{"id":50249,"date":"2024-06-16T09:50:13","date_gmt":"2024-06-16T01:50:13","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=50249"},"modified":"2024-06-16T09:50:13","modified_gmt":"2024-06-16T01:50:13","slug":"%e7%a9%ba%e9%97%b4%e8%bd%ac%e5%bd%95%e7%bb%84%e6%95%b0%e6%8d%ae%e6%8c%96%e6%8e%98%ef%bc%9f%e5%81%9a%e7%ac%ac%e4%b8%80%e4%b8%aa%e5%90%83%e8%9e%83%e8%9f%b9%e7%9a%84%e4%ba%ba%ef%bc%81%e5%8d%97%e4%ba%ac-2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=50249","title":{"rendered":"\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01"},"content":{"rendered":"


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normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-stretch: normal;font-size: 7pt;line-height: normal;\"><\/span><\/span><span style=\"font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u73b0\u5728\u7684\u6570\u636e\u6316\u6398\u5927\u591a\u6570\u8fd8\u505c\u7559\u5728RNA-seq\u4e0a\uff0c<\/span><span style=\"font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6280\u672f\u66f4\u52a0\u8fdb\u6b65\uff0c\u5728\u63d0\u4f9b\u5355\u7ec6\u80de\u57fa\u56e0\u8868\u8fbe\u7684\u57fa\u7840\u4e0a\uff0c\u8fd8\u5177\u6709\u7ec6\u80de\u7a7a\u95f4\u5b9a\u4f4d\u7684\u80fd\u529b\uff0c<\/span><span style=\"font-family: "Times New Roman";font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u5bf9\u4e8e\u63a2\u7a76\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u5173\u7cfb\u610f\u4e49\u91cd\u5927<\/span><\/span><span style=\"font-family: "Times New Roman";font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;\"><\/span><span style=\"font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u3002\u4ece\u516c\u5171\u6570\u636e\u5e93\u540c\u65f6\u6316\u6398\u5355\u7ec6\u80de\u548c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u7684\u6587\u7ae0\u8fd8\u6bd4\u8f83\u5c11\uff0c\u53cc\u91cd\u70ed\u70b9buff\u76f8\u5f53\u7ed9\u529b<\/span><span style=\"font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u3002\u4f5c\u8005\u4eceGEO\u4e0b\u8f7d\u4e86EC\u7684\u5355\u7ec6\u80deRNA-seq\uff08scRNA-seq\uff09\u548c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\uff08ST\uff09\u6570\u636e\u96c6\uff0c\u4eceTCGA\u4e0b\u8f7d\u4e86TCGA-UCEC\u9879\u76ee\u7684RNA-Seq\uff08FPKM\uff09\u548c\u4e34\u5e8a\u6570\u636e\uff0c\u5206\u6790EC\u7684\u7ec6\u80de\u7fa4\u4f53\uff1b\u6587\u7ae0\u8fd8\u7528ST\u6570\u636e\u5206\u6790\u4e86\u7a7a\u95f4\u90bb\u5c45\u4e4b\u95f4\u7684\u901a\u4fe1\uff0c<\/span><span style=\"font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u5e76\u8bc1\u5b9e\u4e86MDL-NCL\u5728\u7ec6\u80de\u95f4\u901a\u4fe1\u4e2d\u7684\u53d1\u73b0\u3002<\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family: "Times New Roman";font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: windowtext;\">2.<span style=\"font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-stretch: normal;font-size: 7pt;line-height: normal;\"><\/span><\/span><span style=\"font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u5355\u7ec6\u80de\u548c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6574\u5408\u5206\u6790\uff0c\u4e0d\u4ec5\u521b\u65b0\u6027\u9ad8\uff0c\u800c\u4e14\u90fd\u662f<\/span><span style=\"font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(0, 0, 255);font-weight: bold;\">\u4eceGEO\u548cTCGA\u4e2d\u83b7\u53d6\u7684\u6570\u636e\uff0c\u4e0d\u7528\u62c5\u5fc3\u6837\u672c\u548c\u6d4b\u5e8f\uff0c0\u5b9e\u9a8c\u6210\u672c\u8f7b\u8f7b\u677e\u677e\u5c31\u5f97\u5230\u4e86\u7ed3\u679c<\/span><span style=\"font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\uff0c\u76f4\u63a5\u62ff\u4e0bQ1\u671f\u520a\uff01\uff0c\u8fd9\u4e48\u7b80\u5355\u7684\u53ef\u590d\u5236\u601d\u8def\u5feb\u884c\u52a8\u8d77\u6765\uff01\u522b\u53ea\u4f1a\u773c\u5df4\u5df4\u7684\u770b\u522b\u4eba\u53d1\u9ad8\u5206\u6587\u7ae0\u5566<\/span><span style=\"font-family: "Times New Roman";font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(255, 0, 0);font-weight: bold;\">(ps\uff1a\u4e0d\u77e5\u9053\u600e\u4e48\u521b\u65b0\u7684\u5c0f\u4f19\u4f34\u53ef\u4ee5\u6765\u627e\u8def\u535a\uff01\u8fd9\u91cc\u6709\u65b0\u9c9c\u51fa\u7089\u7684\u751f\u4fe1\u70ed\u70b9\u65b9\u5411\uff0c\u8fd8\u6709\u4e00\u5927\u6ce2\u7684\u53ef\u590d\u73b0\u7684\u521b\u65b0\u601d\u8def\uff0c\u611f\u5174\u8da3\u7684\u76f4\u63a5\u6765\u516c\u4f17\u53f7\u540e\u53f0\u627e\u6211\u5662\uff01)\u3002<\/span><span style=\"font-family: "Times New Roman";font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;\">    <\/span><\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016998\" data-ratio=\"1\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 212px;height: auto !important;\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-03-10_\u300c\u8f6c\u300d\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'\" \/><\/p>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;line-height: 120%;font-size: 12pt;font-family: "Times New Roman";font-weight: normal;margin-left: 42pt;text-indent: 0em;\"><o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009564\" data-ratio=\"0.49710312862108924\" data-type=\"png\" data-w=\"863\" height=\"275.2699890136719\" width=\"553.739990234375\" style=\"height: auto !important;\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-03-10_\u300c\u8f6c\u300d\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01\/3_vKABpKJnibiaDF7aYwBvt1ibKUYc9g.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRic8VATOabquZIeDPuiaZaF8mVEeNicCM17RsfMRsDOkpQeB6693vKABpKJnibiaDF7aYwBvt1ibKUYc9g\/640?wx_fmt=png'\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u9898\u76ee\uff1a\u6574\u5408\u5355\u7ec6\u80de RNA-seq \u548c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u63ed\u793a\u5b50\u5bab\u5185\u819c\u764c\u4e2d MDK-NCL \u4f9d\u8d56\u7684\u514d\u75ab\u6291\u5236\u73af\u5883<\/span><span style=\"font-size:14.0pt;line-height:120%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u6742\u5fd7\uff1aFrontiers in Immunology<\/span><span style=\"font-size:14.0pt;line-height:120%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=7.3<\/span><span style=\"font-size:14.0pt;line-height:120%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e744\u6708<\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\"><span style=\"outline: 0px;color: rgb(0, 0, 0);text-wrap: wrap;font-family: system-ui, -apple-system, "system-ui", "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;font-size: 16px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><span style=\"outline: 0px;letter-spacing: 0.544px;\"><span style=\"outline: 0px;color: rgb(0, 82, 255);\"><strong style=\"outline: 0px;\"><\/strong><\/span><\/span><\/span><\/span><\/section>\n<section style=\"text-align: center;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"color: rgb(0, 82, 255);\"><strong><span style=\"color: rgb(0, 82, 255);font-family: \u7b49\u7ebf;font-size: 14pt;font-weight: bold;text-align: center;text-indent: 0em;letter-spacing: 0.034em;\">\u7814\u7a76\u80cc\u666f<\/span><\/strong><\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u80bf\u7624\u5177\u6709\u5e7f\u6cdb\u7684\u5f02\u8d28\u6027\uff0c\u5bf9\u80bf\u7624\u7684\u8fdb\u5c55\u548c\u6cbb\u7597\u53cd\u5e94\u81f3\u5173\u91cd\u8981\u3002\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7531\u4e0d\u540c\u529f\u80fd\u8868\u578b\u548c\u7a7a\u95f4\u5206\u5e03\u6a21\u5f0f\u7684\u6076\u6027\u7ec6\u80de\u548c\u57fa\u8d28\u7ec6\u80de\u7ec4\u6210\uff0c\u5448\u73b0\u51fa\u9057\u4f20\u591a\u6837\u6027\u548c\u514b\u9686\u9009\u62e9\u5bfc\u81f4\u7684\u5f02\u8d28\u6027\u3002\u5b50\u5bab\u5185\u819c\u764c\uff08EC\uff09\u662f\u53d1\u8fbe\u56fd\u5bb6\u6700\u5e38\u89c1\u7684\u5973\u6027\u751f\u6b96\u7cfb\u7edf\u6076\u6027\u80bf\u7624\uff0c\u5305\u62ec\u4e0d\u540c\u7c7b\u578b\uff0c\u5177\u6709\u4e0d\u540c\u7684\u5371\u9669\u56e0\u7d20\u3001\u9884\u540e\u548c\u8f6c\u79fb\u6a21\u5f0f\u3002\u80bf\u7624\u5f02\u8d28\u6027\u53ef\u80fd\u5bf9\u8bca\u65ad\u3001\u9884\u540e\u548c\u6cbb\u7597\u51b3\u7b56\u4ea7\u751f\u91cd\u8981\u5f71\u54cd\u3002ScRNA-seq\u6280\u672f\u53ef\u4ee5\u63ed\u793a\u7ec6\u80de\u6c34\u5e73\u7684\u5f02\u8d28\u6027\uff0c\u4e3a\u63a2\u7d22EC\u7684TME\u63d0\u4f9b\u4e86\u65b0\u9014\u5f84\u3002\u7814\u7a76\u8005\u4f7f\u7528GEO\u7684scRNA-seq\u6570\u636e\u7814\u7a76\u4e86EC\uff0c\u5e76\u6574\u5408\u4e86scRNA-seq\u548c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\uff08ST\uff09\u6765\u63ed\u793aEC\u7684\u7ec4\u7ec7\u7ed3\u6784\u3002<\/span>    <span style=\"font-family: "Times New Roman";font-size: 14pt;font-weight: bold;text-align: center;text-indent: 0em;letter-spacing: 0.034em;\">         <\/span><o:p style=\"font-family: "Times New Roman";font-size: 14pt;font-weight: bold;text-align: center;text-indent: 0em;letter-spacing: 0.034em;\"> <\/o:p><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><strong><span style=\"font-size: 14pt;line-height: 120%;font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);\">\u6570\u636e\u6765\u6e90<\/span><\/strong><\/section>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" style=\"margin-left: 0px;border-width: initial;border-style: none;border-color: initial;border-collapse: collapse;width: 100%;\">\n<tbody>\n<tr>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;background:#4472C4;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u6570\u636e\u96c6\/\u961f\u5217<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:normal;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;background:#4472C4;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:none;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u6570\u636e\u5e93<\/span><span style=\"font-size:14.0pt;line-height:120%;mso-bidi-font-size:12.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:normal;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;background:#4472C4;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:none;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u6570\u636e\u7c7b\u578b<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:normal;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;background:#4472C4;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:none;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">\u8be6\u7ec6\u4fe1\u606f<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:normal;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;background:#D9E2F3;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:normal;mso-bidi-font-weight:normal;\">GSE173682<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;background:#D9E2F3;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;background:#D9E2F3;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">scRNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;background:#D9E2F3;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">5\u4f8b<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">EC<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:normal;mso-bidi-font-weight:normal;\">GSM6177623<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">GEO<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">ST\u6570\u636e<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">1\u4f8b<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">EC<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;background:#D9E2F3;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:normal;mso-bidi-font-weight:normal;\">GSE120490<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;background:#D9E2F3;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">GEO<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;background:#D9E2F3;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">RNA-seq\u6570\u636e<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;background:#D9E2F3;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">145\u4f8b<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">EC<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:normal;mso-bidi-font-weight:normal;\">TCGA-UCEC<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">TCGA<\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">RNA-seq\u6570\u636e<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<\/td>\n<td width=\"138\" valign=\"middle\" style=\"width:103.7pt;border-top:solid #8EAADB 1.0pt;mso-border-top-alt:solid #8EAADB 0.5pt;border-left:solid #8EAADB 1.0pt;mso-border-left-alt:solid #8EAADB 0.5pt;border-bottom:solid #8EAADB 1.0pt;mso-border-bottom-alt:solid #8EAADB 0.5pt;border-right:solid #8EAADB 1.0pt;mso-border-right-alt:solid #8EAADB 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">EC:553<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4f8b,<\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">\u6b63\u5e38\uff1a35<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4f8b<\/span><\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-size:14.0pt;line-height:120%;mso-bidi-font-size:12.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"color: rgb(0, 82, 255);\"><strong><span style=\"color: rgb(0, 82, 255);font-size: 14pt;line-height: 120%;font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-weight: bold;\">\u7814\u7a76\u601d\u8def<\/span><\/strong><\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: left;text-indent: 0em;margin-bottom: 24px;\"><span style=\"mso-bidi-font-size:12.0pt;font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u672c\u6587\u7ae0\u7684\u7814\u7a76\u805a\u7126\u5b50\u5bab\u5185\u819c\u764c\uff08EC\uff09\u7684\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\uff0c\u901a\u8fc7\u6574\u5408\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u548c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\uff08ST\uff09\u6765\u8bc4\u4f30EC\u7684TME\u4e2d\u7684\u7ec6\u80de\u7fa4\u4f53\u3002\u4f5c\u8005\u4eceGEO\u4e0b\u8f7d\u4e86EC\u7684scRNA-seq\u548cST\u6570\u636e\u96c6\uff0c\u5e76\u4f7f\u7528R\u8f6f\u4ef6\u8fdb\u884c\u6570\u636e\u5206\u6790\uff0c\u5177\u4f53\u4f7f\u7528\u8f6f\u4ef6\u5305\u5305\u62ecSeurat\u3001SingleR\u3001GSVA\u3001clusterProfiler\u3001CellChat\u548cmsigdbr\u7b49\u3002\u4f5c\u8005\u4fdd\u755933,162\u4e2a\u7ec6\u80de\u548c33,408\u4e2a\u57fa\u56e0\u8fdb\u884c\u8fdb\u4e00\u6b65\u5206\u6790\uff0c\u5e76\u5c06\u7ec6\u80de\u5206\u7c7b\u4e3a9\u4e2a\u7c07\u3002\u57fa\u56e0\u7ec4\u53d8\u5f02\u5206\u6790\u4f7f\u7528msigdbr\u8f6f\u4ef6\u5305\uff0c\u63ed\u793a\u4e86\u4e0a\u76ae\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\u7684\u4e9a\u7c07\u4e2d\u5bcc\u96c6\u7684\u901a\u8def\u663e\u8457\u4e0d\u540c\uff0c\u8fd9\u8868\u660eEC\u7684\u5f02\u8d28\u6027\u8f83\u5927\u3002\u8fdb\u4e00\u6b65\u5206\u6790\u53d1\u73b0\uff0c\u4e0a\u76ae\u7ec6\u80de1\u548c2\u7684\u4e9a\u7c07\u8868\u73b0\u51fa\u66f4\u6076\u6027\u7684\u8868\u578b\uff0c\u8fd9\u53ef\u80fd\u901a\u8fc7MDL-NCL\u4fe1\u53f7\u901a\u8fc7MK\u901a\u8def\u8d4b\u4e88\u5185\u76ae\u7ec6\u80de0\u7684\u4e9a\u7c07\u6076\u6027\u8868\u578b\u3002\u4f5c\u8005\u8fd8\u7528ST\u6570\u636e\u5206\u6790\u4e86\u7a7a\u95f4\u90bb\u5c45\u4e4b\u95f4\u7684\u901a\u4fe1\uff0c\u5e76\u8bc1\u5b9e\u4e86MDL-NCL\u5728\u7ec6\u80de\u95f4\u901a\u4fe1\u4e2d\u7684\u53d1\u73b0\u3002TCGA\u548cGEO\u5206\u6790\u8868\u660e\uff0cNCL\u7684\u8868\u8fbe\u6c34\u5e73\u4e0eImmuneScore\u5448\u8d1f\u76f8\u5173\u3002<span style=\"mso-spacerun:yes;\">   <\/span><\/span>    <span style=\"font-family: "Times New Roman";font-size: 14pt;font-weight: bold;text-align: center;text-indent: 0em;letter-spacing: 0.034em;\">         <\/span><o:p style=\"font-family: "Times New Roman";font-size: 14pt;font-weight: bold;text-align: center;text-indent: 0em;letter-spacing: 0.034em;\"> <\/o:p><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-size:14.0pt;line-height:120%;mso-bidi-font-size:12.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><strong><span style=\"font-size: 14pt;line-height: 120%;font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);\">\u4e3b\u8981\u7ed3\u679c<\/span><\/strong><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: left;text-indent: 0em;margin-bottom: 24px;\"><span style=\"background-color: rgb(61, 170, 214);font-family: "Times New Roman";font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;color: rgb(255, 255, 255);\">1.EC\u7684scRNA-seq\u548c\u7ec6\u80de\u5206\u578b<\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u63a5\u53d7scRNA-seq\u68c0\u67e5\u76845\u4e2a\u7ec4\u7ec7\u5747\u6765\u81ea\u5b50\u5bab\u5185\u819c\u6837\u764c\u60a3\u8005\u3002\u7ecf\u8fc7\u9ad8\u8d28\u91cf\u8fc7\u6ee4\u540e\uff0c\u572833,162\u4e2a\u7ec6\u80de\u4e2d\u603b\u5171\u68c0\u6d4b\u523020\u4ebf\u4e2aUMI\u548c33,408\u4e2a\u57fa\u56e0\uff08\u56fe1A\uff09\u3002\u4f7f\u7528 CCA \u6821\u6b63\u4e86\u6279\u6b21\u6548\u5e94\uff0c\u5c06\u5f97\u5230\u7684<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">9\u4e2a\u7c07<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u5206\u914d\u5230\u5df2\u77e5\u7684\u7ec6\u80de\u8c31\u7cfb\uff0c<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u5305\u62ec\u6210\u7ea4\u7ef4\u7ec6\u80de\u3001\u4e0a\u76ae\u7ec6\u80de\u3001\u5185\u76ae\u7ec6\u80de\u3001T\u7ec6\u80de\u3001NK\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u3001\u7ea4\u6bdb\u7ec6\u80de\u3001\u80a5\u5927\u7ec6\u80de\u548cB\u7ec6\u80de<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\uff08\u56fe1A)\u3002\u56fe1B\u663e\u793a\u6bcf\u79cd\u7ec6\u80de\u7c7b\u578b\u4ee3\u8868\u6027\u6807\u8bb0\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u6839\u636eMUC16\/CA125\u7684\u8868\u8fbe\uff0cEC\u7ec6\u80de\u6765\u6e90\u4e8e\u4e0a\u76ae\u7ec6\u80de\u548c\u7ea4\u6bdb\u7ec6\u80de\uff0c\u764c\u7ec6\u80de\u7684\u8f6c\u5f55\u672c\u6bd4\u5176\u4ed6\u7ec6\u80de\u591a\uff08\u56fe 1A\u3001C\uff09\u3002<\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009567\" data-ratio=\"1.0240096038415367\" data-type=\"png\" data-w=\"833\" height=\"514.4099731445312\" width=\"502.34002685546875\" style=\"height: auto !important;\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-03-10_\u300c\u8f6c\u300d\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01\/4_zlAupwQqEHZZCWTDt6JyKUo5se8oXQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRic8VATOabquZIeDPuiaZaF8vemt4kjHavsVBu8RTGoha3kVzlAupwQqEHZZCWTDt6JyKUo5se8oXQ\/640?wx_fmt=png'\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 14px;\">\u56fe1\uff1a\u5b50\u5bab\u5185\u819c\u6837\u764c\u7684 33,162 \u4e2a\u5355\u7ec6\u80de\u6982\u8ff0<\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: left;text-indent: 0em;margin-bottom: 24px;\"><span style=\"background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);\"><span style=\"color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);font-family: "Times New Roman";font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">2.<\/span><span style=\"color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u5185\u76ae\u7ec6\u80de\u4e9a\u7c07<\/span><span style=\"color: rgb(255, 255, 255);font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;background-color: rgb(61, 170, 214);font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u7684\u9274\u5b9a\u53ca\u57fa\u56e0\u8868\u8fbe\u5206\u6790<\/span><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;line-height: 120%;font-size: 12pt;font-family: "Times New Roman";font-weight: normal;margin-left: 18pt;text-indent: 0em;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u603b\u5171\u68c0\u6d4b\u52303,736\u4e2a\u5185\u76ae\u7ec6\u80de\u5e76\u91cd\u65b0\u805a\u7c7b\u62103\u4e2a\u7c07\uff08\u56fe2A)\u3002\u7c070\u548c1\u88ab\u9274\u5b9a\u4e3a\u8840\u6db2\u5185\u76ae\u7ec6\u80de\uff0c\u7c072\u88ab\u9274\u5b9a\u4e3a\u6dcb\u5df4\u5185\u76ae\u7ec6\u80de\uff08\u56fe2B)\u3002\u8fdb\u4e00\u6b65\u7684\u5206\u6790\u8868\u660e\uff0c\u4e0e\u8840\u7ba1\u751f\u6210\u76f8\u5173\u7684\u9009\u5b9a\u57fa\u56e0\u5728\u7c070\u548c1\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff08\u56fe2C)\u3002\u901a\u8def\u5206\u6790\u663e\u793a\uff0c3\u4e2a\u805a\u7c7b\u95f4\u5177\u6709\u663e\u8457\u7684\u8868\u578b\u591a\u6837\u6027\uff0c\u4e14\u805a\u7c7b0\u53c2\u4e0e\u7684\u901a\u8def\u591a\u4e8e\u5176\u4ed62\u4e2a\u901a\u8def\uff08\u56fe2D)\u3002\u5206\u6790TCGA\u4e2d\u6807\u8bb0\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u53d1\u73b0<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">0\u7c07\u7684\u6807\u8bb0\u57fa\u56e0\u5728SCC\u548cEAC\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\u9ad8\u4e8eEM\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u800c1\u548c2\u7c07\u7684\u6807\u8bb0\u57fa\u56e0\u8868\u73b0\u51fa\u76f8\u53cd\u7684\u8d8b\u52bf<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\uff08\u56fe2E)\u3002\u6807\u8bb0\u57fa\u56e0\u7684\u5b58\u6d3b\u5206\u6790\u663e\u793a\uff0cHSPA1B\u3001TFF3\u548cLAMA4\u4e0eEC\u5b58\u6d3b\u7387\u76f8\u5173\uff08\u56fe2F)\u3002<\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009565\" data-ratio=\"1.0242857142857142\" data-type=\"png\" data-w=\"700\" height=\"503.1400146484375\" width=\"491.2099609375\" style=\"height: auto !important;\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-03-10_\u300c\u8f6c\u300d\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01\/5_pgicibrFlAaMVM713yl7SYjdWs4WIA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRic8VATOabquZIeDPuiaZaF8jslnicdfqvudo34zjU35RThFOUUpgicibrFlAaMVM713yl7SYjdWs4WIA\/640?wx_fmt=png'\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">\u56fe2\uff1a\u5185\u76ae\u7ec6\u80de\u7c07<\/span><span style=\"font-size: 14px;font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-weight: bold;\">\u7684\u9274\u5b9a\u53ca\u57fa\u56e0\u8868\u8fbe\u5206\u6790<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: left;text-indent: 0em;margin-bottom: 24px;\"><span style=\"background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);\"><span style=\"color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);font-family: "Times New Roman";font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">3.<\/span><span style=\"color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u4e0a\u76ae\u7ec6\u80de\u4e9a\u7c07\u7684\u9274\u5b9a\u53ca\u57fa\u56e0\u8868\u8fbe\u5206\u6790<\/span><\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u603b\u5171\u68c0\u6d4b\u5230 5,586 \u4e2a\u4e0a\u76ae\u7ec6\u80de\u5e76\u91cd\u65b0\u805a\u7c7b\u6210 5 \u4e2a\u7c07 \uff08\u56fe3A)\u3002\u8fd9\u4e9b\u7c07\u7684\u6807\u8bb0\u57fa\u56e0\u5217\u4e8e\u8868S6\u4e2d\uff0c\u4ee3\u8868\u6027\u6807\u8bb0\u57fa\u56e0\u663e\u793a\u5728\u56fe3B\u3002\u6bd4\u8f83\u4e86\u901a\u8def\u6d3b\u52a8\u3002<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u96c6\u7fa4 0 \u4e0e\u5176\u4ed6\u56db\u4e2a\u96c6\u7fa4\u6709\u5f88\u5927\u4e0d\u540c<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u3002\u7b2c 1 \u7ec4\u548c\u7b2c 2 \u7ec4\u4ee5\u53ca\u7b2c 3 \u7ec4\u548c\u7b2c 4 \u7ec4\u76f8\u4f3c\uff08\u56fe3C)\u3002\u6807\u8bb0\u57fa\u56e0\u5728TCGA\u4e2d\u7684\u5e73\u5747\u8868\u8fbe\u8868\u73b0\u5728\u56fe3D\u3002<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u9664\u7b2c4\u7c07\u5916\uff0c\u6240\u6709\u7c07\u7684\u6807\u8bb0\u57fa\u56e0\u5747\u663e\u793aEAC\u4e0eEM\u6216SCC\u4e0eEM\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u76f8\u5173\u6027<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u3002\u6807\u8bb0\u57fa\u56e0\u7684\u5b58\u6d3b\u5206\u6790\u663e\u793a\u5728\u56fe3E\uff0c6\u4e2a\u57fa\u56e0\u4e0eEC\u5b58\u6d3b\u7387\u76f8\u5173\uff08\u56fe3E)\u3002<\/span>    <o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009568\" data-ratio=\"0.9794801641586868\" data-type=\"png\" data-w=\"731\" height=\"560.010009765625\" width=\"571.6799926757812\" style=\"height: auto !important;\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-03-10_\u300c\u8f6c\u300d\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01\/6_pkOXLsPlwYHIGUWgGPgcmyFjAyE7hg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRic8VATOabquZIeDPuiaZaF8rsicDzp5dzCQUcnY7zvjeDVrnpkOXLsPlwYHIGUWgGPgcmyFjAyE7hg\/640?wx_fmt=png'\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 14px;\">\u56fe3\uff1a\u4e0a\u76ae\u7ec6\u80de\u7c07\u7684\u9274\u5b9a\u53ca\u57fa\u56e0\u8868\u8fbe\u5206\u6790<\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: left;text-indent: 0em;margin-bottom: 24px;\"><span style=\"background-color: rgb(61, 170, 214);font-family: "Times New Roman";font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;color: rgb(255, 255, 255);\">4.scRNA-seq\u6570\u636e\u4e2d\u7ec6\u80de\u95f4\u7684\u7ec6\u80de\u95f4\u901a\u8baf<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: "Times New Roman";font-weight: normal;text-indent: 0em;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4f7f\u7528 CellChat \u548c scRNA-seq \u6570\u636e\u5206\u6790\u4e86 9 \u4e2a\u7ec6\u80de\u7c07\u4e4b\u95f4\u7684\u901a\u4fe1\uff0c\u53d1\u73b0\u8fd9\u4e9b\u7ec6\u80de\u901a\u8fc7 27 \u6761\u901a\u8def\u76f8\u4e92\u4f5c\u7528\uff08\u56fe 4A\u3001B)\uff0c\u56fe 4A\u3001B\u6309\u5f3a\u5ea6\u6392\u5e8f\uff08\u4ece\u5de6\u5230\u53f3\uff09\uff0c\u6700\u4e0a\u9762\u7684\u4e00\u6761\u901a\u8def\u662fMK\u901a\u8def\u3002\u4e0a\u76ae\u7ec6\u80de\u53d1\u51fa\u7684\u4fe1\u53f7\u6700\u5f3a\uff08\u56fe 4A\u3001C\u3001D\uff0c S1 \uff09\uff1b\u5185\u76ae\u7ec6\u80de\u6bd4\u5176\u4ed6\u7ec6\u80de\u63a5\u6536\u5230\u66f4\u591a\u7684\u4fe1\u53f7\uff08\u56fe 4B\u3001D)\u3002<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u7ec6\u80de\u4e3b\u8981\u901a\u8fc7MK\u4fe1\u53f7\u901a\u8def\u4e2dMDK-NCL\u7684\u914d\u4f53\u53d7\u4f53\uff08L-R\uff09\u5bf9\u63a5\u89e6<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\uff08\u56fe4E\uff0cS2 \uff09\u3002MK\u4fe1\u53f7\u901a\u8def\u4e2d\u7684\u4fe1\u53f7\u663e\u793a\u5728\u56fe4F\uff0cMK\u901a\u8def\u4e2d\u914d\u4f53\u548c\u53d7\u4f53\u7684\u8868\u8fbe\u6c34\u5e73\u663e\u793a\u5728\u56fe4G.<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">Midkine\uff08MK\uff0cMDK\uff09\u4e3b\u8981\u5728\u4e0a\u76ae\u7ec6\u80de\u548c\u7ea4\u6bdb\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u6838\u4ec1\u7d20\uff08NCL\uff09\u5728\u6240\u67099\u79cd\u7ec6\u80de\u4e2d\u5747\u6709\u8868\u8fbe\u3002<\/span>   <\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: "Times New Roman";font-weight: normal;text-indent: 0em;\"> <o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009566\" data-ratio=\"1.4119496855345912\" data-type=\"png\" data-w=\"636\" height=\"650.8800048828125\" width=\"461.07000732421875\" style=\"height: auto !important;\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-03-10_\u300c\u8f6c\u300d\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01\/7_CINfpXuLWRIUBBJELbaicibnQUibbQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRic8VATOabquZIeDPuiaZaF88kmuYuySn7uRLUBuSaPDF5senl0CINfpXuLWRIUBBJELbaicibnQUibbQ\/640?wx_fmt=png'\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">\u56fe4\uff1a<\/span><span style=\"font-size: 14px;font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;color: rgb(51, 51, 51);background: rgb(255, 252, 240);\">\u7ec6\u80de\u95f4\u901a\u8baf<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: left;text-indent: 0em;margin-bottom: 24px;\"><span style=\"background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);\"><span style=\"color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);font-family: "Times New Roman";font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">5.<\/span><span style=\"color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u4e0a\u76ae\u7ec6\u80de\u4e0e\u5185\u76ae\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/span><\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u8fdb\u4e00\u6b65\u5206\u6790\u4e86\u4e0a\u76ae\u7ec6\u80de\u4e9a\u7c07\u548c\u5185\u76ae\u7ec6\u80de\u4e4b\u95f4\u7684\u901a\u8baf\u3002\u6211\u4eec\u53d1\u73b0\u4e0a\u76ae\u7ec6\u80de\u7684\u7c07 1\uff08Ep. 1\uff09\u53d1\u51fa\u7684\u4fe1\u53f7\u6700\u5f3a\uff0c\u5185\u76ae\u7ec6\u80de\u7684\u7c070\uff08En. 0\uff09\u6bd4\u5176\u4ed6\u7c07\u63a5\u6536\u5230\u66f4\u591a\u7684\u4fe1\u53f7\uff08\u56fe S3A\u2013C\uff09\u3002<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">MK\u4e5f\u662f\u53c2\u4e0e\u4e0a\u76ae\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\u4e4b\u95f4\u4ea4\u6d41\u7684\u9996\u8981\u9014\u5f84\u3002<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\">MDK \u2013 NCL \u4ecd\u7136\u662f L-R \u5bf9\u4e2d\u6392\u540d\u9760\u524d\u7684\u4e00\u5bf9\uff08\u56feS3D\uff09\u3002<\/span>    <o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009569\" data-ratio=\"0.754874651810585\" data-type=\"png\" data-w=\"718\" height=\"418.010009765625\" width=\"553.739990234375\" style=\"height: auto !important;\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-03-10_\u300c\u8f6c\u300d\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01\/8_dUkFQ0jDNSstKdHKhDbPNCOBcQes2w.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRic8VATOabquZIeDPuiaZaF8Pm1NZzRpduAoFQ27Js03YMZTdUkFQ0jDNSstKdHKhDbPNCOBcQes2w\/640?wx_fmt=png'\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-size:10.5pt;line-height:120%;mso-bidi-font-size:10.5pt;font-family:Microsoft YaHei UI;mso-ascii-font-family:Microsoft YaHei UI;font-variant:normal;text-transform:none;letter-spacing:0.4pt;background:#FFFFFF;\">\u56feS3\uff1a\u5b50\u5bab\u5185\u819c\u764c\u4e2d MDK-NCL \u4f9d\u8d56\u7684\u514d\u75ab\u6291\u5236\u73af\u5883<\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: left;text-indent: 0em;margin-bottom: 24px;\"><span style=\"background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);\"><span style=\"color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);font-family: "Times New Roman";font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">6.<\/span><span style=\"color: rgb(255, 255, 255);background-color: rgb(61, 170, 214);font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u7ec6\u80de\u751f\u6001\u4f4d\u76f8\u4e92\u4f5c\u7528<\/span><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;line-height: 120%;font-size: 12pt;font-family: "Times New Roman";font-weight: normal;margin-left: 18pt;text-indent: 0em;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4f7f\u7528\u5e26\u6709ST\u6570\u636e\u7684NICHES\u5206\u6790\u4e86\u7a7a\u95f4\u90bb\u5c45\u4e4b\u95f4\u7684\u901a\u4fe1\uff0c\u5728 1,351 \u4e2a\u70b9\u68c0\u6d4b\u5230 660 \u4e07\u4e2a UMI \u548c 33,538 \u4e2a\u57fa\u56e0\u3002\u6211\u4eec\u5206\u6790\u4e86ST\u6570\u636e\u5e76\u5c06\u5176\u4e0escRNA-seq\u6570\u636e\u96c6\u6574\u5408\uff0c\u5e76\u5c06scRNA-seq\u4e2d\u68c0\u6d4b\u5230\u76847\u79cd\u7ec6\u80de\u5b9a\u4f4d\u5230EC\u7ec4\u7ec7\u5207\u7247\uff08\u56fe 5A\u3001B)\u3002\u6211\u4eec\u4f7f\u7528\u7a7a\u95f4\u6563\u70b9\u997c\u56fe\u6765\u663e\u793a 7 \u79cd\u7ec6\u80de\u7c7b\u578b \uff08\u56fe 5A\uff09\uff0c\u4e0a\u76ae\u7ec6\u80de\u4e3a\u4e3b\u8981\u7ec6\u80de\uff0c\u4f7f\u7528NICHES\u7814\u7a76\u4e86\u7ec6\u80de\u751f\u6001\u4f4d\uff0c\u5b83\u4f30\u8ba1\u4e86ST\u6570\u636e\u4e2d\u7684\u5c40\u90e8\u5fae\u73af\u5883\u3002\u4eceUMAP\u56fe\u4e2d\u53ef\u4ee5\u770b\u51fa\u56fe5C\uff0c8\u4e2a\u7c07\u7684\u5fae\u73af\u5883\u4e4b\u95f4\u5b58\u5728\u4e00\u4e9b\u660e\u663e\u7684\u91cd\u53e0\uff0c\u8fd9\u4e9b\u91cd\u53e0\u6697\u793a\u4e86\u5b83\u4eec\u4e4b\u95f4\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\u3002\u8ba1\u7b97\u4e86\u201cNeighborhoodToCell\u201d\u6d4b\u5b9a\u4e2d\u6240L-R\u5bf9\u7684\u884c\u603b\u548c\uff0c\u7136\u540e\u5bf9\u603b\u548c\u8fdb\u884c\u9012\u51cf\u6392\u5e8f\uff0c\u524d 20\u4e2aL-R\u5bf9\u5217\u5728\u56feS4\u4e2d\u3002\u6211\u4eec\u53d1\u73b0MDK\u51fa\u73b0\u5728\u524d 20\u4e2aLR\u5bf9\u4e2d\u76845\u4e2a\u4e2d\uff0c\u5305\u62ec MDK-NCL\u3002\u6211\u4eec\u8fdb\u4e00\u6b65\u7ed8\u5236\u4e86MDK\uff0cNCL\u4ee5\u53caMDK-NCL\u4e0e\u7ec4\u7ec7\u533a\u57df\uff08\u56fe5D)\u3002<\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009570\" data-ratio=\"0.6280653950953679\" data-type=\"png\" data-w=\"734\" height=\"347.739990234375\" width=\"553.739990234375\" style=\"height: auto !important;\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-03-10_\u300c\u8f6c\u300d\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01\/9_ciaT1ePKbbChYucLqeUh4ZGk3SUiaQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRic8VATOabquZIeDPuiaZaF8uxKP6MymRicfUVVRbUMEqRGrXZHiciaT1ePKbbChYucLqeUh4ZGk3SUiaQ\/640?wx_fmt=png'\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-size:10.5pt;line-height:120%;mso-bidi-font-size:10.5pt;font-family:Microsoft YaHei UI;mso-ascii-font-family:Microsoft YaHei UI;font-variant:normal;text-transform:none;letter-spacing:0.4pt;background:#FFFFFF;\">\u56fe5\uff1a\u5b50\u5bab\u5185\u819c\u764c\u7ec4\u7ec7\u5207\u7247\u4e0a\u7684\u7ec6\u80de\u7c7b\u578b\u56fe\u8c31<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"background-color: rgb(61, 170, 214);font-family: "Times New Roman";font-size: 12pt;text-align: justify;text-indent: 0em;letter-spacing: 0.034em;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;color: rgb(255, 255, 255);\">7.MDK \u2013 NCL \u901a\u8def\u8bf1\u5bfc\u7684\u514d\u75ab\u6291\u5236\u73af\u5883<\/span><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e3a\u4e86\u63a2\u7a76MK\u901a\u8def\u5728EC\u4e2d\u7684\u4f5c\u7528\uff0c\u6211\u4eec\u5229\u7528TCGA\u7684\u6570\u636e\u5206\u6790\u4e86\u8be5\u901a\u8def\u4e2d\u914d\u4f53\u548c\u53d7\u4f53\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u6240\u6709\u914d\u4f53\u548c\u53d7\u4f53\u5728 SCC\u548cEM\u4e4b\u95f4\u6216 EAC \u548c EM \u4e4b\u95f4\u5747\u6709\u5dee\u5f02\u8868\u8fbe \uff08\u56fe6A)\u3002MDK\u5728SCC\u548cEAC\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\u9ad8\u4e8eEM\u3002NCL \u5728SCC\u548cEM\u4e4b\u95f4\u53ea\u6709\u7ec6\u5fae\u7684\u533a\u522b\u3002\u5728\u6211\u4eec\u7684\u961f\u5217\u4e2d\uff0cMDK \u548c NCL \u5728 EC \u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\u5747\u9ad8\u4e8e\u6b63\u5e38\u7ec4\u7ec7 \uff08\u56fe6B)\u3002\u6211\u4eec\u4f7f\u7528TCGA\u961f\u5217\u7684\u4f30\u8ba1\u5305\u8ba1\u7b97\u4e86ImmuneScore\u3001StromalScore\u548cESTIMATEScore\uff0c\u5e76\u8bc4\u4f30\u4e86\u5b83\u4eec\u4e0eMK\u901a\u8def\u57fa\u56e0\u7684\u5173\u7cfb\u3002\u663e\u8457\u7684\u5173\u8054\u663e\u793a\u5728\u56fe6C\uff0c\u5927\u591a\u6570\u57fa\u56e0\u4e0e\u5206\u6570\uff08\u56fe6C\uff09\u548cNCL\u4e0e\u6240\u6709\u4e09\u4e2a\u5206\u6570\uff08\u56fe 6D).\u7ecf\u8fc7\u5206\u6790GSE120490\uff0c\u6211\u4eec\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86TCGA\u6570\u636e\u96c6\u4e2d\u7684\u53d1\u73b0\uff08\u56feS5\uff09\uff0c\u56e0\u6b64EC\u7ec6\u80de\u53ef\u80fd\u901a\u8fc7MDK-NCL\u4fe1\u53f7\u4f20\u5bfc\u901a\u8fc7MK\u901a\u8def\u6291\u5236TME\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u53cd\u5e94\u3002<\/span>    <o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009571\" data-ratio=\"1.1336898395721926\" data-type=\"png\" data-w=\"748\" height=\"627.739990234375\" width=\"553.739990234375\" style=\"height: auto !important;\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-03-10_\u300c\u8f6c\u300d\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01\/10_1qIrvADeJy1bbczIkASEgsjWe0O9Mg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRic8VATOabquZIeDPuiaZaF8Ipc1Z7bibcvSe0wHYd7evhpPd1qIrvADeJy1bbczIkASEgsjWe0O9Mg\/640?wx_fmt=png'\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-size:10.5pt;line-height:120%;mso-bidi-font-size:10.5pt;font-family:Microsoft YaHei UI;mso-ascii-font-family:Microsoft YaHei UI;font-variant:normal;text-transform:none;letter-spacing:0.4pt;background:#FFFFFF;\">\u56fe6\uff1aMK\u4fe1\u53f7\u7f51\u7edc\u6d89\u53ca\u76848\u4e2a\u57fa\u56e0\u7684\u8868\u8fbe<\/span><\/section>\n<section style=\"margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 0em;margin-bottom: 24px;\"><strong><span style=\"font-size: 14pt;line-height: 120%;font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/strong><\/section>\n<section style=\"text-align: left;margin-left: 0pt;line-height: 120%;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-indent: 0em;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u8fd9\u7bc7\u6587\u7ae0\u53ef\u8c13\u662f\u7d27\u8ddf\u5f53\u524d\u7814\u7a76\u6f6e\u6d41\uff0c\u5728\u70ed\u70b9RNA-seq\u7684\u57fa\u7840\u4e0a\uff0c\u521b\u65b0\u6027\u5730\u7ed3\u5408\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6280\u672f\uff0c\u8fd9\u79cd\u8fdb\u6b65\u7684\u6280\u672f\u5bf9\u4e8e\u63a2\u7a76\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u5173\u7cfb\u610f\u4e49\u91cd\u5927\u3002\u867d\u7136\u4f5c\u8005\u4f7f\u7528\u4e86\u5355\u7ec6\u80de\u548c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\uff0c\u4f46\u90fd\u662f\u4eceGEO\u548cTCGA\u4e2d\u83b7\u53d6\u7684\u6570\u636e\uff0c\u8fd9\u5c31\u7ed9\u6211\u4eec\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5f88\u597d\u7684\u601d\u8def\uff0c\u73b0\u5728\u7684\u6570\u636e\u6316\u6398\u5927\u591a\u6570\u8fd8\u505c\u7559\u5728RNA-seq\u4e0a\uff0c\u4ece\u516c\u5171\u6570\u636e\u5e93\u6316\u6398\u5355\u7ec6\u80de\u548c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u7684\u6587\u7ae0\u8fd8\u6bd4\u8f83\u5c11\u3002<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;background:#FFFF00;mso-highlight:#FFFF00;\">\u60f3\u5728\u8fd9\u4e2a\u65b9\u5411\u505a\u70b9\u65b0\u4e1c\u897f\u7684\u5c0f\u4f19\u4f34\uff0c\u4e0d\u8981\u9519\u8fc7\u8fd9\u4e2a\u597d\u601d\u8def\uff0c\u8fd8\u5728\u89c2\u671b\u7684\u670b\u53cb\u4eec\u7559\u7ed9\u4f60\u4eec\u7684\u65f6\u95f4\u4e0d\u591a\u4e86\u54df\uff0c\u8d81\u7740\u7c7b\u4f3c\u7684\u6587\u7ae0\u5c11\u65e9\u4e0a\u8f66\u65e9\u53d1\u8868\uff0c\u540e\u9762\u6587\u7ae0\u5927\u7206\u53d1\u53d1\u6587\u7684\u96be\u5ea6\u5c31\u4f1a\u589e\u5927\uff01<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#FF0000;font-weight:bold;mso-bidi-font-weight:bold;background:#FFFF00;mso-highlight:#FFFF00;\">\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u53ef\u4ee5\u6765\u627e\u5c0f\u9014\u505a\u8bbe\u8ba1\u54df<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;color:#FF0000;background:#FFFF00;mso-highlight:#FFFF00;\">~<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span>  <\/section>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017002\" data-ratio=\"1\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-03-10_\u300c\u8f6c\u300d\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'&from=appmsg\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017004\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-03-10_\u300c\u8f6c\u300d\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01\/12_7TvAyUibd1TPhJmZfialJtv6tu2SEg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100017003\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;height: auto !important;\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-03-10_\u300c\u8f6c\u300d\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u6316\u6398\uff1f\u505a\u7b2c\u4e00\u4e2a\u5403\u8783\u87f9\u7684\u4eba\uff01\u5357\u4eac\u533b\u79d1\u5927\u80bf\u7624\u533b\u96621\u533a7+\uff1a\u201c\u5355\u7ec6\u80de\u201d\u548c\u201c\u80bf\u7624\u5fae\u73af\u5883\u201d \u738b\u70b8\u7ec4\u5408\u76f8\u5f53\u7ed9\u529b\uff01\/13_9N02aBaau07RufXeXRLmvAHsrFZxtw.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" 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