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style=\"transform: rotateZ(60deg);\" powered-by=\"xiumi.us\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;\">\n<section style=\"width: 100%;height: 5px;background-color: rgb(255, 255, 255);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 34px;align-self: flex-start;flex: 0 0 auto;height: auto;overflow: hidden;margin-right: -17px;\">\n<section style=\"transform: rotateZ(60deg);\" powered-by=\"xiumi.us\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;\">\n<section style=\"width: 100%;height: 5px;background-color: rgb(201, 229, 70);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 34px;align-self: flex-start;flex: 0 0 auto;height: auto;overflow: hidden;\">\n<section style=\"transform: rotateZ(60deg);\" powered-by=\"xiumi.us\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;\">\n<section style=\"width: 100%;height: 5px;background-color: rgb(255, 255, 255);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<h1><\/h1>\n<h1><\/h1>\n<h1><\/h1>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<h1><strong><span style=\"color: rgb(2, 30, 170);\">\u5341\u5206\u949f\u8be6\u89e3\u5e8f\u5217\u6bd4\u5bf9\u539f\u7406<\/span><\/strong><o:p><\/o:p><\/h1>\n<p>\u4e0a\u4e00\u6b21\u5c0f\u82b1\u7ed9\u5927\u5bb6\u4ed4\u7ec6\u5206\u4eab\u4e86\u5e8f\u5217\u6bd4\u5bf9\u7684\u8be6\u7ec6\u8fc7\u7a0b\u5e76\u4e14\u6bcf\u4e00\u6b65\u90fd\u505a\u4e86\u5145\u5206\u7684\u8bf4\u660e\uff0c\u60f3\u5fc5\u5c0f\u4f19\u4f34\u4eec\u90fd\u662f\u6536\u83b7\u6ee1\u6ee1\uff0c\u8feb\u4e0d\u53ca\u5f85\u5730\u60f3\u5b66\u4e60\u5e8f\u5217\u6bd4\u5bf9\u7684\u539f\u7406\u4e86\u5427\uff01\u8fd9\u4e00\u6b21\u5c0f\u82b1\u5c31\u6765\u5206\u4eab\u5e8f\u5217\u6bd4\u5bf9\u7684\u539f\u7406\uff0c\u5e72\u8d27\u6ee1\u6ee1\u7684\u540c\u65f6\u53ef\u80fd\u4f1a\u7a0d\u5fae\u6709\u4e00\u70b9\u96be\u5ea6\uff0c\u4f46\u662f\u60f3\u8981\u6210\u4e3a\u751f\u4fe1\u5927\u795e\uff0c\u5c0f\u4f19\u4f34\u4eec\u5c31\u4e0d\u80fd\u4e0d\u4e86\u89e3\u8be6\u7ec6\u7684\u539f\u7406\u54e6~\u5e9f\u8bdd\u4e0d\u591a\u8bf4\uff0c\u6211\u4eec\u76f4\u63a5\u5f00\u59cb\u5427\uff01<o:p><\/o:p><\/p>\n<h2><br 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src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_at554nlnGhTOs4jkFLFhvgY5IXEhbQ-9.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSLagtksYRLUn1j2c9AKmIvpuGiat554nlnGhTOs4jkFLFhvgY5IXEhbQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"242\" style=\"\" \/><\/p>\n<p style=\"text-align: center;\"><br \/><\/p>\n<\/section>\n<p>\u5728\u8fd9\u79cd\u5bf9\u9f50\u65b9\u5f0f\u4e0b\uff0c\u7b2c\u4e00\u6761\u5e8f\u5217\u4e0a\u6709\u4e00\u4e2a\u78b1\u57faT\u5728\u7b2c\u4e8c\u6761\u5e8f\u5217\u4e0a\u53d8\u6210\u4e86\u78b1\u57faA\uff1b\u7b2c\u4e8c\u6761\u5e8f\u5217\u4e2d\u591a\u4e86\u4e00\u4e2aT\uff0c\u901a\u8fc7\u5728\u7b2c\u4e00\u6761\u5e8f\u5217\u4e2d\u6dfb\u52a0\u4e00\u4e2a\u201c\u7a7a\u683c\u201d\uff0c\u4f7f\u4e24\u6761\u5e8f\u5217\u91cd\u65b0\u5bf9\u9f50\u3002<br \/><\/p>\n<p>\u5982\u4f55\u8bc4\u4ef7\u5e8f\u5217\u6bd4\u5bf9\u7ed3\u679c\uff1f\u6362\u53e5\u8bdd\u8bb2\uff0c\u5982\u4f55\u91cf\u5316\u4e24\u6761\u88ab\u6bd4\u8f83\u5e8f\u5217\u7684\u76f8\u4f3c\u7a0b\u5ea6\uff1f\u8fd9\u91cc\u5f15\u5165\u4e00\u4e2a\u6982\u5ff5<strong>\uff1a\u5e8f\u5217\u4e00\u81f4\u6027<\/strong>\uff0c\u5176\u6570\u503c\u4ee3\u8868\u8fdb\u884c\u5e8f\u5217\u6bd4\u5bf9\u65f6\uff0c\u6240\u9009\u5e8f\u5217\u5f53\u4e2d\uff0c<strong>\u76f8\u540c\u4f4d\u70b9\u7684\u78b1\u57fa\u5b8c\u5168\u4e00\u81f4\u7684\u6570\u91cf\u5360\u603b\u78b1\u57fa\u6570\u7684\u6bd4\u4f8b<\/strong>\u3002\u5e8f\u5217\u4e00\u81f4\u6027\u6700\u9ad8100%\uff0c\u6b64\u65f6\u8868\u793a\u5e8f\u5217\u5b8c\u5168\u4e00\u81f4\u3002\u5728\u4e0a\u9762\u7684\u4f8b\u5b50\u5f53\u4e2d\uff0c\u4e24\u6761\u5e8f\u5217\u7684\u4e00\u81f4\u6027\u4e3a9\/11*100%=81.82%\uff08\u7b97\u4e0a\u8865\u9f50\u7684-\u6bcf\u6761\u5e8f\u521711\u4e2a\u78b1\u57fa\uff0c\u4ece\u5de6\u5f80\u53f3\u7684\u7b2c\u4e09\u4e2a\u548c\u7b2c\u516b\u4e2a\u78b1\u57fa\u5bf9\u9f50\u5931\u8d25\uff0c\u5171\u4e5d\u4e2a\u5bf9\u9f50\u6210\u529f\uff09\u3002<o:p><\/o:p><\/p>\n<p><strong>\u5e8f\u5217\u6bd4\u5bf9\u7684\u5e38\u89c1\u7c7b\u578b<\/strong>\uff1a<o:p><\/o:p><\/p>\n<p>\u6839\u636e<strong>\u6bd4\u5bf9\u8303\u56f4<\/strong>\u4e0d\u540c\uff0c\u6709\u4e24\u79cd\u7c7b\u578b\u7684\u5bf9\u9f50\u65b9\u5f0f\uff1a<o:p><\/o:p><\/p>\n<p>1. <strong>\u5168\u5c40\u6bd4\u5bf9<\/strong>\uff1a\u5168\u5c40\u6bd4\u5bf9\u662f<strong>\u5c06\u6574\u4e2a\u67e5\u8be2\u5e8f\u5217\u4e0e\u53c2\u8003\u5e8f\u5217\u8fdb\u884c\u6bd4\u5bf9\uff0c\u76ee\u6807\u662f\u627e\u5230\u4e24\u4e2a\u5e8f\u5217\u4e4b\u95f4\u7684\u6700\u4f18\u5339\u914d<\/strong>\u3002\u5168\u5c40\u6bd4\u5bf9\u9002\u7528\u4e8e\u5177\u6709\u76f8\u5bf9\u8f83\u9ad8\u7684\u76f8\u4f3c\u6027\u4e14\u8f83\u957f\u7684\u5e8f\u5217\uff0c\u4f8b\u5982\u6bd4\u5bf9\u6574\u4e2a\u57fa\u56e0\u7ec4\u6216\u5168\u957f cDNA \u5e8f\u5217\u3002\u5e38\u7528\u7684\u5168\u5c40\u6bd4\u5bf9\u7b97\u6cd5\u5305\u62ec Needleman-Wunsch \u7b97\u6cd5\u548c Smith-Waterman \u7b97\u6cd5\u3002\u5168\u5c40\u6bd4\u5bf9\u4f1a\u8003\u8651\u6574\u4e2a\u5e8f\u5217\u7684\u5339\u914d\u3001\u66ff\u4ee3\u548c\u63d2\u5165\/\u5220\u9664\u4fe1\u606f\uff0c\u56e0\u6b64\u80fd\u591f\u53d1\u73b0\u8f83\u8fdc\u7684\u4eb2\u7f18\u5173\u7cfb\u548c\u6f14\u5316\u4fe1\u606f\uff0c\u4f46\u8ba1\u7b97\u6210\u672c\u8f83\u9ad8\u3002<o:p><\/o:p><\/p>\n<p>2<strong>. \u5c40\u90e8\u6bd4\u5bf9<\/strong>\uff1a\u5c40\u90e8\u6bd4\u5bf9\u662f<strong>\u5bfb\u627e\u4e24\u4e2a\u5e8f\u5217\u4e2d\u7684\u4e00\u4e2a\u6216\u591a\u4e2a\u7247\u6bb5\u7684\u6700\u4f18\u5339\u914d<\/strong>\u3002\u5c40\u90e8\u6bd4\u5bf9\u9002\u7528\u4e8e\u5177\u6709\u8f83\u5c0f\u7684\u7247\u6bb5\u6216\u5b58\u5728\u63d2\u5165\/\u5220\u9664\u7684\u60c5\u51b5\uff0c\u4f8b\u5982\u6bd4\u5bf9\u5df2\u77e5\u86cb\u767d\u8d28\u7ed3\u6784\u4e2d\u7684\u5c0f\u7247\u6bb5\u6216\u627e\u5230\u57fa\u56e0\u7ec4\u4e2d\u7684\u91cd\u590d\u5e8f\u5217\u3002\u5e38\u7528\u7684\u5c40\u90e8\u6bd4\u5bf9\u7b97\u6cd5\u662f Smith-Waterman \u7b97\u6cd5\u3002\u5c40\u90e8\u6bd4\u5bf9\u5c06\u91cd\u70b9\u653e\u5728\u6700\u4f73\u5339\u914d\u7247\u6bb5\u4e0a\uff0c\u56e0\u6b64\u53ef\u4ee5\u68c0\u6d4b\u5230\u66f4\u5c0f\u7684\u4eb2\u7f18\u5173\u7cfb\u548c\u6f14\u5316\u4fe1\u606f\uff0c\u4f46\u8ba1\u7b97\u6210\u672c\u4e5f\u4e0d\u4f4e\u3002<o:p><\/o:p><\/p>\n<p>\u4e00\u822c\u6765\u8bf4\uff0c\u5168\u5c40\u6bd4\u5bf9\u9002\u7528\u4e8e\u8f83\u957f\u7684\u5e8f\u5217\u4e14\u76f8\u4f3c\u6027\u8f83\u9ad8\u7684\u6bd4\u5bf9\uff0c\u80fd\u591f\u63d0\u4f9b\u66f4\u5168\u9762\u7684\u4fe1\u606f\uff0c\u4f46\u8ba1\u7b97\u6210\u672c\u8f83\u9ad8\u3002\u800c\u5c40\u90e8\u6bd4\u5bf9\u9002\u7528\u4e8e\u8f83\u77ed\u7247\u6bb5\u6216\u5b58\u5728\u53d8\u5f02\u7684\u6bd4\u5bf9\uff0c\u53ef\u4ee5\u66f4\u51c6\u786e\u5730\u627e\u5230\u6700\u4f73\u5339\u914d\uff0c\u4f46\u53ef\u80fd\u4f1a\u9519\u8fc7\u5168\u5c40\u7684\u6f14\u5316\u4fe1\u606f\u3002\u76f8\u5bf9\u4e8e\u5168\u5c40\u6bd4\u5bf9\u548c\u5c40\u90e8\u6bd4\u5bf9\uff0cSeed-and-Extend\uff08\u79cd\u5b50\u6269\u5c55\uff09\u6bd4\u5bf9\u65b9\u6cd5\u53ef\u4ee5\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u964d\u4f4e\u8ba1\u7b97\u6210\u672c\uff0c\u5b83\u7684\u57fa\u672c\u539f\u7406\u662f\u9996\u5148\u901a\u8fc7\u5feb\u901f\u7684\u79cd\u5b50\u5339\u914d\u8fc7\u7a0b\u627e\u5230\u4e00\u7ec4\u53ef\u80fd\u7684\u5339\u914d\u4f4d\u7f6e\uff0c\u7136\u540e\u5728\u8fd9\u4e9b\u4f4d\u7f6e\u5468\u56f4\u8fdb\u884c\u6269\u5c55\u4ee5\u5bfb\u627e\u6700\u4f73\u5339\u914d\u3002\u9650\u4e8e\u7bc7\u5e45\u5c0f\u82b1\u5728\u8fd9\u91cc\u5c31\u4e0d\u5c55\u5f00\u8bb2\u89e3\u4e86\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u4eec\u53ef\u4ee5\u81ea\u884c\u4e86\u89e3\u54e6~<o:p><\/o:p><\/p>\n<p>\u800c\u6839\u636e\u53c2\u4e0e<strong>\u6bd4\u5bf9\u5e8f\u5217\u7684\u6570\u91cf<\/strong>\uff0c\u4e5f\u6709\u4e24\u79cd\u4e0d\u540c\u7684\u6bd4\u5bf9\u65b9\u5f0f\uff1a<o:p><\/o:p><\/p>\n<p>1. <strong>\u6210\u5bf9\u6bd4\u5bf9<\/strong>\uff1a\u6210\u5bf9\u6bd4\u5bf9\u662f\u6307<strong>\u5c06\u6210\u5bf9\u7684\u6d4b\u5e8f\u8bfb\u6bb5\u540c\u65f6\u4e0e\u53c2\u8003\u5e8f\u5217\u8fdb\u884c\u6bd4\u5bf9<\/strong>\u3002\u5728\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u4e2d\uff0c\u901a\u5e38\u4f1a\u5bf9DNA\u6216RNA\u6837\u672c\u8fdb\u884c\u53cc\u7aef\u6d4b\u5e8f\uff0c\u751f\u6210\u4e24\u4e2a\u76f8\u4e92\u5bf9\u5e94\u7684\u6d4b\u5e8f\u8bfb\u6bb5\uff08Paired-End Reads\uff09\u3002\u6210\u5bf9\u6bd4\u5bf9\u7684\u76ee\u7684\u662f\u5c06\u8fd9\u4e24\u4e2a\u6d4b\u5e8f\u8bfb\u6bb5\u540c\u65f6\u5bf9\u9f50\u5230\u53c2\u8003\u5e8f\u5217\u4e0a\uff0c\u4ee5\u5bfb\u627e\u6700\u4f73\u5339\u914d\u4f4d\u7f6e\u3002<strong>\u6210\u5bf9\u6bd4\u5bf9\u80fd\u591f\u63d0\u4f9b\u66f4\u51c6\u786e\u7684\u6bd4\u5bf9\u7ed3\u679c<\/strong>\uff0c\u53ef\u4ee5\u5e2e\u52a9\u89e3\u51b3\u63d2\u5165\u7247\u6bb5\u3001\u7ed3\u6784\u53d8\u5f02\u7b49\u95ee\u9898\uff0c\u5e76\u63d0\u9ad8\u4e86\u7ed3\u6784\u6ce8\u91ca\u548c\u53d8\u5f02\u68c0\u6d4b\u7684\u51c6\u786e\u6027\u3002<o:p><\/o:p><\/p>\n<p>2.<strong> \u591a\u91cd\u6bd4\u5bf9<\/strong>\uff1a\u591a\u91cd\u6bd4\u5bf9\u662f<strong>\u6307\u5c06\u591a\u4e2a\u5e8f\u5217\u540c\u65f6\u8fdb\u884c\u6bd4\u5bf9\uff0c\u4ee5\u627e\u5230\u5b83\u4eec\u4e4b\u95f4\u7684\u5171\u540c\u6a21\u5f0f\u548c\u5171\u4eab\u7279\u5f81<\/strong>\u3002\u591a\u91cd\u6bd4\u5bf9\u901a\u5e38\u7528\u4e8e\u6bd4\u8f83\u591a\u4e2a\u76f8\u5173\u5e8f\u5217\uff08\u5982\u86cb\u767d\u8d28\u5e8f\u5217\u3001DNA\u5e8f\u5217\u6216RNA\u5e8f\u5217\uff09\u7684\u76f8\u4f3c\u6027\u548c\u5dee\u5f02\u6027\u3002\u901a\u8fc7\u591a\u91cd\u6bd4\u5bf9\uff0c\u53ef\u4ee5\u8bc6\u522b\u51fa\u5e8f\u5217\u4e4b\u95f4\u7684\u4fdd\u5b88\u533a\u57df\u3001\u53d8\u5f02\u4f4d\u70b9\u3001\u63d2\u5165\/\u5220\u9664\u4e8b\u4ef6\u7b49\u4fe1\u606f\uff0c\u4ece\u800c\u63a8\u65ad\u5e8f\u5217\u7684\u8fdb\u5316\u5173\u7cfb\u6216\u529f\u80fd\u7279\u5f81\u3002\u5e38\u7528\u7684\u591a\u91cd\u6bd4\u5bf9\u7b97\u6cd5\u5305\u62ecClustalW\u3001MAFFT\u548cMUSCLE\u7b49\u3002<o:p><\/o:p><\/p>\n<p>\u603b\u4e4b\uff0c\u6210\u5bf9\u6bd4\u5bf9\u4e3b\u8981\u7528\u4e8e\u6d4b\u5e8f\u6570\u636e\u7684\u6bd4\u5bf9\uff0c\u5bf9\u4e8e\u53cc\u7aef\u6d4b\u5e8f\u6570\u636e\u80fd\u591f\u63d0\u4f9b\u66f4\u51c6\u786e\u7684\u91cd\u5efa\u548c\u7ed3\u6784\u6ce8\u91ca\u7ed3\u679c\u3002\u800c\u591a\u91cd\u6bd4\u5bf9\u5219\u9002\u7528\u4e8e\u591a\u4e2a\u76f8\u5173\u5e8f\u5217\u7684\u6bd4\u8f83\u5206\u6790\uff0c\u7528\u4e8e\u7814\u7a76\u5e8f\u5217\u4e4b\u95f4\u7684\u76f8\u4f3c\u6027\u3001\u53d8\u5f02\u6027\u548c\u8fdb\u5316\u5173\u7cfb\u7b49\u3002<\/p>\n<p><br \/><\/p>\n<h2><\/h2>\n<h2><strong><span style=\"color: rgb(2, 30, 170);\">\u5e8f\u5217\u6bd4\u5bf9\u6838\u5fc3\u95ee\u9898\uff1a<\/span><\/strong><\/h2>\n<p>\u5e8f\u5217\u6bd4\u5bf9\u7684\u6838\u5fc3\u95ee\u9898\u662f\u5bfb\u627e<strong>\u6700\u957f\u516c\u5171\u5b50\u5e8f\u5217\uff08LCS\uff0cLongest Common Subsequence\uff09<\/strong><o:p><\/o:p><\/p>\n<p>\u5f53\u53c2\u4e0e\u6bd4\u5bf9\u7684\u5e8f\u5217\u8db3\u591f\u957f\u7684\u65f6\u5019\uff0c\u6bd4\u5bf9\u60c5\u51b5\u4f1a\u53d8\u590d\u6742\uff0c\u4e00\u6761\u5e8f\u5217\u53ef\u80fd\u540c\u65f6\u6bd4\u5bf9\u4e0a\u591a\u4e2a\u4e0d\u540c\u7684\u533a\u57df\uff0c\u5982\u4f55\u627e\u5230\u6700\u4f73\u5339\u914d\u60c5\u51b5\uff1f\u4e3e\u4e2a\u4f8b\u5b50\uff1a\u5982\u6291\u764c\u57fa\u56e0p53, \u5168\u957f\u8d85\u8fc725kb\uff0c\u6bd4\u5bf9\u60c5\u51b5\u590d\u6742\uff0c\u5982\u4f55\u8fdb\u884c\u6bd4\u5bf9\u8bc4\u4ef7\uff1f<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"1.1142857142857143\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_oAEvaale5icbpO4UKzPc2qF7mmLVSw-9.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSaXyqPOufJLOwQysye68E2sRahoAEvaale5icbpO4UKzPc2qF7mmLVSw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"560\" style=\"\" \/><\/p>\n<p><br \/><\/p>\n<p><br \/><\/p>\n<p>\u6211\u4eec\u53ef\u4ee5\u901a\u8fc7\u5bfb\u627e\u6700\u957f\u516c\u5171\u5b50\u4e32\u6216\u6700\u957f\u516c\u5171\u5b50\u5e8f\u5217\u7684\u65b9\u6cd5\u6765\u89e3\u51b3\u4e0a\u8ff0\u95ee\u9898\u3002\u4e24\u6761\u5e8f\u5217\u7684\u6700\u957f\u516c\u5171\u5b50\u5e8f\u5217\uff0c\u5c31\u662f\u6307\u8fd9\u4e24\u6761\u5e8f\u5217\u5171\u6709\u7684\u5b50\u5e8f\u5217\uff0c\u4e14\u957f\u5ea6\u6700\u957f\u3002<o:p><\/o:p><\/p>\n<p>\u4ee5\u4e0b\u8ff0\u4e24\u6761\u5e8f\u5217\u4e3a\u4f8b\uff1a<o:p><\/o:p><\/p>\n<p>GACGGATTAG<o:p><\/o:p><\/p>\n<p>GATCGGAATAG<o:p><\/o:p><\/p>\n<p>\u8fd9\u4e24\u6761\u5e8f\u5217\u7684LCS\u662fCGGA\u3002\u5f53\u7136\uff0c\u6211\u4eec\u5f88\u5bb9\u6613\u627e\u5230\u5176\u4ed6\u957f\u5ea6\u8f83\u77ed\u7684\u5b50\u5e8f\u5217\uff0c\u5982CGG\uff0cTAG\uff0c\u4f46\u5176\u4e2d\u6700\u957f\u7684\u662fCGGA\u3002\u4e00\u822c\u60c5\u51b5\u4e0b\uff0c\u53c2\u4e0e\u6bd4\u5bf9\u7684\u5e8f\u5217\u8db3\u591f\u957f\u65f6\uff0c\u53ef\u80fd\u4f1a\u51fa\u73b0\u591a\u4e2aLCS\uff0c\u4f46\u6b64\u5904LCS\u552f\u4e00\uff0c\u957f\u5ea6\u4e3a4\u3002<o:p><\/o:p><\/p>\n<p>LCS\u975e\u5e38\u6709\u52a9\u4e8e\u8ba1\u7b97\u4e24\u4e2a\u5e8f\u5217\u7684\u76f8\u4f3c\u7a0b\u5ea6\uff1aLCS\u8d8a\u957f\uff0c\u5e8f\u5217\u76f8\u4f3c\u5ea6\u8d8a\u9ad8\u3002<o:p><\/o:p><\/p>\n<p><br \/><\/p>\n<h2><span style=\"color: rgb(2, 30, 170);\"><strong>\u8ba1\u5206\u77e9\u9635\uff1a<\/strong><\/span><o:p><\/o:p><\/h2>\n<p>\u5982\u4f55\u8bbe\u8ba1\u7b97\u6cd5\uff0c\u5feb\u901f\u3001\u7cbe\u51c6\u5730\u5b8c\u6210\u957f\u5e8f\u5217\u3001\u591a\u5e8f\u5217\u7b49\u590d\u6742\u6bd4\u5bf9\u8ba1\u7b97\uff1f<o:p><\/o:p><\/p>\n<p>\u6211\u4eec\u5c06\u88ab\u6bd4\u5bf9\u5e8f\u5217\u4e4b\u95f4\u53ef\u80fd\u7684\u4f4d\u70b9\u5173\u7cfb\u8fdb\u884c\u5f52\u7eb3\uff0c\u53ef\u4ee5\u5206\u4e3a\u4ee5\u4e0b3\u7c7b\uff1a<o:p><\/o:p><\/p>\n<p>1\uff09\u5339\u914d\uff08|\uff09<o:p><\/o:p><\/p>\n<p>2\uff09\u66ff\u6362\/\u9519\u914d\uff08*\uff09<o:p><\/o:p><\/p>\n<p>3\uff09\u7a7a\u4f4d\uff08\u63d2\u5165\/\u7f3a\u5931 -\uff09<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.125\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-14_\u300c\u8f6c\u300dDNA\u751f\u4fe1\u5206\u6790\uff08\u4e94\uff09\uff1a\u5927\u795e\u4e4b\u8def\uff01\u5341\u5206\u949f\u8be6\u89e3\u5e8f\u5217\u6bd4\u5bf9\u539f\u7406\/3_K3uiar7EyIJgA47rAWTa2UUWzfm4LQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSYXEqvcF6FDIMYoYCo7HiaeAjrvK3uiar7EyIJgA47rAWTa2UUWzfm4LQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"560\" style=\"\" \/><\/p>\n<p><br \/><\/p>\n<p>\u73b0\u5728\uff0c\u6211\u4eec\u5f15\u5165\u53e6\u5916\u4e00\u4e2a\u6982\u5ff5\uff0c<strong>\u76f8\u4f3c\u6027\u3002<\/strong><o:p><\/o:p><\/p>\n<p>\u76f8\u4f3c\u6027\u7684\u610f\u4e49\u4e0e\u4e00\u81f4\u6027\u7c7b\u4f3c\uff0c\u5176\u6570\u503c\u4e5f\u662f\u7528\u6765\u8861\u91cf\u5e8f\u5217\u7684\u76f8\u4f3c\u7a0b\u5ea6\u3002\u5728\u5bf9DNA\u5e8f\u5217\u8fdb\u884c\u6bd4\u5bf9\u65f6\uff0c\u6211\u4eec\u53ef\u4ee5\u91c7\u7528\u4ee5\u4e0b\u4e09\u79cd\u4e0d\u540c\u7684<strong>\u6838\u9178\u5e8f\u5217\u66ff\u6362\u77e9\u9635\uff08\u8ba1\u5206\u77e9\u9635\uff09<\/strong>\u5bf9\u5e8f\u5217\u7684\u76f8\u4f3c\u6027\u8fdb\u884c\u6253\u5206\uff1a<o:p><\/o:p><\/p>\n<p>1.\u7b49\u4ef7\u66ff\u6362\u77e9\u9635\uff1a\u76f8\u540c\u6838\u82f7\u9178\u4e4b\u95f4\u7684\u5339\u914d\u5f97\u5206\u4e3a1\uff0c\u4e0d\u540c\u6838\u82f7\u9178\u4e4b\u95f4\u7684\u66ff\u6362\u5f97\u5206\u4e3a0\u3002\u8fd9\u79cd\u6253\u5206\u65b9\u5f0f\u7684\u4f18\u70b9\u662f\u7b80\u5355\uff0c\u4f46\u7531\u4e8e\u6ca1\u6709\u8003\u8651\u5230\u5b9e\u9645\u7684\u7edf\u8ba1\u89c4\u5f8b\u6216\u751f\u7269\u6f14\u5316\u89c4\u5f8b\uff0c\u5b9e\u9645\u5e94\u7528\u8f83\u5c11<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.8981042654028436\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_8QZRtUO9Kvq5IFSibTVe1UY47Oj39w-9.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSBib0wPEubibjBpQqico7HAyqiaetP8QZRtUO9Kvq5IFSibTVe1UY47Oj39w\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"422\" style=\"width: 307px;height: 276px;\" \/><\/p>\n<p><span style=\"\"><o:p><\/o:p><\/span><\/p>\n<p><span style=\"\"><o:p><\/o:p><\/span><\/p>\n<section powered-by=\"xiumi.us\">\n<p>2.\u8f6c\u6362-\u98a0\u6362\u77e9\u9635\uff1aDNA\u5e8f\u5217\u75314\u79cd\u57fa\u672c\u7684\u8131\u6c27\u6838\u7cd6\u6838\u82f7\u9178\u5355\u5206\u5b50\u7ec4\u6210\uff0c\u6838\u82f7\u9178\u5206\u5b50\u7684\u6838\u5fc3\u7ed3\u6784\u5dee\u5f02\u662f4\u79cd\u542b\u6c2e\u78b1\u57fa\uff0c\u5206\u522b\u662f\u817a\u560c\u5464\uff08Adenine\uff0c\u7b80\u79f0A\uff09\uff0c\u9e1f\u560c\u5464\uff08Guanine\uff0c\u7b80\u79f0G\uff09\uff0c\u80f8\u817a\u5627\u5576\uff08Thymine\uff0c\u7b80\u79f0T\uff09\uff0c\u80de\u5627\u5576\uff08Cytosine\uff0c\u7b80\u79f0C\uff09\u3002\u5728\u6570\u636e\u5206\u6790\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4eec\u5f80\u5f80\u7528\u78b1\u57fa\u5e8f\u5217\u6307\u4ee3DNA\u5e8f\u5217\u3002<strong>\u5728\u751f\u7269\u6f14\u5316\u8fc7\u7a0b\u4e2d\uff0c4\u79cd\u78b1\u57fa\u53d1\u751f\u76f8\u4e92\u66ff\u6362\u7684\u6982\u7387\u5e76\u4e0d\u5747\u7b49\uff0c\u560c\u5464\u5bb9\u6613\u88ab\u560c\u5464\u66ff\u6362\uff08A\u2194\u5934G\uff09\uff0c\u5627\u5576\u5bb9\u6613\u88ab\u5627\u5576\u66ff\u6362\uff08C\u2194T\uff09\uff0c\u8fd9\u6837\u7684\u66ff\u6362\u88ab\u79f0\u4e3a\u8f6c\u6362\uff1b\u560c\u5464\u4e0e\u5627\u5576\u4e4b\u95f4\u53d1\u751f\u66ff\u6362\uff0c\u5219\u88ab\u79f0\u4e3a\u98a0\u6362\u3002\u8f6c\u6362\u6bd4\u98a0\u6362\u66f4\u5bb9\u6613\u53d1\u751f\uff0c\u4e3a\u4f53\u73b0\u8fd9\u6837\u7684\u6f14\u5316\u89c4\u5f8b\uff0c\u5728\u5bf9\u5e8f\u5217\u6bd4\u5bf9\u8fdb\u884c\u6253\u5206\u65f6\uff0c\u901a\u5e38\u5bf9\u8f6c\u6362\u8d4b\u5206\u4e3a-1\uff0c\u5bf9\u98a0\u6362\u8d4b\u5206\u4e3a-5.<span style=\"\"><o:p><\/o:p><\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.9405286343612335\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-14_\u300c\u8f6c\u300dDNA\u751f\u4fe1\u5206\u6790\uff08\u4e94\uff09\uff1a\u5927\u795e\u4e4b\u8def\uff01\u5341\u5206\u949f\u8be6\u89e3\u5e8f\u5217\u6bd4\u5bf9\u539f\u7406\/5_e7vbV0fMSVMia7tmQLu3MJ8t4OIKxA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSH9Bdh4niaDBJ3G4jU9jfqlVt4Oe7vbV0fMSVMia7tmQLu3MJ8t4OIKxA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"454\" style=\"width: 323px;height: 304px;\" \/><\/p>\n<p><br \/><\/p>\n<ol class=\"list-paddingleft-1\" style=\"list-style-type: decimal;\">\n<li>\n<p>BLAST\u77e9\u9635\uff1a\u5728\u5b9e\u9645\u4f7f\u7528\u8fc7\u7a0b\u4e2d\uff0c\u6839\u636e\u7edf\u8ba1\u7ecf\u9a8c\uff0c\u5c06\u78b1\u57fa\u5b8c\u5168\u76f8\u540c\u7684\u60c5\u51b5\u8d4b\u5206\u4e3a5\uff0c\u6bd4\u5bf9\u4e0d\u4e0a\u7684\u60c5\u51b5\u8d4b\u5206\u4e3a-4\uff0c\u8ba1\u5206\u77e9\u9635\u8ba1\u7b97\u6240\u5f97\u7ed3\u679c\u8f83\u597d\uff0c\u56e0\u6b64\u5c06\u6b64\u65b9\u6cd5\u5e7f\u6cdb\u5e94\u7528\u4e8eDNA\u5e8f\u5217\u6bd4\u5bf9\u3002<span style=\"\"><o:p><\/o:p><\/span><\/p>\n<p><br \/><\/p>\n<\/li>\n<\/ol>\n<p style=\"text-align: center;\"><br \/><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.9018789144050104\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_dd2cQY67XicmicP1TR7E5Ax4LV9Ksg-9.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZS5VAjQvJUEZunnnJX0eQQgrgrlRdd2cQY67XicmicP1TR7E5Ax4LV9Ksg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"479\" style=\"width: 311px;height: 280px;\" \/><\/p>\n<h2><\/h2>\n<h2><span style=\"color: rgb(2, 30, 170);\"><strong>\u52a8\u6001\u89c4\u5212\u7b97\u6cd5\uff1a<\/strong><\/span><o:p><\/o:p><\/h2>\n<p>\u6211\u4eec\u5047\u8bbe\u6709\u4e24\u4e2a\u957f\u5ea6\u5206\u522b\u4e3am\u548cn\u7684\u5e8f\u5217S\u2081\u548cS\u2082\uff0c\u5176\u4e2dS\u2081=a\u2081 a\u2082 … a(m)\uff0cS\u2082=b\u2081 b\u2082 … b(n)\u3002<o:p><\/o:p><\/p>\n<p>\u6211\u4eec\u5c06\u6784\u5efa\u4e00\u4e2a\u77e9\u9635A\uff0c\u5176\u4e2d<strong>A(i,j)\u8868\u793aa\u2081 a\u2082 … a(i)\u548cb\u2081 b\u2082 … b(j)\u7684\u6700\u957f\u5171\u540c\u5b50\u5e8f\u5217\u7684\u957f\u5ea6\u3002<\/strong><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.8517857142857143\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-14_\u300c\u8f6c\u300dDNA\u751f\u4fe1\u5206\u6790\uff08\u4e94\uff09\uff1a\u5927\u795e\u4e4b\u8def\uff01\u5341\u5206\u949f\u8be6\u89e3\u5e8f\u5217\u6bd4\u5bf9\u539f\u7406\/7_Pa9WEUuhypVImkQec0uZr0IH9WK8wQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSk0Ysf3WNVd2s5qEGPtjL6qh2Pa9WEUuhypVImkQec0uZr0IH9WK8wQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"560\" style=\"width: 298px;height: 254px;\" \/><\/p>\n<p><br \/><\/p>\n<p>\u5e8f\u5217S\u2081\u662f\u7ad6\u7740\u5199\u7684\uff0cS\u2082\u662f\u6a2a\u7740\u5199\u7684\u3002\u9010\u884c\u3001\u9010\u5217\u5730\u5c06\u4ee3\u8868\u884c\u7684\u6bcf\u4e2a\u5b57\u6bcd\u4e0e\u4ee3\u8868\u5217\u7684\u6bcf\u4e2a\u5b57\u6bcd\u8fdb\u884c\u6bd4\u8f83\u3002<o:p><\/o:p><\/p>\n<p>1. \u5982\u679ca(i) = b(j)\uff0c\u90a3\u4e48\u6211\u4eec\u5c31\u627e\u5230\u4e86\u4e00\u4e2a\u5339\u914d\uff08match\uff09\u3002\u6211\u4eec\u4e3a\u5f53\u524d\u7684\u5339\u914d\u8d4b\u503c1\u5206\uff1b<o:p><\/o:p><\/p>\n<p>2. \u5982\u679ca(i)\u2260b(j)\uff0c\u90a3\u4e48\u6211\u4eec\u5c31\u6709\u4e00\u4e2a\u4e0d\u5339\u914d\uff08mismatch\uff09\u3002<o:p><\/o:p><\/p>\n<p>\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6211\u4eec\u9700\u8981\u8003\u8651\u4e24\u79cd\u53ef\u80fd\u6027\uff1a\u7531 a\u2081 … a(i)\u548cb\u2081 … b(j-1) \u5f97\u5230\u7684LCS\uff0c\u4ee5\u53ca\u7531a\u2081 … a(i-1)\u548cb\u2081 … b(j)\u7684LCS\u3002<o:p><\/o:p><\/p>\n<p>\u53ef\u7531\u4ee5\u4e0b\u516c\u5f0f\u8868\u793a\uff1a<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.19464285714285715\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_AicpticxxIhXd5cIlzWPYM8uwbXBug-9.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSS8CHkyeVTiaUDZGcZDeEFMm5PN5AicpticxxIhXd5cIlzWPYM8uwbXBug\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"560\" style=\"\" \/><\/p>\n<p><br \/><\/p>\n<p>\u5047\u5982\u5c0f\u4f19\u4f34\u4eec\u8fd8\u662f\u4e0d\u592a\u7406\u89e3\u52a8\u6001\u89c4\u5212\u7b97\u6cd5\uff0c\u5c0f\u82b1\u5728\u8fd9\u91cc\u4e3e\u4e2a\u4f8b\u5b50\uff1a<o:p><\/o:p><\/p>\n<p>\u201c\u5728\u7eb8\u4e0a\u5199\u4e0b’1+1+1+1+1+1+1+1 =’\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u8fd9\u4e2a\u7b49\u4e8e\u591a\u5c11\uff1f\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u662f\u516b\uff01\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u5728\u5f0f\u5b50\u5de6\u8fb9\u518d\u5199\u4e00\u4e2a’1+’\u5462\uff1f\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u662f\u4e5d\uff01\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u4f60\u600e\u4e48\u80fd\u8fd9\u4e48\u5feb\u77e5\u9053\u662f\u4e5d\u7684\uff1f\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u56e0\u4e3a\u6211\u53ea\u9700\u8981\u8ba9\u516b\u518d\u52a0\u4e00\u3002\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u6240\u4ee5\u4f60\u4e0d\u9700\u8981\u4ece\u5934\u5f00\u59cb\u91cd\u65b0\u6570\u6570\uff0c\u56e0\u4e3a\u4f60\u8bb0\u5f97\u539f\u6765\u662f\u516b\uff01\u52a8\u6001\u89c4\u5212\u5176\u5b9e\u5c31\u662f\u4e00\u79cd\u82b1\u54e8\u7684\u8bf4\u6cd5\uff0c\u5b83\u7684\u610f\u601d\u662f\u2018\u8bb0\u4f4f\u73b0\u5728\u4e3a\u4ee5\u540e\u7701\u65f6\u95f4\u2019\u3002\u201d<o:p><\/o:p><\/p>\n<p>\u770b\u5230\u8fd9\u91cc\uff0c\u5c0f\u82b1\u76f8\u4fe1\u5c0f\u4f19\u4f34\u4eec\u5df2\u7ecf\u7406\u89e3\u4e86\u52a8\u6001\u89c4\u5212\u7b97\u6cd5\u7684\u6838\u5fc3\u601d\u60f3\u5566\uff0c\u90a3\u4e48\u52a8\u6001\u89c4\u5212\u7b97\u6cd5\u5982\u4f55\u5e94\u7528\u5728\u5e8f\u5217\u6bd4\u5bf9\u4e2d\u5462\uff1f\u4e0d\u8981\u7740\u6025\uff0c\u6211\u4eec\u63a5\u7740\u5f80\u4e0b\u770b\uff1a<o:p><\/o:p><\/p>\n<p><br \/><\/p>\n<h2><\/h2>\n<h2><span style=\"color: rgb(2, 30, 170);\"><strong>Smith-Waterman\u7b97\u6cd5\u548cNeedleman-Wunsch\u7b97\u6cd5<\/strong><\/span><o:p><\/o:p><\/h2>\n<p>\u52a8\u6001\u89c4\u5212\u7b97\u6cd5\u5728\u5e8f\u5217\u6bd4\u5bf9\u4e2d\u6700\u8457\u540d\u7684\u5c31\u662fSmith-Waterman\u7b97\u6cd5\u548cNeedleman-Wunsch\u7b97\u6cd5\uff0c\u8fd9\u4e24\u79cd\u7b97\u6cd5\u90fd\u662f\u57fa\u4e8e\u52a8\u6001\u89c4\u5212\u7684\u601d\u60f3\uff0c\u7528\u4e8e\u5bfb\u627e\u4e24\u4e2a\u5e8f\u5217\u4e4b\u95f4\u7684\u6700\u4f73\u6bd4\u5bf9\u65b9\u6848\u3002<o:p><\/o:p><\/p>\n<p>Smith-Waterman\u7b97\u6cd5<strong>\u53ef\u4ee5\u627e\u5230\u4e24\u4e2a\u5e8f\u5217\u4e4b\u95f4\u7684\u6700\u4f73\u5c40\u90e8\u6bd4\u5bf9\u65b9\u6848\uff0c\u5373\u5728\u54ea\u4e2a\u4f4d\u7f6e\u5f00\u59cb\uff0c\u4ee5\u53ca\u4ece\u54ea\u4e2a\u4f4d\u7f6e\u7ed3\u675f\u3002<\/strong>\u4ee5\u4e0b\u662f\u7b97\u6cd5\u7684\u5177\u4f53\u6b65\u9aa4\uff1a<o:p><\/o:p><\/p>\n<p>\u2022\u6784\u5efa\u5f97\u5206\u77e9\u9635\uff1a\u6839\u636e\u7ed9\u5b9a\u7684\u5f97\u5206\u89c4\u5219\uff08\u5982\u66ff\u6362\u5f97\u5206\u3001\u7f3a\u5931\/\u63d2\u5165\u5f97\u5206\u7b49\uff09\uff0c\u6784\u5efa\u4e00\u4e2a\u5927\u5c0f\u4e3a(n+1) x (m+1)\u7684\u5f97\u5206\u77e9\u9635\uff0c\u5176\u4e2dn\u548cm\u5206\u522b\u4e3a\u4e24\u4e2a\u5e8f\u5217\u7684\u957f\u5ea6\u3002\u521d\u59cb\u5316\u5f97\u5206\u77e9\u9635\u7684\u6240\u6709\u5143\u7d20\u4e3a\u96f6\u3002<o:p><\/o:p><\/p>\n<p>\u2022\u521d\u59cb\u5316\uff1a\u5c06\u5f97\u5206\u77e9\u9635\u7684\u7b2c\u4e00\u884c\u548c\u7b2c\u4e00\u5217\u90fd\u521d\u59cb\u5316\u4e3a\u96f6\u3002\u540c\u65f6\u8bb0\u5f55\u6700\u5927\u5f97\u5206\u53ca\u5176\u6240\u5728\u7684\u4f4d\u7f6e\u3002<o:p><\/o:p><\/p>\n<p>\u2022\u586b\u5145\u5f97\u5206\u77e9\u9635\uff1a\u4ece\u5f97\u5206\u77e9\u9635\u7684\u7b2c\u4e8c\u884c\u548c\u7b2c\u4e8c\u5217\u5f00\u59cb\uff0c\u6309\u7167\u4ee5\u4e0b\u89c4\u5219\u8ba1\u7b97\u6bcf\u4e2a\u683c\u5b50\u7684\u5f97\u5206\uff1a<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u4e24\u4e2a\u5b57\u7b26\u5339\u914d\uff0c\u5c06\u5de6\u4e0a\u65b9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u5f53\u524d\u5b57\u7b26\u7684\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u4e24\u4e2a\u5b57\u7b26\u4e0d\u5339\u914d\uff0c\u5c06\u5de6\u4e0a\u65b9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u66ff\u6362\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u5b57\u7b26\u6765\u81ea\u7f3a\u5931\u5e8f\u5217\uff0c\u5c06\u5de6\u8fb9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u7f3a\u5931\/\u63d2\u5165\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u5b57\u7b26\u6765\u81ea\u63d2\u5165\u5e8f\u5217\uff0c\u5c06\u4e0a\u65b9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u7f3a\u5931\/\u63d2\u5165\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2022\u56de\u6eaf\uff1a\u4ece\u6700\u5927\u5f97\u5206\u53ca\u5176\u4f4d\u7f6e\u5f00\u59cb\uff0c\u6309\u7167\u5f97\u5206\u77e9\u9635\u4e2d\u7684\u5f97\u5206\u89c4\u5219\uff0c\u56de\u6eaf\u627e\u5230\u6700\u4f73\u7684\u6bd4\u5bf9\u8def\u5f84\uff0c\u5e76\u751f\u6210\u6700\u4f73\u6bd4\u5bf9\u5e8f\u5217\u3002<o:p><\/o:p><\/p>\n<p>Needleman-Wunsch\u7b97\u6cd5<strong>\u53ef\u4ee5\u627e\u5230\u4e24\u4e2a\u5e8f\u5217\u4e4b\u95f4\u7684\u6700\u4f73\u5168\u5c40\u6bd4\u5bf9\u65b9\u6848\uff0c\u5373\u4ece\u5e8f\u5217\u7684\u8d77\u59cb\u4f4d\u7f6e\u5230\u7ed3\u675f\u4f4d\u7f6e\u7684\u6700\u4f73\u6bd4\u5bf9\u65b9\u6848\u3002<\/strong>\u4ee5\u4e0b\u662f\u7b97\u6cd5\u7684\u5177\u4f53\u6b65\u9aa4\uff1a<o:p><\/o:p><\/p>\n<p>\u2022\u6784\u5efa\u5f97\u5206\u77e9\u9635\uff1a\u540c\u6837\u6839\u636e\u7ed9\u5b9a\u7684\u5f97\u5206\u89c4\u5219\uff0c\u6784\u5efa\u4e00\u4e2a\u5927\u5c0f\u4e3a(n+1) x (m+1)\u7684\u5f97\u5206\u77e9\u9635\uff0c\u5176\u4e2dn\u548cm\u5206\u522b\u4e3a\u4e24\u4e2a\u5e8f\u5217\u7684\u957f\u5ea6\u3002\u521d\u59cb\u5316\u5f97\u5206\u77e9\u9635\u7684\u7b2c\u4e00\u884c\u548c\u7b2c\u4e00\u5217\uff0c\u5373\u8003\u8651\u7f3a\u5931\/\u63d2\u5165\u7684\u60c5\u51b5\u3002<o:p><\/o:p><\/p>\n<p>\u2022\u586b\u5145\u5f97\u5206\u77e9\u9635\uff1a\u4ece\u5f97\u5206\u77e9\u9635\u7684\u7b2c\u4e8c\u884c\u548c\u7b2c\u4e8c\u5217\u5f00\u59cb\uff0c\u6309\u7167\u4ee5\u4e0b\u89c4\u5219\u8ba1\u7b97\u6bcf\u4e2a\u683c\u5b50\u7684\u5f97\u5206\uff1a<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u4e24\u4e2a\u5b57\u7b26\u5339\u914d\uff0c\u5c06\u5de6\u4e0a\u65b9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u5f53\u524d\u5b57\u7b26\u7684\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u4e24\u4e2a\u5b57\u7b26\u4e0d\u5339\u914d\uff0c\u5c06\u5de6\u4e0a\u65b9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u66ff\u6362\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u5b57\u7b26\u6765\u81ea\u7f3a\u5931\u5e8f\u5217\uff0c\u5c06\u5de6\u8fb9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u7f3a\u5931\/\u63d2\u5165\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u5b57\u7b26\u6765\u81ea\u63d2\u5165\u5e8f\u5217\uff0c\u5c06\u4e0a\u65b9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u7f3a\u5931\/\u63d2\u5165\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2022\u56de\u6eaf\uff1a\u4ece\u5f97\u5206\u77e9\u9635\u7684\u6700\u540e\u4e00\u4e2a\u683c\u5b50\u5f00\u59cb\uff0c\u6309\u7167\u5f97\u5206\u77e9\u9635\u4e2d\u7684\u5f97\u5206\u89c4\u5219\uff0c\u56de\u6eaf\u627e\u5230\u6700\u4f73\u7684\u6bd4\u5bf9\u8def\u5f84\uff0c\u5e76\u751f\u6210\u6700\u4f73\u6bd4\u5bf9\u5e8f\u5217\u3002<\/p>\n<p><span style=\"\"><o:p><\/o:p><\/span><\/p>\n<p style=\"text-align: justify;\"><br \/><\/p>\n<\/section>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 98%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;height: auto;border-style: solid;border-width: 2px;border-color: rgb(160, 160, 160);padding: 27px;\">\n<section style=\"text-align: justify;line-height: 1.6;letter-spacing: 0px;padding-right: 6px;padding-left: 6px;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<p><br \/><\/p>\n<p><span style=\"font-family: Cambria;font-size: 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solid #e1e1e1;margin-top:10px;}.msgBodyReplyListTop{border-top:0;}.reply_like_num{float:right;font-size:14px;color:#c7c7c7;}.msgData{margin-top:20px;color:#626262;}.msgData span{font-size:14px;padding-right:15px;}.msgData .likes{float:right;padding-right:0;}.js_text_content p{font-size:18px;}.rich_media_meta_link{font-size:15px;}blockquote {padding-left: 10px;border-left: 3px solid #dbdbdb;color: rgba(0,0,0,0.5);font-size: 15px;padding-top: 4px;margin: 1em 0;}.video_iframe{width:500px;height:400px;}.blockquote_info{color:#b5b5b5;margin-top:10px;}#copyright_logo{color:#bdbdbd;}.rich_media_meta_list{margin-bottom:10px;}.reprint{background:#efefef;border-radius:5px;padding:8px;color:#1f1f1f;}.reprint a{word-break:break-all;}.topic{color:#8e8e8e;background:#f7f7f7;border-radius:5px;padding:10px 8px;}.topic a{padding-right:5px;}.topic p{margin-bottom:5px;}\n<\/style>\n<link href=\"https:\/\/www.juyifx.cn\/config\/css\/wxArticle.css\" rel=\"stylesheet\"\/>\n<\/head><script>\nvar data={\"mp\":\"\u751f\u4fe1\u679c\",\"title\":\"DNA\u751f\u4fe1\u5206\u6790\uff08\u4e94\uff09\uff1a\u5927\u795e\u4e4b\u8def\uff01\u5341\u5206\u949f\u8be6\u89e3\u5e8f\u5217\u6bd4\u5bf9\u539f\u7406\",\"time\":\"2023-09-14 19:00:49\",\"timeStamp\":\"1694689249\"};\n<\/script><br \/>\n<body><\/p>\n<div class=\"rich_media\">\n<h1 class=\"rich_media_title\" id=\"activity-name\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247492977&idx=3&sn=92b9823ca997d1b7267a5da689ba5628&chksm=cf7f75b4f808fca2373b4ac792fea204b14b4b464999243bf604b7e424fefe38c81a8033a312#rd\" target=\"_blank\" rel=\"noopener\">DNA\u751f\u4fe1\u5206\u6790\uff08\u4e94\uff09\uff1a\u5927\u795e\u4e4b\u8def\uff01\u5341\u5206\u949f\u8be6\u89e3\u5e8f\u5217\u6bd4\u5bf9\u539f\u7406<\/a><\/h1>\n<div id=\"meta_content\" class=\"rich_media_meta_list\"><span class=\"rich_media_meta rich_media_meta_text\">\u5c0f\u82b1 <\/span><span class=\"rich_media_meta rich_media_meta_nickname\" id=\"profileBt\"><a href=\"javascript:void(0);\" class=\"wx_tap_link js_wx_tap_highlight weui-wa-hotarea\" id=\"js_name\">\u751f\u4fe1\u679c <\/a><\/span><em id=\"publish_time\" class=\"rich_media_meta rich_media_meta_text\">2023-09-14 19:00:49<\/em><\/div>\n<p><content><\/p>\n<div class=\"reprint\">\n<p>\u8f6c\u81ea\u516c\u4f17\u53f7\uff1a\u751f\u4fe1\u82b1<br \/><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkzODUxNjcwMA==&mid=2247484648&idx=1&sn=1db3a14b79bb2272be5271b60dfcad8b\" target=\"_blank\" title=\"\u9605\u8bfb\u539f\u6587\" rel=\"noopener\">http:\/\/mp.weixin.qq.com\/s?__biz=MzkzODUxNjcwMA==&mid=2247484648&idx=1&sn=1db3a14b79bb2272be5271b60dfcad8b<\/a><\/p>\n<\/div>\n<section style=\"font-size: 14px;margin-bottom: 24px;\" data-mpa-powered-by=\"yiban.io\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: rgb(65, 128, 216);\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 5%;flex: 0 0 auto;height: auto;align-self: center;padding-left: 12px;\">\n<section style=\"text-align: justify;color: rgb(255, 255, 255);\" powered-by=\"xiumi.us\">\n<p><span style=\"color: rgb(120, 172, 254);\"><strong>\u70b9\u51fb\u84dd\u5b57 \u5173\u6ce8\u6211\u4eec<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 5%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: 34px;align-self: flex-start;flex: 0 0 auto;height: auto;overflow: hidden;margin-right: -17px;\">\n<section style=\"transform: rotateZ(60deg);\" powered-by=\"xiumi.us\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;\">\n<section style=\"width: 100%;height: 5px;background-color: rgb(255, 255, 255);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 34px;align-self: flex-start;flex: 0 0 auto;height: auto;overflow: hidden;margin-right: -17px;\">\n<section style=\"transform: rotateZ(60deg);\" powered-by=\"xiumi.us\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;\">\n<section style=\"width: 100%;height: 5px;background-color: rgb(201, 229, 70);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 34px;align-self: flex-start;flex: 0 0 auto;height: auto;overflow: hidden;\">\n<section style=\"transform: rotateZ(60deg);\" powered-by=\"xiumi.us\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;\">\n<section style=\"width: 100%;height: 5px;background-color: rgb(255, 255, 255);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<h1><\/h1>\n<h1><\/h1>\n<h1><\/h1>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<h1><strong><span style=\"color: rgb(2, 30, 170);\">\u5341\u5206\u949f\u8be6\u89e3\u5e8f\u5217\u6bd4\u5bf9\u539f\u7406<\/span><\/strong><o:p><\/o:p><\/h1>\n<p>\u4e0a\u4e00\u6b21\u5c0f\u82b1\u7ed9\u5927\u5bb6\u4ed4\u7ec6\u5206\u4eab\u4e86\u5e8f\u5217\u6bd4\u5bf9\u7684\u8be6\u7ec6\u8fc7\u7a0b\u5e76\u4e14\u6bcf\u4e00\u6b65\u90fd\u505a\u4e86\u5145\u5206\u7684\u8bf4\u660e\uff0c\u60f3\u5fc5\u5c0f\u4f19\u4f34\u4eec\u90fd\u662f\u6536\u83b7\u6ee1\u6ee1\uff0c\u8feb\u4e0d\u53ca\u5f85\u5730\u60f3\u5b66\u4e60\u5e8f\u5217\u6bd4\u5bf9\u7684\u539f\u7406\u4e86\u5427\uff01\u8fd9\u4e00\u6b21\u5c0f\u82b1\u5c31\u6765\u5206\u4eab\u5e8f\u5217\u6bd4\u5bf9\u7684\u539f\u7406\uff0c\u5e72\u8d27\u6ee1\u6ee1\u7684\u540c\u65f6\u53ef\u80fd\u4f1a\u7a0d\u5fae\u6709\u4e00\u70b9\u96be\u5ea6\uff0c\u4f46\u662f\u60f3\u8981\u6210\u4e3a\u751f\u4fe1\u5927\u795e\uff0c\u5c0f\u4f19\u4f34\u4eec\u5c31\u4e0d\u80fd\u4e0d\u4e86\u89e3\u8be6\u7ec6\u7684\u539f\u7406\u54e6~\u5e9f\u8bdd\u4e0d\u591a\u8bf4\uff0c\u6211\u4eec\u76f4\u63a5\u5f00\u59cb\u5427\uff01<o:p><\/o:p><\/p>\n<h2><br \/><\/h2>\n<h2><strong><span style=\"color: rgb(2, 30, 170);\">\u5e8f\u5217\u6bd4\u5bf9\u95ee\u9898\u6a21\u578b\uff1a<\/span><\/strong><o:p><\/o:p><\/h2>\n<p>\u6765\u81ea\u4e0d\u540c\u751f\u7269\u4f53\u7684\u5e8f\u5217\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u5dee\u5f02\uff0c\u8981\u628a\u5b83\u4eec\u6392\u5217\u5bf9\u9f50\u5c31\u9700\u8981\u5728\u5e8f\u5217\u6bd4\u5bf9\u4e0d\u9f50\u7684\u4f4d\u7f6e\u63d2\u5165\u201c\u7a7a\u683c\u201d\u6216\u201c\u95f4\u9699\u201d\uff0c\u4ee5\u4f7f\u5176\u5177\u6709\u76f8\u540c\u7684\u957f\u5ea6\u3002<o:p><\/o:p><\/p>\n<p>\u4e3e\u4e2a\u4f8b\u5b50\uff0c\u5047\u8bbe\u6709\u4ee5\u4e0b\u4e24\u4e2aDNA\u5e8f\u5217GACGGATTAG\u548cGATCGGAATAG\u3002\u8fd9\u4e24\u4e2a\u5e8f\u5217\u4e4b\u95f4\u4e00\u4e2a\u53ef\u80fd\u7684\u6392\u5217\u5982\u4e0b\uff1a<o:p><\/o:p><\/p>\n<h1><\/h1>\n<p><o:p><\/o:p><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.7520661157024794\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_at554nlnGhTOs4jkFLFhvgY5IXEhbQ-9.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSLagtksYRLUn1j2c9AKmIvpuGiat554nlnGhTOs4jkFLFhvgY5IXEhbQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"242\" style=\"\" \/><\/p>\n<p style=\"text-align: center;\"><br \/><\/p>\n<\/section>\n<p>\u5728\u8fd9\u79cd\u5bf9\u9f50\u65b9\u5f0f\u4e0b\uff0c\u7b2c\u4e00\u6761\u5e8f\u5217\u4e0a\u6709\u4e00\u4e2a\u78b1\u57faT\u5728\u7b2c\u4e8c\u6761\u5e8f\u5217\u4e0a\u53d8\u6210\u4e86\u78b1\u57faA\uff1b\u7b2c\u4e8c\u6761\u5e8f\u5217\u4e2d\u591a\u4e86\u4e00\u4e2aT\uff0c\u901a\u8fc7\u5728\u7b2c\u4e00\u6761\u5e8f\u5217\u4e2d\u6dfb\u52a0\u4e00\u4e2a\u201c\u7a7a\u683c\u201d\uff0c\u4f7f\u4e24\u6761\u5e8f\u5217\u91cd\u65b0\u5bf9\u9f50\u3002<br \/><\/p>\n<p>\u5982\u4f55\u8bc4\u4ef7\u5e8f\u5217\u6bd4\u5bf9\u7ed3\u679c\uff1f\u6362\u53e5\u8bdd\u8bb2\uff0c\u5982\u4f55\u91cf\u5316\u4e24\u6761\u88ab\u6bd4\u8f83\u5e8f\u5217\u7684\u76f8\u4f3c\u7a0b\u5ea6\uff1f\u8fd9\u91cc\u5f15\u5165\u4e00\u4e2a\u6982\u5ff5<strong>\uff1a\u5e8f\u5217\u4e00\u81f4\u6027<\/strong>\uff0c\u5176\u6570\u503c\u4ee3\u8868\u8fdb\u884c\u5e8f\u5217\u6bd4\u5bf9\u65f6\uff0c\u6240\u9009\u5e8f\u5217\u5f53\u4e2d\uff0c<strong>\u76f8\u540c\u4f4d\u70b9\u7684\u78b1\u57fa\u5b8c\u5168\u4e00\u81f4\u7684\u6570\u91cf\u5360\u603b\u78b1\u57fa\u6570\u7684\u6bd4\u4f8b<\/strong>\u3002\u5e8f\u5217\u4e00\u81f4\u6027\u6700\u9ad8100%\uff0c\u6b64\u65f6\u8868\u793a\u5e8f\u5217\u5b8c\u5168\u4e00\u81f4\u3002\u5728\u4e0a\u9762\u7684\u4f8b\u5b50\u5f53\u4e2d\uff0c\u4e24\u6761\u5e8f\u5217\u7684\u4e00\u81f4\u6027\u4e3a9\/11*100%=81.82%\uff08\u7b97\u4e0a\u8865\u9f50\u7684-\u6bcf\u6761\u5e8f\u521711\u4e2a\u78b1\u57fa\uff0c\u4ece\u5de6\u5f80\u53f3\u7684\u7b2c\u4e09\u4e2a\u548c\u7b2c\u516b\u4e2a\u78b1\u57fa\u5bf9\u9f50\u5931\u8d25\uff0c\u5171\u4e5d\u4e2a\u5bf9\u9f50\u6210\u529f\uff09\u3002<o:p><\/o:p><\/p>\n<p><strong>\u5e8f\u5217\u6bd4\u5bf9\u7684\u5e38\u89c1\u7c7b\u578b<\/strong>\uff1a<o:p><\/o:p><\/p>\n<p>\u6839\u636e<strong>\u6bd4\u5bf9\u8303\u56f4<\/strong>\u4e0d\u540c\uff0c\u6709\u4e24\u79cd\u7c7b\u578b\u7684\u5bf9\u9f50\u65b9\u5f0f\uff1a<o:p><\/o:p><\/p>\n<p>1. <strong>\u5168\u5c40\u6bd4\u5bf9<\/strong>\uff1a\u5168\u5c40\u6bd4\u5bf9\u662f<strong>\u5c06\u6574\u4e2a\u67e5\u8be2\u5e8f\u5217\u4e0e\u53c2\u8003\u5e8f\u5217\u8fdb\u884c\u6bd4\u5bf9\uff0c\u76ee\u6807\u662f\u627e\u5230\u4e24\u4e2a\u5e8f\u5217\u4e4b\u95f4\u7684\u6700\u4f18\u5339\u914d<\/strong>\u3002\u5168\u5c40\u6bd4\u5bf9\u9002\u7528\u4e8e\u5177\u6709\u76f8\u5bf9\u8f83\u9ad8\u7684\u76f8\u4f3c\u6027\u4e14\u8f83\u957f\u7684\u5e8f\u5217\uff0c\u4f8b\u5982\u6bd4\u5bf9\u6574\u4e2a\u57fa\u56e0\u7ec4\u6216\u5168\u957f cDNA \u5e8f\u5217\u3002\u5e38\u7528\u7684\u5168\u5c40\u6bd4\u5bf9\u7b97\u6cd5\u5305\u62ec Needleman-Wunsch \u7b97\u6cd5\u548c Smith-Waterman \u7b97\u6cd5\u3002\u5168\u5c40\u6bd4\u5bf9\u4f1a\u8003\u8651\u6574\u4e2a\u5e8f\u5217\u7684\u5339\u914d\u3001\u66ff\u4ee3\u548c\u63d2\u5165\/\u5220\u9664\u4fe1\u606f\uff0c\u56e0\u6b64\u80fd\u591f\u53d1\u73b0\u8f83\u8fdc\u7684\u4eb2\u7f18\u5173\u7cfb\u548c\u6f14\u5316\u4fe1\u606f\uff0c\u4f46\u8ba1\u7b97\u6210\u672c\u8f83\u9ad8\u3002<o:p><\/o:p><\/p>\n<p>2<strong>. \u5c40\u90e8\u6bd4\u5bf9<\/strong>\uff1a\u5c40\u90e8\u6bd4\u5bf9\u662f<strong>\u5bfb\u627e\u4e24\u4e2a\u5e8f\u5217\u4e2d\u7684\u4e00\u4e2a\u6216\u591a\u4e2a\u7247\u6bb5\u7684\u6700\u4f18\u5339\u914d<\/strong>\u3002\u5c40\u90e8\u6bd4\u5bf9\u9002\u7528\u4e8e\u5177\u6709\u8f83\u5c0f\u7684\u7247\u6bb5\u6216\u5b58\u5728\u63d2\u5165\/\u5220\u9664\u7684\u60c5\u51b5\uff0c\u4f8b\u5982\u6bd4\u5bf9\u5df2\u77e5\u86cb\u767d\u8d28\u7ed3\u6784\u4e2d\u7684\u5c0f\u7247\u6bb5\u6216\u627e\u5230\u57fa\u56e0\u7ec4\u4e2d\u7684\u91cd\u590d\u5e8f\u5217\u3002\u5e38\u7528\u7684\u5c40\u90e8\u6bd4\u5bf9\u7b97\u6cd5\u662f Smith-Waterman \u7b97\u6cd5\u3002\u5c40\u90e8\u6bd4\u5bf9\u5c06\u91cd\u70b9\u653e\u5728\u6700\u4f73\u5339\u914d\u7247\u6bb5\u4e0a\uff0c\u56e0\u6b64\u53ef\u4ee5\u68c0\u6d4b\u5230\u66f4\u5c0f\u7684\u4eb2\u7f18\u5173\u7cfb\u548c\u6f14\u5316\u4fe1\u606f\uff0c\u4f46\u8ba1\u7b97\u6210\u672c\u4e5f\u4e0d\u4f4e\u3002<o:p><\/o:p><\/p>\n<p>\u4e00\u822c\u6765\u8bf4\uff0c\u5168\u5c40\u6bd4\u5bf9\u9002\u7528\u4e8e\u8f83\u957f\u7684\u5e8f\u5217\u4e14\u76f8\u4f3c\u6027\u8f83\u9ad8\u7684\u6bd4\u5bf9\uff0c\u80fd\u591f\u63d0\u4f9b\u66f4\u5168\u9762\u7684\u4fe1\u606f\uff0c\u4f46\u8ba1\u7b97\u6210\u672c\u8f83\u9ad8\u3002\u800c\u5c40\u90e8\u6bd4\u5bf9\u9002\u7528\u4e8e\u8f83\u77ed\u7247\u6bb5\u6216\u5b58\u5728\u53d8\u5f02\u7684\u6bd4\u5bf9\uff0c\u53ef\u4ee5\u66f4\u51c6\u786e\u5730\u627e\u5230\u6700\u4f73\u5339\u914d\uff0c\u4f46\u53ef\u80fd\u4f1a\u9519\u8fc7\u5168\u5c40\u7684\u6f14\u5316\u4fe1\u606f\u3002\u76f8\u5bf9\u4e8e\u5168\u5c40\u6bd4\u5bf9\u548c\u5c40\u90e8\u6bd4\u5bf9\uff0cSeed-and-Extend\uff08\u79cd\u5b50\u6269\u5c55\uff09\u6bd4\u5bf9\u65b9\u6cd5\u53ef\u4ee5\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u964d\u4f4e\u8ba1\u7b97\u6210\u672c\uff0c\u5b83\u7684\u57fa\u672c\u539f\u7406\u662f\u9996\u5148\u901a\u8fc7\u5feb\u901f\u7684\u79cd\u5b50\u5339\u914d\u8fc7\u7a0b\u627e\u5230\u4e00\u7ec4\u53ef\u80fd\u7684\u5339\u914d\u4f4d\u7f6e\uff0c\u7136\u540e\u5728\u8fd9\u4e9b\u4f4d\u7f6e\u5468\u56f4\u8fdb\u884c\u6269\u5c55\u4ee5\u5bfb\u627e\u6700\u4f73\u5339\u914d\u3002\u9650\u4e8e\u7bc7\u5e45\u5c0f\u82b1\u5728\u8fd9\u91cc\u5c31\u4e0d\u5c55\u5f00\u8bb2\u89e3\u4e86\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u4eec\u53ef\u4ee5\u81ea\u884c\u4e86\u89e3\u54e6~<o:p><\/o:p><\/p>\n<p>\u800c\u6839\u636e\u53c2\u4e0e<strong>\u6bd4\u5bf9\u5e8f\u5217\u7684\u6570\u91cf<\/strong>\uff0c\u4e5f\u6709\u4e24\u79cd\u4e0d\u540c\u7684\u6bd4\u5bf9\u65b9\u5f0f\uff1a<o:p><\/o:p><\/p>\n<p>1. <strong>\u6210\u5bf9\u6bd4\u5bf9<\/strong>\uff1a\u6210\u5bf9\u6bd4\u5bf9\u662f\u6307<strong>\u5c06\u6210\u5bf9\u7684\u6d4b\u5e8f\u8bfb\u6bb5\u540c\u65f6\u4e0e\u53c2\u8003\u5e8f\u5217\u8fdb\u884c\u6bd4\u5bf9<\/strong>\u3002\u5728\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u4e2d\uff0c\u901a\u5e38\u4f1a\u5bf9DNA\u6216RNA\u6837\u672c\u8fdb\u884c\u53cc\u7aef\u6d4b\u5e8f\uff0c\u751f\u6210\u4e24\u4e2a\u76f8\u4e92\u5bf9\u5e94\u7684\u6d4b\u5e8f\u8bfb\u6bb5\uff08Paired-End Reads\uff09\u3002\u6210\u5bf9\u6bd4\u5bf9\u7684\u76ee\u7684\u662f\u5c06\u8fd9\u4e24\u4e2a\u6d4b\u5e8f\u8bfb\u6bb5\u540c\u65f6\u5bf9\u9f50\u5230\u53c2\u8003\u5e8f\u5217\u4e0a\uff0c\u4ee5\u5bfb\u627e\u6700\u4f73\u5339\u914d\u4f4d\u7f6e\u3002<strong>\u6210\u5bf9\u6bd4\u5bf9\u80fd\u591f\u63d0\u4f9b\u66f4\u51c6\u786e\u7684\u6bd4\u5bf9\u7ed3\u679c<\/strong>\uff0c\u53ef\u4ee5\u5e2e\u52a9\u89e3\u51b3\u63d2\u5165\u7247\u6bb5\u3001\u7ed3\u6784\u53d8\u5f02\u7b49\u95ee\u9898\uff0c\u5e76\u63d0\u9ad8\u4e86\u7ed3\u6784\u6ce8\u91ca\u548c\u53d8\u5f02\u68c0\u6d4b\u7684\u51c6\u786e\u6027\u3002<o:p><\/o:p><\/p>\n<p>2.<strong> \u591a\u91cd\u6bd4\u5bf9<\/strong>\uff1a\u591a\u91cd\u6bd4\u5bf9\u662f<strong>\u6307\u5c06\u591a\u4e2a\u5e8f\u5217\u540c\u65f6\u8fdb\u884c\u6bd4\u5bf9\uff0c\u4ee5\u627e\u5230\u5b83\u4eec\u4e4b\u95f4\u7684\u5171\u540c\u6a21\u5f0f\u548c\u5171\u4eab\u7279\u5f81<\/strong>\u3002\u591a\u91cd\u6bd4\u5bf9\u901a\u5e38\u7528\u4e8e\u6bd4\u8f83\u591a\u4e2a\u76f8\u5173\u5e8f\u5217\uff08\u5982\u86cb\u767d\u8d28\u5e8f\u5217\u3001DNA\u5e8f\u5217\u6216RNA\u5e8f\u5217\uff09\u7684\u76f8\u4f3c\u6027\u548c\u5dee\u5f02\u6027\u3002\u901a\u8fc7\u591a\u91cd\u6bd4\u5bf9\uff0c\u53ef\u4ee5\u8bc6\u522b\u51fa\u5e8f\u5217\u4e4b\u95f4\u7684\u4fdd\u5b88\u533a\u57df\u3001\u53d8\u5f02\u4f4d\u70b9\u3001\u63d2\u5165\/\u5220\u9664\u4e8b\u4ef6\u7b49\u4fe1\u606f\uff0c\u4ece\u800c\u63a8\u65ad\u5e8f\u5217\u7684\u8fdb\u5316\u5173\u7cfb\u6216\u529f\u80fd\u7279\u5f81\u3002\u5e38\u7528\u7684\u591a\u91cd\u6bd4\u5bf9\u7b97\u6cd5\u5305\u62ecClustalW\u3001MAFFT\u548cMUSCLE\u7b49\u3002<o:p><\/o:p><\/p>\n<p>\u603b\u4e4b\uff0c\u6210\u5bf9\u6bd4\u5bf9\u4e3b\u8981\u7528\u4e8e\u6d4b\u5e8f\u6570\u636e\u7684\u6bd4\u5bf9\uff0c\u5bf9\u4e8e\u53cc\u7aef\u6d4b\u5e8f\u6570\u636e\u80fd\u591f\u63d0\u4f9b\u66f4\u51c6\u786e\u7684\u91cd\u5efa\u548c\u7ed3\u6784\u6ce8\u91ca\u7ed3\u679c\u3002\u800c\u591a\u91cd\u6bd4\u5bf9\u5219\u9002\u7528\u4e8e\u591a\u4e2a\u76f8\u5173\u5e8f\u5217\u7684\u6bd4\u8f83\u5206\u6790\uff0c\u7528\u4e8e\u7814\u7a76\u5e8f\u5217\u4e4b\u95f4\u7684\u76f8\u4f3c\u6027\u3001\u53d8\u5f02\u6027\u548c\u8fdb\u5316\u5173\u7cfb\u7b49\u3002<\/p>\n<p><br \/><\/p>\n<h2><\/h2>\n<h2><strong><span style=\"color: rgb(2, 30, 170);\">\u5e8f\u5217\u6bd4\u5bf9\u6838\u5fc3\u95ee\u9898\uff1a<\/span><\/strong><\/h2>\n<p>\u5e8f\u5217\u6bd4\u5bf9\u7684\u6838\u5fc3\u95ee\u9898\u662f\u5bfb\u627e<strong>\u6700\u957f\u516c\u5171\u5b50\u5e8f\u5217\uff08LCS\uff0cLongest Common Subsequence\uff09<\/strong><o:p><\/o:p><\/p>\n<p>\u5f53\u53c2\u4e0e\u6bd4\u5bf9\u7684\u5e8f\u5217\u8db3\u591f\u957f\u7684\u65f6\u5019\uff0c\u6bd4\u5bf9\u60c5\u51b5\u4f1a\u53d8\u590d\u6742\uff0c\u4e00\u6761\u5e8f\u5217\u53ef\u80fd\u540c\u65f6\u6bd4\u5bf9\u4e0a\u591a\u4e2a\u4e0d\u540c\u7684\u533a\u57df\uff0c\u5982\u4f55\u627e\u5230\u6700\u4f73\u5339\u914d\u60c5\u51b5\uff1f\u4e3e\u4e2a\u4f8b\u5b50\uff1a\u5982\u6291\u764c\u57fa\u56e0p53, \u5168\u957f\u8d85\u8fc725kb\uff0c\u6bd4\u5bf9\u60c5\u51b5\u590d\u6742\uff0c\u5982\u4f55\u8fdb\u884c\u6bd4\u5bf9\u8bc4\u4ef7\uff1f<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"1.1142857142857143\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_oAEvaale5icbpO4UKzPc2qF7mmLVSw-9.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSaXyqPOufJLOwQysye68E2sRahoAEvaale5icbpO4UKzPc2qF7mmLVSw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"560\" style=\"\" \/><\/p>\n<p><br \/><\/p>\n<p><br \/><\/p>\n<p>\u6211\u4eec\u53ef\u4ee5\u901a\u8fc7\u5bfb\u627e\u6700\u957f\u516c\u5171\u5b50\u4e32\u6216\u6700\u957f\u516c\u5171\u5b50\u5e8f\u5217\u7684\u65b9\u6cd5\u6765\u89e3\u51b3\u4e0a\u8ff0\u95ee\u9898\u3002\u4e24\u6761\u5e8f\u5217\u7684\u6700\u957f\u516c\u5171\u5b50\u5e8f\u5217\uff0c\u5c31\u662f\u6307\u8fd9\u4e24\u6761\u5e8f\u5217\u5171\u6709\u7684\u5b50\u5e8f\u5217\uff0c\u4e14\u957f\u5ea6\u6700\u957f\u3002<o:p><\/o:p><\/p>\n<p>\u4ee5\u4e0b\u8ff0\u4e24\u6761\u5e8f\u5217\u4e3a\u4f8b\uff1a<o:p><\/o:p><\/p>\n<p>GACGGATTAG<o:p><\/o:p><\/p>\n<p>GATCGGAATAG<o:p><\/o:p><\/p>\n<p>\u8fd9\u4e24\u6761\u5e8f\u5217\u7684LCS\u662fCGGA\u3002\u5f53\u7136\uff0c\u6211\u4eec\u5f88\u5bb9\u6613\u627e\u5230\u5176\u4ed6\u957f\u5ea6\u8f83\u77ed\u7684\u5b50\u5e8f\u5217\uff0c\u5982CGG\uff0cTAG\uff0c\u4f46\u5176\u4e2d\u6700\u957f\u7684\u662fCGGA\u3002\u4e00\u822c\u60c5\u51b5\u4e0b\uff0c\u53c2\u4e0e\u6bd4\u5bf9\u7684\u5e8f\u5217\u8db3\u591f\u957f\u65f6\uff0c\u53ef\u80fd\u4f1a\u51fa\u73b0\u591a\u4e2aLCS\uff0c\u4f46\u6b64\u5904LCS\u552f\u4e00\uff0c\u957f\u5ea6\u4e3a4\u3002<o:p><\/o:p><\/p>\n<p>LCS\u975e\u5e38\u6709\u52a9\u4e8e\u8ba1\u7b97\u4e24\u4e2a\u5e8f\u5217\u7684\u76f8\u4f3c\u7a0b\u5ea6\uff1aLCS\u8d8a\u957f\uff0c\u5e8f\u5217\u76f8\u4f3c\u5ea6\u8d8a\u9ad8\u3002<o:p><\/o:p><\/p>\n<p><br \/><\/p>\n<h2><span style=\"color: rgb(2, 30, 170);\"><strong>\u8ba1\u5206\u77e9\u9635\uff1a<\/strong><\/span><o:p><\/o:p><\/h2>\n<p>\u5982\u4f55\u8bbe\u8ba1\u7b97\u6cd5\uff0c\u5feb\u901f\u3001\u7cbe\u51c6\u5730\u5b8c\u6210\u957f\u5e8f\u5217\u3001\u591a\u5e8f\u5217\u7b49\u590d\u6742\u6bd4\u5bf9\u8ba1\u7b97\uff1f<o:p><\/o:p><\/p>\n<p>\u6211\u4eec\u5c06\u88ab\u6bd4\u5bf9\u5e8f\u5217\u4e4b\u95f4\u53ef\u80fd\u7684\u4f4d\u70b9\u5173\u7cfb\u8fdb\u884c\u5f52\u7eb3\uff0c\u53ef\u4ee5\u5206\u4e3a\u4ee5\u4e0b3\u7c7b\uff1a<o:p><\/o:p><\/p>\n<p>1\uff09\u5339\u914d\uff08|\uff09<o:p><\/o:p><\/p>\n<p>2\uff09\u66ff\u6362\/\u9519\u914d\uff08*\uff09<o:p><\/o:p><\/p>\n<p>3\uff09\u7a7a\u4f4d\uff08\u63d2\u5165\/\u7f3a\u5931 -\uff09<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.125\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-14_\u300c\u8f6c\u300dDNA\u751f\u4fe1\u5206\u6790\uff08\u4e94\uff09\uff1a\u5927\u795e\u4e4b\u8def\uff01\u5341\u5206\u949f\u8be6\u89e3\u5e8f\u5217\u6bd4\u5bf9\u539f\u7406\/3_K3uiar7EyIJgA47rAWTa2UUWzfm4LQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSYXEqvcF6FDIMYoYCo7HiaeAjrvK3uiar7EyIJgA47rAWTa2UUWzfm4LQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"560\" style=\"\" \/><\/p>\n<p><br \/><\/p>\n<p>\u73b0\u5728\uff0c\u6211\u4eec\u5f15\u5165\u53e6\u5916\u4e00\u4e2a\u6982\u5ff5\uff0c<strong>\u76f8\u4f3c\u6027\u3002<\/strong><o:p><\/o:p><\/p>\n<p>\u76f8\u4f3c\u6027\u7684\u610f\u4e49\u4e0e\u4e00\u81f4\u6027\u7c7b\u4f3c\uff0c\u5176\u6570\u503c\u4e5f\u662f\u7528\u6765\u8861\u91cf\u5e8f\u5217\u7684\u76f8\u4f3c\u7a0b\u5ea6\u3002\u5728\u5bf9DNA\u5e8f\u5217\u8fdb\u884c\u6bd4\u5bf9\u65f6\uff0c\u6211\u4eec\u53ef\u4ee5\u91c7\u7528\u4ee5\u4e0b\u4e09\u79cd\u4e0d\u540c\u7684<strong>\u6838\u9178\u5e8f\u5217\u66ff\u6362\u77e9\u9635\uff08\u8ba1\u5206\u77e9\u9635\uff09<\/strong>\u5bf9\u5e8f\u5217\u7684\u76f8\u4f3c\u6027\u8fdb\u884c\u6253\u5206\uff1a<o:p><\/o:p><\/p>\n<p>1.\u7b49\u4ef7\u66ff\u6362\u77e9\u9635\uff1a\u76f8\u540c\u6838\u82f7\u9178\u4e4b\u95f4\u7684\u5339\u914d\u5f97\u5206\u4e3a1\uff0c\u4e0d\u540c\u6838\u82f7\u9178\u4e4b\u95f4\u7684\u66ff\u6362\u5f97\u5206\u4e3a0\u3002\u8fd9\u79cd\u6253\u5206\u65b9\u5f0f\u7684\u4f18\u70b9\u662f\u7b80\u5355\uff0c\u4f46\u7531\u4e8e\u6ca1\u6709\u8003\u8651\u5230\u5b9e\u9645\u7684\u7edf\u8ba1\u89c4\u5f8b\u6216\u751f\u7269\u6f14\u5316\u89c4\u5f8b\uff0c\u5b9e\u9645\u5e94\u7528\u8f83\u5c11<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.8981042654028436\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_8QZRtUO9Kvq5IFSibTVe1UY47Oj39w-9.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSBib0wPEubibjBpQqico7HAyqiaetP8QZRtUO9Kvq5IFSibTVe1UY47Oj39w\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"422\" style=\"width: 307px;height: 276px;\" \/><\/p>\n<p><span style=\"\"><o:p><\/o:p><\/span><\/p>\n<p><span style=\"\"><o:p><\/o:p><\/span><\/p>\n<section powered-by=\"xiumi.us\">\n<p>2.\u8f6c\u6362-\u98a0\u6362\u77e9\u9635\uff1aDNA\u5e8f\u5217\u75314\u79cd\u57fa\u672c\u7684\u8131\u6c27\u6838\u7cd6\u6838\u82f7\u9178\u5355\u5206\u5b50\u7ec4\u6210\uff0c\u6838\u82f7\u9178\u5206\u5b50\u7684\u6838\u5fc3\u7ed3\u6784\u5dee\u5f02\u662f4\u79cd\u542b\u6c2e\u78b1\u57fa\uff0c\u5206\u522b\u662f\u817a\u560c\u5464\uff08Adenine\uff0c\u7b80\u79f0A\uff09\uff0c\u9e1f\u560c\u5464\uff08Guanine\uff0c\u7b80\u79f0G\uff09\uff0c\u80f8\u817a\u5627\u5576\uff08Thymine\uff0c\u7b80\u79f0T\uff09\uff0c\u80de\u5627\u5576\uff08Cytosine\uff0c\u7b80\u79f0C\uff09\u3002\u5728\u6570\u636e\u5206\u6790\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4eec\u5f80\u5f80\u7528\u78b1\u57fa\u5e8f\u5217\u6307\u4ee3DNA\u5e8f\u5217\u3002<strong>\u5728\u751f\u7269\u6f14\u5316\u8fc7\u7a0b\u4e2d\uff0c4\u79cd\u78b1\u57fa\u53d1\u751f\u76f8\u4e92\u66ff\u6362\u7684\u6982\u7387\u5e76\u4e0d\u5747\u7b49\uff0c\u560c\u5464\u5bb9\u6613\u88ab\u560c\u5464\u66ff\u6362\uff08A\u2194\u5934G\uff09\uff0c\u5627\u5576\u5bb9\u6613\u88ab\u5627\u5576\u66ff\u6362\uff08C\u2194T\uff09\uff0c\u8fd9\u6837\u7684\u66ff\u6362\u88ab\u79f0\u4e3a\u8f6c\u6362\uff1b\u560c\u5464\u4e0e\u5627\u5576\u4e4b\u95f4\u53d1\u751f\u66ff\u6362\uff0c\u5219\u88ab\u79f0\u4e3a\u98a0\u6362\u3002\u8f6c\u6362\u6bd4\u98a0\u6362\u66f4\u5bb9\u6613\u53d1\u751f\uff0c\u4e3a\u4f53\u73b0\u8fd9\u6837\u7684\u6f14\u5316\u89c4\u5f8b\uff0c\u5728\u5bf9\u5e8f\u5217\u6bd4\u5bf9\u8fdb\u884c\u6253\u5206\u65f6\uff0c\u901a\u5e38\u5bf9\u8f6c\u6362\u8d4b\u5206\u4e3a-1\uff0c\u5bf9\u98a0\u6362\u8d4b\u5206\u4e3a-5.<span style=\"\"><o:p><\/o:p><\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.9405286343612335\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-14_\u300c\u8f6c\u300dDNA\u751f\u4fe1\u5206\u6790\uff08\u4e94\uff09\uff1a\u5927\u795e\u4e4b\u8def\uff01\u5341\u5206\u949f\u8be6\u89e3\u5e8f\u5217\u6bd4\u5bf9\u539f\u7406\/5_e7vbV0fMSVMia7tmQLu3MJ8t4OIKxA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSH9Bdh4niaDBJ3G4jU9jfqlVt4Oe7vbV0fMSVMia7tmQLu3MJ8t4OIKxA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"454\" style=\"width: 323px;height: 304px;\" \/><\/p>\n<p><br \/><\/p>\n<ol class=\"list-paddingleft-1\" style=\"list-style-type: decimal;\">\n<li>\n<p>BLAST\u77e9\u9635\uff1a\u5728\u5b9e\u9645\u4f7f\u7528\u8fc7\u7a0b\u4e2d\uff0c\u6839\u636e\u7edf\u8ba1\u7ecf\u9a8c\uff0c\u5c06\u78b1\u57fa\u5b8c\u5168\u76f8\u540c\u7684\u60c5\u51b5\u8d4b\u5206\u4e3a5\uff0c\u6bd4\u5bf9\u4e0d\u4e0a\u7684\u60c5\u51b5\u8d4b\u5206\u4e3a-4\uff0c\u8ba1\u5206\u77e9\u9635\u8ba1\u7b97\u6240\u5f97\u7ed3\u679c\u8f83\u597d\uff0c\u56e0\u6b64\u5c06\u6b64\u65b9\u6cd5\u5e7f\u6cdb\u5e94\u7528\u4e8eDNA\u5e8f\u5217\u6bd4\u5bf9\u3002<span style=\"\"><o:p><\/o:p><\/span><\/p>\n<p><br \/><\/p>\n<\/li>\n<\/ol>\n<p style=\"text-align: center;\"><br \/><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.9018789144050104\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_dd2cQY67XicmicP1TR7E5Ax4LV9Ksg-9.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZS5VAjQvJUEZunnnJX0eQQgrgrlRdd2cQY67XicmicP1TR7E5Ax4LV9Ksg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"479\" style=\"width: 311px;height: 280px;\" \/><\/p>\n<h2><\/h2>\n<h2><span style=\"color: rgb(2, 30, 170);\"><strong>\u52a8\u6001\u89c4\u5212\u7b97\u6cd5\uff1a<\/strong><\/span><o:p><\/o:p><\/h2>\n<p>\u6211\u4eec\u5047\u8bbe\u6709\u4e24\u4e2a\u957f\u5ea6\u5206\u522b\u4e3am\u548cn\u7684\u5e8f\u5217S\u2081\u548cS\u2082\uff0c\u5176\u4e2dS\u2081=a\u2081 a\u2082 … a(m)\uff0cS\u2082=b\u2081 b\u2082 … b(n)\u3002<o:p><\/o:p><\/p>\n<p>\u6211\u4eec\u5c06\u6784\u5efa\u4e00\u4e2a\u77e9\u9635A\uff0c\u5176\u4e2d<strong>A(i,j)\u8868\u793aa\u2081 a\u2082 … a(i)\u548cb\u2081 b\u2082 … b(j)\u7684\u6700\u957f\u5171\u540c\u5b50\u5e8f\u5217\u7684\u957f\u5ea6\u3002<\/strong><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.8517857142857143\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-14_\u300c\u8f6c\u300dDNA\u751f\u4fe1\u5206\u6790\uff08\u4e94\uff09\uff1a\u5927\u795e\u4e4b\u8def\uff01\u5341\u5206\u949f\u8be6\u89e3\u5e8f\u5217\u6bd4\u5bf9\u539f\u7406\/7_Pa9WEUuhypVImkQec0uZr0IH9WK8wQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSk0Ysf3WNVd2s5qEGPtjL6qh2Pa9WEUuhypVImkQec0uZr0IH9WK8wQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"560\" style=\"width: 298px;height: 254px;\" \/><\/p>\n<p><br \/><\/p>\n<p>\u5e8f\u5217S\u2081\u662f\u7ad6\u7740\u5199\u7684\uff0cS\u2082\u662f\u6a2a\u7740\u5199\u7684\u3002\u9010\u884c\u3001\u9010\u5217\u5730\u5c06\u4ee3\u8868\u884c\u7684\u6bcf\u4e2a\u5b57\u6bcd\u4e0e\u4ee3\u8868\u5217\u7684\u6bcf\u4e2a\u5b57\u6bcd\u8fdb\u884c\u6bd4\u8f83\u3002<o:p><\/o:p><\/p>\n<p>1. \u5982\u679ca(i) = b(j)\uff0c\u90a3\u4e48\u6211\u4eec\u5c31\u627e\u5230\u4e86\u4e00\u4e2a\u5339\u914d\uff08match\uff09\u3002\u6211\u4eec\u4e3a\u5f53\u524d\u7684\u5339\u914d\u8d4b\u503c1\u5206\uff1b<o:p><\/o:p><\/p>\n<p>2. \u5982\u679ca(i)\u2260b(j)\uff0c\u90a3\u4e48\u6211\u4eec\u5c31\u6709\u4e00\u4e2a\u4e0d\u5339\u914d\uff08mismatch\uff09\u3002<o:p><\/o:p><\/p>\n<p>\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6211\u4eec\u9700\u8981\u8003\u8651\u4e24\u79cd\u53ef\u80fd\u6027\uff1a\u7531 a\u2081 … a(i)\u548cb\u2081 … b(j-1) \u5f97\u5230\u7684LCS\uff0c\u4ee5\u53ca\u7531a\u2081 … a(i-1)\u548cb\u2081 … b(j)\u7684LCS\u3002<o:p><\/o:p><\/p>\n<p>\u53ef\u7531\u4ee5\u4e0b\u516c\u5f0f\u8868\u793a\uff1a<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.19464285714285715\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_AicpticxxIhXd5cIlzWPYM8uwbXBug-9.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYz1PI4TtbNOmzwlWtgGXZSS8CHkyeVTiaUDZGcZDeEFMm5PN5AicpticxxIhXd5cIlzWPYM8uwbXBug\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"560\" style=\"\" \/><\/p>\n<p><br \/><\/p>\n<p>\u5047\u5982\u5c0f\u4f19\u4f34\u4eec\u8fd8\u662f\u4e0d\u592a\u7406\u89e3\u52a8\u6001\u89c4\u5212\u7b97\u6cd5\uff0c\u5c0f\u82b1\u5728\u8fd9\u91cc\u4e3e\u4e2a\u4f8b\u5b50\uff1a<o:p><\/o:p><\/p>\n<p>\u201c\u5728\u7eb8\u4e0a\u5199\u4e0b’1+1+1+1+1+1+1+1 =’\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u8fd9\u4e2a\u7b49\u4e8e\u591a\u5c11\uff1f\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u662f\u516b\uff01\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u5728\u5f0f\u5b50\u5de6\u8fb9\u518d\u5199\u4e00\u4e2a’1+’\u5462\uff1f\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u662f\u4e5d\uff01\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u4f60\u600e\u4e48\u80fd\u8fd9\u4e48\u5feb\u77e5\u9053\u662f\u4e5d\u7684\uff1f\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u56e0\u4e3a\u6211\u53ea\u9700\u8981\u8ba9\u516b\u518d\u52a0\u4e00\u3002\u201d<o:p><\/o:p><\/p>\n<p>\u201c\u6240\u4ee5\u4f60\u4e0d\u9700\u8981\u4ece\u5934\u5f00\u59cb\u91cd\u65b0\u6570\u6570\uff0c\u56e0\u4e3a\u4f60\u8bb0\u5f97\u539f\u6765\u662f\u516b\uff01\u52a8\u6001\u89c4\u5212\u5176\u5b9e\u5c31\u662f\u4e00\u79cd\u82b1\u54e8\u7684\u8bf4\u6cd5\uff0c\u5b83\u7684\u610f\u601d\u662f\u2018\u8bb0\u4f4f\u73b0\u5728\u4e3a\u4ee5\u540e\u7701\u65f6\u95f4\u2019\u3002\u201d<o:p><\/o:p><\/p>\n<p>\u770b\u5230\u8fd9\u91cc\uff0c\u5c0f\u82b1\u76f8\u4fe1\u5c0f\u4f19\u4f34\u4eec\u5df2\u7ecf\u7406\u89e3\u4e86\u52a8\u6001\u89c4\u5212\u7b97\u6cd5\u7684\u6838\u5fc3\u601d\u60f3\u5566\uff0c\u90a3\u4e48\u52a8\u6001\u89c4\u5212\u7b97\u6cd5\u5982\u4f55\u5e94\u7528\u5728\u5e8f\u5217\u6bd4\u5bf9\u4e2d\u5462\uff1f\u4e0d\u8981\u7740\u6025\uff0c\u6211\u4eec\u63a5\u7740\u5f80\u4e0b\u770b\uff1a<o:p><\/o:p><\/p>\n<p><br \/><\/p>\n<h2><\/h2>\n<h2><span style=\"color: rgb(2, 30, 170);\"><strong>Smith-Waterman\u7b97\u6cd5\u548cNeedleman-Wunsch\u7b97\u6cd5<\/strong><\/span><o:p><\/o:p><\/h2>\n<p>\u52a8\u6001\u89c4\u5212\u7b97\u6cd5\u5728\u5e8f\u5217\u6bd4\u5bf9\u4e2d\u6700\u8457\u540d\u7684\u5c31\u662fSmith-Waterman\u7b97\u6cd5\u548cNeedleman-Wunsch\u7b97\u6cd5\uff0c\u8fd9\u4e24\u79cd\u7b97\u6cd5\u90fd\u662f\u57fa\u4e8e\u52a8\u6001\u89c4\u5212\u7684\u601d\u60f3\uff0c\u7528\u4e8e\u5bfb\u627e\u4e24\u4e2a\u5e8f\u5217\u4e4b\u95f4\u7684\u6700\u4f73\u6bd4\u5bf9\u65b9\u6848\u3002<o:p><\/o:p><\/p>\n<p>Smith-Waterman\u7b97\u6cd5<strong>\u53ef\u4ee5\u627e\u5230\u4e24\u4e2a\u5e8f\u5217\u4e4b\u95f4\u7684\u6700\u4f73\u5c40\u90e8\u6bd4\u5bf9\u65b9\u6848\uff0c\u5373\u5728\u54ea\u4e2a\u4f4d\u7f6e\u5f00\u59cb\uff0c\u4ee5\u53ca\u4ece\u54ea\u4e2a\u4f4d\u7f6e\u7ed3\u675f\u3002<\/strong>\u4ee5\u4e0b\u662f\u7b97\u6cd5\u7684\u5177\u4f53\u6b65\u9aa4\uff1a<o:p><\/o:p><\/p>\n<p>\u2022\u6784\u5efa\u5f97\u5206\u77e9\u9635\uff1a\u6839\u636e\u7ed9\u5b9a\u7684\u5f97\u5206\u89c4\u5219\uff08\u5982\u66ff\u6362\u5f97\u5206\u3001\u7f3a\u5931\/\u63d2\u5165\u5f97\u5206\u7b49\uff09\uff0c\u6784\u5efa\u4e00\u4e2a\u5927\u5c0f\u4e3a(n+1) x (m+1)\u7684\u5f97\u5206\u77e9\u9635\uff0c\u5176\u4e2dn\u548cm\u5206\u522b\u4e3a\u4e24\u4e2a\u5e8f\u5217\u7684\u957f\u5ea6\u3002\u521d\u59cb\u5316\u5f97\u5206\u77e9\u9635\u7684\u6240\u6709\u5143\u7d20\u4e3a\u96f6\u3002<o:p><\/o:p><\/p>\n<p>\u2022\u521d\u59cb\u5316\uff1a\u5c06\u5f97\u5206\u77e9\u9635\u7684\u7b2c\u4e00\u884c\u548c\u7b2c\u4e00\u5217\u90fd\u521d\u59cb\u5316\u4e3a\u96f6\u3002\u540c\u65f6\u8bb0\u5f55\u6700\u5927\u5f97\u5206\u53ca\u5176\u6240\u5728\u7684\u4f4d\u7f6e\u3002<o:p><\/o:p><\/p>\n<p>\u2022\u586b\u5145\u5f97\u5206\u77e9\u9635\uff1a\u4ece\u5f97\u5206\u77e9\u9635\u7684\u7b2c\u4e8c\u884c\u548c\u7b2c\u4e8c\u5217\u5f00\u59cb\uff0c\u6309\u7167\u4ee5\u4e0b\u89c4\u5219\u8ba1\u7b97\u6bcf\u4e2a\u683c\u5b50\u7684\u5f97\u5206\uff1a<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u4e24\u4e2a\u5b57\u7b26\u5339\u914d\uff0c\u5c06\u5de6\u4e0a\u65b9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u5f53\u524d\u5b57\u7b26\u7684\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u4e24\u4e2a\u5b57\u7b26\u4e0d\u5339\u914d\uff0c\u5c06\u5de6\u4e0a\u65b9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u66ff\u6362\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u5b57\u7b26\u6765\u81ea\u7f3a\u5931\u5e8f\u5217\uff0c\u5c06\u5de6\u8fb9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u7f3a\u5931\/\u63d2\u5165\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u5b57\u7b26\u6765\u81ea\u63d2\u5165\u5e8f\u5217\uff0c\u5c06\u4e0a\u65b9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u7f3a\u5931\/\u63d2\u5165\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2022\u56de\u6eaf\uff1a\u4ece\u6700\u5927\u5f97\u5206\u53ca\u5176\u4f4d\u7f6e\u5f00\u59cb\uff0c\u6309\u7167\u5f97\u5206\u77e9\u9635\u4e2d\u7684\u5f97\u5206\u89c4\u5219\uff0c\u56de\u6eaf\u627e\u5230\u6700\u4f73\u7684\u6bd4\u5bf9\u8def\u5f84\uff0c\u5e76\u751f\u6210\u6700\u4f73\u6bd4\u5bf9\u5e8f\u5217\u3002<o:p><\/o:p><\/p>\n<p>Needleman-Wunsch\u7b97\u6cd5<strong>\u53ef\u4ee5\u627e\u5230\u4e24\u4e2a\u5e8f\u5217\u4e4b\u95f4\u7684\u6700\u4f73\u5168\u5c40\u6bd4\u5bf9\u65b9\u6848\uff0c\u5373\u4ece\u5e8f\u5217\u7684\u8d77\u59cb\u4f4d\u7f6e\u5230\u7ed3\u675f\u4f4d\u7f6e\u7684\u6700\u4f73\u6bd4\u5bf9\u65b9\u6848\u3002<\/strong>\u4ee5\u4e0b\u662f\u7b97\u6cd5\u7684\u5177\u4f53\u6b65\u9aa4\uff1a<o:p><\/o:p><\/p>\n<p>\u2022\u6784\u5efa\u5f97\u5206\u77e9\u9635\uff1a\u540c\u6837\u6839\u636e\u7ed9\u5b9a\u7684\u5f97\u5206\u89c4\u5219\uff0c\u6784\u5efa\u4e00\u4e2a\u5927\u5c0f\u4e3a(n+1) x (m+1)\u7684\u5f97\u5206\u77e9\u9635\uff0c\u5176\u4e2dn\u548cm\u5206\u522b\u4e3a\u4e24\u4e2a\u5e8f\u5217\u7684\u957f\u5ea6\u3002\u521d\u59cb\u5316\u5f97\u5206\u77e9\u9635\u7684\u7b2c\u4e00\u884c\u548c\u7b2c\u4e00\u5217\uff0c\u5373\u8003\u8651\u7f3a\u5931\/\u63d2\u5165\u7684\u60c5\u51b5\u3002<o:p><\/o:p><\/p>\n<p>\u2022\u586b\u5145\u5f97\u5206\u77e9\u9635\uff1a\u4ece\u5f97\u5206\u77e9\u9635\u7684\u7b2c\u4e8c\u884c\u548c\u7b2c\u4e8c\u5217\u5f00\u59cb\uff0c\u6309\u7167\u4ee5\u4e0b\u89c4\u5219\u8ba1\u7b97\u6bcf\u4e2a\u683c\u5b50\u7684\u5f97\u5206\uff1a<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u4e24\u4e2a\u5b57\u7b26\u5339\u914d\uff0c\u5c06\u5de6\u4e0a\u65b9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u5f53\u524d\u5b57\u7b26\u7684\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u4e24\u4e2a\u5b57\u7b26\u4e0d\u5339\u914d\uff0c\u5c06\u5de6\u4e0a\u65b9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u66ff\u6362\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u5b57\u7b26\u6765\u81ea\u7f3a\u5931\u5e8f\u5217\uff0c\u5c06\u5de6\u8fb9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u7f3a\u5931\/\u63d2\u5165\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2013\u5982\u679c\u5f53\u524d\u6bd4\u5bf9\u7684\u5b57\u7b26\u6765\u81ea\u63d2\u5165\u5e8f\u5217\uff0c\u5c06\u4e0a\u65b9\u683c\u5b50\u7684\u5f97\u5206\u52a0\u4e0a\u7f3a\u5931\/\u63d2\u5165\u5f97\u5206\uff0c\u4f5c\u4e3a\u5f53\u524d\u683c\u5b50\u7684\u5f97\u5206\u3002<o:p><\/o:p><\/p>\n<p>\u2022\u56de\u6eaf\uff1a\u4ece\u5f97\u5206\u77e9\u9635\u7684\u6700\u540e\u4e00\u4e2a\u683c\u5b50\u5f00\u59cb\uff0c\u6309\u7167\u5f97\u5206\u77e9\u9635\u4e2d\u7684\u5f97\u5206\u89c4\u5219\uff0c\u56de\u6eaf\u627e\u5230\u6700\u4f73\u7684\u6bd4\u5bf9\u8def\u5f84\uff0c\u5e76\u751f\u6210\u6700\u4f73\u6bd4\u5bf9\u5e8f\u5217\u3002<\/p>\n<p><span style=\"\"><o:p><\/o:p><\/span><\/p>\n<p style=\"text-align: justify;\"><br \/><\/p>\n<\/section>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 98%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;height: auto;border-style: solid;border-width: 2px;border-color: rgb(160, 160, 160);padding: 27px;\">\n<section style=\"text-align: justify;line-height: 1.6;letter-spacing: 0px;padding-right: 6px;padding-left: 6px;\" powered-by=\"xiumi.us\">\n<p><br \/><\/p>\n<\/section>\n<p><br \/><\/p>\n<p><span style=\"font-family: Cambria;font-size: 14px;\">\u770b\u5230\u8fd9\u91cc\uff0c\u5c0f\u4f19\u4f34\u4eec\u662f\u4e0d\u662f\u5df2\u7ecf\u8c41\u7136\u5f00\u6717\u4e86\u5462\uff1f\u5982\u679c\u6709\u5c0f\u4f19\u4f34\u8fd8\u6ca1\u6709\u660e\u767d\uff0c\u5c0f\u82b1\u5efa\u8bae\u53ef\u4ee5\u5148\u6309\u7167\u5c0f\u82b1\u4e0a\u4e00\u6b21\u5206\u4eab\u7684\u5185\u5bb9\u53bb\u8bd5\u7740\u505a\u4e00\u4e0b\u5e8f\u5217\u6bd4\u5bf9\u7684\u8fc7\u7a0b\uff0c\u7136\u540e\u518d\u8fd4\u56de\u6765\u7406\u89e3\u539f\u7406\u3002\u5f53\u7136\u5c0f\u4f19\u4f34\u4eec\u4e5f\u53ef\u4ee5\u7528\u5c0f\u679c\u5f00\u53d1\u7684\u751f\u4fe1\u5de5\u5177\u5e73\u53f0\uff1a<\/span><span style=\"font-family: Cambria;color: rgb(79, 129, 189);font-size: 14px;\">http:\/\/www.biocloudservice.com\/home.html<\/span><span style=\"font-size: 14px;font-family: Cambria;\">\u6765\u64cd\u4f5c\u3002\u6b63\u5982\u5c0f\u82b1\u4e00\u76f4\u8bf4\u7684\uff0c\u5f53\u5927\u5bb6\u5728\u65b0\u63a5\u89e6\u4e00\u4e2a\u77e5\u8bc6\u7684\u65f6\u5019\uff0c\u4e0e\u5176\u5148\u82b1\u8d39\u5927\u91cf\u65f6\u95f4\u6b7b\u5543\u77e5\u8bc6\u70b9\uff0c\u4e0d\u5982\u5148\u5229\u7528\u597d\u5de5\u5177\u5148\u81ea\u5df1\u4e0a\u624b\u63a5\u89e6\u6d41\u7a0b\uff0c\u5728\u8dd1\u5b8c\u4e00\u904d\u5168\u6d41\u7a0b\u540e\u518d\u8fd4\u56de\u53bb\u7406\u89e3\u77e5\u8bc6\u70b9\uff0c\u76f8\u4fe1\u53ef\u4ee5\u66f4\u597d\u66f4\u5feb\u5730\u7406\u89e3\uff0c\u8fbe\u5230\u4e8b\u534a\u529f\u500d\u7684\u6548\u679c\uff01<o:p><\/o:p><\/span><\/p>\n<p><span style=\"font-family: Cambria;font-size: 14px;\"><br \/><\/span><\/p>\n<p><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;font-family: Cambria;\"><span style=\"font-family: 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0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7434944237918215\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_DsGlqEbyCicrBvWND6p21siabffBDA-8.gif\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_gif\/KDvR2NrGicSYC5thibKicIZkAiaibGdPcbFaibyrlnYHKpXHqd0HWVnWKG2jCwfibDsGlqEbyCicrBvWND6p21siabffBDA\/640?wx_fmt=gif'\" data-type=\"gif\" data-w=\"269\" style=\"vertical-align: middle;width: 40.6667px;\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 177.948px;align-self: center;flex: 0 0 auto;\">\n<section powered-by=\"xiumi.us\" style=\"line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"178\" data-cropsely1=\"0\" data-cropsely2=\"53\" data-ratio=\"1\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-14_\u300c\u8f6c\u300dDNA\u751f\u4fe1\u5206\u6790\uff08\u4e94\uff09\uff1a\u5927\u795e\u4e4b\u8def\uff01\u5341\u5206\u949f\u8be6\u89e3\u5e8f\u5217\u6bd4\u5bf9\u539f\u7406\/10_g3QkgKRyGrcXuVcRuy0TxF7QbOA5lQ.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/KDvR2NrGicSYC5thibKicIZkAiaibGdPcbFaibOCAs16wqcbibQF52pia3AsicicM2g3QkgKRyGrcXuVcRuy0TxF7QbOA5lQ\/640?wx_fmt=jpeg'\" data-type=\"gif\" data-w=\"796\" style=\"height: 178px;vertical-align: middle;width: 178px;\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 40.6667px;align-self: center;flex: 0 0 auto;\">\n<section powered-by=\"xiumi.us\" style=\"line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.7434944237918215\" data-s=\"300,640\" 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