{"id":50486,"date":"2024-06-16T09:51:44","date_gmt":"2024-06-16T01:51:44","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=50486"},"modified":"2024-06-16T09:51:44","modified_gmt":"2024-06-16T01:51:44","slug":"nature-communications%ef%bc%81%e5%8d%95%e7%bb%86%e8%83%9e%e7%ba%af%e7%94%9f%e4%bf%a1%e8%bf%98%e6%9c%89%e4%bb%80%e4%b9%88%e8%8a%b1%e6%a0%b7%ef%bc%9f%e7%91%9e%e9%87%91%e5%8c%bb%e9%99%a2%e8%81%94-2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=50486","title":{"rendered":"Nature communications\uff01\u5355\u7ec6\u80de\u7eaf\u751f\u4fe1\u8fd8\u6709\u4ec0\u4e48\u82b1\u6837\uff1f\u745e\u91d1\u533b\u9662\u8054\u5408bulk\u548cCUT&Tag\u6570\u636e\uff0c0\u5b9e\u9a8c\u53d116+\uff01"},"content":{"rendered":"


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style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\uff01\uff01\u8fd8\u5728\u5bfb\u627e\u80bf\u7624\u53d1\u6587\u597d\u601d\u8def\u7684\u670b\u53cb\u4eec\u8d76\u7d27\u6536\u85cf\u8d77\u6765\u5427\uff0c\u9ad8\u5206\u6587\u7ae0\u7b49\u7740\u4f60\uff01<\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#0070C0;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\">\uff08ps\uff1a\u60f3\u8981\u4e86\u89e3\u6700\u65b0\u7684\u751f\u4fe1\u601d\u8def\uff0c\u6765\u627e\u9986\u957f\u5c31\u5bf9\u4e86\uff0c\u8fd9\u91cc\u6709\u4e0d\u4ec5\u6709\u70ed\u70b9\u65b9\u5411\u8fd8\u6709\u521b\u65b0\u601d\u8def\uff0c\u60f3\u601d\u8def\u590d\u73b0\u53ef\u4ee5\u76f4\u63a5\u626b\u7801call\u9986\u957f\uff0c\u7b49\u4f60\u54e6\uff01\uff09<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100006476\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_f6PG40Qrdu5e9B1iaIMItPiajABYWA-4.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxqaqPbQprPd4vw8Ytp0cprbzXiakMDdFriaB6B59ibhlBCrNyQFf6PG40Qrdu5e9B1iaIMItPiajABYWA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 175px;height: 175px;\" data-recalc-dims=\"1\" \/><span style=\"font-family: \u7b49\u7ebf;font-size: 10.5pt;letter-spacing: 0.034em;text-align: justify;text-indent: 0pt;\">   <\/span><\/p>\n<section style=\"text-align: center;line-height: 1.75em;margin-bottom: 24px;\"><span style=\"font-family: \u7b49\u7ebf;font-size: 10.5pt;text-align: justify;text-indent: 0pt;letter-spacing: 0.034em;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009648\" data-ratio=\"0.4212962962962963\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_aGWiaibULgDkTTofY3uqyfR9THFhZA-4.png?resize=553%2C233\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx5w20Uia6K384SRvofkPy5fkaUmW2JGXp67djjN7SloTWOKmgYaGWiaibULgDkTTofY3uqyfR9THFhZA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"233 .27001953125\" width=\"553 .739990234375\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u25cf \u9898\u76ee\uff1a\u7ec6\u80de\u5c42\u6b21\u7ed3\u6784\u63ed\u793a\u6025\u6027\u65e9\u5e7c\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u4e2d\u7684\u767d\u8840\u75c5\u5e72\u6837\u7ec6\u80de\u548c\u65e9\u671f\u6b7b\u4ea1\u98ce\u9669<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u25cf \u6742\u5fd7\uff1a<\/span><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-style:italic;mso-bidi-font-style:italic;\">nature communications<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u25cf \u5f71\u54cd\u56e0\u5b50\uff1aIF=16.6<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u25cf \u53d1\u8868\u65f6\u95f4\uff1a2024\u5e742\u6708<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(2, 30, 170);\">\u7814\u7a76\u80cc\u666f<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(2, 30, 170);\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u6025\u6027\u65e9\u5e7c\u7c92\u7ec6\u80de\u767d\u8840\u75c5\uff08APL\uff09\u662f\u9776\u5411\u5206\u5316\u6cbb\u7597\u7684\u5178\u8303\uff0c\u5c11\u6570\u60a3\u8005\u6cbb\u7597\u5931\u8d25\u751a\u81f3\u65e9\u671f\u6b7b\u4ea1\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(2, 30, 170);\">\u6570\u636e\u6765\u6e90<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(2, 30, 170);\"><br \/><\/span><\/section>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"567\" style=\"border-width: initial;border-style: none;border-color: initial;border-collapse: collapse;width: 100%;\">\n<tbody>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#8EABDC;border-top:double #4472C4 1.5pt;border-left:double #4472C4 1.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\">\u6570\u636e\u96c6\/\u961f\u5217<\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#8EABDC;border-top:double #4472C4 1.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\">\u6570\u636e\u5e93<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#8EABDC;border-top:double #4472C4 1.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\">\u6570\u636e\u7c7b\u578b<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#8EABDC;border-top:double #4472C4 1.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:double #4472C4 1.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\">\u8be6\u7ec6\u4fe1\u606f<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:double #4472C4 1.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">HRA003777<\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">NGDC<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">scRNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:double #4472C4 1.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">16\u4e2aAPL\u9aa8\u9ad3\u6837\u672c<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:double #4472C4 1.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE120221<\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">scRNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:double #4472C4 1.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">20 \u540d\u4e0d\u540c\u5e74\u9f84\u6bb5\u7684\u5065\u5eb7\u6210\u5e74\u4eba\u7c7b\u4f9b\u4f53\u7684\u4eba\u9aa8\u9ad3\u7ec6\u80de<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:double #4472C4 1.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE130116<\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">scRNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:double #4472C4 1.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u6837\u672c\u548c\u5065\u5eb7\u9aa8\u9ad3\u4f9b\u4f53\u6837\u672c<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:double #4472C4 1.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE172057<\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">scRNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:double #4472C4 1.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">348 \u540d APL \u60a3\u8005<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:double #4472C4 1.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE195776<\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">CUT&Tag-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:double #4472C4 1.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;\">319 \u4efd APL\u3001393 \u4efd\u975e APL \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5 \u548c 700 \u4efd\u975e\u80bf\u7624\u5bf9\u7167<\/span><\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\">          <o:p> <\/o:p><\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(2, 30, 170);\">\u7814\u7a76\u601d\u8def<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(2, 30, 170);\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u5bf9\u91c7\u96c6\u81ea 16 \u540d\u65b0\u786e\u8bca APL \u60a3\u8005\u7684\u9aa8\u9ad3\uff08BM\uff09\u6837\u672c\u8fdb\u884c\u4e86\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5206\u6790\u3002\u540c\u65f6\uff0c\u91cd\u65b0\u5206\u6790\u4e86 23 \u4e2a\u72ec\u7acb\u7684\u5065\u5eb7\u4eba\u6b63\u5e38 BM \u6837\u672c\u7684 scRNA-seq \u6570\u636e\uff08GSE120221 \u548c GSE130116\uff09\uff0c\u6784\u5efa\u4e86\u6b63\u5e38\u9020\u8840\u7ec6\u80de\u7fa4\u4f5c\u4e3a\u5bf9\u7167\u3002\u57fa\u4e8e\u672c\u7814\u7a76\u8868\u5f81\u7684 APL \u75c5\u7076\uff0c\u9996\u5148\u6784\u5efa\u4e86 APL \u75c5\u7076\u7684\u7ec6\u80de\u7ed3\u6784\u548c\u5206\u5316\u8f68\u8ff9\uff0c\u91cd\u70b9\u662f\u8bc6\u522b APL \u5e72\u6837\u7ec6\u80de\u3002\u4f7f\u7528\u9776\u5411 scRNA-seq (scTarget) \u9a8c\u8bc1\u4e86\u4e24\u540d\u65b0\u53d1 APL \u60a3\u8005\u4e2d PML\/RAR\u03b1 \u878d\u5408\u57fa\u56e0\u548c FLT3-ITD \u7684\u8868\u8fbe\u3002\u901a\u8fc7\u5bf9 323 \u4f8b APL \u60a3\u8005\u8fdb\u884c\u89e3\u5377\u79ef\u5206\u6790\uff0c\u786e\u5b9a\u4e86\u7ec6\u80de\u7ec4\u6210\u4e0e\u4e34\u5e8a\u8868\u73b0\u4e4b\u95f4\u7684\u5173\u8054\u3002\u63a5\u7740\u63a2\u8ba8\u4e86 ATRA \u6cbb\u7597\u5bf9\u4e09\u540d\u60a3\u8005\u5728\u53d1\u75c5\u65f6\u548c ATRA \u6cbb\u7597\u540e\u7b2c 2 \u5929\u7ec6\u80de\u7ec4\u6210\u53d8\u5316\u7684\u5f71\u54cd\u3002\u53c8\u5bf9 10 \u540d\u65b0\u786e\u8bca\u7684 APL \u60a3\u8005\u5728 ATRA \u6cbb\u7597\u524d\u540e\u7684 RNA-seq \u6570\u636e\u8fdb\u884c\u4e86\u89e3\u5377\u79ef\u5206\u6790\uff0c\u4ee5\u786e\u5b9a\u7ec6\u80de\u7ec4\u6210\uff08\u5c24\u5176\u662f APL \u5e72\u6837\u7ec6\u80de\uff09\u4e0e\u4f53\u5185 ATRA \u53cd\u5e94\u4e4b\u95f4\u7684\u5173\u8054\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(2, 30, 170);\">\u4e3b\u8981\u7ed3\u679c<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(2, 30, 170);\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\">1. APL \u539f\u59cb\u7ec6\u80de\u7684\u5355\u7ec6\u80de\u7279\u5f81\u63cf\u8ff0<\/span><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u9996\u5148\u5c06\u91c7\u96c6\u81ea APL \u60a3\u8005\u548c\u5065\u5eb7\u4eba\u7684\u9aa8\u9ad3\u6837\u672c\u8fdb\u884c\u4e86\u6bd4\u8f83\u5206\u6790\u3002\u4f7f\u7528\u6b63\u5e38 BM \u6837\u672c\u5efa\u7acb\u4e86\u7ec6\u80de\u591a\u6837\u6027\u57fa\u7ebf\uff0c\u53d1\u73b0\u4e86\u4e03\u4e2a\u4e3b\u8981\u7ec6\u80de\u7fa4\u3002\u8fd9\u4e9b\u7ec6\u80de\u7fa4\u5305\u62ec\u9020\u8840\u5e72\u7ec6\u80de\/\u7956\u7ec6\u80de\uff08HSPCs\uff09\u3001GMPs\u3001\u5355\u6838\u7ec6\u80de\uff08Mono\uff09\u3001\u6811\u7a81\u72b6\u7ec6\u80de\uff08DCs\uff09\u3001B \u7ec6\u80de\u3001T\/\u6740\u4f24\u7ec6\u80de\uff08NK\uff09\u548c\u7ea2\u7ec6\u80de\uff08Ery\uff09\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u63a5\u4e0b\u6765\uff0c\u5229\u7528 UMAP \u5c06APL \u60a3\u8005\u7684\u7ec6\u80de\u4ee5\u53ca\u6b63\u5e38\u9020\u8840\u7ec6\u80de\u7fa4\u6295\u5c04\u5230\u4e8c\u7ef4\u7a7a\u95f4\uff08\u56fe 1b\uff09\u3002APL \u60a3\u8005\u7684\u6dcb\u5df4\u7ec6\u80de\u548c\u7ea2\u7ec6\u80de\u5f62\u6210\u7684\u7ec6\u80de\u7fa4\u4e0e\u6b63\u5e38\u9020\u8840\u7ec6\u80de\u6ce8\u91ca\u7684\u7ec6\u80de\u7c7b\u578b\u76f8\u5bf9\u5e94\uff0c\u800c APL \u7ec6\u80de\u5219\u4e3b\u8981\u5f52\u5165\u4e00\u4e2a\u72ec\u7279\u7684\u7ec6\u80de\u7fa4\u3002\u4f7f\u7528 PML\/RAR\u03b1 \u9776\u5411 scRNA-seq \u6280\u672f\u5728\u4e24\u4e2a APL \u60a3\u8005\u6837\u672c\u4e2d\u89c2\u5bdf\u5230 PML\/RAR\u03b1 \u7684\u5355\u72ec\u8868\u8fbe\uff0c\u8fd9\u8bc1\u5b9e\u4e86 APL \u7ec6\u80de\u7fa4\u9274\u5b9a\u7684\u51c6\u786e\u6027\uff08\u56fe 1b\uff09\u3002\u8be5\u7ec6\u80de\u7fa4\u8868\u73b0\u51fa MPO \u57fa\u56e0\u7684\u9ad8\u8868\u8fbe\u6c34\u5e73\uff0cMPO \u57fa\u56e0\u7f16\u7801\u4e86\u4e00\u79cd\u5e7f\u6cdb\u4f7f\u7528\u7684 APL \u8bca\u65ad\u6807\u5fd7\u7269\uff0c\u800c\u4e14\u4e5f\u4e0d\u540c\u4e8e\u6b63\u5e38\u7684\u9020\u8840\u7ec6\u80de\u7fa4\uff08\u5982 HSPCs \u548c\u9ad3\u6837\u7ec6\u80de\u7fa4\uff1b\u56fe 1b, c\uff09\u3002APL \u7ec6\u80de\u7684\u65e2\u5b9a\u6807\u5fd7\u7269\u5728\u8be5\u7ec6\u80de\u7fa4\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0cPML\/RAR\u03b1 \u76f8\u5173\u8d85\u7ea7\u589e\u5f3a\u5b50\u6fc0\u6d3b\u7684\u57fa\u56e0\uff08\u5982 STAB1\u3001CITED2\u3001CCND2 \u548c GFI1\uff09\u4e5f\u7a81\u51fa\u663e\u793a\u4e86\u8fd9\u4e00\u70b9\uff08\u56fe 1d\uff09\u3002\u6b64\u5916\uff0c\u8be5\u7ec6\u80de\u7fa4\u7684 GMP \u7279\u5f02\u6027\u57fa\u56e0\uff0c\u5982\u55dc\u6c2e\u9897\u7c92\u57fa\u56e0\uff08MPO\u3001AZU1\u3001ELANE \u548c CTSG\uff09\u7684\u8868\u8fbe\u6c34\u5e73\u660e\u663e\u5347\u9ad8\uff08\u56fe 1d\uff09\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\">   <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u63a5\u7740\u6bd4\u8f83\u4e86 APL \u7ec6\u80de\u7fa4\u4e0e\u6b63\u5e38 GMP \u7ec6\u80de\u7fa4\u7684\u529f\u80fd\u548c\u8c03\u63a7\u7279\u5f81\u3002\u9996\u5148\uff0c\u5bf9\u4f7f\u7528 Seurat \u8ba1\u7b97\u7684\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\uff08DEGs\uff09\u8fdb\u884c\u4e86GO\u5bcc\u96c6\u5206\u6790\u3002\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0cAPL\u80da\u80ce\u4e2d\u660e\u663e\u4e0a\u8c03\u7684\u57fa\u56e0\u4e0e\u51e0\u4e2a\u5173\u952e\u8fc7\u7a0b\u5177\u6709\u529f\u80fd\u76f8\u5173\u6027\uff0c\u5305\u62ec\u9020\u8840\u5e72\u7ec6\u80de\u81ea\u6211\u66f4\u65b0\/\u5206\u5316\u3001\u7ec4\u86cb\u767d\u4fee\u9970\u548c DNA \u7532\u57fa\u5316\u3001\u7ec6\u80de\u5468\u671f\u505c\u6ede\u548c\u7ec6\u80de\u751f\u957f\uff0c\u4ee5\u53ca\u5bf9\u5185\u8d28\u7f51\u5e94\u6fc0\u548c\u672a\u6298\u53e0\u86cb\u767d\u7684\u53cd\u5e94\uff08\u56fe 1e\uff09\u3002\u4e0e\u6b64\u76f8\u53cd\uff0c\u5728 APL \u7ec6\u80de\u4e2d\u660e\u663e\u4e0b\u8c03\u7684\u57fa\u56e0\u7684\u57fa\u56e0\u5bcc\u542b\u514d\u75ab\u53cd\u5e94\u76f8\u5173\u529f\u80fd\uff0c\u5305\u62ec\u6297\u539f\u5904\u7406\u548c\u5448\u9012\u3001MHC II \u7c7b\u86cb\u767d\u590d\u5408\u7269\u3001\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u8c03\u63a7\u4ee5\u53ca\u5bf9\u5e72\u6270\u7d20-\u03b3 \u7684\u53cd\u5e94\uff08\u56fe 1f\uff09\u3002\u8fd9\u4e9b\u53d1\u73b0\u8bc1\u5b9e\u4e86 APL \u7ec6\u80de\u7684\u6297\u539f\u9012\u5448\u4e2d\u65ad\u3002\u5176\u6b21\uff0c\u4f7f\u7528 VIPER \u63a8\u65ad\u4e86\u4e24\u4e2a\u7ec6\u80de\u7fa4\u4e4b\u95f4\u4e0d\u540c\u7684\u8f6c\u5f55\u56e0\u5b50\uff08TF\uff09\u6d3b\u6027\u3002\u5206\u6790\u8868\u660e\uff0c\u9020\u8840 TF \u548c\u8f85\u52a9\u56e0\u5b50\u5728 APL \u7ec6\u80de\u4e2d\u53d7\u5230\u6291\u5236\uff08\u56fe 1g\uff09\uff0c\u652f\u6301\u4e86\u5728 APL \u7ec6\u80de\u4e2d\u89c2\u5bdf\u5230\u7684\u5206\u5316\u53d7\u963b\u3002\u6b64\u5916\uff0c\u5e72\u6270\u7d20\uff08IFN\uff09\u4fe1\u53f7\u8f6c\u5bfc\u4ecb\u8d28\u4e5f\u5728 APL \u7ec6\u80de\u4e2d\u53d7\u5230\u6291\u5236\u3002\u76f8\u53cd\uff0c\u4e0e\u6b63\u5e38 GMPs \u76f8\u6bd4\uff0c\u81f4\u764c TFs\u3001\u8868\u89c2\u9057\u4f20\u8c03\u8282\u56e0\u5b50\u548c\u7ec6\u80de\u589e\u6b96\u76f8\u5173 TFs\u5728 APL \u75c5\u7076\u4e2d\u88ab\u6fc0\u6d3b\uff08\u56fe 1g\uff09\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\">   <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009646\" data-ratio=\"1.3277777777777777\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_N5ytzswSEibalPKibSsjZwRz7VdEzA-4.jpg?resize=551%2C707\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx5w20Uia6K384SRvofkPy5fku76rR5S6b8sAunjjhzUbbbcicUgN5ytzswSEibalPKibSsjZwRz7VdEzA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" height=\"707 .47998046875\" width=\"551 .010009765625\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe1 \u901a\u8fc7\u7efc\u5408\u5206\u6790 APL \u548c\u6b63\u5e38\u9aa8\u9ad3 (BM) \u7ec6\u80de\u7684 scRNA-seq \u6570\u636e\uff0c\u786e\u5b9a APL \u539f\u59cb\u7ec6\u80de\u7684\u7279\u5f81<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\">2. \u8868\u5f81APL\u539f\u59cb\u7ec6\u80de\u7684\u7624\u5185\u5f02\u8d28\u6027\u63ed\u793a\u4e86\u590d\u6742\u7684\u7ec6\u80de\u72b6\u6001\u8f6c\u53d8\u8f68\u8ff9\uff0c\u767d\u8840\u75c5\u5e72\u6837\u7ec6\u80de\u4f4d\u4e8e\u9876\u7aef<\/span><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u63a5\u4e0b\u6765\uff0c\u786e\u5b9a\u4e86APL\u539f\u59cb\u7ec6\u80de\u5185\u7684\u7ec6\u80de\u7ed3\u6784\u548c\u5206\u5316\u8f68\u8ff9\u3002\u901a\u8fc7\u65e0\u76d1\u7763\u805a\u7c7b\u548c UMAP \u5206\u6790\uff0c\u786e\u5b9a\u4e86 18 \u4e2a\u805a\u7c7b\uff0c\u6bcf\u4e2a\u805a\u7c7b\u90fd\u4ee5\u5df2\u77e5\u6807\u8bb0\u57fa\u56e0\u7684\u4e0d\u540c\u8868\u8fbe\u6a21\u5f0f\u4e3a\u7279\u5f81\uff08\u56fe 2a\uff09\u3002\u5728\u8fd9\u4e9b\u805a\u7c7b\u4e2d\uff0c12 \u4e2a APL \u4e9a\u7fa4\uff08C1-C12\uff09\u5360\u7ec6\u80de\u603b\u6570\u7684 82.9%\uff0c\u8868\u73b0\u51fa GMP \u7279\u5f02\u6027\u57fa\u56e0\u7684\u9ad8\u8868\u8fbe\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u4e0e\u55dc\u6c2e\u9897\u7c92\u76f8\u5173\u7684\u57fa\u56e0\uff08\u56fe 2b\uff09\u3002\u8fd9\u4e9bGMP\u6837\u4e9a\u7fa4\u663e\u793a\u51fa\u660e\u663e\u7684\u5f02\u8d28\u6027\u3002\u4f8b\u5982\uff0cC1-C3 \u4e9a\u7fa4\u53ea\u8868\u8fbe GMP \u7279\u5f02\u6027\u57fa\u56e0\uff0c\u800c C6-C10 \u4e9a\u7fa4\u5219\u9ad8\u8868\u8fbe\u7ec6\u80de\u589e\u6b96\u76f8\u5173\u57fa\u56e0\uff0cC11-C12 \u4e9a\u7fa4\u5219\u9ad8\u8868\u8fbe S100 \u5bb6\u65cf\u57fa\u56e0\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u63a5\u4e0b\u6765\uff0c\u8fdb\u884c\u4e86RNA\u901f\u5ea6\u5206\u6790\uff0c\u4ee5\u9a8c\u8bc1\u4ece\u767d\u8840\u75c5\u5e72\u6837\u7ec6\u80de\u7fa4\uff08C15\uff09\u5230GMP\u6837\u7ec6\u80de\u7fa4\u7684\u5206\u5316\u8f68\u8ff9\u3002\u6839\u636e\u57fa\u4e8e\u901f\u5ea6\u7684\u7ec6\u80de\u72b6\u6001\u8f6c\u6362\u6982\u7387\u548c\u8868\u8fbe\u6a21\u5f0f\u7684\u76f8\u4f3c\u6027\uff08\u56fe 2c\u3001d\uff09\uff0c18 \u4e2a APL \u4e9a\u7fa4\u91cd\u7ec4\u4e3a\u516d\u4e2a\u5206\u652f\uff0c\u5e72\u6837\u7ec6\u80de\u4e9a\u7fa4\uff08C15\uff09\u4f4d\u4e8e\u5206\u5316\u8f68\u8ff9\u7684\u6839\u90e8\u3002\u5e72\u6837\u7ec6\u80de\u4e9a\u7fa4\uff08C15\uff09\u5f88\u53ef\u80fd\u7ecf\u8fc7Prog\u6837 \u5206\u652f\uff08C14\uff09\uff0c\u4ea7\u751f\u4e86 APL \u539f\u59cb\u7ec6\u80de\u7684\u4e09\u4e2a\u4e3b\u8981\u5206\u652f\uff1aGMP \u6837\u5206\u652f\uff08C1-C5 \u548c C13\uff09\u3001\u5faa\u73af GMP \u6837\u5206\u652f\uff08C6-C10\uff09\u548c S100\u9ad8\u8868\u8fbeGMP \u6837\u5206\u652f\uff08C11 \u548c C12\uff09\uff08\u56fe 2c\u3001d\uff09\u3002\u4ece C15 \u5f00\u59cb\u7684\u53e6\u4e00\u6761\u8f68\u8ff9\u901a\u5411 MDP \u6837\u7ec6\u80de\u7fa4\uff08C16\uff09\uff0c\u968f\u540e\u5206\u5316\u6210 CD1C+ PrecDC \u6837\u7ec6\u80de\u7fa4\uff08C17\uff09\u548c CD14+ \u539f\u5355\u6838\u7ec6\u80de\u6837\u4e9a\u7fa4\uff08C18\uff09\u3002\u8fd9\u4e00\u8f68\u8ff9\u652f\u6301\u4e86\u76ee\u524d\u7684\u89c2\u70b9\uff0c\u5373 MDPs \u53ef\u80fd\u4ee3\u8868\u4e86\u66f4\u65e9\u7684\u9636\u6bb5\uff0c\u751a\u81f3\u53ef\u80fd\u65e9\u4e8e CMP \u9636\u6bb5\uff0c\u800c\u4e0d\u662f\u6e90\u81ea GMPs\u3002\u6b64\u5916\uff0cMonocle2\u4f2a\u65f6\u95f4\u6392\u5e8f\u8f68\u8ff9\u5206\u6790\u8fd8\u663e\u793a\uff0c\u5e72\u6837\u7ec6\u80de\u7fa4\u662fAPL\u539f\u59cb\u7ec6\u80de\u7684\u8d77\u70b9\uff0c\u4ea7\u751f\u4e86S100\u9ad8\u8868\u8fbeGMP\u6837\u548cGMP\u6837\u5206\u652f\uff08\u56fe2e\uff09\u3002\u8be5\u5206\u6790\u8fd8\u663e\u793a\uff0cRUNX1\u3001RUNX2\u548c\u5e72\u6270\u7d20\u76f8\u5173\u56e0\u5b50\u53ef\u80fd\u53c2\u4e0e\u4e86GMP\u6837\u5206\u5316\u8f68\u8ff9\uff0c\u800cCEBP\u5bb6\u65cf\u6210\u5458\u3001MAFB\u3001JUNB\u548cJUND\u53ef\u80fd\u4e0eS100\u9ad8\u8868\u8fbeGMP\u6837APL\u539f\u59cb\u7ec6\u80de\u7684\u7cfb\u8c31\u51b3\u5b9a\u6709\u5173\uff08\u56fe2f\uff09\u3002<\/span>  <\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"> <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u6b64\u5916\uff0c\u8fd8\u7814\u7a76\u4e86 PML\/RAR\u03b1 \u5728\u5df2\u786e\u5b9a\u7684 APL \u8f68\u8ff9\u4e2d\u7684\u4f5c\u7528\u3002PML\/RAR\u03b1\u9776\u5411scRNA-seq\u8bc1\u5b9e\uff0cPML\/RAR\u03b1\u5728APL\u539f\u59cb\u7ec6\u80de\u7684\u6240\u6709\u516d\u4e2a\u5206\u652f\u4e2d\u5747\u5300\u8868\u8fbe\uff0c\u5728\u5e72\u6837\u7ec6\u80de\u96c6\u7fa4\u4e2d\u8868\u8fbe\u663e\u8457\uff08\u56fe2g\u3001h\uff09\u3002\u6b64\u5916\uff0c\u6574\u5408\u4e86\u4ece APL \u60a3\u8005\u884d\u751f\u7ec6\u80de\u7cfb NB4 \u7684 CUT&Tag-seq\u4e2d\u83b7\u5f97\u7684 PML\/RAR\u03b1 \u67d3\u8272\u8d28\u5360\u4f4d\u6570\u636e\u3002\u6bcf\u4e2a\u5206\u652f\u90fd\u6709\u76f8\u5f53\u591a\u4e0d\u540c\u7684 PML\/RAR\u03b1 \u9776\u70b9\uff08\u56fe 2i\uff09\uff0c\u8fd9\u8868\u660e\u5728\u6574\u4e2a APL \u8f68\u8ff9\u4e2d\uff0cPML\/RAR\u03b1 \u9776\u70b9\u5b58\u5728\u5206\u652f\u7279\u5f02\u6027\u8868\u8fbe\u6a21\u5f0f\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009649\" data-ratio=\"1.3277777777777777\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_37cWbIxRpgeU10xocu33BBzDDgUSMQ-4.jpg?resize=560%2C644\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx5w20Uia6K384SRvofkPy5fkVSj9p1BbaAra0R3A3jicR6Xibx37cWbIxRpgeU10xocu33BBzDDgUSMQ\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" height=\"644 .1400146484375\" width=\"560 .47998046875\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe2 APL \u539f\u59cb\u7ec6\u80de\u7624\u5185\u5f02\u8d28\u6027\u7684\u7279\u5f81\u63ed\u793a\u4e86\u4e00\u4e2a\u5177\u6709\u591a\u4e2a\u5206\u652f\u548c\u5c11\u91cf APL \u5e72\u6837\u7ec6\u80de\u4e9a\u7fa4\u7684\u590d\u6742\u8f68\u8ff9<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\">3. PML\/RAR\u03b1\u9776\u57fa\u56e0\u51b3\u5b9a\u4e86APL\u5e72\u6837\u7ec6\u80de\u7684\u7279\u5f81\uff0cFLT3-ITD\u5219\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e86\u5176\u7279\u5f81<\/span><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u4e3a\u4e86\u6df1\u5165\u7814\u7a76\u5b9a\u4e49\u7684APL\u5e72\u6837\u7ec6\u80de\u7684\u7279\u5f81\uff0c\u901a\u8fc7\u6bd4\u8f83\u56fe2a\u4e2dAPL\u5e72\u6837\u7ec6\u80de\u7fa4\uff08C15\uff09\u548c\u56fe1b\u4e2dHSPC\u7fa4\u7684\u8f6c\u5f55\u7ec4\u6570\u636e\uff0c\u786e\u5b9a\u4e86APL\u7279\u5f02\u6027\u767d\u8840\u75c5\u5e72\u6027\u57fa\u56e0\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u9996\u5148\uff0cPML\/RAR\u03b1\u9776\u6807\u660e\u663e\u5bcc\u96c6\u5728\u8fd9\u4e9bAPL\u7279\u5f02\u6027\u767d\u8840\u75c5\u5e72\u6027\u57fa\u56e0\u4e2d\uff08\u56fe3a\uff09\u3002LSC\u6807\u8bb0\u57fa\u56e0\u53ea\u5728APL\u5e72\u6837\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u800c\u4e0d\u5728HSPC\u4e2d\u8868\u8fbe\u3002\u5b83\u4eec\u4e5f\u662fPML\/RAR\u03b1\u7684\u76f4\u63a5\u9776\u6807\uff08\u56fe3b\uff09\u3002\u6b64\u5916\uff0c\u5e72\u6027\/\u81ea\u6211\u66f4\u65b0\u76f8\u5173\u7684PML\/RAR\u03b1\u9776\u6807\uff0c\u5728APL\u5e72\u6837\u7ec6\u80de\u4e2d\u9ad8\u5ea6\u8868\u8fbe\u3002\u4e0eAPL\u767d\u8840\u75c5\u53d1\u751f\u5bc6\u5207\u76f8\u5173\u7684\u57fa\u56e0\uff0c\u5982FLT3\u548cJAG1\uff0c\u4e0d\u4ec5\u662fPML\/RAR\u03b1\u7684\u9776\u6807\uff0c\u800c\u4e14\u5728APL\u5e72\u6837\u7ec6\u80de\u4e2d\u4e5f\u6709\u9ad8\u8868\u8fbe\uff08\u56fe3b\uff09\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u5176\u6b21\uff0c\u8fdb\u884c\u4e86\u901a\u8def\u5bcc\u96c6\u5206\u6790\uff0c\u4ee5\u63ed\u793aPML\/RAR\u03b1\u5931\u8c03\u4fe1\u53f7\u901a\u8def\u53c2\u4e0eAPL\u5e72\u6837\u7ec6\u80de\u7684\u60c5\u51b5\u3002\u8fd9\u9879\u5206\u6790\u786e\u5b9a\u4e86\u8bb8\u591a\u4e0eLSC\u76f8\u5173\u7684\u901a\u8def\uff0c\u5305\u62ec\u7ecf\u5178\u7684WNT\u3001MAPK\u3001VEGF\u3001P53\u548cmTOR\u4fe1\u53f7\uff08\u56fe3c\uff09\uff0c\u5b83\u4eec\u90fd\u5bf9\u7ef4\u6301LSC\u7fa4\u81f3\u5173\u91cd\u8981\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u7b2c\u4e09\uff0c\u8fdb\u884c\u4e86VIPER\u5206\u6790\uff0c\u4ee5\u9610\u660e\u53c2\u4e0ePML\/RAR\u03b1\u8bf1\u5bfc\u7684APL\u5e72\u6837\u7ec6\u80de\u8f6c\u5f55\u7f51\u7edc\u7684\u6f5c\u5728TFs\uff08\u56fe3d\uff09\u3002\u901a\u8fc7\u4e0e\u6b63\u5e38HSPCs\u6bd4\u8f83\uff0c\u53d1\u73b0\u4e0e\u5e72\u6027\u76f8\u5173\u7684TFs\u88ab\u6fc0\u6d3b\uff0c\u8fd9\u8868\u660e\u5b83\u4eec\u5728\u8c03\u8282APL\u7ec6\u80de\u7684\u5e72\u6027\u4e2d\u53ef\u80fd\u53d1\u6325\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u5728APL\u5e72\u6837\u7ec6\u80de\u4e2d\uff0c\u89c2\u5bdf\u5230\u4e0e\u7ec4\u86cb\u767d\u4fee\u9970\u76f8\u5173\u7684\u8c03\u8282\u56e0\u5b50\u88ab\u6fc0\u6d3b\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u5b83\u4eec\u53ef\u80fd\u53c2\u4e0e\u4e86 APL \u5e72\u6837\u7ec6\u80de\u81ea\u6211\u66f4\u65b0\u548c\u9759\u6b62\u7684\u8868\u89c2\u9057\u4f20\u63a7\u5236\u3002\u4e0e\u6076\u6027\u8f6c\u5316\u548c\u5e72\u6027\u7279\u6027\u76f8\u5173\u7684TFs\uff0c\u4e5f\u88ab\u53d1\u73b0\u5728APL\u5e72\u6837\u7ec6\u80de\u4e2d\u6d3b\u8dc3\u3002\u8fd9\u4e9b\u53d1\u73b0\u51f8\u663e\u4e86PML\/RAR\u03b1\u5728\u5355\u7ec6\u80de\u6c34\u5e73\u4e0a\u8c03\u63a7APL\u5e72\u6837\u7ec6\u80de\u7684\u5173\u952e\u4f5c\u7528\u3002<\/span> <\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\">   <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u7b2c\u56db\uff0c\u7ee7\u7eed\u5c06APL\u539f\u59cb\u7ec6\u80de\u7684\u7ec6\u80de\u7ed3\u6784\u4e0eAPL\u4e2d\u5e38\u89c1\u7684\u5408\u4f5c\u57fa\u56e0\u6539\u53d8\u8054\u7cfb\u8d77\u6765\u3002\u5982\u56fe3e\u6240\u793a\uff0c\u4e0e\u5176\u4ed6\u7814\u7a76\u7684\u7a81\u53d8\u76f8\u6bd4\uff0cFLT3-ITD\u4e0e\u66f4\u539f\u59cb\u7684\u75be\u75c5\u8868\u578b\u660e\u663e\u76f8\u5173\uff0c\u8fd9\u8868\u660eFLT3-ITD\u7684\u5b58\u5728\u53ef\u80fd\u5728\u589e\u5f3a\u767d\u8840\u75c5\u5e72\u6027\u65b9\u9762\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u8fdb\u4e00\u6b65\u4f7f\u7528\u4e24\u79cd\u5df2\u5efa\u7acb\u7684\u767d\u8840\u75c5\u5e72\u6027\u8bc4\u5206\uff0c\u5373LSC17\u548cLSC6\uff0c\u6765\u6bd4\u8f83\u6709FLT3-ITD\u548c\u65e0FLT3-ITD\u7684APL\u5e72\u6837\u7ec6\u80de\u7684\u5e72\u6027\u7279\u5f81\u3002\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u6709FLT3-ITD\u7684\u5e72\u6837\u7ec6\u80de\u5f97\u5206\u660e\u663e\u9ad8\u4e8e\u65e0FLT3-ITD\u7684\u5e72\u6837\u7ec6\u80de\uff08\u56fe3f\uff09\uff0c\u652f\u6301\u4e86FLT3-ITD\u53ef\u80fd\u589e\u5f3a\u5e72\u6027\u7279\u5f81\u7684\u89c2\u70b9\u3002\u6b64\u5916\uff0c\u5728\u4e24\u540dAPL\u60a3\u8005\u4e2d\u8fdb\u884c\u4e86FLT3-ITD\u9776\u5411scRNA-seq\u7814\u7a76\uff0c\u8bc1\u5b9e\u4e86\u5176\u5728APL\u5e72\u6837\u7ec6\u80de\u4e2d\u7684\u9ad8\u8868\u8fbe\uff08\u56fe3g\u3001h\uff09\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\">   <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009647\" data-ratio=\"1.3277777777777777\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_eUjvmPQiaHadSDjUib6KicoqSiaTgw-4.jpg?resize=545%2C581\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx5w20Uia6K384SRvofkPy5fkvjYL5hAvzbOXgat3vChhibfwgf4YFeUjvmPQiaHadSDjUib6KicoqSiaTgw\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" height=\"581 .340087890625\" width=\"545 .8800048828125\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe3 PML\/RAR\u03b1\u548cFLT3-ITD\u5728\u8c03\u8282APL\u5e72\u6837\u7ec6\u80de\u7279\u6027\u4e2d\u7684\u5173\u952e\u4f5c\u7528<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\">4. APL\u5e72\u6027\u8bc4\u5206\u5bf9APL\u65e9\u671f\u6b7b\u4ea1\u548c\u6cbb\u7597\u7ed3\u679c\u7684\u9884\u6d4b\u80fd\u529b<\/span><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u63a5\u7740\u63a2\u8ba8\u4e86\u5982\u4f55\u5229\u7528scRNA-seq\u5b9a\u4e49\u7684APL\u5e72\u6837\u7ec6\u80de\u6765\u9884\u6d4bAPL\u7684\u4e34\u5e8a\u969c\u788d\uff0c\u5373\u65e9\u671f\u6b7b\u4ea1\u7684\u53d1\u751f\u3001\u98ce\u9669\u5206\u5c42\u548c\u6cbb\u7597\u7ed3\u679c\u3002\u9996\u5148\u5efa\u7acb\u4e86\u57fa\u4e8e\u89e3\u5377\u79ef\u7684\u9884\u6d4b\u7a0b\u5e8f\uff08\u56fe 4a\uff09\uff0c\u5e76\u8bc1\u660e\u4e86\u5176\u7a33\u5065\u6027\u548c\u6027\u80fd\uff08\u56fe 4b\uff09\u3002\u5728\u6b65\u9aa4 1 \u4e2d\uff0c\u5c06 CIBERSORTx \u7b97\u6cd5 \u5e94\u7528\u4e8e scRNA-seq \u6570\u636e\uff0c\u751f\u6210\u4e86 APL \u7279\u5f02\u6027\u7279\u5f81\u77e9\u9635\uff0c\u5176\u4e2d\u6d89\u53ca 6 \u4e2a APL \u539f\u59cb\u7ec6\u80de\u7fa4\uff08\u5373\u5e72\u6837\u7ec6\u80de\u3001Prog \u6837\u7ec6\u80de\u3001GMP \u6837\u7ec6\u80de\u3001\u5faa\u73af GMP \u6837\u7ec6\u80de\u3001S100\u9ad8\u8868\u8fbeGMP \u6837\u7ec6\u80de\u548c MDP \u6837\u7ec6\u80de\uff09\u548c 3 \u4e2a\u975e\u767d\u8840\u75c5\u7ec6\u80de\u7c7b\u578b\uff08\u5373 T\/NK\u3001B \u548c\u7ea2\u7ec6\u80de\uff09\u3002\u7b2c\u4e8c\u6b65\uff0c\u4ecebulk RNA-seq \u6570\u636e\u4e2d\u51c6\u5907\u4e86\u5916\u663e\u5b50\u6a21\u578b\u6bcf\u767e\u4e07\u6620\u5c04\u8bfb\u6570\uff08TPM\uff09\u7684\u6bcf\u5343\u78b1\u57fa\u8f6c\u5f55\u672c\u77e9\u9635\u3002\u7b2c\u4e09\u6b65\uff0c\u91c7\u7528\u652f\u6301\u5411\u91cf\u56de\u5f52\uff08SVR\uff09 \u5bf9\u7279\u5f81\u77e9\u9635\u548c TPM \u77e9\u9635\u8fdb\u884c\u89e3\u65cb\uff0c\u5f97\u51fa\u7cfb\u6570\u77e9\u9635\u3002\u7cfb\u6570\u77e9\u9635\u4e2d\u6bcf\u79cd\u7ec6\u80de\u7c7b\u578b\u6240\u5360\u7684\u767e\u5206\u6bd4\u7528\u4e8e\u5efa\u7acb\u7ebf\u6027\u56de\u5f52\u6a21\u578b\uff0c\u4ee5\u8fdb\u884c\u57fa\u51c6\u6d4b\u8bd5\u3002\u5728\u6b65\u9aa4 4 \u4e2d\uff0c\u901a\u8fc7 LASSO \u5efa\u7acb\u4e86\u4e00\u4e2a 11 \u57fa\u56e0\u8bc4\u5206\u6a21\u578b\uff0c\u4ee5\u8bc4\u4f30\u5927\u91cf RNA-seq \u6570\u636e\u4e2d APL \u539f\u59cb\u7ec6\u80de\u7684\u5e72\u6027\uff0c\u5f97\u5206\u8d8a\u9ad8\u8868\u793a\u5e72\u6027\u8d8a\u5f3a\u3002\u6b64\u5916\uff0c\u8fd8\u8bbe\u8ba1\u4e86\u4e00\u4e2a\u7559\u4e00\u68c0\u9a8c\uff0c\u4ee5\u8bc1\u660e\u63a8\u65ad\u51fa\u7684APL\u5e72\u6837\u7ec6\u80de\u6bd4\u4f8b\u7684\u7a33\u5065\u6027\uff08\u56fe4b\uff09\u3002\u603b\u4e4b\uff0c\u8be5\u53bb\u5377\u79ef\u65b9\u6cd5\u53ef\u4ee5\u4ece\u5927\u91cfAPL\u8f6c\u5f55\u7ec4\u4e2d\u51c6\u786e\u9884\u6d4bAPL\u5e72\u6837\u7ec6\u80de\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\">   <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u63a5\u4e0b\u6765\uff0c\u5229\u7528\u5df2\u5efa\u7acb\u7684\u89e3\u5377\u79ef\u9884\u6d4b\u7a0b\u5e8f\uff0c\u7814\u7a76\u4e86\u7531323\u540dAPL\u60a3\u800553\u7ec4\u6210\u7684\u5927\u578b\u961f\u5217\uff0c\u63a2\u8ba8APL\u5e72\u6837\u7ec6\u80de\u4e0eAPL\u60a3\u8005\u4e34\u5e8a\u7279\u5f81\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002\u9996\u5148\uff0c\u8f83\u9ad8\u6bd4\u4f8b\u7684APL\u5e72\u6837\u7ec6\u80de\u4e0e\u767d\u7ec6\u80de\uff08WBC\uff09\u8ba1\u6570\u5347\u9ad8\u548c\u8840\u5c0f\u677f\u8ba1\u6570\u964d\u4f4e\u663e\u8457\u76f8\u5173\uff08\u56fe5a\uff09\u3002\u7ed3\u679c\u8868\u660e\uff0cAPL\u60a3\u8005\u7684APL\u539f\u59cb\u7ec6\u80de\u4e2dAPL\u5e72\u6837\u7ec6\u80de\u6bd4\u4f8b\u8f83\u9ad8\uff0c\u53ef\u80fd\u4f1a\u589e\u52a0\u5916\u5468\u8840\u4e2d\u5faa\u73af\u7684\u503e\u5411\u3002\u5176\u6b21\uff0c\u7814\u7a76\u4e86APL\u5e72\u6837\u7ec6\u80de\u6bd4\u4f8b\u4e0eAPL\u60a3\u8005\u590d\u53d1\u6027\u7a81\u53d8\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u8f83\u9ad8\u6bd4\u4f8b\u7684 APL \u5e72\u6837\u7ec6\u80de\u4e0e S \u578b PML\/RAR\u03b1 \u8f6c\u5f55\u672c\u548c FLT3-ITD\u660e\u663e\u76f8\u5173\uff08\u56fe 5a\uff09\u3002\u6b64\u5916\uff0cFLT3-ITD\u88ab\u786e\u5b9a\u4e3a\u6700\u91cd\u8981\u7684\u5171\u73b0\u4e8b\u4ef6\uff0c\u652f\u6301\u4e86FLT3-ITD\u5728\u589e\u5f3aAPL\u5e72\u6837\u7ec6\u80de\u5e72\u6027\u6d3b\u6027\u65b9\u9762\u7684\u91cd\u8981\u6027\uff08\u56fe3f\uff09\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u9274\u4e8eAPL\u5e72\u6837\u7ec6\u80de\u4e0e\u6f5c\u5728\u7684\u4e0d\u5229\u9884\u540e\u56e0\u7d20\u5bc6\u5207\u76f8\u5173\uff0c\u8bd5\u56fe\u5f00\u53d1\u4e00\u79cd\u4e13\u4e3aAPL\u539f\u59cb\u7ec6\u80de\u5b9a\u5236\u7684\u5e72\u6027\u8bc4\u5206\u7cfb\u7edf\u3002\u91c7\u7528LASSO\u7b97\u6cd5\uff0c\u6839\u636eAPL\u5e72\u6837\u7ec6\u80de\u7684\u4f30\u8ba1\u7ec6\u80de\u6bd4\u4f8b\u5efa\u7acb\u4e86APL\u7279\u5f02\u6027\u5e72\u6027\u8bc4\u5206\uff0c\u7136\u540e\u5229\u7528\u8be5\u8bc4\u5206\u91cf\u5316\u6bcf\u4f4d\u60a3\u8005\u767d\u8840\u75c5\u7ec6\u80de\u7684\u5e72\u6027\u3002\u786e\u5b9a\u4e8611\u4e2a\u57fa\u56e0\u6765\u6784\u5efaAPL\u5e72\u6027\u8bc4\u5206\uff0c\u8be5\u8bc4\u5206\u4e0eAPL\u5e72\u6837\u7ec6\u80de\u7684\u6bd4\u4f8b\u6709\u663e\u8457\u76f8\u5173\u6027\u3002\u7136\u540e\uff0c\u63a2\u8ba8\u4e86APL\u5e72\u6027\u8bc4\u5206\u4e0e\u9884\u540e\u7684\u5173\u7cfb\u3002\u9ad8APL\u5e72\u6027\u8bc4\u5206\u4e0e\u8f83\u5dee\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u548c\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f(EFS)\u663e\u8457\u76f8\u5173\uff0c\u4f46\u4e0e\u65e0\u75be\u75c5\u751f\u5b58\u671f\u65e0\u5173\uff08\u56fe5b\uff09\u3002\u5355\u53d8\u91cfCox\u5206\u6790\u8fd8\u663e\u793a\uff0cAPL\u5e72\u6027\u8bc4\u5206\u8f83\u9ad8\u7684\u60a3\u8005\u9884\u540e\u8f83\u5dee\uff0c\u8fd9\u53cd\u6620\u5728OS\uff08\u56fe5c\uff09\u548cEFS\uff08\u56fe5d\uff09\u3002APL\u5e72\u6027\u8bc4\u5206\u8d8a\u9ad8\uff0c\u65e9\u671f\u6b7b\u4ea1\u98ce\u9669\u8d8a\u9ad8\uff08\u56fe5b\uff09\u3002\u7ed3\u679c\u5f3a\u8c03\u4e86APL\u5e72\u6027\u8bc4\u5206\u5728\u8bc4\u4f30APL\u98ce\u9669\u65b9\u9762\u7684\u5b9e\u7528\u6027\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\">   <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009650\" data-ratio=\"1.3277777777777777\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_k17aXKwWLLrticfSbzL9RoUOSRLKsQ-4.jpg?resize=553%2C217\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx5w20Uia6K384SRvofkPy5fk5ibSPZEAxSuLhbYCQx8SfPtl3Pk17aXKwWLLrticfSbzL9RoUOSRLKsQ\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" height=\"217 .94000244140625\" width=\"553 .3400268554688\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe4 \u6784\u5efa11\u4e2a\u57fa\u56e0\u7684APL\u5e72\u6027\u8bc4\u5206<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009651\" data-ratio=\"1.3277777777777777\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_QRaiaogcTgB6BF27XUYtNSSH6Zsepg-4.jpg?resize=547%2C392\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx5w20Uia6K384SRvofkPy5fkpMLMND5iauLNHVt9JH6j2fwjczQRaiaogcTgB6BF27XUYtNSSH6Zsepg\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" height=\"392 .66998291015625\" width=\"547 .4099731445312\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe5 APL \u5e72\u6027\u8bc4\u5206\u5728\u9884\u6d4b APL \u9884\u540e\u548c\u65e9\u671f\u6b7b\u4ea1\u65b9\u9762\u7684\u4fe1\u606f\u6027<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\">   <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\">5. ATRA \u5bf9\u539f\u59cb APL \u7ec6\u80de\u5206\u5316\u7684\u4f53\u5185\u6548\u5e94\u53ca\u5176\u5bf9\u65e9\u671f\u6b7b\u4ea1\u98ce\u9669\u7684\u5f71\u54cd<\/span><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u5c3d\u65e9\u4f7f\u7528 ATRA \u5bf9\u964d\u4f4e APL \u65e9\u671f\u6b7b\u4ea1\u7387\u81f3\u5173\u91cd\u8981\u3002\u968f\u540e\uff0c\u8fdb\u4e00\u6b65\u63a2\u8ba8\u4e86ATRA\u6cbb\u7597\u5bf9APL\u7ec6\u80de\u5206\u7ea7\u7684\u4f53\u5185\u5f71\u54cd\uff0c\u5c24\u5176\u5173\u6ce8\u539f\u59cb\u7ec6\u80de\uff0c\u56e0\u4e3a\u5b83\u4eec\u7684\u5e72\u6027\u53ef\u80fd\u4f1a\u5f71\u54cd\u6cbb\u7597\u53cd\u5e94\u3002\u5bf9ATRA\u6cbb\u7597\u4e24\u5929\u540e\u6536\u96c6\u7684\u4e09\u4f8b\u60a3\u8005\u7684\u9aa8\u9ad3\u6837\u672c\u8fdb\u884c\u4e86scRNA-seq\u5206\u6790\u3002\u9996\u5148\uff0cscRNA-seq \u6570\u636e\u7684\u5bf9\u6bd4\u5206\u6790\u663e\u793a\uff0c\u4e0e\u6cbb\u7597\u540e\u6837\u672c\u76f8\u6bd4\uff0c\u8bca\u65ad APL \u6837\u672c\u5bcc\u542b\u66f4\u591a\u539f\u59cb\u7ec6\u80de\uff0c\u800c\u6cbb\u7597\u540e\u6837\u672c\u76f8\u5bf9\u5bcc\u542b\u66f4\u591a\u6210\u719f\u7956\u7ec6\u80de\uff08\u56fe 6a\uff09\u3002\u7279\u522b\u662f\u5728\u6cbb\u7597\u540e\u7b2c2\u5929\uff0c\u6cbb\u7597\u540e\u6837\u672c\u4e2d\u51e0\u4e4e\u68c0\u6d4b\u4e0d\u5230\u5e72\u6837\u7ec6\u80de\uff08\u56fe6b\uff09\u3002ATRA\u5904\u7406\u540e\uff0c\u66f4\u6210\u719f\u7684GMP\u6837\u7ec6\u80de\u7c7b\u578b\u7684\u767e\u5206\u6bd4\u660e\u663e\u589e\u52a0\uff0c\u800c\u4e09\u79cd\u539f\u59cb\u7ec6\u80de\u7c7b\u578b\uff08\u5e72\u6837\u7ec6\u80de\u3001Prog\u6837\u7ec6\u80de\u548cS100\u9ad8\u8868\u8fbeGMP\u6837\u7ec6\u80de\uff09\u7684\u767e\u5206\u6bd4\u4e0b\u964d\uff0c\u5e72\u6837\u7ec6\u80de\u5728\u5904\u7406\u540e\u51e0\u4e4e\u68c0\u6d4b\u4e0d\u5230\uff0c\u8fd9\u8868\u660eATRA\u5bf9\u539f\u59cbAPL\u7ec6\u80de\uff0c\u5c24\u5176\u662f\u5e72\u6837\u7ec6\u80de\u6709\u660e\u663e\u7684\u5f71\u54cd\uff08\u56fe6c\u3001d\uff09\u3002\u4e3a\u4e86\u8bc1\u5b9eATRA\u80fd\u8bf1\u5bfcAPL\u539f\u59cb\u7ec6\u80de\u5411\u66f4\u6210\u719f\u7684\u7956\u7ec6\u80de\u5206\u5316\uff0c\u8fd8\u91c7\u7528\u4e86\u65e2\u5b9a\u7684\u8bc4\u5206\u65b9\u6cd5\u6765\u91cf\u5316\u767d\u8840\u75c5\u7ec6\u80de\u7684\u6210\u719f\u5ea6\uff0c\u89c2\u5bdf\u5230\u6cbb\u7597\u540e2\u5929\u7684\u6837\u672c\u4e0e\u8bca\u65ad\u65f6\u7684\u6837\u672c\u76f8\u6bd4\uff0c\u8be5\u8bc4\u5206\u663e\u8457\u589e\u52a0\uff08\u56fe6e\uff09\uff0c\u8868\u660eAPL\u7ec6\u80de\u5728ATRA\u6cbb\u7597\u540e\u53d8\u5f97\u66f4\u52a0\u6210\u719f\u3002\u901a\u8fc7\u5206\u6790 7 \u4f8b\u5728 ATRA \u6cbb\u7597\u524d\u540e\u83b7\u5f97\u5b8c\u5168\u7f13\u89e3\u7684 APL \u60a3\u8005\u7684bulk\u8f6c\u5f55\u7ec4\u4e5f\u5f97\u51fa\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002\u5982\u56fe6f\u6240\u793a\uff0cAPL\u5e72\u6837\u7ec6\u80de\u7684\u6bd4\u4f8b\u548c\u767d\u8840\u75c5\u7ec6\u80de\u7684\u5e72\u6027\u5728ATRA\u6cbb\u7597\u540e\u660e\u663e\u4e0b\u964d\uff0c\u5c24\u5176\u662f\u5728\u7b2c2\u5929\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u63a5\u4e0b\u6765\uff0c\u89c2\u5bdf\u4e86\u9020\u8840\u5206\u5316\u76f8\u5173CD\u6807\u8bb0\u7269\u548cTFs\u7684\u8868\u8fbe\u53d8\u5316\uff0c\u7ed3\u679c\u8868\u660eATRA\u53ef\u8bf1\u5bfc\u4eceAPL\u5e72\u6837\u7ec6\u80de\u5411\u66f4\u6210\u719f\u7ec6\u80de\u7684\u9010\u6b65\u5206\u5316\u3002\u5728\u539f\u59cb\u7ec6\u80de\u7c7b\u578b\u4e2d\u89c2\u5bdf\u5230APL\u5e72\u6027CD\u6807\u8bb0\u7269\u548cTFs\u7684\u663e\u8457\u4e0b\u8c03\uff08\u56fe6g\uff09\u3002\u76f8\u53cd\uff0c\u4e0e\u6210\u719f\u9020\u8840\u7ec6\u80de\u7cfb\u76f8\u5173\u7684\u6807\u8bb0\u7269\u548c TF \u5728 ATRA \u5904\u7406\u540e\u4e0a\u8c03\uff08\u56fe 6h\uff09\u3002<\/span> <\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\">   <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u5728\u6709\u65e9\u671f\u6b7b\u4ea1\u548c\u6ca1\u6709\u65e9\u671f\u6b7b\u4ea1\u7684 APL \u60a3\u8005\u4e2d\u53d1\u73b0\u4e86 ATRA \u8bf1\u5bfc\u7684\u4e0d\u540c\u8f6c\u5f55\u53cd\u5e94\u3002\u5982\u56fe6i\u6240\u793a\uff0c\u5728\u65e9\u671f\u6b7b\u4ea1\u7684APL\u60a3\u8005\u4e2d\uff0c\u672a\u89c2\u5bdf\u5230\u51e0\u79cd\u5e72\u6027\u76f8\u5173CD\u6807\u5fd7\u7269\u548cTFs\u7684\u4e00\u81f4\u4e0b\u8c03\u3002\u540c\u6837\uff0c\u5728\u65e9\u6b7b\u60a3\u8005\u4e2d\u4e5f\u672a\u89c2\u5bdf\u5230\u4e0e\u5206\u5316\u76f8\u5173\u7684CD\u6807\u8bb0\u7269\u548cTFs\u7684\u6301\u7eed\u4e0a\u8c03\uff08\u56fe6j\uff09\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cATRA\u6cbb\u7597\u5bf9\u65e9\u671f\u6b7b\u4ea1\u7684APL\u60a3\u8005\u7684\u5e72\u6027\u7a0b\u5e8f\u5f71\u54cd\u8f83\u5c0f\uff0c\u8fd9\u53ef\u80fd\u89e3\u91ca\u4e86\u89c2\u5bdf\u5230\u7684\u767d\u8840\u75c5\u7ec6\u80de\u7684\u5e72\u6027\u6d3b\u52a8\u4e0e\u65e9\u671f\u6b7b\u4ea1\u4e4b\u95f4\u7684\u663e\u8457\u5173\u8054\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009652\" data-ratio=\"1.3277777777777777\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_8AibTQV4GHoedwKpMYW3YdI6Az3gWA-4.jpg?resize=548%2C574\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx5w20Uia6K384SRvofkPy5fksK3qzhR2rvWy7wkVj8Ow9RccH8AibTQV4GHoedwKpMYW3YdI6Az3gWA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" height=\"574 .6799926757812\" width=\"548 .010009765625\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe6 \u4f53\u5185\u5206\u6790\u663e\u793a ATRA \u76f4\u63a5\u9776\u5411 APL \u539f\u59cb\u7ec6\u80de\uff08\u5305\u62ec\u5e72\u6837\u7ec6\u80de\uff09\u5e76\u8bf1\u5bfc\u5176\u5206\u5316\u548c\u6210\u719f<\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(2, 30, 170);\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(2, 30, 170);\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u8be5\u7814\u7a76\u62a5\u544a\u4e86\u5bf916\u4f8bAPL\u60a3\u8005\u8fdb\u884c\u7684\u5168\u9762\u5355\u7ec6\u80de\u5206\u6790\uff0c\u63ed\u793a\u4e86\u7ec6\u80de\u7ec4\u6210\u53ca\u5176\u5bf9\u4f53\u5185ATRA\u53cd\u5e94\u548c\u65e9\u671f\u6b7b\u4ea1\u7684\u5f71\u54cd\u3002\u63ed\u793a\u4e86\u4ee5\u767d\u8840\u75c5\u5e72\u6837\u7ec6\u80de\u4e3a\u6839\u57fa\u7684 APL \u75c5\u7076\u5185\u7684\u7ec6\u80de\u5206\u5316\u5c42\u6b21\u3002\u81f4\u764c\u7684PML\/RAR\u03b1\u878d\u5408\u86cb\u767d\u5bf9APL\u7684\u5206\u5316\u8f68\u8ff9\u5177\u6709\u7279\u5f02\u6027\u8c03\u63a7\u4f5c\u7528\u3002APL\u961f\u5217\u5206\u6790\u786e\u5b9a\u4e86\u767d\u8840\u75c5\u5e72\u7ec6\u80de\u4e0e\u767d\u7ec6\u80de\u8ba1\u6570\u5347\u9ad8\u548cFLT3-ITD\u7a81\u53d8\u4e4b\u95f4\u7684\u5173\u8054\u3002\u6b64\u5916\uff0c\u8fd8\u6784\u5efa\u4e86APL\u7279\u5f02\u6027\u5e72\u7ec6\u80de\u8bc4\u5206\uff0c\u8be5\u8bc4\u5206\u88ab\u8bc1\u660e\u53ef\u6709\u6548\u8bc4\u4f30\u65e9\u671f\u6b7b\u4ea1\u98ce\u9669\u3002\u6700\u540e\uff0c\u53d1\u73b0ATRA\u8bf1\u5bfc\u539f\u59cb\u7ec6\u80de\u5206\u5316\uff0c\u65e9\u671f\u6b7b\u4ea1\u60a3\u8005\u8868\u73b0\u51fa\u4e0d\u540c\u7684\u5e72\u7ec6\u80de\u76f8\u5173\u8f6c\u5f55\u7a0b\u5e8f\u3002\u8be5\u7814\u7a76\u5bf9APL\u7ec6\u80de\u5c42\u6b21\u7ed3\u6784\u8fdb\u884c\u4e86\u5168\u9762\u8c03\u67e5\uff0c\u4e3a\u9776\u5411\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u7684\u7ec6\u80de\u52a8\u6001\u63d0\u4f9b\u4e86\u89c1\u89e3\u3002<\/span><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\">\u6587\u7ae0\u6574\u4f53\u601d\u8def\u6e05\u6670\uff0c\u7ed3\u5408\u4e86\u591a\u7ec4\u5b66\u6570\u636e\uff0c\u4e0d\u4ec5\u6709\u81ea\u5df1\u7684\u4e00\u624b\u6570\u636e\uff0c\u8fd8\u6536\u96c6\u4e86\u591a\u7ec4\u516c\u5171\u6570\u636e\u961f\u5217\uff0c\u91c7\u7528\u4e86\u591a\u79cd\u5206\u6790\u624b\u6bb5\uff0c\u903b\u8f91\u4e25\u8c28\u53ef\u9760\uff0c\u6ca1\u6709\u5b9e\u9a8c\u7eaf\u751f\u4fe1\u7167\u6837\u62ff\u4e0b1\u533a\u9ad8\u5206\u786e\u5b9e\u4ee4\u4eba\u4f69\u670d<\/span><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\uff01\uff01<\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#0070C0;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\">\uff08ps\uff1a\u53d1\u6587\u8fd8\u7f3a\u597d\u601d\u8def\u7684\u540c\u5b66\u4eec\uff0c\u6b22\u8fce\u6765\u627e\u9986\u957f\uff0c\u8d85\u591a\u65b0\u9896\u7684\u5206\u6790\u601d\u8def\u4f9b\u4f60\u9009\u62e9\u54e6\uff01\uff09<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#0070C0;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\"><\/span><\/section>\n<section>\n<section>\n<section>\n<section>\n<section powered-by=\"xiumi.us\">\n<section>\n<section powered-by=\"xiumi.us\">\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017469\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_B2jkicacLzPjw4xMSqVvoucZjonVDA-4.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017471\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_7TvAyUibd1TPhJmZfialJtv6tu2SEg-4.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100017470\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_9N02aBaau07RufXeXRLmvAHsrFZxtw-4.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;text-wrap: wrap;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;margin-bottom: 0px;\"><br \/><\/p>\n<section><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><o:page><\/o:page><\/section>\n<p style=\"display: none;margin-bottom: 24px;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature communications\uff01\u5355\u7ec6\u80de\u7eaf\u751f\u4fe1\u8fd8\u6709\u4ec0\u4e48\u82b1\u6837\uff1f\u745e\u91d1\u533b\u9662\u8054\u5408bulk\u548cCUT& […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/50486"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=50486"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/50486\/revisions"}],"predecessor-version":[{"id":50507,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/50486\/revisions\/50507"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=50486"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=50486"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=50486"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}