<\/title> \n<meta charset=\"utf-8\"> \n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,maximum-scale=1.0,user-scalable=0,viewport-fit=cover\"><\/p>\n<style>\n*{margin:0;padding:0}html{-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;line-height:1.6}img{z-index:999;position:relative;max-width:100%;margin:10px 0;}body{letter-spacing:.034em}h1,h2,h3,h4,h5,h6{font-weight:400;font-size:16px}a{color:#576b95;text-decoration:none;-webkit-tap-highlight-color:rgba(0,0,0,0)}td,th{word-wrap:break-word;padding:5px 10px;border:1px solid #DDD;}table{margin-bottom:10px;border-collapse:collapse;display:table;width:100%!important;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}.rich_media_area_primary{padding:20px 16px 12px;background-color:#fafafa}@media (max-width:375px){.rich_media_area_primary{padding:20px 60px 15px 60px}.rich_media_area_extra{padding:0 60px 21px 60px}}@media (min-width:1024px){.rich_media_area_primary_inner,.rich_media_area_extra_inner,body{max-width:677px;margin-left:auto;margin-right:auto}.rich_media_area_primary{padding-top:32px}}.rich_media{padding:20px;overflow:hidden;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}@media screen and (min-width:1024px){.rich_media_area_primary_inner,.rich_media_area_extra_inner{max-width:677px;margin-left:auto;margin-right:auto}.rich_media_area_primary{padding-top:32px}}.rich_media_content{overflow:hidden;color:#333;font-size:17px;word-wrap:break-word;-webkit-hyphens:auto;-ms-hyphens:auto;hyphens:auto;text-align:justify;position:relative;z-index:0}.rich_media_content *{max-width:100%!important;box-sizing:border-box!important;-webkit-box-sizing:border-box!important;word-wrap:break-word!important}.rich_media_content p{clear:both;min-height:1em}.rich_media_content em{font-style:italic}.rich_media_content fieldset{min-width:0}.rich_media_content .list-paddingleft-1,.rich_media_content .list-paddingleft-2,.rich_media_content .list-paddingleft-3{padding-left:2.2em}.rich_media_content .list-paddingleft-1 .list-paddingleft-2,.rich_media_content .list-paddingleft-2 .list-paddingleft-2,.rich_media_content .list-paddingleft-3 .list-paddingleft-2{padding-left:30px}.rich_media_content .list-paddingleft-1{padding-left:1.2em}.rich_media_content .list-paddingleft-3{padding-left:3.2em}.rich_media_content .code-snippet,.rich_media_content .code-snippet__fix{max-width:1000%!important}.rich_media_content .code-snippet *,.rich_media_content .code-snippet__fix *{max-width:1000%!important}.rich_media_title{font-size:22px;line-height:1.4;margin-bottom:13px;padding-bottom:13px;border-bottom:1px solid #e7e7eb;}@supports(-webkit-overflow-scrolling:touch){.rich_media_title{font-weight:700}}.rich_media_meta{display:inline-block;vertical-align:middle;padding:0 0 10px 0;font-size:15px;-webkit-tap-highlight-color:rgba(0,0,0,0)}.rich_media_meta.icon_appmsg_tag{margin-right:0px}.rich_media_meta.meta_tag_text{margin-right:0}.rich_media_meta_list em{font-style:normal}.rich_media_meta_text{color:#a5a5a5;}p{margin:0;}.msgBox{margin-top:20px;padding-top:20px;padding-left:50px;overflow:hidden;border-top:2px dashed #09a2ff;}.msg{padding-top:7px;clear:both;}.msgBody{float:right;width:100%;margin-left:55px;padding-bottom:15px;border-bottom:1px dashed #e0e0e0;}.userHeadImg{float:left;margin-left:-50px;}.userHeadImg img{width:40px;height:40px;margin-right:10px;border-radius:3px;}.userName{color:#888888;line-height:24px;font-size:14px;margin:5px 0 5px 0;height:24px;}.replyBody,.autherBody{color:#565656;font-size:15px;}.replyIcon{border-left:4px solid #33ab01;margin-right:5px;}.ad{text-decoration:none;color:#d6d4d4;font-size:12px;}.msgBodyReply{padding-top:5px;}.userName span{float:right;color:#afafaf;font-size:14px;}code{text-align:left;font-size:14px;display:block;white-space:pre;display:-webkit-box;display:-webkit-flex;display:flex;position:relative;}.code-snippet__fix{font-size:14px;margin:10px 0;display:block;color:#333;position:relative;background-color:rgba(0,0,0,0.03);border:1px solid #f0f0f0;border-radius:2px;display:-webkit-box;display:-webkit-flex;display:flex;padding-left:25px;line-height:26px}.code-snippet__fix code{text-align:left;font-size:14px;display:block;white-space:pre;display:-webkit-box;display:-webkit-flex;display:flex;position:relative;font-family:Consolas,\"Liberation 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0;align-items:center}.flex_bd{padding-left:14px;}.account_nickname{display:inline-block;vertical-align:middle;line-height:1.2;color:#576b95;font-size:14px}.account_desc{overflow:hidden;text-overflow:ellipsis;display:-webkit-box;-webkit-box-orient:vertical;-webkit-line-clamp:1;color:rgba(0,0,0,0.3);font-size:14px;line-height:1.2;padding-top:.4em}.msg_source_url{text-align:left;word-break:break-all;margin-top:20px;}.msg_source_url a{padding-right:10px;}.msg_source_url .url_text{color:#a8a8a8;}.video-desc{font-size:14px;margin-top:15px;color:#6c6c6c;}.msg_source_url{text-align:left;}.original_primary_card_tips{color:rgba(0,0,0,0.3);line-height:1.4;font-size:15px;}.weui-flex__item{margin-bottom:20px;padding:20px 16px;margin-top:16px;line-height:1.4;align-items:center;background-color:#f7f7f7;border-radius:8px;position:relative;}.original_primary_desc{color:rgba(0,0,0,0.5);font-size:14px;padding-top:4px;width:auto;overflow:hidden;text-overflow:ellipsis;}.msgBodyReplyList{border-top:1px solid #e1e1e1;margin-top:10px;}.msgBodyReplyListTop{border-top:0;}.reply_like_num{float:right;font-size:14px;color:#c7c7c7;}.msgData{margin-top:20px;color:#626262;}.msgData span{font-size:14px;padding-right:15px;}.msgData .likes{float:right;padding-right:0;}.js_text_content p{font-size:18px;}.rich_media_meta_link{font-size:15px;}blockquote {padding-left: 10px;border-left: 3px solid #dbdbdb;color: rgba(0,0,0,0.5);font-size: 15px;padding-top: 4px;margin: 1em 0;}.video_iframe{width:500px;height:400px;}.blockquote_info{color:#b5b5b5;margin-top:10px;}#copyright_logo{color:#bdbdbd;}.rich_media_meta_list{margin-bottom:10px;}.reprint{background:#efefef;border-radius:5px;padding:8px;color:#1f1f1f;}.reprint a{word-break:break-all;}.topic{color:#8e8e8e;background:#f7f7f7;border-radius:5px;padding:10px 8px;}.topic a{padding-right:5px;}.topic p{margin-bottom:5px;}\n<\/style>\n<link href=\"https:\/\/www.juyifx.cn\/config\/css\/wxArticle.css\" rel=\"stylesheet\"\/>\n<\/head><script>\nvar 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class=\"rich_media_meta_list\">\u5c0f\u9014 <\/span><a href=\"javascript:void(0);\" class=\"wx_tap_link js_wx_tap_highlight weui-wa-hotarea\" id=\"js_name\">\u751f\u4fe1\u679c <\/a><\/span>2024-03-02 19:00:33<\/em><\/div>\n<content><\/p>\n<div class=\"reprint\">\n\u8f6c\u81ea\u516c\u4f17\u53f7\uff1a\u751f\u4fe1\u8def <a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzk0MDQ2MTU0Mg==&mid=2247493129&idx=1&sn=a68c50711a2e6b8d2a1d34729083a60c\" target=\"_blank\" title=\"\u9605\u8bfb\u539f\u6587\" rel=\"noopener\">http:\/\/mp.weixin.qq.com\/s?__biz=Mzk0MDQ2MTU0Mg==&mid=2247493129&idx=1&sn=a68c50711a2e6b8d2a1d34729083a60c<\/a><\/p>\n<\/div>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100015224\" data-ratio=\"0.2222222222222222\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_r0Gd7iaumIGMiaia97aHFV15nrpdzw-89.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxQW8Zek7Noib2uBhB3ZE3yMxI2Hfic7cGTdPYiacicg47jficdr5BVr0Gd7iaumIGMiaia97aHFV15nrpdzw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"900\" style=\"\" \/><\/p>\n\u7532\u57fa\u5316\u662f\u4e00\u79cd\u751f\u7269\u5316\u5b66\u8fc7\u7a0b\uff0c\u6d89\u53ca\u5c06\u7532\u57fa\u57fa\u56e2<\/span>\u6dfb\u52a0\u5230\u5206\u5b50\u7684\u67d0\u4e2a\u90e8\u5206\uff0c\u901a\u5e38\u662f<\/span>DNA\u7684\u80de\u5627\u5576\uff08<\/span>C<\/span>\uff09\u78b1\u57fa\u4e0a\u3002\u8fd9\u4e00\u8fc7\u7a0b\u5728\u751f\u7269\u5b66\u4e2d\u5177\u6709\u91cd\u8981\u610f\u4e49\uff0c\u56e0\u4e3a\u5b83\u53ef\u4ee5\u6539\u53d8<\/span>DNA<\/span>\u7684\u7ed3\u6784\u548c\u529f\u80fd\uff0c\u4ece\u800c\u5f71\u54cd\u57fa\u56e0\u7684\u8868\u8fbe\u3002<\/span><\/span>\u76f8\u5bf9\u4e8e\u516c\u5171\u8f6c\u5f55\u7ec4\u6570\u636e\u7684\u6316\u6398\uff0c\u7532\u57fa\u5316\u6570\u636e\u76f8\u5173\u7684\u751f\u4fe1\u6316\u6398\u8fd8\u5f88\u5c11\u3002<\/span><o:p><\/o:p><\/span><\/p>\n\u4f5c\u8005\u4ece\u516c\u5171\u6570\u636e\u5e93\u6536\u96c6\u4e86\u7532\u57fa\u5316\u6570\u636e\uff0c\u6293\u4f4f\u4e86\u8fd9\u4e9b\u5c11\u6709\u4eba\u6d89\u53ca\u7684\u9886\u57df\uff0c\u5f00\u521b\u4e86\u81ea\u5df1\u7684\u751f\u4fe1\u6316\u6398\u53d1\u6587\u5957\u8def\u3002\u4ec5\u51ed\u501f\u516c\u5171\u6570\u636e\u5e93\u7684\u6570\u636e\uff0c\u7adf\u7136\u53d1\u8868\u4e86<\/span>12\u5206<\/span>+<\/span>\u7684\u9876\u7ea7\u6587\u7ae0\uff01<\/span><\/span>\uff08<\/span>ps\uff1a\u575a\u6301\u548c\u52c7\u6c14\u5c06\u5f15\u9886\u6211\u4eec\u8d70\u5411\u672a\u77e5\u7684\u8f89\u714c\uff0c\u8fd9\u5c31\u662f\u6211\u4eec\u8ffd\u6c42\u7684\u60ca\u559c\uff01\uff09<\/span><\/span><\/strong><\/span>\u5feb\u5750\u7a33\uff0c\u8ba9\u5c0f\u9014\u5e26\u4f60\u4e00\u8d77<\/span>\u63ed\u5f00<\/span>\u8fd9\u7bc7\u9ad8\u5206<\/span>\u7532\u57fa\u5316\u6587\u7ae0\u7684\u9762\u7eb1<\/span>\u2026\u2026<o:p><\/o:p><\/span><\/p>\n\u4f5c\u8005\u9009\u9898\u7684\u89d2\u5ea6\u65b0\u9896\uff0c\u4ece\u7532\u57fa\u5316\u5165\u624b\u8fdb\u884c\u5206\u6790\uff0c\u4f7f\u7528\u516c\u5171\u6570\u636e\u5e93\u4e2d\u7532\u57fa\u5316\u6570\u636e\u5f00\u53d1\u4e86<\/span>CimpleG<\/span>\u3002\u8fd9\u662f\u4e00\u79cd\u7528\u4e8e\u5bfb\u627e<\/span>CpG\u7532\u57fa\u5316\u7684\u65b0\u9896\u65b9\u6cd5\u3002\u4f5c\u8005\u8be6\u7ec6\u63cf\u8ff0\u4e86<\/span>CimpleG<\/span>\u7684\u8ba1\u7b97\u5206\u6790\u3001\u6e90\u4ee3\u7801\u7f16\u5199\u3001<\/span>CpG<\/span>\u7b7e\u540d\u7684\u6ce8\u91ca\u7b49\u65b9\u9762\u7684\u65b9\u6cd5\u548c\u6280\u672f\u3002<\/span>CimpleG<\/span>\u4e3a\u5bfb\u627e<\/span>CpG<\/span>\u7532\u57fa\u5316\u7b7e\u540d\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u9896\u4e14\u6709\u6548\u7684\u65b9\u6cd5\uff0c<\/span><\/span>\u4e3a\u7406\u89e3<\/span>DNA\u7532\u57fa\u5316\u5728\u4eba\u7c7b\u5065\u5eb7\u548c\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u3002<\/span><\/span>\u5728\u5c0f\u9014\u770b\u8fc7\u7684\u6587\u732e\u4e2d\uff0c\u8fd9\u7bc7\u6587\u7ae0\u7684\u4f5c\u8005\u7edd\u5bf9\u5c5e\u4e8e\u5728\u751f\u4fe1\u6316\u6398\u65b9\u9762\u7684\u9ad8\u624b\uff0c\u5df2\u7ecf\u4e0d\u6ee1\u8db3\u4e8e\u7b80\u5355\u7684\u751f\u4fe1\u5957\u8def\uff0c\u8d70\u4e0a\u4e86\u5f00\u53d1\u7b97\u6cd5\u7684\u9053\u8def\u3002\u5bf9\u4e8e\u4e0d\u6ee1\u8db3\u4e8e\u4f20\u7edf\u751f\u4fe1\u5206\u6790\u5957\u8def\u7684\u5c0f\u4f19\u4f34\uff0c\u8fd9\u7bc7\u6587\u7ae0\u7684\u601d\u8def\u503c\u5f97\u501f\u9274\uff01\u4f60\u53ea\u9700\u4ece\u8fd9\u4e9b\u516c\u5171\u6570\u636e\u5e93\u4e2d\u83b7\u53d6\u6240\u9700\u7684\u6570\u636e\uff0c\u9009\u4e2a\u65b0\u7684\u89d2\u5ea6\uff0c\u5c31\u80fd\u8d70\u51fa\u751f\u4fe1\u5185\u5377\uff01<\/span><\/p>\n<p style=\"outline: 0px;font-family: system-ui, -apple-system, "system-ui", "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);visibility: visible;margin-bottom: 24px;\">\uff08PS\uff1a\u6ca1\u6709\u601d\u8def\u3001\u4e0d\u77e5\u9053\u600e\u4e48\u521b\u65b0\u7684\u5b9d\u5b50\u4eec\uff0c\u8bb0\u5f97\u6765\u627e\u5c0f\u9014\u54e6\uff0c\u8d85\u591a\u4e2a\u6027\u5316\u601d\u8def\u7b49\u4f60\u6765\u62ff\uff01\uff09<\/span><\/strong><\/span><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017023\" data-ratio=\"1\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-38.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 163px;height: 163px;\" \/><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100009360\" data-ratio=\"0.3537037037037037\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_jzO4X0MoHdz6t5RhnnicibIblj6amg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQc8jOdnNxFINl30EGmRvfxHeqsvme4K1ELRcNeR33eCM9EKljzO4X0MoHdz6t5RhnnicibIblj6amg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"1080\" style=\"\" \/><\/p>\n\u9898\u76ee\uff1a<\/span>CimpleG\uff1a\u5bfb\u627e\u7b80\u5355\u7684 <\/span>CpG <\/span>\u7532\u57fa\u5316\u7279\u5f81<\/span><\/span><o:p><\/o:p><\/span><\/p>\n\u6742\u5fd7\uff1a<\/span>GENOME BIOLOGY<\/span><\/em><o:p><\/o:p><\/span><\/em><\/p>\n\u5f71\u54cd\u56e0\u5b50\uff1a<\/span>I<\/span><\/span>F=12.3<\/span><o:p><\/o:p><\/span><\/p>\n\u53d1\u8868\u65f6\u95f4\uff1a<\/span>2<\/span><\/span>023<\/span>\u5e74<\/span>7<\/span>\u6708<\/span><\/p>\n<span style=\"outline: 0px;font-size: 16px;letter-spacing: 0.034em;text-wrap: wrap;background-color: rgb(255, 255, 255);font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;\"><\/span><\/span><\/p>\n\u7814\u7a76\u80cc\u666f<\/span><\/strong><\/span><o:p><\/o:p><\/span><\/strong><\/p>\nDNA\u7532\u57fa\u5316\uff08<\/span>DNAm<\/span>\uff09\u4e0e\u67d3\u8272\u8d28\u7ed3\u6784\u3001\u7ec6\u80de\u5206\u5316\u6709\u5173\uff0c\u5e76\u63a7\u5236\u57fa\u56e0\u8868\u8fbe\u3002\u7531\u4e8e\u5176\u7a33\u5b9a\u6027\u548c\u51c6\u786e\u6027\uff0c<\/span>DNAm<\/span>\u6210\u4e3a\u9884\u6d4b\u5e74\u9f84\u548c\u764c\u75c7\u5206\u5c42\u7684\u5f3a\u5927\u5206\u5b50\u6807\u8bb0\uff0c\u5e76\u53ef\u7528\u4e8e\u7ec6\u80de\u7c7b\u578b\u8868\u5f81\u548c\u7ec6\u80de\u89e3\u5377\u79ef\u3002<\/span>Illumina BeadChips<\/span>\u53ef\u6d4b\u91cf\u591a\u8fbe<\/span>850,000<\/span>\u4e2a<\/span>CpG<\/span>\u4f4d\u70b9\u7684<\/span>DNAm<\/span>\u56fe\u8c31\uff0c\u4f46\u591a<\/span>CpG<\/span>\u6574\u5408\u53ef\u80fd\u963b\u788d\u4e34\u5e8a\u5e94\u7528\u3002\u5355\u4e2a<\/span>CpG<\/span>\u7684\u9776\u5411\u5206\u6790\u53ef\u80fd\u66f4\u6709\u5229\u3002<\/span>DNAm<\/span>\u7279\u5f81\u7684\u68c0\u6d4b\u901a\u5e38\u4f7f\u7528\u7edf\u8ba1\u6d4b\u8bd5\uff0c\u4f8b\u5982\u5f39\u6027\u7f51\uff0c\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u7b49\u3002\u6709\u51e0\u79cd\u4e13\u6ce8\u4e8e\u57fa\u4e8e\u53c2\u8003\u7684\u7ec6\u80de\u53cd\u5377\u79ef\u95ee\u9898\u7684\u65b9\u6cd5\uff0c\u4f8b\u5982\u4f7f\u7528<\/span>t<\/span>\u7edf\u8ba1\u3001\u975e\u7ebf\u6027\u968f\u673a\u6548\u5e94\u6a21\u578b\u7b49\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u65b9\u6cd5\u5728\u7ec6\u80de\u53cd\u5377\u79ef\u548c<\/span>DNAm<\/span>\u7279\u5f81\u9884\u6d4b\u65b9<\/span><\/span>\u9762\u6210\u529f\uff0c\u4f46\u7f3a\u4e4f\u9002\u5408\u9009\u62e9\u5c0f<\/span>DNAm\u7279\u5f81\u7684\u8ba1\u7b97\u65b9\u6cd5\u3002\u6700\u8fd1\u7684\u7814\u7a76\u63cf\u8ff0\u4e86\u4f7f\u7528\u5c11\u6570<\/span>CpG<\/span>\u4f4d\u70b9\u8fdb\u884c\u7ec6\u80de\u7c7b\u578b\u53cd\u5377\u79ef\uff0c\u5e76\u63d0\u51fa\u4e86\u540d\u4e3a<\/span>CimpleG<\/span>\u7684\u8ba1\u7b97\u6846\u67b6\uff0c\u7528\u4e8e\u68c0\u6d4b\u5c0f<\/span>CpG<\/span>\u7532\u57fa\u5316\u7279\u5f81\uff0c\u9002\u7528\u4e8e\u7ec6\u80de\u7c7b\u578b\u5206\u7c7b\u548c\u7ec6\u80de\u6df7\u5408\u7269\u53cd\u5377\u79ef\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n\u6570\u636e\u6765\u6e90<\/span><\/strong><\/span><o:p><\/o:p><\/span><\/strong><\/p>\n<table cellspacing=\"0\" width=\"426\">\n<tbody>\n<tr>\n<td width=\"76\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(91, 155, 213);border-right: none;border-top-width: 1pt;border-top-color: rgb(91, 155, 213);border-bottom-width: 1pt;border-bottom-color: rgb(91, 155, 213);background: rgb(91, 155, 213);\">\n\u6570\u636e\u96c6<\/span>\/\u961f\u5217<\/span><\/span><\/strong><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"70\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right: none;border-top-width: 1pt;border-top-color: rgb(91, 155, 213);border-bottom-width: 1pt;border-bottom-color: rgb(91, 155, 213);background: rgb(91, 155, 213);\">\n\u6570\u636e\u5e93<\/span><\/strong><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"99\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right: none;border-top-width: 1pt;border-top-color: rgb(91, 155, 213);border-bottom-width: 1pt;border-bottom-color: rgb(91, 155, 213);background: rgb(91, 155, 213);\">\n\u6570\u636e\u7c7b\u578b<\/span><\/strong><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"179\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-width: 1pt;border-color: rgb(91, 155, 213) rgb(91, 155, 213) rgb(91, 155, 213) rgb(156, 194, 229);background: rgb(91, 155, 213);\">\n\u8be6\u7ec6\u4fe1\u606f<\/span><\/strong><o:p><\/o:p><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"76\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\">\nGSE103253<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"70\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\">\nGEO<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"99\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\">\n\u7532\u57fa\u5316\u6570\u636e<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"179\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\">\n245<\/span>\u4f8b\u60a3\u8005<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"76\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGSE107226<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"70\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGEO<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"99\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n\u7532\u57fa\u5316\u6570\u636e<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"179\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n12<\/span>\u4f8b\u60a3\u8005<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"76\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGSE40699<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"70\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGEO<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"99\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n\u7532\u57fa\u5316\u6570\u636e<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"179\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n62<\/span>\u4f8b\u60a3\u8005<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"76\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGSE41933<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"70\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGEO<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"99\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n\u7532\u57fa\u5316\u6570\u636e<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"179\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n12<\/span>\u4f8b\u60a3\u8005<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"76\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGSE43976<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"70\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGEO<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"99\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n\u7532\u57fa\u5316\u6570\u636e<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"179\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n95<\/span>\u4f8b\u60a3\u8005<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\u7814\u7a76\u601d\u8def<\/span><\/strong><\/span><o:p><\/o:p><\/span><\/strong><\/p>\n\u6587\u7ae0\u7684\u7814\u7a76\u601d\u8def\u4e3b\u8981\u96c6\u4e2d\u5728\u901a\u8fc7<\/span>IDOL\u7684\u8bad\u7ec3\u8fc7\u7a0b\u6765\u9009\u62e9\u548c\u4f18\u5316<\/span>DNAm<\/span>\u7b7e\u540d\u7684\u63a2\u9488\uff0c\u5206\u4e3a\u4e24\u4e2a\u6b65\u9aa4\uff1a\u9996\u5148\u57fa\u4e8e\u6570\u636e\u5bf9\u6bd4\u8fdb\u884c<\/span>t<\/span>\u68c0\u9a8c\u9009\u62e9\u5019\u9009\u63a2\u9488\uff0c\u7136\u540e\u901a\u8fc7\u8fed\u4ee3\u65b9\u6cd5\u4f18\u5316\u63a2\u9488\u9009\u62e9\uff0c\u89e3\u51b3\u7ec6\u80de\u6df7\u5408\u53bb\u5377\u79ef\u95ee\u9898\u3002\u6b64\u5916\uff0c\u8fd8\u6d89\u53ca<\/span>DNAm<\/span>\u7b7e\u540d\u7684\u7cbe\u70bc\uff0c\u4f7f\u7528\u4eba\u5de5\u6df7\u5408\u7684<\/span>12<\/span>\u79cd\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u6570\u636e\uff0c\u5e76\u4e0e\u7eaf\u5316\u7684\u767d\u7ec6\u80de\u6570\u636e\u8fdb\u884c\u76f8\u540c\u7684\u9884\u5904\u7406\u3002\u6267\u884c\u65f6\u95f4\u65b9\u9762\uff0c<\/span>IDOL<\/span>\u7684\u4f18\u5316\u6b65\u9aa4\u53ef\u80fd\u8f83\u957f\uff0c\u4e0e<\/span>CimpleG.10<\/span>\u76f8\u6bd4\uff0c\u6267\u884c\u65f6\u95f4\u660e\u663e\u4e0d\u540c\u3002\u6587\u7ae0\u8fd8\u63a2\u8ba8\u4e86<\/span>EpiDISH<\/span>\u65b9\u6cd5\uff0c\u4e00\u79cd\u4e13\u95e8\u9488\u5bf9\u7ec6\u80de\u6df7\u5408\u53bb\u5377\u79ef\u95ee\u9898\u7684\u65b9\u6cd5\uff0c\u5229\u7528<\/span>DNAse<\/span>\u654f\u611f\u4f4d\u70b9\u7684\u4fe1\u606f\u548c\u5176\u4ed6\u7eaf\u5316\u8840\u7ec6\u80de\u6570\u636e\u8fdb\u884c\u53bb\u5377\u79ef<\/span><\/span>\u3002\u8fd9\u4e9b\u6b65\u9aa4\u548c\u65b9\u6cd5\u5171\u540c\u6784\u6210\u4e86\u4e00\u79cd\u7efc\u5408\u7684\u7814\u7a76\u65b9\u6cd5\uff0c\u6db5\u76d6\u4e86\u5019\u9009\u63a2\u9488\u7684\u9009\u62e9\u3001\u8fed\u4ee3\u4f18\u5316\u3001\u6df7\u5408\u6570\u636e\u96c6\u7684\u4f7f\u7528\u3001\u4e0d\u540c\u7b97\u6cd5\u7684\u6bd4\u8f83\u548c\u6267\u884c\u65f6\u95f4\u7684\u5206\u6790\u7b49\u591a\u4e2a\u65b9\u9762\u3002<\/span><o:p><\/o:p><\/span><\/p>\n\u4e3b\u8981\u7ed3\u679c<\/span><\/strong><\/span><o:p><\/o:p><\/span><\/strong><\/p>\n1<\/span><\/span><\/strong>. CimpleG\u6846\u67b6<\/span><\/span><\/strong><o:p><\/o:p><\/span><\/strong><\/p>\nCimpleG\u662f\u4e00\u4e2a\u8ba1\u7b97\u6846\u67b6\uff0c\u7528\u4e8e\u9009\u62e9\u7528\u4e8e\u7ec6\u80de\u7c7b\u578b\u5206\u7c7b\u7684<\/span>DNAm<\/span>\u7279\u5f81\uff08\u56fe <\/span>1 A<\/span>\uff09\u3002\u8be5\u6846\u67b6\u4f7f\u7528<\/span>t<\/span>\u7edf\u8ba1\u5206\u6570\u548c\u7cbe\u786e\u53ec\u56de\u66f2\u7ebf <\/span>(AUPR) <\/span>\u4e0b\u7684\u9762\u79ef\u6765\u8fdb\u884c\u7279\u5f81\u9009\u62e9\uff0c\u4ee5\u89e3\u51b3<\/span>DNAm<\/span>\u7ec6\u80de\u5206\u7c7b\u95ee\u9898\u4e2d\u7c7b\u522b\u7684\u9ad8\u5ea6\u4e0d\u5e73\u8861\u3002<\/span>CimpleG<\/span>\u8fd8\u7ed3\u5408\u5206\u6570\u548c<\/span>AUPR<\/span>\u503c\u6765\u9009\u62e9\u6700\u4f73\u5019\u9009<\/span>CpG<\/span>\u4f4d\u70b9\uff0c\u5e76\u6784\u5efa\u5355\u53d8\u91cf\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u5206\u7c7b\u5668\u548c\u7ec6\u80de\u53cd\u5377\u79ef\uff08\u56fe <\/span>1 A<\/span>\uff09\u3002\u5b83\u8fd8\u652f\u6301\u66ff\u4ee3\u7279\u5f81\u9009\u62e9\u548c\u5206\u7c7b\u65b9\u6cd5\uff0c\u4f8b\u5982\u968f\u673a\u68ee\u6797\u3001\u5f39\u6027\u7f51\u7edc\u548c\u63d0\u5347\u6811 <\/span>(XGBoost)<\/span>\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\nCimpleG\u8fd8\u63d0\u4f9b\u4e86\u4e24\u4e2a\u7cbe\u5fc3\u7b56\u5212\u548c\u9884\u5904\u7406\u7684<\/span>DNAm<\/span>\u6570\u636e\u96c6\uff0c\u5305\u62ec<\/span>14<\/span>\u79cd\u4f53\u7ec6\u80de\u7c7b\u578b\u548c<\/span>8<\/span>\u79cd\u4e0d\u540c\u767d\u7ec6\u80de\u7684<\/span>DNAm<\/span>\u9635\u5217\u6982\u8981\uff08\u56fe <\/span>1 B-C<\/span>\uff09\u3002\u8fd9\u4e9b\u6570\u636e\u96c6\u5305\u62ec<\/span>576<\/span>\u4e2a\u548c<\/span>365<\/span>\u4e2a\u6837\u672c\uff0c\u5177\u6709<\/span>143,291<\/span>\u548c<\/span>284,706<\/span>\u4e2a<\/span>CpG<\/span>\u4f4d\u70b9\uff0c\u5e76\u8fdb\u884c\u4e86\u72ec\u7acb\u9884\u5904\u7406\u4ee5\u907f\u514d\u6cc4\u6f0f\u9884\u5904\u7406\u3002\u4e3b\u6210\u5206\u5206\u6790\u663e\u793a\u4e3b\u8981\u7ec6\u80de\u7c7b\u578b\u4e4b\u95f4\u5b58\u5728\u5206\u79bb\uff0c\u800c\u5bc6\u5207\u76f8\u5173\u7684\u7ec6\u80de\u5219\u9700\u8981\u9644\u52a0<\/span>PC<\/span>\u8fdb\u884c\u533a\u5206\uff08\u56fe<\/span>1 B-C<\/span>\uff09\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100009361\" data-ratio=\"0.9536423841059603\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_STxc3JHxvMqSpprDMTZA3h0aY9llQQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQc8jOdnNxFINl30EGmRvfxvU6gFlicUTYwzoj4edF8NG1EMSTxc3JHxvMqSpprDMTZA3h0aY9llQQ\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"755\" style=\"\" \/><\/p>\n\u56fe<\/span>1 CimpleG\u6846\u67b6<\/span><\/span><o:p><\/o:p><\/span><\/p>\n2. <\/span><\/strong>\u7ec6\u80de\u7c7b\u578b\u9884\u6d4b\u95ee\u9898\u7684\u57fa\u51c6\u6d4b\u8bd5<\/span><\/strong><o:p><\/o:p><\/span><\/strong><\/p>\nCimpleG\u4e0e\u5176\u4ed6\u751f\u6210\u8868\u89c2\u9057\u4f20\u7279\u5f81\u7684\u65b9\u6cd5\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u5305\u62ec\u51b3\u7b56\u6811\u3001\u968f\u673a\u68ee\u6797\u3001\u63d0\u5347\u6811\u3001\u795e\u7ecf\u7f51\u7edc\u548c\u5f39\u6027\u7f51\u7edc\u3002\u4e00\u4e9b\u6a21\u578b\u7531\u4e8e\u9ad8\u7ef4\u7279\u5f81\u5927\u5c0f\u800c\u65e0\u6cd5\u5e94\u5bf9\u6570\u636e\u96c6\uff0c\u56e0\u6b64\u6267\u884c\u4e86\u65e0\u76d1\u7763\u7279\u5f81\u9009\u62e9\u4f5c\u4e3a\u9884\u8bad\u7ec3\u6b65\u9aa4\u3002\u901a\u8fc7\u4ea4\u53c9\u9a8c\u8bc1\u6846\u67b6\u4f18\u5316\u4e86\u6240\u6709\u65b9\u6cd5\u7684\u53c2\u6570\uff0c\u5e76\u8bc4\u4f30\u4e86\u5206\u7c7b\u6027\u80fd\u3001\u8ba1\u7b97\u65f6\u95f4\u548c\u6bcf\u4e2a\u6a21\u578b\u4f7f\u7528\u7684\u7279\u5f81\u6570\u91cf\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n\u5728\u4f53\u7ec6\u80de\u548c\u767d\u7ec6\u80de\u6570\u636e\u96c6\u4e0a\uff0c<\/span>Elastic Net\u3001<\/span>CimpleG<\/span>\u548c<\/span>CimpleG<\/span>\uff08\u5206\u6570\uff09\u5177\u6709\u6700\u9ad8\u7684\u4e2d\u503c<\/span>AUPR<\/span>\uff08\u56fe <\/span>2 A-B<\/span>\uff09\uff0c\u8868\u660e\u8fd9\u4e9b\u662f\u6027\u80fd\u6700\u597d\u7684\u6a21\u578b\u3002\u8fd9\u4e9b\u65b9\u6cd5\u5728\u6b63\u6837\u672c\u6570\u91cf\u4e0a\u5177\u6709\u7a33\u5b9a\u7684<\/span>AUPR<\/span>\u503c\uff0c\u8868\u660e\u5b83\u4eec\u5bf9\u4e8e\u5c11\u91cf\u6b63\u6837\u672c\u800c\u8a00\u5177\u6709\u7a33\u5065\u6027\u3002\u5173\u4e8e\u8ba1\u7b97\u65f6\u95f4\uff0c<\/span>CimpleG<\/span>\u5e73\u5747\u9700\u8981<\/span>55.3<\/span>\u79d2\uff0c<\/span>Elastic Net<\/span>\u5e73\u5747\u9700\u8981<\/span>37.6<\/span>\u5206\u949f\uff0c\u800c\u66b4\u529b\u7b97\u6cd5\u5e73\u5747\u9700\u8981<\/span>6.61<\/span>\u5c0f\u65f6\u6765\u751f\u6210\u7b7e\u540d\uff08\u56fe <\/span>2<\/span><\/span> <\/span>C-D\uff09\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u8fd9\u4e09\u79cd\u65b9\u6cd5\u5728\u57fa\u4e8e<\/span>DNAm<\/span>\u7684\u7ec6\u80de\u5206\u7c7b\u95ee\u9898\u4e2d\u8868\u73b0\u540c\u6837\u51fa\u8272\uff0c\u800c<\/span>CimpleG<\/span>\u4e3a\u7279\u5f81\u9009\u62e9\u95ee\u9898\u63d0\u4f9b\u4e86\u663e\u7740\u7684\u52a0\u901f\u3002<\/span><\/span>\uff08<\/span>ps\uff1a<\/span><\/span>\u4e0d\u4f1a\u4f5c\u56fe\u600e\u4e48\u529e\uff1f\u53ef\u4ee5\u4f7f\u7528<\/span>\u6211\u4eec\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u5b9e\u73b0\uff0c\u4e91\u751f\u4fe1\u5206\u6790\u5de5\u5177\u5e73\u53f0\u5305\u542b\u8d85\u591a\u96f6\u4ee3\u7801\u5206\u6790\u548c\u7ed8\u56fe\u5c0f\u5de5\u5177\uff0c\u4e0a\u4f20\u6570\u636e\u4e00\u952e\u51fa\u56fe\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u6765\u5c1d\u8bd5\u54df\uff0c\u7f51\u5740\uff1a<\/span>http:\/\/www.biocloudservice.com\/home.html\uff09\u3002<\/span><\/span><\/span><\/strong><o:p><\/o:p><\/span><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100009362\" data-ratio=\"0.9195402298850575\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_vGSaUxpzcXrla3OqRodjyOZfpMh8Rg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQc8jOdnNxFINl30EGmRvfxtQJTmuQRVz7iafTnjDKa05Bib8vGSaUxpzcXrla3OqRodjyOZfpMh8Rg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"783\" style=\"\" \/><\/p>\n\u56fe<\/span>2 <\/span>\u7ec6\u80de\u7c7b\u578b\u9884\u6d4b\u95ee\u9898\u7684\u57fa\u51c6\u6d4b\u8bd5<\/span><o:p><\/o:p><\/span><\/p>\n3. DNA\u7532\u57fa\u5316\u4f4d\u70b9\u7684\u9009\u62e9<\/span><\/span><\/strong><o:p><\/o:p><\/span><\/strong><\/p>\nElastic Net\u9009\u62e9\u4e86\u6700\u5927\u6570\u91cf\u7684\u7279\u5f81\uff0c\u5176\u4e2d\u767d\u7ec6\u80de\u7684\u6240\u6709\u516d\u4e2a\u6a21\u578b\u4e2d\u6709<\/span>3378<\/span>\u4e2a\u72ec\u7279\u7279\u5f81\uff08\u56fe<\/span>3A<\/span>\uff09\uff0c\u4f53\u7ec6\u80de\u7684\u6240\u6709\u5341\u4e2a\u6a21\u578b\u4e2d\u6709<\/span>2345<\/span>\u4e2a\u72ec\u7279\u7279\u5f81\u3002\u5355\u7279\u5f81\u5206\u7c7b\u5668\uff08<\/span>CimpleG<\/span>\u548c<\/span>Brute force<\/span>\uff09\u4e3a\u4f53\u7ec6\u80de\u548c\u767d\u7ec6\u80de\u6570\u636e\u9009\u62e9\u4e86\u603b\u5171<\/span>10<\/span>\u4e2a\u548c<\/span>6<\/span>\u4e2a<\/span>DNAm<\/span>\u4f4d\u70b9\u3002<\/span>CimpleG<\/span>\u9009\u62e9\u7684\u6240\u6709<\/span>16<\/span>\u4e2a<\/span>DNAm<\/span>\u4e5f\u662f<\/span>Elastic Net<\/span>\u9009\u62e9\u7684<\/span>DNAm<\/span>\u4f4d\u70b9\u7684\u4e00\u90e8\u5206\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n\u89c2\u5bdf<\/span>CimpleG\u751f\u6210\u7684\u7279\u5b9a\u7279\u5f81\u4e5f\u5f88\u6709\u8da3\uff08\u56fe<\/span>3B-G<\/span>\uff09\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u57fa\u56e0\u7ec4\u4f4d\u7f6e\u53ef\u4ee5\u63d0\u4f9b\u5bf9\u7ec6\u80de\u672c\u8eab\u7684\u751f\u7269\u5b66\u6d1e\u5bdf\u3002\u4f8b\u5982\uff0c\u9009\u62e9\u9760\u8fd1<\/span>CD4<\/span>\uff08<\/span>cg05044173<\/span>\uff0c\u56fe<\/span>3C<\/span>\uff09\u548c<\/span>CD8<\/span>\uff08<\/span>cg04329870<\/span>\uff0c\u56fe<\/span>3D<\/span>\uff09\u57fa\u56e0\u7684<\/span>DNAm<\/span>\u4f4d\u70b9\u4f5c\u4e3a<\/span>CD4+<\/span>\u548c<\/span>CD8+T<\/span>\u7ec6\u80de\u7684\u6807\u8bb0\uff0c\u4ee5\u53ca\u9009\u62e9\u4f53\u5185\u7684<\/span>LIPE<\/span>\uff08\u8102\u80aa\u9176<\/span>E<\/span>\uff0c\u6fc0\u7d20\u654f\u611f\u578b\uff09\u4f5c\u4e3a\u8102\u80aa\u7ec6\u80de\u7684\u6807\u8bb0\u7269\u7684<\/span>DNAm<\/span>\u7ad9\u70b9\uff08<\/span>cg01537765<\/span>\uff09\u3002\u8fd8\u9009\u62e9\u4e86\u4e0a\u76ae\u95f4\u8d28\u8f6c\u5316\u76f8\u5173\u8f6c\u5f55\u56e0\u5b50<\/span>TWIST1<\/span>\u542f\u52a8\u5b50\u4e2d\u7684<\/span>CpG<\/span>\uff08<\/span>cg10624122<\/span>\uff09<\/span><\/span>\u4f5c\u4e3a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u6807\u8bb0\uff0c\u4ee5\u53ca\u5176\u4ed6\u4e0e\u5177\u6709\u7ec6\u80de\u7279\u5f02\u6027\u8868\u8fbe\u6a21\u5f0f\u7684\u57fa\u56e0\u63a5\u8fd1\u7684<\/span>CpG\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n\u6700\u540e\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u767d\u7ec6\u80de\u6570\u636e\u4e2d\u4f7f\u7528\u7684\u4e00\u4e9b\u6837\u672c\u6765\u81ea\u8110\u5e26\u8840\u6216\u975e\u5065\u5eb7\u6837\u672c\uff0c\u4f46\u5728\u5206\u6790\u4e2d\uff0c\u6ca1\u6709\u4efb\u4f55\u534f\u53d8\u91cf\u4f1a\u5f71\u54cd<\/span>CimpleG\u5bfc\u51fa\u7684\u7b7e\u540d\u7684<\/span>DNAm<\/span>\u503c\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100009363\" data-ratio=\"0.7236180904522613\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_J1BBv0R0RXxLsZqMbOHibnZctGnpTA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQc8jOdnNxFINl30EGmRvfxsQZJiaFjgJbj8RqL3YxMiafp5ZFJ1BBv0R0RXxLsZqMbOHibnZctGnpTA\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"995\" style=\"\" \/><\/p>\n\u56fe<\/span>3<\/span> <\/span>DNA\u7532\u57fa\u5316\u4f4d\u70b9\u7684\u9009\u62e9<\/span><\/span><o:p><\/o:p><\/span><\/p>\n4. <\/span><\/strong>\u7ec6\u80de\u7c7b\u578b\u53cd\u5377\u79ef\u95ee\u9898\u7684\u57fa\u51c6\u6d4b\u8bd5<\/span><\/strong><o:p><\/o:p><\/span><\/strong><\/p>\n\u6211\u4eec\u8bc4\u4f30\u4e86\u767d\u7ec6\u80de\u4e2d\u7ec6\u80de\u53cd\u5377\u79ef\u95ee\u9898\u7684<\/span>DNAm\u7279\u5f81\u548c\u6a21\u578b\u9884\u6d4b\uff0c\u4f7f\u7528\u4e86\u4e0d\u540c\u7684\u65b9\u6cd5\u548c\u7b97\u6cd5\u3002\u5728\u8003\u8651\u4e3b\u8981\u767d\u7ec6\u80de\u7684\u53cd\u5377\u79ef\u95ee\u9898\u65f6\uff0c<\/span>IDOL<\/span>\u5177\u6709\u6700\u9ad8\u6392\u540d\uff0c\u5176\u6b21\u662f\u5177\u6709<\/span>10<\/span>\u4e2a<\/span>CpG<\/span>\u7684<\/span>CimpleG<\/span>\u548c<\/span>minfi<\/span>\uff08\u56fe<\/span>4<\/span>\uff09\u3002\u5728\u57fa\u4e8e\u5c0f\u7b7e\u540d\u7684\u65b9\u6cd5\u4e2d\uff0c<\/span>CimpleG<\/span>\u7684<\/span>RMSE<\/span>\u901a\u5e38\u4f4e\u4e8e\u7ade\u4e89\u65b9\u6cd5\u3002\u6211\u4eec\u8fd8\u5728\u4e24\u4e2a\u4eba\u5de5\u6df7\u5408\u6570\u636e\u96c6\u4e0a\u8bc4\u4f30\u4e86\u4e00\u7cfb\u5217\u65b9\u6cd5\uff0c\u5176\u4e2d<\/span>IDOL<\/span>\u83b7\u5f97\u4e86\u6700\u4f4e\u7684<\/span>RMSE<\/span>\uff0c\u5176\u6b21\u662f\u5177\u6709<\/span>10<\/span>\u4e2a<\/span>CpG<\/span>\u7684<\/span>CimpleG<\/span>\uff0c\u6bcf\u79cd\u7ec6\u80de\u7c7b\u578b\u5177\u6709\u5355\u4e2a<\/span>CpG<\/span>\u7684<\/span>CimpleG<\/span>\u83b7\u5f97\u4e86\u6700\u4f4e\u7684\u5e73\u5747<\/span>RMSE<\/span>\u3002<\/span>CimpleG<\/span>\u4ec5\u9700\u8981<\/span>12<\/span>\u4e2a\u4f4d\u70b9\uff0c\u800c\u5176\u4ed6\u65b9\u6cd5\u9700\u8981\u66f4\u591a\u7684<\/span>DNAm<\/span>\u4f4d\u70b9\u3002<\/span>CimpleG<\/span>\u6240\u9700\u7684<\/span>DNAm<\/span>\u4f4d\u70b9\u6bd4\u6027\u80fd\u6700\u4f73\u7684\u65b9\u6cd5<\/span>IDOL<\/span>\u3001<\/span>CimpleG.10<\/span>\u548c<\/span>minfi<\/span>\u81f3\u5c11\u5c11<\/span>10<\/span>\u500d\u3002\u603b\u7684\u6765\u8bf4\uff0c<\/span>CimpleG<\/span>\u662f\u4e00\u79cd\u6709\u7ade\u4e89\u529b\u7684\u7ec6\u80de\u53cd\u5377\u79ef\u65b9\u6cd5\uff0c\u540c\u65f6\u4e5f\u662f\u5c0f\u7279\u5f81\u7684\u6700\u4f73\u6267\u884c\u65b9\u6cd5\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100009364\" data-ratio=\"1.1388888888888888\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_oicSibgPP8lbvYAuuCeB558fMFsbZQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQc8jOdnNxFINl30EGmRvfx7ZuG0UVc2iaPkhZSOluwFdJZ8GOoicSibgPP8lbvYAuuCeB558fMFsbZQ\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"720\" style=\"\" \/><\/p>\n\u56fe<\/span>4 <\/span>\u7ec6\u80de\u7c7b\u578b\u53cd\u5377\u79ef\u95ee\u9898\u7684\u57fa\u51c6\u6d4b\u8bd5<\/span><o:p><\/o:p><\/span><\/p>\n\u6587\u7ae0\u5c0f\u7ed3<\/span><\/strong><\/span><o:p><\/o:p><\/span><\/strong><\/p>\n\u8fd9\u7bc7\u6587\u7ae0\u4ece\u7532\u57fa\u5316\u89d2\u5ea6\u51fa\u53d1\uff0c\u6784\u5efa\u4e86<\/span>CimpleG\u7684\u8ba1\u7b97\u6846\u67b6\uff0c\u7528\u4e8e\u68c0\u6d4b\u5c0f\u578b<\/span>CpG<\/span>\u7532\u57fa\u5316\u7279\u5f81\uff0c\u7279\u522b\u662f\u5728\u7ec6\u80de\u7c7b\u578b\u5206\u7c7b\u548c\u7ec6\u80de\u6df7\u5408\u7269\u53cd\u5377\u79ef\u65b9\u9762\u3002<\/span>CimpleG<\/span><\/span>\u662f<\/span>\u4e00\u79cd\u65b0\u9896\u7684\u65b9\u6cd5\uff0c\u901a\u8fc7\u5c06<\/span>t\u7edf\u8ba1\u91cf\u4e0e\u7cbe\u786e\u53ec\u56de\u66f2\u7ebf\u4e0b\u9762\u79ef\uff08<\/span>AUPR<\/span>\uff09\u76f8\u7ed3\u5408\uff0c\u4f7f\u7528\u5355\u53d8\u91cf\u7279\u5f81\u9009\u62e9\u6765\u9009\u62e9\u7528\u4e8e\u7ec6\u80de\u7c7b\u578b\u5206\u7c7b\u7684\u6700\u4f73<\/span>DNAm<\/span>\u4f4d\u70b9\u3002\u4e0e\u73b0\u6709\u7684<\/span>IDOL<\/span>\u548c<\/span>EpiDISH<\/span>\u65b9\u6cd5\u76f8\u6bd4\uff0c<\/span>CimpleG<\/span>\u5728\u6267\u884c\u65f6\u95f4\u548c\u51c6\u786e\u6027\u65b9\u9762\u8868\u73b0\u51fa\u8272\u3002\u6b64\u5916\uff0c<\/span>CimpleG<\/span>\u7684\u7075\u6d3b\u6027\u548c\u6548\u7387\u4f7f\u5176\u9002\u7528\u4e8e\u9700\u8981\u5feb\u901f\u3001\u6807\u51c6\u5316\u548c\u7ecf\u6d4e\u9ad8\u6548\u5206\u6790\u7684\u4e34\u5e8a\u73af\u5883\u3002\u603b\u7684\u6765\u8bf4\uff0c<\/span>CimpleG<\/span>\u7684\u521b\u65b0\u6027\u5728<\/span><\/span>\u4e8e\u5176\u72ec\u7279\u7684\u8ba1\u7b97\u65b9\u6cd5\u548c\u5e7f\u6cdb\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u4e3a\u5bfb\u627e\u548c\u5229\u7528<\/span>CpG\u7532\u57fa\u5316\u7b7e\u540d\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u548c\u5de5\u5177\u3002<\/span><\/span>\u679c\u7136\u7a81\u7834\u751f\u4fe1\u5185\u5377\u7684\u529e\u6cd5\u5c31\u662f\u4ece\u7b97\u6cd5\u51fa\u53d1\uff0c\u4f5c\u8005\u7684\u4ee3\u7801\u548c\u7b97\u6cd5\u529f\u529b\u624e\u5b9e\uff0c\u8fd8\u4ece\u5c11\u6709\u4eba\u6d89\u53ca\u7684\u7532\u57fa\u5316\u51fa\u53d1\uff0c\u80fd\u53d1<\/span>1<\/span><\/span>2<\/span>\u5206<\/span>+<\/span>\u7684\u6587\u7ae0\u53ef\u8c13\u662f\u5b9e\u81f3\u540d\u5f52\u3002\u5728\u8fd9\u4e9b\u7b97\u6cd5\u7684\u57fa\u7840\u4e0a\u52a0\u4ee5\u6539\u8fdb\uff0c\u6587\u7ae0\u7684\u521b\u65b0\u6027\u5f88\u9ad8\uff0c\u9ad8\u5206\u671f\u520a\u7684\u8ba4\u53ef\u5ea6\u4e5f\u9ad8\u3002\u5728\u7b97\u6cd5\u4e0a\u6709\u4e00\u4e9b\u57fa\u7840\u7684\u5c0f\u4f19\u4f34\u4eec\u8d76\u7d27\u5b66\u8d77\u6765\u5427\uff01<\/span><\/span>\uff08\u5982\u679c\u4f60\u8fd8\u4e0d\u77e5\u9053\u5982\u4f55\u5c06\u6539\u8fdb\u7b97\u6cd5\uff0c\u6216\u8005\u6ca1\u6709\u601d\u8def\uff0c\u5c31\u8d76\u7d27\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\u6765\u54a8\u8be2\u5c0f\u9014\u5427\uff01\uff09<\/span><\/strong><\/span><\/p>\n\u5c0f\u679c\u8fd8\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n <\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017027\" data-ratio=\"1\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-38.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'&from=appmsg\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n <\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017028\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_7TvAyUibd1TPhJmZfialJtv6tu2SEg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100017029\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_9N02aBaau07RufXeXRLmvAHsrFZxtw.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;text-wrap: wrap;\" \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" 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class=\"rich_media_meta_list\">\u5c0f\u9014 <\/span><a href=\"javascript:void(0);\" class=\"wx_tap_link js_wx_tap_highlight weui-wa-hotarea\" id=\"js_name\">\u751f\u4fe1\u679c <\/a><\/span>2024-03-02 19:00:33<\/em><\/div>\n<content><\/p>\n<div class=\"reprint\">\n\u8f6c\u81ea\u516c\u4f17\u53f7\uff1a\u751f\u4fe1\u8def <a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzk0MDQ2MTU0Mg==&mid=2247493129&idx=1&sn=a68c50711a2e6b8d2a1d34729083a60c\" target=\"_blank\" title=\"\u9605\u8bfb\u539f\u6587\" rel=\"noopener\">http:\/\/mp.weixin.qq.com\/s?__biz=Mzk0MDQ2MTU0Mg==&mid=2247493129&idx=1&sn=a68c50711a2e6b8d2a1d34729083a60c<\/a><\/p>\n<\/div>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100015224\" data-ratio=\"0.2222222222222222\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_r0Gd7iaumIGMiaia97aHFV15nrpdzw-89.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxQW8Zek7Noib2uBhB3ZE3yMxI2Hfic7cGTdPYiacicg47jficdr5BVr0Gd7iaumIGMiaia97aHFV15nrpdzw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"900\" style=\"\" \/><\/p>\n\u7532\u57fa\u5316\u662f\u4e00\u79cd\u751f\u7269\u5316\u5b66\u8fc7\u7a0b\uff0c\u6d89\u53ca\u5c06\u7532\u57fa\u57fa\u56e2<\/span>\u6dfb\u52a0\u5230\u5206\u5b50\u7684\u67d0\u4e2a\u90e8\u5206\uff0c\u901a\u5e38\u662f<\/span>DNA\u7684\u80de\u5627\u5576\uff08<\/span>C<\/span>\uff09\u78b1\u57fa\u4e0a\u3002\u8fd9\u4e00\u8fc7\u7a0b\u5728\u751f\u7269\u5b66\u4e2d\u5177\u6709\u91cd\u8981\u610f\u4e49\uff0c\u56e0\u4e3a\u5b83\u53ef\u4ee5\u6539\u53d8<\/span>DNA<\/span>\u7684\u7ed3\u6784\u548c\u529f\u80fd\uff0c\u4ece\u800c\u5f71\u54cd\u57fa\u56e0\u7684\u8868\u8fbe\u3002<\/span><\/span>\u76f8\u5bf9\u4e8e\u516c\u5171\u8f6c\u5f55\u7ec4\u6570\u636e\u7684\u6316\u6398\uff0c\u7532\u57fa\u5316\u6570\u636e\u76f8\u5173\u7684\u751f\u4fe1\u6316\u6398\u8fd8\u5f88\u5c11\u3002<\/span><o:p><\/o:p><\/span><\/p>\n\u4f5c\u8005\u4ece\u516c\u5171\u6570\u636e\u5e93\u6536\u96c6\u4e86\u7532\u57fa\u5316\u6570\u636e\uff0c\u6293\u4f4f\u4e86\u8fd9\u4e9b\u5c11\u6709\u4eba\u6d89\u53ca\u7684\u9886\u57df\uff0c\u5f00\u521b\u4e86\u81ea\u5df1\u7684\u751f\u4fe1\u6316\u6398\u53d1\u6587\u5957\u8def\u3002\u4ec5\u51ed\u501f\u516c\u5171\u6570\u636e\u5e93\u7684\u6570\u636e\uff0c\u7adf\u7136\u53d1\u8868\u4e86<\/span>12\u5206<\/span>+<\/span>\u7684\u9876\u7ea7\u6587\u7ae0\uff01<\/span><\/span>\uff08<\/span>ps\uff1a\u575a\u6301\u548c\u52c7\u6c14\u5c06\u5f15\u9886\u6211\u4eec\u8d70\u5411\u672a\u77e5\u7684\u8f89\u714c\uff0c\u8fd9\u5c31\u662f\u6211\u4eec\u8ffd\u6c42\u7684\u60ca\u559c\uff01\uff09<\/span><\/span><\/strong><\/span>\u5feb\u5750\u7a33\uff0c\u8ba9\u5c0f\u9014\u5e26\u4f60\u4e00\u8d77<\/span>\u63ed\u5f00<\/span>\u8fd9\u7bc7\u9ad8\u5206<\/span>\u7532\u57fa\u5316\u6587\u7ae0\u7684\u9762\u7eb1<\/span>\u2026\u2026<o:p><\/o:p><\/span><\/p>\n\u4f5c\u8005\u9009\u9898\u7684\u89d2\u5ea6\u65b0\u9896\uff0c\u4ece\u7532\u57fa\u5316\u5165\u624b\u8fdb\u884c\u5206\u6790\uff0c\u4f7f\u7528\u516c\u5171\u6570\u636e\u5e93\u4e2d\u7532\u57fa\u5316\u6570\u636e\u5f00\u53d1\u4e86<\/span>CimpleG<\/span>\u3002\u8fd9\u662f\u4e00\u79cd\u7528\u4e8e\u5bfb\u627e<\/span>CpG\u7532\u57fa\u5316\u7684\u65b0\u9896\u65b9\u6cd5\u3002\u4f5c\u8005\u8be6\u7ec6\u63cf\u8ff0\u4e86<\/span>CimpleG<\/span>\u7684\u8ba1\u7b97\u5206\u6790\u3001\u6e90\u4ee3\u7801\u7f16\u5199\u3001<\/span>CpG<\/span>\u7b7e\u540d\u7684\u6ce8\u91ca\u7b49\u65b9\u9762\u7684\u65b9\u6cd5\u548c\u6280\u672f\u3002<\/span>CimpleG<\/span>\u4e3a\u5bfb\u627e<\/span>CpG<\/span>\u7532\u57fa\u5316\u7b7e\u540d\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u9896\u4e14\u6709\u6548\u7684\u65b9\u6cd5\uff0c<\/span><\/span>\u4e3a\u7406\u89e3<\/span>DNA\u7532\u57fa\u5316\u5728\u4eba\u7c7b\u5065\u5eb7\u548c\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u3002<\/span><\/span>\u5728\u5c0f\u9014\u770b\u8fc7\u7684\u6587\u732e\u4e2d\uff0c\u8fd9\u7bc7\u6587\u7ae0\u7684\u4f5c\u8005\u7edd\u5bf9\u5c5e\u4e8e\u5728\u751f\u4fe1\u6316\u6398\u65b9\u9762\u7684\u9ad8\u624b\uff0c\u5df2\u7ecf\u4e0d\u6ee1\u8db3\u4e8e\u7b80\u5355\u7684\u751f\u4fe1\u5957\u8def\uff0c\u8d70\u4e0a\u4e86\u5f00\u53d1\u7b97\u6cd5\u7684\u9053\u8def\u3002\u5bf9\u4e8e\u4e0d\u6ee1\u8db3\u4e8e\u4f20\u7edf\u751f\u4fe1\u5206\u6790\u5957\u8def\u7684\u5c0f\u4f19\u4f34\uff0c\u8fd9\u7bc7\u6587\u7ae0\u7684\u601d\u8def\u503c\u5f97\u501f\u9274\uff01\u4f60\u53ea\u9700\u4ece\u8fd9\u4e9b\u516c\u5171\u6570\u636e\u5e93\u4e2d\u83b7\u53d6\u6240\u9700\u7684\u6570\u636e\uff0c\u9009\u4e2a\u65b0\u7684\u89d2\u5ea6\uff0c\u5c31\u80fd\u8d70\u51fa\u751f\u4fe1\u5185\u5377\uff01<\/span><\/p>\n<p style=\"outline: 0px;font-family: system-ui, -apple-system, "system-ui", "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);visibility: visible;margin-bottom: 24px;\">\uff08PS\uff1a\u6ca1\u6709\u601d\u8def\u3001\u4e0d\u77e5\u9053\u600e\u4e48\u521b\u65b0\u7684\u5b9d\u5b50\u4eec\uff0c\u8bb0\u5f97\u6765\u627e\u5c0f\u9014\u54e6\uff0c\u8d85\u591a\u4e2a\u6027\u5316\u601d\u8def\u7b49\u4f60\u6765\u62ff\uff01\uff09<\/span><\/strong><\/span><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017023\" data-ratio=\"1\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-38.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 163px;height: 163px;\" \/><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100009360\" data-ratio=\"0.3537037037037037\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_jzO4X0MoHdz6t5RhnnicibIblj6amg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQc8jOdnNxFINl30EGmRvfxHeqsvme4K1ELRcNeR33eCM9EKljzO4X0MoHdz6t5RhnnicibIblj6amg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"1080\" style=\"\" \/><\/p>\n\u9898\u76ee\uff1a<\/span>CimpleG\uff1a\u5bfb\u627e\u7b80\u5355\u7684 <\/span>CpG <\/span>\u7532\u57fa\u5316\u7279\u5f81<\/span><\/span><o:p><\/o:p><\/span><\/p>\n\u6742\u5fd7\uff1a<\/span>GENOME BIOLOGY<\/span><\/em><o:p><\/o:p><\/span><\/em><\/p>\n\u5f71\u54cd\u56e0\u5b50\uff1a<\/span>I<\/span><\/span>F=12.3<\/span><o:p><\/o:p><\/span><\/p>\n\u53d1\u8868\u65f6\u95f4\uff1a<\/span>2<\/span><\/span>023<\/span>\u5e74<\/span>7<\/span>\u6708<\/span><\/p>\n<span style=\"outline: 0px;font-size: 16px;letter-spacing: 0.034em;text-wrap: wrap;background-color: rgb(255, 255, 255);font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;\"><\/span><\/span><\/p>\n\u7814\u7a76\u80cc\u666f<\/span><\/strong><\/span><o:p><\/o:p><\/span><\/strong><\/p>\nDNA\u7532\u57fa\u5316\uff08<\/span>DNAm<\/span>\uff09\u4e0e\u67d3\u8272\u8d28\u7ed3\u6784\u3001\u7ec6\u80de\u5206\u5316\u6709\u5173\uff0c\u5e76\u63a7\u5236\u57fa\u56e0\u8868\u8fbe\u3002\u7531\u4e8e\u5176\u7a33\u5b9a\u6027\u548c\u51c6\u786e\u6027\uff0c<\/span>DNAm<\/span>\u6210\u4e3a\u9884\u6d4b\u5e74\u9f84\u548c\u764c\u75c7\u5206\u5c42\u7684\u5f3a\u5927\u5206\u5b50\u6807\u8bb0\uff0c\u5e76\u53ef\u7528\u4e8e\u7ec6\u80de\u7c7b\u578b\u8868\u5f81\u548c\u7ec6\u80de\u89e3\u5377\u79ef\u3002<\/span>Illumina BeadChips<\/span>\u53ef\u6d4b\u91cf\u591a\u8fbe<\/span>850,000<\/span>\u4e2a<\/span>CpG<\/span>\u4f4d\u70b9\u7684<\/span>DNAm<\/span>\u56fe\u8c31\uff0c\u4f46\u591a<\/span>CpG<\/span>\u6574\u5408\u53ef\u80fd\u963b\u788d\u4e34\u5e8a\u5e94\u7528\u3002\u5355\u4e2a<\/span>CpG<\/span>\u7684\u9776\u5411\u5206\u6790\u53ef\u80fd\u66f4\u6709\u5229\u3002<\/span>DNAm<\/span>\u7279\u5f81\u7684\u68c0\u6d4b\u901a\u5e38\u4f7f\u7528\u7edf\u8ba1\u6d4b\u8bd5\uff0c\u4f8b\u5982\u5f39\u6027\u7f51\uff0c\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u7b49\u3002\u6709\u51e0\u79cd\u4e13\u6ce8\u4e8e\u57fa\u4e8e\u53c2\u8003\u7684\u7ec6\u80de\u53cd\u5377\u79ef\u95ee\u9898\u7684\u65b9\u6cd5\uff0c\u4f8b\u5982\u4f7f\u7528<\/span>t<\/span>\u7edf\u8ba1\u3001\u975e\u7ebf\u6027\u968f\u673a\u6548\u5e94\u6a21\u578b\u7b49\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u65b9\u6cd5\u5728\u7ec6\u80de\u53cd\u5377\u79ef\u548c<\/span>DNAm<\/span>\u7279\u5f81\u9884\u6d4b\u65b9<\/span><\/span>\u9762\u6210\u529f\uff0c\u4f46\u7f3a\u4e4f\u9002\u5408\u9009\u62e9\u5c0f<\/span>DNAm\u7279\u5f81\u7684\u8ba1\u7b97\u65b9\u6cd5\u3002\u6700\u8fd1\u7684\u7814\u7a76\u63cf\u8ff0\u4e86\u4f7f\u7528\u5c11\u6570<\/span>CpG<\/span>\u4f4d\u70b9\u8fdb\u884c\u7ec6\u80de\u7c7b\u578b\u53cd\u5377\u79ef\uff0c\u5e76\u63d0\u51fa\u4e86\u540d\u4e3a<\/span>CimpleG<\/span>\u7684\u8ba1\u7b97\u6846\u67b6\uff0c\u7528\u4e8e\u68c0\u6d4b\u5c0f<\/span>CpG<\/span>\u7532\u57fa\u5316\u7279\u5f81\uff0c\u9002\u7528\u4e8e\u7ec6\u80de\u7c7b\u578b\u5206\u7c7b\u548c\u7ec6\u80de\u6df7\u5408\u7269\u53cd\u5377\u79ef\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n\u6570\u636e\u6765\u6e90<\/span><\/strong><\/span><o:p><\/o:p><\/span><\/strong><\/p>\n<table cellspacing=\"0\" width=\"426\">\n<tbody>\n<tr>\n<td width=\"76\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(91, 155, 213);border-right: none;border-top-width: 1pt;border-top-color: rgb(91, 155, 213);border-bottom-width: 1pt;border-bottom-color: rgb(91, 155, 213);background: rgb(91, 155, 213);\">\n\u6570\u636e\u96c6<\/span>\/\u961f\u5217<\/span><\/span><\/strong><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"70\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right: none;border-top-width: 1pt;border-top-color: rgb(91, 155, 213);border-bottom-width: 1pt;border-bottom-color: rgb(91, 155, 213);background: rgb(91, 155, 213);\">\n\u6570\u636e\u5e93<\/span><\/strong><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"99\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right: none;border-top-width: 1pt;border-top-color: rgb(91, 155, 213);border-bottom-width: 1pt;border-bottom-color: rgb(91, 155, 213);background: rgb(91, 155, 213);\">\n\u6570\u636e\u7c7b\u578b<\/span><\/strong><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"179\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-width: 1pt;border-color: rgb(91, 155, 213) rgb(91, 155, 213) rgb(91, 155, 213) rgb(156, 194, 229);background: rgb(91, 155, 213);\">\n\u8be6\u7ec6\u4fe1\u606f<\/span><\/strong><o:p><\/o:p><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"76\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\">\nGSE103253<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"70\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\">\nGEO<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"99\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\">\n\u7532\u57fa\u5316\u6570\u636e<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"179\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\">\n245<\/span>\u4f8b\u60a3\u8005<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"76\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGSE107226<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"70\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGEO<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"99\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n\u7532\u57fa\u5316\u6570\u636e<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"179\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n12<\/span>\u4f8b\u60a3\u8005<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"76\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGSE40699<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"70\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGEO<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"99\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n\u7532\u57fa\u5316\u6570\u636e<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"179\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n62<\/span>\u4f8b\u60a3\u8005<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"76\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGSE41933<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"70\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGEO<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"99\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n\u7532\u57fa\u5316\u6570\u636e<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"179\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n12<\/span>\u4f8b\u60a3\u8005<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"76\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGSE43976<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"70\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\nGEO<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"99\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n\u7532\u57fa\u5316\u6570\u636e<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<td width=\"179\" valign=\"top\" style=\"padding: 0pt 5.4pt;border-left-width: 1pt;border-left-color: rgb(156, 194, 229);border-right-width: 1pt;border-right-color: rgb(156, 194, 229);border-top: none;border-bottom-width: 1pt;border-bottom-color: rgb(156, 194, 229);\">\n95<\/span>\u4f8b\u60a3\u8005<\/span><o:p><\/o:p><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\u7814\u7a76\u601d\u8def<\/span><\/strong><\/span><o:p><\/o:p><\/span><\/strong><\/p>\n\u6587\u7ae0\u7684\u7814\u7a76\u601d\u8def\u4e3b\u8981\u96c6\u4e2d\u5728\u901a\u8fc7<\/span>IDOL\u7684\u8bad\u7ec3\u8fc7\u7a0b\u6765\u9009\u62e9\u548c\u4f18\u5316<\/span>DNAm<\/span>\u7b7e\u540d\u7684\u63a2\u9488\uff0c\u5206\u4e3a\u4e24\u4e2a\u6b65\u9aa4\uff1a\u9996\u5148\u57fa\u4e8e\u6570\u636e\u5bf9\u6bd4\u8fdb\u884c<\/span>t<\/span>\u68c0\u9a8c\u9009\u62e9\u5019\u9009\u63a2\u9488\uff0c\u7136\u540e\u901a\u8fc7\u8fed\u4ee3\u65b9\u6cd5\u4f18\u5316\u63a2\u9488\u9009\u62e9\uff0c\u89e3\u51b3\u7ec6\u80de\u6df7\u5408\u53bb\u5377\u79ef\u95ee\u9898\u3002\u6b64\u5916\uff0c\u8fd8\u6d89\u53ca<\/span>DNAm<\/span>\u7b7e\u540d\u7684\u7cbe\u70bc\uff0c\u4f7f\u7528\u4eba\u5de5\u6df7\u5408\u7684<\/span>12<\/span>\u79cd\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u6570\u636e\uff0c\u5e76\u4e0e\u7eaf\u5316\u7684\u767d\u7ec6\u80de\u6570\u636e\u8fdb\u884c\u76f8\u540c\u7684\u9884\u5904\u7406\u3002\u6267\u884c\u65f6\u95f4\u65b9\u9762\uff0c<\/span>IDOL<\/span>\u7684\u4f18\u5316\u6b65\u9aa4\u53ef\u80fd\u8f83\u957f\uff0c\u4e0e<\/span>CimpleG.10<\/span>\u76f8\u6bd4\uff0c\u6267\u884c\u65f6\u95f4\u660e\u663e\u4e0d\u540c\u3002\u6587\u7ae0\u8fd8\u63a2\u8ba8\u4e86<\/span>EpiDISH<\/span>\u65b9\u6cd5\uff0c\u4e00\u79cd\u4e13\u95e8\u9488\u5bf9\u7ec6\u80de\u6df7\u5408\u53bb\u5377\u79ef\u95ee\u9898\u7684\u65b9\u6cd5\uff0c\u5229\u7528<\/span>DNAse<\/span>\u654f\u611f\u4f4d\u70b9\u7684\u4fe1\u606f\u548c\u5176\u4ed6\u7eaf\u5316\u8840\u7ec6\u80de\u6570\u636e\u8fdb\u884c\u53bb\u5377\u79ef<\/span><\/span>\u3002\u8fd9\u4e9b\u6b65\u9aa4\u548c\u65b9\u6cd5\u5171\u540c\u6784\u6210\u4e86\u4e00\u79cd\u7efc\u5408\u7684\u7814\u7a76\u65b9\u6cd5\uff0c\u6db5\u76d6\u4e86\u5019\u9009\u63a2\u9488\u7684\u9009\u62e9\u3001\u8fed\u4ee3\u4f18\u5316\u3001\u6df7\u5408\u6570\u636e\u96c6\u7684\u4f7f\u7528\u3001\u4e0d\u540c\u7b97\u6cd5\u7684\u6bd4\u8f83\u548c\u6267\u884c\u65f6\u95f4\u7684\u5206\u6790\u7b49\u591a\u4e2a\u65b9\u9762\u3002<\/span><o:p><\/o:p><\/span><\/p>\n\u4e3b\u8981\u7ed3\u679c<\/span><\/strong><\/span><o:p><\/o:p><\/span><\/strong><\/p>\n1<\/span><\/span><\/strong>. CimpleG\u6846\u67b6<\/span><\/span><\/strong><o:p><\/o:p><\/span><\/strong><\/p>\nCimpleG\u662f\u4e00\u4e2a\u8ba1\u7b97\u6846\u67b6\uff0c\u7528\u4e8e\u9009\u62e9\u7528\u4e8e\u7ec6\u80de\u7c7b\u578b\u5206\u7c7b\u7684<\/span>DNAm<\/span>\u7279\u5f81\uff08\u56fe <\/span>1 A<\/span>\uff09\u3002\u8be5\u6846\u67b6\u4f7f\u7528<\/span>t<\/span>\u7edf\u8ba1\u5206\u6570\u548c\u7cbe\u786e\u53ec\u56de\u66f2\u7ebf <\/span>(AUPR) <\/span>\u4e0b\u7684\u9762\u79ef\u6765\u8fdb\u884c\u7279\u5f81\u9009\u62e9\uff0c\u4ee5\u89e3\u51b3<\/span>DNAm<\/span>\u7ec6\u80de\u5206\u7c7b\u95ee\u9898\u4e2d\u7c7b\u522b\u7684\u9ad8\u5ea6\u4e0d\u5e73\u8861\u3002<\/span>CimpleG<\/span>\u8fd8\u7ed3\u5408\u5206\u6570\u548c<\/span>AUPR<\/span>\u503c\u6765\u9009\u62e9\u6700\u4f73\u5019\u9009<\/span>CpG<\/span>\u4f4d\u70b9\uff0c\u5e76\u6784\u5efa\u5355\u53d8\u91cf\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u5206\u7c7b\u5668\u548c\u7ec6\u80de\u53cd\u5377\u79ef\uff08\u56fe <\/span>1 A<\/span>\uff09\u3002\u5b83\u8fd8\u652f\u6301\u66ff\u4ee3\u7279\u5f81\u9009\u62e9\u548c\u5206\u7c7b\u65b9\u6cd5\uff0c\u4f8b\u5982\u968f\u673a\u68ee\u6797\u3001\u5f39\u6027\u7f51\u7edc\u548c\u63d0\u5347\u6811 <\/span>(XGBoost)<\/span>\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\nCimpleG\u8fd8\u63d0\u4f9b\u4e86\u4e24\u4e2a\u7cbe\u5fc3\u7b56\u5212\u548c\u9884\u5904\u7406\u7684<\/span>DNAm<\/span>\u6570\u636e\u96c6\uff0c\u5305\u62ec<\/span>14<\/span>\u79cd\u4f53\u7ec6\u80de\u7c7b\u578b\u548c<\/span>8<\/span>\u79cd\u4e0d\u540c\u767d\u7ec6\u80de\u7684<\/span>DNAm<\/span>\u9635\u5217\u6982\u8981\uff08\u56fe <\/span>1 B-C<\/span>\uff09\u3002\u8fd9\u4e9b\u6570\u636e\u96c6\u5305\u62ec<\/span>576<\/span>\u4e2a\u548c<\/span>365<\/span>\u4e2a\u6837\u672c\uff0c\u5177\u6709<\/span>143,291<\/span>\u548c<\/span>284,706<\/span>\u4e2a<\/span>CpG<\/span>\u4f4d\u70b9\uff0c\u5e76\u8fdb\u884c\u4e86\u72ec\u7acb\u9884\u5904\u7406\u4ee5\u907f\u514d\u6cc4\u6f0f\u9884\u5904\u7406\u3002\u4e3b\u6210\u5206\u5206\u6790\u663e\u793a\u4e3b\u8981\u7ec6\u80de\u7c7b\u578b\u4e4b\u95f4\u5b58\u5728\u5206\u79bb\uff0c\u800c\u5bc6\u5207\u76f8\u5173\u7684\u7ec6\u80de\u5219\u9700\u8981\u9644\u52a0<\/span>PC<\/span>\u8fdb\u884c\u533a\u5206\uff08\u56fe<\/span>1 B-C<\/span>\uff09\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100009361\" data-ratio=\"0.9536423841059603\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_STxc3JHxvMqSpprDMTZA3h0aY9llQQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQc8jOdnNxFINl30EGmRvfxvU6gFlicUTYwzoj4edF8NG1EMSTxc3JHxvMqSpprDMTZA3h0aY9llQQ\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"755\" style=\"\" \/><\/p>\n\u56fe<\/span>1 CimpleG\u6846\u67b6<\/span><\/span><o:p><\/o:p><\/span><\/p>\n2. <\/span><\/strong>\u7ec6\u80de\u7c7b\u578b\u9884\u6d4b\u95ee\u9898\u7684\u57fa\u51c6\u6d4b\u8bd5<\/span><\/strong><o:p><\/o:p><\/span><\/strong><\/p>\nCimpleG\u4e0e\u5176\u4ed6\u751f\u6210\u8868\u89c2\u9057\u4f20\u7279\u5f81\u7684\u65b9\u6cd5\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u5305\u62ec\u51b3\u7b56\u6811\u3001\u968f\u673a\u68ee\u6797\u3001\u63d0\u5347\u6811\u3001\u795e\u7ecf\u7f51\u7edc\u548c\u5f39\u6027\u7f51\u7edc\u3002\u4e00\u4e9b\u6a21\u578b\u7531\u4e8e\u9ad8\u7ef4\u7279\u5f81\u5927\u5c0f\u800c\u65e0\u6cd5\u5e94\u5bf9\u6570\u636e\u96c6\uff0c\u56e0\u6b64\u6267\u884c\u4e86\u65e0\u76d1\u7763\u7279\u5f81\u9009\u62e9\u4f5c\u4e3a\u9884\u8bad\u7ec3\u6b65\u9aa4\u3002\u901a\u8fc7\u4ea4\u53c9\u9a8c\u8bc1\u6846\u67b6\u4f18\u5316\u4e86\u6240\u6709\u65b9\u6cd5\u7684\u53c2\u6570\uff0c\u5e76\u8bc4\u4f30\u4e86\u5206\u7c7b\u6027\u80fd\u3001\u8ba1\u7b97\u65f6\u95f4\u548c\u6bcf\u4e2a\u6a21\u578b\u4f7f\u7528\u7684\u7279\u5f81\u6570\u91cf\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n\u5728\u4f53\u7ec6\u80de\u548c\u767d\u7ec6\u80de\u6570\u636e\u96c6\u4e0a\uff0c<\/span>Elastic Net\u3001<\/span>CimpleG<\/span>\u548c<\/span>CimpleG<\/span>\uff08\u5206\u6570\uff09\u5177\u6709\u6700\u9ad8\u7684\u4e2d\u503c<\/span>AUPR<\/span>\uff08\u56fe <\/span>2 A-B<\/span>\uff09\uff0c\u8868\u660e\u8fd9\u4e9b\u662f\u6027\u80fd\u6700\u597d\u7684\u6a21\u578b\u3002\u8fd9\u4e9b\u65b9\u6cd5\u5728\u6b63\u6837\u672c\u6570\u91cf\u4e0a\u5177\u6709\u7a33\u5b9a\u7684<\/span>AUPR<\/span>\u503c\uff0c\u8868\u660e\u5b83\u4eec\u5bf9\u4e8e\u5c11\u91cf\u6b63\u6837\u672c\u800c\u8a00\u5177\u6709\u7a33\u5065\u6027\u3002\u5173\u4e8e\u8ba1\u7b97\u65f6\u95f4\uff0c<\/span>CimpleG<\/span>\u5e73\u5747\u9700\u8981<\/span>55.3<\/span>\u79d2\uff0c<\/span>Elastic Net<\/span>\u5e73\u5747\u9700\u8981<\/span>37.6<\/span>\u5206\u949f\uff0c\u800c\u66b4\u529b\u7b97\u6cd5\u5e73\u5747\u9700\u8981<\/span>6.61<\/span>\u5c0f\u65f6\u6765\u751f\u6210\u7b7e\u540d\uff08\u56fe <\/span>2<\/span><\/span> <\/span>C-D\uff09\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u8fd9\u4e09\u79cd\u65b9\u6cd5\u5728\u57fa\u4e8e<\/span>DNAm<\/span>\u7684\u7ec6\u80de\u5206\u7c7b\u95ee\u9898\u4e2d\u8868\u73b0\u540c\u6837\u51fa\u8272\uff0c\u800c<\/span>CimpleG<\/span>\u4e3a\u7279\u5f81\u9009\u62e9\u95ee\u9898\u63d0\u4f9b\u4e86\u663e\u7740\u7684\u52a0\u901f\u3002<\/span><\/span>\uff08<\/span>ps\uff1a<\/span><\/span>\u4e0d\u4f1a\u4f5c\u56fe\u600e\u4e48\u529e\uff1f\u53ef\u4ee5\u4f7f\u7528<\/span>\u6211\u4eec\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u5b9e\u73b0\uff0c\u4e91\u751f\u4fe1\u5206\u6790\u5de5\u5177\u5e73\u53f0\u5305\u542b\u8d85\u591a\u96f6\u4ee3\u7801\u5206\u6790\u548c\u7ed8\u56fe\u5c0f\u5de5\u5177\uff0c\u4e0a\u4f20\u6570\u636e\u4e00\u952e\u51fa\u56fe\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u6765\u5c1d\u8bd5\u54df\uff0c\u7f51\u5740\uff1a<\/span>http:\/\/www.biocloudservice.com\/home.html\uff09\u3002<\/span><\/span><\/span><\/strong><o:p><\/o:p><\/span><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100009362\" data-ratio=\"0.9195402298850575\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_vGSaUxpzcXrla3OqRodjyOZfpMh8Rg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQc8jOdnNxFINl30EGmRvfxtQJTmuQRVz7iafTnjDKa05Bib8vGSaUxpzcXrla3OqRodjyOZfpMh8Rg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"783\" style=\"\" \/><\/p>\n\u56fe<\/span>2 <\/span>\u7ec6\u80de\u7c7b\u578b\u9884\u6d4b\u95ee\u9898\u7684\u57fa\u51c6\u6d4b\u8bd5<\/span><o:p><\/o:p><\/span><\/p>\n3. DNA\u7532\u57fa\u5316\u4f4d\u70b9\u7684\u9009\u62e9<\/span><\/span><\/strong><o:p><\/o:p><\/span><\/strong><\/p>\nElastic Net\u9009\u62e9\u4e86\u6700\u5927\u6570\u91cf\u7684\u7279\u5f81\uff0c\u5176\u4e2d\u767d\u7ec6\u80de\u7684\u6240\u6709\u516d\u4e2a\u6a21\u578b\u4e2d\u6709<\/span>3378<\/span>\u4e2a\u72ec\u7279\u7279\u5f81\uff08\u56fe<\/span>3A<\/span>\uff09\uff0c\u4f53\u7ec6\u80de\u7684\u6240\u6709\u5341\u4e2a\u6a21\u578b\u4e2d\u6709<\/span>2345<\/span>\u4e2a\u72ec\u7279\u7279\u5f81\u3002\u5355\u7279\u5f81\u5206\u7c7b\u5668\uff08<\/span>CimpleG<\/span>\u548c<\/span>Brute force<\/span>\uff09\u4e3a\u4f53\u7ec6\u80de\u548c\u767d\u7ec6\u80de\u6570\u636e\u9009\u62e9\u4e86\u603b\u5171<\/span>10<\/span>\u4e2a\u548c<\/span>6<\/span>\u4e2a<\/span>DNAm<\/span>\u4f4d\u70b9\u3002<\/span>CimpleG<\/span>\u9009\u62e9\u7684\u6240\u6709<\/span>16<\/span>\u4e2a<\/span>DNAm<\/span>\u4e5f\u662f<\/span>Elastic Net<\/span>\u9009\u62e9\u7684<\/span>DNAm<\/span>\u4f4d\u70b9\u7684\u4e00\u90e8\u5206\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n\u89c2\u5bdf<\/span>CimpleG\u751f\u6210\u7684\u7279\u5b9a\u7279\u5f81\u4e5f\u5f88\u6709\u8da3\uff08\u56fe<\/span>3B-G<\/span>\uff09\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u57fa\u56e0\u7ec4\u4f4d\u7f6e\u53ef\u4ee5\u63d0\u4f9b\u5bf9\u7ec6\u80de\u672c\u8eab\u7684\u751f\u7269\u5b66\u6d1e\u5bdf\u3002\u4f8b\u5982\uff0c\u9009\u62e9\u9760\u8fd1<\/span>CD4<\/span>\uff08<\/span>cg05044173<\/span>\uff0c\u56fe<\/span>3C<\/span>\uff09\u548c<\/span>CD8<\/span>\uff08<\/span>cg04329870<\/span>\uff0c\u56fe<\/span>3D<\/span>\uff09\u57fa\u56e0\u7684<\/span>DNAm<\/span>\u4f4d\u70b9\u4f5c\u4e3a<\/span>CD4+<\/span>\u548c<\/span>CD8+T<\/span>\u7ec6\u80de\u7684\u6807\u8bb0\uff0c\u4ee5\u53ca\u9009\u62e9\u4f53\u5185\u7684<\/span>LIPE<\/span>\uff08\u8102\u80aa\u9176<\/span>E<\/span>\uff0c\u6fc0\u7d20\u654f\u611f\u578b\uff09\u4f5c\u4e3a\u8102\u80aa\u7ec6\u80de\u7684\u6807\u8bb0\u7269\u7684<\/span>DNAm<\/span>\u7ad9\u70b9\uff08<\/span>cg01537765<\/span>\uff09\u3002\u8fd8\u9009\u62e9\u4e86\u4e0a\u76ae\u95f4\u8d28\u8f6c\u5316\u76f8\u5173\u8f6c\u5f55\u56e0\u5b50<\/span>TWIST1<\/span>\u542f\u52a8\u5b50\u4e2d\u7684<\/span>CpG<\/span>\uff08<\/span>cg10624122<\/span>\uff09<\/span><\/span>\u4f5c\u4e3a\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u6807\u8bb0\uff0c\u4ee5\u53ca\u5176\u4ed6\u4e0e\u5177\u6709\u7ec6\u80de\u7279\u5f02\u6027\u8868\u8fbe\u6a21\u5f0f\u7684\u57fa\u56e0\u63a5\u8fd1\u7684<\/span>CpG\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n\u6700\u540e\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u767d\u7ec6\u80de\u6570\u636e\u4e2d\u4f7f\u7528\u7684\u4e00\u4e9b\u6837\u672c\u6765\u81ea\u8110\u5e26\u8840\u6216\u975e\u5065\u5eb7\u6837\u672c\uff0c\u4f46\u5728\u5206\u6790\u4e2d\uff0c\u6ca1\u6709\u4efb\u4f55\u534f\u53d8\u91cf\u4f1a\u5f71\u54cd<\/span>CimpleG\u5bfc\u51fa\u7684\u7b7e\u540d\u7684<\/span>DNAm<\/span>\u503c\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100009363\" data-ratio=\"0.7236180904522613\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_J1BBv0R0RXxLsZqMbOHibnZctGnpTA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQc8jOdnNxFINl30EGmRvfxsQZJiaFjgJbj8RqL3YxMiafp5ZFJ1BBv0R0RXxLsZqMbOHibnZctGnpTA\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"995\" style=\"\" \/><\/p>\n\u56fe<\/span>3<\/span> <\/span>DNA\u7532\u57fa\u5316\u4f4d\u70b9\u7684\u9009\u62e9<\/span><\/span><o:p><\/o:p><\/span><\/p>\n4. <\/span><\/strong>\u7ec6\u80de\u7c7b\u578b\u53cd\u5377\u79ef\u95ee\u9898\u7684\u57fa\u51c6\u6d4b\u8bd5<\/span><\/strong><o:p><\/o:p><\/span><\/strong><\/p>\n\u6211\u4eec\u8bc4\u4f30\u4e86\u767d\u7ec6\u80de\u4e2d\u7ec6\u80de\u53cd\u5377\u79ef\u95ee\u9898\u7684<\/span>DNAm\u7279\u5f81\u548c\u6a21\u578b\u9884\u6d4b\uff0c\u4f7f\u7528\u4e86\u4e0d\u540c\u7684\u65b9\u6cd5\u548c\u7b97\u6cd5\u3002\u5728\u8003\u8651\u4e3b\u8981\u767d\u7ec6\u80de\u7684\u53cd\u5377\u79ef\u95ee\u9898\u65f6\uff0c<\/span>IDOL<\/span>\u5177\u6709\u6700\u9ad8\u6392\u540d\uff0c\u5176\u6b21\u662f\u5177\u6709<\/span>10<\/span>\u4e2a<\/span>CpG<\/span>\u7684<\/span>CimpleG<\/span>\u548c<\/span>minfi<\/span>\uff08\u56fe<\/span>4<\/span>\uff09\u3002\u5728\u57fa\u4e8e\u5c0f\u7b7e\u540d\u7684\u65b9\u6cd5\u4e2d\uff0c<\/span>CimpleG<\/span>\u7684<\/span>RMSE<\/span>\u901a\u5e38\u4f4e\u4e8e\u7ade\u4e89\u65b9\u6cd5\u3002\u6211\u4eec\u8fd8\u5728\u4e24\u4e2a\u4eba\u5de5\u6df7\u5408\u6570\u636e\u96c6\u4e0a\u8bc4\u4f30\u4e86\u4e00\u7cfb\u5217\u65b9\u6cd5\uff0c\u5176\u4e2d<\/span>IDOL<\/span>\u83b7\u5f97\u4e86\u6700\u4f4e\u7684<\/span>RMSE<\/span>\uff0c\u5176\u6b21\u662f\u5177\u6709<\/span>10<\/span>\u4e2a<\/span>CpG<\/span>\u7684<\/span>CimpleG<\/span>\uff0c\u6bcf\u79cd\u7ec6\u80de\u7c7b\u578b\u5177\u6709\u5355\u4e2a<\/span>CpG<\/span>\u7684<\/span>CimpleG<\/span>\u83b7\u5f97\u4e86\u6700\u4f4e\u7684\u5e73\u5747<\/span>RMSE<\/span>\u3002<\/span>CimpleG<\/span>\u4ec5\u9700\u8981<\/span>12<\/span>\u4e2a\u4f4d\u70b9\uff0c\u800c\u5176\u4ed6\u65b9\u6cd5\u9700\u8981\u66f4\u591a\u7684<\/span>DNAm<\/span>\u4f4d\u70b9\u3002<\/span>CimpleG<\/span>\u6240\u9700\u7684<\/span>DNAm<\/span>\u4f4d\u70b9\u6bd4\u6027\u80fd\u6700\u4f73\u7684\u65b9\u6cd5<\/span>IDOL<\/span>\u3001<\/span>CimpleG.10<\/span>\u548c<\/span>minfi<\/span>\u81f3\u5c11\u5c11<\/span>10<\/span>\u500d\u3002\u603b\u7684\u6765\u8bf4\uff0c<\/span>CimpleG<\/span>\u662f\u4e00\u79cd\u6709\u7ade\u4e89\u529b\u7684\u7ec6\u80de\u53cd\u5377\u79ef\u65b9\u6cd5\uff0c\u540c\u65f6\u4e5f\u662f\u5c0f\u7279\u5f81\u7684\u6700\u4f73\u6267\u884c\u65b9\u6cd5\u3002<\/span><\/span><o:p><\/o:p><\/span><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100009364\" data-ratio=\"1.1388888888888888\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_oicSibgPP8lbvYAuuCeB558fMFsbZQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQc8jOdnNxFINl30EGmRvfx7ZuG0UVc2iaPkhZSOluwFdJZ8GOoicSibgPP8lbvYAuuCeB558fMFsbZQ\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"720\" style=\"\" \/><\/p>\n\u56fe<\/span>4 <\/span>\u7ec6\u80de\u7c7b\u578b\u53cd\u5377\u79ef\u95ee\u9898\u7684\u57fa\u51c6\u6d4b\u8bd5<\/span><o:p><\/o:p><\/span><\/p>\n\u6587\u7ae0\u5c0f\u7ed3<\/span><\/strong><\/span><o:p><\/o:p><\/span><\/strong><\/p>\n\u8fd9\u7bc7\u6587\u7ae0\u4ece\u7532\u57fa\u5316\u89d2\u5ea6\u51fa\u53d1\uff0c\u6784\u5efa\u4e86<\/span>CimpleG\u7684\u8ba1\u7b97\u6846\u67b6\uff0c\u7528\u4e8e\u68c0\u6d4b\u5c0f\u578b<\/span>CpG<\/span>\u7532\u57fa\u5316\u7279\u5f81\uff0c\u7279\u522b\u662f\u5728\u7ec6\u80de\u7c7b\u578b\u5206\u7c7b\u548c\u7ec6\u80de\u6df7\u5408\u7269\u53cd\u5377\u79ef\u65b9\u9762\u3002<\/span>CimpleG<\/span><\/span>\u662f<\/span>\u4e00\u79cd\u65b0\u9896\u7684\u65b9\u6cd5\uff0c\u901a\u8fc7\u5c06<\/span>t\u7edf\u8ba1\u91cf\u4e0e\u7cbe\u786e\u53ec\u56de\u66f2\u7ebf\u4e0b\u9762\u79ef\uff08<\/span>AUPR<\/span>\uff09\u76f8\u7ed3\u5408\uff0c\u4f7f\u7528\u5355\u53d8\u91cf\u7279\u5f81\u9009\u62e9\u6765\u9009\u62e9\u7528\u4e8e\u7ec6\u80de\u7c7b\u578b\u5206\u7c7b\u7684\u6700\u4f73<\/span>DNAm<\/span>\u4f4d\u70b9\u3002\u4e0e\u73b0\u6709\u7684<\/span>IDOL<\/span>\u548c<\/span>EpiDISH<\/span>\u65b9\u6cd5\u76f8\u6bd4\uff0c<\/span>CimpleG<\/span>\u5728\u6267\u884c\u65f6\u95f4\u548c\u51c6\u786e\u6027\u65b9\u9762\u8868\u73b0\u51fa\u8272\u3002\u6b64\u5916\uff0c<\/span>CimpleG<\/span>\u7684\u7075\u6d3b\u6027\u548c\u6548\u7387\u4f7f\u5176\u9002\u7528\u4e8e\u9700\u8981\u5feb\u901f\u3001\u6807\u51c6\u5316\u548c\u7ecf\u6d4e\u9ad8\u6548\u5206\u6790\u7684\u4e34\u5e8a\u73af\u5883\u3002\u603b\u7684\u6765\u8bf4\uff0c<\/span>CimpleG<\/span>\u7684\u521b\u65b0\u6027\u5728<\/span><\/span>\u4e8e\u5176\u72ec\u7279\u7684\u8ba1\u7b97\u65b9\u6cd5\u548c\u5e7f\u6cdb\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u4e3a\u5bfb\u627e\u548c\u5229\u7528<\/span>CpG\u7532\u57fa\u5316\u7b7e\u540d\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u548c\u5de5\u5177\u3002<\/span><\/span>\u679c\u7136\u7a81\u7834\u751f\u4fe1\u5185\u5377\u7684\u529e\u6cd5\u5c31\u662f\u4ece\u7b97\u6cd5\u51fa\u53d1\uff0c\u4f5c\u8005\u7684\u4ee3\u7801\u548c\u7b97\u6cd5\u529f\u529b\u624e\u5b9e\uff0c\u8fd8\u4ece\u5c11\u6709\u4eba\u6d89\u53ca\u7684\u7532\u57fa\u5316\u51fa\u53d1\uff0c\u80fd\u53d1<\/span>1<\/span><\/span>2<\/span>\u5206<\/span>+<\/span>\u7684\u6587\u7ae0\u53ef\u8c13\u662f\u5b9e\u81f3\u540d\u5f52\u3002\u5728\u8fd9\u4e9b\u7b97\u6cd5\u7684\u57fa\u7840\u4e0a\u52a0\u4ee5\u6539\u8fdb\uff0c\u6587\u7ae0\u7684\u521b\u65b0\u6027\u5f88\u9ad8\uff0c\u9ad8\u5206\u671f\u520a\u7684\u8ba4\u53ef\u5ea6\u4e5f\u9ad8\u3002\u5728\u7b97\u6cd5\u4e0a\u6709\u4e00\u4e9b\u57fa\u7840\u7684\u5c0f\u4f19\u4f34\u4eec\u8d76\u7d27\u5b66\u8d77\u6765\u5427\uff01<\/span><\/span>\uff08\u5982\u679c\u4f60\u8fd8\u4e0d\u77e5\u9053\u5982\u4f55\u5c06\u6539\u8fdb\u7b97\u6cd5\uff0c\u6216\u8005\u6ca1\u6709\u601d\u8def\uff0c\u5c31\u8d76\u7d27\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\u6765\u54a8\u8be2\u5c0f\u9014\u5427\uff01\uff09<\/span><\/strong><\/span><\/p>\n\u5c0f\u679c\u8fd8\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n <\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017027\" data-ratio=\"1\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-38.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'&from=appmsg\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n <\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017028\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_7TvAyUibd1TPhJmZfialJtv6tu2SEg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100017029\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_9N02aBaau07RufXeXRLmvAHsrFZxtw.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;text-wrap: wrap;\" \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" 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