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onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAysHY49vPGCraibakiaNq6hQgn8C5MfvVLQGxlNZPEia2PajKAzrE2v0O5WiaUDJjgv5bxK2G1ePHyH2g\/640?wx_fmt=jpeg&wxfrom=5&wx_lazy=1&wx_co=1'\" data-w=\"1080\" \/><\/section>\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\"><span style=\"letter-spacing: 0.034em;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian Randomization, 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normal;text-transform: none;font-weight: bold;font-size: 16px;\">\uff08\u6ce8\uff1ax\u8f74\u4ee3\u8868SNP\u5bf9\u66b4\u9732\u7684\u5f71\u54cd\uff0cy\u8f74\u4ee3\u8868SNP\u5bf9\u7ed3\u5c40\u7684\u5f71\u54cd\u3002\u659c\u7387\u5c0f\u4e8e0\uff0c\u4ee3\u8868\u66b4\u9732\u56e0\u7d20\u662f\u7ed3\u5c40\u7684\u6709\u5229\u56e0\u7d20\uff09<\/span><\/section>\n<section style=\"text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u8fd9\u5f20\u56fe\u8868\u793a\u7684\u662f\u66b4\u9732\u56e0\u7d20\u4e0e\u7ed3\u5c40\u56e0\u7d20\u4e4b\u95f4\u7684MR\u5206\u6790\u7ed3\u679c\uff0c\u6bcf\u4e00\u4e2a\u70b9\u4ee3\u8868\u4e86\u4e00\u4e2a\u5de5\u5177\u53d8\u91cfSNP\u6bcf\u4e2a\u70b9\u4e0a\u7684\u7ebf\uff0c\u5b9e\u9645\u53cd\u5e94\u7684\u662f95%\u7684\u7f6e\u4fe1\u533a\u95f4\uff0c\u6a2a\u5750\u6807\u662fSNP\u5bf9\u66b4\u9732\u56e0\u7d20\uff08\u7761\u7720\u65f6\u95f4\uff09\u7684\u6548\u5e94\uff1b\u7eb5\u5750\u6807\u662fSNP\u5bf9\u7ed3\u5c40\u56e0\u7d20\uff08\u51a0\u5fc3\u75c5\uff09\u7684\u6548\u5e94\uff0c\u4e24\u4e2a\u6548\u5e94\u505a\u6bd4\u503c\uff0c\u5373\u66b4\u9732\u5bf9\u7ed3\u5c40\u7684\u6548\u5e94\uff0c\u4e5f\u5c31\u662f\u4e0a\u56fe\u4e2d\u5f69\u8272\u7ebf\u7684\u659c\u7387\uff0c\u4e0d\u540c\u989c\u8272\u7684\u7ebf\u8868\u793a\u7684\u662f\u4e0d\u540c\u7684\u7b97\u6cd5\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u4e0d\u540c\u7b97\u6cd5\u7684\u7ebf\u603b\u4f53\u662f\u659c\u5411\u4e0b\u7684\uff0c\u8fd9\u5c31\u610f\u5473\u7740\u968f\u7740\u7761\u7720\u65f6\u95f4\u7684\u5347\u9ad8\uff0c\u51a0\u5fc3\u75c5\u7684\u53d1\u75c5\u98ce\u9669\u5728\u964d\u4f4e\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100014907\" data-ratio=\"0.685546875\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-01-11_\u300c\u8f6c\u300d\u8d85\u8be6\u7ec6\uff01\u4e00\u6587\u5e26\u4f60\u8bfb\u61c2\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7ed3\u679c\/4_dcgiazvzRtb6zwQLGJaKzMdS12Nnuw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAwA8f7y7NSpZrnNlwLF9CD0TpxWUN8P6Kuzty8DKIxJaicYsodcgiazvzRtb6zwQLGJaKzMdS12Nnuw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"512\" height=\"351.010009765625\" width=\"512.010009765625\" \/><\/span><\/section>\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;\">\uff08\u6ce8\uff1a\u5224\u65ad\u6bcf\u4e2aSNP\u5bf9\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u7ed3\u679c\u7684\u5f71\u54cd\uff0c\u5982\u679c\u6709\u79bb\u7fa4\u503c\u9700\u8981\u53bb\u6389\u540e\u91cd\u65b0\u5206\u6790\uff09<\/span><\/section>\n<section style=\"text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">MR\u7ed3\u679c\u5206\u6790\u4e4b\u540e\u9700\u8981\u8fdb\u884c\u654f\u611f\u6027\u5206\u6790\u6765\u68c0\u9a8c\u5206\u6790\u7ed3\u679c\u7684\u53ef\u9760\u6027\u4e0e\u7a33\u5b9a\u6027\uff0c\u9010\u4e2a\u5254\u9664\u68c0\u9a8c\u5c31\u662f\u5176\u4e2d\u7684\u4e00\u4e2d\u3002\u9010\u4e2a\u5254\u9664\u68c0\u9a8c\uff0c\u6307\u7684\u662f\u9010\u6b65\u5254\u9664\u6bcf\u4e2aSNP\uff0c\u8ba1\u7b97\u5269\u4f59SNP\u7684meta\u6548\u5e94\uff0c\u89c2\u5bdf\u5254\u9664\u6bcf\u4e2aSNP\u540e\u7ed3\u679c\u662f\u5426\u53d1\u751f\u53d8\u5316\uff0c\u5982\u679c\u5254\u9664\u4e86\u67d0\u4e00\u4e2aSNP\u540e\uff0c\u7ed3\u679c\u6539\u53d8\u5f88\u5927\uff0c\u8bf4\u660e\u5b58\u5728\u67d0\u4e00\u4e2aSNP\u5bf9\u7ed3\u679c\u5f71\u54cd\u5f88\u5927\uff0c\u6709\u5f02\u5e38\u503c\u9700\u8981\u5254\u9664\u6389\uff0c\u5982\u4e0a\u56fe\u6240\u793a\uff0c\u5254\u9664\u6bcf\u4e2aSNP\u540e\uff0c\u603b\u4f53\u7684\u8bef\u5dee \u7ebf\u53d8\u5316\u4e0d\u5927\uff0c\u4e5f\u5c31\u662f\u6240\u6709\u7684\u8bef\u5dee\u7ebf\u5747\u57280\u7684\u53f3\u4fa7\uff0c\u6216\u8005\u6240\u6709\u7684\u8bef\u5dee\u7ebf\u90fd\u57280\u7684\u5de6\u4fa7\uff0c\u8bf4\u660e\u7ed3\u679c\u662f\u53ef\u9760\u7684\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-indent: 21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100014906\" data-ratio=\"0.8017057569296375\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-01-11_\u300c\u8f6c\u300d\u8d85\u8be6\u7ec6\uff01\u4e00\u6587\u5e26\u4f60\u8bfb\u61c2\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7ed3\u679c\/5_MBPVJfD9iaTT9hf6oNicFScxo2Yaww.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAwA8f7y7NSpZrnNlwLF9CD08lgn8Eiby78NZcM09e7lkLVbOlOMBPVJfD9iaTT9hf6oNicFScxo2Yaww\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"469\" height=\"376.010009765625\" width=\"469.010009765625\" \/><\/span><\/section>\n<section style=\"text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;\">\u6f0f\u6597\u56fe\u53ef\u4ee5\u770bSNP\u7684\u5f02\u8d28\u6027\uff0c\u4e0emeta\u5206\u6790\u4e2d\u7684\u6f0f\u6597\u56fe\u7c7b\u4f3c\uff0c\u4e3b\u8981\u5173\u6ce8IVW\u7ebf\u7684\u5de6\u53f3\u4e24\u8fb9\u7684\u70b9\u662f\u5426\u5927\u81f4\u5bf9\u79f0\uff0c\u5982\u679c\u6709\u7279\u522b\u79bb\u7fa4\u7684\u70b9\u8bf4\u660e\u6709\u79bb\u7fa4\u503c\uff0c\u53ef\u4ee5\u53bb\u9664\u540e\u518d\u6b21\u8fdb\u884cMR\u5206\u6790\u3002<\/span><\/section>\n<section style=\"text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u81f3\u6b64\u4eca\u5929\u7684\u5206\u4eab\u5230\u8fd9\u91cc\u5c31\u7ed3\u675f\u4e86\uff0c\u540e\u9762\u5c0f\u679c\u4f1a\u7ee7\u7eed\u4e3a\u5927\u5bb6\u5206\u4eab\u6bcf\u4e2a\u6b65\u9aa4\u7684\u5177\u4f53\u64cd\u4f5c\u548c\u4e00\u4e9b\u6ce8\u610f\u4e8b\u9879\uff0c\u6b22\u8fce\u5927\u5bb6\u7ee7\u7eed\u5173\u6ce8\u54e6\u3002<\/span><span style=\"font-family: \u5b8b\u4f53;text-indent: 21pt;letter-spacing: 0.034em;\">         <\/span><\/span><o:p style=\"font-family: \u5b8b\u4f53;text-indent: 21pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\"><span style=\"font-size: 16px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u60f3\u8981\u66f4\u597d\u7684\u5b66\u4e60\u548c\u4ea4\u6d41\uff0c\u5feb\u6765\u52a0\u5165\u5c0f\u679c\u7684\u5fae\u4fe1\u516c\u4f17\u53f7\uff08\u751f\u4fe1\u56fe\uff09\u548c\u4e91\u751f\u4fe1\u751f\u7269\u4fe1\u606f\u5b66\u5e73\u53f0\uff08  http:\/\/www.biocloudservice.com\/home.html\uff09\uff0c\u5728\u8fd9\u91cc\u4f60\u53ef\u4ee5\u5411\u5c0f\u679c\u63d0\u95ee\u3001\u5e2e\u4f60\u5236\u5b9a\u76f8\u5e94\u5206\u6790\u64cd\u4f5c\u3002\u70b9\u51fb\u8fd9\u91cc\u52a0\u5165\u5427\uff01<\/span>   <\/span><\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;\">\n<section>\n<section powered-by=\"xiumi.us\">\n<section>\n<section powered-by=\"xiumi.us\">\n<section>\n<section powered-by=\"xiumi.us\">\n<section>\n<section>\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100014911\" data-ratio=\"0.5555555555555556\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-01-11_\u300c\u8f6c\u300d\u8d85\u8be6\u7ec6\uff01\u4e00\u6587\u5e26\u4f60\u8bfb\u61c2\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7ed3\u679c\/6_VmRkv7tSNKliafDnsuFR7BoeDgBrww.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxPqeNQsFjm2HibIuSld9Nh9GicQSWhJwHjia5tEevQvDIebLErVmRkv7tSNKliafDnsuFR7BoeDgBrww\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"900\" style=\"font-size: var(--articleFontsize);letter-spacing: 0.034em;\" \/><br \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-left: 0pt;letter-spacing: 0.578px;text-indent: 0pt;text-wrap: wrap;text-align: justify;font-size: 12pt;font-family: helvetica;color: rgb(0, 0, 0);break-after: auto;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100014912\" data-ratio=\"0.38981481481481484\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-01-11_\u300c\u8f6c\u300d\u8d85\u8be6\u7ec6\uff01\u4e00\u6587\u5e26\u4f60\u8bfb\u61c2\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7ed3\u679c\/7_FbEg9fibwQicL8l2ExKOZZTmAHXabQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAx3HetBkB7aOGibFWKqibqIATyC4zFibzCgdrxFwRep6cDMLIbA0FbEg9fibwQicL8l2ExKOZZTmAHXabQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"font-size: var(--articleFontsize);letter-spacing: 0.034em;caret-color: rgba(0, 0, 0, 0);\" \/><\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;letter-spacing: 0.578px;text-wrap: wrap;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);text-align: left;\">\n<section style=\"outline: 0px;font-size: 16px;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section powered-by=\"xiumi.us\" style=\"margin: 10px;outline: 0px;justify-content: flex-start;display: flex;flex-flow: row;\">\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;display: inline-block;width: 558px;vertical-align: top;border-style: dashed;border-width: 1px;border-color: rgb(62, 62, 62);align-self: flex-start;flex: 0 0 auto;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;\">\n<section style=\"outline: 0px;display: inline-block;width: 536px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(144, 215, 236);border-right-color: rgb(46, 172, 109);box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-bottom-left-radius: 0px;\">\n<section powered-by=\"xiumi.us\" style=\"padding-right: 3px;padding-left: 3px;outline: 0px;\">\n<section style=\"margin-top: 0.95em;margin-bottom: -0.65em;outline: 0px;display: inline-block;width: 520px;vertical-align: top;\">\n<section style=\"margin-top: -1em;padding: 3px 10px;outline: 0px;display: inline-block;vertical-align: top;color: rgb(0, 154, 68);\">\n<p style=\"outline: 0px;\"><span style=\"font-size: 16px;\"><strong style=\"outline: 0px;\">\u5f80\u671f\u63a8\u8350<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;text-align: justify;\">\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491794&idx=1&sn=2b7a4de95169c79202e44813885a8250&chksm=cf7f7017f808f9015689839fe4057fd418bf7b20eb1dfb5a28cd92e56a41b5605e62bfbc16fb&scene=21#wechat_redirect\" textvalue=\"1.\u642d\u5efa\u751f\u4fe1\u5206\u6790\u6d41\u6c34\u7ebf\uff0c\u5982\u5de5\u5382\u4e00\u683724\u5c0f\u65f6\u8fd0\u8f6cSnakemake\u2014\u2014\u8fdb\u9636\u547d\u4ee4\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" 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16px;\">5.\u8f6f\u4ef6\u5305\u5b89\u88c5\u3001\u6253\u602a\u5feb\u53c8\u597d\uff0c1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff1b\u8fd8\u6709\u6bd4\u8fd9\u66f4\u7701\u94b1\u7684\u561b\uff01\uff01\uff01<\/span><\/a><span style=\"text-indent: 0em;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;font-size: 16px;\"> <\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><o:page><\/o:page><\/section>\n<p style=\"display: none;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8d85\u8be6\u7ec6\uff01\u4e00\u6587\u5e26\u4f60\u8bfb\u61c2\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7ed3\u679c 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