{"id":54527,"date":"2024-06-16T14:17:22","date_gmt":"2024-06-16T06:17:22","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=54527"},"modified":"2024-06-16T14:17:22","modified_gmt":"2024-06-16T06:17:22","slug":"%e8%b6%85%e8%af%a6%e7%bb%86%e7%9a%84r%e4%b8%ad%e8%bf%9b%e8%a1%8cgsea%e5%88%86%e6%9e%90%e7%9a%84%e6%b5%81%e7%a8%8b%ef%bc%81%e4%b8%80%e7%9c%8b%e5%b0%b1%e4%bc%9a%ef%bc%81-4","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=54527","title":{"rendered":"\u8d85\u8be6\u7ec6\u7684R\u4e2d\u8fdb\u884cGSEA\u5206\u6790\u7684\u6d41\u7a0b\uff01\u4e00\u770b\u5c31\u4f1a\uff01"},"content":{"rendered":"


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none;\">GSEA\u5b98\u7f51\u63d0\u4f9b\u4e86\u4e00\u4e2a\u672c\u5730\u5206\u6790\u5de5\u5177\uff0c\u4f46\u662f\u8fd9\u4e2a\u5de5\u5177\u5728\u4f7f\u7528\u7684\u65f6\u5019\u51c6\u5907\u8f93\u5165\u6587\u4ef6\u6bd4\u8f83\u9ebb\u70e6\uff0c\u800c\u4e14\u51fa\u56fe\u4e5f\u662f\u4e00\u4e2a\u901a\u8def\u4e00\u5f20\u56fe\uff0c\u90a3\u6709\u6ca1\u6709\u4e00\u79cd\u66f4\u597d\u7684\u65b9\u6cd5\u5462\uff1f\u5c0f\u679c\u4eca\u5929\u5c31\u5e26\u7740\u5927\u5bb6\u6765\u5b66\u4e60\u4e00\u4e0b\u7528R\u8bed\u8a00\u5f00\u5c55GSEA\u5206\u6790\u5427\uff01<\/span><span style=\"font-family: "Times New Roman";letter-spacing: 0.034em;\"> <\/span><\/span><\/section>\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\"><strong><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u7b2c\u4e00\u6b65\uff1a\u8f93\u5165\u6587\u4ef6\u51c6\u5907<\/span><\/strong><\/span><\/section>\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u8fd9\u91cc\u6211\u4eec\u53ef\u4ee5\u76f4\u63a5\u4f7f\u7528limma\u5dee\u5f02\u5206\u6790\u540e\u7684\u7ed3\u679c\u6587\u4ef6\uff0c\u6211\u4eec\u53ea\u9700\u8981\u524d\u4e24\u5217\u5185\u5bb9\u5c31\u53ef\u4ee5\u4e86\u3002\u5982\u679c\u4e0d\u77e5\u9053\u600e\u4e48\u4f7f\u7528limma\u8fdb\u884c\u5dee\u5f02\u5206\u6790\u7684\u53ef\u4ee5\u770b\u4e00\u4e0b\u5c0f\u679c\u4ee5\u524d\u7684\u63a8\u6587\u3002<\/span>   <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;font-size: 16px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100014976\" data-ratio=\"0.43916083916083914\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_eph0AXBugcmQdibeiaPSajNHk8HUtw-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAwA8f7y7NSpZrnNlwLF9CD0R4nygehPES5hXX4jWLgT82xuOSeph0AXBugcmQdibeiaPSajNHk8HUtw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"715\" height=\"243.07000732421875\" width=\"553.4099731445312\" \/><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;font-size: 16px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100014975\" data-ratio=\"1.5\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_X1zjwVTA0tGtugxcxtTiaRGb61qGRg-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAwA8f7y7NSpZrnNlwLF9CD0bRf4Y4rQDSLTxnOFo618icgWAnX1zjwVTA0tGtugxcxtTiaRGb61qGRg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"146\" height=\"219.0\" width=\"146.0\" \/><\/span><\/section>\n<section style=\"text-indent: 0em;text-align: left;margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;break-after: auto;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\"><strong> <\/strong><strong>\u7b2c\u4e8c\u6b65\uff1a\u914d\u7f6e\u6240\u9700\u7684R\u5305<\/strong><\/span><\/section>\n<pre style=\"\"><section style=\"text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\"> \u6240\u9700R\u5305\u5747\u53ef\u4ee5\u7528BiocManager\u5305\u5b89\u88c5\uff0c\u5982\u679c\u6ca1\u6709BiocManager\u5305\uff0c\u53ef\u4ee5\u7528\u4ee5\u4e0b\u547d\u4ee4\u5b89\u88c5\u3002<\/span><\/section><\/pre>\n<pre><\/pre>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"sql\"><section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">if (!requireNamespace(\"BiocManager\", quietly = TRUE))<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\"> install.packages(\"BiocManager\") #\u5b89\u88c5BiocManager\u5305<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">BiocManager::install(\"clusterProfiler\") #\u5b89\u88c5\u5206\u6790\u6240\u9700R\u5305<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">library(ReactomePA) #\u52a0\u8f7d\u6240\u9700R\u5305<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">library(tidyverse)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">library(data.table)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">library(org.Hs.eg.db)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">library(clusterProfiler)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">library(biomaRt)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">library(enrichplot)<\/span><\/span><\/code><\/section><\/pre>\n<\/section>\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\">   <strong><span style=\"letter-spacing: 0.034em;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u7b2c\u4e09\u6b65\uff1a\u5bfc\u5165\u6570\u636e\u5e76\u8fdb\u884c\u9884\u5904\u7406<\/span><span style=\"letter-spacing: 0.034em;\">  <\/span><\/strong><span style=\"letter-spacing: 0.034em;\">  <\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\"><span style=\"font-family: \u5b8b\u4f53;text-align: left;text-indent: 0pt;letter-spacing: 0.034em;\">\u5728\u8fdb\u884cGSEA\u5206\u6790\u4e4b\u524d\u6211\u4eec\u8fd8<\/span><span style=\"font-family: \u5b8b\u4f53;text-align: left;text-indent: 0pt;letter-spacing: 0.034em;\">\u9700\u8981\u5bf9\u8f93\u5165\u6587\u4ef6\u8fdb\u884c\u4e00\u4e2a\u9884\u5904\u7406\uff0c\u4e3b\u8981\u5c31\u662f\u5c06\u6587\u4ef6\u4e2d\u7b2c\u4e00\u5217SYMBOL\u683c\u5f0f\u7684ID\u6362\u6210ENTREZ\u683c\u5f0f\u7684ID\uff0c\u540c\u65f6\u5c06ENTREZID\u4e0elogFC\u7ed3\u5408\uff0c\u5e76\u6839\u636elogFC\u7684\u503c\u8fdb\u884c\u964d\u5e8f\u6392\u5217\uff0c\u6700\u540e\u5c06\u7ed3\u679c\u6574\u7406\u6210GSEA\u5206\u6790\u6240\u9700\u7684\u683c\u5f0f\uff0c\u5c31\u53ef\u4ee5\u7528\u4e8e\u540e\u7eed\u5206\u6790\u4e86\u3002\u4e0b\u9762\u8ddf\u7740\u5c0f\u679c\u4e00\u8d77\u6765\u64cd\u4f5c\u4e00\u4e0b\u5427\uff01<\/span><\/span><\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"cs\"><section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">setwd(\"G:\/job\/job1\/GSEA\/\") #\u8fdb\u5165\u5b58\u653e\u6570\u636e\u7684\u5de5\u4f5c\u76ee\u5f55<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">genelist_input <- fread(file=\"GSEA.txt\", header = T, sep='t', data.table = F) #\u5bfc\u5165\u6570\u636e<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">genename <- as.character(genelist_input[,1]) #\u63d0\u53d6\u7b2c\u4e00\u5217\u57fa\u56e0\u540d<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">gene_map <- select(org.Hs.eg.db, keys=genename, keytype=\"SYMBOL\", columns=c(\"ENTREZID\")) #\u5c06SYMBOL\u683c\u5f0f\u7684ID\u6362\u6210ENTREZ\u683c\u5f0f\u7684ID\u3002<\/span><\/span><\/code><\/section><\/pre>\n<\/section>\n<section style=\"text-align: justify;text-indent: 24pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\"><span style=\"font-family: \u5b8b\u4f53;text-indent: 24pt;letter-spacing: 0.034em;\">\uff08\u6ce8\u610f\uff1a\u8fd9\u4e00\u6b65\u8fd0\u884c\u7ed3\u679c\u6b63\u5e38\u60c5\u51b5\u5c31\u662f1:1 mapping\uff0c\u5982\u56fe\u6240\u793a\u3002\u4f46\u662f\u4e5f\u6709\u4f1a\u51fa\u73b01\uff1amany mapping\u7684\u60c5\u51b5\uff0c\u5982\u56fe\u793a\uff0c\u8fd9\u79cd\u60c5\u51b5\u53ef\u80fd\u4f1a\u5f71\u54cd\u540e\u7eed\u5206\u6790\u7ed3\u679c\uff0c\u540c\u65f6\u6709\u4e9b\u5206\u6790\u4e5f\u65e0\u6cd5\u8fdb\u884c\uff0c\u56e0\u6b64\u6211\u4eec\u53ef\u4ee5\u8fdb\u884c\u53bb\u91cd\u590d\u64cd\u4f5c\uff0c\u518d\u7ee7\u7eed\u540e\u7eed\u5206\u6790\u3002\uff09<\/span><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100014974\" data-ratio=\"0.05006765899864682\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_1WSGD8ONO9KlcW3sMfVrVuOI3fYpcQ-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAwA8f7y7NSpZrnNlwLF9CD0YVCRmibbKJmSys3lAHTeMRUPg1WSGD8ONO9KlcW3sMfVrVuOI3fYpcQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"739\" height=\"27.72998046875\" width=\"553.5399780273438\" \/><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100014978\" data-ratio=\"0.04654255319148936\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_IumsX2Ez89twNBuAj9TRca5R0uG8Yg-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAwA8f7y7NSpZrnNlwLF9CD0PWbIp5lvXzD9ZaINeHRIQaDbIumsX2Ez89twNBuAj9TRca5R0uG8Yg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"752\" height=\"25.72998046875\" width=\"553.47998046875\" \/><\/span><\/section>\n<p style=\"text-align:justify;text-justify:inter-ideograph;text-indent:21.0pt;mso-char-indent-count:2.0;mso-char-indent-size:10.5;\"><br \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"bash\"><section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">non_duplicates_idx <- which(duplicated(gene_map$SYMBOL) == FALSE) <\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">gene_map <- gene_map[non_duplicates_idx, ] #\u53bb\u9664\u91cd\u590d\u503c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">colnames(gene_map)[1]<-\"Gene\" #\u8f93\u51famapping\u7ed3\u679c<\/span><\/span><\/code><\/section><\/pre>\n<\/section>\n<section style=\"text-align: justify;text-indent: 21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;\"><\/span><\/section>\n<section style=\"text-align: center;text-indent: 21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100014977\" data-ratio=\"1.165680473372781\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_QpiaMgZ9WwcH7MAaBBRq7iaicQF9aw-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAwA8f7y7NSpZrnNlwLF9CD03Ep8hdpqOuJbc1ib4bau4cVH3ibvuQpiaMgZ9WwcH7MAaBBRq7iaicQF9aw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"169\" height=\"197.0\" width=\"169.0\" \/><\/span><span style=\"font-size: 16px;\">    <\/span><\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"perl\"><section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">#\u5c06ENTREZID\u4e0elogFC\u5bf9\u5e94\u8d77\u6765\uff0c\u5e76\u6839\u636elogFC\u7684\u503c\u964d\u5e8f\u6392\u5217\uff0c\u6700\u7ec8\u751f\u6210\u7ed3\u679c\u5982\u56fe\u6240\u793a\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">temp<-inner_join(gene_map,genelist_input,by = \"Gene\")<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">temp<-temp[,-1]<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">temp<-na.omit(temp)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">temp$logFC<-sort(temp$logFC,decreasing = T)<\/span><\/span><\/code><\/section><\/pre>\n<\/section>\n<section style=\"text-align: justify;text-indent: 21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;\"><\/span><\/section>\n<section style=\"text-align: center;text-indent: 21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100014979\" data-ratio=\"1.4620689655172414\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_BWcGSVdibB2YSJC03EcAHoHUdGiabQ-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAwA8f7y7NSpZrnNlwLF9CD0xXCdDY2MDB9SRfibFk9EILicAWLCBWcGSVdibB2YSJC03EcAHoHUdGiabQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"145\" height=\"212.0\" width=\"145.0\" \/><\/span><\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"makefile\"><section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">#\u6700\u540e\u6211\u4eec\u5c06\u6587\u4ef6\u5185\u5bb9\u6574\u7406\u6210GSEA\u5206\u6790\u6240\u9700\u7684\u683c\u5f0f\uff08\u5982\u56fe\u6240\u793a\uff09\uff0c\u6211\u4eec\u5c31\u53ef\u4ee5\u5f00\u59cbGSEA\u5206\u6790\u4e86\uff01<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">geneList = temp[,2]<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">names(geneList) = as.character(temp[,1])<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\"> geneList<\/span><\/span><\/code><\/section><\/pre>\n<\/section>\n<section style=\"text-align: justify;text-indent: 21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;font-size: 16px;\"><\/span><\/section>\n<section style=\"text-align: center;text-indent: 21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100014980\" data-ratio=\"0.1322314049586777\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_BdpHfJTgyModJ5ibz8gnvJcSfe6b4g-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAwA8f7y7NSpZrnNlwLF9CD0QAJqermnCd2EibAjoagcZMRX01BdpHfJTgyModJ5ibz8gnvJcSfe6b4g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"726\" height=\"73.1300048828125\" width=\"553.2100219726562\" \/><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;text-align: justify;text-indent: 21pt;letter-spacing: 0.034em;\">         <\/span><o:p style=\"text-align: justify;text-indent: 21pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\"> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;\"><strong><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;\">  \u7b2c\u56db\u6b65\uff1a\u8fdb\u884cGSEA\u5206\u6790\uff0c\u5e76\u4fdd\u5b58\u7ed3\u679c\u3002<\/span><\/strong><\/span><\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"cs\"><section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">Go_gseresult <- gseGO(geneList, 'org.Hs.eg.db', keyType = \"ENTREZID\", ont=\"BP\", pvalueCutoff=0.05) #\u4f7f\u7528GSEA\u8fdb\u884cGO\u5bcc\u96c6\u5206\u6790\uff08'org.Hs.eg.db'\uff1a\u5bf9\u5e94\u7269\u79cd\u7684\u6570\u636e\u5e93\uff1bont\uff1a\u9009\u62e9\u8f93\u51fa\u6761\u76ee\uff0c\u53ef\u9009\u201cBP,MF,CC\u6216\u8005ALL\u201d\uff0cpvalueCutoff\uff1a\u8bbe\u7f6eP\u7684\u9608\u503c\uff09<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">KEGG_gseresult <- gseKEGG(geneList, pvalueCutoff=0.05) #\u4f7f\u7528GSEA\u8fdb\u884cKEGG\u5bcc\u96c6\u5206\u6790 <\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">#\u4fdd\u5b58\u5bcc\u96c6\u5206\u6790\u7ed3\u679c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">go_results<-as.data.frame(Go_gseresult)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">kegg_results<-as.data.frame(KEGG_gseresult)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">write.csv (go_results, file =\"Go_gseresult.csv\")<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">write.csv (kegg_results, file =\"KEGG_gseresult.csv\")<\/span><\/span><\/code><\/section><\/pre>\n<\/section>\n<section style=\"text-align: justify;text-indent: 21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;text-indent: 21pt;letter-spacing: 0.034em;font-size: 16px;\">    <\/span><o:p style=\"font-family: Calibri;text-indent: 21pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\"><span style=\"font-size: 16px;\"> <\/span><\/o:p><span style=\"font-size: 16px;\"><strong><span style=\"font-family: Calibri;letter-spacing: 0.034em;\">\u7b2c\u4e94\u6b65\uff1a\u7ed3\u679c\u53ef\u89c6\u5316\uff08\u4ee5GO\u5bcc\u96c6\u7ed3\u679c\u4e3a\u4f8b\uff09<\/span><\/strong><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;\">   \u8fd9\u91cc\u6211\u4eec\u4f7f\u7528\u7684\u662fgseaplot2\u5305\u8fdb\u884c\u7ed3\u679c\u53ef\u89c6\u5316\u5206\u6790\u3002\u5b83\u65e2\u53ef\u4ee5\u8f93\u51fa\u6307\u5b9a\u5355\u57fa\u56e0\u7684\u56fe\u7247\uff0c\u4e5f\u53ef\u4ee5\u8f93\u51fa\u5305\u542b\u591a\u6761\u57fa\u56e0\u7684\u56fe\u7247\u3002<\/span><\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"objectivec\"><section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><code><span class=\"code-snippet_outer\"><span style=\"font-size: 16px;\">gseaplot2(Go_gseresult, 1:3, title = \"Specific GO Biological Process in T2D group\", pvalue_table = FALSE) #1:3\uff1a\u8fd9\u8868\u793a\u5728\u56fe\u4e0a\u663e\u793a\u524d3\u6761\u5bcc\u96c6\u7ed3\u679c\uff0c\u4e5f\u53ef\u4ee5\u6839\u636e\u81ea\u5df1\u5206\u6790\u9700\u8981\u6307\u5b9a\u8f93\u51fa\u67d0\u4e00\u6761\u7ed3\u679c\uff1bGo_gseresult\uff1aGO\u5bcc\u96c6\u5206\u6790\u7ed3\u679c\uff1btitle\uff1a\u52a0\u4e0a\u6807\u9898\uff1bpvalue_table\uff1a\u662f\u5426\u5728\u56fe\u4e0a\u663e\u793aP\u503c\u5217\u8868\u3002<\/span><\/span><\/code><\/section><\/pre>\n<\/section>\n<section style=\"text-align: justify;text-indent: 21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;\"><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100014981\" data-ratio=\"0.8753501400560224\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_fPGB5389gJVoSUhsu2OvIIuDwvXEyg-3.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAwA8f7y7NSpZrnNlwLF9CD0jx7RNvicRI3iaZ6N8akZXSJRSffPGB5389gJVoSUhsu2OvIIuDwvXEyg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"714\" height=\"484.4100341796875\" width=\"553.3400268554688\" \/><\/span><span style=\"font-size: 16px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;\">\u81f3\u6b64\uff0c\u6211\u4eec\u7684GSEA\u5206\u6790\u5c31\u5b8c\u6210\u4e86\uff0c\u662f\u4e0d\u662f\u5f88\u7b80\u5355\u5440\uff01\u597d\u4e86\uff0c\u4eca\u5929\u5c0f\u679c\u7ed9\u5927\u5bb6\u5206\u4eab\u7684\u5185\u5bb9\u5c31\u5230\u8fd9\u91cc\u4e86\uff0c\u5927\u5bb6\u6709\u4ec0\u4e48\u95ee\u9898\u90fd\u53ef\u4ee5\u7559\u8a00\u8ba8\u8bba\u54e6\uff01\u6211\u4eec\u4e0b\u671f\u518d\u89c1\uff01<\/span><\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;\">\n<section powered-by=\"xiumi.us\">\n<section>\n<section>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018581\" data-ratio=\"1\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-43.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'&from=appmsg\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-wrap: wrap;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018583\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_7TvAyUibd1TPhJmZfialJtv6tu2SEg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\"><br \/><\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><o:page><\/o:page><\/section>\n<p style=\"display: none;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8d85\u8be6\u7ec6\u7684R\u4e2d\u8fdb\u884cGSEA\u5206\u6790\u7684\u6d41\u7a0b\uff01\u4e00\u770b\u5c31\u4f1a\uff01 \u5c0f\u82b1  \u751f\u4fe1\u679c  20 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/54527"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=54527"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/54527\/revisions"}],"predecessor-version":[{"id":54539,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/54527\/revisions\/54539"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=54527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=54527"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=54527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}