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style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#0070C0;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\">\uff08ps\uff1a\u60f3\u8981\u4e86\u89e3\u6700\u65b0\u7684\u751f\u4fe1\u601d\u8def\uff0c\u6765\u627e\u9986\u957f\u5c31\u5bf9\u4e86\uff0c\u8fd9\u91cc\u6709\u4e0d\u4ec5\u6709\u70ed\u70b9\u65b9\u5411\u8fd8\u6709\u521b\u65b0\u601d\u8def\uff0c\u60f3\u601d\u8def\u590d\u73b0\u53ef\u4ee5\u76f4\u63a5\u626b\u7801call\u9986\u957f\uff0c\u7b49\u4f60\u54e6\uff01\uff09<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#0070C0;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\"><br \/><\/span><\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100006476\" data-ratio=\"1\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 142px;height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_f6PG40Qrdu5e9B1iaIMItPiajABYWA-38.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxqaqPbQprPd4vw8Ytp0cprbzXiakMDdFriaB6B59ibhlBCrNyQFf6PG40Qrdu5e9B1iaIMItPiajABYWA\/640?wx_fmt=jpeg'\" data-recalc-dims=\"1\" \/><\/p>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009430\" data-ratio=\"0.46574074074074073\" data-type=\"png\" data-w=\"1080\" height=\"257 .6700134277344\" width=\"553 .739990234375\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_Acibd50uAm8NtsTJmtegxFc6w47lUA-6.png?resize=553%2C257\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx4nVlLy2VdzmE8QLEhKq0qQWia7os1RZuE8OcqD11sFyntkZqAcibd50uAm8NtsTJmtegxFc6w47lUA\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u25cf \u9898\u76ee\uff1a\u5229\u7528\u4eba\u5de5\u667a\u80fd\u884d\u751f\u9884\u540e\u6307\u6570\u786e\u5b9a<\/span><span style=\"mso-bookmark:_Hlk159934340;\"><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u89d2\u9ca8\u70ef\u73af\u6c27\u5316\u7269\u9176<\/span><\/span><span style=\"mso-bookmark:_Hlk159934340;\"><\/span><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u662f\u9ad8\u5371\u9aa8\u8089\u7624\u4e2d\u7684\u4ee3\u8c22\u6f0f\u6d1e<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u25cf \u6742\u5fd7\uff1a<\/span><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-style:italic;mso-bidi-font-style:italic;\">Clinical and Translational Medicine<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u25cf \u5f71\u54cd\u56e0\u5b50\uff1aIF=10.6<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u25cf \u53d1\u8868\u65f6\u95f4\uff1a2024\u5e742\u6708<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><br \/><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"mso-bidi-font-size:10.5pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u7814\u7a76\u80cc\u666f<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u9aa8\u8089\u7624\uff08OSA\uff09\u662f\u4e00\u9879\u4e34\u5e8a\u6311\u6218\uff0c\u51765\u5e74\u751f\u5b58\u7387\u5f88\u4f4e\u3002\u76ee\u524d\uff0c\u7531\u4e8e\u7f3a\u4e4f\u5148\u8fdb\u7684\u5206\u5c42\u6a21\u578b\uff0c\u5f88\u96be\u8fdb\u884c\u4e2a\u6027\u5316\u6cbb\u7597\u3002\u672c\u7814\u7a76\u65e8\u5728\u786e\u5b9a\u65b0\u578b\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5bf9\u9ad8\u5371\u9aa8\u8089\u7624\u60a3\u8005\u8fdb\u884c\u5206\u5c42\u5e76\u6307\u5bfc\u6cbb\u7597\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u6570\u636e\u6765\u6e90<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\"><br \/><\/span><\/section>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"567\" style=\"border-width: initial;border-style: none;border-color: initial;border-collapse: collapse;width: 100%;\">\n<tbody>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#8EABDC;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">\u6570\u636e\u96c6\/\u961f\u5217<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#8EABDC;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">\u6570\u636e\u5e93<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#8EABDC;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">\u6570\u636e\u7c7b\u578b<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#8EABDC;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">\u8be6\u7ec6\u4fe1\u606f<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">TARGET-OSA<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">GDC<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">\u591a\u7ec4\u5b66\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">Bulk RNA-seq\u6570\u636e\u3001\u57fa\u56e0\u6c34\u5e73\u62f7\u8d1d\u6570\u53d8\u5f02\u3001\u5c4f\u853d\u4f53\u7ec6\u80de\u7a81\u53d8\u56fe\u8c31\u3001\u5c4f\u853dDNA\u7532\u57fa\u7ec4\u5f3a\u5ea6\uff0c\u4ee5\u53ca\u6765\u81ea “\u4ea7\u751f\u6709\u6548\u6cbb\u7597\u7684\u6cbb\u7597\u5b66\u5e94\u7528\u7814\u7a76\uff08TARGET\uff09”\u8ba1\u5212\u7684\u76f8\u5173\u4e34\u5e8a\u6570\u636e\uff08n=85\uff09<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE21257<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">\u5fae\u9635\u5217\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">5 \u5e74\u5185\u53d1\u751f\u8f6c\u79fb\u7684\u9aa8\u8089\u7624\u60a3\u8005\u7684\u5316\u7597\u524d\u6d3b\u68c0 \uff08n=34\uff09 \u4e0e 5 \u5e74\u5185\u672a\u53d1\u751f\u8f6c\u79fb\u7684\u9aa8\u8089\u7624\u60a3\u8005\u7684\u5316\u7597\u524d\u6d3b\u68c0\u6837\u672c\uff08n=19\uff09<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE33382<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">\u5fae\u9635\u5217\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">84 \u4f8b\u6cbb\u7597\u524d\u9ad8\u7ea7\u522b\u9aa8\u8089\u7624\u8bca\u65ad\u6d3b\u68c0\u6837\u672c<\/span>        <o:page><\/o:page><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE16091<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">\u5fae\u9635\u5217\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">34\u4f8b\u4eba\u7c7b\u8089\u9aa8\u7624\u6837\u672c<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE14827<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">\u5fae\u9635\u5217\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">27 \u4e2a\u9aa8\u8089\u7624\u624b\u672f\u6837\u672c<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE87437<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">\u5fae\u9635\u5217\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\" lang=\"EN-US\"><span style=\"mso-tab-count:1 Blank;\">   <\/span>\u4f4d\u4e8e\u56db\u80a2\u7684 21 \u4f8b\u9ad8\u7ea7\u522b\u9aa8\u8089\u7624<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE42352<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">\u5fae\u9635\u5217\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">3 \u4e2a\u6210\u9aa8\u7ec6\u80de\u300112 \u4e2a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u548c 19 \u4e2a OSA \u7ec6\u80de\u7cfb<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE16089<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">\u5fae\u9635\u5217\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">\u8010 MTX \u7684 Saos2 \u53ca\u5176\u6bcd\u672c\u7ec6\u80de\u7cfb\uff0c\u5206\u522b\u6709 3 \u4e2a\u91cd\u590d\u5e8f\u5217<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE9967<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">\u5fae\u9635\u5217\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">18 \u540d\u60a3\u8005\u7684 OSA \u6837\u672c\u548c\u914d\u5bf9\u6b63\u5e38\u9aa8\u7ec4\u7ec7<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">GSE238110<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">RNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">186 \u4f8b\u72ac\u9aa8\u8089\u7624\u539f\u53d1\u6027\u80bf\u7624\u6837\u672c<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">PRJNA681896<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">GDC<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">scRNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#ECF1F9;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">6\u4e2aOSA\u6d3b\u68c0\u6837\u672c<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"127\" valign=\"middle\" style=\"width:95.5pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;font-weight:normal;\">PRJNA698672<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:normal;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"width:52.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">GDC<\/span><\/section>\n<\/td>\n<td width=\"130\" valign=\"middle\" style=\"width:97.55pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">RNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"239\" valign=\"middle\" style=\"width:179.4pt;background:#FFFFFF;border-top:solid #4472C4 1.0pt;mso-border-top-alt:solid #4472C4 0.5pt;border-left:solid #4472C4 1.0pt;mso-border-left-alt:solid #4472C4 0.5pt;border-bottom:solid #4472C4 1.0pt;mso-border-bottom-alt:solid #4472C4 0.5pt;border-right:solid #4472C4 1.0pt;mso-border-right-alt:solid #4472C4 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#000000;mso-bidi-font-weight:bold;\">OSA\u7ec4\u7ec7\u548c\u6765\u81ea\u56db\u540d\u60a3\u8005\u7684\u914d\u5bf9\u76f8\u90bb\u6b63\u5e38\u7ec4\u7ec7<\/span><\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><br \/><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u7814\u7a76\u601d\u8def<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u5c06 10 \u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u7ec4\u5408\u6210 101 \u79cd\u7ec4\u5408\uff0c\u5e76\u6839\u636e 254 \u4e2a\u6837\u672c\u7684\u8f6c\u5f55\u7ec4\u56fe\u8c31\u5efa\u7acb\u4e86\u9884\u6d4b\u603b\u751f\u5b58\u671f\u7684\u6700\u4f73\u6a21\u578b\u3002\u8bc4\u4f30\u4e86\u8f6c\u5f55\u7ec4\u3001\u57fa\u56e0\u7ec4\u548c\u8868\u89c2\u57fa\u56e0\u7ec4\u56fe\u8c31\u7684\u53d8\u5316\uff0c\u4ee5\u9610\u660e\u4e0d\u826f\u9884\u540e\u7684\u9a71\u52a8\u673a\u5236\u3002\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u63ed\u793a\u4e86OSA\u7ec6\u80de\u4e2d\u4f5c\u4e3a\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u8fc7\u5ea6\u8868\u8fbe\u7684\u57fa\u56e0\uff0c\u5176\u4e2d\u4e00\u4e2a\u57fa\u56e0\u901a\u8fc7\u7ec4\u7ec7\u67d3\u8272\u3001\u57fa\u56e0\u6572\u9664\u548c\u836f\u7406\u6291\u5236\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002\u63cf\u8ff0\u4e86\u591a\u79cd\u8868\u578b\u7684\u53d8\u5316\uff0c\u5305\u62ec\u589e\u6b96\u3001\u96c6\u843d\u5f62\u6210\u3001\u8fc1\u79fb\u3001\u4fb5\u88ad\u3001\u51cb\u4ea1\u3001\u5316\u5b66\u654f\u611f\u6027\u548c\u4f53\u5185\u81f4\u7624\u6027\u3002RNA-seq\u548cWestern\u5370\u8ff9\u9610\u660e\u4e86\u89d2\u9ca8\u70ef\u73af\u6c27\u5316\u7269\u9176\uff08SQLE\uff09\u6291\u5236\u5bf9\u4fe1\u53f7\u901a\u8def\u7684\u5f71\u54cd\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u4e3b\u8981\u7ed3\u679c<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(255, 251, 0);\">1. \u4eba\u5de5\u667a\u80fd\u884d\u751f\u9884\u540e\u6307\u6570\uff08AIDPI\uff09\u7684\u5f00\u53d1\u4e0e\u9a8c\u8bc1<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u5c06 GSE21257\u548c GSE16091 \u4e24\u4e2a\u961f\u5217\u5408\u5e76\u4e3a GEO-OSA \u961f\u5217\uff0c\u5c06\u8be5\u961f\u5217\u4f5c\u4e3a\u8bad\u7ec3\u96c6\u3002\u540c\u65f6\uff0cTARGET-OSA \u4f5c\u4e3a\u9a8c\u8bc1\u96c6\u3002\u53d1\u73b0\u8bad\u7ec3\u96c6\u548c\u9a8c\u8bc1\u96c6\u5171\u6709 18 \u4e2a \u9884\u540e\u57fa\u56e0 \uff08CPG\uff09\u3002\u5c06\u8fd9\u4e9b CPG \u8f93\u5165\u673a\u5668\u5b66\u4e60\u6846\u67b6\uff0c\u5728\u8bad\u7ec3\u96c6\u4e2d\u751f\u6210\u591a\u4e2a\u9884\u540e\u6a21\u578b\u3002\u5728\u5bf9\u8bad\u7ec3\u96c6\u3001\u9a8c\u8bc1\u96c6\u548c\u72ec\u7acb\u6d4b\u8bd5\u96c6\uff08GSE33382\uff09\u8fdb\u884c\u8bc4\u4f30\u540e\uff0cCoxBoost \u548c\u5ea6\u63d0\u5347\u673a \uff08GBM\uff09\u7ec4\u5408\u5efa\u7acb\u7684\u6a21\u578b\u88ab\u9009\u4e3a\u6700\u4f73\u6a21\u578b\uff0c\u56e0\u4e3a\u5b83\u7684\u5e73\u5747 C \u6307\u6570\u662f\u6700\u9ad8\u7684\uff08\u56fe 1A\uff09\u3002\u8be5\u6a21\u578b\u7531 12 \u4e2a\u57fa\u56e0\u7ec4\u6210\u3002\u5229\u7528\u8be5\u6a21\u578b\uff0c\u8ba1\u7b97\u4e86\u591a\u4e2a\u961f\u5217\u4e2d\u6bcf\u4f4d\u60a3\u8005\u7684 AIDPI\u3002tROC\u5206\u6790\u663e\u793a\uff0c\u8bad\u7ec3\u96c6\u3001\u9a8c\u8bc1\u96c6\u548c\u72ec\u7acb\u6d4b\u8bd5\u96c6\u4e2d1\u5e74\u30013\u5e74\u548c5\u5e74OS\u7684ROC-AUC\u89c1\u56fe1B-D\u3002\u6839\u636e\u8bad\u7ec3\u96c6\u786e\u5b9a\u7684 AIDPI \u6700\u4f73\u9608\u503c\uff0cOSA \u60a3\u8005\u88ab\u5206\u4e3a\u4f4e AIDPI \u7ec4\u548c\u9ad8 AIDPI \u7ec4\u3002\u5728\u8bad\u7ec3\u96c6\u3001\u9a8c\u8bc1\u96c6\u548c\u72ec\u7acb\u6d4b\u8bd5\u96c6\uff08\u56fe 1E-G\uff09\u4e2d\uff0cKMSA \u53d1\u73b0\u9ad8 AIDPI \u7ec4\u7684\u7ed3\u679c\u660e\u663e\u4e0d\u5229\u3002\u8fd9\u4e00\u8d8b\u52bf\u5728\u5176\u4ed6\u961f\u5217\uff08\u56fe 1H-M\uff09\u4e2d\u4e5f\u5f97\u5230\u4e86\u4e00\u81f4\u7684\u89c2\u5bdf\uff0c\u5305\u62ec\u5408\u5e76\u7684meta OSA \u961f\u5217\uff08\u56fe 1J,M\uff09\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u5728\u4e0a\u8ff0\u516d\u4e2a\u961f\u5217\u4e2d\u8fdb\u4e00\u6b65\u8bc4\u4f30\u4e86 AIDPI \u548c 68 \u4e2a\u4ee5\u524d\u53d1\u8868\u7684 OSA \u7279\u5f81\u7684\u9884\u6d4b\u80fd\u529b\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5fae\u9635\u5217\u6570\u636e\u96c6\u4e2d\u57fa\u56e0\u547d\u540d\u7684\u6539\u53d8\u548c\u57fa\u56e0\u7f3a\u5931\uff0c\u53ea\u6709 53 \u4e2a\u5df2\u53d1\u8868\u7684\u7279\u5f81\u548c AIDPI \u5728\u81f3\u5c11\u4e00\u4e2a\u961f\u5217\u4e2d\u8fdb\u884c\u4e86\u6d4b\u8bd5\uff0c\u7ed3\u679c\u4ee5\u70ed\u56fe\u7684\u5f62\u5f0f\u663e\u793a\u51fa\u6765\uff08\u56fe 1N\uff09\u3002\u8be5\u70ed\u56fe\u663e\u793a\uff0c\u5728\u6240\u6709\u961f\u5217\u4e2d\u53ea\u6709\u4e24\u4e2a\u7279\u5f81\u4e00\u81f4\u5730\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u610f\u4e49\uff1aAIDPI \u548c \u4e4b\u524dXu \u7b49\u4eba\u7684\u7279\u5f81\u3002\u76f4\u63a5\u7684 C \u6307\u6570\u6bd4\u8f83\u5f3a\u8c03\u4e86 AIDPI \u5728\u4e09\u4e2a\u961f\u5217\u4e2d\u660e\u663e\u4f18\u4e8e Xu \u7b49\u4eba\u7684\u7279\u5f81\uff08\u56fe 1O\uff09\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cAIDPI \u53ef\u4ee5\u9884\u6d4b OSA \u60a3\u8005\u7684\u9884\u540e\uff0c\u5e76\u4e14\u4f18\u4e8e\u4e4b\u524d\u5efa\u7acb\u7684\u7279\u5f81\u3002<\/span><span style=\"font-size: 10.5pt;text-indent: 0pt;letter-spacing: 0.034em;\"> <\/span><span style=\"font-size: 10.5pt;text-indent: 0pt;letter-spacing: 0.034em;\"> <\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;line-height: 1.75em;\"><o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009431\" data-ratio=\"1.3138888888888889\" data-type=\"jpeg\" data-w=\"1080\" height=\"649 .0800170898438\" width=\"549 .47998046875\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_XJS4JqChGjCk6TtXwkW5j5ceZz4r1A-6.jpg?resize=549%2C649\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx4nVlLy2VdzmE8QLEhKq0qQOyPibmlhHPic0jibvia54DqHoNocXJS4JqChGjCk6TtXwkW5j5ceZz4r1A\/640?wx_fmt=jpeg'\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe1 AIDPI\u7684\u5f00\u53d1\u4e0e\u9a8c\u8bc1<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(255, 251, 0);\">2. \u57fa\u4e8e AIDPI \u548c\u4e34\u5e8a\u7279\u5f81\u7684\u751f\u5b58\u9884\u6d4b\u589e\u5f3a\u529f\u80fd<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u9274\u4e8e\u591a\u4e2a\u4e34\u5e8a\u53d8\u91cf\u5bf9 OSA \u60a3\u8005\u9884\u540e\u7684\u5f71\u54cd\u5df2\u5f97\u5230\u516c\u8ba4\uff0c\u63a5\u7740\u8bd5\u56fe\u9610\u660e\u8fd9\u4e9b\u56e0\u7d20\u4e0e AIDPI \u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u4ee5\u786e\u8ba4 AIDPI \u662f\u72ec\u7acb\u7684\u9884\u540e\u751f\u7269\u6807\u8bb0\u7269\uff0c\u5e76\u5efa\u7acb\u4e00\u4e2a\u7efc\u5408\u6a21\u578b\u6765\u589e\u5f3a\u751f\u5b58\u9884\u6d4b\u3002Meta OSA\u4e2d\u7684\u5355\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\u663e\u793a\uff0c\u60a3\u8005\u7684OS\u4e0eAIDPI\u3001\u5e74\u9f84\u3001MSTS\u5206\u671f\u3001Huvos\u5206\u7ea7\u548c\u539f\u53d1\u80bf\u7624\u90e8\u4f4d\u7b49\u53c2\u6570\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u5173\u8054\uff08\u56fe2A\uff09\u3002\u5728TARGET-OSA\u961f\u5217\u4e2d\uff0c\u670943\u540d\u60a3\u8005\u7684Huvos\u5206\u7ea7\u53ef\u7528\uff0c\u4e14\u9ad8AIDPI\u8bc4\u5206\u5bf9\u5e94\u4e8eHuvos\u5206\u7ea7I\/II\uff08\u56fe2B\uff09\u3002\u5f53\u8bc4\u4f30\u5176\u5bf9\u5316\u7597\u53cd\u5e94\u7684\u9884\u6d4b\u80fd\u529b\u65f6\uff0cAIDPI \u7684 AUC \u4e3a 0.713\uff08\u56fe 2C\uff09\u3002\u8fd9\u4e00\u9884\u6d4b\u7279\u6027\u5728\u6269\u5927\u7684 OSA-Huvos \u6570\u636e\u96c6\u4e2d\u518d\u6b21\u5f97\u5230\u4e86\u8bc1\u5b9e\uff0c\u8be5\u6570\u636e\u96c6\u7531\u4e94\u4e2a\u6570\u636e\u96c6\u4e2d\u542b\u6709 Huvos \u5206\u7ea7\u4fe1\u606f\u7684\u6837\u672c\u7ec4\u6210\uff0c\u5176\u4e2d Huvos \u5206\u7ea7 I\/II \u518d\u6b21\u4e0e AIDPI \u5f97\u5206\u5347\u9ad8\u76f8\u5bf9\u5e94\uff08\u56fe 2D\uff09\uff0cAIDPI \u5728\u9884\u6d4b\u65b0\u8f85\u52a9\u5316\u7597\u53cd\u5e94\u65b9\u9762\u7684 AUC \u4e3a 0.756\uff08\u56fe 2E\uff09\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u5bf9meta-OSA\u961f\u5217\u8fdb\u884c\u7684\u591a\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\u53d1\u73b0\uff0cAIDPI\u3001MSTS\u5206\u671f\u3001Huvos\u5206\u7ea7\u548c\u539f\u53d1\u80bf\u7624\u90e8\u4f4d\u662f\u72ec\u7acb\u7684\u9884\u540e\u56e0\u7d20\uff08\u56fe2F\uff09\u3002\u9274\u4e8eHuvos\u5206\u7ea7\u7684\u7f3a\u5931\u503c\u8d85\u8fc725%\uff0c\u800cAIDPI\u5728\u9884\u6d4b\u65b0\u8f85\u52a9\u5316\u7597\u53cd\u5e94\u65b9\u9762\u5177\u6709\u5f88\u9ad8\u7684\u51c6\u786e\u6027\uff0c\u56e0\u6b64Huvos\u5206\u7ea7\u88ab\u6392\u9664\u5728\u591a\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\u4e4b\u5916\uff08\u56fe2G\uff09\u3002\u6839\u636e\u4fee\u8ba2\u540e\u7684\u6a21\u578b\uff0c\u6784\u5efa\u4e86\u9884\u6d4b\u60a3\u8005\u751f\u5b58\u6982\u7387\u7684\u5217\u7ebf\u56fe\uff08\u56fe 2H\uff09\u3002\u6821\u51c6\u66f2\u7ebf\uff08\u56fe 2I\uff09\u548c tROC \u8bc4\u4f30\uff08\u56fe 2J\uff09\u8bc1\u5b9e\u4e86\u8be5\u5217\u7ebf\u56fe\u7684\u5f3a\u5927\u9884\u6d4b\u80fd\u529b\u3002\u6b64\u5916\uff0c\u6839\u636e AUC \u5206\u6790\uff0c\u8be5\u5217\u7ebf\u56fe\u7684\u6027\u80fd\u8d85\u8fc7\u4e86\u5176\u4ed6\u56e0\u7d20\uff08\u56fe 2K\uff09\uff0cDCA \u663e\u793a\u5176\u51c0\u83b7\u76ca\u6bd4\u5176\u4ed6\u4e34\u5e8a\u53c2\u6570\u66f4\u5e7f\u6cdb\uff08\u56fe 2L\uff09\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u8fd9\u4e9b\u53d1\u73b0\u7a81\u51fa\u8868\u660e AIDPI \u662f\u4e00\u4e2a\u72ec\u7acb\u7684\u9884\u540e\u6307\u6807\u3002\u6b64\u5916\uff0c\u57fa\u4e8eAIDPI\u3001\u5e74\u9f84\u3001MSTS\u5206\u671f\u548c\u539f\u53d1\u80bf\u7624\u90e8\u4f4d\u7684\u5217\u7ebf\u56fe\u5df2\u6210\u4e3a\u9884\u6d4bOSA\u60a3\u8005\u9884\u540e\u7684\u5de5\u5177\uff0c\u5176\u6548\u679c\u4f18\u4e8e\u5b64\u7acb\u7684\u4e34\u5e8a\u75c5\u7406\u7279\u5f81\u3002<\/span><span style=\"font-size: 10.5pt;text-indent: 0pt;letter-spacing: 0.034em;\">   <\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009434\" data-ratio=\"1.3138888888888889\" data-type=\"jpeg\" data-w=\"1080\" height=\"631 .010009765625\" width=\"548 .47998046875\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_7fhYjHrQodXbrawVOxE2AVE0G9FxOw-6.jpg?resize=548%2C631\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx4nVlLy2VdzmE8QLEhKq0qQiaFEFJxSC8yT8cI5vVicVzG3su7fhYjHrQodXbrawVOxE2AVE0G9FxOw\/640?wx_fmt=jpeg'\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe2 \u57fa\u4e8eAIDPI\u548c\u4e34\u5e8a\u7279\u5f81\u7684\u751f\u5b58\u9884\u6d4b<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(255, 251, 0);\">3. \u8bc6\u522b\u9ad8 AIDPI \u60a3\u8005\u4e2d\u5931\u8c03\u7684\u901a\u8def<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u4ece TARGET-OSA \u6570\u636e\u96c6\u5f97\u51fa\u7684\u70ed\u56fe\u663e\u793a\u4e86 AIDPI\u3001\u514d\u75ab\u8bc4\u5206\u548c\u7528\u4e8e\u8ba1\u7b97 AIDPI \u7684 12 \u4e2a\u57fa\u56e0\uff08AIDPI \u57fa\u56e0\uff09\u7684\u8868\u8fbe\u6a21\u5f0f\u3002\u5728\u9ad8 AIDPI \u7ec4\u4e2d\uff0c7 \u4e2a AIDPI \u57fa\u56e0\u8868\u73b0\u51fa\u660e\u663e\u7684\u4e0a\u8c03\uff0c\u5176\u4e2d 5 \u4e2a\u4e0e\u514d\u75ab\u8bc4\u5206\u6210\u53cd\u6bd4\u3002\u53e6\u4e00\u65b9\u9762\uff0c5 \u4e2a AIDPI \u57fa\u56e0\u8868\u73b0\u51fa\u660e\u663e\u7684\u4e0b\u8c03\uff0c\u5176\u4e2d 3 \u4e2a\u4e0e\u514d\u75ab\u8bc4\u5206\u5448\u6b63\u76f8\u5173\uff08\u56fe 3A\uff09\u3002GSEA \u786e\u5b9a\u4e86\u9ad8 AIDPI \u7ec4\u4e2d\u589e\u5f3a\u7684\u57fa\u56e0\u96c6\uff0c\u5305\u62ec MYC \u9776\u70b9 V2\u3001MYC \u9776\u70b9 V1\u3001\u80c6\u56fa\u9187\u7a33\u6001\u548c mTORC1 \u4fe1\u53f7\u4f20\u5bfc\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u6709\u5173\u7ec6\u80de\u51cb\u4ea1\u548c\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u7684\u57fa\u56e0\u96c6\u5219\u5448\u8d1f\u5bcc\u96c6\uff08\u56fe 3B\uff09\u3002\u5bf9 DEGs \u7684 KEGG \u5bcc\u96c6\u5206\u6790\u7a81\u663e\u4e86\u5bf9 OSA \u8fdb\u5c55\u81f3\u5173\u91cd\u8981\u7684\u901a\u8def\uff08\u56fe 3C\uff09\uff0c\u5305\u62ec PI3K-Akt \u4fe1\u53f7\u4f20\u5bfc\u3001\u7ec6\u80de\u56e0\u5b50-\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u3001\u7834\u9aa8\u7ec6\u80de\u5206\u5316\u3001\u75c5\u7076\u7c98\u9644\u548c\u7ec6\u80de\u5916\u57fa\u8d28\uff08ECM\uff09-\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u8fdb\u4e00\u6b65\u63a2\u7d22\u7684\u76ee\u7684\u662f\u901a\u8fc7\u6df1\u5165\u7814\u7a76\u57fa\u56e0\u7ec4\u548c\u8868\u89c2\u57fa\u56e0\u7ec4\u6570\u636e\uff0c\u627e\u51fa\u8f6c\u5f55\u7ec4\u5931\u8c03\u7684\u6839\u6e90\u3002AIDPI \u57fa\u56e0\u7f3a\u4e4f\u4f53\u7ec6\u80de\u7a81\u53d8\u3002\u867d\u7136\u7532\u57fa\u7ec4\u5206\u6790\u5e76\u672a\u53d1\u73b0\u4e24\u7ec4 AIDPI \u4e4b\u95f4\u5e73\u5747\u7532\u57fa\u5316\u6c34\u5e73\u7684\u663e\u8457\u53d8\u5316\uff08\u56fe 3E\uff09\uff0c\u4f46\u57fa\u4e8e\u8868\u89c2\u57fa\u56e0\u7ec4\u6570\u636e50 \u901a\u8fc7\u7ecf\u9a8c\u8d1d\u53f6\u65af GSEA \u5bcc\u96c6\u7684 KEGG \u901a\u8def\u663e\u793a\uff0c\u75c5\u7076\u7c98\u9644\u65b9\u9762\u7684\u5931\u8c03\u6700\u4e3a\u663e\u8457\uff08\u56fe 3F\uff09\uff0c\u8fd9\u4e0e\u8f6c\u5f55\u7ec4\u7684\u7814\u7a76\u7ed3\u679c\uff08\u56fe 3C\uff09\u5982\u51fa\u4e00\u8f99\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u8f6c\u5f55\u7ec4\u6c34\u5e73\u7684\u5f02\u5e38\u901a\u8def\u53ef\u80fd\u6e90\u4e8e\u9ad8 AIDPI \u7fa4\u7ec4\u4e2d DNA \u62f7\u8d1d\u6570\u53d8\u5f02\u548c DNA \u7532\u57fa\u5316\u6539\u53d8\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u6b64\u5916\uff0c\u8f6c\u5f55\u7ec4\u5206\u6790\u8fd8\u7a81\u51fa\u663e\u793a\u4e86\u9020\u8840\u7ec6\u80de\u7cfb\u7684\u5bcc\u96c6\uff08\u56fe 3C\uff09\uff0c\u6697\u793a\u4e86\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u7684\u6539\u53d8\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u9ad8AIDPI\u7ec4\u7684\u4e0d\u826f\u9884\u540e\u53ef\u80fd\u6e90\u4e8eOSA\u4e2dDNA\u62f7\u8d1d\u6570\u3001DNA\u7532\u57fa\u5316\u548c\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u6a21\u5f0f\u6539\u53d8\u6240\u5f15\u53d1\u7684\u901a\u8def\u6539\u53d8\u3002<\/span><span style=\"font-size: 10.5pt;text-indent: 0pt;letter-spacing: 0.034em;\"> <\/span><span style=\"font-size: 10.5pt;text-indent: 0pt;letter-spacing: 0.034em;\">  <\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009433\" data-ratio=\"1.3138888888888889\" data-type=\"jpeg\" data-w=\"1080\" height=\"639 .1400146484375\" width=\"549 .010009765625\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_RsqNZXZtvKQKGEyIvMtP5bvsO13hRg-6.jpg?resize=549%2C639\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx4nVlLy2VdzmE8QLEhKq0qQzB8SHj1SapTpj5TABZQBauBNRsqNZXZtvKQKGEyIvMtP5bvsO13hRg\/640?wx_fmt=jpeg'\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe3 \u8bc6\u522b\u9ad8AIDPI\u60a3\u8005\u7684\u5931\u8c03\u901a\u8def<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(255, 251, 0);\">4. \u786e\u5b9a\u9ad8 AIDPI \u60a3\u8005\u7684\u6cbb\u7597\u9776\u70b9<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u4e3a\u4e86bulk RNA-seq\u6570\u636e\u4e2d\u786e\u5b9a\u4f4eAIDPI\u7ec4\u548c\u9ad8AIDPI\u7ec4\u4e4b\u95f4\u54ea\u79cd\u7ec6\u80de\u7c7b\u578b\u8868\u8fbe\u4e86DEGs\uff0c\u5e76\u786e\u5b9aOSA\u7ec6\u80de\u7684\u7279\u5f02\u6027\u6cbb\u7597\u9776\u70b9\uff0c\u8bc4\u4f30\u4e86\u516d\u4e2aOSA\u6d3b\u68c0\u6837\u672c\u7684scRNA-seq\u6570\u636e\u96c6\u3002\u5229\u7528 scGate \u8f6f\u4ef6\u5305\u9274\u5b9a\u4e86 OSA \u7ec4\u7ec7\u4e2d\u7684\u5404\u79cd\u7ec6\u80de\u7c7b\u578b\u3002\u5206\u79bb\u51fa CD45 \u9633\u6027\u7ec6\u80de\uff0c\u5e76\u5c06\u5176\u4e2d 1000 \u4e2a\u4f5c\u4e3a\u9274\u5b9a OSA \u7ec6\u80de\u7684\u53c2\u8003\u7ec6\u80de\u3002\u76f8\u53cd\uff0cCD45 \u9634\u6027\u7684\u7ec6\u80de\u88ab\u8ba4\u4e3a\u662f\u6f5c\u5728\u7684 OSA \u5019\u9009\u7ec6\u80de\u3002\u4f7f\u7528 infercna \u8f6f\u4ef6\u5305\uff0c\u6839\u636e\u6bcf\u4e2a\u67d3\u8272\u4f53\u533a\u57df 150 \u4e2a\u57fa\u56e0\u7684\u5e73\u5747\u8868\u8fbe\u63a8\u65ad\u51fa\u62f7\u8d1d\u6570\u6539\u53d8\uff08CNA\uff09\u3002\u5728\u9884\u6d4b\u7684 OSA \u7ec6\u80de\u4e2d\u89c2\u5bdf\u5230\u4e86\u4e0d\u540c\u7684\u67d3\u8272\u4f53\u6269\u589e\u548c\u7f3a\u5931\uff08\u56fe 4A\uff09\u3002\u4e3a\u4e86\u5b8c\u5584\u7ec6\u80de\u6ce8\u91ca\uff0c\u6211\u4eec\u8bc4\u4f30\u4e86\u9009\u5b9a\u6807\u8bb0\u7269\u7684 mRNA \u8868\u8fbe\u6c34\u5e73\uff1ascGate \u8f6f\u4ef6\u5305\u4fc3\u8fdb\u4e86\u514d\u75ab\u7ec6\u80de\u7684\u81ea\u52a8\u6ce8\u91ca\uff0c\u6700\u7ec8\u53ef\u6ce8\u91ca\u51fa\u4e5d\u4e2a\u4e3b\u8981\u7ec6\u80de\u7fa4\uff08\u56fe 4B\uff09\u3002\u968f\u540e\uff0c\u901a\u8fc7\u6c14\u6ce1\u56fe\uff08\u56fe 4C\uff09\u5c55\u793a\u4e86\u5b9a\u4e49\u6bcf\u4e2a\u7fa4\u7ec4\u7684\u6807\u8bb0\u57fa\u56e0\u53ca\u5176\u8868\u8fbe\u6a21\u5f0f\u3002\u6240\u6709\u5212\u5206\u7684\u7ec6\u80de\u7c7b\u578b\u90fd\u51fa\u73b0\u5728\u516d\u4efd\u6d3b\u68c0\u6837\u672c\u4e2d\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u6839\u636escRNA-seq\u6570\u636e\u96c6\u7684DEA\u7ed3\u679c\uff0c\u7ed8\u5236\u4e86\u6bcf\u4e2a\u7ec6\u80de\u96c6\u7fa4\u7684\u9633\u6027\u8868\u8fbe\u57fa\u56e0\uff08PEGs\uff09\u56fe\uff08\u56fe4D\uff09\uff0c\u663e\u793aCPE\u3001IBSP\u548cCTHRC1\u662fOSA\u7ec6\u80de\u4e2d\u9ad8\u8868\u8fbe\u7684\u524d\u4e09\u4e2a\u57fa\u56e0\u3002\u901a\u8fc7\u6bd4\u8f83\u4f4eAIDPI\u7ec4\u548c\u9ad8AIDPI\u7ec4\u7684DEG\u4e0e\u5404\u7ec6\u80de\u7fa4\u7684PEG\uff0c\u53d1\u73b0\u53ea\u67098%\u7684DEG\u5728OSA\u7ec6\u80de\u4e2d\u4e3b\u8981\u8868\u8fbe\uff08\u56fe4E\uff09\u300212\u4e2a AIDPI \u57fa\u56e0\u4e0e DEGs \u548c PEGs \u7684\u4ea4\u96c6\u7a81\u51fa\u663e\u793a\u4e86\u4e09\u4e2a\u5171\u540c\u7684\u57fa\u56e0\uff08\u56fe 4F\uff09\uff0c\u968f\u540e\u901a\u8fc7\u7279\u5f81\u56fe\u663e\u793a\u4e86\u5b83\u4eec\u7684\u8868\u8fbe\u6a21\u5f0f\uff08\u56fe 4G\uff09\u3002\u6839\u636e canSAR \u6570\u636e\u5e93\uff0c\u53ea\u6709 MYC \u548c SQLE \u7f16\u7801\u7684\u86cb\u767d\u5177\u6709\u53ef\u836f\u7528\u7684\u7ed3\u6784\uff0c\u5e76\u6210\u4e3a\u9ad8 AIDPI \u60a3\u8005\u7684\u6f5c\u5728\u9776\u70b9\u3002<\/span><span style=\"font-size: 10.5pt;text-indent: 0pt;letter-spacing: 0.034em;\">   <\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009432\" data-ratio=\"1.3138888888888889\" data-type=\"jpeg\" data-w=\"1080\" height=\"638 .47998046875\" width=\"545 .6799926757812\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_0PKu2bhhEFzHSib94ezec4xjQIq51w-6.jpg?resize=545%2C638\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx4nVlLy2VdzmE8QLEhKq0qQjoyun8jaq1xB4mrbSPmLRBrex0PKu2bhhEFzHSib94ezec4xjQIq51w\/640?wx_fmt=jpeg'\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe4 \u786e\u5b9a\u9ad8AIDPI\u60a3\u8005\u7684\u6cbb\u7597\u76ee\u6807<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(255, 251, 0);\">5. OSA \u4e2d SQLE \u7684\u8fc7\u8868\u8fbe\u4e0e\u80bf\u7624\u8fdb\u5c55\u76f8\u5173<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">MYC \u8868\u8fbe\u7684\u5347\u9ad8\u4e0e OSA \u7684\u4e0d\u826f\u9884\u540e\u6709\u5173\u3002\u4e0e\u6b63\u5e38\u90bb\u8fd1\u7ec4\u7ec7\u548c\u5047\u5b9a\u7684\u7956\u7ec6\u80de\u76f8\u6bd4\uff0c\u89c2\u5bdf\u5230 SQLE \u5728 OSA \u7ec4\u7ec7\u548c\u7ec6\u80de\u6a21\u578b\u4e2d\u7684\u8868\u8fbe\u660e\u663e\u589e\u52a0\uff08\u56fe 5A,B\uff09\u3002Huvos I\/II\u7ea7\u7684OSA\u6807\u672c\uff08\u8868\u660e\u5bf9\u65b0\u8f85\u52a9\u5316\u7597\u53cd\u5e94\u4e0d\u4f73\uff09\u8868\u73b0\u51faSQLE\u8868\u8fbe\u7684\u5347\u9ad8\uff0c\u4e0e\u6bcd\u672c\u7ec6\u80de\u7cfb\u76f8\u6bd4\uff0c\u5728MTX\u8010\u836f\u7684Saos2\u7ec6\u80de\uff08Saos2\/MTX\uff09\u4e2d\u4e5f\u89c2\u5bdf\u5230\u4e86\u540c\u6837\u7684\u8d8b\u52bf\uff08\u56fe5C\uff09\u3002\u8fd9\u4e9b\u53d1\u73b0\u5f3a\u8c03\u4e86SQLE\u5728OSA\u7684\u8d77\u59cb\u548c\u5316\u7597\u8010\u836f\u6027\u4e2d\u7684\u6f5c\u5728\u610f\u4e49\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86SQLE\u5728OSA\u4e2d\u8fc7\u8868\u8fbe\u7684\u6f5c\u5728\u5206\u5b50\u673a\u5236\u3002\u5728 OSA \u7ec4\u7ec7\u548c\u7ec6\u80de\u7cfb\u4e2d\uff0c\u6211\u4eec\u89c2\u5bdf\u5230 SQLE \u57fa\u56e0\u6c34\u5e73\u62f7\u8d1d\u6570\u4e0e\u5176 mRNA \u8868\u8fbe\u6c34\u5e73\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u7684\u6b63\u76f8\u5173\u6027\uff08\u56fe 5D,E\uff09\u3002\u5728 OSA \u4e2d\u7ecf\u5e38\u6269\u589e\u7684\u764c\u57fa\u56e0 MYC55\uff0c\u5176\u57fa\u56e0\u7ec4\u4f4d\u7f6e\u4e0e SQLE \u76f8\u8fd1\u3002\u5b83\u4eec\u7684\u57fa\u56e0\u62f7\u8d1d\u6570\uff08\u56fe 5F\u3001G\uff09\u548c mRNA \u8868\u8fbe\u6c34\u5e73\uff08\u56fe 5H\uff09\u4e4b\u95f4\u7684\u5f3a\u76f8\u5173\u6027\u8868\u660e\uff0cSQLE \u548c MYC \u540c\u65f6\u6269\u589e\u53ef\u80fd\u5bfc\u81f4\u5b83\u4eec\u5728 OSA \u4e2d\u7684 mRNA \u6c34\u5e73\u5347\u9ad8\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">SQLE \u8868\u8fbe\u7684\u5347\u9ad8\u8fd8\u4e0e\u4eba\u7c7b\u6216\u72ac\u7c7b OSA \u60a3\u8005\u7684\u4e0d\u826f\u9884\u540e\u6709\u5173\uff0c\u591a\u4e2a\u961f\u5217\u7684 KMSA \u8bc1\u5b9e\u4e86\u8fd9\u4e00\u70b9\uff0c\u663e\u793a\u5728\u591a\u4e2a\u4eba\u7c7b\u548c\u72ac\u7c7b OSA \u961f\u5217\u4e2d\uff0c\u9ad8 SQLE \u7ec4\u60a3\u8005\u7684 OS \u6216\u65e0\u4e8b\u4ef6\u751f\u5b58\u7387\u660e\u663e\u8f83\u4f4e\uff08\u56fe 5I-P\uff09\u3002\u6b64\u5916\uff0c\u4f7f\u7528 TMA \u68c0\u6d4b\u4e86 77 \u4f8b\u4eba\u7c7b OSA \u7ec4\u7ec7\u4e2d\u7684 SQLE \u86cb\u767d\u4e30\u5ea6\uff0c\u5e76\u5c55\u793a\u4e86 SQLE \u86cb\u767d\u4f4e\u8868\u8fbe\u548c\u9ad8\u8868\u8fbe\u7684\u4ee3\u8868\u6027\u67d3\u8272\u56fe\u50cf\uff08\u56fe 5Q\uff09\uff0c\u7ed3\u679c\u8bc1\u5b9e SQLE \u86cb\u767d\u9ad8\u8868\u8fbe\u4e0e KMSA \u4e0b OSA \u60a3\u8005\u7684\u4e0d\u826f\u751f\u5b58\u7387\u76f8\u5173\uff08\u56fe 5R\uff09\u3002Meta OSA \u7684\u591a\u53d8\u91cf Cox \u56de\u5f52\u5206\u6790\u8868\u660e\uff0c\u5373\u4f7f\u8c03\u6574\u4e86\u5e74\u9f84\u3001MSTS \u5206\u671f\u548c\u539f\u53d1\u80bf\u7624\u90e8\u4f4d\u7b49\u4e34\u5e8a\u56e0\u7d20\uff0cSQLE mRNA \u8868\u8fbe\u548c MYC mRNA \u8868\u8fbe\u4e5f\u662f OSA \u60a3\u8005\u6b7b\u4ea1\u98ce\u9669\u7684\u72ec\u7acb\u6307\u6807\uff08\u56fe 5S\uff09\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u7531\u4e8eSQLE\u4e0eMYC\u5728DNA\u6c34\u5e73\u4e0a\u5171\u540c\u6269\u589e\uff0cSQLE\u5728OSA\u4e2d\u7684\u8fc7\u5ea6\u8868\u8fbe\u53ef\u901a\u8fc7\u4fc3\u8fdbOSA\u7ec6\u80de\u7684\u5316\u7597\u8010\u53d7\u6027\u548c\u6291\u5236\u6297OSA\u514d\u75ab\u7ec6\u80de\u7684\u6d78\u6da6\u6765\u4fc3\u8fdbOSA\u7684\u8fdb\u5c55\u3002<\/span><span style=\"font-size: 10.5pt;text-indent: 0pt;letter-spacing: 0.034em;\">   <\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009435\" data-ratio=\"1.3138888888888889\" data-type=\"jpeg\" data-w=\"1080\" height=\"631 .1400146484375\" width=\"548 .010009765625\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_yy91RujZWQffeJG1aph7XLulRXe5nA-6.jpg?resize=548%2C631\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx4nVlLy2VdzmE8QLEhKq0qQFn2OWFA6B3Wd0HDItYwYIn8Zyy91RujZWQffeJG1aph7XLulRXe5nA\/640?wx_fmt=jpeg'\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe5 OSA\u4e2dSQLE\u7684\u8fc7\u8868\u8fbe\u4e0e\u80bf\u7624\u7684\u8fdb\u5c55\u6709\u5173<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(255, 251, 0);\">6. \u4f53\u5916\u548c\u4f53\u5185\u6572\u9664SQLE\u963b\u788dOSA\u7684\u53d1\u751f<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u4e3a\u4e86\u63ed\u793aSQLE\u5728OSA\u4e2d\u7684\u4f5c\u7528\uff0c\u6784\u5efa\u4e86\u56db\u79cdshRNA\uff0c\u5e76\u9009\u62e9\u4e86\u6700\u4f73\u7684\u4e00\u79cd\uff0c\u5728\u5185\u6e90\u6027SQLE\u86cb\u767d\u9ad8\u8868\u8fbe\u7684MNNG\u548cU2OS\u7ec6\u80de\uff08\u56fe6A\uff09\u4e2d\u6c89\u9ed8SQLE\u3002\u6572\u9664 SQLE \u6291\u5236\u4e86\u8fd9\u4e9b\u7ec6\u80de\u7684\u6076\u6027\u8868\u578b\uff0c\u5305\u62ec\u589e\u6b96\uff08\u56fe 6B\uff09\u3001\u96c6\u843d\u5f62\u6210\uff08\u56fe 6C\uff09\u3001\u8fc1\u79fb\uff08\u56fe 6D\uff09\u548c\u4fb5\u88ad\uff08\u56fe 6E\uff09\u3002\u6b64\u5916\uff0cSQLE \u57fa\u56e0\u6572\u9664\u53ef\u4fc3\u8fdb\u7ec6\u80de\u51cb\u4ea1\uff08\u56fe 6F,G\uff09\uff0c\u5e76\u63d0\u9ad8\u5bf9\u7531\u5927\u5242\u91cf\u7532\u6c28\u8776\u5464 \uff08MTX\uff09\u3001\u963f\u9709\u7d20 \uff08ADM\uff09 \u548c\u987a\u94c2 \uff08DDP\uff09 \u7ec4\u6210\u7684 MAP \u65b9\u6848\u4e2d\u836f\u7269\u7684\u654f\u611f\u6027\uff0cshSQLE \u7ec4 IC50 \u503c\u7684\u964d\u4f4e\u8bc1\u660e\u4e86\u8fd9\u4e00\u70b9\uff08\u56fe 6H-J\uff09\u3002\u5728\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\uff0c\u53d1\u73b0\u6c89\u9ed8 SQLE \u53ef\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u964d\u4f4e\u80bf\u7624\u91cd\u91cf\u548c\u80c6\u56fa\u9187\u6c34\u5e73\uff08\u56fe 6K-M\uff09\u3002IHC \u5206\u6790\u8bc1\u5b9e\uff0c\u6c89\u9ed8 SQLE \u540e\uff0cSQLE \u86cb\u767d\u4e30\u5ea6\u964d\u4f4e\uff0cKi-67 \u9633\u6027\u7ec6\u80de\u51cf\u5c11\uff08\u56fe 6N\u3001O\uff09\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u9776\u5411 SQLE \u86cb\u767d\u53ef\u80fd\u662f\u6291\u5236 OSA \u7684\u4e00\u79cd\u5408\u7406\u65b9\u6cd5\u3002<\/span><span style=\"font-size: 10.5pt;text-indent: 0pt;letter-spacing: 0.034em;\">   <\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009436\" data-ratio=\"1.3138888888888889\" data-type=\"jpeg\" data-w=\"1080\" height=\"570 .2100219726562\" width=\"553 .47998046875\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_23y2AZICCC6rd6lYBcJ0ZupLNqunCQ-6.jpg?resize=553%2C570\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx4nVlLy2VdzmE8QLEhKq0qQiaBxgZy8PrnYnuDrTZFPk5gaU23y2AZICCC6rd6lYBcJ0ZupLNqunCQ\/640?wx_fmt=jpeg'\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe6 SQLE\u6572\u9664\u963b\u788d\u4e86OSA\u5728\u4f53\u5916\u548c\u4f53\u5185\u7684\u8fdb\u5c55<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(255, 251, 0);\">7. \u6c89\u9ed8SQLE\u53ef\u901a\u8fc7\u964d\u4f4e\u80c6\u56fa\u9187\u548c\u6291\u5236FAK\/PI3K\/Akt\/mTOR\u901a\u8def\u6765\u6291\u5236 OSA<\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u5728\u53d1\u73b0 SQLE \u6c89\u9ed8\u5bf9 OSA \u7684\u4e0d\u5229\u5f71\u54cd\u540e\uff0c\u5c06\u91cd\u70b9\u8f6c\u79fb\u5230\u63ed\u793a\u5176\u6f5c\u5728\u7684\u5206\u5b50\u673a\u5236\u4e0a\u3002\u5bf9\u7a33\u5b9a\u8868\u8fbe shSQLE \u6216 shControl \u7684 U2OS \u7ec6\u80de\u8fdb\u884c\u4e86 RNA \u5e8f\u5217\u5206\u6790\u3002GSEA\u663e\u793a\uff0cSQLE\u6c89\u9ed8\u540e\u80c6\u56fa\u9187\u7a33\u6001\u57fa\u56e0\u7ec4\u660e\u663e\u4e0b\u8c03\uff08\u56fe7A\uff09\uff0c\u8fd9\u4e0e\u53d1\u73b0\u7684SQLE\u6572\u9664\u540eMNNG\u548cU2OS\u7ec6\u80de\u4e2d\u7ec6\u80de\u5185\u80c6\u56fa\u9187\u51cf\u5c11\u7684\u7ed3\u679c\u4e00\u81f4\uff08\u56fe7B\uff09\u3002\u5728\u5bf9 DEGs \u8fdb\u884c KEGG \u5bcc\u96c6\u540e\uff0cPI3K-Akt \u4fe1\u53f7\u901a\u8def\u88ab\u663e\u8457\u5bcc\u96c6\uff0c\u663e\u793a\u51fa\u6700\u9ad8\u7684\u57fa\u56e0\u6bd4\u4f8b\uff08\u56fe 7C\uff09\u3002\u5229\u7528\u5bcc\u96c6\u56fe\u5c06\u5bcc\u96c6\u7684\u672f\u8bed\u6574\u5408\u5230\u4e00\u4e2a\u7f51\u7edc\u4e2d\uff0c\u8868\u660e PI3K-Akt \u4fe1\u53f7\u901a\u8def\u3001\u75c5\u7076\u7c98\u9644\u548c ECM-\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u4e4b\u95f4\u5b58\u5728\u8054\u7cfb\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8fd9\u4e9b\u901a\u8def\u5728 WikiPathways \u6570\u636e\u5e93\u4e2d\u88ab\u5408\u5e76\u6210\u4e00\u4e2a\u66f4\u5e7f\u6cdb\u7684\u57fa\u56e0\u96c6\uff0c\u5373\u5c40\u7076\u7c98\u9644-PI3K-Akt-mTOR \u901a\u8def\uff08WP3932\uff09\uff0c\u5728 U2OS \u7ec6\u80de\u4e2d\u6c89\u9ed8 SQLE \u540e\uff0c\u8be5\u901a\u8def\u4e5f\u540c\u6837\u88ab\u4e0b\u8c03\uff08\u56fe 7D\uff09\u3002SQLE mRNA\u6c34\u5e73\u4e0e\u4e09\u79cdPI3K\/mTOR\u901a\u8def\u62ee\u6297\u5242\u7684AAC\u503c\u6709\u5f88\u5f3a\u7684\u76f8\u5173\u6027\uff08\u56fe7E\uff09\uff0c\u5f3a\u8c03\u4e86SQLE mRNA\u4e0eOSA\u7ec6\u80de\u7cfb\u4e2d\u8be5\u901a\u8def\u6fc0\u6d3b\u4e4b\u95f4\u53ef\u80fd\u5b58\u5728\u7684\u8054\u7cfb\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u8003\u8651\u5230 SQLE \u86cb\u767d\u5728\u80c6\u56fa\u9187\u5408\u6210\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u80c6\u56fa\u9187\u901a\u8fc7\u8102\u8d28\u7b4f\u5728\u7ec6\u80de\u4fe1\u53f7\u8c03\u8282\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff0c\u63a8\u6d4b\u6c89\u9ed8 SQLE \u4f1a\u964d\u4f4e\u7ec6\u80de\u5185\u80c6\u56fa\u9187\u6c34\u5e73\uff0c\u8fdb\u800c\u4f7f FAK\/PI3K\/Akt\/mTOR \u4fe1\u53f7\u901a\u8def\u5931\u6d3b\uff0c\u6700\u7ec8\u6291\u5236 OSA \u7684\u53d1\u5c55\u3002\u4e0e\u8fd9\u4e00\u5047\u8bbe\u76f8\u4e00\u81f4\u7684\u662f\uff0c\u5728 MNNG \u548c U2OS \u7ec6\u80de\u4e2d\u6c89\u9ed8 SQLE \u4f1a\u5bfc\u81f4\u5173\u952e\u86cb\u767d\u7684\u78f7\u9178\u5316\u51cf\u5c11\uff0c\u5305\u62ec\u5c40\u7076\u7c98\u9644\u6fc0\u9176\uff08FAK\uff09\u3001PI3K\u3001Akt \u548c mTOR\u3002\u7136\u800c\uff0c\u8865\u5145\u80c6\u56fa\u9187\u53ef\u6062\u590d\u8fd9\u4e9b\u78f7\u9178\u5316\u6a21\u5f0f\uff08\u56fe 7F\u3001G\uff09\uff0c\u5e76\u62b5\u6d88 SQLE \u6572\u9664\u5bf9\u8fd9\u4e9b OSA \u7ec6\u80de\u6076\u6027\u8868\u578b\u7684\u6291\u5236\u4f5c\u7528\uff08\u56fe 7H-K\uff09\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u6c89\u9ed8SQLE\u53ef\u901a\u8fc7\u964d\u4f4e\u80c6\u56fa\u9187\u6c34\u5e73\u5e76\u968f\u540e\u6291\u5236FAK\/PI3K\/Akt\/mTOR\u901a\u8def\u6765\u6291\u5236OSA\u3002<\/span><span style=\"font-size: 10.5pt;text-indent: 0pt;letter-spacing: 0.034em;\">   <\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009437\" data-ratio=\"1.3138888888888889\" data-type=\"jpeg\" data-w=\"1080\" height=\"650 .2100219726562\" width=\"565 .47998046875\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_bSlHFQicHejoW9nkIa5IzN3TtJej8g-6.jpg?resize=565%2C650\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx4nVlLy2VdzmE8QLEhKq0qQAOIuGKW7t6S8ibT7XeVP0W2jeicbSlHFQicHejoW9nkIa5IzN3TtJej8g\/640?wx_fmt=jpeg'\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe7 SQLE\u6c89\u9ed8\u53ef\u901a\u8fc7\u964d\u4f4e\u80c6\u56fa\u9187\u548c\u6291\u5236FAK\/PI3K\/Akt\/mTOR\u901a\u8def\u6765\u6291\u5236OSA<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(255, 251, 0);\">8. \u836f\u7269\u6291\u5236 SQLE \u53ef\u6291\u5236 OSA \u8fdb\u5c55\u5e76\u63d0\u9ad8\u5316\u7597\u7597\u6548<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u771f\u83cc SQLE \u6291\u5236\u5242\uff08\u5982\u8418\u66ff\u82ac\u548c\u7279\u6bd4\u8418\u82ac\uff09\u5df2\u5728\u591a\u79cd\u764c\u7cfb\u4e2d\u663e\u793a\u51fa\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u4f46\u5728\u7c7b\u4f3c\u6d53\u5ea6\u4e0b\u5bf9\u5065\u5eb7\u6210\u7ea4\u7ef4\u7ec6\u80de\u6ca1\u6709\u5f71\u54cd\u3002MNNG \u548c U2OS \u7ec6\u80de\u5bf9 FR194738 \u7684\u654f\u611f\u6027\u660e\u663e\u589e\u5f3a\uff0cIC50 \u503c\u660e\u663e\u4f4e\u4e8e\u8418\u66ff\u82ac\u548c\u7279\u6bd4\u8418\u82ac\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span>    <o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">FR194738 \u5bf9 U2OS \u548c MNNG \u7ec6\u80de\u7684\u589e\u6b96\u548c\u96c6\u843d\u5f62\u6210\u90fd\u6709\u5242\u91cf\u4f9d\u8d56\u6027\u6291\u5236\u4f5c\u7528\uff08\u56fe 8A,B\uff09\u3002FR194738 \u80fd\u6291\u5236\u80bf\u7624\u751f\u957f\u548c\u80c6\u56fa\u9187\u542b\u91cf\uff0c\u4f46\u4e0d\u4f1a\u5bfc\u81f4\u53d7\u8bd5\u8005\u4f53\u91cd\u51cf\u8f7b\uff08\u56fe 8C-F\uff09\u3002\u89e3\u5256\u80bf\u7624\u91cd\u91cf\u6bd4\u8f83\u663e\u793a\uff0cTGI \u7387\u4e3a 59.67%\uff08\u56fe 8E\uff09\u3002\u6b64\u5916\uff0cKi-67 \u548c\u88c2\u89e3\u7684 caspase-3 \u7684 IHC \u5206\u6790\u8bc1\u5b9e\uff0c\u670d\u7528 FR194738 \u540e\uff0cOSA \u5f02\u79cd\u79fb\u690d\u7269\u7684\u7ec6\u80de\u589e\u6b96\u51cf\u5c11\uff0c\u51cb\u4ea1\u589e\u52a0\uff08\u56fe 8G\u3001H\uff09\uff0c\u8fd9\u7a81\u663e\u4e86 SQLE \u836f\u7406\u6291\u5236\u5bf9 OSA \u7684\u6cbb\u7597\u6f5c\u529b\u3002<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\">\u89c2\u5bdf\u5230 SQLE \u6c89\u9ed8\u4f1a\u4f7f FAK\/PI3K\/Akt\/mTOR \u4fe1\u53f7\u901a\u8def\u5931\u6d3b\uff0c\u800c FAK\/PI3K\/Akt\/mTOR \u4fe1\u53f7\u901a\u8def\u88ab\u6291\u5236\u540e\u4f1a\u589e\u52a0 OSA \u7ec6\u80de\u5bf9MTX\u3001ADM\u548cDDP\u7684\u654f\u611f\u6027\uff0c\u56e0\u6b64\u5047\u8bbe FR194738 \u4e0e\u8fd9\u4e9b\u4e00\u7ebf\u5316\u7597\u836f\u7269\u5728 OSA \u4e2d\u5177\u6709\u534f\u540c\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u4f7f\u7528 MNNG\uff08\u56fe 8I\uff09\u548c U2OS\u8bc4\u4f30\u4e86\u7ec6\u80de\u5bf9\u5404\u79cd\u836f\u7269\u7ec4\u5408\u7684\u53cd\u5e94\u3002\u5927\u591a\u6570\u534f\u540c\u4f5c\u7528\u5f97\u5206\u90fd\u8868\u660e\u5b58\u5728\u5f3a\u5927\u7684\u534f\u540c\u4f5c\u7528\uff08\u56fe 8J,K\uff09\u3002\u9664\u4e86\u534f\u540c\u4f5c\u7528\u5f97\u5206\uff0c\u8fd8\u4f7f\u7528\u7ec4\u5408\u654f\u611f\u6027\u5f97\u5206\uff08CSS\uff09\u6765\u8bc4\u4f30\u836f\u7269\u7ec4\u5408\u7684\u7597\u6548\u3002FR194738 \u548c DDP \u7684\u7ec4\u5408\u662f\u6700\u4f73\u7ec4\u5408\uff08\u56fe 8L,M\uff09\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u901a\u8fc7 FR194738 \u7684 SQLE \u9776\u5411\u4f5c\u7528\uff0c\u5316\u7597\uff08\u5c24\u5176\u662f DDP\uff09\u53ef\u63d0\u9ad8 OSA \u60a3\u8005\u7684\u7597\u6548\u3002\u6839\u636e\u7814\u7a76\u7ed3\u679c\uff0c\u8ba4\u4e3a AIDPI \u5177\u6709\u5bf9 OSA \u60a3\u8005\u8fdb\u884c\u5206\u5c42\u7684\u4e34\u5e8a\u6f5c\u529b\u3002\u867d\u7136\u4f20\u7edf\u7597\u6cd5\u8db3\u4ee5\u6ee1\u8db3\u4f4e AIDPI \u60a3\u8005\u7684\u9700\u6c42\uff0c\u4f46\u9ad8 AIDPI \u60a3\u8005\u53ef\u80fd\u4f1a\u4ece\u7ed3\u5408\u4f20\u7edf\u7597\u6cd5\u548c SQLE \u6291\u5236\u5242\uff08\u5982 FR194738\uff09\u7684\u7efc\u5408\u7597\u6cd5\u4e2d\u83b7\u76ca\uff08\u56fe 8N\uff09\u3002<\/span><span style=\"font-size: 10.5pt;text-indent: 0pt;letter-spacing: 0.034em;\">   <\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><o:page><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009438\" data-ratio=\"1.3138888888888889\" data-type=\"jpeg\" data-w=\"1080\" height=\"628 .8099975585938\" width=\"553 .47998046875\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_OeDABdm3Xcat8CW3ApyuoNloIWXDog-6.jpg?resize=553%2C628\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx4nVlLy2VdzmE8QLEhKq0qQ4h30S5S327HD62WwzX2huI0yOeDABdm3Xcat8CW3ApyuoNloIWXDog\/640?wx_fmt=jpeg'\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-fareast-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u56fe8 SQLE\u6291\u5236\u5242\u53ef\u6291\u5236OSA\u7684\u8fdb\u5c55\u5e76\u63d0\u9ad8\u5316\u7597\u7597\u6548<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;line-height: 1.75em;\"><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;background-color: rgb(120, 172, 254);\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\"><br \/><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;\">\u8be5\u7814\u7a76\u8bc1\u660e\u4e86AIDPI \u662f\u8bc6\u522b OSA \u60a3\u8005\u9ad8\u98ce\u9669\u4e9a\u7fa4\u7684\u53ef\u9760\u751f\u7269\u6807\u5fd7\u7269\u3002SQLE 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\u4e0e\u4e34\u5e8a\u56e0\u7d20\u7ed3\u5408\u5230\u63d0\u540d\u56fe\u4e2d\u53ef\u63d0\u9ad8\u9884\u6d4b\u51c6\u786e\u6027\u3002\u4e3a\u65b9\u4fbf\u7528\u6237\uff0c\u6a21\u578b\u548c\u5217\u7ebf\u56fe\u5747\u53ef\u5728\u7ebf\u8bbf\u95ee\u3002\u9ad8AIDPI\u7ec4\u60a3\u8005\u8868\u73b0\u51fa\u5316\u7597\u62b5\u6297\uff0c\u540c\u65f6\u4f34\u6709MYC\u548cSQLE\u7684\u8fc7\u5ea6\u8868\u8fbe\u3001mTORC1\u4fe1\u53f7\u589e\u5f3a\u3001PI3K-Akt\u4fe1\u53f7\u4e2d\u65ad\u4ee5\u53ca\u514d\u75ab\u6d78\u6da6\u51cf\u5f31\u3002ScRNA-seq\u53d1\u73b0OSA\u7ec6\u80de\u4e2dMYC\u548cSQLE\u7684\u9ad8\u8868\u8fbe\u3002SQLE\u8868\u8fbe\u7684\u5347\u9ad8\u4e0eOSA\u60a3\u8005\u7684\u5316\u7597\u8010\u836f\u6027\u548c\u8f83\u5dee\u7684\u9884\u540e\u76f8\u5173\u3002\u5728\u6cbb\u7597\u4e0a\uff0c\u6c89\u9ed8SQLE\u53ef\u6291\u5236OSA\u6076\u6027\u80bf\u7624\u5e76\u589e\u5f3a\u5316\u7597\u654f\u611f\u6027\uff0c\u8fd9\u662f\u7531\u80c6\u56fa\u9187\u6d88\u8017\u548c\u6291\u5236FAK\/PI3K\/Akt\/mTOR\u901a\u8def\u4ecb\u5bfc\u7684\u3002\u6b64\u5916\uff0cSQLE\u7279\u5f02\u6027\u6291\u5236\u5242FR194738\u5728\u4f53\u5185\u663e\u793a\u51fa\u6297OSA\u4f5c\u7528\uff0c\u5e76\u4e0e\u5316\u7597\u836f\u7269\u4ea7\u751f\u534f\u540c\u6548\u5e94\u3002<\/span><span style=\"font-size:12.0pt;mso-bidi-font-size:12.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-font-kerning:0.0pt;font-weight:bold;\">\u6587\u7ae0\u6574\u5408\u4e86\u591a\u7ec4\u516c\u5171\u6570\u636e\u96c6\uff0c\u53c8\u878d\u5165\u4e86\u81ea\u6709\u6d4b\u5e8f\u961f\u5217\uff0c\u4ee5\u666e\u901a\u8f6c\u5f55\u7ec4\u5206\u6790\u4e3a\u4e3b\uff0c\u5229\u752810\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5101\u79cd\u7ec4\u5408\u6784\u5efa\u9884\u6d4b\u6a21\u578b\uff0c\u903b\u8f91\u4e25\u8c28\u53ef\u9760\uff0c\u53c8\u6709\u5b9e\u9a8c\u9274\u5b9a\u62ff\u4e0b1\u533a10\u5206\u4e0d\u5f97\u4e0d\u4f69\u670d\uff01\uff01<\/span><span style=\"font-size:11.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:\u5b8b\u4f53;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;color:#0070C0;mso-font-kerning:0.0pt;font-weight:bold;mso-bidi-font-weight:bold;\">\uff08ps\uff1a\u53d1\u6587\u8fd8\u7f3a\u597d\u601d\u8def\u7684\u540c\u5b66\u4eec\uff0c\u6b22\u8fce\u6765\u627e\u9986\u957f\uff0c\u8d85\u591a\u65b0\u9896\u7684\u5206\u6790\u601d\u8def\u4f9b\u4f60\u9009\u62e9\u54e6\uff01\uff09<\/span><\/section>\n<section style=\"font-size: 16px;margin-bottom: 0px;\">\n<section powered-by=\"xiumi.us\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;will-change: transform;\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;color: rgb(228, 238, 248);font-size: 26px;\">\n<p><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section powered-by=\"xiumi.us\">\n<section>\n<section powered-by=\"xiumi.us\">\n<section>\n<p>   <\/p>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017417\" data-ratio=\"1\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_B2jkicacLzPjw4xMSqVvoucZjonVDA-9.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg&from=appmsg'\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017419\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_7TvAyUibd1TPhJmZfialJtv6tu2SEg-23.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-recalc-dims=\"1\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100017418\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/14_9N02aBaau07RufXeXRLmvAHsrFZxtw-23.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;margin-bottom: 0px;\"><br \/><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<p><span style=\"font-family: \u7b49\u7ebf;font-size: 10.5pt;letter-spacing: 0.034em;text-indent: 0pt;background-color: rgb(195, 163, 142);\"><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;line-height: 1.75em;\"><o:page><\/o:page><\/section>\n<p style=\"display: none;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d77\u7b2c\u5341\u4eba\u6c11\u533b\u9662\u56e2\u961f\uff1a10\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5101\u79cd\u7ec4\u5408\uff0c10\u4f59\u7ec4\u516c\u5171\u6570\u636e\uff0c\u7ed3\u5408\u5355\u7ec6\u80de\u6570\u636e\uff0c\u4f53\u5185\u5916\u5b9e\u9a8c\u5e26\u4f60\u51b2\u51fb10 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/53709"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=53709"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/53709\/revisions"}],"predecessor-version":[{"id":53724,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/53709\/revisions\/53724"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=53709"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=53709"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=53709"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}