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Model\uff09\u662f\u7528\u4e8e\u751f\u5b58\u5206\u6790\u7684\u4e00\u79cd\u534a\u53c2\u6570\u6a21\u578b\u3002\u5b83\u8003\u8651\u4e86\u65f6\u95f4\u5230\u4e8b\u4ef6\u53d1\u751f\u7684\u6bd4\u4f8b\u98ce\u9669\uff0c\u5373\u67d0\u4e2a\u65f6\u95f4\u70b9\u4e0a\u4e8b\u4ef6\u53d1\u751f\u7684\u6982\u7387\u4e0e\u5176\u4ed6\u65f6\u95f4\u70b9\u76f8\u6bd4\u7684\u76f8\u5bf9\u98ce\u9669\u3002Cox\u6a21\u578b\u4e0d\u9700\u8981\u5047\u8bbe\u98ce\u9669\u6bd4\u5728\u65f6\u95f4\u4e0a\u662f\u6052\u5b9a\u7684\uff0c\u56e0\u6b64\u53ef\u4ee5\u9002\u7528\u4e8e\u5404\u79cd\u751f\u5b58\u6570\u636e\u7684\u5206\u6790\u3002<\/p>\n<p><br \/><\/p>\n<p>\u56e0\u6b64\u7ed3\u5408Cox\u56de\u5f52\u6a21\u578b\u540e\uff0c\u5176\u53ef\u4ee5\u7528\u4e8e\u540c\u65f6\u8fdb\u884c\u7279\u5f81\u9009\u62e9\u548c\u751f\u5b58\u9884\u6d4b\uff0c\u8fd9\u4f7f\u5f97Lasso-Cox\u56de\u5f52\u5728\u751f\u5b58\u5206\u6790\u4e2d\u5177\u6709\u72ec\u7279\u4f18\u52bf\uff0c\u80fd\u591f\u63a2\u7d22\u5f71\u54cd\u60a3\u8005\u751f\u5b58\u7387\u7684\u5173\u952e\u56e0\u7d20\uff0c\u4e3a\u4e2a\u4f53\u5316\u6cbb\u7597\u548c\u9884\u540e\u8bc4\u4f30\u63d0\u4f9b\u65b0\u7684\u89c6\u89d2\u548c\u7b56\u7565\u3002<\/p>\n<p><br \/><\/p>\n<p>\u4eca\u5929\u5927\u6d77\u54e5\u5c06\u901a\u8fc7\u4e00\u4e2a\u5b9e\u4f8b\u7ed9\u5c0f\u4f19\u4f34\u4eec\u6f14\u793a\u5176\u5728\u9884\u6d4b\u60a3\u8005\u751f\u5b58\u7387\u3001\u53d1\u73b0\u6f5c\u5728\u751f\u5b58\u76f8\u5173\u56e0\u7d20\u7b49\u65b9\u9762\u7684\u5f3a\u5927\u6f5c\u529b\u3002\u9996\u5148\u5206\u6790\u4e4b\u524d\u6211\u4eec\u9700\u8981\u51c6\u5907\u4e00\u4e2a\u81f3\u5c11\u5305\u542b\u4ee5\u4e0b\u5217\uff1aSurvivalTime\uff08\u751f\u5b58\u65f6\u95f4\uff09\u3001Status\uff08\u751f\u5b58\u72b6\u6001\uff0c1\u8868\u793a\u6b7b\u4ea1\uff0c0\u8868\u793a\u5b58\u6d3b\uff09\u3001\u5176\u4ed6\u4e34\u5e8a\u7279\u5f81\u5217\u4f5c\u4e3a\u9884\u6d4b\u53d8\u91cf\u7684\u4e34\u5e8a\u6570\u636e\u3002<\/p>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5927\u6d77\u54e5\u56fe\u4e2a\u65b9\u4fbf\uff0c\u968f\u673a\u751f\u6210\u4e00\u4e2a\u4e34\u5e8a\u6570\u636e^-^<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">clinical_data <- data.frame(SurvivalTime = sample(<span class=\"code-snippet__number\">100<\/span>:<span class=\"code-snippet__number\">5000<\/span>, <span class=\"code-snippet__number\">500<\/span>, replace = <span class=\"code-snippet__built_in\">T<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> Status=sample(<span class=\"code-snippet__number\">0<\/span>:<span class=\"code-snippet__number\">1<\/span>, <span class=\"code-snippet__number\">500<\/span>, replace = <span class=\"code-snippet__built_in\">T<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> edu=sample(<span class=\"code-snippet__number\">1<\/span>:<span class=\"code-snippet__number\">4<\/span>, <span class=\"code-snippet__number\">500<\/span>, replace = <span class=\"code-snippet__built_in\">T<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> BMI=rnorm(<span class=\"code-snippet__number\">500<\/span>, mean = <span class=\"code-snippet__number\">22<\/span>, sd = <span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> Age=sample(<span class=\"code-snippet__number\">10<\/span>:<span class=\"code-snippet__number\">80<\/span>, <span class=\"code-snippet__number\">500<\/span>,replace = <span class=\"code-snippet__built_in\">T<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u770b\u4e00\u4e0b\u6570\u636e,\u4e00\u5171\u6709500\u884c<\/span><\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.42407407407407405\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_MRbDVhVHy12LwQibxtXuWpq2bKMy8A.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/YHGRXkSxjSQzBaa9EYMN5pI1o2f7OprhFVp8iajJ5uKEul5xMFtl7SzZWdMRbDVhVHy12LwQibxtXuWpq2bKMy8A\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u7136\u540e\u5c31\u662f\u52a0\u8f7d\u6240\u9700\u8981\u7684\u5e93<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">library(survival)<\/span><\/code><code><span class=\"code-snippet_outer\">library(glmnet)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u7136\u540e\u9700\u8981\u505a\u4e00\u4e9b\u6570\u636e\u9884\u5904\u7406\uff0c\u786e\u4fdd\u9884\u6d4b\u53d8\u91cf\u4e3a\u6570\u503c\u578b\uff0c\u8fd9\u4e00\u6b65\u770b\u5177\u4f53\u60c5\u51b5\u54e6\uff01\u5927\u6d77\u54e5\u5c31\u4e0d\u9700\u8981\u7528\u4e86\uff0c\u5c0f\u4f19\u4f34\u4eec\u9700\u8981\u7684\u53ef\u4ee5\u76f4\u63a5\u4f7f\u7528\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#clinical_data$Age <- as.numeric(clinical_data$Age)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># clinical_data$BMI <- as.numeric(clinical_data$BMI)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u751f\u5b58\u65f6\u95f4\u548c\u72b6\u6001\u9700\u8981\u8f6c\u6362\u4e3adouble\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">clinical_data$SurvivalTime<-<span class=\"code-snippet__built_in\">as.double<\/span>(clinical_data$SurvivalTime)<\/span><\/code><code><span class=\"code-snippet_outer\">clinical_data$Status <- <span class=\"code-snippet__built_in\">as.double<\/span>(clinical_data$Status)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8bbe\u7f6e\u56e0\u53d8\u91cf\uff0c\u751f\u5b58\u65f6\u95f4\u548c\u751f\u5b58\u72b6\u6001\u4fe1\u606f<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">y<-data.matrix(Surv(time=clinical_data$SurvivalTime,event= clinical_data$Status))<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5173\u952e\u7684\u5730\u65b9\u5230\u4e86\uff0c\u5047\u8bbe\u6211\u4eec\u73b0\u5728\u8981\u4ece50\u4e2a\u514d\u75ab\u6b63\u76f8\u5173\u7684\u57fa\u56e0\u4e2d\u7b5b\u9009\u5177\u6709\u9884\u540e\u6548\u80fd\u7684\u57fa\u56e0\uff0c\u90a3\u4e48\u8fd9\u4e9b\u57fa\u56e0\u5728\u6837\u672c\u4e2d\u662f\u9ad8\u5ea6\u5171\u8868\u8fbe\u7684\uff0c\u4e5f\u5c31\u662f\u8bf4\u8fd9\u4e9b\u57fa\u56e0\u5b58\u5728\u5171\u7ebf\u6027\u5173\u7cfb\uff0c\u8fd9\u79cd\u60c5\u51b5\u6b63\u662f\u6700\u9002\u5408\u4f7f\u7528Lasso\u56de\u5f52<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8868\u8fbe\u8c31\u6570\u636e\u8fd9\u91cc\u6211\u4eec\u4f7f\u7528exp\u6765\u66ff\u4ee3\uff0c\u5927\u5bb6\u81ea\u884c\u5bfc\u5165\u54e6\uff01\u6ce8\u610f\u4e0d\u53ef\u4ee5\u6709\u7f3a\u5931\u503c\uff01\uff01\uff01\u5927\u6d77\u54e5\u5c31\u968f\u673a\u751f\u6210\u4e00\u4e2a\u5177\u6709\u7ebf\u6027\u5173\u7cfb\u7684\u6570\u636e<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u770b\u770bexp\u6570\u636e\u5427<\/span><\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.18425925925925926\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_sibsFhia4K7dibMJ0r18BR71VSNTbg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/YHGRXkSxjSQzBaa9EYMN5pI1o2f7OprhHLCmngRC4xezXYiaQ1yEQXOylrENsibsFhia4K7dibMJ0r18BR71VSNTbg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8fd9\u91cc\u9700\u8981\u6ce8\u610f\uff0c\u884c\u4e3a\u57fa\u56e0\uff0c\u5217\u4e3a\u6837\u672c\u54e6\uff01<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u8bbe\u7f6ealpha\u53c2\u6570\u4e3a1\uff0c\u5373LASSO\u56de\u5f52\uff0c\u5982\u679c\u4e3a0\u5c31\u662f\u5cad\u56de\u5f52\uff0c\u4e3a0-1\u4e4b\u95f4\u5c31\u662f\u5f39\u6027\u7f51\u7edc<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">alpha_value <- 1<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u5728\u6570\u636e\u96c6\u4e0a\u8fdb\u884cLasso-Cox\u56de\u5f52<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">lasso_cox_fit <- glmnet(x=<span class=\"code-snippet__built_in\">exp<\/span>, y,family=\u201dcox\u201d, alpha = alpha_value)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.5009259259259259\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_n7rBXibbBmV5oHulHBb8NdbxzK3ldg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/YHGRXkSxjSQzBaa9EYMN5pI1o2f7Oprhd5kpZ2NjlJugiaXnhaDDQoZycVn7rBXibbBmV5oHulHBb8NdbxzK3ldg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u770b\u770b\u4e0d\u540c\u57fa\u56e0\u968f\u7740lambda\u503c\u5f97\u53d8\u5316\u800c\u53d8\u5316\u7684\u8d8b\u52bf<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">plot(lasso_cox_fit,xvar=<span class=\"code-snippet__string\">\"lambda\"<\/span>,label=<span class=\"code-snippet__literal\">TRUE<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.9212962962962963\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_fkk27NYYcSXvlZ3MBDNvpMibNODQkg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/YHGRXkSxjSQzBaa9EYMN5pI1o2f7Oprh5ZlElL1CYbI8ZopKqFHib6iabWHfkk27NYYcSXvlZ3MBDNvpMibNODQkg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u6267\u884c\u4ea4\u53c9\u9a8c\u8bc1(\u8fd9\u4e00\u6b65\u4e00\u822c\u9700\u8981\u7a0d\u5fae\u7b49\u4e00\u4f1a\u4f1a\u54e6\uff01)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">final_lasso_cox_fit <- cv.glmnet(x=<span class=\"code-snippet__built_in\">exp<\/span>, y, family=\u2019cox\u2019,type.measure=\u2019deviance\u2019)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u8f93\u51fa\u7ed3\u679c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">plot(final_lasso_cox_fit,label=<span class=\"code-snippet__built_in\">T<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u53ef\u4ee5\u6839\u636e\u7cfb\u6570\u7684\u5927\u5c0f\u6765\u5224\u65ad\u54ea\u4e9b\u57fa\u56e0\u5bf9\u9884\u540e\u6709\u663e\u8457\u5f71\u54cd<\/span><\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9194444444444444\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_eOBpRmEjKfBib4iaiaLuBsHJ8nAIXQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/YHGRXkSxjSQzBaa9EYMN5pI1o2f7OprhVFqxuPEJlh6RcdtajibawVamF7WgeOBpRmEjKfBib4iaiaLuBsHJ8nAIXQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u73b0\u5728\u5c31\u53ef\u4ee5\u7b5b\u9009\u57fa\u56e0\u5566\uff01<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">coefficient <- coef(lasso_fit, s = lasso_fit$lambda.min)<\/span><\/code><code><span class=\"code-snippet_outer\">Active.Index<- which(<span class=\"code-snippet__built_in\">as.numeric<\/span>(coefficient)!= <span class=\"code-snippet__number\">0<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">active.coefficients <- <span class=\"code-snippet__built_in\">as.numeric<\/span>(coefficient)[Active.Index]<\/span><\/code><code><span class=\"code-snippet_outer\">sig_gene<-rownames(coefficient)[Active.Index]<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8f93\u51fa\u5173\u952e\u57fa\u56e0\u540d\uff08\u5927\u6d77\u54e5\u5c31\u4e0d\u8f93\u51fa\u4e86\uff0c\u56e0\u4e3a\u662f\u968f\u673a\u751f\u6210\u7684\u6570\u636e\uff09<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">sig_gene<\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section style=\"font-size: 14px;line-height: 1.8;letter-spacing: 2px;padding-right: 10px;padding-left: 10px;\" 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flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;line-height: 0;\">\n<section style=\"text-align: right;margin-right: 0%;margin-bottom: -20px;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 8px;height: 20px;vertical-align: top;overflow: hidden;border-width: 0px;border-style: none;border-color: rgb(62, 62, 62);background-color: rgb(245, 241, 224);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"text-align: center;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 16px;height: 20px;vertical-align: top;overflow: hidden;border-width: 0px;border-radius: 21px 21px 0px 0px;border-style: none;border-color: rgb(62, 62, 62);background-color: rgb(231, 215, 173);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;background-color: rgb(245, 241, 224);flex: 100 100 0%;align-self: flex-start;height: auto;border-right: 0px none rgb(62, 62, 62);border-top-right-radius: 12px;overflow: hidden;box-shadow: rgb(231, 215, 173) 0px 6px 0px;\">\n<section style=\"margin: 20px 0% 30px;\" powered-by=\"xiumi.us\">\n<section style=\"padding-right: 23px;padding-left: 23px;text-align: justify;font-size: 14px;letter-spacing: 1px;line-height: 1.8;\">\n<p>\u5b66\u4e60\u5b8c\u6bd5\uff0c\u5c0f\u4f19\u4f34\u4eec\u6709\u6ca1\u6709\u4eb2\u81ea\u52a8\u624b\u8bd5\u4e00\u8bd5\u5462\uff1f\u4e66\u8bfb\u767e\u904d\uff0c\u624d\u80fd\u5176\u4e49\u81ea\u89c1\u3002\u5206\u6790\u4e5f\u662f\u4e00\u6837\u7684\uff0c\u53ea\u6709\u591a\u5c1d\u8bd5\u51e0\u904d\uff0c\u624d\u80fd\u9886\u609f\u5176\u4e2d\u7684\u5965\u79d8\u54e6\uff01\u6240\u4ee5\u5feb\u5feb\u884c\u52a8\u8d77\u6765\uff0c\u81ea\u5df1\u8bd5\u4e00\u8bd5\u5427\uff01\uff08<strong><span style=\"color: rgb(59, 149, 115);\">\u6700\u540e\u63a8\u8350\u4e00\u4e0b\u5927\u6d77\u54e5\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u4e91\u751f\u4fe1\u5206\u6790\u5de5\u5177\u5e73\u53f0\uff0c\u5305\u542b\u8d85\u591a\u96f6\u4ee3\u7801\u5c0f\u5de5\u5177\uff0c\u4e0a\u4f20\u6570\u636e\u4e00\u4ef6\u51fa\u56fe\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u6765\u53c2\u89c2\u54df\uff0c\u7f51\u5740\uff1ahttp:\/\/www.biocloudservice.com\/home.html<\/span><\/strong>\uff09<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"border-bottom: 2px solid rgb(0, 150, 136);text-align: left;font-size: 14px;\" powered-by=\"xiumi.us\">\n<p>\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\u8fdb\u5165\u7f51\u5740<\/p>\n<\/section>\n<section style=\"margin-left: 8%;margin-right: 8%;line-height: 1.1em;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;vertical-align: top;border-top: 1em solid rgb(0, 150, 136);border-left: 0.8em solid 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\/><\/p>\n<p>\u5927\u5bb6\u597d\u554a\uff0c\u6211\u662f\u5927\u6d77\u54e5\uff0c\u6211\u4eec\u90fd\u77e5\u9053\u4e34\u5e8a\u9884\u540e\u8bc4\u4f30\u4e00\u76f4\u662f\u533b\u5b66\u7814\u7a76\u4e2d\u7684\u91cd\u8981\u8bae\u9898\uff0c\u5bf9\u4e8e\u60a3\u8005\u7684\u6cbb\u7597\u9009\u62e9\u548c\u75be\u75c5\u7ba1\u7406\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u7ed3\u5408\u4e34\u5e8a\u5c55\u5f00\u5206\u6790\u4e5f\u4e00\u76f4\u662f\u751f\u4fe1\u5206\u6790\u7684\u4e00\u5927\u70ed\u70b9\u3002\u90a3\u4e48\u9009\u62e9\u4ec0\u4e48\u65b9\u6cd5\u6765\u5bf9\u4e34\u5e8a\u4fe1\u606f\u505a\u9884\u540e\u5206\u6790\u5462\uff1f\u4eca\u5929\u5927\u6d77\u54e5\u5c31\u63a8\u8350\u4e00\u4e2a\u66fe\u5f15\u8d77\u533b\u5b66\u754c\u5e7f\u6cdb\u5173\u6ce8\u7684Lasso-Cox\u56de\u5f52\u5206\u6790\u3002\u4e86\u89e3Lasso-Cox\u4e4b\u524d\uff0c\u6211\u4eec\u9700\u8981\u5148\u5206\u522b\u4e86\u89e3\u4e00\u4e0bLasso\u56de\u5f52\u548cCox\u6bd4\u4f8b\u98ce\u9669\u6a21\u578b\u3002<\/p>\n<p><br \/><\/p>\n<p>Lasso\uff08Least Absolute Shrinkage and Selection Operator\uff09\u56de\u5f52\u662f\u4e00\u79cd\u7ebf\u6027\u56de\u5f52\u7684\u6539\u8fdb\u7b97\u6cd5\uff0c\u5b83\u5728\u666e\u901a\u7ebf\u6027\u56de\u5f52\u7684\u57fa\u7840\u4e0a\u6dfb\u52a0\u4e86\u4e00\u4e2a\u60e9\u7f5a\u9879\u3002Lasso\u56de\u5f52\u7684\u76ee\u6807\u662f\u6700\u5c0f\u5316\u635f\u5931\u51fd\u6570\u548cL1\u8303\u6570\u7684\u7ec4\u5408\u3002L1\u8303\u6570\u662f\u6307\u53c2\u6570\u5411\u91cf\u4e2d\u5404\u4e2a\u53c2\u6570\u7edd\u5bf9\u503c\u4e4b\u548c\u3002\u8fd9\u4e2a\u989d\u5916\u7684L1\u60e9\u7f5a\u4f7f\u5f97Lasso\u56de\u5f52\u80fd\u591f\u5c06\u4e00\u4e9b\u4e0d\u76f8\u5173\u7684\u7279\u5f81\u7684\u7cfb\u6570\u538b\u7f29\u5230\u96f6\uff0c\u4ece\u800c\u5b9e\u73b0\u7279\u5f81\u9009\u62e9\u7684\u529f\u80fd\u3002\u8fd9\u5bf9\u4e8e\u9ad8\u7ef4\u6570\u636e\u96c6\u6216\u8005\u7279\u5f81\u8f83\u591a\u7684\u95ee\u9898\u975e\u5e38\u6709\u7528\u3002\u800cCox\u662f\u4ec0\u4e48\u5462\uff1fCox\u6bd4\u4f8b\u98ce\u9669\u6a21\u578b\uff08Cox Proportional Hazards Model\uff09\u662f\u7528\u4e8e\u751f\u5b58\u5206\u6790\u7684\u4e00\u79cd\u534a\u53c2\u6570\u6a21\u578b\u3002\u5b83\u8003\u8651\u4e86\u65f6\u95f4\u5230\u4e8b\u4ef6\u53d1\u751f\u7684\u6bd4\u4f8b\u98ce\u9669\uff0c\u5373\u67d0\u4e2a\u65f6\u95f4\u70b9\u4e0a\u4e8b\u4ef6\u53d1\u751f\u7684\u6982\u7387\u4e0e\u5176\u4ed6\u65f6\u95f4\u70b9\u76f8\u6bd4\u7684\u76f8\u5bf9\u98ce\u9669\u3002Cox\u6a21\u578b\u4e0d\u9700\u8981\u5047\u8bbe\u98ce\u9669\u6bd4\u5728\u65f6\u95f4\u4e0a\u662f\u6052\u5b9a\u7684\uff0c\u56e0\u6b64\u53ef\u4ee5\u9002\u7528\u4e8e\u5404\u79cd\u751f\u5b58\u6570\u636e\u7684\u5206\u6790\u3002<\/p>\n<p><br \/><\/p>\n<p>\u56e0\u6b64\u7ed3\u5408Cox\u56de\u5f52\u6a21\u578b\u540e\uff0c\u5176\u53ef\u4ee5\u7528\u4e8e\u540c\u65f6\u8fdb\u884c\u7279\u5f81\u9009\u62e9\u548c\u751f\u5b58\u9884\u6d4b\uff0c\u8fd9\u4f7f\u5f97Lasso-Cox\u56de\u5f52\u5728\u751f\u5b58\u5206\u6790\u4e2d\u5177\u6709\u72ec\u7279\u4f18\u52bf\uff0c\u80fd\u591f\u63a2\u7d22\u5f71\u54cd\u60a3\u8005\u751f\u5b58\u7387\u7684\u5173\u952e\u56e0\u7d20\uff0c\u4e3a\u4e2a\u4f53\u5316\u6cbb\u7597\u548c\u9884\u540e\u8bc4\u4f30\u63d0\u4f9b\u65b0\u7684\u89c6\u89d2\u548c\u7b56\u7565\u3002<\/p>\n<p><br \/><\/p>\n<p>\u4eca\u5929\u5927\u6d77\u54e5\u5c06\u901a\u8fc7\u4e00\u4e2a\u5b9e\u4f8b\u7ed9\u5c0f\u4f19\u4f34\u4eec\u6f14\u793a\u5176\u5728\u9884\u6d4b\u60a3\u8005\u751f\u5b58\u7387\u3001\u53d1\u73b0\u6f5c\u5728\u751f\u5b58\u76f8\u5173\u56e0\u7d20\u7b49\u65b9\u9762\u7684\u5f3a\u5927\u6f5c\u529b\u3002\u9996\u5148\u5206\u6790\u4e4b\u524d\u6211\u4eec\u9700\u8981\u51c6\u5907\u4e00\u4e2a\u81f3\u5c11\u5305\u542b\u4ee5\u4e0b\u5217\uff1aSurvivalTime\uff08\u751f\u5b58\u65f6\u95f4\uff09\u3001Status\uff08\u751f\u5b58\u72b6\u6001\uff0c1\u8868\u793a\u6b7b\u4ea1\uff0c0\u8868\u793a\u5b58\u6d3b\uff09\u3001\u5176\u4ed6\u4e34\u5e8a\u7279\u5f81\u5217\u4f5c\u4e3a\u9884\u6d4b\u53d8\u91cf\u7684\u4e34\u5e8a\u6570\u636e\u3002<\/p>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5927\u6d77\u54e5\u56fe\u4e2a\u65b9\u4fbf\uff0c\u968f\u673a\u751f\u6210\u4e00\u4e2a\u4e34\u5e8a\u6570\u636e^-^<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">clinical_data <- data.frame(SurvivalTime = sample(<span class=\"code-snippet__number\">100<\/span>:<span class=\"code-snippet__number\">5000<\/span>, <span class=\"code-snippet__number\">500<\/span>, replace = <span class=\"code-snippet__built_in\">T<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> Status=sample(<span class=\"code-snippet__number\">0<\/span>:<span class=\"code-snippet__number\">1<\/span>, <span class=\"code-snippet__number\">500<\/span>, replace = <span class=\"code-snippet__built_in\">T<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> edu=sample(<span class=\"code-snippet__number\">1<\/span>:<span class=\"code-snippet__number\">4<\/span>, <span class=\"code-snippet__number\">500<\/span>, replace = <span class=\"code-snippet__built_in\">T<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> BMI=rnorm(<span class=\"code-snippet__number\">500<\/span>, mean = <span class=\"code-snippet__number\">22<\/span>, sd = <span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> Age=sample(<span class=\"code-snippet__number\">10<\/span>:<span class=\"code-snippet__number\">80<\/span>, <span class=\"code-snippet__number\">500<\/span>,replace = <span class=\"code-snippet__built_in\">T<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u770b\u4e00\u4e0b\u6570\u636e,\u4e00\u5171\u6709500\u884c<\/span><\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.42407407407407405\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_MRbDVhVHy12LwQibxtXuWpq2bKMy8A.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/YHGRXkSxjSQzBaa9EYMN5pI1o2f7OprhFVp8iajJ5uKEul5xMFtl7SzZWdMRbDVhVHy12LwQibxtXuWpq2bKMy8A\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u7136\u540e\u5c31\u662f\u52a0\u8f7d\u6240\u9700\u8981\u7684\u5e93<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">library(survival)<\/span><\/code><code><span class=\"code-snippet_outer\">library(glmnet)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u7136\u540e\u9700\u8981\u505a\u4e00\u4e9b\u6570\u636e\u9884\u5904\u7406\uff0c\u786e\u4fdd\u9884\u6d4b\u53d8\u91cf\u4e3a\u6570\u503c\u578b\uff0c\u8fd9\u4e00\u6b65\u770b\u5177\u4f53\u60c5\u51b5\u54e6\uff01\u5927\u6d77\u54e5\u5c31\u4e0d\u9700\u8981\u7528\u4e86\uff0c\u5c0f\u4f19\u4f34\u4eec\u9700\u8981\u7684\u53ef\u4ee5\u76f4\u63a5\u4f7f\u7528\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#clinical_data$Age <- as.numeric(clinical_data$Age)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># clinical_data$BMI <- as.numeric(clinical_data$BMI)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u751f\u5b58\u65f6\u95f4\u548c\u72b6\u6001\u9700\u8981\u8f6c\u6362\u4e3adouble\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">clinical_data$SurvivalTime<-<span class=\"code-snippet__built_in\">as.double<\/span>(clinical_data$SurvivalTime)<\/span><\/code><code><span class=\"code-snippet_outer\">clinical_data$Status <- <span class=\"code-snippet__built_in\">as.double<\/span>(clinical_data$Status)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8bbe\u7f6e\u56e0\u53d8\u91cf\uff0c\u751f\u5b58\u65f6\u95f4\u548c\u751f\u5b58\u72b6\u6001\u4fe1\u606f<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">y<-data.matrix(Surv(time=clinical_data$SurvivalTime,event= clinical_data$Status))<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5173\u952e\u7684\u5730\u65b9\u5230\u4e86\uff0c\u5047\u8bbe\u6211\u4eec\u73b0\u5728\u8981\u4ece50\u4e2a\u514d\u75ab\u6b63\u76f8\u5173\u7684\u57fa\u56e0\u4e2d\u7b5b\u9009\u5177\u6709\u9884\u540e\u6548\u80fd\u7684\u57fa\u56e0\uff0c\u90a3\u4e48\u8fd9\u4e9b\u57fa\u56e0\u5728\u6837\u672c\u4e2d\u662f\u9ad8\u5ea6\u5171\u8868\u8fbe\u7684\uff0c\u4e5f\u5c31\u662f\u8bf4\u8fd9\u4e9b\u57fa\u56e0\u5b58\u5728\u5171\u7ebf\u6027\u5173\u7cfb\uff0c\u8fd9\u79cd\u60c5\u51b5\u6b63\u662f\u6700\u9002\u5408\u4f7f\u7528Lasso\u56de\u5f52<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8868\u8fbe\u8c31\u6570\u636e\u8fd9\u91cc\u6211\u4eec\u4f7f\u7528exp\u6765\u66ff\u4ee3\uff0c\u5927\u5bb6\u81ea\u884c\u5bfc\u5165\u54e6\uff01\u6ce8\u610f\u4e0d\u53ef\u4ee5\u6709\u7f3a\u5931\u503c\uff01\uff01\uff01\u5927\u6d77\u54e5\u5c31\u968f\u673a\u751f\u6210\u4e00\u4e2a\u5177\u6709\u7ebf\u6027\u5173\u7cfb\u7684\u6570\u636e<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u770b\u770bexp\u6570\u636e\u5427<\/span><\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.18425925925925926\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_sibsFhia4K7dibMJ0r18BR71VSNTbg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/YHGRXkSxjSQzBaa9EYMN5pI1o2f7OprhHLCmngRC4xezXYiaQ1yEQXOylrENsibsFhia4K7dibMJ0r18BR71VSNTbg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8fd9\u91cc\u9700\u8981\u6ce8\u610f\uff0c\u884c\u4e3a\u57fa\u56e0\uff0c\u5217\u4e3a\u6837\u672c\u54e6\uff01<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u8bbe\u7f6ealpha\u53c2\u6570\u4e3a1\uff0c\u5373LASSO\u56de\u5f52\uff0c\u5982\u679c\u4e3a0\u5c31\u662f\u5cad\u56de\u5f52\uff0c\u4e3a0-1\u4e4b\u95f4\u5c31\u662f\u5f39\u6027\u7f51\u7edc<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">alpha_value <- 1<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u5728\u6570\u636e\u96c6\u4e0a\u8fdb\u884cLasso-Cox\u56de\u5f52<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">lasso_cox_fit <- glmnet(x=<span class=\"code-snippet__built_in\">exp<\/span>, y,family=\u201dcox\u201d, alpha = alpha_value)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.5009259259259259\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_n7rBXibbBmV5oHulHBb8NdbxzK3ldg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/YHGRXkSxjSQzBaa9EYMN5pI1o2f7Oprhd5kpZ2NjlJugiaXnhaDDQoZycVn7rBXibbBmV5oHulHBb8NdbxzK3ldg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u770b\u770b\u4e0d\u540c\u57fa\u56e0\u968f\u7740lambda\u503c\u5f97\u53d8\u5316\u800c\u53d8\u5316\u7684\u8d8b\u52bf<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">plot(lasso_cox_fit,xvar=<span class=\"code-snippet__string\">\"lambda\"<\/span>,label=<span class=\"code-snippet__literal\">TRUE<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.9212962962962963\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_fkk27NYYcSXvlZ3MBDNvpMibNODQkg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/YHGRXkSxjSQzBaa9EYMN5pI1o2f7Oprh5ZlElL1CYbI8ZopKqFHib6iabWHfkk27NYYcSXvlZ3MBDNvpMibNODQkg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u6267\u884c\u4ea4\u53c9\u9a8c\u8bc1(\u8fd9\u4e00\u6b65\u4e00\u822c\u9700\u8981\u7a0d\u5fae\u7b49\u4e00\u4f1a\u4f1a\u54e6\uff01)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">final_lasso_cox_fit <- cv.glmnet(x=<span class=\"code-snippet__built_in\">exp<\/span>, y, family=\u2019cox\u2019,type.measure=\u2019deviance\u2019)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u8f93\u51fa\u7ed3\u679c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">plot(final_lasso_cox_fit,label=<span class=\"code-snippet__built_in\">T<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u53ef\u4ee5\u6839\u636e\u7cfb\u6570\u7684\u5927\u5c0f\u6765\u5224\u65ad\u54ea\u4e9b\u57fa\u56e0\u5bf9\u9884\u540e\u6709\u663e\u8457\u5f71\u54cd<\/span><\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9194444444444444\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_eOBpRmEjKfBib4iaiaLuBsHJ8nAIXQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/YHGRXkSxjSQzBaa9EYMN5pI1o2f7OprhVFqxuPEJlh6RcdtajibawVamF7WgeOBpRmEjKfBib4iaiaLuBsHJ8nAIXQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u73b0\u5728\u5c31\u53ef\u4ee5\u7b5b\u9009\u57fa\u56e0\u5566\uff01<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">coefficient <- coef(lasso_fit, s = lasso_fit$lambda.min)<\/span><\/code><code><span class=\"code-snippet_outer\">Active.Index<- which(<span class=\"code-snippet__built_in\">as.numeric<\/span>(coefficient)!= <span class=\"code-snippet__number\">0<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">active.coefficients <- <span class=\"code-snippet__built_in\">as.numeric<\/span>(coefficient)[Active.Index]<\/span><\/code><code><span class=\"code-snippet_outer\">sig_gene<-rownames(coefficient)[Active.Index]<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8f93\u51fa\u5173\u952e\u57fa\u56e0\u540d\uff08\u5927\u6d77\u54e5\u5c31\u4e0d\u8f93\u51fa\u4e86\uff0c\u56e0\u4e3a\u662f\u968f\u673a\u751f\u6210\u7684\u6570\u636e\uff09<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">sig_gene<\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 12px;line-height: 0;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<section style=\"font-size: 14px;line-height: 1.8;letter-spacing: 2px;padding-right: 10px;padding-left: 10px;\" powered-by=\"xiumi.us\">\n<p>#\u6574\u4f53\u7684\u5206\u6790\u5c31\u7ed3\u675f\u5566\uff01\u5f88\u591a\u5c0f\u4f19\u4f34\u80af\u5b9a\u5c31\u4f1a\u95ee\uff0c\u4e3a\u4ec0\u4e48\u8981\u4f7f\u7528\u8fd9\u79cd\u65b9\u6cd5\u6765\u7b5b\u9009\u5462\uff1f\u5176\u5b9e\u662f\u56e0\u4e3aLasso-Cox\u56de\u5f52\u62e5\u6709\u7740\u4e00\u4e9b\u5176\u4ed6\u65b9\u6cd5\u6ca1\u6709\u7684\u4f18\u70b9\uff0c \u9996\u5148asso\u53ef\u4ee5\u81ea\u52a8\u9009\u62e9\u6700\u91cd\u8981\u7684\u7279\u5f81\uff0c\u5c06\u4e0d\u76f8\u5173\u7684\u7279\u5f81\u7684\u7cfb\u6570\u7f29\u51cf\u4e3a0\uff0c\u4ece\u800c\u964d\u4f4e\u4e86\u6a21\u578b\u590d\u6742\u6027\uff0c\u540c\u65f6\u5f53\u8f93\u5165\u7279\u5f81\u4e4b\u95f4\u5b58\u5728\u591a\u91cd\u5171\u7ebf\u6027\u65f6\uff0cLasso\u53ef\u4ee5\u6709\u6548\u5730\u5904\u7406\uff0c\u5e76\u907f\u514d\u4f30\u8ba1\u8fc7\u9ad8\u7684\u7cfb\u6570\u3002\u5176\u6b21Lasso-Cox\u901a\u8fc7\u4f7f\u7528Cox\u6bd4\u4f8b\u98ce\u9669\u6a21\u578b\uff0cLasso-Cox\u53ef\u4ee5\u5904\u7406\u65f6\u95f4\u76f8\u5173\u7684\u751f\u5b58\u6570\u636e\uff0c\u907f\u514d\u4e86\u5047\u8bbe\u98ce\u9669\u6bd4\u662f\u5e38\u6570\u7684\u9650\u5236\u3002\u6b63\u662f\u56e0\u4e3a\u8fd9\u4e9b\u4f18\u52bf\uff0c\u4f7f\u5f97Lasso-Cox\u5728\u5904\u7406\u751f\u5b58\u6570\u636e\u65f6\u66f4\u52a0\u5168\u9762\u548c\u6709\u6548\u3002<\/p>\n<p><br \/><\/p>\n<p>\u90a3\u4e48\u5728\u5206\u6790\u8fc7\u7a0b\u4e2d\u9700\u8981\u6ce8\u610f\u4ec0\u4e48\u5462\uff1f<\/p>\n<p>\u8fd9\u91cc\u5927\u6d77\u54e5\u9700\u8981\u63d0\u9192\u5927\u5bb6\uff0cLasso-Cox\u65b9\u6cd5\u5728\u4f7f\u7528\u65f6\u9700\u8981\u8fdb\u884c\u8c03\u53c2\uff0c\u4f8b\u5982\u9009\u62e9\u5408\u9002\u7684L1\u60e9\u7f5a\u53c2\u6570\u3002\u6b64\u5916\uff0c\u5b83\u4e5f\u6709\u4e00\u4e9b\u9650\u5236\uff0c\u6bd4\u5982\u5bf9\u4e8e\u8f83\u5c0f\u7684\u6837\u672c\u91cf\u548c\u4e25\u91cd\u7684\u5171\u7ebf\u6027\u53ef\u80fd\u8868\u73b0\u4e0d\u4f73\u3002\u56e0\u6b64\uff0c\u5728\u5e94\u7528Lasso-Cox\u65b9\u6cd5\u65f6\uff0c\u4ecd\u7136\u9700\u8981\u4ed4\u7ec6\u8003\u8651\u6570\u636e\u7684\u7279\u70b9\u548c\u6a21\u578b\u7684\u8c03\u6574\u3002\u6240\u4ee5\u6709\u4e9b\u5730\u65b9\u9700\u8981\u81ea\u5df1\u597d\u597d\u7422\u78e8\u4e00\u4e8c\u54e6\uff01<\/p>\n<p><br \/><\/p>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin: 10px 0% 20px;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;align-self: flex-start;line-height: 0;\">\n<section style=\"text-align: right;margin-right: 0%;margin-bottom: -20px;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 8px;height: 20px;vertical-align: top;overflow: hidden;border-width: 0px;border-style: none;border-color: rgb(62, 62, 62);background-color: rgb(245, 241, 224);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"text-align: center;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 16px;height: 20px;vertical-align: top;overflow: hidden;border-width: 0px;border-radius: 21px 21px 0px 0px;border-style: none;border-color: rgb(62, 62, 62);background-color: rgb(231, 215, 173);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;background-color: rgb(245, 241, 224);flex: 100 100 0%;align-self: flex-start;height: auto;border-right: 0px none rgb(62, 62, 62);border-top-right-radius: 12px;overflow: hidden;box-shadow: rgb(231, 215, 173) 0px 6px 0px;\">\n<section style=\"margin: 20px 0% 30px;\" powered-by=\"xiumi.us\">\n<section style=\"padding-right: 23px;padding-left: 23px;text-align: justify;font-size: 14px;letter-spacing: 1px;line-height: 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