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normal;\">\u5bf9\u4e8e\u7b2c\u4e00\u6b21\u63a5\u89e6ROC\u66f2\u7ebf\u7684\u5c0f\u4f19\u4f34\u4e5f\u611f\u89c9\u6709\u4e9b\u4e91\u91cc\u96fe\u91cc\uff0c\u8fd9\u4e0d\u4f60\u7684\u5e2e\u624b\u5c0f\u56fe\u6765\u4e86<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"display: flex;flex-flow: row nowrap;text-align: center;justify-content: center;margin-top: 10px;margin-bottom: 20px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrhKiaBS3qhRTewUL8phEUfibPAeMVGg0qZFLkmsnBdXJswONbOiaBFQ3fA\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 auto;align-self: stretch;min-width: 10%;height: auto;background-color: rgb(254, 227, 229);box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(84, 54, 54);padding-right: 10px;padding-left: 10px;text-align: justify;font-size: 17px;letter-spacing: 3px;\">\n<p style=\"white-space: normal;\"><strong>\u5e94\u7528\u573a\u666f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrqa5RzcJreBp82LR7HHu2AibzaVw8DBuRXBIg4Vd2RYh30QictCVtzujA\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"text-indent: 0em;white-space: normal;\">\u5728\u9009\u62e9\u8bca\u65ad\u8bd5\u9a8c\u65f6\uff0c\u8bb8\u591a\u7814\u7a76\u8005\u4f1a\u5728\u7075\u654f\u5ea6\u548c\u7279\u5f02\u5ea6\u4e4b\u95f4\u8fdb\u884c\u8270\u96be\u7684\u53d6\u820d\u3002\u90a3\u4e48\uff0c\u662f\u5426\u53ef\u4ee5\u7efc\u5408\u8003\u8651\u7075\u654f\u5ea6\u548c\u7279\u5f02\u5ea6\u7684\u7279\u70b9\uff0c\u6839\u636e\u4e00\u4e2a\u6307\u6807\u8bc4\u4ef7\u8bca\u65ad\u8bd5\u9a8c\u7684\u51c6\u786e\u6027\u5462\uff1fLusted\u4e8e1971\u5e74\u63d0\u51fa\u53d7\u8bd5\u8005\u5de5\u4f5c\u7279\u5f81\u66f2\u7ebf\uff08receiver operating characteristic curve\uff0c\u7b80\u79f0ROC\u66f2\u7ebf\uff09\uff0c\u7528\u6765\u63cf\u8ff0\u8bca\u65ad\u8bd5\u9a8c\u7684\u5185\u5728\u771f\u5b9e\u7a0b\u5ea6\uff0c\u5e94\u7528\u5341\u5206\u5e7f\u6cdb\u3002<\/p>\n<p style=\"text-indent: 2em;white-space: normal;\"><br \/><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\">ROC\uff08Receiver Operating Characteristic\uff09\u66f2\u7ebf\u5373\u53d7\u8bd5\u8005\u5de5\u4f5c\u7279\u5f81\u66f2\u7ebf\u3002ROC\u66f2\u7ebf\u4e0e\u5750\u6807\u8f74\u56f4\u6210\u7684\u9762\u79ef\u88ab\u79f0\u4e3aAUC\uff08Area Under Curve\uff09\uff0c\u8fd9\u4e24\u4e2a\u6307\u6807\u548c\u654f\u611f\u6027\u3001\u7279\u5f02\u6027\u548c\u51c6\u786e\u6027\u4e00\u8d77\uff0c\u662f\u8bc4\u4f30\u7b97\u6cd5\u6a21\u578b\u6027\u80fd\u5e38\u7528\u7684\u6307\u6807\u3002<\/p>\n<p style=\"text-indent: 2em;white-space: normal;\"><br \/><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\"><strong>\u5728\u8fdb\u4e00\u6b65\u4ecb\u7ecdROC\u66f2\u7ebf\u5982\u4f55\u7ed8\u5236\u4e4b\u524d\uff0c\u5148\u548c\u5c0f\u4f19\u4f34\u4e00\u8d77\u7406\u89e3\u8fd9\u51e0\u4e2a\u6982\u5ff5\u3002<\/strong><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\"><br \/><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\">TP\uff08True Positives\uff09\uff0cTN\uff08True Negatives\uff09\uff0cFP\uff08False Positives\uff09\uff0cFN\uff08False Negatives\uff09\u5206\u522b\u4e3a\u9633\u6027\u6837\u672c\u6b63\u786e\u5206\u7c7b\u6570\u91cf\u3001\u9634\u6027\u6837\u672c\u6b63\u786e\u5206\u7c7b\u6570\u91cf\u3001\u9633\u6027\u6837\u672c\u9519\u8bef\u5206\u7c7b\u6570\u91cf\u4ee5\u53ca\u9634\u6027\u6837\u672c\u9519\u8bef\u5206\u7c7b\u6570\u91cf\u3002<\/p>\n<p style=\"text-indent: 0em;white-space: normal;\"><br \/><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\">\u9633\u6027\u6837\u672c\u6b63\u786e\u5206\u7c7b\u6570\u91cf\u5360\u9633\u6027\u6837\u672c\u603b\u6570\u7684\u6bd4\u4f8bTPR\uff08\u5373\u654f\u611f\u6027\uff0cSensitivity\uff09\uff0c\u9634\u6027\u6837\u672c\u6b63\u786e\u5206\u7c7b\u7684\u6570\u91cf\u5360\u9634\u6027\u6837\u672c\u603b\u6570\u7684\u6bd4\u4f8bFPR\uff08\u53731-\u7279\u5f02\u6027\uff0c1-Specificity\uff09<\/p>\n<p style=\"text-indent: 2em;white-space: normal;\"><br \/><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\">ROC\u66f2\u7ebf\u662f\u4ee5\u771f\u9633\u6027\u7387\uff08\u7075\u654f\u5ea6\uff09\u4e3a\u7eb5\u5750\u6807\uff0c\u5047\u9633\u6027\u7387\uff081-\u7279\u5f02\u5ea6\uff09\u4e3a\u6a2a\u5750\u6807\u7ed8\u5236\u7684\u3002\u6bcf\u4e00\u4e2a\u70b9\u90fd\u5bf9\u5e94\u8bca\u65ad\u8bd5\u9a8c\u7684\u4e00\u4e2a\u622a\u70b9\uff0c\u6211\u4eec\u5c06\u8fd9\u4e9b\u53ef\u80fd\u7684\u70b9\u8fde\u63a5\u8d77\u6765\u5373\u53ef\u5236\u4f5c\u51fa\u7ecf\u9a8cROC\u66f2\u7ebf\uff08empirical ROC curve\uff09\u3002\u8be5\u65b9\u6cd5\u53ef\u4ee5\u5e2e\u52a9\u7814\u7a76\u8005\u7b80\u5355\u3001\u76f4\u89c2\u5730\u5206\u6790\u8bca\u65ad\u8bd5\u9a8c\u7684\u4e34\u5e8a\u51c6\u786e\u6027\uff0c\u9009\u62e9\u66f4\u52a0\u5408\u9002\u7684\u622a\u70b9\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\">ROC\u66f2\u7ebf\u662f\u5e38\u89c1\u7684\u7edf\u8ba1\u5206\u6790\u65b9\u6cd5\u4e4b\u4e00\uff0c\u76ee\u524d\u5e7f\u6cdb\u5e94\u7528\u4e8e\u533b\u5b66\u8bca\u65ad\u3001\u751f\u7269\u4fe1\u606f\u5b66\u3001\u6570\u636e\u6316\u6398\u548c\u673a\u5668\u5b66\u4e60\u7b49\u7814\u7a76\u4e2d\uff0c\u7528\u6765\u8bc4\u5224\u5206\u7c7b\u3001\u68c0\u6d4b\u7ed3\u679c\u7684\u597d\u574f\u3002ROC\u66f2\u7ebf\u53ef\u7528\u4e8e\u8bc4\u4ef7\u751f\u7269\u6807\u8bb0\u7269(biomarker)\u7684\u8868\u73b0\u4ee5\u53ca\u6bd4\u8f83\u4e0d\u540c\u6253\u5206\u65b9\u6cd5(scoring methods)\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<section style=\"display: flex;flex-flow: row nowrap;text-align: center;justify-content: center;margin-top: 10px;margin-bottom: 20px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrhKiaBS3qhRTewUL8phEUfibPAeMVGg0qZFLkmsnBdXJswONbOiaBFQ3fA\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 auto;align-self: stretch;min-width: 10%;height: auto;background-color: rgb(254, 227, 229);box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(84, 54, 54);padding-right: 10px;padding-left: 10px;text-align: justify;font-size: 17px;letter-spacing: 3px;\">\n<p style=\"white-space: normal;\"><strong>\u90a3\u4e48\uff0cROC\u66f2\u7ebf\u5e94\u8be5\u5982\u4f55\u7ed8\u5236\u5462\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrqa5RzcJreBp82LR7HHu2AibzaVw8DBuRXBIg4Vd2RYh30QictCVtzujA\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u52a0\u8f7dpROC\u5305<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">library(pROC) #\u9700\u8981\u63d0\u524d\u5b89\u88c5<\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u6570\u636e\u51c6\u5907<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.2564814814814815\" data-s=\"300,640\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_Bpia0x2BpZnZJ7uvibRd94tjsdCf2g.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrn4It9YXAY8cibrpZ7AWQGMiaHxslBpia0x2BpZnZJ7uvibRd94tjsdCf2g\/640?wx_fmt=png'\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u5c0f\u56fe\u8fd9\u91cc\u753b\u4e24\u4e2a\u57fa\u56e0\u6f14\u793a<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">predicted <- read.table(<span class=\"code-snippet__string\">\"data\/\u6570\u636e\/GSE1919\u751f\u5b58\u5206\u6790.txt\"<\/span>,sep= <span class=\"code-snippet__string\">\"t\"<\/span> ,header = T)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__meta\"># colnames(predicted) =<span class=\"code-snippet__meta-string\">\"predicted\"<\/span><\/span><\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u63d0\u53d6\u57fa\u56e0<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">rownames(predicted) = predicted$id<\/span><\/code><code><span class=\"code-snippet_outer\">predicted = predicted[c(<span class=\"code-snippet__string\">\"surstat\"<\/span>,<span class=\"code-snippet__string\">\"CD52\"<\/span>,<span class=\"code-snippet__string\">\"TNFRSF17\"<\/span>),]#\u6839\u636e\u81ea\u5df1\u7684\u6570\u636e\u60c5\u51b5\u8fdb\u884c\u57fa\u56e0\u8c03\u6574<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.2874074074074074\" data-s=\"300,640\" data-type=\"png\" data-w=\"675\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_Lt2jK30yZInALKd0vrpnpuTK0Cib1A.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdr3JVatic7a0CvXFlg1ZMeUtiaNZCLt2jK30yZInALKd0vrpnpuTK0Cib1A\/640?wx_fmt=png'\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u5206\u7ec4\u4fe1\u606f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">actual = predicted[c(<span class=\"code-snippet__string\">\"surstat\"<\/span>),]<\/span><\/code><code><span class=\"code-snippet_outer\">actual = t(actual)<\/span><\/code><code><span class=\"code-snippet_outer\">actual = actual[<span class=\"code-snippet__number\">-1<\/span>,]<\/span><\/code><code><span class=\"code-snippet_outer\">actual = gsub(<span class=\"code-snippet__string\">\"control\"<\/span> , <span class=\"code-snippet__string\">\"0\"<\/span>, actual)<\/span><\/code><code><span class=\"code-snippet_outer\">actual = gsub(<span class=\"code-snippet__string\">\"arthritis\"<\/span> , <span class=\"code-snippet__string\">\"1\"<\/span>, actual)<\/span><\/code><code><span class=\"code-snippet_outer\">actual = as.numeric(actual)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.12470023980815348\" data-s=\"300,640\" data-type=\"png\" data-w=\"417\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_1AxDsp7U5HIEA9icXDwskUQ8nW9I6w.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrYsPdjboXtfpWczToibFeicic9DNF1AxDsp7U5HIEA9icXDwskUQ8nW9I6w\/640?wx_fmt=png'\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">predicted = predicted[<span class=\"code-snippet__number\">-1<\/span>,<span class=\"code-snippet__number\">-1<\/span>]<\/span><\/code><code><span class=\"code-snippet_outer\">predicted = t(predicted)<\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u5c06\u6570\u636e\u6846\u4e2d\u6240\u6709\u7684\u5217\u8f6c\u5316\u4e3a\u6570\u5b57\u578b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">a = predicted<\/span><\/code><code><span class=\"code-snippet_outer\">a <- apply(a, <span class=\"code-snippet__number\">2<\/span>, as.numeric)<\/span><\/code><code><span class=\"code-snippet_outer\">rownames(a) = rownames(predicted)<\/span><\/code><code><span class=\"code-snippet_outer\">predicted = a<\/span><\/code><code><span class=\"code-snippet_outer\">predicted = data.frame(predicted)<\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>ROC\u5206\u6790<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">roc = roc(actual, predicted$CD52, percent = TRUE, ci = TRUE) # ROC\u5206\u6790<\/span><\/code><code><span class=\"code-snippet_outer\">roc2 = roc(actual, predicted$TNFRSF17, percent = TRUE, ci = TRUE) # ROC\u5206\u6790<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.2674897119341564\" data-s=\"300,640\" data-type=\"png\" data-w=\"729\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_sSK1q3dicQPYPgqpxQfDOrk9Ks9iag.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrF5icmyxK018GM0NoR0P4k3WtWBPsSK1q3dicQPYPgqpxQfDOrk9Ks9iag\/640?wx_fmt=png'\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">best = coords(roc, <span class=\"code-snippet__string\">\"best\"<\/span>,ret = <span class=\"code-snippet__string\">\"all\"<\/span>,transpose = F) #\u6700\u4f73\u5206\u5272\u70b9<\/span><\/code><code><span class=\"code-snippet_outer\">best2 = coords(roc2, <span class=\"code-snippet__string\">\"best\"<\/span>,ret = <span class=\"code-snippet__string\">\"all\"<\/span>,transpose = F) #\u6700\u4f73\u5206\u5272\u70b9<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">outTab = data.frame(<\/span><\/code><code><span class=\"code-snippet_outer\"> Gene = <span class=\"code-snippet__string\">\"CD52\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"> AUC = round(roc$auc,<span class=\"code-snippet__number\">3<\/span>) ,<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"95% CI\"<\/span> = paste(round(roc$ci[c(<span class=\"code-snippet__number\">1<\/span>,<span class=\"code-snippet__number\">3<\/span>)],<span class=\"code-snippet__number\">3<\/span>), collapse = <span class=\"code-snippet__string\">\"-\"<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"Cutoff value\"<\/span> = round(best$threshold,<span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> Spensitivity = round(best$sensitivity,<span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> Specificity = round(best$specificity,<span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> check.names = FALSE<\/span><\/code><code><span class=\"code-snippet_outer\">)<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">outTab2 = data.frame(<\/span><\/code><code><span class=\"code-snippet_outer\"> Gene = <span class=\"code-snippet__string\">\"TNFRSF17\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"> AUC = round(roc2$auc,<span class=\"code-snippet__number\">3<\/span>) ,<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"95% CI\"<\/span> = paste(round(roc2$ci[c(<span class=\"code-snippet__number\">1<\/span>,<span class=\"code-snippet__number\">3<\/span>)],<span class=\"code-snippet__number\">3<\/span>), collapse = <span class=\"code-snippet__string\">\"-\"<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"Cutoff value\"<\/span> = round(best2$threshold,<span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> Spensitivity = round(best2$sensitivity,<span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> Specificity = round(best2$specificity,<span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> check.names = FALSE<\/span><\/code><code><span class=\"code-snippet_outer\">)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__meta\"># write.csv(outTab , <span class=\"code-snippet__meta-string\">\"D:\/ ROC\/output\/ROCplot.csv\"<\/span>)<\/span><\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u7ed8\u5236\u56fe\u7247<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">rocobj1 <- plot.roc(actual, predicted$CD52,percent=TRUE, col=<span class=\"code-snippet__string\">\"#69C5CE\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">rocobj2 <- lines.roc(actual, predicted$TNFRSF17, percent=TRUE, col=<span class=\"code-snippet__string\">\"#B974AD\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">legend(<span class=\"code-snippet__string\">\"bottomright\"<\/span>, legend=c(paste0(<span class=\"code-snippet__string\">\"CD52\"<\/span>,<span class=\"code-snippet__string\">\"-AUC\"<\/span>, outTab$AUC , <span class=\"code-snippet__string\">\"(\"<\/span> , outTab$`<span class=\"code-snippet__number\">95<\/span>% CI` , <span class=\"code-snippet__string\">\")\"<\/span>), <\/span><\/code><code><span class=\"code-snippet_outer\"> paste0(<span class=\"code-snippet__string\">\"TNFRSF17\"<\/span>,<span class=\"code-snippet__string\">\"-AUC\"<\/span>, outTab2$AUC , <span class=\"code-snippet__string\">\"(\"<\/span> , outTab2$`<span class=\"code-snippet__number\">95<\/span>% CI` , <span class=\"code-snippet__string\">\")\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"> ), <\/span><\/code><code><span class=\"code-snippet_outer\"> col=c(<span class=\"code-snippet__string\">\"#69C5CE\"<\/span>, <\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"#B974AD\"<\/span>), lwd=<span class=\"code-snippet__number\">2<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9740740740740741\" data-s=\"300,640\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_T5dwhCLbeejicTygmTo07w4REeVbtQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrVhJjcKVndN2XWBZSUErapDq7TT5dwhCLbeejicTygmTo07w4REeVbtQ\/640?wx_fmt=png'\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u8fd9\u6837\u56fe\u7247\u5c31\u753b\u5b8c\u4e86\uff0c\u662f\u4e0d\u662f\u4ee5\u4e3a\u7ed3\u675f\u4e86~<\/p>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u73b0\u5728\u5f00\u59cb\u56fe\u7247\u89e3\u8bfb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 30px 0% 10px;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;background-color: rgb(233, 250, 255);padding-bottom: 10px;padding-left: 10px;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"display: flex;flex-flow: row nowrap;text-align: justify;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;margin-top: -20px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;padding-right: 5px;\">\n<section style=\"margin-right: 0%;margin-left: 0%;text-align: center;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;\">\n<section style=\"display: inline-block;vertical-align: top;border-right: 0.35em solid rgb(98, 169, 187);border-bottom: 0.65em solid rgb(98, 169, 187);max-width: 5% !important;border-top: 0.65em solid transparent !important;border-left: 0.35em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<section style=\"display: inline-block;vertical-align: top;background-color: rgb(139, 207, 224);padding-right: 8px;padding-left: 8px;font-size: 19px;color: rgb(255, 255, 255);letter-spacing: 0px;line-height: 2;max-width: 95% !important;\">\n<p>Q1\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;align-self: flex-start;height: auto;padding-top: 3px;padding-bottom: 3px;padding-left: 10px;background-color: rgb(98, 169, 187);\">\n<section style=\"color: rgb(255, 255, 255);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>ROC\u66f2\u7ebf\u6709\u4ec0\u4e48\u542b\u4e49\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: justify;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;padding-top: 10px;padding-right: 10px;padding-left: 10px;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"color: rgb(106, 106, 106);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\uff081\uff09ROC\u66f2\u7ebf\u8d8a\u9760\u8fd1\u5de6\u4e0a\u89d2,\u5219\u8868\u793a\u5206\u7c7b\u8d8a\u597d\uff0c\u6b63\u786e\u7387\u8d8a\u9ad8\uff1b<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\uff082\uff09ROC\u66f2\u7ebf\u4e0b\u7684\u9762\u79efAUC\uff0c\u4ecb\u4e8e0.1\u548c1\u4e4b\u95f4\uff0c\u4f5c\u4e3a\u6570\u503c\u53ef\u4ee5\u76f4\u89c2\u7684\u8bc4\u4ef7\u5206\u7c7b\u597d\u574f\uff0c\u6570\u503c\u8d8a\u5927\uff0c\u8868\u793a\u8d8a\u597d\uff0c\u6b63\u786e\u7387\u8d8a\u9ad8\uff080.6\u4ee5\u4e0a\u4e3a\u4f73\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 30px 0% 10px;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;background-color: rgb(233, 250, 255);padding-bottom: 10px;padding-left: 10px;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"display: flex;flex-flow: row nowrap;text-align: justify;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;margin-top: -20px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;padding-right: 5px;\">\n<section style=\"margin-right: 0%;margin-left: 0%;text-align: center;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;\">\n<section style=\"display: inline-block;vertical-align: top;border-right: 0.35em solid rgb(98, 169, 187);border-bottom: 0.65em solid rgb(98, 169, 187);max-width: 5% !important;border-top: 0.65em solid transparent !important;border-left: 0.35em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<section style=\"display: inline-block;vertical-align: top;background-color: rgb(139, 207, 224);padding-right: 8px;padding-left: 8px;font-size: 19px;color: rgb(255, 255, 255);letter-spacing: 0px;line-height: 2;max-width: 95% !important;\">\n<p><strong>Q2\uff1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;align-self: flex-start;height: auto;padding-top: 3px;padding-bottom: 3px;padding-left: 10px;background-color: rgb(98, 169, 187);\">\n<section style=\"color: rgb(255, 255, 255);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u5982\u4f55\u4e0d\u4f7f\u7528R\u8bed\u8a00\u7ed8\u5236ROC\u66f2\u7ebf\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: justify;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;padding-top: 10px;padding-right: 10px;padding-left: 10px;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"color: rgb(106, 106, 106);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5c0f\u56fe\u548c\u56e2\u961f\u5c0f\u4f19\u4f34\u4eec\u5f00\u53d1\u4e86\u4e00\u4e2a\u5728\u7ebf\u7684\u5206\u6790\u7f51\u7ad9\u5e73\u53f0\u2014\u2014\u4e91\u751f\u4fe1\u751f\u7269\u4fe1\u606f\u5b66\u5e73\u53f0\uff08http:\/\/www.biocloudservice.com\/home.html\uff0c\u514d\u8d39\u7684\u54e6~\uff09<\/p>\n<p style=\"white-space: normal;\">\u5c0f\u4f19\u4f34\u8d76\u7d27\u52a8\u624b\u753b\u8d77\u6765\u5427~<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u6211\u4eec\u4e0b\u671f\u89c1~<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;border-color: rgb(176, 176, 176);padding: 7px;\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: rgba(249, 238, 237, 0.5);padding: 18px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;font-size: 14px;\">\n<p style=\"white-space: normal;\">\u6b22\u8fce\u4f7f\u7528\uff1a\u4e91\u751f\u4fe1\u5e73\u53f0 ( http:\/\/www.biocloudservice.com\/home.html)<\/p>\n<\/section>\n<\/section>\n<section style=\"transform: scale(0.5);transform-origin: center center;margin-top: -65px;margin-bottom: -65px;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"258\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_miak4XaVYo1Wpv5p1oTNTskKg4AtTA.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrOtBdxKJicYgnkZB1lR63w4yAj1miak4XaVYo1Wpv5p1oTNTskKg4AtTA\/640?wx_fmt=jpeg'\" \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:42.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:42.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;background-color: rgb(249, 174, 165);padding: 10px 0px;\" width=\"96.3700%\">\n<section style=\"line-height: 1;text-align: center;font-size: 17px;color: rgb(255, 255, 255);letter-spacing: 5px;\" powered-by=\"xiumi.us\">\n<p><strong>\u5f80\u671f\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:42.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:42.classicTable1:1.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<p powered-by=\"xiumi.us\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247483859&idx=1&sn=cf52c37efa699b46f673eb84872797ae&chksm=c1b17c2ef6c6f538f2904aaa795ee21cde7cba143f85705fd40e65abc5386067952b797ac76c&scene=21#wechat_redirect\" textvalue=\"\u7eaf\u4ee3\u7801\u5b9e\u64cd\uff0c\u6559\u4f60\u5feb\u901f\u62ff\u634f\u514d\u75ab\u6d78\u6da6\u5206\u6790\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\"><span style=\"letter-spacing: 0.034em;\">\u7eaf\u4ee3\u7801\u5b9e\u64cd\uff0c\u6559\u4f60\u5feb\u901f\u62ff\u634f<\/span><span style=\"letter-spacing: 0.034em;\">\u514d\u75ab\u6d78\u6da6\u5206\u6790\uff01<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:42.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:42.classicTable1:2.td@@0\" 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right;letter-spacing: 4px;\" powered-by=\"xiumi.us\">\n<p><strong>\u70b9\u51fb\u84dd\u5b57<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;border-left: 4px solid rgb(242, 183, 183);border-bottom-left-radius: 0px;flex: 100 100 0%;align-self: stretch;height: auto;padding: 3px 10px;background-color: rgba(254, 245, 240, 0.8);\">\n<section style=\"color: rgb(181, 126, 121);font-size: 17px;letter-spacing: 4px;\" powered-by=\"xiumi.us\">\n<p><strong>\u5173\u6ce8\u5c0f\u56fe<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u4eca\u5929\u5c0f\u56fe\u7ed8\u5236\u4e86ROC\u66f2\u7ebf\uff0c\u8feb\u4e0d\u53ca\u5f85\u7684\u60f3\u5206\u4eab\u7ed9\u5c0f\u4f19\u4f34\u4eec~<\/p>\n<p style=\"white-space: normal;\">\u76f8\u4fe1\u6709\u5f88\u591a\u5c0f\u4f19\u4f34\u5728\u6700\u8fd1\u7684\u5206\u6790\u4e2d\u4e5f\u6709\u7528\u5230\u5427<\/p>\n<p style=\"white-space: 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top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 auto;align-self: stretch;min-width: 10%;height: auto;background-color: rgb(254, 227, 229);box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(84, 54, 54);padding-right: 10px;padding-left: 10px;text-align: justify;font-size: 17px;letter-spacing: 3px;\">\n<p style=\"white-space: normal;\"><strong>\u5e94\u7528\u573a\u666f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrqa5RzcJreBp82LR7HHu2AibzaVw8DBuRXBIg4Vd2RYh30QictCVtzujA\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"text-indent: 0em;white-space: normal;\">\u5728\u9009\u62e9\u8bca\u65ad\u8bd5\u9a8c\u65f6\uff0c\u8bb8\u591a\u7814\u7a76\u8005\u4f1a\u5728\u7075\u654f\u5ea6\u548c\u7279\u5f02\u5ea6\u4e4b\u95f4\u8fdb\u884c\u8270\u96be\u7684\u53d6\u820d\u3002\u90a3\u4e48\uff0c\u662f\u5426\u53ef\u4ee5\u7efc\u5408\u8003\u8651\u7075\u654f\u5ea6\u548c\u7279\u5f02\u5ea6\u7684\u7279\u70b9\uff0c\u6839\u636e\u4e00\u4e2a\u6307\u6807\u8bc4\u4ef7\u8bca\u65ad\u8bd5\u9a8c\u7684\u51c6\u786e\u6027\u5462\uff1fLusted\u4e8e1971\u5e74\u63d0\u51fa\u53d7\u8bd5\u8005\u5de5\u4f5c\u7279\u5f81\u66f2\u7ebf\uff08receiver operating characteristic curve\uff0c\u7b80\u79f0ROC\u66f2\u7ebf\uff09\uff0c\u7528\u6765\u63cf\u8ff0\u8bca\u65ad\u8bd5\u9a8c\u7684\u5185\u5728\u771f\u5b9e\u7a0b\u5ea6\uff0c\u5e94\u7528\u5341\u5206\u5e7f\u6cdb\u3002<\/p>\n<p style=\"text-indent: 2em;white-space: normal;\"><br \/><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\">ROC\uff08Receiver Operating Characteristic\uff09\u66f2\u7ebf\u5373\u53d7\u8bd5\u8005\u5de5\u4f5c\u7279\u5f81\u66f2\u7ebf\u3002ROC\u66f2\u7ebf\u4e0e\u5750\u6807\u8f74\u56f4\u6210\u7684\u9762\u79ef\u88ab\u79f0\u4e3aAUC\uff08Area Under Curve\uff09\uff0c\u8fd9\u4e24\u4e2a\u6307\u6807\u548c\u654f\u611f\u6027\u3001\u7279\u5f02\u6027\u548c\u51c6\u786e\u6027\u4e00\u8d77\uff0c\u662f\u8bc4\u4f30\u7b97\u6cd5\u6a21\u578b\u6027\u80fd\u5e38\u7528\u7684\u6307\u6807\u3002<\/p>\n<p style=\"text-indent: 2em;white-space: normal;\"><br \/><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\"><strong>\u5728\u8fdb\u4e00\u6b65\u4ecb\u7ecdROC\u66f2\u7ebf\u5982\u4f55\u7ed8\u5236\u4e4b\u524d\uff0c\u5148\u548c\u5c0f\u4f19\u4f34\u4e00\u8d77\u7406\u89e3\u8fd9\u51e0\u4e2a\u6982\u5ff5\u3002<\/strong><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\"><br \/><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\">TP\uff08True Positives\uff09\uff0cTN\uff08True Negatives\uff09\uff0cFP\uff08False Positives\uff09\uff0cFN\uff08False Negatives\uff09\u5206\u522b\u4e3a\u9633\u6027\u6837\u672c\u6b63\u786e\u5206\u7c7b\u6570\u91cf\u3001\u9634\u6027\u6837\u672c\u6b63\u786e\u5206\u7c7b\u6570\u91cf\u3001\u9633\u6027\u6837\u672c\u9519\u8bef\u5206\u7c7b\u6570\u91cf\u4ee5\u53ca\u9634\u6027\u6837\u672c\u9519\u8bef\u5206\u7c7b\u6570\u91cf\u3002<\/p>\n<p style=\"text-indent: 0em;white-space: normal;\"><br \/><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\">\u9633\u6027\u6837\u672c\u6b63\u786e\u5206\u7c7b\u6570\u91cf\u5360\u9633\u6027\u6837\u672c\u603b\u6570\u7684\u6bd4\u4f8bTPR\uff08\u5373\u654f\u611f\u6027\uff0cSensitivity\uff09\uff0c\u9634\u6027\u6837\u672c\u6b63\u786e\u5206\u7c7b\u7684\u6570\u91cf\u5360\u9634\u6027\u6837\u672c\u603b\u6570\u7684\u6bd4\u4f8bFPR\uff08\u53731-\u7279\u5f02\u6027\uff0c1-Specificity\uff09<\/p>\n<p style=\"text-indent: 2em;white-space: normal;\"><br \/><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\">ROC\u66f2\u7ebf\u662f\u4ee5\u771f\u9633\u6027\u7387\uff08\u7075\u654f\u5ea6\uff09\u4e3a\u7eb5\u5750\u6807\uff0c\u5047\u9633\u6027\u7387\uff081-\u7279\u5f02\u5ea6\uff09\u4e3a\u6a2a\u5750\u6807\u7ed8\u5236\u7684\u3002\u6bcf\u4e00\u4e2a\u70b9\u90fd\u5bf9\u5e94\u8bca\u65ad\u8bd5\u9a8c\u7684\u4e00\u4e2a\u622a\u70b9\uff0c\u6211\u4eec\u5c06\u8fd9\u4e9b\u53ef\u80fd\u7684\u70b9\u8fde\u63a5\u8d77\u6765\u5373\u53ef\u5236\u4f5c\u51fa\u7ecf\u9a8cROC\u66f2\u7ebf\uff08empirical ROC curve\uff09\u3002\u8be5\u65b9\u6cd5\u53ef\u4ee5\u5e2e\u52a9\u7814\u7a76\u8005\u7b80\u5355\u3001\u76f4\u89c2\u5730\u5206\u6790\u8bca\u65ad\u8bd5\u9a8c\u7684\u4e34\u5e8a\u51c6\u786e\u6027\uff0c\u9009\u62e9\u66f4\u52a0\u5408\u9002\u7684\u622a\u70b9\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"text-indent: 0em;white-space: normal;\">ROC\u66f2\u7ebf\u662f\u5e38\u89c1\u7684\u7edf\u8ba1\u5206\u6790\u65b9\u6cd5\u4e4b\u4e00\uff0c\u76ee\u524d\u5e7f\u6cdb\u5e94\u7528\u4e8e\u533b\u5b66\u8bca\u65ad\u3001\u751f\u7269\u4fe1\u606f\u5b66\u3001\u6570\u636e\u6316\u6398\u548c\u673a\u5668\u5b66\u4e60\u7b49\u7814\u7a76\u4e2d\uff0c\u7528\u6765\u8bc4\u5224\u5206\u7c7b\u3001\u68c0\u6d4b\u7ed3\u679c\u7684\u597d\u574f\u3002ROC\u66f2\u7ebf\u53ef\u7528\u4e8e\u8bc4\u4ef7\u751f\u7269\u6807\u8bb0\u7269(biomarker)\u7684\u8868\u73b0\u4ee5\u53ca\u6bd4\u8f83\u4e0d\u540c\u6253\u5206\u65b9\u6cd5(scoring methods)\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<section style=\"display: flex;flex-flow: row nowrap;text-align: center;justify-content: center;margin-top: 10px;margin-bottom: 20px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrhKiaBS3qhRTewUL8phEUfibPAeMVGg0qZFLkmsnBdXJswONbOiaBFQ3fA\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 auto;align-self: stretch;min-width: 10%;height: auto;background-color: rgb(254, 227, 229);box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(84, 54, 54);padding-right: 10px;padding-left: 10px;text-align: justify;font-size: 17px;letter-spacing: 3px;\">\n<p style=\"white-space: normal;\"><strong>\u90a3\u4e48\uff0cROC\u66f2\u7ebf\u5e94\u8be5\u5982\u4f55\u7ed8\u5236\u5462\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;align-self: stretch;height: auto;background-position: 0% 0%;background-repeat: repeat-y;background-size: 100%;background-attachment: scroll;background-image: url("https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrqa5RzcJreBp82LR7HHu2AibzaVw8DBuRXBIg4Vd2RYh30QictCVtzujA\/640?wx_fmt=png");\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 5px;height: 10px;vertical-align: top;overflow: hidden;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u52a0\u8f7dpROC\u5305<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">library(pROC) #\u9700\u8981\u63d0\u524d\u5b89\u88c5<\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u6570\u636e\u51c6\u5907<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.2564814814814815\" data-s=\"300,640\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_Bpia0x2BpZnZJ7uvibRd94tjsdCf2g.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrn4It9YXAY8cibrpZ7AWQGMiaHxslBpia0x2BpZnZJ7uvibRd94tjsdCf2g\/640?wx_fmt=png'\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u5c0f\u56fe\u8fd9\u91cc\u753b\u4e24\u4e2a\u57fa\u56e0\u6f14\u793a<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">predicted <- read.table(<span class=\"code-snippet__string\">\"data\/\u6570\u636e\/GSE1919\u751f\u5b58\u5206\u6790.txt\"<\/span>,sep= <span class=\"code-snippet__string\">\"t\"<\/span> ,header = T)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__meta\"># colnames(predicted) =<span class=\"code-snippet__meta-string\">\"predicted\"<\/span><\/span><\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u63d0\u53d6\u57fa\u56e0<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">rownames(predicted) = predicted$id<\/span><\/code><code><span class=\"code-snippet_outer\">predicted = predicted[c(<span class=\"code-snippet__string\">\"surstat\"<\/span>,<span class=\"code-snippet__string\">\"CD52\"<\/span>,<span class=\"code-snippet__string\">\"TNFRSF17\"<\/span>),]#\u6839\u636e\u81ea\u5df1\u7684\u6570\u636e\u60c5\u51b5\u8fdb\u884c\u57fa\u56e0\u8c03\u6574<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.2874074074074074\" data-s=\"300,640\" data-type=\"png\" data-w=\"675\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_Lt2jK30yZInALKd0vrpnpuTK0Cib1A.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdr3JVatic7a0CvXFlg1ZMeUtiaNZCLt2jK30yZInALKd0vrpnpuTK0Cib1A\/640?wx_fmt=png'\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u5206\u7ec4\u4fe1\u606f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">actual = predicted[c(<span class=\"code-snippet__string\">\"surstat\"<\/span>),]<\/span><\/code><code><span class=\"code-snippet_outer\">actual = t(actual)<\/span><\/code><code><span class=\"code-snippet_outer\">actual = actual[<span class=\"code-snippet__number\">-1<\/span>,]<\/span><\/code><code><span class=\"code-snippet_outer\">actual = gsub(<span class=\"code-snippet__string\">\"control\"<\/span> , <span class=\"code-snippet__string\">\"0\"<\/span>, actual)<\/span><\/code><code><span class=\"code-snippet_outer\">actual = gsub(<span class=\"code-snippet__string\">\"arthritis\"<\/span> , <span class=\"code-snippet__string\">\"1\"<\/span>, actual)<\/span><\/code><code><span class=\"code-snippet_outer\">actual = as.numeric(actual)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.12470023980815348\" data-s=\"300,640\" data-type=\"png\" data-w=\"417\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_1AxDsp7U5HIEA9icXDwskUQ8nW9I6w.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrYsPdjboXtfpWczToibFeicic9DNF1AxDsp7U5HIEA9icXDwskUQ8nW9I6w\/640?wx_fmt=png'\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">predicted = predicted[<span class=\"code-snippet__number\">-1<\/span>,<span class=\"code-snippet__number\">-1<\/span>]<\/span><\/code><code><span class=\"code-snippet_outer\">predicted = t(predicted)<\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u5c06\u6570\u636e\u6846\u4e2d\u6240\u6709\u7684\u5217\u8f6c\u5316\u4e3a\u6570\u5b57\u578b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">a = predicted<\/span><\/code><code><span class=\"code-snippet_outer\">a <- apply(a, <span class=\"code-snippet__number\">2<\/span>, as.numeric)<\/span><\/code><code><span class=\"code-snippet_outer\">rownames(a) = rownames(predicted)<\/span><\/code><code><span class=\"code-snippet_outer\">predicted = a<\/span><\/code><code><span class=\"code-snippet_outer\">predicted = data.frame(predicted)<\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>ROC\u5206\u6790<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">roc = roc(actual, predicted$CD52, percent = TRUE, ci = TRUE) # ROC\u5206\u6790<\/span><\/code><code><span class=\"code-snippet_outer\">roc2 = roc(actual, predicted$TNFRSF17, percent = TRUE, ci = TRUE) # ROC\u5206\u6790<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.2674897119341564\" data-s=\"300,640\" data-type=\"png\" data-w=\"729\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_sSK1q3dicQPYPgqpxQfDOrk9Ks9iag.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrF5icmyxK018GM0NoR0P4k3WtWBPsSK1q3dicQPYPgqpxQfDOrk9Ks9iag\/640?wx_fmt=png'\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">best = coords(roc, <span class=\"code-snippet__string\">\"best\"<\/span>,ret = <span class=\"code-snippet__string\">\"all\"<\/span>,transpose = F) #\u6700\u4f73\u5206\u5272\u70b9<\/span><\/code><code><span class=\"code-snippet_outer\">best2 = coords(roc2, <span class=\"code-snippet__string\">\"best\"<\/span>,ret = <span class=\"code-snippet__string\">\"all\"<\/span>,transpose = F) #\u6700\u4f73\u5206\u5272\u70b9<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">outTab = data.frame(<\/span><\/code><code><span class=\"code-snippet_outer\"> Gene = <span class=\"code-snippet__string\">\"CD52\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"> AUC = round(roc$auc,<span class=\"code-snippet__number\">3<\/span>) ,<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"95% CI\"<\/span> = paste(round(roc$ci[c(<span class=\"code-snippet__number\">1<\/span>,<span class=\"code-snippet__number\">3<\/span>)],<span class=\"code-snippet__number\">3<\/span>), collapse = <span class=\"code-snippet__string\">\"-\"<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"Cutoff value\"<\/span> = round(best$threshold,<span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> Spensitivity = round(best$sensitivity,<span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> Specificity = round(best$specificity,<span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> check.names = FALSE<\/span><\/code><code><span class=\"code-snippet_outer\">)<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">outTab2 = data.frame(<\/span><\/code><code><span class=\"code-snippet_outer\"> Gene = <span class=\"code-snippet__string\">\"TNFRSF17\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"> AUC = round(roc2$auc,<span class=\"code-snippet__number\">3<\/span>) ,<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"95% CI\"<\/span> = paste(round(roc2$ci[c(<span class=\"code-snippet__number\">1<\/span>,<span class=\"code-snippet__number\">3<\/span>)],<span class=\"code-snippet__number\">3<\/span>), collapse = <span class=\"code-snippet__string\">\"-\"<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"Cutoff value\"<\/span> = round(best2$threshold,<span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> Spensitivity = round(best2$sensitivity,<span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> Specificity = round(best2$specificity,<span class=\"code-snippet__number\">3<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> check.names = FALSE<\/span><\/code><code><span class=\"code-snippet_outer\">)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__meta\"># write.csv(outTab , <span class=\"code-snippet__meta-string\">\"D:\/ ROC\/output\/ROCplot.csv\"<\/span>)<\/span><\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u7ed8\u5236\u56fe\u7247<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">rocobj1 <- plot.roc(actual, predicted$CD52,percent=TRUE, col=<span class=\"code-snippet__string\">\"#69C5CE\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">rocobj2 <- lines.roc(actual, predicted$TNFRSF17, percent=TRUE, col=<span class=\"code-snippet__string\">\"#B974AD\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">legend(<span class=\"code-snippet__string\">\"bottomright\"<\/span>, legend=c(paste0(<span class=\"code-snippet__string\">\"CD52\"<\/span>,<span class=\"code-snippet__string\">\"-AUC\"<\/span>, outTab$AUC , <span class=\"code-snippet__string\">\"(\"<\/span> , outTab$`<span class=\"code-snippet__number\">95<\/span>% CI` , <span class=\"code-snippet__string\">\")\"<\/span>), <\/span><\/code><code><span class=\"code-snippet_outer\"> paste0(<span class=\"code-snippet__string\">\"TNFRSF17\"<\/span>,<span class=\"code-snippet__string\">\"-AUC\"<\/span>, outTab2$AUC , <span class=\"code-snippet__string\">\"(\"<\/span> , outTab2$`<span class=\"code-snippet__number\">95<\/span>% CI` , <span class=\"code-snippet__string\">\")\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"> ), <\/span><\/code><code><span class=\"code-snippet_outer\"> col=c(<span class=\"code-snippet__string\">\"#69C5CE\"<\/span>, <\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"#B974AD\"<\/span>), lwd=<span class=\"code-snippet__number\">2<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9740740740740741\" data-s=\"300,640\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_T5dwhCLbeejicTygmTo07w4REeVbtQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QvuibS1ohK2CtEl3gcnqcvdrVhJjcKVndN2XWBZSUErapDq7TT5dwhCLbeejicTygmTo07w4REeVbtQ\/640?wx_fmt=png'\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u8fd9\u6837\u56fe\u7247\u5c31\u753b\u5b8c\u4e86\uff0c\u662f\u4e0d\u662f\u4ee5\u4e3a\u7ed3\u675f\u4e86~<\/p>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.3;text-align: justify;letter-spacing: 1px;\">\n<p style=\"white-space: normal;\"><strong>\u73b0\u5728\u5f00\u59cb\u56fe\u7247\u89e3\u8bfb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 30px 0% 10px;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;background-color: rgb(233, 250, 255);padding-bottom: 10px;padding-left: 10px;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"display: flex;flex-flow: row nowrap;text-align: justify;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;margin-top: -20px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;padding-right: 5px;\">\n<section style=\"margin-right: 0%;margin-left: 0%;text-align: center;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;\">\n<section style=\"display: inline-block;vertical-align: top;border-right: 0.35em solid rgb(98, 169, 187);border-bottom: 0.65em solid rgb(98, 169, 187);max-width: 5% !important;border-top: 0.65em solid transparent !important;border-left: 0.35em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<section style=\"display: inline-block;vertical-align: top;background-color: rgb(139, 207, 224);padding-right: 8px;padding-left: 8px;font-size: 19px;color: rgb(255, 255, 255);letter-spacing: 0px;line-height: 2;max-width: 95% !important;\">\n<p>Q1\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;align-self: flex-start;height: auto;padding-top: 3px;padding-bottom: 3px;padding-left: 10px;background-color: rgb(98, 169, 187);\">\n<section style=\"color: rgb(255, 255, 255);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>ROC\u66f2\u7ebf\u6709\u4ec0\u4e48\u542b\u4e49\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: justify;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;padding-top: 10px;padding-right: 10px;padding-left: 10px;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"color: rgb(106, 106, 106);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\uff081\uff09ROC\u66f2\u7ebf\u8d8a\u9760\u8fd1\u5de6\u4e0a\u89d2,\u5219\u8868\u793a\u5206\u7c7b\u8d8a\u597d\uff0c\u6b63\u786e\u7387\u8d8a\u9ad8\uff1b<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\uff082\uff09ROC\u66f2\u7ebf\u4e0b\u7684\u9762\u79efAUC\uff0c\u4ecb\u4e8e0.1\u548c1\u4e4b\u95f4\uff0c\u4f5c\u4e3a\u6570\u503c\u53ef\u4ee5\u76f4\u89c2\u7684\u8bc4\u4ef7\u5206\u7c7b\u597d\u574f\uff0c\u6570\u503c\u8d8a\u5927\uff0c\u8868\u793a\u8d8a\u597d\uff0c\u6b63\u786e\u7387\u8d8a\u9ad8\uff080.6\u4ee5\u4e0a\u4e3a\u4f73\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 30px 0% 10px;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;background-color: rgb(233, 250, 255);padding-bottom: 10px;padding-left: 10px;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"display: flex;flex-flow: row nowrap;text-align: justify;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;margin-top: -20px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;padding-right: 5px;\">\n<section style=\"margin-right: 0%;margin-left: 0%;text-align: center;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;\">\n<section style=\"display: inline-block;vertical-align: top;border-right: 0.35em solid rgb(98, 169, 187);border-bottom: 0.65em solid rgb(98, 169, 187);max-width: 5% !important;border-top: 0.65em solid transparent !important;border-left: 0.35em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<section style=\"display: inline-block;vertical-align: top;background-color: rgb(139, 207, 224);padding-right: 8px;padding-left: 8px;font-size: 19px;color: rgb(255, 255, 255);letter-spacing: 0px;line-height: 2;max-width: 95% !important;\">\n<p><strong>Q2\uff1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 100 100 0%;align-self: flex-start;height: auto;padding-top: 3px;padding-bottom: 3px;padding-left: 10px;background-color: rgb(98, 169, 187);\">\n<section style=\"color: rgb(255, 255, 255);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u5982\u4f55\u4e0d\u4f7f\u7528R\u8bed\u8a00\u7ed8\u5236ROC\u66f2\u7ebf\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: justify;justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;padding-top: 10px;padding-right: 10px;padding-left: 10px;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"color: rgb(106, 106, 106);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: 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