<\/title> \n<meta charset=\"utf-8\"> \n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,maximum-scale=1.0,user-scalable=0,viewport-fit=cover\"><\/p>\n<style>\n*{margin:0;padding:0}html{-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;line-height:1.6}img{z-index:999;position:relative;max-width:100%;margin:10px 0;}body{letter-spacing:.034em}h1,h2,h3,h4,h5,h6{font-weight:400;font-size:16px}a{color:#576b95;text-decoration:none;-webkit-tap-highlight-color:rgba(0,0,0,0)}td,th{word-wrap:break-word;padding:5px 10px;border:1px solid #DDD;}table{margin-bottom:10px;border-collapse:collapse;display:table;width:100%!important;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}.rich_media_area_primary{padding:20px 16px 12px;background-color:#fafafa}@media (max-width:375px){.rich_media_area_primary{padding:20px 60px 15px 60px}.rich_media_area_extra{padding:0 60px 21px 60px}}@media (min-width:1024px){.rich_media_area_primary_inner,.rich_media_area_extra_inner,body{max-width:677px;margin-left:auto;margin-right:auto}.rich_media_area_primary{padding-top:32px}}.rich_media{padding:20px;overflow:hidden;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}@media screen and (min-width:1024px){.rich_media_area_primary_inner,.rich_media_area_extra_inner{max-width:677px;margin-left:auto;margin-right:auto}.rich_media_area_primary{padding-top:32px}}.rich_media_content{overflow:hidden;color:#333;font-size:17px;word-wrap:break-word;-webkit-hyphens:auto;-ms-hyphens:auto;hyphens:auto;text-align:justify;position:relative;z-index:0}.rich_media_content *{max-width:100%!important;box-sizing:border-box!important;-webkit-box-sizing:border-box!important;word-wrap:break-word!important}.rich_media_content p{clear:both;min-height:1em}.rich_media_content em{font-style:italic}.rich_media_content fieldset{min-width:0}.rich_media_content .list-paddingleft-1,.rich_media_content .list-paddingleft-2,.rich_media_content .list-paddingleft-3{padding-left:2.2em}.rich_media_content .list-paddingleft-1 .list-paddingleft-2,.rich_media_content .list-paddingleft-2 .list-paddingleft-2,.rich_media_content .list-paddingleft-3 .list-paddingleft-2{padding-left:30px}.rich_media_content .list-paddingleft-1{padding-left:1.2em}.rich_media_content .list-paddingleft-3{padding-left:3.2em}.rich_media_content .code-snippet,.rich_media_content .code-snippet__fix{max-width:1000%!important}.rich_media_content .code-snippet *,.rich_media_content .code-snippet__fix *{max-width:1000%!important}.rich_media_title{font-size:22px;line-height:1.4;margin-bottom:13px;padding-bottom:13px;border-bottom:1px solid #e7e7eb;}@supports(-webkit-overflow-scrolling:touch){.rich_media_title{font-weight:700}}.rich_media_meta{display:inline-block;vertical-align:middle;padding:0 0 10px 0;font-size:15px;-webkit-tap-highlight-color:rgba(0,0,0,0)}.rich_media_meta.icon_appmsg_tag{margin-right:0px}.rich_media_meta.meta_tag_text{margin-right:0}.rich_media_meta_list em{font-style:normal}.rich_media_meta_text{color:#a5a5a5;}p{margin:0;}.msgBox{margin-top:20px;padding-top:20px;padding-left:50px;overflow:hidden;border-top:2px dashed #09a2ff;}.msg{padding-top:7px;clear:both;}.msgBody{float:right;width:100%;margin-left:55px;padding-bottom:15px;border-bottom:1px dashed #e0e0e0;}.userHeadImg{float:left;margin-left:-50px;}.userHeadImg img{width:40px;height:40px;margin-right:10px;border-radius:3px;}.userName{color:#888888;line-height:24px;font-size:14px;margin:5px 0 5px 0;height:24px;}.replyBody,.autherBody{color:#565656;font-size:15px;}.replyIcon{border-left:4px solid #33ab01;margin-right:5px;}.ad{text-decoration:none;color:#d6d4d4;font-size:12px;}.msgBodyReply{padding-top:5px;}.userName span{float:right;color:#afafaf;font-size:14px;}code{text-align:left;font-size:14px;display:block;white-space:pre;display:-webkit-box;display:-webkit-flex;display:flex;position:relative;}.code-snippet__fix{font-size:14px;margin:10px 0;display:block;color:#333;position:relative;background-color:rgba(0,0,0,0.03);border:1px solid #f0f0f0;border-radius:2px;display:-webkit-box;display:-webkit-flex;display:flex;padding-left:25px;line-height:26px}.code-snippet__fix code{text-align:left;font-size:14px;display:block;white-space:pre;display:-webkit-box;display:-webkit-flex;display:flex;position:relative;font-family:Consolas,\"Liberation Mono\",Menlo,Courier,monospace}.code-snippet__comment,.code-snippet__quote{color:#afafaf;font-style:italic}.code-snippet__keyword,.code-snippet__selector-tag,.code-snippet__subst{color:#ca7d37}.code-snippet__number,.code-snippet__literal,.code-snippet__variable,.code-snippet__template-variable,.code-snippet__tag .code-snippet__attr{color:#0e9ce5}.code-snippet__string,.code-snippet__doctag{color:#d14}.code-snippet__title,.code-snippet__section,.code-snippet__selector-id{color:#d14}.code-snippet__subst{font-weight:normal}.code-snippet__type,.code-snippet__class .code-snippet__title{color:#0e9ce5}.code-snippet__tag,.code-snippet__name,.code-snippet__attribute{color:#0e9ce5;font-weight:normal}.code-snippet__regexp,.code-snippet__link{color:#ca7d37}.code-snippet__symbol,.code-snippet__bullet{color:#d14}.code-snippet__built_in,.code-snippet__builtin-name{color:#ca7d37}.code-snippet__meta{color:#afafaf}.code-snippet__deletion{background:#fdd}.code-snippet__addition{background:#dfd}.code-snippet__emphasis{font-style:italic}.code-snippet__strong{font-weight:bold}.account_avatar{width:40px;height:40px;padding:0;}.account_info{display:-webkit-box;display:-webkit-flex;display:flex;-webkit-box-align:center;-webkit-align-items:center;padding:20px 0;align-items:center}.flex_bd{padding-left:14px;}.account_nickname{display:inline-block;vertical-align:middle;line-height:1.2;color:#576b95;font-size:14px}.account_desc{overflow:hidden;text-overflow:ellipsis;display:-webkit-box;-webkit-box-orient:vertical;-webkit-line-clamp:1;color:rgba(0,0,0,0.3);font-size:14px;line-height:1.2;padding-top:.4em}.msg_source_url{text-align:left;word-break:break-all;margin-top:20px;}.msg_source_url a{padding-right:10px;}.msg_source_url .url_text{color:#a8a8a8;}.video-desc{font-size:14px;margin-top:15px;color:#6c6c6c;}.msg_source_url{text-align:left;}.original_primary_card_tips{color:rgba(0,0,0,0.3);line-height:1.4;font-size:15px;}.weui-flex__item{margin-bottom:20px;padding:20px 16px;margin-top:16px;line-height:1.4;align-items:center;background-color:#f7f7f7;border-radius:8px;position:relative;}.original_primary_desc{color:rgba(0,0,0,0.5);font-size:14px;padding-top:4px;width:auto;overflow:hidden;text-overflow:ellipsis;}.msgBodyReplyList{border-top:1px solid #e1e1e1;margin-top:10px;}.msgBodyReplyListTop{border-top:0;}.reply_like_num{float:right;font-size:14px;color:#c7c7c7;}.msgData{margin-top:20px;color:#626262;}.msgData span{font-size:14px;padding-right:15px;}.msgData .likes{float:right;padding-right:0;}.js_text_content p{font-size:18px;}.rich_media_meta_link{font-size:15px;}blockquote {padding-left: 10px;border-left: 3px solid #dbdbdb;color: rgba(0,0,0,0.5);font-size: 15px;padding-top: 4px;margin: 1em 0;}.video_iframe{width:500px;height:400px;}.blockquote_info{color:#b5b5b5;margin-top:10px;}#copyright_logo{color:#bdbdbd;}.rich_media_meta_list{margin-bottom:10px;}.reprint{background:#efefef;border-radius:5px;padding:8px;color:#1f1f1f;}.reprint a{word-break:break-all;}.topic{color:#8e8e8e;background:#f7f7f7;border-radius:5px;padding:10px 8px;}.topic a{padding-right:5px;}.topic p{margin-bottom:5px;}\n<\/style>\n<link href=\"https:\/\/www.juyifx.cn\/config\/css\/wxArticle.css\" rel=\"stylesheet\"\/>\n<\/head><script>\nvar 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weui-wa-hotarea\" id=\"js_name\">\u751f\u4fe1\u679c <\/a><\/span>2023-11-26 19:01:16<\/em><\/div>\n<content><\/p>\n<div class=\"topic\">\n\u6536\u5f55\u4e8e\u8bdd\u9898<\/p>\n<a href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?__biz=Mzg3OTg3MjQyNg==&action=getalbum&album_id=2812010014583390210#wechat_redirect\" title=\"R\u4ee3\u7801\" target=\"_blank\" rel=\"noopener\">#R\u4ee3\u7801<\/a><a href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?__biz=Mzg3OTg3MjQyNg==&action=getalbum&album_id=2821072943068839938#wechat_redirect\" title=\"\u751f\u4fe1\u7ed8\u56fe\" target=\"_blank\" rel=\"noopener\">#\u751f\u4fe1\u7ed8\u56fe<\/a><a href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?__biz=Mzg3OTg3MjQyNg==&action=getalbum&album_id=2664545260517294084#wechat_redirect\" title=\"\u751f\u4fe1\u5b9e\u64cd\" target=\"_blank\" rel=\"noopener\">#\u751f\u4fe1\u5b9e\u64cd<\/a><\/p>\n<\/div>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.23333333333333334\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_rE2v0O5WiaUDJjgv5bxK2G1ePHyH2g-24.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAysHY49vPGCraibakiaNq6hQgn8C5MfvVLQGxlNZPEia2PajKAzrE2v0O5WiaUDJjgv5bxK2G1ePHyH2g\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" style=\"\" \/><\/p>\n\u5c0f\u679c\u77e5\u8bc6\u5927\u8bb2\u5802\u53c8\u6765\u5566\uff01\u4eca\u5929\u5c0f\u679c\u4e3a\u5927\u5bb6\u5e26\u6765\u7684\u5206\u4eab\u5185\u5bb9\u4e3a\u5229\u7528CMAP\u6570\u636e\u5e93\u8fdb\u884c\u80bf\u7624\u836f\u7269\u9884\u6d4b\uff0c\u5982\u4f55\u8fdb\u884c\u76f8\u5173\u80bf\u7624\u836f\u7269\u9884\u6d4b\uff1f\u4e0d\u614c\uff01\u5c0f\u679c\u6765\u4e3a\u5c0f\u4f19\u4f34\u4eec\u8fdb\u884c\u89e3\u7b54\uff0cCMAP\u5206\u6790\u4e3b\u8981\u5305\u542b\u4ee5\u4e0b\u4e09\u4e2a\u90e8\u5206\uff1a<\/span><\/p>\n\u4e00\u662f\u75be\u75c5\u7684\u5206\u5b50\u7279\u5f81\uff08disease signature\uff09\uff1a\u4ee5\u80bf\u7624\u4e3a\u4f8b\uff0c\u8fd9\u4e2asignature\u53ef\u4ee5\u901a\u8fc7\u5e38\u89c4\u7684\u764c\u4e0e\u764c\u65c1\u7684\u5dee\u5f02\u5206\u6790\u5f97\u5230\u3002<\/span><\/p>\n\u4e8c\u662f\u836f\u7269\u7684\u5206\u5b50\u7279\u5f81\uff08druf signature\uff09\uff1a\u8fd9\u90e8\u5206\u6570\u636e\u53ef\u4ee5\u6765\u81ea\u5927\u5bb6\u719f\u6089CMap\u6570\u636e\u5e93\uff08\u5305\u62ec\u4e861309\u79cd\u836f\u7269\u57285\u4e2a\u7ec6\u80de\u7cfb\u4e2d\u7684\u836f\u7269\u5904\u7406\u540e\u7684\u8868\u8fbe\u7279\u5f81\uff09\u3002<\/span><\/p>\n\u4e09\u662f\u7279\u5f81\u5339\u914d\u7b97\u6cd5\uff08signature matching methods\uff09\uff1a\u5927\u5bb6\u5e38\u7528\u7684\u7f51\u9875\u7248\u7684CMap\u901a\u5e38\u4f7f\u7528\u57fa\u4e8eKolmogorov-Smirnov (KS)\u7684\u65b9\u6cd5\u6765\u8ba1\u7b97CMap score\u3002<\/span><\/p>\n\u901a\u8fc7\u8fd9\u4e09\u4e2a\u90e8\u5206\u5c31\u53ef\u4ee5\u5b8c\u6210\u76f8\u5173\u80bf\u7624\u7684\u836f\u7269\u9884\u6d4b\uff0c\u8fd9\u5c31\u662f\u5c0f\u679c\u4eca\u5929\u5e26\u6765\u7684\u5206\u4eab\u5185\u5bb9\uff0c\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u53ef\u4ee5\u8ddf\u7740\u5c0f\u679c\u5f00\u59cb\u4eca\u5929\u7684\u5b9e\u64cd\u5b66\u4e60\u3002<\/span><\/span><\/p>\n1.<\/span>\u51c6\u5907\u9700\u8981\u7684R\u5305<\/span><\/span><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"sql\"><code>#\u5b89\u88c5\u9700\u8981\u7684R\u5305<\/span><\/span><\/code><code>install.packages(\"stringr\"<\/span>)<\/span><\/code><code>install.packages(\"ggrepel\"<\/span>)<\/span><\/code><code>install.packages(\"ggplot2\"<\/span>)<\/span><\/code><code>install.packages(\"ggthemes\"<\/span>)<\/span><\/code><code>install.packages(\"tidyverse\"<\/span>)<\/span><\/code><code>install.packages(\"dplyr\"<\/span>)<\/span><\/code><code>#\u52a0\u8f7d\u9700\u8981\u7684R\u5305<\/span><\/span><\/code><code>library<\/span>(parallel<\/span>)<\/span><\/code><code>library<\/span>(dplyr)<\/span><\/code><code>library<\/span>(stringr)<\/span><\/code><code>library<\/span>(tidyverse)<\/span><\/code><code>library<\/span>(tibble)<\/span><\/code><code>library<\/span>(clusterProfiler)<\/span><\/code><code>library<\/span>(ggplot2) <\/span><\/code><code>library<\/span>(ggrepel)<\/span><\/code><code>library<\/span>(ggthemes)<\/span><\/code><code>library<\/span>(gridExtra)<\/span><\/code><\/pre>\n<\/section>\n2.<\/span>\u6570\u636e\u8bfb\u53d6\u4e0e\u5904\u7406<\/span><\/span><\/p>\n#LIHC_TPM.txt\uff0c\u57fa\u56e0\u8868\u8fbe\u77e9\u9635\u6587\u4ef6\uff0c\u7b2c\u4e00\u5217\u4e3a\u57fa\u56e0\u540d\uff0c\u5176\u4ed6\u5217\u4e3a\u6837\u672c\u540d<\/span><\/p>\ndata <- read.table(“LIHC_TPM.txt”, sep=”t”, check.names=F, header=T, row.names=1)<\/span><\/p>\n<img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-ratio=\"0.25277777777777777\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-11-26_\u300c\u4ed8\u8d39\u300d\u3010\u4ee3\u7801\u5206\u4eab-15\u30118+\u80bf\u7624\u751f\u4fe1\u6587\u7ae0\u7684\u5ba0\u513f-CMAP\u80bf\u7624\u836f\u7269\u9884\u6d4b\u5206\u6790\/2_iaME2weqY7cGvU0QrTVQQ9VE68Vl9A.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAy9o4ZfUgVysEzia9ic710OTf78eCq7phmS5ARicQJ5IeRZvyYqiaME2weqY7cGvU0QrTVQQ9VE68Vl9A\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" height=\"139.739990234375\" width=\"553.010009765625\" \/><\/span><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"bash\"><code># \u5f97\u5230\u764c\u4e0e\u764c\u65c1\u6bd4\u8f83\u7684logfc<\/span><\/span><\/code><code>tumor <- data[, str_detect(colnames(data), \"-01\"<\/span>)]<\/span><\/code><code>normal <- data[, str_detect(colnames(data), \"-11\"<\/span>)]<\/span><\/code><code>dis_sig <- data.frame(id=rownames(data),<\/span><\/code><code> fc<\/span>=log2(rowMeans(tumor)\/rowMeans(normal)))<\/span><\/code><code>dis_sig <- dis_sig[dis_sig$fc<\/span> != \"Inf\"<\/span> & dis_sig$fc<\/span> != \"-Inf\"<\/span>,]<\/span><\/code><code>dis_sig <- na.omit(dis_sig)<\/span><\/code><code>dis_sig <- rbind(top_n(dis_sig, 150, fc<\/span>), top_n(dis_sig, -150, fc<\/span>))<\/span><\/code><code># \u5c06logfc\u8f6c\u6210\u4e8c\u5206\u7c7b\u53d8\u91cf\uff08logfc>0\u7684\u57fa\u56e0\u75281\u8868\u793a\uff0clogfc\u5c0f\u4e8e0\u7684\u57fa\u56e0\u7528-1\u8868\u793a\uff09<\/span><\/span><\/code><code>dis_sig$fc<\/span>[dis_sig$fc<\/span>>0] <- 1; dis_sig$fc<\/span>[dis_sig$fc<\/span><0] <- -1<\/span><\/code><code>rownames(dis_sig) <- NULL<\/span><\/code><code># \u4fdd\u5b58\u7ed3\u679c<\/span><\/span><\/code><code>write.table(dis_sig, \"dis_sig.csv\"<\/span>, sep=\",\"<\/span>, quote=F, row.names=F, col.names=T)<\/span><\/code><code># dis_sig\u53ea\u8981\u6574\u7406\u6210\u4ee5\u4e0b\u683c\u5f0f\u90fd\u53ef\u4ee5\u5728\u540e\u9762\u7684\u5206\u6790\u4e2d\u4f7f\u7528<\/span><\/span><\/code><code>head(dis_sig)<\/span><\/code><\/pre>\n<\/section>\n5.<\/span>\u7ed3\u679c\u56fe\u7247<\/span><\/span><\/p>\n5.1 CMAP_XSum.pdf<\/span><\/p>\n\u8be5\u7ed3\u679c\u56fe\u7247\u4e3a\u7ed8\u5236\u7684CMAP score\u6563\u70b9\u56fe\uff0c\u7a81\u51fa\u663e\u793a\u836f\u7269top5\u7684\u836f\u7269\uff0c\u6807\u51fa\u836f\u7269\u540d;\u8fd9\u91cc\u6211\u4eec\u5f97\u5230\u7684\u5206\u6570\u8d8a\u4f4e\uff0c\u8fd9\u4e2a\u836f\u7269\u8d8a\u6709\u53ef\u80fd\u9006\u8f6c\u75be\u75c5\u7684\u5206\u5b50\u7279\u5f81\uff0c\u7406\u8bba\u4e0a\u66f4\u6709\u53ef\u80fd\u5177\u6709\u6cbb\u7597\u8be5\u75be\u75c5\u7684\u80fd\u529b\u3002\u8be5\u6f14\u793a\u6570\u636e\u7ed3\u679c\u63d0\u793a X4.5.dianilinophthalimide \u662f\u6700\u6709\u53ef\u80fd\u6cbb\u7597\u809d\u764c\u7684\u836f\u7269\u3002<\/span> <\/span><o:page><\/o:page><\/p>\n<img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-ratio=\"1.3896907216494845\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_ic9ibEBf0MY3icCzUKU2Te2HsibHHQ.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAy9o4ZfUgVysEzia9ic710OTfoib6zK5j4ibXTibTKyBQiarJxhYlTV4bic9ibEBf0MY3icCzUKU2Te2HsibHHQ\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"485\" height=\"449.3399658203125\" width=\"323.3399963378906\" \/><\/span><\/p>\n5.2 dis_sig.csv<\/span><\/p>\n\u8be5\u7ed3\u679c\u6587\u4ef6\u4e3a\u901a\u8fc7\u5dee\u5f02\u5206\u6790\u5f97\u5230\u75be\u75c5\u5206\u5b50\u7279\u5f81\uff0c\u7b2c\u4e00\u5217\u4e3a\u57fa\u56e0\u540d\uff0c\u7b2c\u4e8c\u5217\u4e3a\u5206\u7c7b\u7279\u5f81\uff0c\u662fcamp\u5206\u6790\u6700\u7b80\u5355\u7684\u4e00\u79cd\u5e94\u7528\u65b9\u5f0f\uff0c\u5927\u5bb6\u4e5f\u53ef\u4ee5\u5f00\u53d1\u66f4\u591a\u7684\u4f7f\u7528\u65b9\u5f0f\uff08\u5982\u901a\u8fc7\u6bd4\u8f83\u8f6c\u79fb\u4e0e\u975e\u8f6c\u79fb\u7684\u80bf\u7624\u6837\u672c\u5f97\u5230\u4e0e\u8f6c\u79fb\u76f8\u5173\u7684\u5206\u5b50\u7279\u5f81\uff0c\u57fa\u4e8e\u8fd9\u4e2a\u5206\u5b50\u7279\u5f81\u8fdb\u884ccmap\u5206\u6790\u5c31\u6709\u53ef\u80fd\u627e\u5230\u6f5c\u5728\u5bf9\u6297\u8f6c\u79fb\u7684\u836f\u7269\u3002<\/span> <\/span><o:page><\/o:page><\/p>\n<img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-ratio=\"0.5302713987473904\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-11-26_\u300c\u4ed8\u8d39\u300d\u3010\u4ee3\u7801\u5206\u4eab-15\u30118+\u80bf\u7624\u751f\u4fe1\u6587\u7ae0\u7684\u5ba0\u513f-CMAP\u80bf\u7624\u836f\u7269\u9884\u6d4b\u5206\u6790\/4_Qt8ib11Jr3DhEGWdPs1ia5vYpqceJA.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAy9o4ZfUgVysEzia9ic710OTficwg3D5I36xbuZzDvgB1Egx6jfAQt8ib11Jr3DhEGWdPs1ia5vYpqceJA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"958\" height=\"293.6000061035156\" width=\"553.739990234375\" \/><\/span><\/p>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;letter-spacing: 0.578px;white-space: normal;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);text-align: left;\">\n<section style=\"outline: 0px;font-size: 16px;text-indent: 0em;\">\n<section powered-by=\"xiumi.us\" style=\"margin: 10px;outline: 0px;justify-content: flex-start;display: flex;flex-flow: row;\">\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;display: inline-block;width: 558px;vertical-align: top;border-style: dashed;border-width: 1px;border-color: rgb(62, 62, 62);align-self: flex-start;flex: 0 0 auto;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;\">\n<section style=\"outline: 0px;display: inline-block;width: 536px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(144, 215, 236);border-right-color: rgb(46, 172, 109);box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-bottom-left-radius: 0px;\">\n<section powered-by=\"xiumi.us\" style=\"padding-right: 3px;padding-left: 3px;outline: 0px;\">\n<section style=\"margin-top: 0.95em;margin-bottom: -0.65em;outline: 0px;display: inline-block;width: 520px;vertical-align: top;\">\n<section style=\"margin-top: -1em;padding: 3px 10px;outline: 0px;display: inline-block;vertical-align: top;color: rgb(0, 154, 68);\">\n\u5f80\u671f\u63a8\u8350<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;text-align: justify;\">\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491794&idx=1&sn=2b7a4de95169c79202e44813885a8250&chksm=cf7f7017f808f9015689839fe4057fd418bf7b20eb1dfb5a28cd92e56a41b5605e62bfbc16fb&scene=21#wechat_redirect\" textvalue=\"1.\u642d\u5efa\u751f\u4fe1\u5206\u6790\u6d41\u6c34\u7ebf\uff0c\u5982\u5de5\u5382\u4e00\u683724\u5c0f\u65f6\u8fd0\u8f6cSnakemake\u2014\u2014\u8fdb\u9636\u547d\u4ee4\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;font-size: 15px;\" rel=\"noopener\">1.\u642d\u5efa\u751f\u4fe1\u5206\u6790\u6d41\u6c34\u7ebf\uff0c\u5982\u5de5\u5382\u4e00\u683724\u5c0f\u65f6\u8fd0\u8f6cSnakemake\u2014\u2014\u8fdb\u9636\u547d\u4ee4<\/a> <\/section>\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491705&idx=1&sn=9ff9b6da28b3a256a99c6697d589be66&chksm=cf7f70bcf808f9aafd1019a0bba3dd3a55e2867dbb9a09203f13c2683adf867094637c405ed1&scene=21#wechat_redirect\" textvalue=\"2.\u6bd4blast\u8fd8\u4f18\u79c0\u7684\u5e8f\u5217\u6bd4\u5bf9\u5de5\u5177\uff1fHMMER\u6765\u4e86\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;font-size: 15px;\" rel=\"noopener\">2.\u6bd4blast\u8fd8\u4f18\u79c0\u7684\u5e8f\u5217\u6bd4\u5bf9\u5de5\u5177\uff1fHMMER\u6765\u4e86<\/a><\/section>\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491909&idx=1&sn=902e34bcf53e605fba2b457ec6a33e36&chksm=cf7f7180f808f8961542f458a49da14e85d8831449fb65fbf2623d55affc564686a5422f56fd&scene=21#wechat_redirect\" textvalue=\"3.\u5bf9\u5355\u7ec6\u80de\u5206\u6790\u6beb\u65e0\u5934\u7eea\uff1f\u8ba9popsicleR\u9886\u4f60\u5165\u95e8\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;font-size: 15px;\" rel=\"noopener\">3.\u5bf9\u5355\u7ec6\u80de\u5206\u6790\u6beb\u65e0\u5934\u7eea\uff1f\u8ba9popsicleR\u9886\u4f60\u5165\u95e8<\/a><\/section>\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491905&idx=1&sn=fb34ebd6282962c7803badaee7a39096&chksm=cf7f7184f808f8929608c0050344ad86193d0fc6455c1c18e16cc17bf4b37832b63d3b18284e&scene=21#wechat_redirect\" textvalue=\"4.\u5c0f\u679c\u5e26\u4f60\u7ed8\u5236ROC\u66f2\u7ebf\u8bc4\u4f30\u751f\u5b58\u9884\u6d4b\u80fd\u529b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);cursor: pointer;outline: 0px;font-size: 15px;\" rel=\"noopener\">4.\u5c0f\u679c\u5e26\u4f60\u7ed8\u5236ROC\u66f2\u7ebf\u8bc4\u4f30\u751f\u5b58\u9884\u6d4b\u80fd\u529b<\/a><\/section>\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247493633&idx=1&sn=2263dfe7572c0bcf6816c2c1a37d79de&chksm=cf7f78c4f808f1d2209321d6ace39fde5fa60c0691b56f88eac21916f5a2872ce8ee345f1d5f&scene=21#wechat_redirect\" textvalue=\"\u8f6f\u4ef6\u5305\u5b89\u88c5\u3001\u6253\u602a\u5feb\u53c8\u597d\uff0c1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff1b\u8fd8\u6709\u6bd4\u8fd9\u66f4\u7701\u94b1\u7684\u561b\uff01\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;letter-spacing: 0.578px;font-size: 15px;\" rel=\"noopener\">5.\u8f6f\u4ef6\u5305\u5b89\u88c5\u3001\u6253\u602a\u5feb\u53c8\u597d\uff0c1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff1b\u8fd8\u6709\u6bd4\u8fd9\u66f4\u7701\u94b1\u7684\u561b\uff01\uff01\uff01<\/a><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;letter-spacing: 0.578px;text-indent: 0em;white-space: normal;text-align: left;line-height: normal;font-size: 12pt;font-family: helvetica;color: rgb(0, 0, 0);break-after: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.38981481481481484\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_FbEg9fibwQicL8l2ExKOZZTmAHXabQ-4.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAx3HetBkB7aOGibFWKqibqIATyC4zFibzCgdrxFwRep6cDMLIbA0FbEg9fibwQicL8l2ExKOZZTmAHXabQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"font-size: var(--articleFontsize);letter-spacing: 0.034em;caret-color: rgba(0, 0, 0, 0);\" \/><\/section>\n<section style=\"margin-bottom: 0px;letter-spacing: 0.578px;text-indent: 0em;white-space: normal;font-size: 16px;\">\u5982\u679c\u9700\u8981\u5b8c\u6574\u7684\u4ee3\u7801\u53ef\u4ee5\u70b9\u51fb\u4ed8\u8d39\u83b7\u53d6\u54e6!\u4eca\u5929\u5c0f\u679c\u7684\u5206\u4eab\u5c31\u5230\u8fd9\u91cc\uff0c\u5982\u679c\u5c0f\u4f19\u4f34\u6709\u5176\u4ed6\u6570\u636e\u5206\u6790\u9700\u6c42\uff0c\u53ef\u4ee5\u5c1d\u8bd5\u672c\u516c\u53f8\u65b0\u5f00\u53d1\u7684\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u4e91\u5e73\u53f0\uff0c\u5b63\u4ee3\u7801\u5b8c\u6210\u5206\u6790\uff0c\u975e\u5e38\u65b9\u4fbf\u5965!<\/span><\/section>\n<mp-pay-preview-filter data-offset=\"23\"><\/mp-pay-preview-filter><\/p>\n<\/content>\n<\/div>\n<\/body> \n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"\u300c\u4ed8\u8d39\u300d\u3010\u4ee3\u7801\u5206\u4eab-15\u30118+\u80bf\u7624\u751f\u4fe1\u6587\u7ae0\u7684\u5ba0\u513f-CMAP\u80bf\u7624\u836f\u7269\u9884\u6d4b\u5206\u6790 \u539f\u521b \u5c0f\u679c& […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/54577"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=54577"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/54577\/revisions"}],"predecessor-version":[{"id":54585,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/54577\/revisions\/54585"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=54577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=54577"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=54577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

{"id":54577,"date":"2024-06-16T14:19:44","date_gmt":"2024-06-16T06:19:44","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=54577"},"modified":"2024-06-16T14:19:44","modified_gmt":"2024-06-16T06:19:44","slug":"%e3%80%8c%e4%bb%98%e8%b4%b9%e3%80%8d%e3%80%90%e4%bb%a3%e7%a0%81%e5%88%86%e4%ba%ab-15%e3%80%918%e8%82%bf%e7%98%a4%e7%94%9f%e4%bf%a1%e6%96%87%e7%ab%a0%e7%9a%84%e5%ae%a0%e5%84%bf-cmap%e8%82%bf%e7%98%a4-2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=54577","title":{"rendered":"\u300c\u4ed8\u8d39\u300d\u3010\u4ee3\u7801\u5206\u4eab-15\u30118+\u80bf\u7624\u751f\u4fe1\u6587\u7ae0\u7684\u5ba0\u513f-CMAP\u80bf\u7624\u836f\u7269\u9884\u6d4b\u5206\u6790"},"content":{"rendered":"

\n
\n<\/title> \n<meta charset=\"utf-8\"> \n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,maximum-scale=1.0,user-scalable=0,viewport-fit=cover\"><\/p>\n<style>\n*{margin:0;padding:0}html{-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;line-height:1.6}img{z-index:999;position:relative;max-width:100%;margin:10px 0;}body{letter-spacing:.034em}h1,h2,h3,h4,h5,h6{font-weight:400;font-size:16px}a{color:#576b95;text-decoration:none;-webkit-tap-highlight-color:rgba(0,0,0,0)}td,th{word-wrap:break-word;padding:5px 10px;border:1px solid #DDD;}table{margin-bottom:10px;border-collapse:collapse;display:table;width:100%!important;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}.rich_media_area_primary{padding:20px 16px 12px;background-color:#fafafa}@media (max-width:375px){.rich_media_area_primary{padding:20px 60px 15px 60px}.rich_media_area_extra{padding:0 60px 21px 60px}}@media (min-width:1024px){.rich_media_area_primary_inner,.rich_media_area_extra_inner,body{max-width:677px;margin-left:auto;margin-right:auto}.rich_media_area_primary{padding-top:32px}}.rich_media{padding:20px;overflow:hidden;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}@media screen and (min-width:1024px){.rich_media_area_primary_inner,.rich_media_area_extra_inner{max-width:677px;margin-left:auto;margin-right:auto}.rich_media_area_primary{padding-top:32px}}.rich_media_content{overflow:hidden;color:#333;font-size:17px;word-wrap:break-word;-webkit-hyphens:auto;-ms-hyphens:auto;hyphens:auto;text-align:justify;position:relative;z-index:0}.rich_media_content *{max-width:100%!important;box-sizing:border-box!important;-webkit-box-sizing:border-box!important;word-wrap:break-word!important}.rich_media_content p{clear:both;min-height:1em}.rich_media_content em{font-style:italic}.rich_media_content fieldset{min-width:0}.rich_media_content .list-paddingleft-1,.rich_media_content .list-paddingleft-2,.rich_media_content .list-paddingleft-3{padding-left:2.2em}.rich_media_content .list-paddingleft-1 .list-paddingleft-2,.rich_media_content .list-paddingleft-2 .list-paddingleft-2,.rich_media_content .list-paddingleft-3 .list-paddingleft-2{padding-left:30px}.rich_media_content .list-paddingleft-1{padding-left:1.2em}.rich_media_content .list-paddingleft-3{padding-left:3.2em}.rich_media_content .code-snippet,.rich_media_content .code-snippet__fix{max-width:1000%!important}.rich_media_content .code-snippet *,.rich_media_content .code-snippet__fix *{max-width:1000%!important}.rich_media_title{font-size:22px;line-height:1.4;margin-bottom:13px;padding-bottom:13px;border-bottom:1px solid #e7e7eb;}@supports(-webkit-overflow-scrolling:touch){.rich_media_title{font-weight:700}}.rich_media_meta{display:inline-block;vertical-align:middle;padding:0 0 10px 0;font-size:15px;-webkit-tap-highlight-color:rgba(0,0,0,0)}.rich_media_meta.icon_appmsg_tag{margin-right:0px}.rich_media_meta.meta_tag_text{margin-right:0}.rich_media_meta_list em{font-style:normal}.rich_media_meta_text{color:#a5a5a5;}p{margin:0;}.msgBox{margin-top:20px;padding-top:20px;padding-left:50px;overflow:hidden;border-top:2px dashed #09a2ff;}.msg{padding-top:7px;clear:both;}.msgBody{float:right;width:100%;margin-left:55px;padding-bottom:15px;border-bottom:1px dashed #e0e0e0;}.userHeadImg{float:left;margin-left:-50px;}.userHeadImg img{width:40px;height:40px;margin-right:10px;border-radius:3px;}.userName{color:#888888;line-height:24px;font-size:14px;margin:5px 0 5px 0;height:24px;}.replyBody,.autherBody{color:#565656;font-size:15px;}.replyIcon{border-left:4px solid #33ab01;margin-right:5px;}.ad{text-decoration:none;color:#d6d4d4;font-size:12px;}.msgBodyReply{padding-top:5px;}.userName span{float:right;color:#afafaf;font-size:14px;}code{text-align:left;font-size:14px;display:block;white-space:pre;display:-webkit-box;display:-webkit-flex;display:flex;position:relative;}.code-snippet__fix{font-size:14px;margin:10px 0;display:block;color:#333;position:relative;background-color:rgba(0,0,0,0.03);border:1px solid #f0f0f0;border-radius:2px;display:-webkit-box;display:-webkit-flex;display:flex;padding-left:25px;line-height:26px}.code-snippet__fix code{text-align:left;font-size:14px;display:block;white-space:pre;display:-webkit-box;display:-webkit-flex;display:flex;position:relative;font-family:Consolas,\"Liberation Mono\",Menlo,Courier,monospace}.code-snippet__comment,.code-snippet__quote{color:#afafaf;font-style:italic}.code-snippet__keyword,.code-snippet__selector-tag,.code-snippet__subst{color:#ca7d37}.code-snippet__number,.code-snippet__literal,.code-snippet__variable,.code-snippet__template-variable,.code-snippet__tag .code-snippet__attr{color:#0e9ce5}.code-snippet__string,.code-snippet__doctag{color:#d14}.code-snippet__title,.code-snippet__section,.code-snippet__selector-id{color:#d14}.code-snippet__subst{font-weight:normal}.code-snippet__type,.code-snippet__class .code-snippet__title{color:#0e9ce5}.code-snippet__tag,.code-snippet__name,.code-snippet__attribute{color:#0e9ce5;font-weight:normal}.code-snippet__regexp,.code-snippet__link{color:#ca7d37}.code-snippet__symbol,.code-snippet__bullet{color:#d14}.code-snippet__built_in,.code-snippet__builtin-name{color:#ca7d37}.code-snippet__meta{color:#afafaf}.code-snippet__deletion{background:#fdd}.code-snippet__addition{background:#dfd}.code-snippet__emphasis{font-style:italic}.code-snippet__strong{font-weight:bold}.account_avatar{width:40px;height:40px;padding:0;}.account_info{display:-webkit-box;display:-webkit-flex;display:flex;-webkit-box-align:center;-webkit-align-items:center;padding:20px 0;align-items:center}.flex_bd{padding-left:14px;}.account_nickname{display:inline-block;vertical-align:middle;line-height:1.2;color:#576b95;font-size:14px}.account_desc{overflow:hidden;text-overflow:ellipsis;display:-webkit-box;-webkit-box-orient:vertical;-webkit-line-clamp:1;color:rgba(0,0,0,0.3);font-size:14px;line-height:1.2;padding-top:.4em}.msg_source_url{text-align:left;word-break:break-all;margin-top:20px;}.msg_source_url a{padding-right:10px;}.msg_source_url .url_text{color:#a8a8a8;}.video-desc{font-size:14px;margin-top:15px;color:#6c6c6c;}.msg_source_url{text-align:left;}.original_primary_card_tips{color:rgba(0,0,0,0.3);line-height:1.4;font-size:15px;}.weui-flex__item{margin-bottom:20px;padding:20px 16px;margin-top:16px;line-height:1.4;align-items:center;background-color:#f7f7f7;border-radius:8px;position:relative;}.original_primary_desc{color:rgba(0,0,0,0.5);font-size:14px;padding-top:4px;width:auto;overflow:hidden;text-overflow:ellipsis;}.msgBodyReplyList{border-top:1px solid #e1e1e1;margin-top:10px;}.msgBodyReplyListTop{border-top:0;}.reply_like_num{float:right;font-size:14px;color:#c7c7c7;}.msgData{margin-top:20px;color:#626262;}.msgData span{font-size:14px;padding-right:15px;}.msgData .likes{float:right;padding-right:0;}.js_text_content p{font-size:18px;}.rich_media_meta_link{font-size:15px;}blockquote {padding-left: 10px;border-left: 3px solid #dbdbdb;color: rgba(0,0,0,0.5);font-size: 15px;padding-top: 4px;margin: 1em 0;}.video_iframe{width:500px;height:400px;}.blockquote_info{color:#b5b5b5;margin-top:10px;}#copyright_logo{color:#bdbdbd;}.rich_media_meta_list{margin-bottom:10px;}.reprint{background:#efefef;border-radius:5px;padding:8px;color:#1f1f1f;}.reprint a{word-break:break-all;}.topic{color:#8e8e8e;background:#f7f7f7;border-radius:5px;padding:10px 8px;}.topic a{padding-right:5px;}.topic p{margin-bottom:5px;}\n<\/style>\n<link href=\"https:\/\/www.juyifx.cn\/config\/css\/wxArticle.css\" rel=\"stylesheet\"\/>\n<\/head><script>\nvar 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weui-wa-hotarea\" id=\"js_name\">\u751f\u4fe1\u679c <\/a><\/span>2023-11-26 19:01:16<\/em><\/div>\n<content><\/p>\n<div class=\"topic\">\n\u6536\u5f55\u4e8e\u8bdd\u9898<\/p>\n<a href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?__biz=Mzg3OTg3MjQyNg==&action=getalbum&album_id=2812010014583390210#wechat_redirect\" title=\"R\u4ee3\u7801\" target=\"_blank\" rel=\"noopener\">#R\u4ee3\u7801<\/a><a href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?__biz=Mzg3OTg3MjQyNg==&action=getalbum&album_id=2821072943068839938#wechat_redirect\" title=\"\u751f\u4fe1\u7ed8\u56fe\" target=\"_blank\" rel=\"noopener\">#\u751f\u4fe1\u7ed8\u56fe<\/a><a href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?__biz=Mzg3OTg3MjQyNg==&action=getalbum&album_id=2664545260517294084#wechat_redirect\" title=\"\u751f\u4fe1\u5b9e\u64cd\" target=\"_blank\" rel=\"noopener\">#\u751f\u4fe1\u5b9e\u64cd<\/a><\/p>\n<\/div>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.23333333333333334\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_rE2v0O5WiaUDJjgv5bxK2G1ePHyH2g-24.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAysHY49vPGCraibakiaNq6hQgn8C5MfvVLQGxlNZPEia2PajKAzrE2v0O5WiaUDJjgv5bxK2G1ePHyH2g\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" style=\"\" \/><\/p>\n\u5c0f\u679c\u77e5\u8bc6\u5927\u8bb2\u5802\u53c8\u6765\u5566\uff01\u4eca\u5929\u5c0f\u679c\u4e3a\u5927\u5bb6\u5e26\u6765\u7684\u5206\u4eab\u5185\u5bb9\u4e3a\u5229\u7528CMAP\u6570\u636e\u5e93\u8fdb\u884c\u80bf\u7624\u836f\u7269\u9884\u6d4b\uff0c\u5982\u4f55\u8fdb\u884c\u76f8\u5173\u80bf\u7624\u836f\u7269\u9884\u6d4b\uff1f\u4e0d\u614c\uff01\u5c0f\u679c\u6765\u4e3a\u5c0f\u4f19\u4f34\u4eec\u8fdb\u884c\u89e3\u7b54\uff0cCMAP\u5206\u6790\u4e3b\u8981\u5305\u542b\u4ee5\u4e0b\u4e09\u4e2a\u90e8\u5206\uff1a<\/span><\/p>\n\u4e00\u662f\u75be\u75c5\u7684\u5206\u5b50\u7279\u5f81\uff08disease signature\uff09\uff1a\u4ee5\u80bf\u7624\u4e3a\u4f8b\uff0c\u8fd9\u4e2asignature\u53ef\u4ee5\u901a\u8fc7\u5e38\u89c4\u7684\u764c\u4e0e\u764c\u65c1\u7684\u5dee\u5f02\u5206\u6790\u5f97\u5230\u3002<\/span><\/p>\n\u4e8c\u662f\u836f\u7269\u7684\u5206\u5b50\u7279\u5f81\uff08druf signature\uff09\uff1a\u8fd9\u90e8\u5206\u6570\u636e\u53ef\u4ee5\u6765\u81ea\u5927\u5bb6\u719f\u6089CMap\u6570\u636e\u5e93\uff08\u5305\u62ec\u4e861309\u79cd\u836f\u7269\u57285\u4e2a\u7ec6\u80de\u7cfb\u4e2d\u7684\u836f\u7269\u5904\u7406\u540e\u7684\u8868\u8fbe\u7279\u5f81\uff09\u3002<\/span><\/p>\n\u4e09\u662f\u7279\u5f81\u5339\u914d\u7b97\u6cd5\uff08signature matching methods\uff09\uff1a\u5927\u5bb6\u5e38\u7528\u7684\u7f51\u9875\u7248\u7684CMap\u901a\u5e38\u4f7f\u7528\u57fa\u4e8eKolmogorov-Smirnov (KS)\u7684\u65b9\u6cd5\u6765\u8ba1\u7b97CMap score\u3002<\/span><\/p>\n\u901a\u8fc7\u8fd9\u4e09\u4e2a\u90e8\u5206\u5c31\u53ef\u4ee5\u5b8c\u6210\u76f8\u5173\u80bf\u7624\u7684\u836f\u7269\u9884\u6d4b\uff0c\u8fd9\u5c31\u662f\u5c0f\u679c\u4eca\u5929\u5e26\u6765\u7684\u5206\u4eab\u5185\u5bb9\uff0c\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u53ef\u4ee5\u8ddf\u7740\u5c0f\u679c\u5f00\u59cb\u4eca\u5929\u7684\u5b9e\u64cd\u5b66\u4e60\u3002<\/span><\/span><\/p>\n1.<\/span>\u51c6\u5907\u9700\u8981\u7684R\u5305<\/span><\/span><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"sql\"><code>#\u5b89\u88c5\u9700\u8981\u7684R\u5305<\/span><\/span><\/code><code>install.packages(\"stringr\"<\/span>)<\/span><\/code><code>install.packages(\"ggrepel\"<\/span>)<\/span><\/code><code>install.packages(\"ggplot2\"<\/span>)<\/span><\/code><code>install.packages(\"ggthemes\"<\/span>)<\/span><\/code><code>install.packages(\"tidyverse\"<\/span>)<\/span><\/code><code>install.packages(\"dplyr\"<\/span>)<\/span><\/code><code>#\u52a0\u8f7d\u9700\u8981\u7684R\u5305<\/span><\/span><\/code><code>library<\/span>(parallel<\/span>)<\/span><\/code><code>library<\/span>(dplyr)<\/span><\/code><code>library<\/span>(stringr)<\/span><\/code><code>library<\/span>(tidyverse)<\/span><\/code><code>library<\/span>(tibble)<\/span><\/code><code>library<\/span>(clusterProfiler)<\/span><\/code><code>library<\/span>(ggplot2) <\/span><\/code><code>library<\/span>(ggrepel)<\/span><\/code><code>library<\/span>(ggthemes)<\/span><\/code><code>library<\/span>(gridExtra)<\/span><\/code><\/pre>\n<\/section>\n2.<\/span>\u6570\u636e\u8bfb\u53d6\u4e0e\u5904\u7406<\/span><\/span><\/p>\n#LIHC_TPM.txt\uff0c\u57fa\u56e0\u8868\u8fbe\u77e9\u9635\u6587\u4ef6\uff0c\u7b2c\u4e00\u5217\u4e3a\u57fa\u56e0\u540d\uff0c\u5176\u4ed6\u5217\u4e3a\u6837\u672c\u540d<\/span><\/p>\ndata <- read.table(“LIHC_TPM.txt”, sep=”t”, check.names=F, header=T, row.names=1)<\/span><\/p>\n<img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-ratio=\"0.25277777777777777\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-11-26_\u300c\u4ed8\u8d39\u300d\u3010\u4ee3\u7801\u5206\u4eab-15\u30118+\u80bf\u7624\u751f\u4fe1\u6587\u7ae0\u7684\u5ba0\u513f-CMAP\u80bf\u7624\u836f\u7269\u9884\u6d4b\u5206\u6790\/2_iaME2weqY7cGvU0QrTVQQ9VE68Vl9A.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAy9o4ZfUgVysEzia9ic710OTf78eCq7phmS5ARicQJ5IeRZvyYqiaME2weqY7cGvU0QrTVQQ9VE68Vl9A\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" height=\"139.739990234375\" width=\"553.010009765625\" \/><\/span><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"bash\"><code># \u5f97\u5230\u764c\u4e0e\u764c\u65c1\u6bd4\u8f83\u7684logfc<\/span><\/span><\/code><code>tumor <- data[, str_detect(colnames(data), \"-01\"<\/span>)]<\/span><\/code><code>normal <- data[, str_detect(colnames(data), \"-11\"<\/span>)]<\/span><\/code><code>dis_sig <- data.frame(id=rownames(data),<\/span><\/code><code> fc<\/span>=log2(rowMeans(tumor)\/rowMeans(normal)))<\/span><\/code><code>dis_sig <- dis_sig[dis_sig$fc<\/span> != \"Inf\"<\/span> & dis_sig$fc<\/span> != \"-Inf\"<\/span>,]<\/span><\/code><code>dis_sig <- na.omit(dis_sig)<\/span><\/code><code>dis_sig <- rbind(top_n(dis_sig, 150, fc<\/span>), top_n(dis_sig, -150, fc<\/span>))<\/span><\/code><code># \u5c06logfc\u8f6c\u6210\u4e8c\u5206\u7c7b\u53d8\u91cf\uff08logfc>0\u7684\u57fa\u56e0\u75281\u8868\u793a\uff0clogfc\u5c0f\u4e8e0\u7684\u57fa\u56e0\u7528-1\u8868\u793a\uff09<\/span><\/span><\/code><code>dis_sig$fc<\/span>[dis_sig$fc<\/span>>0] <- 1; dis_sig$fc<\/span>[dis_sig$fc<\/span><0] <- -1<\/span><\/code><code>rownames(dis_sig) <- NULL<\/span><\/code><code># \u4fdd\u5b58\u7ed3\u679c<\/span><\/span><\/code><code>write.table(dis_sig, \"dis_sig.csv\"<\/span>, sep=\",\"<\/span>, quote=F, row.names=F, col.names=T)<\/span><\/code><code># dis_sig\u53ea\u8981\u6574\u7406\u6210\u4ee5\u4e0b\u683c\u5f0f\u90fd\u53ef\u4ee5\u5728\u540e\u9762\u7684\u5206\u6790\u4e2d\u4f7f\u7528<\/span><\/span><\/code><code>head(dis_sig)<\/span><\/code><\/pre>\n<\/section>\n5.<\/span>\u7ed3\u679c\u56fe\u7247<\/span><\/span><\/p>\n5.1 CMAP_XSum.pdf<\/span><\/p>\n\u8be5\u7ed3\u679c\u56fe\u7247\u4e3a\u7ed8\u5236\u7684CMAP score\u6563\u70b9\u56fe\uff0c\u7a81\u51fa\u663e\u793a\u836f\u7269top5\u7684\u836f\u7269\uff0c\u6807\u51fa\u836f\u7269\u540d;\u8fd9\u91cc\u6211\u4eec\u5f97\u5230\u7684\u5206\u6570\u8d8a\u4f4e\uff0c\u8fd9\u4e2a\u836f\u7269\u8d8a\u6709\u53ef\u80fd\u9006\u8f6c\u75be\u75c5\u7684\u5206\u5b50\u7279\u5f81\uff0c\u7406\u8bba\u4e0a\u66f4\u6709\u53ef\u80fd\u5177\u6709\u6cbb\u7597\u8be5\u75be\u75c5\u7684\u80fd\u529b\u3002\u8be5\u6f14\u793a\u6570\u636e\u7ed3\u679c\u63d0\u793a X4.5.dianilinophthalimide \u662f\u6700\u6709\u53ef\u80fd\u6cbb\u7597\u809d\u764c\u7684\u836f\u7269\u3002<\/span> <\/span><o:page><\/o:page><\/p>\n<img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-ratio=\"1.3896907216494845\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_ic9ibEBf0MY3icCzUKU2Te2HsibHHQ.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAy9o4ZfUgVysEzia9ic710OTfoib6zK5j4ibXTibTKyBQiarJxhYlTV4bic9ibEBf0MY3icCzUKU2Te2HsibHHQ\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"485\" height=\"449.3399658203125\" width=\"323.3399963378906\" \/><\/span><\/p>\n5.2 dis_sig.csv<\/span><\/p>\n\u8be5\u7ed3\u679c\u6587\u4ef6\u4e3a\u901a\u8fc7\u5dee\u5f02\u5206\u6790\u5f97\u5230\u75be\u75c5\u5206\u5b50\u7279\u5f81\uff0c\u7b2c\u4e00\u5217\u4e3a\u57fa\u56e0\u540d\uff0c\u7b2c\u4e8c\u5217\u4e3a\u5206\u7c7b\u7279\u5f81\uff0c\u662fcamp\u5206\u6790\u6700\u7b80\u5355\u7684\u4e00\u79cd\u5e94\u7528\u65b9\u5f0f\uff0c\u5927\u5bb6\u4e5f\u53ef\u4ee5\u5f00\u53d1\u66f4\u591a\u7684\u4f7f\u7528\u65b9\u5f0f\uff08\u5982\u901a\u8fc7\u6bd4\u8f83\u8f6c\u79fb\u4e0e\u975e\u8f6c\u79fb\u7684\u80bf\u7624\u6837\u672c\u5f97\u5230\u4e0e\u8f6c\u79fb\u76f8\u5173\u7684\u5206\u5b50\u7279\u5f81\uff0c\u57fa\u4e8e\u8fd9\u4e2a\u5206\u5b50\u7279\u5f81\u8fdb\u884ccmap\u5206\u6790\u5c31\u6709\u53ef\u80fd\u627e\u5230\u6f5c\u5728\u5bf9\u6297\u8f6c\u79fb\u7684\u836f\u7269\u3002<\/span> <\/span><o:page><\/o:page><\/p>\n<img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-ratio=\"0.5302713987473904\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-11-26_\u300c\u4ed8\u8d39\u300d\u3010\u4ee3\u7801\u5206\u4eab-15\u30118+\u80bf\u7624\u751f\u4fe1\u6587\u7ae0\u7684\u5ba0\u513f-CMAP\u80bf\u7624\u836f\u7269\u9884\u6d4b\u5206\u6790\/4_Qt8ib11Jr3DhEGWdPs1ia5vYpqceJA.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAy9o4ZfUgVysEzia9ic710OTficwg3D5I36xbuZzDvgB1Egx6jfAQt8ib11Jr3DhEGWdPs1ia5vYpqceJA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"958\" height=\"293.6000061035156\" width=\"553.739990234375\" \/><\/span><\/p>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;letter-spacing: 0.578px;white-space: normal;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);text-align: left;\">\n<section style=\"outline: 0px;font-size: 16px;text-indent: 0em;\">\n<section powered-by=\"xiumi.us\" style=\"margin: 10px;outline: 0px;justify-content: flex-start;display: flex;flex-flow: row;\">\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;display: inline-block;width: 558px;vertical-align: top;border-style: dashed;border-width: 1px;border-color: rgb(62, 62, 62);align-self: flex-start;flex: 0 0 auto;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;\">\n<section style=\"outline: 0px;display: inline-block;width: 536px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(144, 215, 236);border-right-color: rgb(46, 172, 109);box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-bottom-left-radius: 0px;\">\n<section powered-by=\"xiumi.us\" style=\"padding-right: 3px;padding-left: 3px;outline: 0px;\">\n<section style=\"margin-top: 0.95em;margin-bottom: -0.65em;outline: 0px;display: inline-block;width: 520px;vertical-align: top;\">\n<section style=\"margin-top: -1em;padding: 3px 10px;outline: 0px;display: inline-block;vertical-align: top;color: rgb(0, 154, 68);\">\n\u5f80\u671f\u63a8\u8350<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;text-align: justify;\">\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491794&idx=1&sn=2b7a4de95169c79202e44813885a8250&chksm=cf7f7017f808f9015689839fe4057fd418bf7b20eb1dfb5a28cd92e56a41b5605e62bfbc16fb&scene=21#wechat_redirect\" textvalue=\"1.\u642d\u5efa\u751f\u4fe1\u5206\u6790\u6d41\u6c34\u7ebf\uff0c\u5982\u5de5\u5382\u4e00\u683724\u5c0f\u65f6\u8fd0\u8f6cSnakemake\u2014\u2014\u8fdb\u9636\u547d\u4ee4\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;font-size: 15px;\" rel=\"noopener\">1.\u642d\u5efa\u751f\u4fe1\u5206\u6790\u6d41\u6c34\u7ebf\uff0c\u5982\u5de5\u5382\u4e00\u683724\u5c0f\u65f6\u8fd0\u8f6cSnakemake\u2014\u2014\u8fdb\u9636\u547d\u4ee4<\/a> <\/section>\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491705&idx=1&sn=9ff9b6da28b3a256a99c6697d589be66&chksm=cf7f70bcf808f9aafd1019a0bba3dd3a55e2867dbb9a09203f13c2683adf867094637c405ed1&scene=21#wechat_redirect\" textvalue=\"2.\u6bd4blast\u8fd8\u4f18\u79c0\u7684\u5e8f\u5217\u6bd4\u5bf9\u5de5\u5177\uff1fHMMER\u6765\u4e86\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;font-size: 15px;\" rel=\"noopener\">2.\u6bd4blast\u8fd8\u4f18\u79c0\u7684\u5e8f\u5217\u6bd4\u5bf9\u5de5\u5177\uff1fHMMER\u6765\u4e86<\/a><\/section>\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491909&idx=1&sn=902e34bcf53e605fba2b457ec6a33e36&chksm=cf7f7180f808f8961542f458a49da14e85d8831449fb65fbf2623d55affc564686a5422f56fd&scene=21#wechat_redirect\" textvalue=\"3.\u5bf9\u5355\u7ec6\u80de\u5206\u6790\u6beb\u65e0\u5934\u7eea\uff1f\u8ba9popsicleR\u9886\u4f60\u5165\u95e8\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;font-size: 15px;\" rel=\"noopener\">3.\u5bf9\u5355\u7ec6\u80de\u5206\u6790\u6beb\u65e0\u5934\u7eea\uff1f\u8ba9popsicleR\u9886\u4f60\u5165\u95e8<\/a><\/section>\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491905&idx=1&sn=fb34ebd6282962c7803badaee7a39096&chksm=cf7f7184f808f8929608c0050344ad86193d0fc6455c1c18e16cc17bf4b37832b63d3b18284e&scene=21#wechat_redirect\" textvalue=\"4.\u5c0f\u679c\u5e26\u4f60\u7ed8\u5236ROC\u66f2\u7ebf\u8bc4\u4f30\u751f\u5b58\u9884\u6d4b\u80fd\u529b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);cursor: pointer;outline: 0px;font-size: 15px;\" rel=\"noopener\">4.\u5c0f\u679c\u5e26\u4f60\u7ed8\u5236ROC\u66f2\u7ebf\u8bc4\u4f30\u751f\u5b58\u9884\u6d4b\u80fd\u529b<\/a><\/section>\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247493633&idx=1&sn=2263dfe7572c0bcf6816c2c1a37d79de&chksm=cf7f78c4f808f1d2209321d6ace39fde5fa60c0691b56f88eac21916f5a2872ce8ee345f1d5f&scene=21#wechat_redirect\" textvalue=\"\u8f6f\u4ef6\u5305\u5b89\u88c5\u3001\u6253\u602a\u5feb\u53c8\u597d\uff0c1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff1b\u8fd8\u6709\u6bd4\u8fd9\u66f4\u7701\u94b1\u7684\u561b\uff01\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;letter-spacing: 0.578px;font-size: 15px;\" rel=\"noopener\">5.\u8f6f\u4ef6\u5305\u5b89\u88c5\u3001\u6253\u602a\u5feb\u53c8\u597d\uff0c1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff1b\u8fd8\u6709\u6bd4\u8fd9\u66f4\u7701\u94b1\u7684\u561b\uff01\uff01\uff01<\/a><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;letter-spacing: 0.578px;text-indent: 0em;white-space: normal;text-align: left;line-height: normal;font-size: 12pt;font-family: helvetica;color: rgb(0, 0, 0);break-after: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.38981481481481484\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_FbEg9fibwQicL8l2ExKOZZTmAHXabQ-4.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAx3HetBkB7aOGibFWKqibqIATyC4zFibzCgdrxFwRep6cDMLIbA0FbEg9fibwQicL8l2ExKOZZTmAHXabQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"font-size: var(--articleFontsize);letter-spacing: 0.034em;caret-color: rgba(0, 0, 0, 0);\" \/><\/section>\n<section style=\"margin-bottom: 0px;letter-spacing: 0.578px;text-indent: 0em;white-space: normal;font-size: 16px;\">\u5982\u679c\u9700\u8981\u5b8c\u6574\u7684\u4ee3\u7801\u53ef\u4ee5\u70b9\u51fb\u4ed8\u8d39\u83b7\u53d6\u54e6!\u4eca\u5929\u5c0f\u679c\u7684\u5206\u4eab\u5c31\u5230\u8fd9\u91cc\uff0c\u5982\u679c\u5c0f\u4f19\u4f34\u6709\u5176\u4ed6\u6570\u636e\u5206\u6790\u9700\u6c42\uff0c\u53ef\u4ee5\u5c1d\u8bd5\u672c\u516c\u53f8\u65b0\u5f00\u53d1\u7684\u751f\u4fe1\u5206\u6790\u5c0f\u5de5\u5177\u4e91\u5e73\u53f0\uff0c\u5b63\u4ee3\u7801\u5b8c\u6210\u5206\u6790\uff0c\u975e\u5e38\u65b9\u4fbf\u5965!<\/span><\/section>\n<mp-pay-preview-filter data-offset=\"23\"><\/mp-pay-preview-filter><\/p>\n<\/content>\n<\/div>\n<\/body> \n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"\u300c\u4ed8\u8d39\u300d\u3010\u4ee3\u7801\u5206\u4eab-15\u30118+\u80bf\u7624\u751f\u4fe1\u6587\u7ae0\u7684\u5ba0\u513f-CMAP\u80bf\u7624\u836f\u7269\u9884\u6d4b\u5206\u6790 \u539f\u521b \u5c0f\u679c& […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/54577"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=54577"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/54577\/revisions"}],"predecessor-version":[{"id":54585,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/54577\/revisions\/54585"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=54577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=54577"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=54577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}