{"id":54368,"date":"2024-06-16T14:10:28","date_gmt":"2024-06-16T06:10:28","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=54368"},"modified":"2024-06-16T14:10:28","modified_gmt":"2024-06-16T06:10:28","slug":"%e4%b8%8d%e6%98%af%e6%b5%8b%e5%ba%8f%e5%81%9a%e4%b8%8d%e8%b5%b7%ef%bc%8c%e8%80%8c%e6%98%af%e6%95%b0%e6%8d%ae%e6%8c%96%e6%8e%98%e6%9b%b4%e6%9c%89%e6%80%a7%e4%bb%b7%e6%af%94%ef%bc%81%e4%b8%8a%e6%b5%b7","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=54368","title":{"rendered":"\u4e0d\u662f\u6d4b\u5e8f\u505a\u4e0d\u8d77\uff0c\u800c\u662f\u6570\u636e\u6316\u6398\u66f4\u6709\u6027\u4ef7\u6bd4\uff01\u4e0a\u6d77\u4ea4\u5927\u7b2c\u4e5d\u4eba\u6c11\u533b\u96626\u5206+\u975e\u80bf\u7624\u7eaf\u751f\u4fe1\uff0cm7G\u57fa\u56e0+\u514d\u75ab\u666f\u89c2\u5206\u6790\uff0c\u4e34\u5e8a\u4ef7\u503c\u7ffb\u500d\uff01"},"content":{"rendered":"


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href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzk0MDQ2MTU0Mg==&mid=2247492498&idx=1&sn=e1f2711d5477846eb24814105f3d3993\" target=\"_blank\" title=\"\u9605\u8bfb\u539f\u6587\" rel=\"noopener\">http:\/\/mp.weixin.qq.com\/s?__biz=Mzk0MDQ2MTU0Mg==&mid=2247492498&idx=1&sn=e1f2711d5477846eb24814105f3d3993<\/a><\/p>\n<\/div>\n<p style=\"text-align: center;\" data-mpa-powered-by=\"yiban.io\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100015224\" data-ratio=\"0.2222222222222222\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_r0Gd7iaumIGMiaia97aHFV15nrpdzw-94.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxQW8Zek7Noib2uBhB3ZE3yMxI2Hfic7cGTdPYiacicg47jficdr5BVr0Gd7iaumIGMiaia97aHFV15nrpdzw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"900\" style=\"\" \/><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u4eca\u5929\u5c0f\u9014\u5728PubMed\u53d1\u73b0\u4e00\u7bc7\u601d\u8def\u7b80\u5355\uff0c\u4f46\u662f\u5f71\u54cd\u56e0\u5b50\u4e0d\u7b80\u5355\u7684SCI\uff0c\u662f\u5565SCI\uff0c\u7eaf\u751f\u4fe1\u8fd8\u80fd\u53d1\u63a5\u8fd17\u5206\uff08IF:6.986\uff09SCI\uff0c\u8fd9\u4e00\u4e0b\u5b50\u5c31\u6fc0\u8d77\u672c\u5c0f\u9014\u7684\u597d\u5947\u5fc3\uff0c\u90a3\u5c0f\u9014\u8fd8\u4e0d\u5f97\u8d76\u7d27\u7ed9\u5404\u4f4d\u79d1\u7814\u5927\u4f6c\u732e\u4e0a\uff01<\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u8fd1\u51e0\u5e74\uff0cRNA\u4fee\u9970\u4e5f\u662f\u6bd4\u8f83\u706b\u70ed\u70b9\uff0c\u5927\u5bb6\u76ee\u524d\u91cd\u70b9\u5173\u6ce8\u7684\u662fm6A\u4fee\u9970\uff0c\u5176\u6b21\u50cfm1A\u548cm6A\u7b49\uff0c\u800cm7G\uff0c\u5219\u662fRNA\u4fee\u9970\u91cc\u7684\u540e\u8d77\u4e4b\u79c0\u3002m7G\u4f5c\u4e3a\u4e00\u79cd\u91cd\u8981\u7684\u8868\u89c2\u9057\u4f20\u4fee\u9970\uff0cm7G 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Research<\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=6.986<\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e741\u6708<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\"><span style=\"font-size: 16px;color: rgb(0, 82, 255);\"><\/span><\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 18px;\"><strong><span style=\"font-size: 18px;color: rgb(0, 82, 255);\">\u7814\u7a76\u80cc\u666f<\/span><\/strong><\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u590d\u53d1\u6027\u963f\u5f17\u4ed6\u53e3\u708e(Recurrent aphthous stomatitis, RAS)\u662f\u53e3\u8154\u9ecf\u819c\u6700\u5e38\u89c1\u7684\u708e\u75c7\u6027\u75be\u75c5\uff0c\u53ef\u5f71\u54cd\u6613\u611f\u4eba\u7fa4\u7684\u751f\u6d3b\u8d28\u91cf\uff0c\u751a\u81f3\u5bfc\u81f4\u80bf\u7624\u7684\u53d1\u751f\u3002N7-\u7532\u57fa\u9e1f\u560c\u5464(m7G)\u5728\u591a\u79cd\u7ec6\u80de\u6d3b\u52a8\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u4f46\u5c1a\u672a\u5728RAS\u4e2d\u88ab\u7814\u7a76\u3002<\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 18px;color: rgb(0, 82, 255);\"><strong>\u6570\u636e\u6765\u6e90<\/strong><\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100008800\" data-ratio=\"0.15813953488372093\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_cbCTaDlicgACvmQ4ibSOuH1RSSTFUw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRWB4dQm1OZegGxrUCJnTpibticA03gg9m7CVCChMQxumZ3SNJFcbCTaDlicgACvmQ4ibSOuH1RSSTFUw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"860\" style=\"\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 18px;\"><strong><span style=\"font-size: 18px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;color: rgb(0, 82, 255);\">\u7814\u7a76\u601d\u8def<\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u4eceGEO\u6570\u636e\u5e93\u83b7\u5f97\u6570\u636e\u96c6\uff0c\u7b5b\u9009\u4e86m7G\u76f8\u5173\u7684\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\uff08DEG\uff09\uff0c\u5206\u6790\u83b7\u5f97\u4e8611\u4e2am7G\u76f8\u5173\u7684DEGs\u3002\u5e76\u7814\u7a76\u4e86\u5168\u9762\u7684\u514d\u75ab\u6d78\u6da6\u56fe\u8c31\uff0c\u8fd9\u8868\u660e\u51e0\u79cd\u514d\u75ab\u6807\u5fd7\u7269\u662f\u53ef\u80fd\u7684\u514d\u75ab\u6cbb\u7597\u9776\u70b9\u3002\u5e76\u7814\u7a76\u4e86m7G\u76f8\u5173DEG\u4e0e\u514d\u75ab\u7ec6\u80de\/\u9014\u5f84\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002\u968f\u540e\u8fdb\u884c\u4e86\u529f\u80fd\u5bcc\u96c6\u5206\u6790\uff0c\u5e76\u6784\u5efa\u4e86RAS\u4e2d\u7684\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff08PPI\uff09\u548c\u591a\u56e0\u5b50\u8c03\u63a7\u7f51\u7edc\u3002\u63d0\u53d6m7G\u76f8\u5173\u67a2\u7ebd\u57fa\u56e0\uff0c\u5f62\u6210\u76f8\u5e94\u7684m7G\u9884\u6d4b\u7279\u5f81\uff0c\u9274\u5b9a4\u4e2a\u67a2\u7ebd\u57fa\u56e0\uff08DDX58\u3001IFI27\u3001IFIT5\u548cPML\uff09\uff0c\u9a8c\u8bc1\u76f8\u5e94\u7684m7G\u9884\u6d4b\u6027\u7279\u5f81\u3002<\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"color: rgb(0, 82, 255);font-size: 18px;\"><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);\">1.m7G\u76f8\u5173DEGs\u7684\u9274\u5b9a\u4ee5\u53ca\u514d\u75ab\u6d78\u6da6\u5206\u6790<\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u901a\u8fc7\u5bf9\u6570\u636e\u96c6GSE37265\u7684\u5dee\u5f02\u5206\u6790\uff0c\u5171\u9274\u5b9a\u51fa11\u4e2am7G\u76f8\u5173\u7684DEGs\uff0c\u5176\u4e2d9\u4e2a\u5728RAS\u76f8\u5bf9\u4e8e\u6b63\u5e38\u6837\u672c\u4e2d\u4e0a\u8c03(CMTR1, CYFIP2, DDX58, IFI27, IFIT5, NT5C3A, PML, PRKCB, RPS6KA1)\uff0c 2\u4e2a\u4e0b\u8c03(MKNK2\u548cEIF4EBP1)(\u88681)\u3002\u901a\u8fc7\u706b\u5c71\u56fe\u6765\u53ef\u89c6\u5316m7G\u76f8\u5173\u57fa\u56e0\u7684\u8868\u8fbe(\u56fe1A)\u3002\u6b64\u5916\uff0c 11\u4e2am7G\u76f8\u5173\u7684DEGs\u5728\u4e0d\u540c\u6837\u672c\u4e2d\u7684\u8868\u8fbe\u6a21\u5f0f\u88ab\u805a\u7c7b\u6210\u70ed\u56fe(\u56fe1B)\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100008801\" data-ratio=\"0.4425925925925926\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_7iaFicaT2BllFMYSuqIKv3eqkKfM2Q.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRWB4dQm1OZegGxrUCJnTpibVZf6BibfdibzDWSs70HpS8UAVXO37iaFicaT2BllFMYSuqIKv3eqkKfM2Q\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"1080\" style=\"\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">\u56fe<\/span><span style=\"font-size: 14px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">1<\/span><span style=\"font-size: 14px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\"> <\/span><span style=\"font-size: 14px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">\u6570\u636e\u96c6<\/span><span style=\"font-size: 14px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">GSE37265<\/span><span style=\"font-size: 14px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">\u4e2d<\/span><span style=\"font-size: 14px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">m7G<\/span><span style=\"font-size: 14px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">\u76f8\u5173<\/span><span style=\"font-size: 14px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">DEGs<\/span><span style=\"font-size: 14px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">\u7684\u53ef\u89c6\u5316<\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: left;margin-bottom: 24px;\"><span style=\"background-color: rgb(61, 170, 214);font-size: 16px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;text-align: justify;color: rgb(255, 255, 255);\">2.\u514d\u75ab\u666f\u89c2\u5206\u6790<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u901a\u8fc7\u6784\u5efa\u4e86\u70ed\u56fe\u5168\u9762\u5c55\u793aRAS\u4e2d\u7684\u514d\u75ab\u666f\u89c2\uff0c\u63cf\u7ed8\u4e86RAS\u548c\u6b63\u5e38\u6837\u672c\u4e4b\u95f416\u79cd\u514d\u75ab\u7ec6\u80de\u7c7b\u578b\u548c13\u79cd\u514d\u75ab\u901a\u8def\u7684\u5bcc\u96c6\u8bc4\u5206(\u56fe2)\u3002\u5e76\u8fdb\u884c\u4e86RAS\u6837\u672c\u4e2d\u514d\u75ab\u7ec6\u80de\u5bcc\u96c6\u8bc4\u5206(\u56fe3A)\u548c\u514d\u75ab\u529f\u80fd\u5bcc\u96c6\u8bc4\u5206(\u56fe3B)\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u5206\u6790\u3002\u5728\u76f8\u5173\u77e9\u9635\u4e2d\uff0c\u89c2\u5bdf\u5230\u4e00\u4e9b\u7c7b\u578b\u7684\u514d\u75ab\u7ec6\u80de(\u5982CD8+ T\u7ec6\u80de\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u548cTreg\u7ec6\u80de)\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u5bc6\u5207\u6b63\u76f8\u5173\uff0c\u8868\u660e\u5b83\u4eec\u5728RAS\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u5904\u4e8e\u514d\u75ab\u6d3b\u52a8\u7684\u4e2d\u5fc3\u4f4d\u7f6e(\u56fe3A)\u3002\u6b64\u5916\uff0c\u591a\u79cd\u514d\u75ab\u53cd\u5e94\u5728RAS\u4e2d\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\uff0c\u5c24\u5176\u662f\u708e\u75c7\u4fc3\u8fdb\u3001\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\u3001T\u7ec6\u80de\u5171\u523a\u6fc0\u7b49\u4fe1\u53f7\u901a\u8def(\u56fe3B)\u3002\u8fdb\u4e00\u6b65\u8fdb\u884c\u4e86\u514d\u75ab\u7ec6\u80de\u901a\u8def\u7684\u5dee\u5f02\u5206\u6790(\u56fe4)\u3002\u7bb1\u5f62\u56fe\u663e\u793a\uff0cRAS\u7ec4\u4e2d\u9664\u80a5\u5927\u7ec6\u80de\u3001NK\u7ec6\u80de\u548cTh2\u7ec6\u80de\u5916\uff0c\u5176\u4ed6\u4e0d\u540c\u514d\u75ab\u7ec6\u80de\u7684\u6d78\u6da6\u663e\u8457\u589e\u5f3a(\u56fe4A)\u3002\u8fd8\u8fdb\u884c\u4e86Pearson\u76f8\u5173\u5206\u6790\uff0c\u4ee5\u5206\u6790\u7b5b\u9009\u7684m7g\u76f8\u5173\u7684DEGs\u548c\u4e0d\u540c\u7684\u514d\u75ab\u7ec6\u80de\/\u901a\u8def\u4e4b\u95f4\u7684\u5173\u8054\u3002\u53d1\u73b09\u4e2a\u57fa\u56e0(CMTR1\u3001CYFIP2\u3001DDX58\u3001IFI27\u3001IFIT5\u3001NT5C3A\u3001PML\u3001PRKCB\u548cRPS6KA1)\u4e0e\u514d\u75ab\u6d3b\u6027\u5bc6\u5207\u6b63\u76f8\u5173\uff0c\u800cMKNK2\u4e0e\u514d\u75ab\u6d3b\u6027\u5448\u8d1f\u76f8\u5173\u3002<strong><span style=\"font-size: 16px;color: rgb(0, 82, 255);\">\uff08ps\uff1a\u514d\u75ab\u6d78\u6da6\u5206\u6790\u3001\u5bcc\u96c6\u5206\u6790\u7b49\u591a\u79cd\u751f\u4fe1\u5206\u6790\u53ef\u4ee5\u7528\u5c0f\u9014\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u5b9e\u73b0\uff0c\u4e91\u751f\u4fe1\u5206\u6790\u5de5\u5177\u5e73\u53f0\u5305\u542b\u8d85\u591a\u96f6\u4ee3\u7801\u5206\u6790\u548c\u7ed8\u56fe\u5c0f\u5de5\u5177\uff0c\u4e0a\u4f20\u6570\u636e\u4e00\u952e\u51fa\u56fe\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u6765\u5c1d\u8bd5\u54df\uff0c\u7f51\u5740\uff1a<\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\"><strong><span style=\"font-size: 16px;color: rgb(0, 82, 255);\">http:\/\/www.biocloudservice.com\/home.html\uff09\u3002<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100008802\" data-ratio=\"0.7086614173228346\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_t7Q20LnRyibCAjfxNDrIb50Ze8GdWQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRWB4dQm1OZegGxrUCJnTpibxWunfia9R6VnZBUY5Y2zQ21Ew6t7Q20LnRyibCAjfxNDrIb50Ze8GdWQ\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"1016\" style=\"\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">\u56fe2 RAS\u548c\u6b63\u5e38\u6837\u54c1\u4e4b\u95f4\u768416\u79cd\u514d\u75ab\u7ec6\u80de\u7c7b\u578b\u548c13\u79cd\u514d\u75ab\u9014\u5f84\u7684\u70ed\u56fe\u53ef\u89c6\u5316<\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100008803\" data-ratio=\"0.876979293544458\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_HEEJzgKOgUeSu0o2wt9le8KpQTibUQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRWB4dQm1OZegGxrUCJnTpib39sEPviaib3tuyYk7suIvjvY3iaEHEEJzgKOgUeSu0o2wt9le8KpQTibUQ\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"821\" style=\"\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;\">\u56fe3 RAS\u7684\u514d\u75ab\u6d78\u6da6<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100008804\" data-ratio=\"0.46574074074074073\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_iaK9gyc7fYhb1MictQavy7eFnb9oPA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRWB4dQm1OZegGxrUCJnTpib5jic78al6vnUP5DzupZzaLKarvQiaK9gyc7fYhb1MictQavy7eFnb9oPA\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"1080\" style=\"\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;text-align: justify;\">\u56fe4 11\u79cdm7G\u76f8\u5173DEGs\u4e0e16\u79cd\u514d\u75ab\u7ec6\u80de\u7c7b\u578b\u548c13\u79cd\u514d\u75ab\u9014\u5f84\u4e4b\u95f4\u7684\u76f8\u5173\u6027<\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"background-color: rgb(61, 170, 214);font-size: 16px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;color: rgb(255, 255, 255);\">3.\u529f\u80fd\u5bcc\u96c6\u5206\u6790<\/span><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u63a5\u4e0b\u6765\uff0c\u91c7\u7528GO\u548cKEGG\u5bcc\u96c6\u5206\u6790\u63a2\u7a7610\u4e2a\u514d\u75ab\u76f8\u5173m7G-DEGs\u7684\u5206\u5b50\u529f\u80fd\u548c\u901a\u8def\u3002DEGs\u7684BP\u4e3b\u8981\u53c2\u4e0e\u5bf9\u75c5\u6bd2\u7684\u9632\u5fa1\u53cd\u5e94\u3001\u51cb\u4ea1\u8fc7\u7a0b\u3001\u56fa\u6709\u514d\u75ab\u53cd\u5e94\u3001\u80bd\u57fa\u4e1d\u6c28\u9178\u78f7\u9178\u5316\u4ee5\u53ca\u5bbf\u4e3b\u5bf9\u75c5\u6bd2\u9632\u5fa1\u53cd\u5e94\u7684\u6b63\u5411\u8c03\u8282(\u56fe5A)\u3002\u53d1\u73b0\u8fd9\u4e9bDEGs\u663e\u8457\u5bcc\u96c6\u4e8e\u7ec6\u80de\u8d28\u3001\u7ec6\u80de\u8d28\u3001\u76b1\u8936\u819c\u3001PML\u5c0f\u4f53\u548c\u6838\u8d28(\u56fe5B)\u3002MF\u4e2d\u4e3b\u8981\u53c2\u4e0e\u86cb\u767d\u6fc0\u9176\u6d3b\u6027\u3001\u86cb\u767d\u4e1d\u6c28\u9178\/\u82cf\u6c28\u9178\u6fc0\u9176\u6d3b\u6027\u3001\u86cb\u767d\u4e1d\u6c28\u9178\/\u82cf\u6c28\u9178\/\u916a\u6c28\u9178\u6fc0\u9176\u6d3b\u6027\u3001\u5355\u94feRNA\u7ed3\u5408\u3001ATP\u7ed3\u5408(\u56fe5C)\u3002\u6700\u91cd\u8981\u7684\u662f\uff0cKEGG\u5206\u6790\u663e\u793a\u8fd9\u4e9b\u4e0em7G\u76f8\u5173\u7684DEGs\u5728\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\u5bcc\u96c6:\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd21\u578b\u611f\u67d3\u3001mTOR\u4fe1\u53f7\u901a\u8def\u3001HIF-1\u4fe1\u53f7\u901a\u8def\u3001\u80f0\u5c9b\u7d20\u62b5\u6297\u3001NF – \u03ba B\u4fe1\u53f7\u901a\u8def\u548cMAPK\u4fe1\u53f7\u901a\u8def(\u56fe5D),\u6b64\u5916\uff0c\u4e3a\u4e86\u8fdb\u4e00\u6b65\u8bc6\u522bRAS\u6837\u672c\u4e2d\u7684\u4e3b\u8981\u4fe1\u53f7\u901a\u8def\uff0c\u4f7f\u7528GSEA\u65b9\u6cd5\u5bf9\u6574\u4e2a\u8f6c\u5f55\u7ec4\u6570\u636e\u8fdb\u884c\u4e86\u5bcc\u96c6\u5206\u6790\u3002\u5982\u56fe6A-F\u6240\u793a\uff0c\u8fd9\u4e9b\u57fa\u56e0\u4e0eT\u7ec6\u80de\u53d7\u4f53\u3001\u8d8b\u5316\u56e0\u5b50\u3001VEGF\u3001JAK-STAT\u3001\u8840\u5c0f\u677f\u5f62\u6001\u53d1\u751f\u3001\u7ec6\u80de\u8870\u8001\u8c03\u8282\u7b49\u4fe1\u53f7\u901a\u8def\u5f3a\u76f8\u5173\uff0c\u8fd9\u4e0eDEGs\u7684GO\u548cKEGG\u5206\u6790\u7ed3\u679c\u4e00\u81f4\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100008805\" data-ratio=\"0.8966376089663761\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_jpKSia9SyLMHXVg9oiblrUpsK2sWTQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRWB4dQm1OZegGxrUCJnTpibJ47YsnJvOPXgxTtKuadNJjmuhfjpKSia9SyLMHXVg9oiblrUpsK2sWTQ\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"803\" style=\"\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">\u56fe5 RAS\u7ec4\u548c\u6b63\u5e38\u7ec4\u4e4b\u95f410\u4e2a\u514d\u75ab\u76f8\u5173<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">m7G-DEGs\u7684\u5bcc\u96c6\u5206\u6790<\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100008806\" data-ratio=\"1.3555555555555556\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_8cBfpN8tsiczbYkibsbzRib6vDchRA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRWB4dQm1OZegGxrUCJnTpibO5kOibNPmOqcicBmWcb2Xx4chcBnJ8cBfpN8tsiczbYkibsbzRib6vDchRA\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"720\" style=\"\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;\">\u56fe6 \u57fa\u4e8eRAS\u548c\u6b63\u5e38\u7ec4\u4e4b\u95f4\u7684\u6574\u4e2a\u8f6c\u5f55\u7ec4\u6570\u636e\u7684<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;\">\u57fa\u56e0\u96c6\u5bcc\u96c6\u5206\u6790\uff08GSEA\uff09<\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);\">4.PPI\u7f51\u7edc\u548c\u591a\u56e0\u5b50\u8c03\u63a7\u7f51\u7edc\u7684\u6784\u5efa\u4ee5\u53cam7G\u76f8\u5173\u57fa\u56e0\u7684\u9a8c\u8bc1<\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u5229\u7528STRING\u6570\u636e\u5e93\u6784\u5efa10\u4e2a\u514d\u75ab\u76f8\u5173m7G-DEGs\u7684PPI\u7f51\u7edc\uff0c\u5e76\u5728Cytoscape\u8f6f\u4ef6\u4e2d\u8fdb\u884c\u53ef\u89c6\u5316\u3002CytoHubba\u9274\u5b9a\u5e76\u5c55\u793a\u4e864\u4e2a\u67a2\u7ebd\u57fa\u56e0\uff0c\u5305\u62ecDDX58\u3001IFI27\u3001IFIT5\u548cPML(\u56fe7B)\u3002\u5176\u4e2dDDX58\u4f4d\u4e8e\u6838\u5fc3\u57fa\u56e0\u7684\u4e2d\u5fc3\u4f4d\u7f6e\u3002\u8fd1\u5e74\u6765\uff0c\u5229\u7528\u5728\u7ebf\u6570\u636e\u5e93\u7814\u7a76\u4e86\u8fd94\u4e2a\u5173\u952e\u57fa\u56e0\u7684\u591a\u56e0\u5b50\u8c03\u63a7\u7f51\u7edc\u3002\u5982\u56fe7C\u6240\u793a\uff0cTFs – miRNAs – mrnas(\u67a2\u7ebd\u57fa\u56e0)\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u5305\u542b3\u4e2amiRNAs (hsa-miR-423-3p\u3001hsa-miR-10b-35p\u3001hsa-miR-218-5p)\u548c5\u4e2aTFs (APEX1\u3001SOX10\u3001JDP3\u3001AHR\u3001JDP2)\u3002<\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u5e76\u8fdb\u4e00\u6b65\u901a\u8fc7ROC\u66f2\u7ebf\u8bc4\u4f30m7G\u76f8\u5173\u7684\u5173\u952e\u57fa\u56e0\u80fd\u5426\u533a\u5206RAS\u60a3\u8005\u548c\u6b63\u5e38\u60a3\u8005\u3002\u5982\u56fe8A-D\u6240\u793a\uff0c\u7531DDX58, IFI27, IFIT5\u548cPML\u7ec4\u6210\u7684m7G\u57fa\u56e0\u7279\u5f81\u663e\u793a\u51fa\u5bf9RAS\u7684\u826f\u597d\u9884\u6d4b\u4ef7\u503c\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100008807\" data-ratio=\"0.8674698795180723\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_t4bPDMEm7qGsdaW8L0iaqFEzibfclg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRWB4dQm1OZegGxrUCJnTpibwVY2NqWFzibjOTx1jicutnOAGkgtt4bPDMEm7qGsdaW8L0iaqFEzibfclg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"830\" style=\"\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">\u56fe7 \u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff08PPI\uff09<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">\u548c\u591a\u56e0\u5b50\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc<\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100008808\" data-ratio=\"0.9690444145356663\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_scnRmiaTZYVyTMJrpZ3OfwDaYQWrHA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRWB4dQm1OZegGxrUCJnTpibR3oVWicaoTk4XZVME21dO4ltxEscnRmiaTZYVyTMJrpZ3OfwDaYQWrHA\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"743\" style=\"\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;\">\u56fe8 ROC\u66f2\u7ebf\u9a8c\u8bc14\u4e2a\u57fa\u56e0m7G\u7279\u5f81\u5bf9RAS\u7684\u9884\u6d4b\u4ef7\u503c<\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;background-color: rgb(61, 170, 214);color: rgb(255, 255, 255);\">5.\u5019\u9009\u836f\u7269\u7684\u9274\u5b9a\u548c\u75be\u75c5\u5173\u8054<\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u5c064\u4e2a\u67a2\u7ebd\u57fa\u56e0\u4e0a\u4f20\u5230Enrichr\u7684DSigDB\u7f51\u7ad9\uff0c\u786e\u5b9a\u4e86\u5bf9RAS\u53ef\u80fd\u5177\u6709\u7597\u6548\u7684\u524d10\u79cd\u6cbb\u7597\u6027\u5316\u5408\u7269\uff0c\u5e76\u6839\u636e\u5176\u7efc\u5408\u8bc4\u5206\u8fdb\u884c\u6392\u5e8f\uff0c\u5305\u62ec\u4e19\u6c2f\u62c9\u55ea\u3001\u8212\u6d1b\u5730\u5c14\u3001\u4e19\u6cca\u915a\u3001\u7279\u975e\u90a3\u5b9a\u30013 ‘ -\u53e0\u6c2e-3 ‘ 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style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100008809\" data-ratio=\"0.7531380753138075\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_9qWng0OdHcqdm0d7MC9MWCasP4yqQA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRWB4dQm1OZegGxrUCJnTpibJDfBM9Q0icQrnZKZ8yuzeyzOX9qWng0OdHcqdm0d7MC9MWCasP4yqQA\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"956\" style=\"\" \/><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.034em;\">\u56fe9 \u836f\u7269\u7279\u5f81\u6570\u636e\u5e93 \uff08DSigDB\uff09 \u4e2d 10 \u4e2a\u67a2\u7ebd\u57fa\u56e0\u7684\u524d 4 \u4e2a\u6f5c\u5728\u6cbb\u7597\u836f\u7269\u9776\u70b9<\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100008810\" data-ratio=\"2.471042471042471\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/14_0Bm3icKNcMGklXC1Nu5IOpzfMwv9Fw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRWB4dQm1OZegGxrUCJnTpibb1eKLlxRwSZml7FkSrW4HUUz00Bm3icKNcMGklXC1Nu5IOpzfMwv9Fw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"518\" style=\"\"><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"font-size: 14px;\">\u56fe10 \u4f7f\u7528\u6bd4\u8f83\u6bd2\u7406\u57fa\u56e0\u7ec4\u5b66\u6570\u636e\u5e93\uff08CTD\uff09\u8bc4\u4f304\u4e2a\u67a2\u7ebd\u57fa\u56e0\uff08DDX58\uff0cIFI27\uff0cIFIT5\u548cPML\uff09\u7684\u57fa\u56e0-\u75be\u75c5\u8054\u7cfb<\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: center;margin-bottom: 24px;\"><span style=\"color: rgb(0, 82, 255);font-size: 18px;\"><strong>\u6587\u7ae0\u5c0f\u7ed3<\/strong><\/span><o:p><\/o:p><\/p>\n<p style=\"margin-bottom: 24px;\"><span style=\"font-size: 16px;\">\u8fd9\u4e2a\u6587\u7ae0\u6700\u5927\u7684\u4eae\u70b9\u662f\u6293\u4f4f\u70ed\u70b9\uff0c\u521b\u65b0\u70b9\u5728\u4e8e\u9996\u6b21\u8bc1\u660e\u4e86m7G\u5728RAS\u53d1\u751f\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u7684\u5b58\u5728\uff0c m7G\u4e0e\u514d\u75ab\u666f\u89c2\u5206\u6790\u8fdb\u884c\u7ed3\u5408\uff0c\u4e0d\u5c40\u9650\u4e8e\u5bf9\u75be\u75c5\u76f8\u5173\u57fa\u56e0\u7684\u9274\u5b9a\uff0c\u66f4\u662f\u5bf9\u5229\u7528\u75be\u75c5\u76f8\u5173Hub\u57fa\u56e0\u8fdb\u884c\u4e86\u836f\u7269\u9884\u6d4b\u548c\u75be\u75c5\u5173\u8054\uff0c\u63d0\u4f9b\u4e86\u76f8\u5e94\u7684\u6cbb\u7597\u6307\u5bfc\uff0c\u867d\u7136\u601d\u8def\u8f83\u4e3a\u7b80\u5355\uff0c\u4f46\u662f\u80dc\u5728\u4f1a\u6293\u70ed\u70b9\uff0c\u4f1a\u7ed3\u5408\u76f8\u5e94\u53d1\u6587\u5957\u8def\uff01\u601d\u8def\u7b80\u5355\u53ef\u590d\u523b\uff0c\u5404\u4f4d\u79d1\u7814\u6253\u5de5\u4eba\uff0c\u5feb\u51b2\uff01<\/span><o:p><\/o:p><\/p>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016839\" data-ratio=\"1\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-41.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'&from=appmsg\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016841\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/16_7TvAyUibd1TPhJmZfialJtv6tu2SEg-13.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100016840\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/17_9N02aBaau07RufXeXRLmvAHsrFZxtw-13.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;text-wrap: wrap;\" \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" 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