{"id":55165,"date":"2024-06-16T16:17:30","date_gmt":"2024-06-16T08:17:30","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=55165"},"modified":"2024-06-16T16:17:30","modified_gmt":"2024-06-16T08:17:30","slug":"%e6%af%95%e4%b8%9a%e5%b0%b1%e9%9d%a0%e5%ae%83%e4%ba%86%ef%bc%81%e6%9c%ba%e5%99%a8%e5%ad%a6%e4%b9%a0%e5%85%b1%e8%a1%a8%e8%be%be%e7%bd%91%e7%bb%9c%ef%bc%8c%e8%ae%a9mirna%e6%b5%8b%e5%ba%8f%e6%95%b0","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=55165","title":{"rendered":"\u6bd5\u4e1a\u5c31\u9760\u5b83\u4e86\uff01\u673a\u5668\u5b66\u4e60+\u5171\u8868\u8fbe\u7f51\u7edc\uff0c\u8ba9miRNA\u6d4b\u5e8f\u6570\u636e\u5f00\u51fa\u65b0\u7684\u9053\u8def\uff01\u7eaf\u751f\u4fe1\u4e5f\u80fd\u53d19\u5206+\uff01"},"content":{"rendered":"


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8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">3. \u672c\u6587\u8fd8\u4f7f\u7528ROS\/MAP\u6570\u636e\u96c6\u548c\u6765\u81eaGEO\u7684\u72ec\u7acb\u6570\u636e\u96c6\u8fdb\u884c\u4e86\u4e00\u81f4\u7684miRNA\u5171\u8868\u8fbe\u7f51\u7edc\u5206\u6790\u3002\u6b64\u5916\uff0c\u8fd8\u4f7f\u7528\u4e00\u79cd\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u6765\u8bc4\u4f30\u4e2d\u67a2miRNA\u5bf9AD\u5206\u7c7b\u7684\u6027\u80fd\u3002\u60f3\u8981\u5b66\u4e60\u5171\u8868\u8fbe\u7f51\u7edc+\u673a\u5668\u5b66\u4e60\u7684\u5c0f\u4f19\u4f34\u5343\u4e07\u4e0d\u8981\u9519\u8fc7\u4e86~(<\/span><span style=\"font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(255, 0, 0);font-weight: bold;\">ps\uff1a\u8fd9\u7bc7\u6587\u7ae0\u601d\u8def\u6bd4\u8f83\u7b80\u5355\uff0c\u6709\u6ca1\u6709\u7ed9\u4f60\u5e26\u6765\u4e00\u70b9\u542f\u53d1\u5462\uff1f\u611f\u5174\u8da3\u7684\u7ae5\u978b\u53ef\u4ee5\u76f4\u63a5\u6765\u627e\u9986\u957f\uff01\u6b22\u8fce\u76f4\u63a5\u6765\u516c\u4f17\u53f7\u540e\u53f0call\uff01<\/span><span style=\"font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">)\u3002<\/span><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100006476\" data-ratio=\"1\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_f6PG40Qrdu5e9B1iaIMItPiajABYWA-44.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxqaqPbQprPd4vw8Ytp0cprbzXiakMDdFriaB6B59ibhlBCrNyQFf6PG40Qrdu5e9B1iaIMItPiajABYWA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 245px;height: 245px;\" \/><span style=\"font-family: \u5b8b\u4f53;font-size: 12pt;letter-spacing: 1px;text-align: justify;text-indent: 24pt;\">   <\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009668\" data-ratio=\"0.43741588156123823\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_ZmgFHq12Vdq5ZRv4QfTA7qZmDRPmcQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx70BFaxPVINSwc9b2ILsWVG7uGD5GHHVQo28dpmfF8BQZMSZmgFHq12Vdq5ZRv4QfTA7qZmDRPmcQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"743\" height=\"242.20001220703125\" width=\"553.739990234375\" \/><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 21pt;text-indent: -21pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">\u9898\u76ee\uff1amiR-129-5p \u4f5c\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u75c5\u7406\u5b66\u548c\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u7684\u751f\u7269\u6807\u5fd7\u7269<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 21pt;text-indent: -21pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">\u6742\u5fd7\uff1aAlzheimer’s Research & Therapy<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 21pt;text-indent: -21pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF= 9.0<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 21pt;text-indent: -21pt;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e741\u6708<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);letter-spacing: 1px;\">\u7814\u7a76\u80cc\u666f<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);letter-spacing: 1px;\">\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u662f\u75f4\u5446\u75c7\u7684\u5e38\u89c1\u539f\u56e0\uff0c\u7531\u4e8e\u6d89\u53ca\u590d\u6742\u7684\u795e\u7ecf\u5316\u5b66\u548c\u9057\u4f20\u56e0\u7d20\uff0c\u786e\u5207\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u53d1\u75c5\u673a\u5236\u4ecd\u4e0d\u6e05\u695a\u3002\u5931\u8c03microRNA (miRNA) \u7684\u8868\u8fbe\u662f\u5bfc\u81f4\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u57fa\u56e0\u8868\u8fbe\u53d8\u5316\u7684\u6f5c\u5728\u673a\u5236\u3002miRNA \u662f\u5185\u6e90\u6027\u5355\u94fe RNA \u5206\u5b50\uff0c\u957f\u5ea6\u7ea6\u4e3a 20-23\u4e2a\u6838\u82f7\u9178\uff0c\u4e3b\u8981\u901a\u8fc7\u7ed3\u5408\u7279\u5b9a\u4fe1\u4f7f RNA (mRNA) \u7684 3′-\u975e\u7ffb\u8bd1\u7aef\u6765\u6291\u5236\u5176\u7ffb\u8bd1\u533a\u57df\uff083\u2032-UTR\uff09\u3002\u4e00\u4e9b miRNA \u5df2\u88ab\u786e\u5b9a\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e2d\u5931\u8c03\uff0c\u67d0\u4e9b miRNA \u5728\u5927\u8111\u4e2d\u9ad8\u5ea6\u8868\u8fbe\u3002miRNA \u7684\u5171\u8868\u8fbe\u7f51\u7edc\u548c\u673a\u5668\u5b66\u4e60\u5206\u6790\u53ef\u4ee5\u63d0\u4f9b\u5bf9 AD \u75c5\u7406\u5b66\u548c\u9884\u540e\/\u8bca\u65ad\u751f\u7269\u6807\u5fd7\u7269\u7684\u89c1\u89e3\u3002<\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);letter-spacing: 1px;\">\u6570\u636e\u6765\u6e90<\/span><\/section>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"568\" style=\"border-width: initial;border-style: none;border-color: initial;border-collapse: collapse;width: 100%;\">\n<tbody>\n<tr>\n<td width=\"102\" valign=\"middle\" style=\"width:76.3pt;background:#5B9BD5;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);\">\u6570\u636e\u96c6\/\u961f\u5217<\/span><\/span><\/section>\n<\/td>\n<td width=\"94\" valign=\"middle\" style=\"width:70.85pt;background:#5B9BD5;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);\">\u6570\u636e\u5e93<\/span><\/span><\/section>\n<\/td>\n<td width=\"132\" valign=\"middle\" style=\"width:99.25pt;background:#5B9BD5;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);\">\u6570\u636e\u7c7b\u578b<\/span><\/span><\/section>\n<\/td>\n<td width=\"240\" valign=\"middle\" style=\"width:179.7pt;background:#5B9BD5;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);\">\u8be6\u7ec6\u4fe1\u606f<\/span><\/span><\/section>\n<\/td>\n<\/tr>\n<tr style=\"height:27.95pt;\">\n<td width=\"102\" valign=\"middle\" style=\"width:76.3pt;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:27.95pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-weight: normal;\">GSE157239<\/span><\/span><\/section>\n<\/td>\n<td width=\"94\" valign=\"middle\" style=\"width:70.85pt;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:27.95pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);letter-spacing: 1px;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"132\" valign=\"middle\" style=\"width:99.25pt;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:27.95pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);letter-spacing: 1px;\">RNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"240\" valign=\"middle\" style=\"width:179.7pt;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:27.95pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);\">8\u4e2a\u6ca1\u6709\u8ba4\u77e5\u969c\u788d\u7684\uff08NCI\uff09\u548c8\u4e2aAD\u60a3\u8005<\/span>        <\/span><o:page><\/o:page><\/section>\n<\/td>\n<\/tr>\n<tr style=\"height:27.95pt;\">\n<td width=\"102\" valign=\"middle\" style=\"width:76.3pt;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:27.95pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-weight: normal;letter-spacing: 1px;\">ROS\/MAP cohorts<\/span><\/section>\n<\/td>\n<td width=\"94\" valign=\"middle\" style=\"width:70.85pt;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:27.95pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);letter-spacing: 1px;\">Accelerating Medicines Partnership<\/span><\/section>\n<\/td>\n<td width=\"132\" valign=\"middle\" style=\"width:99.25pt;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:27.95pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);letter-spacing: 1px;\">RNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"240\" valign=\"middle\" style=\"width:179.7pt;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:27.95pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);letter-spacing: 1px;\">102 NCI\u548c177 AD\u60a3\u8005<\/span><\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);letter-spacing: 1px;\">\u7814\u7a76\u601d\u8def<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f7f\u7528\u6765\u81ea\u5b97\u6559\u79e9\u5e8f\u7814\u7a76\u548c Rush \u8bb0\u5fc6\u4e0e\u8870\u8001\u9879\u76ee (ROS\/MAP) (N = 702) \u7684\u8111\u7ec4\u7ec7 miRNA \u56fe\u8c31\u4f5c\u4e3a\u4e00\u9879\u53d1\u73b0\uff0c\u8fdb\u884c\u4e86\u5171\u8868\u8fbe\u7f51\u7edc\u5206\u6790\uff0c\u4ee5\u8bc6\u522b\u4e0e AD\u3001\u5176\u795e\u7ecf\u75c5\u7406\u5b66\u6807\u8bb0\u7269\u548c\u8ba4\u77e5\u76f8\u5173\u7684\u7f51\u7edc\u6a21\u5757\u6570\u636e\u96c6\u3002\u6211\u4eec\u5bf9\u4e2d\u67a2 miRNA \u4e0e AD\u3001\u5176\u795e\u7ecf\u75c5\u7406\u5b66\u6807\u5fd7\u7269\u548c\u8ba4\u77e5\u8fdb\u884c\u4e86\u5173\u8054\u5206\u6790\u3002\u9009\u62e9hub miRNA\u7684\u9776\u57fa\u56e0\u540e\uff0c\u6211\u4eec\u5bf9hub miRNA\u4e0e\u5176\u9776\u57fa\u56e0\u8fdb\u884c\u5173\u8054\u5206\u6790\uff0c\u7136\u540e\u8fdb\u884c\u57fa\u4e8e\u901a\u8def\u7684\u5bcc\u96c6\u5206\u6790\u3002\u4e3a\u4e86\u590d\u5236\uff0c\u6211\u4eec\u4f7f\u7528 ROS\/MAP \u6570\u636e\u96c6\u548c\u6765\u81ea\u57fa\u56e0\u8868\u8fbe\u7efc\u5408\u5e93 (GEO) \u7684\u72ec\u7acb\u6570\u636e\u96c6 (N = 16) \u8fdb\u884c\u4e86\u4e00\u81f4\u7684 miRNA \u5171\u8868\u8fbe\u7f51\u7edc\u5206\u6790\u3002\u6b64\u5916\uff0c\u6211\u4eec\u91c7\u7528\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u6765\u8bc4\u4f30 hub miRNA \u5728 AD \u5206\u7c7b\u4e2d\u7684\u6027\u80fd\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;text-indent: 24pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009669\" data-ratio=\"1.4064171122994653\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_UsLgV94DYKJlib4GDQicMBI8cpwD1A.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx70BFaxPVINSwc9b2ILsWVG4ltwlbWicnJRicaOOsfJpw0LpQ47UsLgV94DYKJlib4GDQicMBI8cpwD1A\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"561\" height=\"631.260009765625\" width=\"448.85003662109375\"><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);\">\u4e3b\u8981\u7ed3\u679c<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><strong><span style=\"background-color: rgb(255, 251, 0);font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">1.miRNA\u5dee\u5f02\u8868\u8fbe\u5206\u6790<\/span><\/strong><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5bf9\u6765\u81ea ROS\/MAP \u7684 177 \u540d AD \u548c 102 \u540d NCI \u53d7\u8bd5\u8005\u4e2d\u7684 309 \u79cd miRNA \u8fdb\u884c\u5dee\u5f02\u8868\u8fbe\u5206\u6790\u3002\u53d1\u73b0 15 \u4e2a miRNA \u4e0e AD\u663e\u8457\u76f8\u5173\uff08\u56fe 1\uff09\uff0cCERAD \u548c Braak \u9633\u6027\u7ec4\u4e2d miR-129-5p \u548c miR-132 \u7684\u8868\u8fbe\u6c34\u5e73\u5747\u663e\u8457\u964d\u4f4e\uff08\u56fe 1\uff09\u3002\u6b64\u5916\uff0cmiR-129-3p\u3001miR-129-5p\u3001miR-132\u3001miR-133b\u3001miR-410\u3001miR-433\u548cmiR-504\u7684\u8868\u8fbe\u6c34\u5e73\u8f83\u9ad8\uff0c\u800cmiR-100\u7684\u8868\u8fbe\u6c34\u5e73\u8f83\u4f4e\u3002\u6b64\u5916\uff0cmiR-129-3p\u3001miR-129-5p \u548c miR-132 \u7684\u8f83\u9ad8\u8868\u8fbe\u6c34\u5e73\u4e0e\u6574\u4f53\u8ba4\u77e5\u80fd\u529b\u7eb5\u5411\u8870\u9000\u7684\u51cf\u6162\u663e\u8457\u76f8\u5173\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009667\" data-ratio=\"0.9797507788161994\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_dXN4BSsrGypCUicVO3kbLjIUp9nqqw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx70BFaxPVINSwc9b2ILsWVGGklZRMRyibpcu3fpia9C3bdfHwLdXN4BSsrGypCUicVO3kbLjIUp9nqqw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"642\" height=\"503.2500305175781\" width=\"513.6500244140625\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u56fe1 miRNA\u4e0e\u8bca\u65ad\u3001\u4e34\u5e8a\u75c5\u7406\u7279\u5f81\u5173\u8054\u5206\u6790\u7ed3\u679c\u70ed\u56fe<\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><strong><span style=\"background-color: rgb(255, 251, 0);font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">2.\u5171\u8868\u8fbe miRNA \u7f51\u7edc\u5206\u6790\u4e0e AD\u3001CERAD\u3001Braak \u548c\u8ba4\u77e5\u76f8\u5173\u7684\u6a21\u5757<\/span><\/strong><\/span><\/section>\n<section style=\"margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6839\u636e 702 \u540d\u53d7\u8bd5\u8005\u7684 miRNA \u8868\u8fbe\u8c31\u4f7f\u7528 WGCNA\u6784\u5efa\u4e86\u65e0\u6807\u5ea6\u5171\u8868\u8fbe\u7f51\u7edc\u3002\u9009\u62e9\u8f6f\u9608\u503c\u529f\u7387\u503c \u03b2 = 4\uff0c\u5e76\u786e\u5b9a\u4e86\u56db\u4e2a\u7f51\u7edc\u6a21\u5757\u3002M3 \u6a21\u5757\u7684 ME \u503c\u8f83\u4f4e\uff0c\u4e0e AD \u548c CERAD \u7684\u663e\u8457\u76f8\u5173\uff0c\u4f46\u4e0e Braak \u9636\u6bb5\u65e0\u5173\u3002\u6b64\u5916\uff0cM3 \u6a21\u5757\u7684 ME \u503c\u8f83\u4f4e\u4e0e\u6700\u540e\u7684\u6574\u4f53\u8ba4\u77e5\u8868\u73b0\u8f83\u4f4e\u76f8\u5173\uff08\u56fe2\uff09\u3002miRNA \u7684\u5bcc\u96c6\u5206\u6790\u663e\u793a\uff0cM3 \u4e0e\u8461\u8404\u7cd6\u4ee3\u8c22\u9ad8\u5ea6\u76f8\u5173\uff0cM1 \u548c M2 \u5206\u522b\u4e0e\u5148\u5929\u514d\u75ab\u548c\u80da\u80ce\u53d1\u80b2\u5bc6\u5207\u76f8\u5173\u3002<\/span>  <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009670\" data-ratio=\"1.3430034129692834\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_TqWeSJbgH4Q8a0kcmyiaV9DB06eK4Q.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx70BFaxPVINSwc9b2ILsWVGm4jDuNwxUAog1eicMoWbStKTSxTqWeSJbgH4Q8a0kcmyiaV9DB06eK4Q\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"586\" height=\"629.6599731445312\" width=\"468.85003662109375\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u56fe2 \u6a21\u5757\u7279\u5f81\u57fa\u56e0\u4e0e\u8bca\u65ad\u53ca\u4e34\u5e8a\u75c5\u7406\u7279\u5f81\u7684\u5173\u8054\u5206\u6790\u7ed3\u679c<\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><strong><span style=\"background-color: rgb(255, 251, 0);font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">3.\u4e0e AD\u3001CERAD\u3001Braak\u548c\u8ba4\u77e5\u76f8\u5173\u7684\u6838\u5fc3miRNA<\/span><\/strong><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5728AD\u76f8\u5173\u7684\u8461\u8404\u7cd6\u4ee3\u8c22\u9014\u5f84\u5bcc\u96c6\u7684M3\u6a21\u5757\u4e2d\uff0c\u57fa\u4e8eTOM\u7684\u6a21\u5757\u5185\u8fde\u63a5\u6027\u6700\u9ad8\u7684\u524d10\u4e2amiRNA\u88ab\u786e\u5b9a\u4e3a\u6838\u5fc3miRNA\uff08\u56fe3\uff09\u3002\u5728\u8fd9 10 \u4e2a miRNA \u4e2d\uff0c miR-129-5p\u4e0e AD\u3001CERAD \u548c Braak \u5448\u8d1f\u76f8\u5173\uff0c\u4e0e\u8ba4\u77e5\u6c34\u5e73\u548c\u53d8\u5316\u76f4\u63a5\u76f8\u5173\u3002miR-433\u548cmiR-221\u7684\u9ad8\u8868\u8fbe\u6c34\u5e73\u4e0eAD\u53d1\u751f\u5448\u8d1f\u76f8\u5173\uff0c\u800c\u53ea\u6709miR-433\u4e0e\u66f4\u597d\u7684\u8ba4\u77e5\u548c\u8f83\u6162\u7684\u8ba4\u77e5\u8870\u9000\u76f8\u5173\uff08\u56fe3\uff09\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0cmiR-200a \u548c miR-1260 \u7684\u9ad8\u8868\u8fbe\u6c34\u5e73\u4e0e AD \u9ad8\u53d1\u751f\u7387\u3001CERAD \u8f83\u9ad8\u548c\u8ba4\u77e5\u80fd\u529b\u8f83\u4f4e\u6709\u5173\uff0c\u4f46\u4e0e Braak \u6216\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u65e0\u5173\u3002\u6700\u540e\uff0cmiR-744 \u4ec5\u4e0e\u8f83\u4f4e\u7684\u6574\u4f53\u8ba4\u77e5\u76f8\u5173\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009671\" data-ratio=\"0.42813765182186236\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_8ckkGm5icNOhjWcbynicthFpmNiaZQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx70BFaxPVINSwc9b2ILsWVGibg8cun9HDNdPDjf0k3QEibhGv8Z88ckkGm5icNOhjWcbynicthFpmNiaZQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"988\" height=\"237.0699920654297\" width=\"553.739990234375\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u56fe3 \u524d10\u4e2a\u5173\u952e\u5019\u9009miRNA\u4e0e\u8bca\u65ad\u53ca\u4e34\u5e8a\u75c5\u7406\u7279\u5f81\u7684\u5173\u8054\u5206\u6790\u7ed3\u679c<\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><strong><span style=\"background-color: rgb(255, 251, 0);font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">4.AD \u76f8\u5173\u5173\u952emiRNA\u7684\u9776\u57fa\u56e0<\/span><\/strong><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u4ece miRDB \u548c TargetScan \u6570\u636e\u5e93\u4e2d\u83b7\u5f97\u4e86 5 \u4e2a AD \u76f8\u5173\u5173\u952emiRNA\uff08miR-129-5p\u3001miR-433\u3001miR-1260\u3001miR-200a \u548c miR-221\uff09\u7684\u9776\u57fa\u56e0\u3002RNA-Seq \u6570\u636e\u5206\u6790\u786e\u5b9a 189\u3001101\u3001310\u3001591 \u548c 73 \u4e2a\u9776\u57fa\u56e0\u5206\u522b\u4e0e miR-129-5p\u3001miR-433\u3001miR-1260\u3001miR-200a \u548c miR-221 \u76f8\u5e94 miRNA \u7684\u8868\u8fbe\u6c34\u5e73\u663e\u8457\u76f8\u5173\u3002\u6b64\u5916\uff0cRNA-Seq \u6570\u636e\u5206\u6790\u786e\u5b9a\u4e86\u603b\u5171 22\u30013\u300112\u300130 \u548c 25 \u4e2a\u5206\u522b\u4e0e AD \u663e\u8457\u76f8\u5173\u7684\u9776\u57fa\u56e0\uff08miR-129-5p\u3001miR-433\u3001miR-1260\u3001miR-200a \u548c miR- 221\uff09\u3002<\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><strong><span style=\"background-color: rgb(255, 251, 0);font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">5.\u57fa\u4e8e\u901a\u8def\u7684\u9776\u57fa\u56e0\u5bcc\u96c6\u5206\u6790<\/span><\/strong><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">KEGG\u901a\u8def\u7684\u5bcc\u96c6\u5206\u6790\u663e\u793a\uff0c\u901a\u8fc7RNA-Seq\u5206\u6790\u9274\u5b9a\u51fa\u76845\u4e2aAD\u76f8\u5173\u5173\u952emiRNA\u7684\u9776\u57fa\u56e0\u4e3b\u8981\u6d89\u53ca\u4ee5\u4e0b\u901a\u8def\uff1a\u8f74\u7a81\u5f15\u5bfc\u3001ErbB\u4fe1\u53f7\u901a\u8def\u3001MAPK\u4fe1\u53f7\u901a\u8def\uff0c\u03b3-\u6c28\u57fa\u4e01\u9178\u9178\u80fd\u7a81\u89e6\u3001\u81ea\u566c\u3001AMPK\u3001mTOR\u4fe1\u53f7\u901a\u8def\u548c\u8c37\u6c28\u9178\u7a81\u89e6\u3002\u57fa\u4e8eGO-BP\u901a\u8def\u7684\u5bcc\u96c6\u5206\u6790\u8868\u660e\uff0c\u901a\u8fc7RNA-Seq\u9274\u5b9a\u51fa\u76ee\u6807\u57fa\u56e0\u5bf9 5 \u4e2a AD \u76f8\u5173\u4e2d\u67a2 miRNA \u7684\u5206\u6790\u5bcc\u542b\u4ee5\u4e0b\u9014\u5f84\uff1a\u86cb\u767d\u8d28\u78f7\u9178\u5316\u3001\u795e\u7ecf\u7cfb\u7edf\u53d1\u80b2\u3001\u67d3\u8272\u8d28\u7ec4\u7ec7\u548c\u795e\u7ecf\u5143\u8fc1\u79fb\u3002 <\/span>  <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><strong><span style=\"background-color: rgb(255, 251, 0);font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">6.\u6765\u81ea\u4e24\u4e2a\u72ec\u7acb\u6570\u636e\u96c6\u7684 miRNA \u56fe\u8c31\u8fdb\u884c\u5171\u8bc6\u7f51\u7edc\u5206\u6790<\/span><\/strong><\/span><\/section>\n<section style=\"margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u9009\u62e9\u5171\u8868\u8fbe\u6a21\u5757\u4e2d\u7684\u5173\u952e miRNA \u6765\u8bc4\u4f30\u72ec\u7acb\u6570\u636e\u96c6\u4e2d ROS\/MAP \u6570\u636e\u96c6\u4e2d\u786e\u5b9a\u7684 5 \u4e2a AD \u76f8\u5173\u5173\u952e miRNA \u7684\u590d\u5236\u60c5\u51b5\u3002<\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><strong><span style=\"background-color: rgb(255, 251, 0);font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">7.\u5171\u8bc6\u7f51\u7edc\u6a21\u5757\u8bc6\u522b<\/span><\/strong><\/span><\/section>\n<section style=\"margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u5bf9\u53d1\u73b0\u548c\u590d\u5236\u6570\u636e\u96c6\u5206\u522b\u6267\u884cmiRNA\u5171\u8868\u8fbe\u7f51\u7edc\u7684\u6784\u5efa\uff0c\u5e76\u4f7f\u7528\u5e73\u5747\u8fde\u9501\u5c42\u6b21\u805a\u7c7b\u65b9\u6cd5\u4e2d\u7684\u5171\u8bc6\u76f8\u5f02\u6027\u5ea6\u91cf\u6765\u8bc6\u522b\u5171\u8bc6\u6a21\u5757\u3002\u9009\u62e9\u03b2 = 4 \u7684\u8f6f\u9608\u503c\uff0c\u5e76\u786e\u5b9a\u4e86\u56db\u4e2a\u5171\u8bc6\u6a21\u5757\uff08\u56fe4\uff09\u3002\u6240\u6709\u5171\u8bc6\u6a21\u5757\u5728\u4e24\u4e2a\u6570\u636e\u96c6\u4e2d\u90fd\u6709\u5bf9\u5e94\u7684\u6a21\u5757\uff0c\u8868\u660e\u4e24\u4e2a\u6570\u636e\u96c6\u4e2d\u7684\u5171\u8bc6\u6a21\u5757\u7ed3\u6784\u76f8\u4f3c\uff08\u56fe4\uff09\u3002miRNA \u7ec4\u6210\u7684\u5171\u8bc6 CM0 \u6a21\u5757\u672a\u5206\u914d\u7ed9\u5176\u4ed6\u6a21\u5757\u3002<\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009672\" data-ratio=\"0.6166666666666667\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_w1eAAN70MufUfd5D2De7AHmTVGaibQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx70BFaxPVINSwc9b2ILsWVGwPuOsvFjE3kFhUyQArTKhJKcPw1eAAN70MufUfd5D2De7AHmTVGaibQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"200.1400146484375\" width=\"324.54998779296875\" \/><\/span><span style=\"letter-spacing: 1px;font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\"> <img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009673\" data-ratio=\"0.9805555555555555\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_o568gbia5LcP2ANSmWVVkRhMBAmGMg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx70BFaxPVINSwc9b2ILsWVGHtdtkKPGtRLiah3FicwaRU1BoK2o568gbia5LcP2ANSmWVVkRhMBAmGMg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"196.64996337890625\" width=\"200.510009765625\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u56fe4 \u5171\u8bc6\u7f51\u7edc\u6a21\u5757\u7684\u8bc6\u522b<\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><strong><span style=\"background-color: rgb(255, 251, 0);font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">8.\u5171\u8bc6\u6a21\u5757\u7684\u4fdd\u5b58<\/span><\/strong><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u6784\u5efa\u4e86\u5171\u8bc6 ME \u7f51\u7edc\u6765\u7814\u7a76\u6a21\u5757\u7684\u8868\u8fbe\u6a21\u5f0f\u662f\u5426\u5f7c\u6b64\u76f8\u5173\uff08\u56fe 5A\u3001B\uff09\u3002\u8fdb\u4e00\u6b65\u6784\u5efa\u4e86\u53d1\u73b0\u6570\u636e\u96c6\u548c\u590d\u5236\u6570\u636e\u96c6\u4e4b\u95f4\u5171\u8bc6 ME \u5bf9\u4e4b\u95f4\u76f8\u5173\u6027\u7684\u4fdd\u5b58\u7f51\u7edc\uff0c\u4ee5\u4e86\u89e3\u4e24\u4e2a\u6570\u636e\u96c6\u4fdd\u5b58\u6a21\u5f0f\u7684\u53d8\u5316\uff08\u56fe 5C\uff09\u3002\u4e24\u4e2a\u7f51\u7edc\u4e2d\u6240\u6709\u5171\u8bc6 ME \u5bf9\u4e4b\u95f4\u7684\u4fdd\u5b58\u7f51\u7edc D \u503c\u4e3a 0.88\uff08\u56fe 5D\uff09\uff0c\u8868\u660e\u8fd9\u4e9b\u6a21\u5757\u5728\u4e24\u4e2a\u72ec\u7acb\u7684\u8868\u8fbe\u6a21\u5f0f\u4e2d\u5f97\u5230\u4e86\u5f88\u597d\u7684\u4fdd\u5b58\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009674\" data-ratio=\"0.3534136546184739\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_6vOLqHnDtzZTgARbok9twVeficu4pA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx70BFaxPVINSwc9b2ILsWVG2ib4s6uZrFXzfwjGAGcSgVkYwY6vOLqHnDtzZTgARbok9twVeficu4pA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"996\" height=\"195.66998291015625\" width=\"553.739990234375\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u56fe5 \u5171\u8bc6\u6a21\u5757\u7279\u5f81\u57fa\u56e0\u7f51\u7edc\u7684\u6784\u5efa<\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><strong><span style=\"background-color: rgb(255, 251, 0);font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">9.\u8de8\u4e24\u4e2a\u72ec\u7acb\u6570\u636e\u96c6\u8bc6\u522b AD \u76f8\u5173\u5171\u8bc6\u6a21\u5757\u4ee5\u53ca AD \u76f8\u5173\u5173\u952e miRNA \u7684\u590d\u5236<\/span><\/strong><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe 6 \u663e\u793a\u4e86\u6a21\u5757\u4e34\u5e8a\u7279\u5f81\u70ed\u56fe\uff0c\u8868\u660e AD \u4e0e\u4e24\u4e2a\u72ec\u7acb\u6570\u636e\u96c6\u4e2d\u7684\u56db\u4e2a\u5171\u8bc6\u6a21\u5757\u4e4b\u95f4\u7684\u5173\u8054\u3002\u5171\u8bc6 CM2 \u548c CM3 \u6a21\u5757\u7684\u4f4e ME \u503c\u4e0e ROS\/MAP \u6570\u636e\u96c6\u4e2d\u7684 AD \u663e\u8457\u76f8\u5173\u3002\u5728 GEO \u6570\u636e\u96c6\u4e2d\uff0c\u867d\u7136\u5171\u8bc6\u7684 ME \u503c\u4e4b\u95f4\u7684\u5173\u8054CM2\u548cCM3\u6a21\u5757\u4e0eAD\u4e0d\u663e\u8457\uff0c\u6548\u5e94\u5927\u5c0f\u548c\u5173\u8054\u65b9\u5411\u4e0eROS\/MAP\u6570\u636e\u96c6\u4e2d\u4e00\u81f4\u3002\u5728\u53d1\u73b0\u6570\u636e\u96c6 (ROS\/MAP) \u4e2d\u786e\u5b9a\u7684 5 \u4e2a\u4e0e AD \u76f8\u5173\u7684\u4e2d\u67a2 miRNA \u4e2d\uff0cmiR-129-5p\u3001miR-221 \u548c miR-200a \u5305\u542b\u5728 CM2 \u6a21\u5757\u4e2d\u3002\u76f8\u5173\u6027\u5206\u6790\u8868\u660e\uff0cROS\/MAP \u6570\u636e\u96c6\u4e2d\u7684 M3 \u6a21\u5757\u4e0e ROS\/MAP \u548c GEO \u7ec4\u5408\u6570\u636e\u96c6\u4e2d\u7684\u5171\u8bc6 CM2 \u6a21\u5757\u5177\u6709\u5f88\u5f3a\u7684\u76f8\u5173\u6027\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009675\" data-ratio=\"0.6099585062240664\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_XBvjD7n1zP6uFglERfibI5Kp1ic3Xg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx70BFaxPVINSwc9b2ILsWVGxys4YUmNQq0KXziaEQDApkuX9l9XBvjD7n1zP6uFglERfibI5Kp1ic3Xg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"723\" height=\"337.739990234375\" width=\"553.739990234375\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe6 \u5171\u8bc6\u6a21\u5757\u7279\u5f81\u57fa\u56e0\u4e0e ROS\/MAP \u961f\u5217\u3001GEO (GSE157239) \u961f\u5217\u4e2d\u8bca\u65ad\u7684\u5173\u8054\u5206\u6790\u7ed3\u679c<\/span><span style=\"font-size: 12pt;text-indent: 0pt;\">\u4ee5\u53ca\u8de8 ROS\/MAP \u548c GEO \u6570\u636e\u96c6<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><strong><span style=\"background-color: rgb(255, 251, 0);font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;\">10.AD \u5206\u7c7b\u7684\u673a\u5668\u5b66\u4e60\u5206\u6790<\/span><\/strong><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f7f\u7528\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u4e2d\u7684\u60e9\u7f5a\u903b\u8f91\u56de\u5f52\u5bf9 NCI \u7684 AD \u8fdb\u884c\u5206\u7c7b\u7528\u4e8e\u8bc4\u4f30\u4e94\u79cd\u4e0d\u540c\u7684\u5206\u7c7b\u6a21\u578b\u300210 \u500d\u4ea4\u53c9\u9a8c\u8bc1\u7684\u7ed3\u679c\u5982\u56fe 7 \u6240\u793a\u3002\u6a21\u578b 1\uff08\u5305\u62ec\u5e74\u9f84\u3001\u6027\u522b\u548c APOE \u03b54 \u643a\u5e26\u8005\u72b6\u6001\uff09\u7684\u5e73\u5747 AUC \u503c\u4e3a 0.807\uff08\u56fe 7A\uff09\u3002\u901a\u8fc7\u5728\u6a21\u578b 1 \u4e2d\u6dfb\u52a0 5 \u4e2a AD \u76f8\u5173\u5173\u952emiRNA \u83b7\u5f97\u7684\u6a21\u578b 3 \u7684\u5e73\u5747 AUC \u503c\u663e\u8457\u589e\u52a0\u81f3 0.870\uff08\u56fe 7C\uff09\uff0c\u4e0e\u6a21\u578b 5 \u76f8\u5f53\uff08\u56fe 7E\uff09\u3002\u4ec5\u5305\u62ec\u4e94\u4e2a\u4e0e AD \u76f8\u5173\u7684\u5173\u952e miRNA\u7684\u6a21\u578b 2 \u7684\u5e73\u5747 AUC \u503c\u4e3a0.740\uff0c\u6a21\u578b 4\uff08\u5305\u62ec\u6240\u6709 309 \u4e2a miRNA\uff09AUC \u503c\u4e3a 0.815\uff08\u56fe 7B\u3001D\uff09\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009676\" data-ratio=\"0.650049850448654\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_1eJLzSornb4td8tEJ00pEuh106K5Fw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx70BFaxPVINSwc9b2ILsWVGFCBuQYVmuog2Fjt32lh0aPG81eJLzSornb4td8tEJ00pEuh106K5Fw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1003\" height=\"359.94000244140625\" width=\"553.739990234375\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe7 \u4f7f\u7528\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u4e2d\u60e9\u7f5a\u903b\u8f91\u56de\u5f52\u7684ROC\u66f2\u7ebf\u548c\u5e73\u5747AUC<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u8fd9\u7bc7\u6587\u7ae0\u6574\u5408\u7f51\u7edc\u548c\u673a\u5668\u5b66\u4e60\u5206\u6790\u8bc6\u522b\u4e86miRNA\u795e\u7ecf\u75c5\u7406\u5b66\u6807\u5fd7\u7269miR-129-5p\uff0c\u4e0eAD\u548c\u8ba4\u77e5\u76f8\u5173\uff0c\u8fd9\u4e00\u53d1\u73b0\u589e\u5f3a\u4e86\u5bf9AD\u53d1\u75c5\u673a\u5236\u7684\u7406\u89e3\uff0c\u5bf9AD\u5206\u7c7b\u548c\u4f5c\u4e3a\u6f5c\u5728\u7684\u8bca\u65ad\/\u9884\u540e\u751f\u7269\u6807\u5fd7\u7269\u6709\u5f88\u5927\u7684\u5e2e\u52a9\uff0c\u4f46\u662f\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u6765\u9a8c\u8bc1\u548c\u9610\u660e\u5176\u6f5c\u5728\u7684\u673a\u5236\u3002<\/span><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u53ea\u7528\u751f\u4fe1\u5206\u6790\u5c31\u80fd\u5b8c\u6210\u4e00\u7bc78\u5206+\u7684\u7eaf\u6570\u636e\u5206\u6790\u6587\u7ae0\uff0c\u540c\u5b66\u4eec\u53ea\u9700\u8981\u5b66\u4f1a\u201c\u5171\u8868\u8fbe\u7f51\u7edc+\u673a\u5668\u5b66\u4e60\u201d\u7684\u65b9\u6cd5\uff0c\u6362\u4e2a\u75be\u75c5\u5bfb\u627e\u5b83\u7684\u6807\u5fd7\u7269\u53ed\uff01<\/span><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(255, 0, 0);font-weight: bold;\">\u60f3\u590d\u73b0\u7684\u6293\u7d27\u626b\u7801\u8054\u7cfb\u9986\u957f\u5427~<\/span><span style=\"font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">~<\/span><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><br \/><\/section>\n<section style=\"text-indent: 0px;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"color: rgb(0, 122, 170);letter-spacing: 1px;\"><strong><span style=\"color: rgb(0, 122, 170);text-indent: 32px;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/section>\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><br \/><\/section>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017473\" data-ratio=\"1\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_B2jkicacLzPjw4xMSqVvoucZjonVDA-4.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><span style=\"letter-spacing: 1px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n<p style=\"margin-bottom: 2px;\"><span style=\"letter-spacing: 1px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n<p><span style=\"letter-spacing: 1px;\"><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100017513\" data-ratio=\"0.7621359223300971\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/14_XiafCUEp1NqZoBA3F9mvRcJR4PQ1Tw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAyZkFgOs95yxYHqY7n8a8k4wWKhXgwQvZVTwDhgYYDDu7asGXiafCUEp1NqZoBA3F9mvRcJR4PQ1Tw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"618\" style=\"\" \/><span style=\"font-size: var(--articleFontsize);letter-spacing: 0.034em;\"><\/span><\/p>\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><span style=\"letter-spacing: 1px;\"><strong>\u5f80\u671f\u56de\u987e<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"letter-spacing: 1px;\"><strong>01<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);letter-spacing: 1px;\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"letter-spacing: 1px;\"><strong>02<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);letter-spacing: 1px;\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"letter-spacing: 1px;\"><strong>03<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);letter-spacing: 1px;\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"letter-spacing: 1px;\"><strong>04<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);letter-spacing: 1px;\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" 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powered-by=\"xiumi.us\">\n<section>\n<section>\n<section powered-by=\"xiumi.us\">\n<section>\n<section powered-by=\"xiumi.us\">\n<section><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"display: none;margin-bottom: 24px;margin-top: 8px;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/section>\n<\/section>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6bd5\u4e1a\u5c31\u9760\u5b83\u4e86\uff01\u673a\u5668\u5b66\u4e60+\u5171\u8868\u8fbe\u7f51\u7edc\uff0c\u8ba9miRNA\u6d4b\u5e8f\u6570\u636e\u5f00\u51fa\u65b0\u7684\u9053\u8def\uff01\u7eaf\u751f\u4fe1\u4e5f\u80fd\u53d19\u5206+\uff01 \u9986\u957f & […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/55165"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=55165"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/55165\/revisions"}],"predecessor-version":[{"id":55180,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/55165\/revisions\/55180"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=55165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=55165"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=55165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}