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normal;\">\u53ef\u4ee5\u5e94\u7528\u5361\u65b9\u68c0\u9a8c\u6765\u9a8c\u8bc1Hardy-Weinberg\u5e73\u8861\uff0c\u628a\u8ba1\u7b97\u5f97\u5230\u7684\u57fa\u56e0\u9891\u7387\u4ee3\u5165\uff0c\u8ba1\u7b97\u57fa\u56e0\u578b\u5e73\u8861\u9891\u7387\uff0c\u518d\u4e58\u4ee5\u603b\u4eba\u6570\uff0c\u6c42\u5f97\u9884\u671f\u503c\uff08e\uff09\u3002\u628a\u89c2\u5bdf\u6570\uff08O\uff09\u4e0e\u9884\u671f\u503c\uff08E\uff09\u4f5c\u6bd4\u8f83\uff0c\u8fdb\u884c\u03c72\u68c0\u9a8c\u3002\u75c5\u4f8b\u7ec4\u548c\u5bf9\u7167\u7ec4\u7684\u57fa\u56e0\u578b\u5206\u5e03\u7684\u89c2\u5bdf\u503c\u548c\u9884\u671f\u503c\u5dee\u5f02\u65e0\u663e\u8457\u6027\uff08P>0.05\uff09\uff0c\u7b26\u5408\u9057\u4f20\u5e73\u8861\u5b9a\u5f8b:\u6bd4\u5982\u4e0b\u56fe\u4e3a\u4e00\u4e2a\u5177\u4f53\u7684Hardy-Weinberg\u9057\u4f20\u5e73\u8861\u68c0\u9a8c\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"display: flex;flex-flow: row;text-align: center;justify-content: center;margin-top: 10px;margin-bottom: 20px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPDPrt26RzZWfLn13ExG96J6ol4mDfsGWCA12FKNAmAzca1KpiaaC6pyw\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 auto;align-self: stretch;min-width: 10%;height: auto;background-color: rgb(254, 227, 229);box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(84, 54, 54);padding-right: 10px;padding-left: 10px;text-align: justify;font-size: 17px;letter-spacing: 3px;\">\n<p style=\"white-space: normal;\"><strong>\u5c0f\u56fe\u4e3e\u4f8b\u8bf4\u660e\u4e00\u4e0b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPpnvbMkq7WXX6UMv2c75MzmIH62rtwoDfxu3Tr5Nxr3B45Qwlxka2aQ\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.7121879588839941\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_IMhjf0ZuDibrAYI6mjE0NFsxX0Vhlw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPpu4dUicKXiaBOKn3QqzfVbcYI1xIMhjf0ZuDibrAYI6mjE0NFsxX0Vhlw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"681\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.4077669902912621\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_iaOLzulkibmy37GAMRSpTyLzZMOXPw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPGKSC8AYPdccw4ibjGqKCC75hiaMTiaOLzulkibmy37GAMRSpTyLzZMOXPw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"721\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.4361111111111111\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_3ul6kiaTenhDkE1VV7IYTNM1IuZ4pA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPQ2OsZ1HHEv6KjaiaXAmHS4iaFTp3ul6kiaTenhDkE1VV7IYTNM1IuZ4pA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">HO:\u89c2\u6d4b\u503c\u7b26\u5408\u57fa\u56e0\u5e73\u8861\u5b9a\u5f8b\u5206\u5e03\uff1b<\/p>\n<p style=\"white-space: normal;\">HA\uff1a\u89c2\u6d4b\u503c\u4e0d\u7b26\u5408\u57fa\u56e0\u5e73\u8861\u5b9a\u5f8b\u5206\u5e03\uff1b<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\"> MM=<span class=\"code-snippet__number\">233<\/span>;MN=<span class=\"code-snippet__number\">385<\/span>;NN=<span class=\"code-snippet__number\">129<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> pm=(MM+<span class=\"code-snippet__number\">1<\/span>\/<span class=\"code-snippet__number\">2<\/span>*MN)\/(MM+MN+NN);qn=(NN+<span class=\"code-snippet__number\">1<\/span>\/<span class=\"code-snippet__number\">2<\/span>*MN)\/(MM+MN+NN)<\/span><\/code><code><span class=\"code-snippet_outer\"> p=pm*pm;H=<span class=\"code-snippet__number\">2<\/span>*pm*qn;Q=qn*qn<\/span><\/code><code><span class=\"code-snippet_outer\"> p=c(P,H,Q)<\/span><\/code><code><span class=\"code-snippet_outer\"> data=c(MM,MN,NN)<\/span><\/code><code><span class=\"code-snippet_outer\"> chisq.test(data,p=p)<\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u7ed3\u679c\u663e\u793a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.17857142857142858\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_R5HlDjlapHEzXGbSTCHtEVYxB9NSNw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPRUgFpbQlV2Sp8XBcJMt5f6nuR5HlDjlapHEzXGbSTCHtEVYxB9NSNw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"840\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: -14px;transform: translate3d(13px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;background-color: rgb(255, 255, 255);padding-right: 15px;padding-left: 13px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;background-color: rgb(206, 233, 255);min-width: 5%;height: auto;padding: 5px 22px;\">\n<section style=\"text-align: justify;font-size: 18px;color: rgb(62, 62, 62);letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u54c8\u6e29\u5e73\u8861\u8fc7\u6ee4\u548cMAF\u8fc7\u6ee4\u7684\u533a\u522b\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;min-width: 5%;flex: 0 0 auto;height: auto;\">\n<section style=\"transform: perspective(0px);transform-style: flat;\" powered-by=\"xiumi.us\">\n<section style=\"transform: translate3d(5px, 0px, 0px) rotateX(180deg);\">\n<section style=\"display: inline-block;width: 6px;height: 6px;vertical-align: top;overflow: hidden;border-radius: 460px;background-color: rgb(244, 171, 189);\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 3px;border-color: rgb(244, 171, 189);padding: 18px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;line-height: 1.8;letter-spacing: 1.5px;\">\n<p style=\"white-space: normal;\">\u8fd9\u4e24\u4e2a\u6982\u5ff5\u4e00\u4e2a\u662f\u5bf9\u57fa\u56e0\u9891\u7387\u8fdb\u884c\u7684\u7b5b\u9009\uff0c\u4e00\u4e2a\u662f\u5bf9\u57fa\u56e0\u578b\u9891\u7387\u8fdb\u884c\u7684\u7b5b\u9009\u3002\u5bf9\u4e8e\u4e00\u4e2a\u4f4d\u70b9\u201cAA AT TT\u201d\uff0c\u5176\u4e2dA\u7684\u9891\u7387\u4e3a\u57fa\u56e0\u9891\u7387\uff0cAA\u4e3a\u57fa\u56e0\u578b\u9891\u7387\u3002MAF\u76f4\u63a5\u662f\u5bf9\u57fa\u56e0\u9891\u7387\u8fdb\u884c\u7b5b\u9009\uff0c\u800c\u54c8\u6e29\u5e73\u8861\u68c0\u9a8c\uff0c\u5219\u662f\u6839\u636e\u57fa\u56e0\u578b\u63a8\u65ad\u51fa\u7406\u60f3\u7684\uff08AA\uff0cAT\uff0cTT\uff09\u7684\u5206\u5e03\uff0c\u7136\u540e\u548c\u5b9e\u9645\u89c2\u5bdf\u7684\u8fdb\u884c\u9002\u5408\u6027\u68c0\u9a8c\uff0c\u7136\u540e\u5f97\u5230P\u503c\uff0c\u6839\u636eP\u503c\u8fdb\u884c\u7b5b\u9009\u3002\u5373P\u503c\u8d8a\u5c0f\uff0c\u8bf4\u660e\u8be5\u4f4d\u70b9\u8d8a\u4e0d\u7b26\u5408\u54c8\u6e29\u5e73\u8861\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u76ee\u7684\u6709\u4e24\u4e2a\uff1a\u4e00\u662f\u8ba1\u7b97\u6240\u6709\u4f4d\u70b9\u7684\u54c8\u6e29\u68c0\u6d4b\u7ed3\u679c\uff1b\u4e8c\u662f\u5220\u9664SNP\u4e2d\u4e0d\u7b26\u5408\u54c8\u6e29\u5e73\u8861\u7684\u4f4d\u70b9<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"display: flex;flex-flow: row;text-align: center;justify-content: center;margin-top: 10px;margin-bottom: 20px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPDPrt26RzZWfLn13ExG96J6ol4mDfsGWCA12FKNAmAzca1KpiaaC6pyw\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 auto;align-self: stretch;min-width: 10%;height: auto;background-color: rgb(254, 227, 229);box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(84, 54, 54);padding-right: 10px;padding-left: 10px;text-align: justify;font-size: 17px;letter-spacing: 3px;\">\n<p style=\"white-space: normal;\"><strong>\u5b9e\u4f8b\u64cd\u4f5c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPpnvbMkq7WXX6UMv2c75MzmIH62rtwoDfxu3Tr5Nxr3B45Qwlxka2aQ\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>1. \u8ba1\u7b97\u6240\u6709\u4f4d\u70b9\u7684HWE\u7684P\u503c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">plink --bfile HapMap_3_r3_8 --hardy<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u4ecb\u7ecd\u4e00\u4e0bplink.hwe\u7684\u6570\u636e\u683c\u5f0f\uff1a<\/strong><br \/>CHR \u67d3\u8272\u4f53<br \/>SNP SNP\u7684ID<br \/>TEST \u7c7b\u578b<br \/>A1 minor \u4f4d\u70b9<br \/>A2 major \u4f4d\u70b9<br \/>GENO \u57fa\u56e0\u578b\u5206\u5e03\uff1aA1A1, A1A2, A2A2<br \/>O(HET) \u89c2\u6d4b\u6742\u5408\u5ea6\u9891\u7387<br \/>E(HET) \u671f\u671b\u6742\u5408\u5ea6\u9891\u7387<br \/>P \u54c8\u6e29\u5e73\u8861\u7684\u5361\u65b9\u68c0\u9a8cP-value\u503c<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.4368770764119601\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_OffQMfhh63mDibvMziceBeOJnU2sZg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPBdIVnPMtGI5TibOjhDbXwlOvyFjOffQMfhh63mDibvMziceBeOJnU2sZg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"602\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>2. \u63d0\u53d6\u54c8\u6e29p\u503c\u5c0f\u4e8e0.0001\u7684\u4f4d\u70b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u8fd9\u91cc\u6211\u4eec\u4f7f\u7528awk\uff1a<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">awk <span class=\"code-snippet__string\">'{if($9 < 0.0001) print $0}'<\/span> plink.hwe >plinkzoomhwe.hwe<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5171\u6709123\u4e2a\u4f4d\u70b9\uff0c\u5176\u4e2dUNAFF\u4e3a45\u4e2a\u4f4d\u70b9\u3002<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>3. \u8bbe\u5b9a\u8fc7\u6ee4\u6807\u51c61e-4<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">plink --bfile HapMap_3_r3_8 --hwe <span class=\"code-snippet__number\">1e-4<\/span> --make-bed --out HapMap_3_r3_9<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.11441647597254005\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_TsS8reqXB9Z38YAXxQTddC4ic5AHkA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPsPiaCuPszXdibISXrFWrphyLb0iaTsS8reqXB9Z38YAXxQTddC4ic5AHkA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"437\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u53ef\u4ee5\u770b\u5230\uff0c\u5171\u670945\u4e2aSNP\u6839\u636e\u54c8\u6e29\u7684P\u503c\u8fc7\u6ee4\u6389\u4e86\uff0c\u548c\u4e0a\u9762\u624b\u52a8\u8ba1\u7b97\u7684\u4e00\u6837\u3002<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>4. \u53ef\u89c6\u5316<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u54c8\u6e29\u7684P\u503c\u76f4\u65b9\u56fe\uff1a<\/strong><\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.0316742081447965\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_0MH5aLiaxFVwDtbWl9iak8vzXl5FfA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPxT4P6Nps1ibT3LhfQBdu2yCIbSF0MH5aLiaxFVwDtbWl9iak8vzXl5FfA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"884\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;border-color: rgb(176, 176, 176);padding: 7px;\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: rgba(249, 238, 237, 0.5);padding: 18px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;font-size: 14px;letter-spacing: 2px;line-height: 1.8;\">\n<p style=\"white-space: normal;\">\u5173\u4e8ePLINK\u8d28\u63a7\u4e2d\u7684\u54c8\u6e29\u5e73\u8861\u68c0\u9a8c\u5c0f\u56fe\u5c31\u4ecb\u7ecd\u5b8c\u6bd5\u4e86\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u7262\u8bb0\u5404\u4e2a\u6587\u4ef6\u7684\u7ed3\u6784\u4fe1\u606f\uff0c\u8fd9\u5728\u540e\u7eed\u7684\u6570\u636e\u5206\u6790\u4e2d\u975e\u5e38\u91cd\u8981\u3002\u53e6\u5916\u6b22\u8fce\u5c0f\u4f19\u4f34\u524d\u6765\u4f7f\u7528\uff1a\u4e91\u751f\u4fe1\u751f\u7269\u4fe1\u606f\u5b66\u5e73\u53f0\uff08 http:\/\/www.biocloudservice.com\/home.html\uff09\uff0c\u4e86\u89e3\u66f4\u591a\u751f\u4fe1\u77e5\u8bc6\u4e0e\u6280\u5de7\u5206\u6790\u3002<\/p>\n<p style=\"white-space: normal;\">\u8bf7\u671f\u5f85\u5c0f\u56fe\u7684\u4e0b\u4e00\u671fPLINK\u8d28\u63a7\u540e\u7eed\u5206\u4eab\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<\/section>\n<section style=\"text-align: justify;font-size: 14px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u6b22\u8fce\u4f7f\u7528\uff1a\u4e91\u751f\u4fe1\u5e73\u53f0 ( http:\/\/www.biocloudservice.com\/home.html)<\/p>\n<\/section>\n<section style=\"transform: scale(0.5);transform-origin: center center;margin-top: -65px;margin-bottom: -65px;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_Bk8Hn3YR4fTn9nt5mVpJIe1diadCeg.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPvsZ1NLJNWSg52AMibMuT2an6eXBk8Hn3YR4fTn9nt5mVpJIe1diadCeg\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"258\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:40.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:40.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;background-color: rgb(249, 174, 165);padding: 10px 0px;\" width=\"96.3700%\">\n<section style=\"line-height: 1;text-align: center;font-size: 17px;color: rgb(255, 255, 255);letter-spacing: 5px;\" powered-by=\"xiumi.us\">\n<p><strong>\u5f80\u671f\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:40.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:40.classicTable1:1.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<section style=\"font-size: 14px;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247484931&idx=1&sn=aed7fee5d33c476f473a869eab692e00&chksm=c1b17bfef6c6f2e87596c9bbf9669c62bd451f11e66f95e3eb0698fccd2ac7664ad819c25a30&scene=21#wechat_redirect\" textvalue=\"\u62df\u65f6\u5e8f\u5206\u6790\u4e0d\u4f1a\u505a\uff1fR\u5305Monocle3\u6765\u89e3\u51b3\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u62df\u65f6\u5e8f\u5206\u6790\u4e0d\u4f1a\u505a\uff1fR\u5305Monocle3\u6765\u89e3\u51b3<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:40.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:40.classicTable1:2.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<section style=\"font-size: 14px;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247484863&idx=1&sn=28a92146a8b2f04d0d5dc32bed20b527&chksm=c1b17842f6c6f154ac96a34752f22788d3ea4bf52a009dc72bd61f23b56b74a89eb72355e4d8&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u2014\u5982\u4f55\u4f7f\u7528GWAS summary\u6570\u636e\u5e93\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u2014\u5982\u4f55\u4f7f\u7528GWAS summary\u6570\u636e\u5e93<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:40.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:40.classicTable1:3.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<section style=\"font-size: 14px;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247484862&idx=1&sn=1b340dcdd7b13099951666fd6be2e017&chksm=c1b17843f6c6f155f7c2e8a64a4761a066e4e4deb7e9c39ebf938452f6d03ee21a6a4339f2c7&scene=21#wechat_redirect\" textvalue=\"\u8d85\u8be6\u7ec6\uff0c\u5c0f\u56fe\u5e26\u4f60\u7528beeswarm\u753b\u4f18\u96c5\u7684\u6563\u70b9\u871c\u8702\u56fe\u5206\u6790\u57fa\u56e0\u4e0e\u4e34\u5e8a\u76f8\u5173\u6027\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8d85\u8be6\u7ec6\uff0c\u5c0f\u56fe\u5e26\u4f60\u7528beeswarm\u753b\u4f18\u96c5\u7684\u6563\u70b9\u871c\u8702\u56fe\u5206\u6790\u57fa\u56e0\u4e0e\u4e34\u5e8a\u76f8\u5173\u6027<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\ud83d\udc47\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8fdb\u5165\u7f51\u5740<\/p>\n<\/section>\n<p style=\"display: none;margin-bottom: 24px;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<div class=\"msg_source_url\"><a href=\"http:\/\/www.biocloudservice.com\/home.html\" target=\"_blank\" rel=\"noopener\">\u9605\u8bfb\u539f\u6587<\/a><\/div>\n<p><\/content><\/p>\n<div class=\"msg_source_url\"><a href=\"http:\/\/www.biocloudservice.com\/home.html\" target=\"_blank\" rel=\"noopener\">\u9605\u8bfb\u539f\u6587<\/a><\/div>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010PLINK\u8d28\u91cf\u63a7\u5236\u3011\u54c8\u6e29\u5e73\u8861\u662f\u4ec0\u4e48\uff1f\u4e3a\u4ec0\u4e48\u8fdb\u884c\u54c8\u6e29\u5e73\u8861\u8fc7\u6ee4\uff1f \u5c0f\u56fe \u751f\u4fe1\u679c […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/50797"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=50797"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/50797\/revisions"}],"predecessor-version":[{"id":50807,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/50797\/revisions\/50807"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=50797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=50797"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=50797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

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middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.3212996389891697\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_BXxPMpJSLIwQHMCvQDSjaq97Bjmc0w.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLP4kr894SiaExxeJwAU4Elp0HzGBXxPMpJSLIwQHMCvQDSjaq97Bjmc0w\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"277\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: justify;line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u53ef\u4ee5\u5e94\u7528\u5361\u65b9\u68c0\u9a8c\u6765\u9a8c\u8bc1Hardy-Weinberg\u5e73\u8861\uff0c\u628a\u8ba1\u7b97\u5f97\u5230\u7684\u57fa\u56e0\u9891\u7387\u4ee3\u5165\uff0c\u8ba1\u7b97\u57fa\u56e0\u578b\u5e73\u8861\u9891\u7387\uff0c\u518d\u4e58\u4ee5\u603b\u4eba\u6570\uff0c\u6c42\u5f97\u9884\u671f\u503c\uff08e\uff09\u3002\u628a\u89c2\u5bdf\u6570\uff08O\uff09\u4e0e\u9884\u671f\u503c\uff08E\uff09\u4f5c\u6bd4\u8f83\uff0c\u8fdb\u884c\u03c72\u68c0\u9a8c\u3002\u75c5\u4f8b\u7ec4\u548c\u5bf9\u7167\u7ec4\u7684\u57fa\u56e0\u578b\u5206\u5e03\u7684\u89c2\u5bdf\u503c\u548c\u9884\u671f\u503c\u5dee\u5f02\u65e0\u663e\u8457\u6027\uff08P>0.05\uff09\uff0c\u7b26\u5408\u9057\u4f20\u5e73\u8861\u5b9a\u5f8b:\u6bd4\u5982\u4e0b\u56fe\u4e3a\u4e00\u4e2a\u5177\u4f53\u7684Hardy-Weinberg\u9057\u4f20\u5e73\u8861\u68c0\u9a8c\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"display: flex;flex-flow: row;text-align: center;justify-content: center;margin-top: 10px;margin-bottom: 20px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPDPrt26RzZWfLn13ExG96J6ol4mDfsGWCA12FKNAmAzca1KpiaaC6pyw\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 auto;align-self: stretch;min-width: 10%;height: auto;background-color: rgb(254, 227, 229);box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(84, 54, 54);padding-right: 10px;padding-left: 10px;text-align: justify;font-size: 17px;letter-spacing: 3px;\">\n<p style=\"white-space: normal;\"><strong>\u5c0f\u56fe\u4e3e\u4f8b\u8bf4\u660e\u4e00\u4e0b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPpnvbMkq7WXX6UMv2c75MzmIH62rtwoDfxu3Tr5Nxr3B45Qwlxka2aQ\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.7121879588839941\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_IMhjf0ZuDibrAYI6mjE0NFsxX0Vhlw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPpu4dUicKXiaBOKn3QqzfVbcYI1xIMhjf0ZuDibrAYI6mjE0NFsxX0Vhlw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"681\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.4077669902912621\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_iaOLzulkibmy37GAMRSpTyLzZMOXPw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPGKSC8AYPdccw4ibjGqKCC75hiaMTiaOLzulkibmy37GAMRSpTyLzZMOXPw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"721\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.4361111111111111\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_3ul6kiaTenhDkE1VV7IYTNM1IuZ4pA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPQ2OsZ1HHEv6KjaiaXAmHS4iaFTp3ul6kiaTenhDkE1VV7IYTNM1IuZ4pA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">HO:\u89c2\u6d4b\u503c\u7b26\u5408\u57fa\u56e0\u5e73\u8861\u5b9a\u5f8b\u5206\u5e03\uff1b<\/p>\n<p style=\"white-space: normal;\">HA\uff1a\u89c2\u6d4b\u503c\u4e0d\u7b26\u5408\u57fa\u56e0\u5e73\u8861\u5b9a\u5f8b\u5206\u5e03\uff1b<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\"> MM=<span class=\"code-snippet__number\">233<\/span>;MN=<span class=\"code-snippet__number\">385<\/span>;NN=<span class=\"code-snippet__number\">129<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> pm=(MM+<span class=\"code-snippet__number\">1<\/span>\/<span class=\"code-snippet__number\">2<\/span>*MN)\/(MM+MN+NN);qn=(NN+<span class=\"code-snippet__number\">1<\/span>\/<span class=\"code-snippet__number\">2<\/span>*MN)\/(MM+MN+NN)<\/span><\/code><code><span class=\"code-snippet_outer\"> p=pm*pm;H=<span class=\"code-snippet__number\">2<\/span>*pm*qn;Q=qn*qn<\/span><\/code><code><span class=\"code-snippet_outer\"> p=c(P,H,Q)<\/span><\/code><code><span class=\"code-snippet_outer\"> data=c(MM,MN,NN)<\/span><\/code><code><span class=\"code-snippet_outer\"> chisq.test(data,p=p)<\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u7ed3\u679c\u663e\u793a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.17857142857142858\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_R5HlDjlapHEzXGbSTCHtEVYxB9NSNw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPRUgFpbQlV2Sp8XBcJMt5f6nuR5HlDjlapHEzXGbSTCHtEVYxB9NSNw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"840\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: -14px;transform: translate3d(13px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;background-color: rgb(255, 255, 255);padding-right: 15px;padding-left: 13px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;background-color: rgb(206, 233, 255);min-width: 5%;height: auto;padding: 5px 22px;\">\n<section style=\"text-align: justify;font-size: 18px;color: rgb(62, 62, 62);letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u54c8\u6e29\u5e73\u8861\u8fc7\u6ee4\u548cMAF\u8fc7\u6ee4\u7684\u533a\u522b\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;min-width: 5%;flex: 0 0 auto;height: auto;\">\n<section style=\"transform: perspective(0px);transform-style: flat;\" powered-by=\"xiumi.us\">\n<section style=\"transform: translate3d(5px, 0px, 0px) rotateX(180deg);\">\n<section style=\"display: inline-block;width: 6px;height: 6px;vertical-align: top;overflow: hidden;border-radius: 460px;background-color: rgb(244, 171, 189);\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 3px;border-color: rgb(244, 171, 189);padding: 18px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;line-height: 1.8;letter-spacing: 1.5px;\">\n<p style=\"white-space: normal;\">\u8fd9\u4e24\u4e2a\u6982\u5ff5\u4e00\u4e2a\u662f\u5bf9\u57fa\u56e0\u9891\u7387\u8fdb\u884c\u7684\u7b5b\u9009\uff0c\u4e00\u4e2a\u662f\u5bf9\u57fa\u56e0\u578b\u9891\u7387\u8fdb\u884c\u7684\u7b5b\u9009\u3002\u5bf9\u4e8e\u4e00\u4e2a\u4f4d\u70b9\u201cAA AT TT\u201d\uff0c\u5176\u4e2dA\u7684\u9891\u7387\u4e3a\u57fa\u56e0\u9891\u7387\uff0cAA\u4e3a\u57fa\u56e0\u578b\u9891\u7387\u3002MAF\u76f4\u63a5\u662f\u5bf9\u57fa\u56e0\u9891\u7387\u8fdb\u884c\u7b5b\u9009\uff0c\u800c\u54c8\u6e29\u5e73\u8861\u68c0\u9a8c\uff0c\u5219\u662f\u6839\u636e\u57fa\u56e0\u578b\u63a8\u65ad\u51fa\u7406\u60f3\u7684\uff08AA\uff0cAT\uff0cTT\uff09\u7684\u5206\u5e03\uff0c\u7136\u540e\u548c\u5b9e\u9645\u89c2\u5bdf\u7684\u8fdb\u884c\u9002\u5408\u6027\u68c0\u9a8c\uff0c\u7136\u540e\u5f97\u5230P\u503c\uff0c\u6839\u636eP\u503c\u8fdb\u884c\u7b5b\u9009\u3002\u5373P\u503c\u8d8a\u5c0f\uff0c\u8bf4\u660e\u8be5\u4f4d\u70b9\u8d8a\u4e0d\u7b26\u5408\u54c8\u6e29\u5e73\u8861\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u76ee\u7684\u6709\u4e24\u4e2a\uff1a\u4e00\u662f\u8ba1\u7b97\u6240\u6709\u4f4d\u70b9\u7684\u54c8\u6e29\u68c0\u6d4b\u7ed3\u679c\uff1b\u4e8c\u662f\u5220\u9664SNP\u4e2d\u4e0d\u7b26\u5408\u54c8\u6e29\u5e73\u8861\u7684\u4f4d\u70b9<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"display: flex;flex-flow: row;text-align: center;justify-content: center;margin-top: 10px;margin-bottom: 20px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPDPrt26RzZWfLn13ExG96J6ol4mDfsGWCA12FKNAmAzca1KpiaaC6pyw\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 auto;align-self: stretch;min-width: 10%;height: auto;background-color: rgb(254, 227, 229);box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(84, 54, 54);padding-right: 10px;padding-left: 10px;text-align: justify;font-size: 17px;letter-spacing: 3px;\">\n<p style=\"white-space: normal;\"><strong>\u5b9e\u4f8b\u64cd\u4f5c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPpnvbMkq7WXX6UMv2c75MzmIH62rtwoDfxu3Tr5Nxr3B45Qwlxka2aQ\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>1. \u8ba1\u7b97\u6240\u6709\u4f4d\u70b9\u7684HWE\u7684P\u503c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">plink --bfile HapMap_3_r3_8 --hardy<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u4ecb\u7ecd\u4e00\u4e0bplink.hwe\u7684\u6570\u636e\u683c\u5f0f\uff1a<\/strong><br \/>CHR \u67d3\u8272\u4f53<br \/>SNP SNP\u7684ID<br \/>TEST \u7c7b\u578b<br \/>A1 minor \u4f4d\u70b9<br \/>A2 major \u4f4d\u70b9<br \/>GENO \u57fa\u56e0\u578b\u5206\u5e03\uff1aA1A1, A1A2, A2A2<br \/>O(HET) \u89c2\u6d4b\u6742\u5408\u5ea6\u9891\u7387<br \/>E(HET) \u671f\u671b\u6742\u5408\u5ea6\u9891\u7387<br \/>P \u54c8\u6e29\u5e73\u8861\u7684\u5361\u65b9\u68c0\u9a8cP-value\u503c<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.4368770764119601\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_OffQMfhh63mDibvMziceBeOJnU2sZg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPBdIVnPMtGI5TibOjhDbXwlOvyFjOffQMfhh63mDibvMziceBeOJnU2sZg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"602\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>2. \u63d0\u53d6\u54c8\u6e29p\u503c\u5c0f\u4e8e0.0001\u7684\u4f4d\u70b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u8fd9\u91cc\u6211\u4eec\u4f7f\u7528awk\uff1a<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">awk <span class=\"code-snippet__string\">'{if($9 < 0.0001) print $0}'<\/span> plink.hwe >plinkzoomhwe.hwe<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5171\u6709123\u4e2a\u4f4d\u70b9\uff0c\u5176\u4e2dUNAFF\u4e3a45\u4e2a\u4f4d\u70b9\u3002<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>3. \u8bbe\u5b9a\u8fc7\u6ee4\u6807\u51c61e-4<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">plink --bfile HapMap_3_r3_8 --hwe <span class=\"code-snippet__number\">1e-4<\/span> --make-bed --out HapMap_3_r3_9<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.11441647597254005\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_TsS8reqXB9Z38YAXxQTddC4ic5AHkA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPsPiaCuPszXdibISXrFWrphyLb0iaTsS8reqXB9Z38YAXxQTddC4ic5AHkA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"437\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u53ef\u4ee5\u770b\u5230\uff0c\u5171\u670945\u4e2aSNP\u6839\u636e\u54c8\u6e29\u7684P\u503c\u8fc7\u6ee4\u6389\u4e86\uff0c\u548c\u4e0a\u9762\u624b\u52a8\u8ba1\u7b97\u7684\u4e00\u6837\u3002<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>4. \u53ef\u89c6\u5316<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u54c8\u6e29\u7684P\u503c\u76f4\u65b9\u56fe\uff1a<\/strong><\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.0316742081447965\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_0MH5aLiaxFVwDtbWl9iak8vzXl5FfA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPxT4P6Nps1ibT3LhfQBdu2yCIbSF0MH5aLiaxFVwDtbWl9iak8vzXl5FfA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"884\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;border-color: rgb(176, 176, 176);padding: 7px;\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: rgba(249, 238, 237, 0.5);padding: 18px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;font-size: 14px;letter-spacing: 2px;line-height: 1.8;\">\n<p style=\"white-space: normal;\">\u5173\u4e8ePLINK\u8d28\u63a7\u4e2d\u7684\u54c8\u6e29\u5e73\u8861\u68c0\u9a8c\u5c0f\u56fe\u5c31\u4ecb\u7ecd\u5b8c\u6bd5\u4e86\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u7262\u8bb0\u5404\u4e2a\u6587\u4ef6\u7684\u7ed3\u6784\u4fe1\u606f\uff0c\u8fd9\u5728\u540e\u7eed\u7684\u6570\u636e\u5206\u6790\u4e2d\u975e\u5e38\u91cd\u8981\u3002\u53e6\u5916\u6b22\u8fce\u5c0f\u4f19\u4f34\u524d\u6765\u4f7f\u7528\uff1a\u4e91\u751f\u4fe1\u751f\u7269\u4fe1\u606f\u5b66\u5e73\u53f0\uff08 http:\/\/www.biocloudservice.com\/home.html\uff09\uff0c\u4e86\u89e3\u66f4\u591a\u751f\u4fe1\u77e5\u8bc6\u4e0e\u6280\u5de7\u5206\u6790\u3002<\/p>\n<p style=\"white-space: normal;\">\u8bf7\u671f\u5f85\u5c0f\u56fe\u7684\u4e0b\u4e00\u671fPLINK\u8d28\u63a7\u540e\u7eed\u5206\u4eab\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<\/section>\n<section style=\"text-align: justify;font-size: 14px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u6b22\u8fce\u4f7f\u7528\uff1a\u4e91\u751f\u4fe1\u5e73\u53f0 ( http:\/\/www.biocloudservice.com\/home.html)<\/p>\n<\/section>\n<section style=\"transform: scale(0.5);transform-origin: center center;margin-top: -65px;margin-bottom: -65px;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_Bk8Hn3YR4fTn9nt5mVpJIe1diadCeg.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/2wJ7bWfS0QsK3bt5BgR7soicwrXZEfsLPvsZ1NLJNWSg52AMibMuT2an6eXBk8Hn3YR4fTn9nt5mVpJIe1diadCeg\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"258\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:40.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:40.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;background-color: rgb(249, 174, 165);padding: 10px 0px;\" width=\"96.3700%\">\n<section style=\"line-height: 1;text-align: center;font-size: 17px;color: rgb(255, 255, 255);letter-spacing: 5px;\" powered-by=\"xiumi.us\">\n<p><strong>\u5f80\u671f\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:40.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:40.classicTable1:1.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<section style=\"font-size: 14px;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247484931&idx=1&sn=aed7fee5d33c476f473a869eab692e00&chksm=c1b17bfef6c6f2e87596c9bbf9669c62bd451f11e66f95e3eb0698fccd2ac7664ad819c25a30&scene=21#wechat_redirect\" textvalue=\"\u62df\u65f6\u5e8f\u5206\u6790\u4e0d\u4f1a\u505a\uff1fR\u5305Monocle3\u6765\u89e3\u51b3\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u62df\u65f6\u5e8f\u5206\u6790\u4e0d\u4f1a\u505a\uff1fR\u5305Monocle3\u6765\u89e3\u51b3<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:40.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:40.classicTable1:2.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<section style=\"font-size: 14px;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247484863&idx=1&sn=28a92146a8b2f04d0d5dc32bed20b527&chksm=c1b17842f6c6f154ac96a34752f22788d3ea4bf52a009dc72bd61f23b56b74a89eb72355e4d8&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u2014\u5982\u4f55\u4f7f\u7528GWAS summary\u6570\u636e\u5e93\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u2014\u5982\u4f55\u4f7f\u7528GWAS summary\u6570\u636e\u5e93<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:40.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:40.classicTable1:3.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<section style=\"font-size: 14px;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247484862&idx=1&sn=1b340dcdd7b13099951666fd6be2e017&chksm=c1b17843f6c6f155f7c2e8a64a4761a066e4e4deb7e9c39ebf938452f6d03ee21a6a4339f2c7&scene=21#wechat_redirect\" textvalue=\"\u8d85\u8be6\u7ec6\uff0c\u5c0f\u56fe\u5e26\u4f60\u7528beeswarm\u753b\u4f18\u96c5\u7684\u6563\u70b9\u871c\u8702\u56fe\u5206\u6790\u57fa\u56e0\u4e0e\u4e34\u5e8a\u76f8\u5173\u6027\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8d85\u8be6\u7ec6\uff0c\u5c0f\u56fe\u5e26\u4f60\u7528beeswarm\u753b\u4f18\u96c5\u7684\u6563\u70b9\u871c\u8702\u56fe\u5206\u6790\u57fa\u56e0\u4e0e\u4e34\u5e8a\u76f8\u5173\u6027<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\ud83d\udc47\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8fdb\u5165\u7f51\u5740<\/p>\n<\/section>\n<p style=\"display: none;margin-bottom: 24px;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<div class=\"msg_source_url\"><a href=\"http:\/\/www.biocloudservice.com\/home.html\" target=\"_blank\" rel=\"noopener\">\u9605\u8bfb\u539f\u6587<\/a><\/div>\n<p><\/content><\/p>\n<div class=\"msg_source_url\"><a href=\"http:\/\/www.biocloudservice.com\/home.html\" target=\"_blank\" rel=\"noopener\">\u9605\u8bfb\u539f\u6587<\/a><\/div>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010PLINK\u8d28\u91cf\u63a7\u5236\u3011\u54c8\u6e29\u5e73\u8861\u662f\u4ec0\u4e48\uff1f\u4e3a\u4ec0\u4e48\u8fdb\u884c\u54c8\u6e29\u5e73\u8861\u8fc7\u6ee4\uff1f \u5c0f\u56fe \u751f\u4fe1\u679c 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