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onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxqaqPbQprPd4vw8Ytp0cprbzXiakMDdFriaB6B59ibhlBCrNyQFf6PG40Qrdu5e9B1iaIMItPiajABYWA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 182px;height: 182px;\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: left;line-height: 200%;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009543\" data-ratio=\"0.20710659898477157\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_YHQiaUftGCGz2HYsM7QichytaW3wPQ-1.png?resize=553%2C114\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx40DbJKKXHudTS1E95gfxwexibvToTia9WAViaibnzicGtlhLpNj8aYHQiaUftGCGz2HYsM7QichytaW3wPQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"985\" height=\"114 .6500244140625\" width=\"553 .6300048828125\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:12.0pt;line-height:200%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"margin-left: 21pt;text-indent: -21pt;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;font-family:Wingdings;mso-ascii-font-family:Wingdings;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#ED7D31;\">l<span style=\"font:7.0pt Times New Roman;\"><\/span><\/span><span style=\"font-size:12.0pt;line-height:150%;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u9898\u76ee\uff1a\u76d8\u72b6\u86cb\u767d\u7ed3\u6784\u57df\u53d7\u4f53\u9a71\u52a8\u7684\u57fa\u56e0\u7b7e\u540d\u4f5c\u4e3a\u60a3\u8005\u5bf9\u6297PD-L1\u514d\u75ab\u68c0\u67e5\u70b9\u6cbb\u7597\u53cd\u5e94\u7684\u6807\u8bb0\u7269<\/span><\/p>\n<p style=\"margin-left: 21pt;text-indent: -21pt;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;font-family:Wingdings;mso-ascii-font-family:Wingdings;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#ED7D31;\">l<span style=\"font:7.0pt Times New Roman;\"><\/span><\/span><span style=\"font-size:12.0pt;line-height:150%;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u6742\u5fd7\uff1a<\/span><span style=\"font-size:12.0pt;line-height:150%;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:Segoe UI;font-variant:normal;text-transform:none;color:#0071BC;background:#FFFFFF;\">Journal of Clinical Investigation<\/span><span style=\"font-size:12.0pt;line-height:150%;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span>    <o:page><\/o:page><\/p>\n<p style=\"margin-left: 21pt;text-indent: -21pt;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;font-family:Wingdings;mso-ascii-font-family:Wingdings;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#ED7D31;\">l<span style=\"font:7.0pt Times New Roman;\"><\/span><\/span><span style=\"font-size:12.0pt;line-height:150%;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=15.9<\/span><\/p>\n<p style=\"margin-left: 21pt;text-indent: -21pt;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;font-family:Wingdings;mso-ascii-font-family:Wingdings;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#ED7D31;\">l<span style=\"font:7.0pt Times New Roman;\"><\/span><\/span><span style=\"font-size:12.0pt;line-height:150%;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u53d1\u8868\u65f6\u95f4\uff1a2022\u5e7410\u6708<\/span><\/p>\n<p style=\"margin-left: 21pt;text-indent: -21pt;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;line-height:150%;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u7814\u7a76\u80cc\u666f<\/span><\/p>\n<p style=\"line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u6297PD-1\u548cPD-L1\u514d\u75ab\u68c0\u67e5\u70b9\u6cbb\u7597\uff08ICT\uff09\u53ea\u5bf9\u90e8\u5206\u764c\u75c7\u60a3\u8005\u6709\u6301\u4e45\u7684\u53cd\u5e94\uff0c\u6240\u4ee5\u9700\u8981\u751f\u7269\u6807\u5fd7\u7269\u6765\u9884\u6d4b\u975e\u53cd\u5e94\u8005\u3002\u5f53\u524d\u7684\u9884\u6d4b\u751f\u7269\u6807\u5fd7\u7269\u5982PD-L1\u8fc7\u8868\u8fbe\u3001\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u7b49\u90fd\u6709\u5c40\u9650\u6027\uff0c\u56e0\u6b64\u9700\u8981\u6539\u8fdb\u6216\u627e\u51fa\u65b0\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u4f5c\u8005\u53d1\u73b0DDR2\u8868\u8fbe\u662f\u5c0f\u9f20\u6a21\u578b\u4e2dICT\u53cd\u5e94\u7684\u51b3\u5b9a\u56e0\u7d20\uff0c\u5e76\u4f7f\u7528\u9057\u4f20\u548c\u836f\u7406\u65b9\u6cd5\u8868\u660e\u6291\u5236DDR2\u53ef\u4ee5\u589e\u5f3a\u5c0f\u9f20\u7684ICT\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u4ed6\u4eec\u63a8\u65ad\u7531DDR2\u6216\u5176\u5bb6\u65cf\u6210\u5458DDR1\u8c03\u8282\u7684\u57fa\u56e0\u8868\u8fbe\u7b7e\u540d\u53ef\u4ee5\u533a\u5206\u60a3\u8005\u5bf9ICT\u7684\u53cd\u5e94\u3002<\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;line-height:150%;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u7814\u7a76\u601d\u8def<\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;line-height:150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009541\" data-ratio=\"0.6462962962962963\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_YnJd9DkC3o3kVgt6C1fe9bMlmn2icQ-1.jpg?resize=525%2C340\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx40DbJKKXHudTS1E95gfxwe6MeSHS0spy3ibVeKEn0Dxfj6FPYnJd9DkC3o3kVgt6C1fe9bMlmn2icQ\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" height=\"340 .1300048828125\" width=\"525 .9400024414062\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;line-height:150%;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u4e3b\u8981\u7ed3\u679c<\/span><\/p>\n<p style=\"mso-list:l0 level1 lfo1;margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;margin-left:0.0pt;text-indent:0.0pt;line-height:150%;\"><span style=\"color: rgb(0, 82, 255);\"><span style=\"color: rgb(0, 82, 255);font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">1.<\/span><span style=\"color: rgb(0, 82, 255);font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u8180\u80f1\u764c\u4e2dDDR1\/2\u57fa\u56e0\u7684\u8868\u8fbe<\/span><\/span>    <o:page><\/o:page><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-indent:24.0pt;mso-char-indent-count:2.0;mso-char-indent-size:12.0;line-height:150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4f5c\u8005\u5c06<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">TCGA\u6570\u636e\u5e93<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e2d\u7684\u8180\u80f1\u764c\u60a3\u8005\u6839\u636eDDR1\u548cDDR2\u7684\u8868\u8fbe\u6c34\u5e73\u5206\u4e3a4\u7ec4\u3002\u518d\u6536\u96c6\u6bcf\u7ec4\u60a3\u8005\u7684<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u4e34\u5e8a\u75c5\u7406\u7279\u5f81<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\uff0c\u5305\u62ec\u6027\u522b\u3001\u75c5\u7406\u5206\u671f\u3001T\u5206\u671f\u3001\u590d\u53d1\u72b6\u51b5\u3001\u603b\u751f\u5b58\u72b6\u6001\u548c\u80bf\u7624\u5206\u7ea7\u3002\u7814\u7a76\u53d1\u73b0<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">DDR<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u8868\u8fbe\u7fa4\u4f53\u4e0e\u7279\u5b9a\u7684\u4e34\u5e8a\u7279\u5f81\u76f8\u5173\uff0c\u4f8b\u5982DDR2<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u8868\u8fbe\u66f4\u5e38\u89c1\u4e8e\u57fa\u8d28\u4e30\u5bcc\u7684\u4e9a\u578b\u3002<\/span><span style=\"text-indent: 24pt;letter-spacing: 0.034em;font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;\">       <\/span><span style=\"text-indent: 24pt;font-family: "Times New Roman";font-size: 12pt;letter-spacing: 0.034em;\">        <\/span><span style=\"text-indent: 24pt;font-family: "Times New Roman";font-size: 12pt;letter-spacing: 0.034em;\"><\/span><span style=\"text-indent: 24pt;font-family: "Times New Roman";font-size: 12pt;letter-spacing: 0.034em;\">         <\/span><span style=\"text-indent: 24pt;font-family: "Times New Roman";font-size: 12pt;letter-spacing: 0.034em;\"><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">Table 1. Clinicopathological characteristics of TCGA BCa cohort by DDR expression levels<\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;line-height:150%;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009539\" data-ratio=\"1.088176352705411\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_YsNrS7ibCfIo5KIOcxOGic8t2APNaA-1.png?resize=431%2C469\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx40DbJKKXHudTS1E95gfxweJwCDwdg9EOaRKn6nyiaqA8LbcxDYsNrS7ibCfIo5KIOcxOGic8t2APNaA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"499\" height=\"469 .1600036621094\" width=\"431 .1399841308594\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-indent:24.0pt;mso-char-indent-count:2.0;mso-char-indent-size:12.0;line-height:150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4f5c\u8005\u5229\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">TCGA<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u8180\u80f1\u764c\u6570\u636e\u96c6(n=259)\uff0c\u901a\u8fc7<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u975e\u76d1\u7763\u805a\u7c7b<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u5206\u6790DDR1\u548cDDR2\u7684\u8868\u8fbe\u6a21\u5f0f\u3002\u8ba1\u7b97DDR1\u548cDDR2\u8868\u8fbe\u7684<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">Spearman\u76f8\u5173<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u7cfb\u6570\u3002\u5c06\u6837\u672c\u6309\u5206\u5b50\u4e9a\u578b\u8fdb\u884c\u5206\u7ec4\uff0c\u6bd4\u8f83\u5404\u7ec4DDR1\/2\u7684\u8868\u8fbe\u5206\u5e03\u3002\u5229\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">Kaplan-Meier<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u5206\u6790\u6bd4\u8f83DDR1\/2\u9ad8\u4f4e\u8868\u8fbe\u7ec4\u7684\u751f\u5b58\u66f2\u7ebf\u3002\u7814\u7a76\u53d1\u73b0<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">DDR1\u548cDDR2\u8868\u8fbe\u5448\u76f8\u53cd\u8d8b\u52bf\uff08Spearman\u7cfb\u6570\u4e3a-0.27\uff09\u3002DDR1<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u8868\u8fbe\u66f4\u591a\u89c1\u4e8eLumP\u4e9a\u578b\uff0cDDR2<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u8868\u8fbe\u66f4\u591a\u89c1\u4e8e\u57fa\u8d28\u4e30\u5bcc\u4e9a\u578b\u3002DDR2<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u8868\u8fbe\u7ec4\u603b\u751f\u5b58\u66f4\u77ed(HR=1.55,P=0.02)\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"margin-top: 7.8pt;margin-bottom: 7.8pt;line-height: 150%;text-align: center;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009540\" data-ratio=\"1.4297820823244551\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_5pzYeDzNsJMTJbYpptYyB5ibmLdDbA-1.png?resize=550%2C787\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx40DbJKKXHudTS1E95gfxweiahOzO9xFIXAJvTTEMXvS5UGOV5pzYeDzNsJMTJbYpptYyB5ibmLdDbA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"826\" height=\"787 .3499755859375\" width=\"550 .6799926757812\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span>    <o:page><\/o:page><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">Figure 1. Expression of DDR genes in human bladder tumors as a function of molecular subtype and clinical outcome<\/span><\/p>\n<p style=\"mso-list:l0 level1 lfo1;margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;margin-left:0.0pt;text-indent:0.0pt;line-height:150%;\"><span style=\"color: rgb(0, 82, 255);\"><span style=\"color: rgb(0, 82, 255);font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">2.DDR1<sup>high<\/sup><\/span><span style=\"color: rgb(0, 82, 255);font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u548cDDR2<\/span><span style=\"color: rgb(0, 82, 255);font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\"><sup>high<\/sup><\/span><span style=\"color: rgb(0, 82, 255);font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u7684\u8180\u80f1\u80bf\u7624\u5fae\u73af\u5883<\/span><\/span>    <o:page><\/o:page><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-indent:24.0pt;mso-char-indent-count:2.0;mso-char-indent-size:12.0;line-height:150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4f5c\u8005\u5229\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">GSEA<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u6bd4\u8f83DDR1<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u8868\u8fbe\u548cDDR2<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u8868\u8fbe\u80bf\u7624\u5bcc\u96c6\u7684<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u57fa\u56e0\u901a\u8def<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u3002\u5e76\u8ba1\u7b97DDR1\/2\u8868\u8fbe\u4e0e23\u79cd\u514d\u75ab\u7ec6\u80de\u79ef\u5206\u7684<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u76f8\u5173\u6027<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u3002\u518d\u5229\u7528DDR1\/2\u8868\u8fbe\u6c34\u5e73\u548cT\u7ec6\u80de\u708e\u6027\u57fa\u56e0\u8868\u8fbe\u8c31\uff08GEP\uff09\u8fdb\u884c<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u751f\u5b58\u5206\u6790<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u3002\u7814\u7a76\u53d1\u73b0<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">DDR1<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u8868\u8fbe\u7ec4\u5bcc\u96c6\u4e0a\u76ae\u53d1\u80b2\u7b49\u901a\u8def\uff0cDDR2<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u8868\u8fbe\u7ec4\u5bcc\u96c6\u514d\u75ab\u76f8\u5173\u901a\u8def\u3002DDR1<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u8868\u8fbe\u4e0e\u514d\u75ab\u201c\u51b7\u201d\u80bf\u7624\u76f8\u5173\uff0cDDR2<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u8868\u8fbe\u4e0e\u514d\u75ab\u201c\u70ed\u201d\u80bf\u7624\u76f8\u5173\u3002DDR2<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>low<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u8868\u8fbe\u4e14GEP<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u8868\u8fbe\u7ec4\u9884\u540e\u6700\u597d\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"margin-top: 7.8pt;margin-bottom: 7.8pt;line-height: 150%;text-align: center;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009542\" data-ratio=\"1.2649006622516556\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_diaOl2wwxQsAciaoxiaCsqJg3p308Q-1.png?resize=553%2C699\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx40DbJKKXHudTS1E95gfxweuvRMEeXibExciadlw9GXDDGzhYMiaVdiaOl2wwxQsAciaoxiaCsqJg3p308Q\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"906\" height=\"699 .8300170898438\" width=\"553 .27001953125\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;text-indent:21.0pt;mso-char-indent-count:2.0;mso-char-indent-size:10.5;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">Figure 2. Impact of DDR expression on gene set enrichment analysis, molecularly defined cellular composition, and T-cell-inflamed GEP in human bladder tumors<\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-indent:24.0pt;mso-char-indent-count:2.0;mso-char-indent-size:12.0;line-height:150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4f5c\u8005\u5c06\u80bf\u7624\u6837\u672c\u5206\u4e3aDDR\u9ad8\u4f4e\u8868\u8fbe\u548cGEP\u9ad8\u4f4e\u8868\u8fbe\u4e24\u7ec4\u3002\u751f\u5b58\u5206\u6790\u91c7\u7528\u591a\u91cd<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">Log-rank<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u68c0\u9a8c\uff0c\u4ee5DDR<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>low<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u548cGEP<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>low<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u7ec4\u4f5c\u4e3a\u57fa\u7ebf\u3002\u7814\u7a76\u53d1\u73b0<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u5728TCGA\u6570\u636e\u96c6\u4e2dDDR1<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>low<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u548cGEP<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>low<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u7ec4\u9884\u540e\u6700\u5dee\u3002\u5728IMvigor\u6570\u636e\u96c6\u4e2dDDR2<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>low<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u548cGEP<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u7ec4\u9884\u540e\u6700\u597d\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;text-indent:21.0pt;mso-char-indent-count:2.0;mso-char-indent-size:10.5;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">Table 2. Multiple log-rank tests were performed with DDR<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>low<\/sup><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"> and GEP<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>high<\/sup><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"> group as baseline in TCGA BCa and IMvigor<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>a<\/sup><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009544\" data-ratio=\"1.0533596837944663\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_9Lsy8DupG2W6GZHA8WTr0P6Gt7Qshg-1.png?resize=480%2C506\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx40DbJKKXHudTS1E95gfxwekx9iaIjd0p0DllkVvjFy3Gq099Lsy8DupG2W6GZHA8WTr0P6Gt7Qshg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"506\" height=\"506 .0\" width=\"480 .02996826171875\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"mso-list:l0 level1 lfo1;margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;margin-left:0.0pt;text-indent:0.0pt;line-height:150%;\"><span style=\"color: rgb(0, 82, 255);font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">3.DDR\u8868\u8fbe\u4e0eICT\u54cd\u5e94\u7684\u5173\u8054<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-indent:24.0pt;mso-char-indent-count:2.0;mso-char-indent-size:12.0;line-height:150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4f5c\u8005\u5229\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">IMvigor210\u6570\u636e\u96c6<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u5206\u6790DDR1\/2\u8868\u8fbe\u4e0e23\u79cd\u514d\u75ab\u7ec6\u80de\u7c7b\u578b\u7684\u76f8\u5173\u6027\u3002\u5229\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u70ed\u56fe<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u548c<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u6563\u70b9\u56fe<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u663e\u793aDDR1\u548cDDR2\u7684\u8868\u8fbe\u6a21\u5f0f\u3002\u5229\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u7bb1\u7ebf\u56fe<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u6bd4\u8f83\u4e0d\u540c\u6cbb\u7597\u53cd\u5e94\u7ec4\u7684DDR1\/2\u8868\u8fbe\u6c34\u5e73\u3002\u5229\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">Kaplan-Meier\u66f2\u7ebf<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u5206\u6790\u4e0d\u540cDDR\u8868\u8fbe\u5bf9\u751f\u5b58\u7684\u5f71\u54cd\u3002\u7814\u7a76\u53d1\u73b0<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">DDR1\u4e0e\u201c\u51b7\u201d\u80bf\u7624\u76f8\u5173\uff0cDDR2\u4e0e\u201c\u70ed\u201d\u80bf\u7624\u76f8\u5173\u3002DDR1\/2\u7684\u8868\u8fbe\u672c\u8eab\u5e76\u4e0d\u80fd\u9884\u6d4b\u6cbb\u7597\u53cd\u5e94\u6216\u751f\u5b58\u3002\u8054\u5408DDR\u548cGEP\u4e5f\u672a\u663e\u793a\u751f\u5b58\u5dee\u5f02\u3002<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4ee5\u4e0a\u7ed3\u679c\u8868\u660eDDR1\/2\u8868\u8fbe\u672c\u8eab\u5e76\u4e0d\u80fd\u9884\u6d4b\u6297PD-L1\u6cbb\u7597\u53cd\u5e94\uff0c\u9700\u8981\u5f00\u53d1\u57fa\u4e8eDDR\u7684\u57fa\u56e0\u7b7e\u540d\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;line-height:150%;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009548\" data-ratio=\"1.1903190319031902\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_8V0n9vkQ3FlxicxE8GFxr4SvHEfBUQ-1.png?resize=553%2C658\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx40DbJKKXHudTS1E95gfxweml8HqiaDMMTJibkfoJfVklLFwas8V0n9vkQ3FlxicxE8GFxr4SvHEfBUQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"909\" height=\"658 .5900268554688\" width=\"553 .2899780273438\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">Figure 3. Association of DDR expression with TME features and immune checkpoint therapy response in human BCa<\/span><\/p>\n<p style=\"mso-list:l0 level1 lfo1;margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;margin-left:0.0pt;text-indent:0.0pt;line-height:150%;\"><span style=\"color: rgb(0, 82, 255);font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">4.DDR\u9a71\u52a8\u7684\u57fa\u56e0\u7b7e\u540d\u7684\u53d1\u5c55<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-indent:24.0pt;mso-char-indent-count:2.0;mso-char-indent-size:12.0;line-height:150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4f5c\u8005\u5229\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">GSEA<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u5206\u6790DDR1\u548cDDR2\u5206\u7ec4\u5728<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">IMvigor210<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u6570\u636e\u96c6\u4e2d\u7684<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">KEGG<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u901a\u8def\u5bcc\u96c6\u3002\u5e76\u7edf\u8ba1\u4e0d\u540c\u5206\u5b50\u4e9a\u578b\u4e2dDDR1\u548cDDR2\u9ad8\u5206\u7ec4\u7684\u6837\u672c\u5206\u5e03\u3002\u7814\u7a76\u53d1\u73b0<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">DDR2<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u5206\u7ec4\u5bcc\u96c6\u514d\u75ab\u76f8\u5173\u901a\u8def\uff0cDDR1<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u5206\u7ec4\u5bcc\u96c6\u4ee3\u8c22\u901a\u8def\u3002LumP\u548cBa\/Sq \u4e9a\u578b\u4e2dDDR1\/2\u9ad8\u5206\u7ec4\u6837\u672c\u8f83\u591a\u3002<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4ee5\u4e0a\u7ed3\u679c\u8868\u660e\u57fa\u4e8eDDR\u7684\u8868\u8fbe\u7b7e\u540d\u53ef\u4ee5\u53cd\u6620\u514d\u75ab\u5fae\u73af\u5883\u7279\u5f81\u548c\u80bf\u7624\u5206\u5b50\u4e9a\u578b\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009545\" data-ratio=\"1.1417410714285714\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_C6M8NRzlBxcywvKnC5btTyWOKAt4Dw-1.png?resize=553%2C632\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx40DbJKKXHudTS1E95gfxwe8icG4ndTQRtk83gONs3qQfibTQC6M8NRzlBxcywvKnC5btTyWOKAt4Dw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"896\" height=\"632 .219970703125\" width=\"553 .739990234375\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">Figure 4. Relationship of DDR gene signature scores with molecular pathways and tumor subtypes in bladder cancer<\/span><\/p>\n<p style=\"mso-list:l0 level1 lfo1;margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;margin-left:0.0pt;text-indent:0.0pt;line-height:150%;\"><span style=\"color: rgb(0, 82, 255);\"><span style=\"font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">5.<\/span><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u8bc4\u4ef7DDR\u7b7e\u540d\u8bc4\u5206\u4f5c\u4e3a\u60a3\u8005\u6297PD-L1\u53cd\u5e94\u7684\u9884\u6d4b\u56e0\u7d20<\/span><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-indent:24.0pt;mso-char-indent-count:2.0;mso-char-indent-size:12.0;line-height:150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4f5c\u8005\u5229\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u7bb1\u7ebf\u56fe<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u6bd4\u8f83\u4e0d\u540c\u6cbb\u7597\u53cd\u5e94\u7ec4\u7684DDR1\u548cDDR2\u8868\u8fbe\u7b7e\u540d\u3002\u5229\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">Kaplan-Meier\u66f2\u7ebf<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u5206\u6790DDR1\u548cDDR2\u5206\u7ec4\u7684\u751f\u5b58\u5dee\u5f02\u3002\u7814\u7a76\u53d1\u73b0<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">DDR1\u548cDDR2\u8868\u8fbe\u7b7e\u540d\u5728\u4e0d\u540c\u6cbb\u7597\u53cd\u5e94\u7ec4\u95f4\u8868\u8fbe\u5dee\u5f02\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002DDR1\u548cDDR2\u7684\u9ad8\u5206\u7ec4\u4e0e\u8f83\u77ed\u7684\u751f\u5b58\u65f6\u95f4\u76f8\u5173\u3002<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4ee5\u4e0a\u7ed3\u679c\u8868\u660e\u57fa\u4e8eDDR\u7684\u8868\u8fbe\u7b7e\u540d\u53ef\u4ee5\u9884\u6d4b\u6297PD-L1\u7684\u6cbb\u7597\u53cd\u5e94\u548c\u60a3\u8005\u751f\u5b58\uff0c\u63d0\u793a\u8fd9\u4e9b\u7b7e\u540d\u5177\u6709\u9884\u6d4b\u4ef7\u503c\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009547\" data-ratio=\"0.7139874739039666\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_Bovz09dZFOib2VMHT4fnhoqn0FLIwA-1.png?resize=553%2C395\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx40DbJKKXHudTS1E95gfxwecc65lM6iagkHfacD327O2fc58zBovz09dZFOib2VMHT4fnhoqn0FLIwA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"958\" height=\"395 .3599853515625\" width=\"553 .72998046875\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">Figure 5. Association of DDR gene signature scores with immune checkpoint therapy response of bladder cancer patients<\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-indent:24.0pt;mso-char-indent-count:2.0;mso-char-indent-size:12.0;line-height:150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4f5c\u8005\u901a\u8fc7\u7edf\u8ba1\u5b66\u7b5b\u9009\u65b9\u6cd5<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u4f18\u5316DDR\u57fa\u56e0\u7b7e\u540d<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u7684\u7ec4\u6210\u3002\u5229\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u751f\u5b58\u5206\u6790<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u786e\u5b9aDDR\u7b7e\u540d\u7684\u6700\u4f73\u622a\u70b9\u3002\u5728\u72ec\u7acb\u7684\u80ba\u764c\u548c\u8180\u80f1\u764c<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u6570\u636e\u96c6<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e2d\u9a8c\u8bc1DDR\u7b7e\u540d\u7684<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u9884\u6d4b\u4ef7\u503c<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u3002<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u7814\u7a76\u901a\u8fc7\u4f18\u5316\u5f97\u5230\u4e86DDR1\u548cDDR2\u7684\u57fa\u56e0\u7b7e\u540d\u6a21\u578b\u3002\u53d1\u73b0DDR\u7b7e\u540d\u53ef\u4ee5\u9884\u6d4b\u5404\u6570\u636e\u96c6\u4e2d\u60a3\u8005\u7684\u751f\u5b58\u3002\u901a\u8fc7\u53cc\u76f2\u9a8c\u8bc1\u786e\u8ba4\u4e86DDR\u7b7e\u540d\u5728\u591a\u79cd\u764c\u75c7\u4e2d\u7684\u9884\u6d4b\u4ef7\u503c\u3002<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u56fe6\u7cfb\u7edf\u5730\u4f18\u5316\u548c\u9a8c\u8bc1\u4e86DDR\u57fa\u56e0\u7b7e\u540d\u7684\u9884\u6d4b\u80fd\u529b\uff0c\u4f7f\u8fd9\u79cd\u7b7e\u540d\u65b9\u6cd5\u5177\u6709\u4e86\u66f4\u597d\u7684\u9002\u7528\u6027\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009546\" data-ratio=\"1.2339707536557931\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_owqoGibA9SBl7WY1AwqbNp21ngmdzg-1.png?resize=553%2C683\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx40DbJKKXHudTS1E95gfxwesugEqk2icJZY2Y2ndiaBvg9lIKXowqoGibA9SBl7WY1AwqbNp21ngmdzg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"889\" height=\"683 .0800170898438\" width=\"553 .5599975585938\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">Figure 6. Optimization and validation of DDR gene signature scores as predictors of tumor response to anti\u2013PD-L1 therapy<\/span><\/p>\n<p style=\"margin-top:7.8pt;mso-para-margin-top:0.5gd;margin-bottom:7.8pt;mso-para-margin-bottom:0.5gd;text-align:center;line-height:150%;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/p>\n<p style=\"line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u8fd9\u662f\u7b2c\u4e00\u4e2a\u5229\u7528DDR\u57fa\u56e0\u5bb6\u65cf\u7684\u5dee\u5f02\u8868\u8fbe\u548c\u8c03\u63a7\u6a21\u5f0f\u6765\u9884\u6d4b\u6cbb\u7597\u53cd\u5e94\u7684\u6587\u7ae0\u3002\u7814\u7a76\u53d1\u73b0DDR1<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u8868\u8fbe\u4e0e\u975eT\u7ec6\u80de\u6d78\u6da6\u7684\u514d\u75ab\u201c\u51b7\u201d\u80bf\u7624\u76f8\u5173\uff0c\u800cDDR2<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>high<\/sup><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u8868\u8fbe\u4e0eT\u7ec6\u80de\u6d78\u6da6\u7684\u514d\u75ab\u201c\u70ed\u201d\u80bf\u7624\u76f8\u5173\u3002\u7814\u7a76\u5f00\u53d1\u4e86\u57fa\u4e8eDDR1\u548cDDR2\u7684\u7279\u5f02\u6027\u57fa\u56e0\u8868\u8fbe\u7b7e\u540d\uff0c\u53ef\u4ee5\u533a\u5206\u4e0d\u540c\u7684\u514d\u75ab\u5fae\u73af\u5883\u548c\u9884\u6d4b\u60a3\u8005\u9884\u540e\u3002\u4e0d\u4ec5\u5728\u8180\u80f1\u764c\u4e2d\u53d1\u73b0\u4e86\u8fd9\u4e00\u9884\u540e\u9884\u6d4b\u4ef7\u503c\uff0c\u8fd8\u901a\u8fc7\u72ec\u7acb\u6570\u636e\u96c6\u8bc1\u5b9e\u4e86\u8fd9\u4e00\u7b7e\u540d\u5728\u591a\u79cd\u5b9e\u4f53\u7624\u4e2d\u7684\u901a\u7528\u6027\u3002\u8fd9\u4e3aDDR\u6291\u5236\u5242\u8054\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u63d0\u4f9b\u4e86\u7406\u8bba\u4f9d\u636e\u548c\u4e34\u5e8a\u8f6c\u6362\u65b9\u5411\uff0c\u6307\u5bfc\u540e\u7eed\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u3002\u7814\u7a76\u8fd8\u91c7\u7528\u4e86\u72ec\u7279\u7684\u53cc\u76f2\u9a8c\u8bc1\u65b9\u6cd5\u8bc1\u660e\u57fa\u56e0\u7b7e\u540d\u9884\u6d4b\u4ef7\u503c\u7684\u53ef\u9760\u6027\u3002<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#4F81BD;font-weight:bold;mso-bidi-font-weight:bold;\">\u6709\u8fdb\u4e00\u6b65\u9700\u8981\u7684\u670b\u53cb\u4eec\u53ef\u4ee5\u627e\u9986\u957f\u505a\u8bbe\u8ba1\u54e6\uff01\u9986\u957f\u80fd\u4ece\u7814\u7a76\u65b9\u5411\u548c\u601d\u8def\u65b9\u6cd5\u4e0a\u63d0\u4f9b\u5168\u65b9\u4f4d\u7684\u6307\u5bfc\u3002<\/span><\/p>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017409\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_B2jkicacLzPjw4xMSqVvoucZjonVDA-1.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017410\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/14_7TvAyUibd1TPhJmZfialJtv6tu2SEg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100017411\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/15_9N02aBaau07RufXeXRLmvAHsrFZxtw-1.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;text-wrap: wrap;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;margin-bottom: 0px;\"><br \/><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<p style=\"display: none;margin-bottom: 24px;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u521b\u65b0\u597d\u590d\u73b0\u7684\u7eaf\u751f\u4fe1\u601d\u8def\uff01PD-L1+\u751f\u7269\u6807\u5fd7\u7269+\u9884\u540e\u6a21\u578b\u89e3\u950115+\uff01 \u9986\u957f  \u751f\u4fe1\u679c&nb […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/51235"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=51235"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/51235\/revisions"}],"predecessor-version":[{"id":51277,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/51235\/revisions\/51277"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=51235"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=51235"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=51235"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}