{"id":52521,"date":"2024-06-16T11:32:58","date_gmt":"2024-06-16T03:32:58","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=52521"},"modified":"2024-06-16T11:32:58","modified_gmt":"2024-06-16T03:32:58","slug":"%e6%80%a7%e4%bb%b7%e6%af%94%e4%b9%8b%e7%8e%8b%ef%bc%813%e5%9b%be0%e5%ae%9e%e9%aa%8c%e6%8b%bf%e4%b8%8bsci%e5%8c%bb%e5%ad%a61%e5%8c%ba%ef%bc%81%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=52521","title":{"rendered":"\u6027\u4ef7\u6bd4\u4e4b\u738b\uff013\u56fe0\u5b9e\u9a8c\u62ff\u4e0bSCI\u533b\u5b661\u533a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u8054\u5408\u591a\u79cd\u9057\u4f20\u5b66\u65b9\u6cd5\u7814\u7a76\uff0c\u4ec5\u7528\u6570\u636e\u5206\u6790\u4e5f\u80fd\u8f7b\u677e\u4e0a8+\uff01"},"content":{"rendered":"


\n
\n<\/title><br \/>\n<meta charset=\"utf-8\"><br \/>\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,maximum-scale=1.0,user-scalable=0,viewport-fit=cover\"><\/p>\n<style>\n*{margin:0;padding:0}html{-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;line-height:1.6}img{z-index:999;position:relative;max-width:100%;margin:10px 0;}body{letter-spacing:.034em}h1,h2,h3,h4,h5,h6{font-weight:400;font-size:16px}a{color:#576b95;text-decoration:none;-webkit-tap-highlight-color:rgba(0,0,0,0)}td,th{word-wrap:break-word;padding:5px 10px;border:1px solid #DDD;}table{margin-bottom:10px;border-collapse:collapse;display:table;width:100%!important;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}.rich_media_area_primary{padding:20px 16px 12px;background-color:#fafafa}@media (max-width:375px){.rich_media_area_primary{padding:20px 60px 15px 60px}.rich_media_area_extra{padding:0 60px 21px 60px}}@media (min-width:1024px){.rich_media_area_primary_inner,.rich_media_area_extra_inner,body{max-width:677px;margin-left:auto;margin-right:auto}.rich_media_area_primary{padding-top:32px}}.rich_media{padding:20px;overflow:hidden;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}@media screen and (min-width:1024px){.rich_media_area_primary_inner,.rich_media_area_extra_inner{max-width:677px;margin-left:auto;margin-right:auto}.rich_media_area_primary{padding-top:32px}}.rich_media_content{overflow:hidden;color:#333;font-size:17px;word-wrap:break-word;-webkit-hyphens:auto;-ms-hyphens:auto;hyphens:auto;text-align:justify;position:relative;z-index:0}.rich_media_content *{max-width:100%!important;box-sizing:border-box!important;-webkit-box-sizing:border-box!important;word-wrap:break-word!important}.rich_media_content p{clear:both;min-height:1em}.rich_media_content em{font-style:italic}.rich_media_content fieldset{min-width:0}.rich_media_content .list-paddingleft-1,.rich_media_content .list-paddingleft-2,.rich_media_content .list-paddingleft-3{padding-left:2.2em}.rich_media_content .list-paddingleft-1 .list-paddingleft-2,.rich_media_content .list-paddingleft-2 .list-paddingleft-2,.rich_media_content .list-paddingleft-3 .list-paddingleft-2{padding-left:30px}.rich_media_content .list-paddingleft-1{padding-left:1.2em}.rich_media_content .list-paddingleft-3{padding-left:3.2em}.rich_media_content .code-snippet,.rich_media_content .code-snippet__fix{max-width:1000%!important}.rich_media_content .code-snippet *,.rich_media_content .code-snippet__fix *{max-width:1000%!important}.rich_media_title{font-size:22px;line-height:1.4;margin-bottom:13px;padding-bottom:13px;border-bottom:1px solid #e7e7eb;}@supports(-webkit-overflow-scrolling:touch){.rich_media_title{font-weight:700}}.rich_media_meta{display:inline-block;vertical-align:middle;padding:0 0 10px 0;font-size:15px;-webkit-tap-highlight-color:rgba(0,0,0,0)}.rich_media_meta.icon_appmsg_tag{margin-right:0px}.rich_media_meta.meta_tag_text{margin-right:0}.rich_media_meta_list em{font-style:normal}.rich_media_meta_text{color:#a5a5a5;}p{margin:0;}.msgBox{margin-top:20px;padding-top:20px;padding-left:50px;overflow:hidden;border-top:2px dashed #09a2ff;}.msg{padding-top:7px;clear:both;}.msgBody{float:right;width:100%;margin-left:55px;padding-bottom:15px;border-bottom:1px dashed #e0e0e0;}.userHeadImg{float:left;margin-left:-50px;}.userHeadImg img{width:40px;height:40px;margin-right:10px;border-radius:3px;}.userName{color:#888888;line-height:24px;font-size:14px;margin:5px 0 5px 0;height:24px;}.replyBody,.autherBody{color:#565656;font-size:15px;}.replyIcon{border-left:4px solid #33ab01;margin-right:5px;}.ad{text-decoration:none;color:#d6d4d4;font-size:12px;}.msgBodyReply{padding-top:5px;}.userName span{float:right;color:#afafaf;font-size:14px;}code{text-align:left;font-size:14px;display:block;white-space:pre;display:-webkit-box;display:-webkit-flex;display:flex;position:relative;}.code-snippet__fix{font-size:14px;margin:10px 0;display:block;color:#333;position:relative;background-color:rgba(0,0,0,0.03);border:1px solid #f0f0f0;border-radius:2px;display:-webkit-box;display:-webkit-flex;display:flex;padding-left:25px;line-height:26px}.code-snippet__fix code{text-align:left;font-size:14px;display:block;white-space:pre;display:-webkit-box;display:-webkit-flex;display:flex;position:relative;font-family:Consolas,\"Liberation Mono\",Menlo,Courier,monospace}.code-snippet__comment,.code-snippet__quote{color:#afafaf;font-style:italic}.code-snippet__keyword,.code-snippet__selector-tag,.code-snippet__subst{color:#ca7d37}.code-snippet__number,.code-snippet__literal,.code-snippet__variable,.code-snippet__template-variable,.code-snippet__tag .code-snippet__attr{color:#0e9ce5}.code-snippet__string,.code-snippet__doctag{color:#d14}.code-snippet__title,.code-snippet__section,.code-snippet__selector-id{color:#d14}.code-snippet__subst{font-weight:normal}.code-snippet__type,.code-snippet__class .code-snippet__title{color:#0e9ce5}.code-snippet__tag,.code-snippet__name,.code-snippet__attribute{color:#0e9ce5;font-weight:normal}.code-snippet__regexp,.code-snippet__link{color:#ca7d37}.code-snippet__symbol,.code-snippet__bullet{color:#d14}.code-snippet__built_in,.code-snippet__builtin-name{color:#ca7d37}.code-snippet__meta{color:#afafaf}.code-snippet__deletion{background:#fdd}.code-snippet__addition{background:#dfd}.code-snippet__emphasis{font-style:italic}.code-snippet__strong{font-weight:bold}.account_avatar{width:40px;height:40px;padding:0;}.account_info{display:-webkit-box;display:-webkit-flex;display:flex;-webkit-box-align:center;-webkit-align-items:center;padding:20px 0;align-items:center}.flex_bd{padding-left:14px;}.account_nickname{display:inline-block;vertical-align:middle;line-height:1.2;color:#576b95;font-size:14px}.account_desc{overflow:hidden;text-overflow:ellipsis;display:-webkit-box;-webkit-box-orient:vertical;-webkit-line-clamp:1;color:rgba(0,0,0,0.3);font-size:14px;line-height:1.2;padding-top:.4em}.msg_source_url{text-align:left;word-break:break-all;margin-top:20px;}.msg_source_url a{padding-right:10px;}.msg_source_url .url_text{color:#a8a8a8;}.video-desc{font-size:14px;margin-top:15px;color:#6c6c6c;}.msg_source_url{text-align:left;}.original_primary_card_tips{color:rgba(0,0,0,0.3);line-height:1.4;font-size:15px;}.weui-flex__item{margin-bottom:20px;padding:20px 16px;margin-top:16px;line-height:1.4;align-items:center;background-color:#f7f7f7;border-radius:8px;position:relative;}.original_primary_desc{color:rgba(0,0,0,0.5);font-size:14px;padding-top:4px;width:auto;overflow:hidden;text-overflow:ellipsis;}.msgBodyReplyList{border-top:1px solid #e1e1e1;margin-top:10px;}.msgBodyReplyListTop{border-top:0;}.reply_like_num{float:right;font-size:14px;color:#c7c7c7;}.msgData{margin-top:20px;color:#626262;}.msgData span{font-size:14px;padding-right:15px;}.msgData .likes{float:right;padding-right:0;}.js_text_content p{font-size:18px;}.rich_media_meta_link{font-size:15px;}blockquote {padding-left: 10px;border-left: 3px solid #dbdbdb;color: rgba(0,0,0,0.5);font-size: 15px;padding-top: 4px;margin: 1em 0;}.video_iframe{width:500px;height:400px;}.blockquote_info{color:#b5b5b5;margin-top:10px;}#copyright_logo{color:#bdbdbd;}.rich_media_meta_list{margin-bottom:10px;}.reprint{background:#efefef;border-radius:5px;padding:8px;color:#1f1f1f;}.reprint a{word-break:break-all;}.topic{color:#8e8e8e;background:#f7f7f7;border-radius:5px;padding:10px 8px;}.topic a{padding-right:5px;}.topic p{margin-bottom:5px;}\n<\/style>\n<link href=\"https:\/\/www.juyifx.cn\/config\/css\/wxArticle.css\" rel=\"stylesheet\"\/>\n<\/head><script>\nvar data={\"mp\":\"\u751f\u4fe1\u679c\",\"title\":\"\u6027\u4ef7\u6bd4\u4e4b\u738b\uff013\u56fe0\u5b9e\u9a8c\u62ff\u4e0bSCI\u533b\u5b661\u533a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u8054\u5408\u591a\u79cd\u9057\u4f20\u5b66\u65b9\u6cd5\u7814\u7a76\uff0c\u4ec5\u7528\u6570\u636e\u5206\u6790\u4e5f\u80fd\u8f7b\u677e\u4e0a8+\uff01\",\"time\":\"2024-03-18 19:02:32\",\"timeStamp\":\"1710759752\"};\n<\/script><br \/>\n<body><\/p>\n<div class=\"rich_media\">\n<h1 class=\"rich_media_title\" id=\"activity-name\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247501049&idx=1&sn=f8999a1fe1d3bf10430c2b20504392c2&chksm=cf7f543cf808dd2aef0956eeb52cecc123ede0e71658244f6fc92595b619c54edc9f90edd9c5#rd\" target=\"_blank\" rel=\"noopener\">\u6027\u4ef7\u6bd4\u4e4b\u738b\uff013\u56fe0\u5b9e\u9a8c\u62ff\u4e0bSCI\u533b\u5b661\u533a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u8054\u5408\u591a\u79cd\u9057\u4f20\u5b66\u65b9\u6cd5\u7814\u7a76\uff0c\u4ec5\u7528\u6570\u636e\u5206\u6790\u4e5f\u80fd\u8f7b\u677e\u4e0a8+\uff01<\/a><\/h1>\n<div id=\"meta_content\" class=\"rich_media_meta_list\"><span class=\"rich_media_meta rich_media_meta_text\">\u9986\u957f  <\/span><span class=\"rich_media_meta rich_media_meta_nickname\" id=\"profileBt\"><a href=\"javascript:void(0);\" class=\"wx_tap_link js_wx_tap_highlight weui-wa-hotarea\" id=\"js_name\">\u751f\u4fe1\u679c  <\/a><\/span><em id=\"publish_time\" class=\"rich_media_meta rich_media_meta_text\">2024-03-18 19:02:32<\/em><\/div>\n<p><content><\/p>\n<div class=\"reprint\">\n<p>\u8f6c\u81ea\u516c\u4f17\u53f7\uff1a\u751f\u4fe1\u56fe\u4e66\u9986<br \/><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkzNjQ2NzE3Mg==&mid=2247493068&idx=1&sn=8670ab4a3dee1918e0009a730d5e1383\" target=\"_blank\" title=\"\u9605\u8bfb\u539f\u6587\" rel=\"noopener\">http:\/\/mp.weixin.qq.com\/s?__biz=MzkzNjQ2NzE3Mg==&mid=2247493068&idx=1&sn=8670ab4a3dee1918e0009a730d5e1383<\/a><\/p>\n<\/div>\n<p style=\"text-align: center;\" data-mpa-powered-by=\"yiban.io\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100015224\" data-ratio=\"0.2222222222222222\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_r0Gd7iaumIGMiaia97aHFV15nrpdzw-69.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxQW8Zek7Noib2uBhB3ZE3yMxI2Hfic7cGTdPYiacicg47jficdr5BVr0Gd7iaumIGMiaia97aHFV15nrpdzw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"900\" style=\"\"><\/p>\n<p style=\"line-height: 150%;margin-bottom: 24px;\"><span style=\"font-family: \u5b8b\u4f53;font-size: 12pt;letter-spacing: 0.034em;\">\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u5e7f\u9614\u7814\u7a76\u9886\u57df\u4e2d\uff0c\u5171\u75c5\u673a\u5236\u7684\u7814\u7a76\u4e00\u76f4\u90fd\u662f\u9690\u85cf\u7684\u5bc6\u7801\uff0c\u7b49\u5f85\u7740\u88ab\u89e3\u7801\u3002\u5355\u4e00\u9057\u4f20\u7814\u7a76\u3001\u4f20\u7edfGWAS\u5206\u6790\u5728\u63a2\u7a76ALS\u548cPD\u7b49\u590d\u6742\u75be\u75c5\u65f6\uff0c\u603b\u662f\u5b58\u5728\u79cd\u79cd\u5c40\u9650\uff0c\u9650\u5236\u7814\u7a76\u7684\u6df1\u5ea6\u548c\u5e7f\u5ea6\u3002\u800c\u591a\u65b9\u6cd5\u7efc\u5408\u5206\u6790\u5219\u642d\u8f7d\u7740\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u8f6c\u5f55\u7ec4\u5173\u8054\u7814\u7a76\uff08TWAS\uff09\u7b49\u591a\u79cd\u5148\u8fdb\u4eea\u5668\uff0c\u8f7b\u677e\u6355\u6349\u5f71\u54cd\u75be\u75c5\u8f68\u8ff9\u7684\u5173\u952e\u57fa\u56e0\u548c\u901a\u8def\uff0c\u6b63\u9010\u6b65\u6210\u4e3a\u65e0\u6570\u79d1\u7814\u5b66\u8005\u7684\u79d8\u5bc6\u6b66\u5668\uff01<\/span><br \/><\/p>\n<p style=\"line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u4eca\u5929\u9986\u957f\u4e3a\u5927\u5bb6\u5e26\u6765\u4e86\u4e00\u7bc7IF=8.6\u7684\u6587\u7ae0\uff0c\u9075\u5faa\u4ece\u5b8f\u89c2\u5230\u5fae\u89c2\u7684\u7814\u7a76\u601d\u8def\uff0c\u5de7\u5999\u5730\u8fd0\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u548c\u8f6c\u5f55\u7ec4<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u5173\u8054\u7814\u7a76\uff0c\u63ed\u793a\u4e86\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u548c\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u4e4b\u95f4\u9690\u79d8\u7684\u9057\u4f20\u7ebd\u5e26\uff0c\u4e3a\u7406\u89e3\u5b83\u4eec\u7684\u590d\u6742\u4ea4\u7ec7\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u3002<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;\">\u8fd9\u7bc7\u6587\u7ae0\u8bbe\u8ba1\u4e25\u8c28\u7f1c\u5bc6\u3001\u601d\u8def\u7cbe\u5999\u7edd\u4f26\uff0c\u5b66\u4f1a\u73a9\u8f6c\u5404\u79cd\u9057\u4f20\u5b66\u65b9\u6cd5\uff0c\u4e0d\u505a\u5b9e\u9a8c\u7eaf\u751f\u4fe1\uff0c\u4e5f\u80fd\u8f7b\u677e\u53d1\u88688\u5206+\uff01\u8ddf\u9986\u957f\u4e00\u8d77\u6765\u63ed\u79d8\u5427\uff5e<\/span><\/p>\n<p style=\"line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">1\u3001\u672c\u7814\u7a76\u805a\u7126\u4e8e\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u5171\u75c5\u673a\u5236\uff0c<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;\">\u9996\u6b21<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u63ed\u793a\u4e86ALS\u548cPD\u4e24\u79cd\u75be\u75c5\u4e4b\u95f4\u6f5c\u5728\u7684\u9057\u4f20\u8054\u7cfb\uff0c\u5305\u62ec\u4e8c\u8005\u9057\u4f20\u76f8\u5173\u6027\u3001\u56e0\u679c\u5173\u7cfb\u3001\u5171\u75c5\u57fa\u56e0\u7684\u8bc6\u522b\u4ee5\u53ca\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\u7684\u5206\u6790\uff0c\u4e3a\u7406\u89e3\u4e24\u79cd\u75be\u75c5\u7684\u5171\u75c5\u673a\u5236\u63d0\u4f9b\u4e86\u5168\u9762\u7684\u89c6\u89d2\u3002<\/span><\/p>\n<p style=\"line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">2\u3001\u672c\u7814\u7a76\u8fd0\u7528<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;\">\u591a\u79cd\u5148\u8fdb\u7684\u9057\u4f20\u5b66\u7814\u7a76\u65b9\u6cd5<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\uff0c\u5305\u62ec\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u3001\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u3001\u591a\u6027\u72b6\u5206\u6790\uff08MTAG\uff09\u3001\u8de8\u8868\u578b\u5173\u8054\uff08CPASSOC\uff09\u4ee5\u53ca\u8f6c\u5f55\u7ec4\u5173\u8054\u7814\u7a76\uff08TWAS\uff09\u7b49\uff0c\u4e3a\u7814\u7a76\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u6280\u672f\u57fa\u7840\u3002<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#FF0000;font-weight:bold;\">\uff08ps\uff1a\u9986\u957f\u8fd9\u91cc\u8fd8\u6709\u5176\u4ed6\u7684\u65b0\u9896\u7684\u79d1\u7814\u70ed\u70b9\u65b9\u5411\uff0c\u800c\u4e14\u80fd\u63d0\u4f9b\u7279\u8272\u6570\u636e\u5e93\u6784\u5efa\u3001\u514d\u8d39\u601d\u8def\u8bc4\u4f30\u3001\u4ed8\u8d39\u751f\u4fe1\u5206\u6790\u7b49\u670d\u52a1\uff0c\u5c0f\u4f19\u4f34\u4eec\u626b\u7801call\u6211\u5427\uff5e\uff09<\/span><span style=\"font-family: \u5b8b\u4f53;font-size: 12pt;letter-spacing: 0.034em;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017362\" data-ratio=\"1\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-18.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 191px;height: 191px;\" \/><span style=\"font-size: var(--articleFontsize);letter-spacing: 0.034em;text-align: justify;\">   <\/span><\/p>\n<p style=\"line-height: 150%;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009406\" data-ratio=\"0.5555555555555556\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_HtugjhNhuKEed0fFZsRmjqHWuAGyIA-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx4C9qib1q8DPVibEhO83eZ0YjgOrR35bUEYIGd0Q7Aibrnb7oCHtugjhNhuKEed0fFZsRmjqHWuAGyIA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"990\" height=\"307.6000061035156\" style=\"height: auto !important;\" width=\"553.739990234375\" \/><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"margin-top: 0.0pt;margin-bottom: 0.0pt;text-align: justify;text-justify: inter-ideograph;mso-pagination: none;font-size: 10.5pt;mso-bidi-font-size: 11.0pt;font-family: \u7b49\u7ebf;mso-fareast-font-family: '\u7b49\u7ebf';mso-font-kerning: 1.0pt;font-weight: normal;mso-bidi-font-weight: normal;mso-list: l1 level1 lfo1;margin-left: 21.0pt;text-indent: -21.0pt;mso-char-indent-count: 0;mso-char-indent-size: 0pt;line-height: 150%;\"><span style=\"font-family:Wingdings;mso-ascii-font-family:Wingdings;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#ED7D31;\">l<span style=\"font:7.0pt Times New Roman;\"><\/span><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u9898\u76ee\uff1a\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u548c\u5e15\u91d1\u68ee\u75c5\u7684\u5171\u540c\u9057\u4f20\u548c\u5408\u5e76\u57fa\u56e0<\/span><\/p>\n<p style=\"margin-top: 0.0pt;margin-bottom: 0.0pt;text-align: justify;text-justify: inter-ideograph;mso-pagination: none;font-size: 10.5pt;mso-bidi-font-size: 11.0pt;font-family: \u7b49\u7ebf;mso-fareast-font-family: '\u7b49\u7ebf';mso-font-kerning: 1.0pt;font-weight: normal;mso-bidi-font-weight: normal;mso-list: l1 level1 lfo1;margin-left: 21.0pt;text-indent: -21.0pt;mso-char-indent-count: 0;mso-char-indent-size: 0pt;line-height: 150%;\"><span style=\"font-family:Wingdings;mso-ascii-font-family:Wingdings;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#ED7D31;\">l<span style=\"font:7.0pt Times New Roman;\"><\/span><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u6742\u5fd7\uff1aMovement Disorders<\/span><\/p>\n<p style=\"margin-top: 0.0pt;margin-bottom: 0.0pt;text-align: justify;text-justify: inter-ideograph;mso-pagination: none;font-size: 10.5pt;mso-bidi-font-size: 11.0pt;font-family: \u7b49\u7ebf;mso-fareast-font-family: '\u7b49\u7ebf';mso-font-kerning: 1.0pt;font-weight: normal;mso-bidi-font-weight: normal;mso-list: l1 level1 lfo1;margin-left: 21.0pt;text-indent: -21.0pt;mso-char-indent-count: 0;mso-char-indent-size: 0pt;line-height: 150%;\"><span style=\"font-family:Wingdings;mso-ascii-font-family:Wingdings;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#ED7D31;\">l<span style=\"font:7.0pt Times New Roman;\"><\/span><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=8.6<\/span><\/p>\n<p style=\"margin-top: 0.0pt;margin-bottom: 0.0pt;text-align: justify;text-justify: inter-ideograph;mso-pagination: none;font-size: 10.5pt;mso-bidi-font-size: 11.0pt;font-family: \u7b49\u7ebf;mso-fareast-font-family: '\u7b49\u7ebf';mso-font-kerning: 1.0pt;font-weight: normal;mso-bidi-font-weight: normal;mso-list: l1 level1 lfo1;margin-left: 21.0pt;text-indent: -21.0pt;mso-char-indent-count: 0;mso-char-indent-size: 0pt;line-height: 150%;\"><span style=\"font-family:Wingdings;mso-ascii-font-family:Wingdings;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#ED7D31;\">l<span style=\"font:7.0pt Times New Roman;\"><\/span><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e7410\u6708<\/span><\/p>\n<p style=\"margin-top: 0.0pt;margin-bottom: 0.0pt;text-align: justify;text-justify: inter-ideograph;mso-pagination: none;font-size: 10.5pt;mso-bidi-font-size: 11.0pt;font-family: \u7b49\u7ebf;mso-fareast-font-family: '\u7b49\u7ebf';mso-font-kerning: 1.0pt;font-weight: normal;mso-bidi-font-weight: normal;mso-list: l1 level1 lfo1;margin-left: 21.0pt;text-indent: -21.0pt;mso-char-indent-count: 0;mso-char-indent-size: 0pt;line-height: 150%;\"><br \/><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"margin-top: 0.0pt;margin-bottom: 0.0pt;text-align: justify;text-justify: inter-ideograph;mso-pagination: none;font-size: 10.5pt;mso-bidi-font-size: 11.0pt;font-family: \u7b49\u7ebf;mso-fareast-font-family: '\u7b49\u7ebf';mso-font-kerning: 1.0pt;font-weight: normal;mso-bidi-font-weight: normal;mso-list: l1 level1 lfo1;margin-left: 21.0pt;text-indent: -21.0pt;mso-char-indent-count: 0;mso-char-indent-size: 0pt;line-height: 150%;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\"><br \/><\/span><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u7814\u7a76\u80cc\u666f<\/span><\/p>\n<p style=\"text-align: justify;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">ALS\u662f\u4e00\u79cd\u81f4\u547d\u7684\u8fd0\u52a8\u795e\u7ecf\u5143\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f\u808c\u8089\u63a7\u5236\u7684\u9010\u6e10\u4e27\u5931\u3002PD\u5219\u662f\u4e00\u79cd\u4e0d\u53ef\u6cbb\u6108\u7684\u795e\u7ecf\u9000\u884c\u6027\u8fd0\u52a8\u969c\u788d\uff0c\u5176\u4e3b\u8981\u75c7\u72b6\u5305\u62ec\u50f5\u786c\u3001\u9759\u6b62\u6027\u9707\u98a4\u548c\u8fd0\u52a8\u8fdf\u7f13\u3002\u5c3d\u7ba1\u8fd9\u4e24\u79cd\u75be\u75c5\u5728\u4e34\u5e8a\u4e0a\u88ab\u89c2\u5bdf\u5230\u6709\u5171\u75c5\u73b0\u8c61\uff0c\u5373ALS\u60a3\u8005\u5728PD\u53d1\u75c5\u65f6\u53ef\u80fd\u51fa\u73b0\uff0c\u4e14\u7ea630%\u7684ALS\u60a3\u8005\u8868\u73b0\u51faPD\u7684\u65e9\u671f\u75c7\u72b6\uff0c\u5982\u50f5\u786c\u548c\u9759\u6b62\u6027\u9707\u98a4\uff0c\u4f46\u5173\u4e8e\u9057\u4f20\u56e0\u7d20\u5728\u8fd9\u79cd\u5171\u75c5\u6027\u4e2d\u6240\u626e\u6f14\u89d2\u8272\u7684\u4e86\u89e3\u4ecd\u7136\u6709\u9650\u3002<\/span><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u7814\u7a76\u601d\u8def<\/span>    <o:page><\/o:page><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009405\" data-ratio=\"1.3603411513859276\" data-type=\"png\" data-w=\"469\" height=\"638.0999755859375\" width=\"469.07000732421875\" style=\"height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_a17BZ3GAQuHIeTOYfxMXwmIY4tMRbQ-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx4C9qib1q8DPVibEhO83eZ0YjGRPnGujq6xHK7ntbuibZdUJyEia17BZ3GAQuHIeTOYfxMXwmIY4tMRbQ\/640?wx_fmt=png'\" \/><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><\/span><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u6570\u636e\u6765\u6e90<\/span><\/p>\n<p style=\"margin-top: 0pt;margin-bottom: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;margin-left: 21pt;text-indent: -21pt;line-height: 150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:Wingdings;mso-ascii-font-family:Wingdings;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">l<span style=\"font:7.0pt Times New Roman;\"><\/span><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">GWAS\u6570\u636e\uff1a\u6765\u81eaMRC IEU OpenGWAS\u6570\u636e\u5e93\u7684PD GWAS\u6570\u636e\uff0833,674\u75c5\u4f8b\u548c449,056\u5bf9\u7167\uff09\u4ee5\u53caGWAS Catalog\u7684ALS GWAS\u6570\u636e\uff0827,205\u75c5\u4f8b\u548c110,881\u5bf9\u7167\uff09\u3002<\/span><\/p>\n<p style=\"margin-top: 0pt;margin-bottom: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;margin-left: 21pt;text-indent: -21pt;line-height: 150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:Wingdings;mso-ascii-font-family:Wingdings;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">l<span style=\"font:7.0pt Times New Roman;\"><\/span><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u53c2\u8003\u9762\u677f\u548c\u6ce8\u91ca\u6570\u636e\uff1a1000 Genomes Project\u7684\u6b27\u6d32\u8840\u7edf\u6570\u636e\u4f5c\u4e3aLDSC\u548cMR\u5206\u6790\u7684\u53c2\u8003\u9762\u677f\u3002<\/span><\/p>\n<p style=\"margin-top: 0pt;margin-bottom: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;margin-left: 21pt;text-indent: -21pt;line-height: 150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:Wingdings;mso-ascii-font-family:Wingdings;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">l<span style=\"font:7.0pt Times New Roman;\"><\/span><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">TWAS\u5206\u6790\uff1aGTEx v8\u6570\u636e\u63d0\u4f9b\u4e8613\u4e2a\u4e0d\u540c\u8111\u533a\u7ec4\u7ec7\u7684\u8f6c\u5f55\u7ec4\u6570\u636e\uff0ceQTL\u6570\u636e\u4e0eGWAS\u6570\u636e\u7ed3\u5408\u4ee5\u8bc6\u522b\u7ec4\u7ec7\u7279\u5f02\u6027\u57fa\u56e0-\u6027\u72b6\u5173\u8054\u3002<\/span><\/p>\n<p style=\"margin-top: 0.0pt;margin-bottom: 0.0pt;text-justify: inter-ideograph;mso-pagination: none;font-size: 10.5pt;mso-bidi-font-size: 11.0pt;font-family: \u7b49\u7ebf;mso-fareast-font-family: '\u7b49\u7ebf';mso-font-kerning: 1.0pt;font-weight: normal;mso-bidi-font-weight: normal;mso-list: l0 level1 lfo1;text-align: left;margin-left: 21.0pt;text-indent: -21.0pt;mso-char-indent-count: 0;mso-char-indent-size: 0pt;line-height: 150%;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span>    <o:page><\/o:page><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u4e3b\u8981\u7ed3\u679c<\/span><\/p>\n<p style=\"text-align: left;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(255, 251, 0);\">1\u3001PD\u4e0eALS\u4e4b\u95f4\u5b58\u5728\u6b63\u76f8\u5173\u6027\u4e14PD\u5bf9ALD\u6709\u56e0\u679c\u6548\u5e94<\/span><\/p>\n<p style=\"text-align: justify;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u7814\u7a76\u56e2\u961f\u901a\u8fc7\u8fde\u9501\u4e0d\u5e73\u8861\u8bc4\u5206\u56de\u5f52\uff08LDSC\uff09\u548c\u9ad8\u5b9a\u4e49\u4f3c\u7136\uff08HDL\uff09\u65b9\u6cd5\uff0c\u5bf9\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u548c\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u4e4b\u95f4\u7684\u9057\u4f20\u76f8\u5173\u6027\u8fdb\u884c\u4e86\u6df1\u5165\u5206\u6790\u3002\u5229\u7528\u6765\u81eaMRC IEU OpenGWAS\u6570\u636e\u5e93\u7684PD GWAS\u6570\u636e\u548cGWAS Catalog\u7684ALS GWAS\u6570\u636e\uff0c\u53d1\u73b0PD\u4e0eALS\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u7684\u6b63\u76f8\u5173\u6027\uff08rg = 0.144, P = 0.026\uff09\uff0c\u8fd9\u4e00\u7ed3\u679c\u5728HDL\u5206\u6790\u4e2d\u5f97\u5230\u4e86\u8fdb\u4e00\u6b65\u7684\u786e\u8ba4\uff08rg = 0.173, SE = 0.073, PHDL = 0.0176\uff09\u3002\u4e3a\u4e86\u63a2\u7a76\u8fd9\u79cd\u76f8\u5173\u6027\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u7814\u7a76\u8005\u91c7\u7528\u4e86\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u5206\u6790\uff0c\u4f7f\u75281000 Genomes Project Phase 3\uff08\u6b27\u6d32\uff09\u4f5c\u4e3a\u53c2\u8003\u9762\u677f\uff0c\u7b5b\u9009\u51fa\u4e0ePD\u548cALS\u98ce\u9669\u76f8\u5173\u7684\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08SNPs\uff09\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\u3002\u5728\u9006\u65b9\u5dee\u52a0\u6743\uff08IVW\uff09\u5206\u6790\u4e2d\uff0c\u4ed6\u4eec\u53d1\u73b0PD\u7684\u9057\u4f20\u6613\u611f\u6027\u4e0eALS\u98ce\u9669\u7684\u589e\u52a0\u6709\u663e\u8457\u7684\u56e0\u679c\u5173\u8054\uff08OR = 1.09, 95% CI: 1.03\u20131.15, P = 3.00 \u00d7 10^-3\uff09\u3002\u7ecf\u8fc7MR-Egger\u56de\u5f52\u3001\u52a0\u6743\u4e2d\u4f4d\u6570\u65b9\u6cd5\u548cMR-PRESSO\u65b9\u6cd5\u9a8c\u8bc1\uff0c PD\u7684\u9057\u4f20\u6613\u611f\u6027\u786e\u5b9e\u5bf9ALS\u98ce\u9669\u6709\u56e0\u679c\u5f71\u54cd\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009408\" data-ratio=\"0.675\" data-type=\"png\" data-w=\"1080\" height=\"421.0\" width=\"623.8800048828125\" style=\"height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_Zo0IiaMhDwKuPhddh1WHqHkWErBQfA-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx4C9qib1q8DPVibEhO83eZ0YjibvRr6IsPZ73W8ibA0csZWjXgrHZo0IiaMhDwKuPhddh1WHqHkWErBQfA\/640?wx_fmt=png'\" \/><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:10.0pt;line-height:150%;mso-bidi-font-size:10.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u56fe1<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"> ALS\u548cPD\u7684\u9057\u4f20\u76f8\u5173\u6027\u5206\u6790<\/span><span style=\"font-size:10.0pt;line-height:150%;mso-bidi-font-size:10.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"> <\/span><\/p>\n<p style=\"text-align: left;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(255, 251, 0);\">2\u3001\u8bc6\u522bALS\u548cPD\u5171\u6709\u7684\u9057\u4f20\u6807\u5fd7<\/span><\/p>\n<p style=\"text-align: justify;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u91c7\u7528\u591a\u6027\u72b6\u5206\u6790\uff08MTAG\uff09\u548c\u8de8\u8868\u578b\u5173\u8054\uff08CPASSOC\uff09\u65b9\u6cd5\uff0c\u5bf9\u6765\u81ea\u6b27\u6d32\u4eba\u7fa4\u7684\u5927\u89c4\u6a21\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u6570\u636e\u8fdb\u884c\u5206\u6790\uff0c\u7814\u7a76\u8005\u8bc6\u522b\u4e86\u4e5d\u4e2a\u4e0eALS\u548cPD\u98ce\u9669\u76f8\u5173\u7684\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08SNPs\uff09\u3002\u8fd9\u4e9bSNPs\u5173\u8054\u4e8e\u4e09\u4e2a\u67d3\u8272\u4f53\u4e0a\u7684\u98ce\u9669\u4f4d\u70b9\uff084\u300110\u548c17\u53f7\u67d3\u8272\u4f53\uff09\uff0c\u5e76\u4e14\u4e0e\u4e03\u4e2a\u57fa\u56e0\uff08TMEM175, MAPT, NSF, LRRC37A2, ARHGAP27, GAK, \u548c FGFRL1\uff09\u6709\u5173\u8054\u3002\u5728MTAG\u5206\u6790\u4e2d\uff0c\u7814\u7a76\u8005\u53d1\u73b0\u4e862628\u4e2aSNPs\u8fbe\u5230\u4e86\u5168\u57fa\u56e0\u7ec4\u663e\u8457\u6027\u6c34\u5e73\uff08PMTAG < 5 \u00d7 10^-8\uff09\uff0c\u800c\u5728CPASSOC\u5206\u6790\u4e2d\uff0c\u4ed6\u4eec\u4ece3449\u4e2a\u663e\u8457SNPs\u4e2d\u7b5b\u9009\u51fa\u4e8650\u4e2a\u4e0ePD\u548cALS\u5171\u6709\u7684SNPs\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cALS\u548cPD\u4e0d\u4ec5\u5728\u4e34\u5e8a\u8868\u73b0\u4e0a\u5177\u6709\u5171\u75c5\u6027\uff0c\u800c\u4e14\u5b83\u4eec\u5728\u9057\u4f20\u5c42\u9762\u4e0a\u4e5f\u5171\u4eab\u67d0\u4e9b\u98ce\u9669\u4f4d\u70b9\u548c\u57fa\u56e0\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009407\" data-ratio=\"0.3814814814814815\" data-type=\"png\" data-w=\"1080\" height=\"231.3699951171875\" width=\"606.3400268554688\" style=\"height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_m0I7Zcria93icgOvRchmJjOEkP3ONw-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx4C9qib1q8DPVibEhO83eZ0YjtXao8BIsnicSx9zI9j3F1U74vQSm0I7Zcria93icgOvRchmJjOEkP3ONw\/640?wx_fmt=png'\" \/><\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"mso-bookmark:_Hlk157189163;\"><span style=\"font-size:10.0pt;line-height:150%;mso-bidi-font-size:10.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u56fe2 \u591a\u6027\u72b6\u5206\u6790\u4e2d\u53d1\u73b0\u4e0eALS\u548cPD\u98ce\u9669\u76f8\u5173\u7684SNPs<\/span><\/span><\/p>\n<p style=\"text-align: left;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(255, 251, 0);\">3\u3001\u4e0e\u75be\u75c5\u76f8\u5173\u7684\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f<\/span><\/p>\n<p style=\"text-align: justify;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u7814\u7a76\u8005\u91c7\u7528\u4e86\u529f\u80fd\u603b\u7ed3\u57fa\u7840\u7684\u63d2\u8865\uff08FUSION\uff09\u548c\u8054\u5408\u7ec4\u7ec7\u63d2\u8865\uff08JTI\uff09\u6a21\u578b\uff0c\u6574\u5408\u6765\u81ea13\u4e2a\u4e0d\u540c\u8111\u533a\u7684\u57fa\u56e0\u8868\u8fbe\u91cf\u6027\u72b6\u4f4d\u70b9\uff08eQTL\uff09\u6570\u636e\uff0c\u5e76\u4e14\u5bf9GWAS\u6570\u636e\u8fdb\u884c\u4e86\u5206\u6790\u3002\u5728TWAS\u5206\u6790\u4e2d\uff0c\u7814\u7a76\u56e2\u961f\u8bc6\u522b\u4e8693\u4e2a\u901a\u8fc7FUSION\u65b9\u6cd5\u300197\u4e2a\u901a\u8fc7JTI\u65b9\u6cd5\uff0c\u4ee5\u53ca66\u4e2a\u901a\u8fc7\u4e24\u79cd\u65b9\u6cd5\u91cd\u53e0\u7684\u57fa\u56e0\u3002\u5728\u6392\u9664\u4e86PD GWAS TWAS\u4e2d\u7684\u91cd\u590d\u57fa\u56e0\u540e\uff0c\u4ed6\u4eec\u53d1\u73b0\u4e86\u516d\u4e2a\u6f5c\u5728\u7684\u591a\u6548\u6027PD-ALS\u57fa\u56e0\uff0c\u5305\u62ecKANSL1, ARL17B, EFNA1, WNT3, ERCC8, \u548c ADAM15\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u4e9b\u5019\u9009\u57fa\u56e0\u4e3b\u8981\u5bcc\u96c6\u5728\u795e\u7ecf\u5143\u6295\u5c04\u53d1\u5c55\u7684\u8d1f\u5411\u8c03\u63a7\u8fc7\u7a0b\u4e2d\uff0c\u8fd9\u4e00\u53d1\u73b0\u4e0eALS\u548cPD\u7684\u75c5\u7406\u7279\u5f81\u76f8\u543b\u5408\u3002\u4f8b\u5982\uff0cALS\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u795e\u7ecf\u5143\u8f74\u7a81\u7684\u9000\u884c\u6027\u53d8\u5316\uff0c\u4ee5\u53caPD\u4e2d\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u7684\u635f\u5931\uff0c\u90fd\u4e0e\u795e\u7ecf\u5143\u6295\u5c04\u7684\u5f02\u5e38\u53d1\u5c55\u6709\u5173\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u57fa\u56e0\u7684\u8868\u8fbe\u6a21\u5f0f\u53ef\u80fd\u4e0e\u75be\u75c5\u8fdb\u7a0b\u4e2d\u7684\u708e\u75c7\u53cd\u5e94\u3001\u7ebf\u7c92\u4f53\u529f\u80fd\u4ee5\u53ca\u86cb\u767d\u8d28\u805a\u96c6\u7b49\u5173\u952e\u75c5\u7406\u673a\u5236\u76f8\u5173\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009409\" data-ratio=\"0.7212962962962963\" data-type=\"png\" data-w=\"1080\" height=\"422.19000244140625\" width=\"585.6799926757812\" style=\"height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_ZiaDnXU2Y7Xq2aQxYIesFe333eJZHw-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx4C9qib1q8DPVibEhO83eZ0Yj3uibB1EufYQJv7mibviaTIpGibA24ZiaDnXU2Y7Xq2aQxYIesFe333eJZHw\/640?wx_fmt=png'\" \/><\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:10.0pt;line-height:150%;mso-bidi-font-size:10.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u56fe3<\/span><span style=\"font-family:\u7b49\u7ebf;mso-ascii-font-family:\u7b49\u7ebf;mso-fareast-font-family:\u7b49\u7ebf;font-variant:normal;text-transform:none;\"> <\/span><span style=\"font-size:10.0pt;line-height:150%;mso-bidi-font-size:10.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u5206\u6790\u7684\u68ee\u6797\u56fe<\/span><\/p>\n<p style=\"text-align: left;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(255, 251, 0);\">4\u3001\u4e0eALS\u548cPD\u5171\u75c5\u6027\u76f8\u5173\u7684\u57fa\u56e0\u5728\u751f\u7269\u5b66\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528<\/span><\/p>\n<p style=\"text-align: justify;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u901a\u8fc7TWAS\u8bc6\u522b\u4e86\u4e00\u7cfb\u5217\u4e0eALS\u548cPD\u76f8\u5173\u7684\u57fa\u56e0\uff0c\u7136\u540e\u5229\u7528Metascape\u5de5\u5177\u548c\u57fa\u56e0\u4f18\u5148\u7ea7\u901a\u8fc7\u8bc1\u636e\u8ba1\u6570\uff08GPEC\uff09\u65b9\u6cd5\uff0c\u5bf9\u8fd9\u4e9b\u57fa\u56e0\u8fdb\u884c\u4e86\u901a\u8def\u5bcc\u96c6\u5206\u6790\u3002\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u4e0eALS\u548cPD\u5171\u75c5\u6027\u76f8\u5173\u7684\u57fa\u56e0\u4e3b\u8981\u5bcc\u96c6\u5728\u795e\u7ecf\u5143\u6295\u5c04\u53d1\u5c55\u7684\u8d1f\u5411\u8c03\u63a7\uff08GO:0010977\uff09\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\u3002\u7814\u7a76\u56e2\u961f\u8fd8\u53d1\u73b0\uff0c\u8fd9\u4e9b\u5171\u75c5\u57fa\u56e0\u5728\u5176\u4ed6\u751f\u7269\u5b66\u8fc7\u7a0b\u4e2d\u4e5f\u53d1\u6325\u4f5c\u7528\uff0c\u5982\u7ec6\u80de\u8fc7\u7a0b\uff08GO:0009987\uff09\u548c\u751f\u7269\u8fc7\u7a0b\u7684\u8d1f\u5411\u8c03\u63a7\uff08GO:0032502\uff09\u3002\u8fd9\u4e9b\u8fc7\u7a0b\u5728ALS\u548cPD\u7684\u53d1\u75c5\u673a\u5236\u4e2d\u53ef\u80fd\u8d77\u7740\u5173\u952e\u4f5c\u7528\uff0c\u4f8b\u5982\uff0c\u7ec6\u80de\u8fc7\u7a0b\u7684\u5f02\u5e38\u53ef\u80fd\u5bfc\u81f4\u795e\u7ecf\u5143\u529f\u80fd\u969c\u788d\uff0c\u800c\u751f\u7269\u8fc7\u7a0b\u7684\u8d1f\u5411\u8c03\u63a7\u53ef\u80fd\u5f71\u54cd\u795e\u7ecf\u5143\u7684\u751f\u5b58\u548c\u6b7b\u4ea1\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u63ed\u793a\u4e86\u4e0eALS\u548cPD\u76f8\u5173\u7684\u57fa\u56e0\u5728\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\uff0c\u8fd9\u53ef\u80fd\u8868\u660e\u8fd9\u4e9b\u75be\u75c5\u7684\u53d1\u5c55\u4e0e\u65e9\u671f\u795e\u7ecf\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u7684\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\u6709\u5173\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-family:Arial;mso-ascii-font-family:Arial;mso-fareast-font-family:\u7b49\u7ebf;mso-bidi-font-family:Arial;font-variant:normal;text-transform:none;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009410\" data-ratio=\"0.2972222222222222\" data-type=\"jpeg\" data-w=\"1080\" height=\"164.47000122070312\" width=\"553.739990234375\" style=\"height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_PUicrxknrpwuaYgGiaw12AvicbeRAA-3.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx4C9qib1q8DPVibEhO83eZ0Yj06LbIY6Ds4icAYKK6pREIP7rM7iadPUicrxknrpwuaYgGiaw12AvicbeRAA\/640?wx_fmt=jpeg'\" \/><\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:10.0pt;line-height:150%;mso-bidi-font-size:10.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">\u56fe4 \u4e0eALS\u548cPD\u5171\u75c5\u6027\u76f8\u5173\u7684\u57fa\u56e0\u5728\u7279\u5b9a\u901a\u8def\u4e2d\u7684\u5bcc\u96c6\u60c5\u51b5<\/span><\/p>\n<p style=\"text-align: center;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/p>\n<p style=\"text-align: justify;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u672c\u7814\u7a76\u901a\u8fc7\u7efc\u5408\u5206\u6790\u5927\u89c4\u6a21\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u6570\u636e\uff0c\u63ed\u793a\u4e86\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u548c\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u4e4b\u95f4\u7684\u9057\u4f20\u76f8\u5173\u6027\u548c\u5171\u75c5\u673a\u5236\u3002\u7814\u7a76\u56e2\u961f\u8fd0\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08MR\uff09\u5206\u6790\uff0c\u786e\u8ba4\u4e86PD\u5bf9ALS\u98ce\u9669\u7684\u56e0\u679c\u5f71\u54cd\uff0c\u5e76\u901a\u8fc7\u591a\u6027\u72b6\u5206\u6790\uff08MTAG\uff09\u548c\u8de8\u8868\u578b\u5173\u8054\uff08CPASSOC\uff09\u65b9\u6cd5\uff0c\u8bc6\u522b\u4e86\u4e0e\u4e24\u79cd\u75be\u75c5\u5171\u6709\u7684\u9057\u4f20\u6807\u8bb0\u3002\u6b64\u5916\uff0c\u8f6c\u5f55\u7ec4\u5173\u8054\u7814\u7a76\uff08TWAS\uff09\u63ed\u793a\u4e86\u65b0\u7684\u591a\u6548\u6027\u57fa\u56e0\uff0c\u800c\u901a\u8def\u5bcc\u96c6\u5206\u6790\u8fdb\u4e00\u6b65\u9610\u660e\u4e86\u8fd9\u4e9b\u57fa\u56e0\u5728\u795e\u7ecf\u5143\u6295\u5c04\u53d1\u5c55\u8c03\u63a7\u4e2d\u7684\u4f5c\u7528\u3002<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;\">\u8fd9\u7bc7\u6587\u7ae0\u867d\u7136\u4e3b\u8981\u4f9d\u8d56\u4e8e\u73b0\u6709\u7684GWAS\u6570\u636e\uff0c\u53ef\u80fd\u5b58\u5728\u6837\u672c\u6765\u6e90\u7684\u504f\u5dee\uff0c\u4f46\u591a\u79cd\u9057\u4f20\u5b66\u7814\u7a76\u65b9\u6cd5\u7ec4\u5408\u4f9d\u65e7\u80fd\u53d1\u5230IF=8.6\u5206\u6587\u7ae0\uff0c\u6240\u4ee5\u8fd9\u7bc7\u6587\u7ae0\u7684\u601d\u8def\u5c0f\u4f19\u4f34\u4eec\u53ef\u4ee5\u8d76\u5feb\u5b66\u8d77\u6765\uff01<\/span><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;background:#FFFF00;mso-highlight:#FFFF00;\"><\/span><\/p>\n<p style=\"text-align: justify;line-height: 150%;margin-bottom: 24px;\"><span style=\"font-size:12.0pt;line-height:150%;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#FF0000;font-weight:bold;\">\u60f3\u4e86\u89e3\u6700\u8fd1\u7814\u7a76\u70ed\u70b9\u548c\u6295\u7a3f\u77e5\u8bc6\u7684\u5c0f\u4f19\u4f34\u4e00\u5b9a\u8981\u5173\u6ce8\u9986\u957f\u54e6\uff0c\u53e6\u5916\u9986\u957f\u975e\u5e38\u64c5\u957f\u751f\u4fe1\u5206\u6790\uff0c\u53ef\u4ee5\u63d0\u4f9b\u4ed8\u8d39\u5206\u6790\u670d\u52a1\uff0c\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u54a8\u8be2\uff5e<\/span><span style=\"text-align: left;text-indent: 24pt;letter-spacing: 0.034em;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;\">   <\/span><\/p>\n<section>\n<section powered-by=\"xiumi.us\">\n<section>\n<section>\n<section powered-by=\"xiumi.us\">\n<section>\n<section powered-by=\"xiumi.us\">\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017368\" data-ratio=\"1\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-18.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'&from=appmsg\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017369\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_7TvAyUibd1TPhJmZfialJtv6tu2SEg-6.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100017370\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_9N02aBaau07RufXeXRLmvAHsrFZxtw-5.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;text-wrap: wrap;\"><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;margin-bottom: 0px;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"display: none;margin-bottom: 24px;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6027\u4ef7\u6bd4\u4e4b\u738b\uff013\u56fe0\u5b9e\u9a8c\u62ff\u4e0bSCI\u533b\u5b661\u533a\uff01\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u8054\u5408\u591a\u79cd\u9057\u4f20\u5b66\u65b9\u6cd5\u7814\u7a76\uff0c\u4ec5\u7528\u6570\u636e\u5206\u6790\u4e5f\u80fd\u8f7b\u677e\u4e0a8+\uff01 \u9986 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/52521"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=52521"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/52521\/revisions"}],"predecessor-version":[{"id":52533,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/52521\/revisions\/52533"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=52521"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=52521"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=52521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}