{"id":50273,"date":"2024-06-16T09:50:25","date_gmt":"2024-06-16T01:50:25","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=50273"},"modified":"2024-06-16T09:50:25","modified_gmt":"2024-06-16T01:50:25","slug":"%e5%9c%a8%e4%bd%bf%e7%94%a8r%e8%af%ad%e8%a8%80%e7%8e%af%e5%a2%83%e4%b8%ad%e5%a6%82%e4%bd%95%e8%bf%9b%e8%a1%8c%e6%ad%a3%e6%80%81%e6%80%a7%e6%a3%80%e9%aa%8c%e7%9a%84%e4%bf%9d%e5%a7%86%e7%ba%a7-3","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=50273","title":{"rendered":"\u5728\u4f7f\u7528R\u8bed\u8a00\u73af\u5883\u4e2d\u5982\u4f55\u8fdb\u884c\u6b63\u6001\u6027\u68c0\u9a8c\u7684\u4fdd\u59c6\u7ea7\u6559\u7a0b"},"content":{"rendered":"<p><html><br \/>\n<head><br \/>\n<title><\/title><br \/>\n<meta charset=\"utf-8\"><br \/>\n<meta name=\"viewport\" 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flex-start;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(340deg) scale(0.65);margin-top: -4px;margin-bottom: -4px;transform-origin: center center;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 5px;padding-left: 2px;\">\n<section style=\"text-align: justify;color: rgb(239, 135, 135);font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"text-align: center;white-space: normal;\"><span style=\"font-size: 16px;\">\u70b9\u51fb\u84dd\u5b57\uff0c\u5173\u6ce8\u6211\u4eec<\/span><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(20deg);\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5728\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u4e2d\uff0c\u7ecf\u5e38\u9700\u8981\u8fdb\u884c\u5047\u8bbe\u68c0\u9a8c\u6765\u6bd4\u8f83\u4e0d\u540c\u7ec4\u95f4\u7684\u5dee\u5f02\u6216\u8005\u8fdb\u884c\u76f8\u5173\u6027\u5206\u6790\u3002\u5728\u8bb8\u591a\u5047\u8bbe\u68c0\u9a8c\u4e2d\uff0c\u5e38\u5e38\u8981\u6c42\u6570\u636e\u6ee1\u8db3\u6b63\u6001\u6027\u5047\u8bbe\uff0c\u5982t\u68c0\u9a8c\u3001ANOVA\u7b49\u3002\u56e0\u6b64\uff0c\u5bf9\u751f\u7269\u5b66\u6570\u636e\u8fdb\u884c\u6b63\u6001\u6027\u68c0\u9a8c\u662f\u5fc5\u8981\u7684\uff0c\u4ee5\u786e\u4fdd\u6240\u5e94\u7528\u7684\u7edf\u8ba1\u65b9\u6cd5\u7684\u51c6\u786e\u6027\u548c\u53ef\u9760\u6027\u3002<br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><span style=\"font-size: 18px;\"><strong>\u4ee5\u4e0b\u662f\u51e0\u79cd\u5e38\u89c1\u7684\u6b63\u6001\u6027\u68c0\u9a8c\u65b9\u6cd5\uff1a<\/strong><\/span><\/p>\n<p style=\"white-space: normal;\"><strong><span style=\"color: rgb(239, 135, 135);\">1. Shapiro-Wilk\u68c0\u9a8c\uff08Shapiro-Wilk Test\uff09\uff1a<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\">Shapiro-Wilk\u68c0\u9a8c\u662f\u4e00\u79cd\u7ecf\u5178\u7684\u6b63\u6001\u6027\u68c0\u9a8c\u65b9\u6cd5\uff0c\u9002\u7528\u4e8e\u8f83\u5c0f\u6837\u672c\uff08\u901a\u5e38\u4e0d\u8d85\u8fc75000\u4e2a\u89c2\u6d4b\u503c\uff09\u3002\u8be5\u68c0\u9a8c\u7684\u539f\u5047\u8bbe\u662f\u6570\u636e\u6765\u81ea\u6b63\u6001\u5206\u5e03\u3002\u5728\u4f7f\u7528Shapiro-Wilk\u68c0\u9a8c\u65f6\uff0c\u5982\u679cp-value\u5c0f\u4e8e\u8bbe\u5b9a\u7684\u663e\u8457\u6027\u6c34\u5e73\uff08\u901a\u5e38\u4e3a0.05\uff09\uff0c\u6211\u4eec\u4f1a\u62d2\u7edd\u539f\u5047\u8bbe\uff0c\u5373\u8ba4\u4e3a\u6570\u636e\u4e0d\u662f\u6765\u81ea\u6b63\u6001\u5206\u5e03\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><span style=\"color: rgb(239, 135, 135);\"><strong>2. Anderson-Darling\u68c0\u9a8c\uff08Anderson-Darling Test\uff09\uff1a<\/strong><\/span><\/p>\n<p style=\"white-space: normal;\">Anderson-Darling\u68c0\u9a8c\u4e5f\u662f\u4e00\u79cd\u7528\u4e8e\u6b63\u6001\u6027\u68c0\u9a8c\u7684\u65b9\u6cd5\uff0c\u9002\u7528\u4e8e\u8f83\u5c0f\u6837\u672c\u3002\u5b83\u5bf9\u6b63\u6001\u6027\u7684\u654f\u611f\u6027\u8f83\u9ad8\uff0c\u56e0\u6b64\u5728\u6837\u672c\u8f83\u5c0f\u7684\u60c5\u51b5\u4e0b\uff0c\u5e38\u5e38\u6bd4Shapiro-Wilk\u68c0\u9a8c\u66f4\u4e3a\u63a8\u8350\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><span style=\"color: rgb(239, 135, 135);\"><strong>3. Kolmogorov-Smirnov\u68c0\u9a8c\uff08Kolmogorov-Smirnov Test\uff09\uff1a<\/strong><\/span><\/p>\n<p style=\"white-space: normal;\">Kolmogorov-Smirnov\u68c0\u9a8c\u662f\u4e00\u79cd\u8f83\u4e3a\u901a\u7528\u7684\u5206\u5e03\u62df\u5408\u68c0\u9a8c\u65b9\u6cd5\uff0c\u53ef\u4ee5\u7528\u4e8e\u68c0\u9a8c\u6837\u672c\u662f\u5426\u6765\u81ea\u7279\u5b9a\u5206\u5e03\uff08\u5305\u62ec\u6b63\u6001\u5206\u5e03\uff09\u3002\u5728\u6b63\u6001\u6027\u68c0\u9a8c\u4e2d\uff0c\u6211\u4eec\u4f1a\u4f7f\u7528Kolmogorov-Smirnov\u68c0\u9a8c\u6765\u6bd4\u8f83\u6837\u672c\u7684\u7d2f\u79ef\u5206\u5e03\u51fd\u6570\uff08CDF\uff09\u4e0e\u7406\u8bba\u6b63\u6001\u5206\u5e03\u7684CDF\u4e4b\u95f4\u7684\u5dee\u5f02\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><span style=\"color: rgb(239, 135, 135);\"><strong>4. Lilliefors\u68c0\u9a8c\uff1a<\/strong><\/span><\/p>\n<p style=\"white-space: normal;\">Lilliefors\u68c0\u9a8c\u662f\u5bf9Kolmogorov-Smirnov\u68c0\u9a8c\u7684\u4fee\u6b63\uff0c\u9488\u5bf9\u5c0f\u6837\u672c\u60c5\u51b5\u4e0b\u7684\u6b63\u6001\u6027\u68c0\u9a8c\u3002\u5b83\u6bd4Kolmogorov-Smirnov\u68c0\u9a8c\u66f4\u9002\u7528\u4e8e\u5c0f\u6837\u672c\u6570\u636e\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><span style=\"color: rgb(239, 135, 135);\"><strong>5. Q-Q\u56fe\uff08Quantile-Quantile Plot\uff09\uff1a<\/strong><\/span><\/p>\n<p style=\"white-space: normal;\">Q-Q\u56fe\u4e0d\u662f\u4e25\u683c\u610f\u4e49\u4e0a\u7684\u7edf\u8ba1\u68c0\u9a8c\u65b9\u6cd5\uff0c\u800c\u662f\u4e00\u79cd\u53ef\u89c6\u5316\u5de5\u5177\uff0c\u7528\u4e8e\u68c0\u9a8c\u6570\u636e\u662f\u5426\u6765\u81ea\u67d0\u4e2a\u5206\u5e03\uff08\u901a\u5e38\u662f\u6b63\u6001\u5206\u5e03\uff09\u3002Q-Q\u56fe\u7ed8\u5236\u6837\u672c\u6570\u636e\u7684\u5206\u4f4d\u6570\u4e0e\u7406\u8bba\u5206\u5e03\u7684\u5206\u4f4d\u6570\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u5982\u679c\u6570\u636e\u6765\u81ea\u6b63\u6001\u5206\u5e03\uff0c\u70b9\u5728Q-Q\u56fe\u4e0a\u5e94\u8be5\u5927\u81f4\u6cbf\u7740\u4e00\u6761\u76f4\u7ebf\u5206\u5e03\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\">\u5728\u751f\u7269\u4fe1\u606f\u5b66\u4e2d\uff0c\u6b63\u6001\u6027\u68c0\u9a8c\u662f\u4e00\u79cd\u5e38\u7528\u7684\u7edf\u8ba1\u65b9\u6cd5\uff0c\u7528\u4e8e\u9a8c\u8bc1\u751f\u7269\u5b66\u6570\u636e\u662f\u5426\u8fd1\u4f3c\u4e8e\u6b63\u6001\u5206\u5e03\u3002\u6b63\u6001\u6027\u68c0\u9a8c\u5728\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u4e2d\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u5c24\u5176\u5728\u9ad8\u901a\u91cf\u6570\u636e\u5206\u6790\u4e2d\uff0c\u5982\u57fa\u56e0\u8868\u8fbe\u6570\u636e\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u6570\u636e\u548c\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e\u7b49\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;background-color: rgb(255, 255, 255);overflow: hidden;padding-top: 5px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: center;display: flex;flex-flow: row nowrap;margin-bottom: 5px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(340deg) scale(0.65);margin-top: -4px;margin-bottom: -4px;transform-origin: center center;\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 5px;padding-left: 2px;\">\n<section style=\"text-align: justify;letter-spacing: 2px;color: rgb(239, 135, 135);font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"text-align: center;white-space: normal;\"><em>\u57fa\u56e0\u8868\u8fbe\u6570\u636e<\/em><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(20deg);\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;margin-top: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: rgb(242, 206, 206);padding-bottom: 5px;\">\n<section style=\"display: flex;flex-flow: row nowrap;text-align: center;justify-content: center;margin-top: -7px;margin-bottom: -12px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-left: -4px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 206, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -16px;margin-left: -10px;z-index: 1;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-left: -10px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 206, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -16px;margin-right: -10px;margin-left: -10px;z-index: 1;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 206, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -16px;margin-left: -10px;z-index: 1;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-left: -10px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 206, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -16px;margin-right: -10px;margin-left: -10px;z-index: 1;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;margin-right: -4px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 206, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u5728\u57fa\u56e0\u8868\u8fbe\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u7ecf\u5e38\u9700\u8981\u6bd4\u8f83\u4e0d\u540c\u57fa\u56e0\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u5bf9\u4e8e\u6bcf\u4e2a\u57fa\u56e0\u7684\u8868\u8fbe\u503c\uff0c\u53ef\u4ee5\u5e94\u7528\u6b63\u6001\u6027\u68c0\u9a8c\u6765\u9a8c\u8bc1\u5176\u662f\u5426\u8fd1\u4f3c\u4e8e\u6b63\u6001\u5206\u5e03\uff0c\u4ece\u800c\u786e\u5b9a\u662f\u5426\u53ef\u4ee5\u4f7f\u7528t\u68c0\u9a8c\u3001\u65b9\u5dee\u5206\u6790\u7b49\u65b9\u6cd5\u8fdb\u884c\u5dee\u5f02\u8868\u8fbe\u5206\u6790\u3002<\/p>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u793a\u4f8b\uff1a<\/strong><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u5b89\u88c5\u5e76\u52a0\u8f7d airway \u5305<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; install.packages(<span class=\"code-snippet__string\">\"airway\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">&gt; library(airway)<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u4f7f\u7528 airway \u6570\u636e\u96c6\u7684 gene \u8868\u8fbe\u503c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; gene_expression &lt;- airway$gene<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u4f7f\u7528 Shapiro-Wilk \u6b63\u6001\u6027\u68c0\u9a8c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; shapiro_test_result &lt;- shapiro.test(gene_expression)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u67e5\u770b Shapiro-Wilk \u68c0\u9a8c\u7ed3\u679c\u7684 p-value<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; p_value_shapiro &lt;- shapiro_test_result$p.value<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u8f93\u51fa p-value<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; print(p_value_shapiro)<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u53ef\u89c6\u5316\u57fa\u56e0\u8868\u8fbe\u503c\u7684\u5206\u5e03\u60c5\u51b5<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; ggplot(data.frame(gene_expression), aes(x = gene_expression)) +<\/span><\/code><code><span class=\"code-snippet_outer\">+ geom_histogram(bins = <span class=\"code-snippet__number\">30<\/span>) +<\/span><\/code><code><span class=\"code-snippet_outer\">+ theme_minimal()<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7074766355140187\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_EKamSaYLXwvBUA5xAWT4X974EicWSg-5.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXkJ2QRMAEABYXSia42VzDdyKKQAZpMQcexcHWvyMXmWBJ2diaEKamSaYLXwvBUA5xAWT4X974EicWSg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1070\" style=\"vertical-align: middle;width: 100%;\"  data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">R\u4e2d\u7684airway\u6570\u636e\u96c6\u662fairway\u5305\u4e2d\u63d0\u4f9b\u7684\u4e00\u4e2a\u57fa\u56e0\u8868\u8fbe\u6570\u636e\u96c6\uff0c\u5305\u542b\u4e86\u5728\u4eba\u652f\u6c14\u7ba1\u4e0a\u76ae\u7ec6\u80de\u4e2d\u8fdb\u884c\u751f\u7269\u5b66\u5b9e\u9a8c\u7684\u57fa\u56e0\u8868\u8fbe\u503c\u3002\u5728\u8fd9\u4e2a\u4f8b\u5b50\u4e2d\uff0c\u6211\u4eec\u4f7f\u7528\u4e86airway\u6570\u636e\u96c6\u4e2d\u7684gene\u5217\u4f5c\u4e3a\u57fa\u56e0\u8868\u8fbe\u503c\uff0c\u7136\u540e\u6267\u884c\u4e86Shapiro-Wilk\u6b63\u6001\u6027\u68c0\u9a8c\uff0c\u67e5\u770b\u57fa\u56e0\u8868\u8fbe\u503c\u662f\u5426\u6ee1\u8db3\u6b63\u6001\u5206\u5e03\u3002\u540c\u65f6\uff0c\u6211\u4eec\u4f7f\u7528\u76f4\u65b9\u56fe\u53ef\u89c6\u5316\u4e86\u57fa\u56e0\u8868\u8fbe\u503c\u7684\u5206\u5e03\u60c5\u51b5\u3002<br  \/><\/p>\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;background-color: rgb(255, 255, 255);overflow: hidden;padding-top: 5px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: center;display: flex;flex-flow: row nowrap;margin-bottom: 5px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(340deg) scale(0.65);margin-top: -4px;margin-bottom: -4px;transform-origin: center center;\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 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inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 206, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -16px;margin-right: -10px;margin-left: -10px;z-index: 1;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\"><svg viewbox=\"0 0 1 1\" 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33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-left: -10px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 206, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -16px;margin-right: -10px;margin-left: -10px;z-index: 1;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;margin-right: -4px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 206, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u5728\u86cb\u767d\u8d28\u7ec4\u5b66\u7814\u7a76\u4e2d\uff0c\u5982\u8d28\u8c31\u6570\u636e\u5206\u6790\uff0c\u6211\u4eec\u53ef\u80fd\u4f1a\u68c0\u6d4b\u6570\u767e\u6216\u6570\u5343\u4e2a\u86cb\u767d\u8d28\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u5bf9\u4e8e\u8fd9\u4e9b\u6570\u636e\uff0c\u6211\u4eec\u53ef\u4ee5\u4f7f\u7528\u6b63\u6001\u6027\u68c0\u9a8c\u6765\u8bc4\u4f30\u6bcf\u4e2a\u86cb\u767d\u8d28\u7684\u8868\u8fbe\u662f\u5426\u6ee1\u8db3\u6b63\u6001\u5206\u5e03\uff0c\u4ece\u800c\u4e3a\u540e\u7eed\u7684\u5dee\u5f02\u5206\u6790\u548c\u86cb\u767d\u8d28\u529f\u80fd\u5bcc\u96c6\u5206\u6790\u63d0\u4f9b\u57fa\u7840\u3002<\/p>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u793a\u4f8b\uff1a<\/strong><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u5b89\u88c5\u5e76\u52a0\u8f7d Vim \u5305<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; install.packages(<span class=\"code-snippet__string\">\"Vim\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">&gt; library(Vim)<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u5bfc\u5165 P100 \u6570\u636e\u96c6<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; data(P100)<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u53d6\u51fa\u86cb\u767d\u8d28\u7ec4\u5b66\u6570\u636e\u4f5c\u4e3a\u57fa\u56e0\u8868\u8fbe\u503c\uff08\u4ee3\u66ff\u57fa\u56e0\u8868\u8fbe\u6570\u636e\uff09<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; protein_expression &lt;- P100<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u4f7f\u7528 Shapiro-Wilk \u6b63\u6001\u6027\u68c0\u9a8c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; shapiro_test_result &lt;- shapiro.test(protein_expression)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u67e5\u770b Shapiro-Wilk \u68c0\u9a8c\u7ed3\u679c\u7684 p-value<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; p_value_shapiro &lt;- shapiro_test_result$p.value<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u8f93\u51fa p-value<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; print(p_value_shapiro)<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u53ef\u89c6\u5316\u86cb\u767d\u8d28\u7ec4\u5b66\u6570\u636e\u7684\u5206\u5e03\u60c5\u51b5<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; ggplot(data.frame(protein_expression), aes(x = protein_expression)) +<\/span><\/code><code><span class=\"code-snippet_outer\">+ geom_histogram(bins = <span class=\"code-snippet__number\">30<\/span>) +<\/span><\/code><code><span class=\"code-snippet_outer\">+ theme_minimal()<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7164948453608248\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_hMkQe2PlFsoZqxS7TjIJ5ODK5cicgA-5.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXkJ2QRMAEABYXSia42VzDdy11RWgrjXD32nH9czF9AldqXEshMkQe2PlFsoZqxS7TjIJ5ODK5cicgA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"388\" style=\"vertical-align: middle;width: 100%;\"  data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\">\u5728R\u4e2d\uff0c\u53ef\u4ee5\u4f7f\u7528P100\u6570\u636e\u96c6\uff0c\u5b83\u5305\u542b\u4e86\u4eba\u7c7b\u6dcb\u5df4\u7ec6\u80de\u7cfb\u5217\u4e2d\u7684\u86cb\u767d\u8d28\u7ec4\u5b66\u6570\u636e\uff0c\u662f\u4e00\u4e2a\u5e7f\u6cdb\u7528\u4e8e\u7edf\u8ba1\u548c\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u7684\u793a\u4f8b\u6570\u636e\u96c6\u3002\u7136\u540e\u6267\u884c\u4e86Shapiro-Wilk\u6b63\u6001\u6027\u68c0\u9a8c\uff0c\u67e5\u770b\u86cb\u767d\u8d28\u7ec4\u5b66\u6570\u636e\u662f\u5426\u6ee1\u8db3\u6b63\u6001\u5206\u5e03\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;background-color: rgb(255, 255, 255);overflow: hidden;padding-top: 5px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: center;display: flex;flex-flow: row nowrap;margin-bottom: 5px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(340deg) scale(0.65);margin-top: -4px;margin-bottom: -4px;transform-origin: center center;\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 5px;padding-left: 2px;\">\n<section style=\"text-align: justify;letter-spacing: 2px;color: rgb(239, 135, 135);font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"text-align: center;white-space: normal;\"><em>\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e<\/em><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(20deg);\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;margin-top: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: rgb(242, 206, 206);padding-bottom: 5px;\">\n<section style=\"display: flex;flex-flow: row nowrap;text-align: center;justify-content: center;margin-top: -7px;margin-bottom: -12px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-left: -4px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 206, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -16px;margin-left: -10px;z-index: 1;\">\n<section style=\"\" 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style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -16px;margin-right: -10px;margin-left: -10px;z-index: 1;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: 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style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-left: -10px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 206, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -16px;margin-right: -10px;margin-left: -10px;z-index: 1;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;margin-right: -4px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 33px;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 206, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u4ee3\u8c22\u7ec4\u5b66\u7814\u7a76\u6d89\u53ca\u5230\u5927\u91cf\u7684\u4ee3\u8c22\u4ea7\u7269\u6d4b\u91cf\u6570\u636e\uff0c\u901a\u5e38\u7528\u4e8e\u8bc6\u522b\u751f\u7269\u6837\u672c\u7684\u4ee3\u8c22\u7ec4\u6210\u3002\u5728\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e\u5206\u6790\u4e2d\uff0c\u6b63\u6001\u6027\u68c0\u9a8c\u53ef\u7528\u4e8e\u9a8c\u8bc1\u6bcf\u4e2a\u4ee3\u8c22\u4ea7\u7269\u7684\u6d4b\u91cf\u503c\u662f\u5426\u7b26\u5408\u6b63\u6001\u5206\u5e03\uff0c\u4ece\u800c\u51b3\u5b9a\u662f\u5426\u9002\u5408\u5e94\u7528t\u68c0\u9a8c\u6216\u76f8\u5173\u6027\u5206\u6790\u7b49\u65b9\u6cd5\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u793a\u4f8b\uff1a<\/strong><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u5b89\u88c5\u5e76\u52a0\u8f7d MetaboAnalystR \u5305<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; install.packages(<span class=\"code-snippet__string\">\"MetaboAnalystR\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">&gt; library(MetaboAnalystR)<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u5bfc\u5165 ms.data \u6570\u636e\u96c6<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; data(ms.data)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u53d6\u51fa\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e\u4f5c\u4e3a\u57fa\u56e0\u8868\u8fbe\u503c\uff08\u4ee3\u66ff\u57fa\u56e0\u8868\u8fbe\u6570\u636e\uff09<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; metabolomics_data &lt;- ms.data$peakTable<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u4f7f\u7528 Shapiro-Wilk \u6b63\u6001\u6027\u68c0\u9a8c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; shapiro_test_result &lt;- shapiro.test(metabolomics_data)<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u67e5\u770b Shapiro-Wilk \u68c0\u9a8c\u7ed3\u679c\u7684 p-value<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; p_value_shapiro &lt;- shapiro_test_result$p.value<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u8f93\u51fa p-value<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; print(p_value_shapiro)<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u53ef\u89c6\u5316\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e\u7684\u5206\u5e03\u60c5\u51b5<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">&gt; ggplot(data.frame(metabolomics_data), aes(x = metabolomics_data)) +<\/span><\/code><code><span class=\"code-snippet_outer\">+ &nbsp;geom_histogram(bins = <span class=\"code-snippet__number\">30<\/span>) +<\/span><\/code><code><span class=\"code-snippet_outer\">+ &nbsp;theme_minimal()<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.4737762237762238\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_6gG4TNCh4rwWraZrnib9lvezUpczdg-5.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXkJ2QRMAEABYXSia42VzDdySkTibLoKhs52pVdWia89vbHKSAR6gG4TNCh4rwWraZrnib9lvezUpczdg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"572\" style=\"vertical-align: middle;width: 100%;\"  data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5728R\u4e2d\uff0c\u53ef\u4ee5\u4f7f\u7528ms.data\u6570\u636e\u96c6\uff0c\u5b83\u5305\u542b\u4e86\u4ee3\u8c22\u7ec4\u5b66\u5b9e\u9a8c\u4e2d\u7684\u8d28\u8c31\u6570\u636e\uff0c\u662f\u4e00\u4e2a\u7528\u4e8e\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\u7684\u793a\u4f8b\u6570\u636e\u96c6\u3002\u7136\u540e\u6267\u884c\u4e86Shapiro-Wilk\u6b63\u6001\u6027\u68c0\u9a8c\uff0c\u67e5\u770b\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e\u662f\u5426\u6ee1\u8db3\u6b63\u6001\u5206\u5e03\u3002<br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\">\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u5728\u8fdb\u884c\u6b63\u6001\u6027\u68c0\u9a8c\u65f6\uff0c\u6837\u672c\u5927\u5c0f\u5bf9\u68c0\u9a8c\u7ed3\u679c\u7684\u5f71\u54cd\u8f83\u5927\u3002\u5bf9\u4e8e\u5927\u6837\u672c\uff0c\u5373\u4f7f\u6570\u636e\u4e0d\u5b8c\u5168\u7b26\u5408\u6b63\u6001\u5206\u5e03\uff0c\u67d0\u4e9b\u7edf\u8ba1\u65b9\u6cd5\u7684\u5047\u8bbe\u6761\u4ef6\u4e5f\u53ef\u80fd\u5f97\u5230\u6ee1\u8db3\u3002\u6b64\u5916\uff0c\u751f\u7269\u5b66\u6570\u636e\u5f80\u5f80\u53d7\u5230\u591a\u79cd\u56e0\u7d20\u7684\u8c03\u63a7\u548c\u566a\u58f0\u7684\u5e72\u6270\uff0c\u56e0\u6b64\u5373\u4f7f\u6570\u636e\u4e0d\u662f\u4e25\u683c\u7684\u6b63\u6001\u5206\u5e03\uff0c\u6709\u65f6\u4e5f\u53ef\u4ee5\u5728\u5408\u7406\u8303\u56f4\u5185\u8fdb\u884c\u6570\u636e\u5206\u6790\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\">\u4ee5\u4e0a\u5c31\u662f\u5bf9normality test\u7684\u7b80\u5355\u4ecb\u7ecd\u5566\uff0c\u6b63\u6001\u6027\u68c0\u9a8c\uff08normality test\uff09\u662f\u7edf\u8ba1\u5b66\u4e2d\u5e38\u7528\u7684\u4e00\u79cd\u68c0\u9a8c\u65b9\u6cd5\uff0c\u7528\u4e8e\u68c0\u9a8c\u4e00\u4e2a\u6837\u672c\u662f\u5426\u6765\u81ea\u6b63\u6001\u5206\u5e03\uff08\u5373\u9ad8\u65af\u5206\u5e03\uff09\u3002\u5728\u8bb8\u591a\u7edf\u8ba1\u65b9\u6cd5\u4e2d\uff0c\u5047\u8bbe\u6570\u636e\u6765\u81ea\u6b63\u6001\u5206\u5e03\u662f\u4e00\u4e2a\u5e38\u89c1\u7684\u524d\u63d0\u6761\u4ef6\uff0c\u5982t\u68c0\u9a8c\u3001\u65b9\u5dee\u5206\u6790\u7b49\u3002\u5728\u4f7f\u7528\u8fd9\u4e9b\u65b9\u6cd5\u4e4b\u524d\uff0c\u6211\u4eec\u9700\u8981\u5148\u9a8c\u8bc1\u6570\u636e\u662f\u5426\u6ee1\u8db3\u6b63\u6001\u6027\u5047\u8bbe\u3002\u5728\u63a2\u7d22\u6027\u6570\u636e\u5206\u6790\u4e2d\uff0c\u4e86\u89e3\u6570\u636e\u7684\u5206\u5e03\u60c5\u51b5\u5bf9\u4e8e\u6570\u636e\u5206\u6790\u81f3\u5173\u91cd\u8981\u3002\u6b63\u6001\u6027\u68c0\u9a8c\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u786e\u5b9a\u6570\u636e\u662f\u5426\u8fd1\u4f3c\u4e8e\u6b63\u6001\u5206\u5e03\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\">\u5c0f\u4f19\u4f34\u4eec\uff0c\u4eca\u5929\u6709\u6ca1\u6709\u5b66\u5230\u65b0\u77e5\u8bc6\u5462\uff0c\u60f3\u8981\u7ee7\u7eed\u4e86\u89e3R\u8bed\u8a00\u5185\u5bb9\u53ef\u4ee5\u6301\u7eed\u5173\u6ce8\u5c0f\u5e08\u59b9\u54e6\uff5e\uff5e\u6216\u8005\u4e5f\u53ef\u4ee5\u5173\u6ce8\u6211\u4eec\u7684\u5b98\u7f51\u4e5f\u4f1a\u6301\u7eed\u66f4\u65b0\u7684\u54e6\uff5e http:\/\/www.biocloudservice.com\/home.html<\/p>\n<\/section>\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;height: auto;background-color: rgb(255, 255, 255);overflow: hidden;padding-top: 5px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: center;display: flex;flex-flow: row nowrap;margin-bottom: 5px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(340deg) scale(0.65);margin-top: -4px;margin-bottom: -4px;transform-origin: center center;\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 5px;padding-left: 2px;\">\n<section style=\"text-align: justify;letter-spacing: 2px;color: rgb(239, 135, 135);font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"text-align: center;white-space: normal;\"><em>References:<\/em><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(20deg);\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;margin-top: 15px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: rgb(241, 187, 186);padding-bottom: 5px;\">\n<section style=\"display: flex;flex-flow: row nowrap;text-align: center;justify-content: center;margin-top: -10px;margin-bottom: -8px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;height: auto;align-self: flex-start;border-width: 0px;margin-left: -4px;\">\n<section style=\"display: inline-block;width: 100%;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(240, 187, 186);\" powered-by=\"xiumi.us\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -13px;margin-left: -3.0005%;z-index: 1;\">\n<section style=\"display: inline-block;width: 100%;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\" powered-by=\"xiumi.us\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;height: auto;align-self: flex-start;border-width: 0px;margin-left: -3.0005%;\">\n<section style=\"display: inline-block;width: 100%;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(240, 187, 186);\" powered-by=\"xiumi.us\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -13px;margin-right: -3.0005%;margin-left: -3.0005%;z-index: 1;\">\n<section style=\"display: inline-block;width: 100%;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\" powered-by=\"xiumi.us\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;height: auto;align-self: flex-start;border-width: 0px;\">\n<section style=\"display: inline-block;width: 100%;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(240, 187, 186);\" powered-by=\"xiumi.us\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -13px;margin-left: -3.0005%;z-index: 1;\">\n<section style=\"display: inline-block;width: 100%;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\" powered-by=\"xiumi.us\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;height: auto;align-self: flex-start;border-width: 0px;margin-left: -3.0005%;\">\n<section style=\"display: inline-block;width: 100%;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(240, 187, 186);\" powered-by=\"xiumi.us\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;height: auto;align-self: flex-start;border-width: 0px;margin-top: -13px;margin-right: -3.0005%;margin-left: -3.0005%;z-index: 1;\">\n<section style=\"display: inline-block;width: 100%;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgba(255, 255, 255, 0) rgba(255, 255, 255, 0) rgb(239, 135, 135);background-color: rgba(255, 255, 255, 0);\" powered-by=\"xiumi.us\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;height: auto;margin-right: -4px;\">\n<section style=\"display: inline-block;width: 100%;height: 25px;vertical-align: top;overflow: hidden;border-style: solid;border-width: 2px;border-radius: 50%;border-color: rgb(239, 135, 135) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(240, 187, 186);\" powered-by=\"xiumi.us\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row nowrap;margin-top: 15px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;padding-right: 20px;padding-left: 20px;\">\n<section style=\"text-align: justify;color: rgb(217, 92, 93);\" powered-by=\"xiumi.us\">\n<ol class=\"list-paddingleft-1\" style=\"padding-left: 40px;list-style-position: outside;\">\n<li>\n<p>https:\/\/erj.ersjournals.com\/content\/early\/2020\/07\/06\/13993003.01123-2020<\/p>\n<\/li>\n<li>\n<p>https:\/\/www.google.com.hk\/url?sa=i&#038;url=https%3A%2F%2Fwww.researchgate.net%2Ffigure%2FFrequency-distribution-of-total-protein-concentrations-in-9825-paired-samples-with-a_fig4_308727916&#038;psig=AOvVaw32ENkak44GlJyIWOieaiLc&#038;ust=1689927799804000&#038;source=images&#038;cd=vfe&#038;opi=89978449&#038;ved=0CA4QjRxqFwoTCLDt7eTtnIADFQAAAAAdAAAAABAP<\/p>\n<\/li>\n<li>\n<p>https:\/\/www.google.com.hk\/url?sa=i&#038;url=https%3A%2F%2Fstackoverflow.com%2Fquestions%2F6967664%2Fggplot2-histogram-with-normal-curve&#038;psig=AOvVaw1yNYuFjrzI5EpWo2VUuqFj&#038;ust=1689928481937000&#038;source=images&#038;cd=vfe&#038;opi=89978449&#038;ved=0CA4QjRxqFwoTCNjytr3wnIADFQAAAAAdAAAAABAY<\/p>\n<\/li>\n<\/ol>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><a target=\"_blank\" 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