:#ca7d37}.code-snippet__meta{color:#afafaf}.code-snippet__deletion{background:#fdd}.code-snippet__addition{background:#dfd}.code-snippet__emphasis{font-style:italic}.code-snippet__strong{font-weight:bold}.account_avatar{width:40px;height:40px;padding:0;}.account_info{display:-webkit-box;display:-webkit-flex;display:flex;-webkit-box-align:center;-webkit-align-items:center;padding:20px 0;align-items:center}.flex_bd{padding-left:14px;}.account_nickname{display:inline-block;vertical-align:middle;line-height:1.2;color:#576b95;font-size:14px}.account_desc{overflow:hidden;text-overflow:ellipsis;display:-webkit-box;-webkit-box-orient:vertical;-webkit-line-clamp:1;color:rgba(0,0,0,0.3);font-size:14px;line-height:1.2;padding-top:.4em}.msg_source_url{text-align:left;word-break:break-all;margin-top:20px;}.msg_source_url a{padding-right:10px;}.msg_source_url .url_text{color:#a8a8a8;}.video-desc{font-size:14px;margin-top:15px;color:#6c6c6c;}.msg_source_url{text-align:left;}.original_primary_card_tips{color:rgba(0,0,0,0.3);line-height:1.4;font-size:15px;}.weui-flex__item{margin-bottom:20px;padding:20px 16px;margin-top:16px;line-height:1.4;align-items:center;background-color:#f7f7f7;border-radius:8px;position:relative;}.original_primary_desc{color:rgba(0,0,0,0.5);font-size:14px;padding-top:4px;width:auto;overflow:hidden;text-overflow:ellipsis;}.msgBodyReplyList{border-top:1px solid #e1e1e1;margin-top:10px;}.msgBodyReplyListTop{border-top:0;}.reply_like_num{float:right;font-size:14px;color:#c7c7c7;}.msgData{margin-top:20px;color:#626262;}.msgData span{font-size:14px;padding-right:15px;}.msgData .likes{float:right;padding-right:0;}.js_text_content p{font-size:18px;}.rich_media_meta_link{font-size:15px;}blockquote {padding-left: 10px;border-left: 3px solid #dbdbdb;color: rgba(0,0,0,0.5);font-size: 15px;padding-top: 4px;margin: 1em 0;}.video_iframe{width:500px;height:400px;}.blockquote_info{color:#b5b5b5;margin-top:10px;}#copyright_logo{color:#bdbdbd;}.rich_media_meta_list{margin-bottom:10px;}.reprint{background:#efefef;border-radius:5px;padding:8px;color:#1f1f1f;}.reprint a{word-break:break-all;}.topic{color:#8e8e8e;background:#f7f7f7;border-radius:5px;padding:10px 8px;}.topic a{padding-right:5px;}.topic p{margin-bottom:5px;}\n<\/style>\n<link href=\"https:\/\/www.juyifx.cn\/config\/css\/wxArticle.css\" rel=\"stylesheet\"\/>\n<\/head><script>\nvar data={\"mp\":\"\u751f\u4fe1\u679c\",\"title\":\"\u6e29\u5dde\u533b\u79d1\u5927\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662\u5f20\u7ef4\u6eaa\u7b49\u56e2\u961f1\u533a7\u5206+\u6587\u7ae0\uff01\u94c1\u6b7b\u4ea1+\u591a\u7ec4\u5b66\u5206\u6790+\u5e72\u6e7f\u7ed3\u5408\uff0c\u975e\u80bf\u7624\u75be\u75c5\u4e5f\u540c\u6837\u7ed9\u529b\uff01\",\"time\":\"2024-02-23 19:00:45\",\"timeStamp\":\"1708686045\"};\n<\/script><br \/>\n<body><\/p>\n<div class=\"rich_media\">\n<h1 class=\"rich_media_title\" id=\"activity-name\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247500635&idx=1&sn=8c1f82f996d36f8a84f4373539dc864a&chksm=cf7f539ef808da8876a690fbfb2b764aea7fa8367c8a0ea52daac04b1298e59e64b8d3f38955#rd\" target=\"_blank\" rel=\"noopener\">\u6e29\u5dde\u533b\u79d1\u5927\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662\u5f20\u7ef4\u6eaa\u7b49\u56e2\u961f1\u533a7\u5206+\u6587\u7ae0\uff01\u94c1\u6b7b\u4ea1+\u591a\u7ec4\u5b66\u5206\u6790+\u5e72\u6e7f\u7ed3\u5408\uff0c\u975e\u80bf\u7624\u75be\u75c5\u4e5f\u540c\u6837\u7ed9\u529b\uff01<\/a><\/h1>\n<div id=\"meta_content\" class=\"rich_media_meta_list\"><span class=\"rich_media_meta rich_media_meta_text\">\u5c0f\u9014  <\/span><span class=\"rich_media_meta rich_media_meta_nickname\" id=\"profileBt\"><a href=\"javascript:void(0);\" class=\"wx_tap_link js_wx_tap_highlight weui-wa-hotarea\" id=\"js_name\">\u751f\u4fe1\u679c  <\/a><\/span><em id=\"publish_time\" class=\"rich_media_meta rich_media_meta_text\">2024-02-23 19:00:45<\/em><\/div>\n<p><content><\/p>\n<div class=\"reprint\">\n<p>\u8f6c\u81ea\u516c\u4f17\u53f7\uff1a\u751f\u4fe1\u8def<br \/><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzk0MDQ2MTU0Mg==&mid=2247492703&idx=1&sn=577e5463ade3ef1c680427cba86a29d9\" target=\"_blank\" title=\"\u9605\u8bfb\u539f\u6587\" rel=\"noopener\">http:\/\/mp.weixin.qq.com\/s?__biz=Mzk0MDQ2MTU0Mg==&mid=2247492703&idx=1&sn=577e5463ade3ef1c680427cba86a29d9<\/a><\/p>\n<\/div>\n<p style=\"text-align: center;\" data-mpa-powered-by=\"yiban.io\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100015224\" data-ratio=\"0.2222222222222222\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_r0Gd7iaumIGMiaia97aHFV15nrpdzw-19.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxQW8Zek7Noib2uBhB3ZE3yMxI2Hfic7cGTdPYiacicg47jficdr5BVr0Gd7iaumIGMiaia97aHFV15nrpdzw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"900\" style=\"\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">\u89c9\u5f97\u751f\u4fe1\u592a\u96be\u4e86\uff1f\u90a3\u662f\u4f60\u8fd8\u6ca1\u6709\u627e\u5bf9\u65b9\u6cd5\u4e0e\u5957\u8def\u54e6~\u5c0f\u9014\u4eca\u5929\u53d1\u73b0\u4e86\u4e00\u7bc7\u5b9d\u85cf\u6587\u7ae0\uff0c\u8f7b\u8f7b\u677e\u677e\u62ff\u4e0b7.7\u5206\u7684\u4e00\u533a\u6587\u7ae0\uff0c\u4e00\u8d77\u5f80\u4e0b\u770b\u5427\uff01\uff01\uff01<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009040\" data-ratio=\"0.9728434504792333\" data-type=\"png\" data-w=\"626\" height=\"88 .1300048828125\" width=\"90 .60000610351562\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_yGCFcFUy4AAU9ezrmVesQw0j3tSjzA-4.png?resize=90%2C88\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LSQ1wtQyiaX6kzvJuBdxkmwfuqLZb93MNSsLnzqqzaoMacwKyGCFcFUy4AAU9ezrmVesQw0j3tSjzA\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u6b64\u7bc7\u6587\u7ae0\u4e2d\u7814\u7a76\u4eba\u5458\u7b5b\u9009\u4e86\u4e0e\u54ee\u5598\u60a3\u8005\u94c1\u6b7b\u4ea1\u76f8\u5173\u7684\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\u3002\u4f7f\u7528WGCNA\u5206\u6790\u4e86\u8be5\u57fa\u56e0\u5728\u4e0d\u540c\u6837\u672c\u4e4b\u95f4\u7684\u57fa\u56e0\u5173\u8054\u6a21\u5f0f\u3002\u5728\u673a\u5236\u4e0a\uff0c\u63a2\u8ba8\u4e86\u5176\u5bf9\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de\u4e2d\u8102\u8d28\u8fc7\u6c27\u5316\u548c\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u7684\u5f71\u54cd\u3002\u4e3a\u54ee\u5598\u7684\u8bca\u65ad\u3001\u6cbb\u7597\u548c\u5206\u578b\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5e76\u786e\u5b9a\u4e86\u94c1\u6b7b\u4ea1\u7684\u4e00\u4e2a\u91cd\u8981\u8c03\u63a7\u56e0\u5b50\u3002<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u8fd9\u4e2a\u5b9d\u85cf\u6587\u7ae0\u4ece\u516c\u5171\u6570\u636e\u5e93\u51fa\u53d1\uff0c\u7ed3\u5408\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u5bf9\u75be\u75c5\u53d1\u751f\u673a\u5236\u505a\u51fa\u63a2\u7d22\uff0c\u5185\u5bb9\u5145\u5b9e\uff0c\u65b9\u6cd5\u5177\u4f53\u53ef\u884c\uff0c\u503c\u5f97\u5927\u5bb6\u4f19\u6765\u5b66\u4e60\u501f\u9274\u5662\uff01\uff01\uff01\u7ee7\u7eed\u5f80\u4e0b\u6df1\u5165\u5b66\u4e60\u5427~<\/span><\/p>\n<p style=\"outline: 0px;font-family: system-ui, -apple-system, "system-ui", "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);visibility: visible;margin-bottom: 24px;\"><span style=\"outline: 0px;font-size: 16px;visibility: visible;\"><span style=\"outline: 0px;color: rgb(0, 82, 255);visibility: visible;\"><strong style=\"outline: 0px;visibility: visible;\">\uff08ps\uff1a\u5bf9\u4e8e\u90a3\u4e9b\u6e34\u671b\u521b\u65b0\u7684\u670b\u53cb\u4eec\uff0c\u5feb\u6765\u627e\u5c0f\u9014\u5427\uff01\u8fd9\u91cc\u6709\u751f\u7269\u4fe1\u606f\u5b66\u7684\u6700\u65b0\u70ed\u70b9\u65b9\u5411\uff0c\u8fd8\u6709\u6e90\u6e90\u4e0d\u65ad\u7684\u521b\u65b0\u7075\u611f\u2026\u611f\u5174\u8da3\u7684\u8bdd\uff0c\u5c31\u5728\u8d76\u7d27\u8054\u7cfb\u6211\u5427\uff01\uff09    <\/strong><\/span><\/span><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016827\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_B2jkicacLzPjw4xMSqVvoucZjonVDA-11.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 195px;height: 195px;\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009038\" data-ratio=\"0.4046296296296296\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_SKhroH1yHX0AINCWUbV9EFfJqHQFTw-4.png?resize=553%2C224\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LSQ1wtQyiaX6kzvJuBdxkmwfH4KcIibhwOU4XHs98mEKrBJUTSKhroH1yHX0AINCWUbV9EFfJqHQFTw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"224 .07000732421875\" style=\"height: auto !important;\" width=\"553 .0800170898438\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u9898\u76ee\uff1a\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u94c1\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0AKR1C3\u4f5c\u4e3a\u54ee\u5598\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\u53ca\u5176\u5728BEAS-2B\u7ec6\u80de\u4e2d\u7684\u9274\u5b9a<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u6742\u5fd7\uff1aComputers in Biology and Medicine<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=7.7<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e743\u6708<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 18px;\"><strong><span style=\"font-size: 18px;color: rgb(0, 82, 255);\">\u7814\u7a76\u80cc\u666f<\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u54ee\u5598\u662f\u4e00\u79cd\u6c14\u9053\u58c1\u7684\u6162\u6027\u590d\u6742\u708e\u75c7\u6027\u75be\u75c5\uff0c\u4e5f\u662f\u513f\u7ae5\u65f6\u671f\u6700\u5e38\u89c1\u7684\u6162\u6027\u80ba\u90e8\u75be\u75c5\uff0c\u5f71\u54cd\u5168\u7403\u8d85\u8fc73.5\u4ebf\u4eba\u3002\u5b83\u662f\u4e00\u79cd\u590d\u6742\u7684\u57fa\u56e0-\u73af\u5883\u76f8\u4e92\u4f5c\u7528\uff0c\u6d89\u53ca\u5f62\u6210\u5176\u53d1\u75c5\u673a\u5236\u7684\u591a\u4e2a\u4fe1\u53f7\u901a\u8def\u3002\u54ee\u5598\u4ee5\u652f\u6c14\u7ba1\u91cd\u5851\u548c\u6c14\u9053\u9ad8\u53cd\u5e94\u6027\u4e3a\u7279\u5f81;\u56e0\u6b64\uff0c\u54ee\u5598\u7684\u8bca\u65ad\u548c\u9884\u540e\u4e0e\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de\u635f\u4f24\u7a0b\u5ea6\u5bc6\u5207\u76f8\u5173\u3002\u6c14\u9053\u4e0a\u76ae\u7ec6\u80de\u88ab\u8ba4\u4e3a\u662f\u54ee\u5598\u708e\u75c7\u3001\u514d\u75ab\u548c\u518d\u751f\u8fc7\u7a0b\u7684\u4f18\u5148\u53cd\u5e94\u8005\u3002\u7531\u4e8e\u75be\u75c5\u7684\u590d\u6742\u6027\u548c\u5f02\u8d28\u6027\uff0c\u60a3\u8005\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u901a\u5e38\u4f1a\u9047\u5230\u56f0\u96be\u3002\u6839\u636e\u60a3\u8005\u5728\u63a5\u53d7\u76ae\u8d28\u7c7b\u56fa\u9187\u6cbb\u7597\u540e\u662f\u5426\u4ecd\u6709\u6301\u7eed\u75c7\u72b6\uff0c\u901a\u5e38\u5c06\u60a3\u8005\u5206\u4e3a\u91cd\u5ea6\u96be\u6cbb\u6027\u54ee\u5598(SA)\u6216\u5f97\u5230\u63a7\u5236\u7684\u6301\u7eed\u6027\u8f7b\u5ea6\u54ee\u5598(MA)\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u80fd\u591f\u63d0\u9ad8\u54ee\u5598\u8bca\u65ad\u548c\u6cbb\u7597\u6548\u7387\u7684\u65b0\u578b\u9776\u5411\u65b9\u6cd5\u3002<\/span><span style=\"font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;font-size: 16px;\">        <\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"color: rgb(0, 82, 255);\"><strong><span style=\"color: rgb(0, 82, 255);font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;font-size: 18px;\">\u6570\u636e\u6765\u6e90<\/span><\/strong><\/span><\/p>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" style=\"border-width: initial;border-style: none;border-color: initial;border-collapse: collapse;width: 100%;\">\n<tbody>\n<tr>\n<td width=\"102\" valign=\"top\" style=\"width:76.3pt;background:#4472C4;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p><span style=\"font-size: 16px;\">\u6570\u636e\u96c6\/\u961f\u5217<\/span><\/p>\n<\/td>\n<td width=\"94\" valign=\"top\" style=\"width:70.85pt;background:#4472C4;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p><span style=\"font-size: 16px;\">\u6570\u636e\u5e93<\/span><\/p>\n<\/td>\n<td width=\"132\" valign=\"top\" style=\"width:99.25pt;background:#4472C4;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p><span style=\"font-size: 16px;\">\u6570\u636e\u7c7b\u578b<\/span><\/p>\n<\/td>\n<td width=\"240\" valign=\"top\" style=\"width:179.7pt;background:#4472C4;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p><span style=\"font-size: 16px;\">\u8be6\u7ec6\u4fe1\u606f<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"102\" valign=\"top\" style=\"width:76.3pt;background:#D9E2F3;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p><span style=\"font-size: 16px;\">GDS4896<\/span><\/p>\n<\/td>\n<td width=\"94\" valign=\"top\" style=\"width:70.85pt;background:#D9E2F3;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:none;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p><span style=\"font-size: 16px;\">GEO<\/span><\/p>\n<\/td>\n<td width=\"132\" valign=\"top\" style=\"width:99.25pt;background:#D9E2F3;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:none;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p><span style=\"font-size: 16px;\">RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n<td width=\"240\" valign=\"top\" style=\"width:179.7pt;background:#D9E2F3;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:none;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p><span style=\"font-size: 16px;\">54\u4efd\u6837\u672c<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"102\" valign=\"top\" style=\"width:76.3pt;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p><span style=\"font-size: 16px;\">GSE64913<\/span><\/p>\n<\/td>\n<td width=\"94\" valign=\"top\" style=\"width:70.85pt;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:none;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p><span style=\"font-size: 16px;\">GEO<\/span><\/p>\n<\/td>\n<td width=\"132\" valign=\"top\" style=\"width:99.25pt;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:none;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p><span style=\"font-size: 16px;\">RNA-seq\u6570\u636e<\/span><\/p>\n<\/td>\n<td width=\"240\" valign=\"top\" style=\"width:179.7pt;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:none;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p><span style=\"font-size: 16px;\">–<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"color: rgb(0, 82, 255);\"><strong><span style=\"color: rgb(0, 82, 255);font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;font-size: 18px;\">\u7814\u7a76\u601d\u8def<\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u672c\u7814\u7a76\u4f7f\u7528R\u8f6f\u4ef6\u5bf9\u54ee\u5598\u548c\u94c1\u6b7b\u4ea1\u6570\u636e\u96c6\u8fdb\u884c\u4e86\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\uff0c\u4ee5\u786e\u5b9a\u5019\u9009\u94c1\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0\u3002\u91c7\u7528\u52a0\u6743\u57fa\u56e0\u5171\u8868\u8fbe\u7f51\u7edc\u5206\u6790\u65b9\u6cd5\u8bc6\u522b\u5171\u8868\u8fbe\u57fa\u56e0\u3002\u91c7\u7528\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u3001the Kyoto encyclopedia of genes and genomes\u548cgene ontology enrichment analysis\u9274\u5b9a\u5019\u9009\u57fa\u56e0\u7684\u6f5c\u5728\u529f\u80fd\u3002\u4f7f\u7528\u5c0f\u5e72\u6270rna\u548c\u8d28\u7c92\u5728\u4eba\u652f\u6c14\u7ba1\u4e0a\u76ae\u7ec6\u80de(BEAS-2B)\u4e2d\u6c89\u9ed8\u548c\u4e0a\u8c03\u5019\u9009\u57fa\u56e0\u7684\u8868\u8fbe\u6765\u9a8c\u8bc1\u5206\u6790\u7ed3\u679c\u3002\u68c0\u6d4b\u94c1\u6b7b\u4ea1\u7279\u5f81\u6c34\u5e73\u3002\u5bf9\u54ee\u5598\u6570\u636e\u96c6GDS4896\u8fdb\u884c\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u663e\u793a\uff0c\u91cd\u5ea6\u96be\u6cbb\u6027\u54ee\u5598\u548c\u63a7\u5236\u7684\u6301\u7eed\u6027\u8f7b\u5ea6\u54ee\u5598(MA)\u60a3\u8005\u5916\u5468\u8840\u4e2d\u919b\u916e\u8fd8\u539f\u9176\u5bb6\u65cf1\u6210\u5458C3 (AKR1C3)\u57fa\u56e0\u6c34\u5e73\u663e\u8457\u4e0a\u8c03\u3002\u8bca\u65ad\u54ee\u5598\u548cMA\u7684AUC\u503c\u5206\u522b\u4e3a0.823\u548c0.915\u3002\u4f7f\u7528GSE64913\u6570\u636e\u96c6\u9a8c\u8bc1AKR1C3\u7684\u8bca\u65ad\u4ef7\u503c\u3002AKR1C3\u57fa\u56e0\u6a21\u5757\u5728MA\u4e2d\u5f88\u660e\u663e\uff0c\u5e76\u901a\u8fc7\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u548c\u4ee3\u8c22\u8fc7\u7a0b\u53d1\u6325\u529f\u80fd\u3002\u8fc7\u8868\u8fbeAKR1C3\u53ef\u4e0b\u8c03\u94c1\u6b7b\u4ea1\u6307\u6807\uff0c\u6c89\u9ed8AKR1C3\u53ef\u4e0a\u8c03\u94c1\u6b7b\u4ea1\u6307\u6807\u3002\u94c1\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0AKR1C3\u53ef\u4f5c\u4e3a\u54ee\u5598\u5c24\u5176\u662fMA\u7684\u8bca\u65ad\u751f\u7269\u6807\u5fd7\u7269\uff0c\u8c03\u63a7BEAS-2B\u7ec6\u80de\u7684\u94c1\u6b7b\u4ea1\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"color: rgb(0, 82, 255);\"><strong><span style=\"color: rgb(0, 82, 255);font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;font-size: 18px;\">\u4e3b\u8981\u7ed3\u679c<\/span><\/strong><\/span><br \/><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);\">1.AKR1C3\u662f\u552f\u4e00\u4e0e\u94c1\u6b7b\u4ea1\u76f8\u5173\u7684DEG\uff0c\u4e5f\u662f\u54ee\u5598\u9884\u540e\u7684\u751f\u7269\u6807\u5fd7\u7269<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u4e0b\u8f7d\u4eba\u7c7b\u54ee\u5598\u57fa\u56e0\u6570\u636e\u96c6GDS4896\u7684\u539f\u59cb\u6587\u4ef6\uff0c\u5c06\u63a2\u9488\u66ff\u6362\u4e3a\u57fa\u56e0\u540d\u79f0\uff0c\u5f97\u5230\u540c\u4e00\u57fa\u56e0\u7684\u5e73\u5747\u503c\u3002\u91c7\u7528GDS4896\u57fa\u56e0\u96c6\u5bf9SA\u548cMA\u60a3\u513f\u7684\u767d\u7ec6\u80de\u8fdb\u884c\u5206\u6790\u3002GDS4896\u5171\u7eb3\u516554\u4efd\u6837\u672c\uff0c\u5305\u62ec18\u4f8b\u5065\u5eb7\u8005\u300119\u4f8bMA\u60a3\u8005\u548c17\u4f8bSA\u60a3\u8005\u3002\u4ee5\u662f\u5426\u5b58\u5728\u54ee\u5598\u8fdb\u884c\u5206\u7c7b\uff0cKEGG\u901a\u8def\u5206\u6790\u663e\u793a\uff0cGDS4896\u7684\u57fa\u56e0\u5728\u591a\u6761\u901a\u8def\u4e2d\u5bcc\u96c6(P \uff1c0.05, FDR\uff1c0.25)\uff0c\u5305\u62ec\u4e1d\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176(mitogen-activated protein kinases, MAPK)\u901a\u8def\u3001Th17\u901a\u8def\u3001\u8102\u80aa\u9178\u4ee3\u8c22\u548c\u94c1\u6b7b\u4ea1(\u56fe1a)\u3002   <\/span><o:page><\/o:page><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u540c\u65f6\uff0c\u54ee\u5598\u7ec4\u548c\u5bf9\u7167\u7ec4\u4e4b\u95f4\u670956\u4e2a\u57fa\u56e0\u5b58\u5728\u663e\u8457\u5dee\u5f02(logFC\u7edd\u5bf9\u503c\uff1e0.5\u548c\u8c03\u6574\u540e\u7684p\u503c\uff1c0.05)\u3002\u5bf9\u524d\u671f\u94c1\u6b7b\u4ea1\u6570\u636e\u5e93\u8fdb\u884c\u91cd\u590d\u503c\u7ec4\u88c5\u548c\u5220\u9664\u540e\u5f97\u5230\u5305\u542b259\u4e2a\u9a71\u52a8\u57fa\u56e0\u3001\u6291\u5236\u57fa\u56e0\u548c\u6807\u5fd7\u57fa\u56e0\u7684\u94c1\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0\u96c6\u3002\u7ef4\u6069\u56fe\u663e\u793a\uff0c\u53ea\u6709\u4e00\u4e2a\u94c1\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0AKR1C3\u5728\u54ee\u5598\u7ec4\u548c\u5bf9\u7167\u7ec4\u4e4b\u95f4\u5b58\u5728\u5dee\u5f02\u8868\u8fbe\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u68c0\u6d4bAKR1C3\u7684\u5dee\u5f02\u8868\u8fbe\uff0c\u6211\u4eec\u4f7f\u7528\u94c1\u6b7b\u4ea1\u57fa\u56e0\u96c6\u6784\u5efa\u4e86\u6bcf\u4e24\u7ec4\u5dee\u5f02\u57fa\u56e0\u7684\u7ef4\u6069\u56fe\u3002\u6211\u4eec\u7684\u7ed3\u679c\u8868\u660e\uff0cAKR1C3\u5728MA\u7ec4\u548c\u5bf9\u7167\u7ec4\u4e4b\u95f4\u4ee5\u53caSA\u7ec4\u548cMA\u7ec4\u4e4b\u95f4\u663e\u793a\u51fa\u663e\u8457\u5dee\u5f02(\u56fe1b)\u3002\u4e0e\u5065\u5eb7\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0cAKR1C3\u5728\u54ee\u5598\u60a3\u8005\u4e2d\u663e\u8457\u4e0a\u8c03\uff0c\u4e14\u4e0e\u54ee\u5598\u4e25\u91cd\u7a0b\u5ea6\u65e0\u5173\u3002\u6709\u8da3\u7684\u662f\uff0cAKR1C3\u5728MA\u7ec4\u4e2d\u7684\u8868\u8fbe\u660e\u663e\u9ad8\u4e8eSA\u7ec4(\u56fe1c)\u3002<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u4ee5AKR1C3\u8868\u8fbe\u6c34\u5e73\u4f5c\u4e3a\u9884\u6d4b\u56e0\u5b50\uff0c\u6784\u5efaROC\u66f2\u7ebf\u5e76\u8ba1\u7b97AUC\u503c\u3002AKR1C3\u5bf9\u54ee\u5598\u5177\u6709\u826f\u597d\u7684\u9884\u6d4b\u6548\u80fd(AUC = 0.823;\u7f6e\u4fe1\u533a\u95f4:0.713\u20140.932)\u3002\u5728\u54ee\u5598\u7ec4\u95f4\uff0cMA\u5177\u6709\u66f4\u9ad8\u7684\u8bca\u65ad\u4ef7\u503c(AUC = 0.915;CI: 0.826 ~ 1.000)\u5747\u9ad8\u4e8eSA (AUC = 0.719;CI: 0.546 ~ 0.892)(\u56fe1d)\u3002\u91c7\u7528GSE64913\u8f6f\u4ef6\u8fdb\u884c\u5dee\u5f02\u6027\u6bd4\u8f83\u548cROC\u66f2\u7ebf\u6784\u5efa\uff0c\u5bf9\u7ed3\u679c\u8fdb\u884c\u9a8c\u8bc1\u3002\u8be5\u6570\u636e\u5e93\u7528\u4e8e\u5206\u6790\u5916\u5468\u6c14\u9053\u4e0a\u76ae\u57fa\u56e0\u8868\u8fbe\uff0c\u5305\u62ecSA\u7ec4\u548c\u5bf9\u7167\u7ec4\u3002AKR1C3\u5728\u54ee\u5598\u60a3\u8005\u548c\u5bf9\u7167\u7ec4\u4e4b\u95f4\u5dee\u5f02\u6709\u7edf\u8ba1\u5b66\u610f\u4e49(AUC = 0.640;CI: 0.504-0.777)(\u56fe1e)\u3002   <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009041\" data-ratio=\"0.6907407407407408\" data-type=\"png\" data-w=\"1080\" height=\"382 .2099914550781\" width=\"553 .6799926757812\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_NqljcytnrL52a06y2xIQ2uMvsojcvg-4.png?resize=553%2C382\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LSQ1wtQyiaX6kzvJuBdxkmwficr0PtJ6fwvt3DhmKWvStukbicNqljcytnrL52a06y2xIQ2uMvsojcvg\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;\">\u56fe 1 AKR1C3\u5728\u54ee\u5598\u4e2d\u7684\u9884\u540e\u4ef7\u503c<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);\">2.\u901a\u8fc7WGCNA\u8bc6\u522b\u4e0eAKR1C3\u76f8\u5173\u7684\u6a21\u5757<\/span><br \/><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u4e3a\u4e86\u83b7\u5f97AKR1C3\u7684\u5171\u8868\u8fbe\u57fa\u56e0\uff0c\u8fdb\u4e00\u6b65\u4f7f\u7528R\u8f6f\u4ef6\u5bf9GDS4896\u6570\u636e\u96c6\u8fdb\u884cWGCNA\u5206\u6790\u3002\u5728\u5254\u96645\u4e2a\u5f02\u5e38\u503c\u540e\uff0c\u5c0610\u4f5c\u4e3a\u8f6f\u9608\u503c\uff0c\u8fbe\u5230\u90bb\u63a5\u754c\u503c0.85(\u56fe2a)\u3002\u968f\u540e\u5c06100\u8bbe\u4e3a\u6700\u5c0f\u7684\u57fa\u56e0\u6a21\u5757\uff0c\u6784\u5efa\u805a\u7c7b\u6811\u56fe\uff0c\u4ece\u4e2d\u8bc6\u522b\u51fa19\u4e2a\u8c03\u63a7\u6a21\u5757(\u56fe2b)\u3002<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u6a21\u5757\u4e0e\u54ee\u5598\u4e25\u91cd\u7a0b\u5ea6\u4e4b\u95f4\u7684\u5173\u8054\u5982\u56fe2c\u6240\u793a\u3002\u9ed1\u8272\u548c\u7eff\u9ec4\u8272\u6a21\u5757\u8868\u793a\u4e0e\u5bf9\u7167\u7ec4\u7684\u76f8\u5173\u6027\u6700\u9ad8(\u8d1f\u503c\u7b49\u4e8e\u603b\u54ee\u5598)\u3002\u6b64\u5916\uff0c\u9ed1\u8272\u6a21\u5757\u5bf9\u91cd\u5ea6\u54ee\u5598\u81f3\u5173\u91cd\u8981(cor = 0.61;P = 3 \u00d7 10 – 6)\uff0c\u800c\u7eff\u8272-\u9ec4\u8272\u6a21\u5757\u5bf9\u8f7b\u5ea6\u54ee\u5598\u5f88\u91cd\u8981(cor = 0.5;P = 2 \u00d7 10\u22124)\u3002\u57fa\u56e0\u96c6\u548c\u54ee\u5598\u8868\u578b\u5728\u9ed1\u8272\u548c\u7eff\u8272-\u9ec4\u8272\u6a21\u5757\u4e2d\u663e\u8457\u76f8\u5173(cor = 0.51;P = 1.7 \u00d7 10\u221237,cor = 0.51;P = 2.1 \u00d7 10\u221220)(\u56fe2d)\u3002\u6b64\u5916\uff0cAKR1C3\u4ec5\u51fa\u73b0\u5728\u7eff\u8272-\u9ec4\u8272\u6a21\u5757\u4e2d\uff0c\u8be5\u6a21\u5757\u5305\u542b\u4ece\u9ed1\u8272\u6a21\u5757\u5206\u79bb\u51fa\u7684287\u4e2a\u57fa\u56e0(\u56fe2e)\u3002\u5176\u4e2d\uff0cAKR1C3\u7b4911\u4e2a\u57fa\u56e0\u5728\u54ee\u5598\u4e2d\u5b58\u5728\u5dee\u5f02\u8868\u8fbe\u3002<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u4f7f\u7528STING\u6570\u636e\u5e93\u5206\u6790\u7eff-\u9ec4\u6a21\u5757\u4e2d\u7684\u57fa\u56e0\uff0c\u5e76\u4f7f\u7528Cytoscape\u53ef\u89c6\u5316\u5efa\u7acbPPI\u7f51\u7edc\u3002\u8282\u70b9\u95f4\u7ebf\u7684\u7c97\u7ec6\u548c\u989c\u8272\u8868\u793a\u57fa\u56e0\u7684\u7efc\u5408\u5f97\u5206\u3002\u7eff\u8272-\u9ec4\u8272\u6a21\u5757\u4e2d\u768412\u4e2a\u86cb\u767d\u4e0eAKR1C3\u7ed3\u5408\uff0c\u5982\u56fe2f\u6240\u793a\u3002\u5176\u4e2d\uff0cAKR1C4\u548cPTGDS\u4e0eAKR1C3\u7684\u76f8\u5173\u6027\u66f4\u5f3a\u3002   <\/span><o:page><\/o:page><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u901a\u8fc7KEGG\u548cGO\u5206\u6790\u786e\u5b9aAKR1C3\u6240\u5728\u57fa\u56e0\u6a21\u5757\u7684\u6f5c\u5728\u901a\u8def\u3002KEGG\u5728\u4ee3\u8c22\u76f8\u5173\u901a\u8def\u4e2d\u663e\u8457\u5bcc\u96c6\uff0c\u5305\u62ec\u560c\u5464\u4ee3\u8c22\u3001\u4ee3\u8c22\u901a\u8def\u3001\u8102\u80aa\u9178\u964d\u89e3\u3001\u8102\u80aa\u7ec6\u80de\u4e2d\u8102\u80aa\u5206\u89e3\u7684\u8c03\u8282\u548c\u80c6\u56fa\u9187\u4ee3\u8c22(\u56fe2g)\u3002GO\u6570\u636e\u5e93\u7684\u8fdb\u4e00\u6b65\u5206\u6790\u663e\u793a\uff0c\u6700\u4e3b\u8981\u7684\u7ec6\u80de\u6210\u5206\u662f\u7ec6\u80de\u8d28\u3001\u5185\u819c\u7cfb\u7edf\u3001\u56ca\u6ce1\u548c\u7ec6\u80de\u5916\u6d3b\u6027\u3002\u5728\u751f\u7269\u8fc7\u7a0b\u4e2d\uff0c\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u4ee5\u53ca\u8102\u8d28\u4ee3\u8c22\u548c\u6c27\u5316\u8fd8\u539f\u8fc7\u7a0b\u4e0e\u8be5\u6a21\u5757\u6709\u660e\u786e\u7684\u5173\u8054\u3002\u5728\u5206\u5b50\u529f\u80fd\u4e0a\uff0c\u8be5\u6a21\u5757\u4e0e\u9176\u8868\u73b0\u51fa\u663e\u8457\u7684\u76f8\u5173\u6027\uff0c\u5982\u50ac\u5316\u6d3b\u6027\u3001\u9176\u8c03\u8282\u6d3b\u6027\u3001\u8102\u8d28\u7ed3\u5408\u3001\u6c27\u5316\u8fd8\u539f\u9176\u6d3b\u6027\u4ee5\u53ca\u4ee3\u8c22\u548c\u6c27\u5316\u751f\u7269\u8fc7\u7a0b(\u56fe2h)<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009039\" data-ratio=\"1.146002317497103\" data-type=\"png\" data-w=\"863\" height=\"494 .53997802734375\" width=\"431 .53997802734375\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_Mn0L54icKBiarD52OIFpvBW0zvIJ9w-4.png?resize=431%2C494\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LSQ1wtQyiaX6kzvJuBdxkmwfuUvbRouibG2lhiayrQaF8HBcvN2sMn0L54icKBiarD52OIFpvBW0zvIJ9w\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;\">\u56fe2\u4f7f\u7528GDS4896\u6570\u636e\u96c6\u7684AKR1C3\u7684WGCNA<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);\">3.akr1c3\u7684\u8868\u8fbe\u53ef\u4fdd\u62a4BEAS-2B\u7ec6\u80de\u514d\u4e8e\u94c1\u6b7b\u4ea1<\/span><br \/><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u5728BEAS-2B\u7ec6\u80de\u4e2d\uff0c\u901a\u8fc7sirna\u6c89\u9ed8AKR1C3\u548c\u8d28\u7c92\u8fc7\u8868\u8fbeAKR1C3\uff0c\u89c2\u5bdfAKR1C3\u5bf9\u94c1\u6b7b\u4ea1\u7684\u5f71\u54cd\u3002si-AKR1C3-1\u548csi-AKR1C3-2\u5728mRNA\u548c\u86cb\u767d\u6c34\u5e73\u5747\u663e\u793a\u51fa\u826f\u597d\u7684AKR1C3\u6c89\u9ed8\u6548\u7387\u3002\u968f\u673a\u9009\u53d6si-AKR1C3-1\u8fdb\u884c\u540e\u7eed\u5b9e\u9a8c\u3002\u7ed3\u679c\u663e\u793a\uff0cpcDNA3.1-AKR1C3\u663e\u8457\u4e0a\u8c03BEAS-2B\u7ec6\u80de\u4e2dAKR1C3\u7684\u8868\u8fbe(\u56fe3a)\u3002<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">WGCNA\u7ed3\u679c\u8868\u660e\uff0cAKR1C3\u901a\u8fc7\u5f71\u54cd\u8102\u8d28\u4ee3\u8c22\u548c\u9176\u76f8\u5173\u7684\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u5728\u54ee\u5598\u548c\u94c1\u6b7b\u4ea1\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002Fe2+\u548c\u8102\u8d28\u8fc7\u6c27\u5316\u7269\u5728\u94c1\u6b7b\u4ea1\u4e2d\u81f3\u5173\u91cd\u8981\u3002\u5c06ferroOrange\u548cLiperfluo\u63a2\u9488\u5171\u67d3BEAS-2B\u7ec6\u80de\u540e\uff0c\u901a\u8fc7\u5171\u805a\u7126\u663e\u5fae\u955c\u62cd\u6444\u7ec6\u80de\u7167\u7247\u3002\u8367\u5149\u56fe\u50cf\u663e\u793a\uff0c\u94c1\u79bb\u5b50\u548c\u8102\u8d28\u8fc7\u6c27\u5316\u7269\u90fd\u5b58\u5728\u4e8e\u7ec6\u80de\u8d28\u7684\u76f8\u4f3c\u4f4d\u7f6e(\u56fe3b)\u3002\u5b9a\u91cf\u5206\u6790\u663e\u793a\uff0c\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u6c89\u9ed8akr1c3\u7684\u7ec6\u80de\u4e2dFe2+\u548c\u8102\u8d28\u8fc7\u6c27\u5316\u7269\u7684\u8367\u5149\u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff0c\u800c\u8fc7\u8868\u8fbeakr1c3\u7684\u7ec6\u80de\u4e2dFe2+\u548c\u8102\u8d28\u8fc7\u6c27\u5316\u7269\u7684\u8367\u5149\u6c34\u5e73\u663e\u8457\u964d\u4f4e\u3002\u8fd9\u8868\u660e\u9ad8AKR1C3\u8868\u8fbe\u6c34\u5e73\u80fd\u6709\u6548\u964d\u4f4e\u80de\u8d28\u5185Fe2+\u548c\u8102\u8d28\u8fc7\u6c27\u5316\u7269\u6c34\u5e73\uff0c\u4ece\u800c\u63d0\u793a\u8fc7\u8868\u8fbeAKR1C3\u53ef\u6291\u5236\u94c1\u6b7b\u4ea1\u3002\u94c1\u6b7b\u4ea1\u8bf1\u5bfc\u5242\uff08erastin\uff09\u663e\u8457\u589e\u52a0BEAS-2B\u7ec6\u80de\u4e2d\u4e9a\u94c1\u79bb\u5b50\u548c\u8102\u8d28\u8fc7\u6c27\u5316\u7269\u7684\u6c34\u5e73\u3002\u540c\u65f6\uff0c\u52a0\u5165erastin\u540e\uff0c\u8fc7\u8868\u8fbeAKR1C3\u7684\u7ec6\u80de\u6570\u91cf\u663e\u8457\u589e\u52a0\u3002\u7136\u800c\uff0c\u5728AKR1C3\u4f4e\u8868\u8fbe\u7684\u7ec6\u80de\u4e2d\uff0cerastin\u5e76\u6ca1\u6709\u8d77\u5230\u7c7b\u4f3c\u7684\u4f5c\u7528\uff0c\u53cd\u800c\u663e\u8457\u6291\u5236\u4e86AKR1C3\u6c89\u9ed8\u5f15\u8d77\u7684Fe2+\u548c\u8102\u8d28\u8fc7\u6c27\u5316\u7269\u7684\u589e\u52a0(\u56fe3 – d)\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009042\" data-ratio=\"0.3055555555555556\" data-type=\"png\" data-w=\"1080\" height=\"169 .34002685546875\" width=\"553 .5400390625\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_wUVUTSylo8Thic3VWNAG66AvaqfCqg-3.png?resize=553%2C169\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LSQ1wtQyiaX6kzvJuBdxkmwfFzrKKmEm9TMxWPmfh9z2BQicBWwUVUTSylo8Thic3VWNAG66AvaqfCqg\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009046\" data-ratio=\"0.6185185185185185\" data-type=\"png\" data-w=\"1080\" height=\"342 .27001953125\" width=\"553 .2100219726562\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_WleKHbrE3ibItuymOyFv8HoCiaz1eQ-3.png?resize=553%2C342\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LSQ1wtQyiaX6kzvJuBdxkmwfNlib4wxWiaibtbsoFGBlt3AYLN8R4WleKHbrE3ibItuymOyFv8HoCiaz1eQ\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009044\" data-ratio=\"0.3712962962962963\" data-type=\"png\" data-w=\"1080\" height=\"199 .54000854492188\" width=\"553 .3400268554688\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_CqWkZnUWqPOSZwmVgUcBTMnMtSFrbQ-3.png?resize=553%2C199\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LSQ1wtQyiaX6kzvJuBdxkmwfXbyJX9G1aHK5BSJvxZb83btwCqWkZnUWqPOSZwmVgUcBTMnMtSFrbQ\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><span style=\"font-size: 16px;\">    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;\">\u56fe 3 AKR1C3\u7684\u8868\u8fbe\u53ef\u4fdd\u62a4BEAS-2B<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;\">\u7ec6\u80de\u514d\u4e8e\u94c1\u6b7b\u4ea1\u6570\u636e\u56fe<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);\">4.RARRES2\u6539\u53d8MDAMB231\u7ec6\u80de\u7684\u8102\u8d28\u4ee3\u8c22<\/span><br \/><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u91c7\u7528CCK-8\u6cd5\u68c0\u6d4bAKR1C3\u8868\u8fbe\u6c34\u5e73\u7ec6\u80de\u7684\u6d3b\u6027\u3002\u6570\u636e\u663e\u793a\uff0cAKR1C3\u6c89\u9ed8\u7684\u7ec6\u80de\u6d3b\u529b\u663e\u8457\u964d\u4f4e\uff0c\u800c\u8fc7\u8868\u8fbeAKR1C3\u7684\u7ec6\u80de\u7ec6\u80de\u6d3b\u529b\u589e\u52a0\uff0c\u8bf4\u660eAKR1C3\u7684\u8868\u8fbe\u53ef\u4ee5\u663e\u8457\u5f71\u54cd\u7ec6\u80de\u6d3b\u529b\uff08\u56fe4a\uff09\u3002GSH\u53c2\u4e0e\u4e86\u751f\u7269\u8fc7\u7a0b\uff0c\u5982\u6297\u6c27\u5316\u5242\u548c\u94c1\u6b7b\u4ea1\uff0c\u5e76\u88ab\u7528\u4f5cGPX4\u7684\u5e95\u7269\u3002\u603bGSH\u5305\u62ec\u964d\u4f4e\u7684GSH\u548cGSSG\uff0c\u5b83\u4eec\u662f\u76f8\u4e92\u8f6c\u6362\u7684\uff0cGSH\/GSSG\u6bd4\u503c\u901a\u5e38\u88ab\u8ba4\u4e3a\u662f\u6c27\u5316\u5e94\u6fc0\u7684\u91cd\u8981\u6307\u6807\u3002\u672c\u7bc7\u6587\u7ae0\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u6572\u964dAKR1C3\u53ef\u4ee5\u663e\u8457\u4e0b\u8c03GSH\uff0c\u800c\u8fc7\u8868\u8fbeAKR1C3\u53ef\u4ee5\u4e0a\u8c03GSH\u3002\u6b64\u5916\uff0c\u8fc7\u8868\u8fbeAKR1C3\u5e76\u6ca1\u6709\u663e\u8457\u6539\u53d8GSSG\u7684\u542b\u91cf\uff0c\u4f46\u6572\u964dAKR1C3\u5219\u4f1a\u964d\u4f4eGSSG\u7684\u542b\u91cf\u3002GSH\/GSSG\u6bd4\u503c\u662f\u4ee3\u8868\u6c27\u5316\u5e94\u6fc0\u8fc7\u7a0b\u7684\u91cd\u8981\u94c1\u6b7b\u4ea1\u4e2d\u95f4\u4f53\uff0c\u5728AKR1C3\u7684\u6291\u5236\u4e0b\u53ef\u663e\u8457\u964d\u4f4e\uff0c\u5f53\u8fc7\u8868\u8fbeAKR1C3\u65f6\uff0cGSH\/GSSG\u6bd4\u503c\u53ef\u4e0a\u8c03\uff08\u56fe4b\uff09\u3002\u6b64\u5916\uff0c\u672c\u7bc7\u6587\u7ae0\u8fd8\u7814\u7a76\u4e86\u8fc7\u8868\u8fbeAKR1C3\u7684\u8868\u8fbe\u662f\u5426\u663e\u8457\u964d\u4f4e\u4e86ROS\u7684\u4ea7\u751f\uff0c\u4ee5\u53caAKR1C3\u7684\u4e0b\u8c03\u662f\u5426\u8bf1\u5bfc\u4e86ROS\u7684\u4ea7\u751f\uff08\u56fe4c\uff09\u3002\u5728\u94c1\u6b7b\u4ea1\u8fc7\u7a0b\u4e2d\uff0c\u52a0\u5165erastin\u663e\u8457\u4e0b\u8c03AKR1C3\uff08\u56fe4d\uff09\u3002\u6211\u4eec\u901a\u8fc7qRT-PCR\u548c\u86cb\u767d\u5370\u8ff9\u6cd5\u68c0\u6d4b\u4e86AKR1C3\u4e0d\u540c\u8868\u8fbe\u6c34\u5e73\u4e0b\u7684\u51e0\u4e2a\u5173\u952e\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\u3002ACSL4\u4fc3\u8fdb\u94c1\u6b7b\u4ea1\uff0c\u800cSLC7A11\u548cGPX4\u5bf9\u94c1\u6b7b\u4ea1\u6709\u6291\u5236\u4f5c\u7528\u3002\u6570\u636e\u663e\u793a\u5728\u57fa\u56e0\u548c\u86cb\u767d\u6c34\u5e73\u4e0a\uff0c\u6572\u964dAKR1C3\u589e\u52a0\u4e86ACSL4\uff0c\u964d\u4f4e\u4e86SLC7A11\u7684\u8868\u8fbe\uff0c\u800c\u8fc7\u8868\u8fbeAKR1C3\u5219\u4ea7\u751f\u4e86\u76f8\u53cd\u7684\u6548\u679c\u3002\u8fd9\u8868\u660eAKR1C3\u7684\u9ad8\u8868\u8fbe\u53ef\u80fd\u901a\u8fc7\u5f71\u54cdACSL4\u548cSLC7A11\u901a\u8def\u6765\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u94c1\u6b7b\u4ea1\u7684\u4fb5\u88ad\u3002AKR1C3\u7684\u6572\u964d\u548c\u8fc7\u8868\u8fbe\u90fd\u589e\u52a0\u4e86\u5173\u952e\u56e0\u5b50GPX4\u7684\u8868\u8fbe\u3002\u8fdb\u4e00\u6b65\u5206\u6790\u53d1\u73b0\uff0cAKR1C3\u8fc7\u8868\u8fbe\u663e\u8457\u6291\u5236\u4e86erastin \u8bf1\u5bfc\u7684GPX4\u4e0b\u8c03\uff08\u56fe4e\uff09\u3002   <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009045\" data-ratio=\"0.5425925925925926\" data-type=\"png\" data-w=\"1080\" height=\"300 .5400390625\" width=\"553 .6799926757812\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_h5iayy23OKcPQgk3We1eMU8GvaAVTA-3.png?resize=553%2C300\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LSQ1wtQyiaX6kzvJuBdxkmwfDFRjCKIX9gSMPZ1tDNrF1Y4QTh5iayy23OKcPQgk3We1eMU8GvaAVTA\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009047\" data-ratio=\"0.5787037037037037\" data-type=\"png\" data-w=\"1080\" height=\"309 .94000244140625\" width=\"553 .2100219726562\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_c7dUqeTic2ZucTUibrFtojNwmLBrYw-3.png?resize=553%2C309\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LSQ1wtQyiaX6kzvJuBdxkmwfqsDjDO66knfTCicTDjC81MC8jccc7dUqeTic2ZucTUibrFtojNwmLBrYw\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><span style=\"font-size: 16px;\">    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;\">\u56fe 4 AKR1C3\u5bf9BEAS-2B\u7ec6\u80de\u94c1\u6b7b\u4ea1\u7684\u4f5c\u7528<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"color: rgb(0, 82, 255);\"><strong><span style=\"color: rgb(0, 82, 255);font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;font-size: 18px;\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/strong><\/span><br \/><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u672c\u6587\u7814\u7a76\u8868\u660eAKR1C3\u5728\u54ee\u5598\uff0c\u7279\u522b\u662fMA\u4e2d\uff0c\u5177\u6709\u5f88\u9ad8\u7684\u8bca\u65ad\u548c\u9884\u540e\u4ef7\u503c\u3002\u901a\u8fc7\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u8fc7\u8868\u8fbeAKR1C3\u53ef\u4ee5\u4fdd\u62a4BEAS-2B\u7ec6\u80de\u514d\u53d7\u94c1\u6b7b\u4ea1\u7684\u4fb5\u88ad\u3002\u56e0\u6b64\uff0cAKR1C3\u53ef\u80fd\u662f\u4e00\u79cd\u5f88\u6709\u524d\u9014\u7684\u9884\u9632\u54ee\u5598\u94c1\u6b7b\u4ea1\u7684\u751f\u7269\u6807\u5fd7\u7269\u548c\u836f\u7269\u9776\u70b9\u3002<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u672c\u7bc7\u6587\u7ae0\u6570\u636e\u5728\u7ed3\u5408\u516c\u5171\u6570\u636e\u5206\u6790\u7684\u57fa\u7840\u4e0a\uff0c\u8fd8\u8fdb\u884c\u4e86\u57fa\u7840\u5b9e\u9a8c\u63a2\u7a76\u5176\u53d1\u751f\u4f5c\u7528\u7684\u5177\u4f53\u673a\u5236\uff0c\u4f7f\u6587\u7ae0\u5185\u5bb9\u66f4\u52a0\u5145\u5b9e\uff0c\u66f4\u5177\u6709\u4e34\u5e8a\u7814\u7a76\u4e0e\u5e94\u7528\u4ef7\u503c\u3002\u8fd1\u5e74\u6765\uff0c\u94c1\u6b7b\u4ea1\u8fd9\u4e00\u70ed\u70b9\u7684\u7814\u7a76\u4ecd\u7136\u8fdb\u884c\u7740\uff0c\u975e\u80bf\u7624\u75be\u75c5\u7684\u94c1\u6b7b\u4ea1\u65b9\u5411\u7814\u7a76\u4e5f\u4e0d\u65ad\u53d1\u5c55\u3002\u5982\u4f55\u8ba9\u81ea\u5df1\u7684\u6587\u7ae0\u66f4\u6709\u65b0\u610f\u662f\u4e3a\u6587\u7ae0\u589e\u8272\u7684\u91cd\u8981\u4e00\u73af\uff0c\u591a\u7ec4\u5b66\u4ee5\u53ca\u591a\u70ed\u70b9\u7684\u8054\u5408\u5206\u6790\u53ef\u4ee5\u5e2e\u52a9\u5927\u5bb6\u62d3\u5c55\u601d\u8def\uff01\u5feb\u5b66\u8d77\u6765\u53ed\uff01\uff01\uff01<\/span><\/p>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016833\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_B2jkicacLzPjw4xMSqVvoucZjonVDA-11.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'&from=appmsg\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016835\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_7TvAyUibd1TPhJmZfialJtv6tu2SEg-6.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100016834\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/14_9N02aBaau07RufXeXRLmvAHsrFZxtw-6.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;text-wrap: wrap;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;margin-bottom: 0px;\"><span style=\"font-size: var(--articleFontsize);letter-spacing: 0.034em;text-align: justify;\">   <\/span><br \/><\/p>\n<p style=\"display: none;margin-bottom: 24px;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6e29\u5dde\u533b\u79d1\u5927\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662\u5f20\u7ef4\u6eaa\u7b49\u56e2\u961f1\u533a7\u5206+\u6587\u7ae0\uff01\u94c1\u6b7b\u4ea1+\u591a\u7ec4\u5b66\u5206\u6790+\u5e72\u6e7f\u7ed3\u5408\uff0c\u975e\u80bf\u7624\u75be\u75c5\u4e5f\u540c\u6837\u7ed9\u529b\uff01 \u5c0f\u9014& […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/50012"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=50012"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/50012\/revisions"}],"predecessor-version":[{"id":50056,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/50012\/revisions\/50056"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=50012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=50012"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=50012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}