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href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?__biz=Mzg3OTg3MjQyNg==&action=getalbum&album_id=2664545260517294084#wechat_redirect\" title=\"\u751f\u4fe1\u5b9e\u64cd\" target=\"_blank\" rel=\"noopener\">#\u751f\u4fe1\u5b9e\u64cd<\/a><\/p>\n<\/div>\n\u5c0f\u4f19\u4f34\u505a\u751f\u5b58\u5206\u6790\u7684\u65f6\u5019\u907f\u514d\u4e0d\u4e86\u6784\u5efaCox\u56de\u5f52\u98ce\u9669\u6a21\u578b\uff0c\u5c0f\u679c\u544a\u8bc9\u5927\u5bb6\u4e00\u4e2a\u65b0\u7684\u65b9\u5f0f\uff0c\u5c0f\u4f19\u4f34\u53ef\u4ee5\u4e0d\u518d\u7528Cox\u56de\u5f52\u4e86\uff0c\u6211\u4eec\u53bb\u8bd5\u8bd5\u673a\u68b0\u5b66\u4e60\u7684\u65b9\u6cd5\u4e4b\u4e00\u968f\u673a\u68ee\u6797\u7684\u751f\u5b58\u5206\u6790\u4e5f\u5c31\u662frandomForestSRC\u3002<\/span>\u6211\u4eec\u5148\u4e86\u89e3\u4e00\u4e0b\u65b9\u6cd5\uff0c<\/span> <\/p>\n\u968f\u673a\u751f<\/span>\u5b58\u68ee\u6797\u5462\uff0c\u5176\u5b9e\u662f\u901a\u8fc7\u8bad\u7ec3\u5927\u91cf\u751f\u5b58\u6811\uff0c\u4ee5\u8868\u51b3\u7684\u5f62\u5f0f\uff0c\u4ece\u4e2a\u4f53\u6811\u4e4b\u4e2d\u52a0\u6743\u9009\u4e3e\u51fa\u6700\u7ec8\u7684\u9884\u6d4b\u7ed3\u679c\u3002<\/span><\/span><\/p>\n\u6784\u5efa\u968f\u673a\u751f\u5b58\u68ee\u6797\u5462\u4e00\u822c\u6709\u4e0b\u9762\u51e0\u4e2a\u6d41\u7a0b<\/p>\n<ol class=\"list-paddingleft-1\" style=\"list-style-type: decimal;\">\n<li style=\"font-weight: bold;\">\n<section style=\"line-height: 1.6em;margin-bottom: 16px;\">\u6a21\u578b\u901a\u8fc7\u201c\u81ea\u52a9\u6cd5\u201d\uff08Bootstrap\uff09\u5c06\u539f\u59cb\u6570\u636e\u4ee5\u6709\u653e\u56de\u7684\u5f62\u5f0f\u968f\u673a\u62bd\u53d6\u6837\u672c\uff0c\u5efa\u7acb\u6837\u672c\u5b50\u96c6\uff0c\u5e76\u5c06\u6bcf\u4e2a\u6837\u672c\u4e2d37%\u7684\u6570\u636e\u4f5c\u4e3a\u888b\u5916\u6570\u636e\uff08Out-of-Bag Data\uff09\u6392\u9664\u5728\u5916\uff1b<\/strong><\/section>\n<\/li>\n<li style=\"font-weight: bold;\">\n<section style=\"line-height: 1.6em;margin-bottom: 16px;\">\u5bf9\u6bcf\u4e00\u4e2a\u6837\u672c\u968f\u673a\u9009\u62e9\u7279\u5f81\u6784\u5efa\u5176\u5bf9\u5e94\u7684\u751f\u5b58\u6811\uff1b<\/span><\/strong><\/section>\n<\/li>\n<li style=\"font-weight: bold;\">\n<section style=\"line-height: 1.6em;margin-bottom: 16px;\">\u5229\u7528Nelson-Aalen\u6cd5\u4f30\u8ba1\u968f\u673a\u751f\u5b58\u68ee\u6797\u6a21\u578b\u7684\u603b\u7d2f\u79ef\u98ce\u9669\uff1b\u2163. \u4f7f\u7528\u888b\u5916\u6570\u636e\u8ba1\u7b97\u6a21\u578b\u51c6\u786e\u5ea6\u3002<\/strong><\/section>\n<\/li>\n<\/ol>\n\u4e0b\u9762\u6211\u4eec\u5f00\u59cb\u5427\uff0c\u6211\u4eec\u5148\u6309\u7167\u4e00\u4e0bR\u5305\uff0c\u6ca1\u6709\u7684\u5c0f\u4f19\u4f34\u5148\u5b89\u88c5\u4e00\u4e0b\u54e6<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"javascript\"><code>if<\/span> (!require<\/span>(randomForestSRC)) install.packages(\"randomForestSRC\"<\/span>)<\/span><\/code><code>if<\/span> (!require<\/span>(survival)) install.packages(\"survival\"<\/span>)<\/span><\/code><code> <\/span><\/code><code> <\/span><\/code><code>library(randomForestSRC)<\/span><\/code><code>library(survival)<\/span><\/code><\/pre>\n<\/section>\n\u6211\u4eec\u5148\u8bfb\u53d6\u4e0b\u793a\u4f8b\u6570\u636e\u770b\u770b\uff0c\u8fd9\u662fR\u5305\u81ea\u5e26\u7684<\/p>\n\u4e0b\u9762\u6211\u4eec\u7528\u8fd9\u51e0\u4e2a\u6570\u636e\u8fdb\u884c\u5b66\u4e60\u548c\u5c55\u793a<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"kotlin\"><code>data<\/span>(veteran, package<\/span> = \"randomForestSRC\"<\/span>)<\/span><\/code><code>head(veteran)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.3121272365805169\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/1_kryA2uRsoKT9IUKaJhrlqTax1mBuFg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpvHtibfUhDLxETibvZvLXpY32lskryA2uRsoKT9IUKaJhrlqTax1mBuFg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"503\" \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"kotlin\"><code>data<\/span>(pbc, package<\/span> = \"randomForestSRC\"<\/span>)<\/span><\/code><code>head(pbc)<\/span><\/code><\/pre>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"kotlin\"><code> <\/span><\/code><code>data<\/span>(wihs, package<\/span> = \"randomForestSRC\"<\/span>)<\/span><\/code><code>head(wihs)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.35267857142857145\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_xf3Cbcn5VHfbCFIQYiciaSfF26uT8Q.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycp317qjM0vcOLY1EwibsNicZribwib4Ixf3Cbcn5VHfbCFIQYiciaSfF26uT8Q\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"448\" \/><\/p>\n\u6211\u4eec\u4f7f\u7528\u80ba\u764c\u7684\u6570\u636e\u96c6\u8fdb\u884c\u5206\u6790<\/p>\n\u80ba\u764c\u7684\u4e24\u79cd\u6cbb\u7597\u65b9\u6848\u7684\u662f\u968f\u673a\u8bd5\u9a8c<\/p>\n\u4f8b\u5b50\u4e00<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"xml\"><code>v.obj <-<\/span> rfsrc<\/span>(Surv<\/span>(time<\/span>, status<\/span>) ~ .<\/span>, data<\/span> = veteran,<\/span> ntree<\/span> = 100,<\/span> nsplit<\/span> = 10,<\/span><\/span><\/span><\/code><code>na.action<\/span> = \"na.impute\"<\/span>, tree.err<\/span> = TRUE,<\/span> importance<\/span> = TRUE,<\/span> block.size<\/span> = 1)<\/span><\/span><\/code><code>###\u8bbe\u7f6e\u6811\u7684\u4e2a\u6570\u4e3a3<\/span>\uff1a<\/span><\/code><code>## plot<\/span> tree<\/span> number<\/span> 3plot<\/span>(get.tree<\/span>(v.obj<\/span>, 3<\/span>))<\/span><\/code><\/pre>\n<\/section>\n<code><\/span><\/code><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.5573770491803278\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/3_SwZUic7MfCalZJfMnEVCSwyE1mbAtg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpsnicEibLugBOq5tPhdAKE8k3gI5SwZUic7MfCalZJfMnEVCSwyE1mbAtg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"427\" \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"shell\"><code>#<\/span>##\u7ed8\u5236\u8bad\u7ec3\u68ee\u6797\u7684\u7ed3\u679c<\/span><\/span><\/code><code>#<\/span># plot results of trained forest<\/span><\/span><\/code><code>plot(v.obj)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9939759036144579\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_eQeicU9TX10VhSRwOmvKY10ibKBQzw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycprB9RmZeyEpf0mIIAtlW9HN9CMMeQeicU9TX10VhSRwOmvKY10ibKBQzw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"664\" \/><\/p>\n\u6211\u4eec\u76f4\u63a5\u7ed8\u5236\u524d10\u4e2a\u4e2a\u4f53\u7684\u751f\u5b58\u66f2\u7ebf<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"bash\"><code>#\u7ed8\u5236\u524d\u5341\u4e2a\u4e2a\u4f53\u751f\u5b58\u66f2\u7ebf<\/span><\/span><\/code><code>matplot(v.obj$time<\/span>.interest, 100 * t(v.obj$survival<\/span>.oob[1:10, ]), xlab = \"Time\"<\/span>,<\/span><\/code><code>ylab = \"Survival\"<\/span>, type<\/span> = \"l\"<\/span>, lty = 1)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.6344086021505377\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/5_l0bAIYf7Yt6icnxvkaHDicQlwbgXfQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpFm8ic8mBnJUTBbxWfdrGTrqvsM3l0bAIYf7Yt6icnxvkaHDicQlwbgXfQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"372\" \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"shell\"><code>#<\/span>#\u4f7f\u7528\u51fd\u6570plot.survival\u7ed8\u5236\u524d10\u4e2a\u4e2a\u4f53\u7684\u751f\u5b58\u66f2\u7ebf<\/span><\/span><\/code><code>plot.survival(v.obj, subset = 1:10)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9818456883509834\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/6_icIBOuSuSOFrVibXqVLM3CIpgyqWBQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpDuafoqTictnPgeUGjPIzc3KWRuHicIBOuSuSOFrVibXqVLM3CIpgyqWBQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"661\" \/><\/p>\n\u4e0b\u9762\u6211\u4eec###\u5feb\u901f\u4f18\u5316\u8001\u6570\u636e\u7684\u8282\u70b9\u5927\u5c0f##\u6700\u4f18\u7684\u751f\u5b58\u8282\u70b9\u5927\u5c0f\u6bd4\u5176\u4ed6\u5bb6\u65cf#<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"css\"><code>tune<\/span>.nodesize<\/span>(Surv<\/span>(time<\/span>, status<\/span>) ~ ., veteran<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6814516129032258\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_cqgiabtIrgIib3BXia8YJHCfrBOjDw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpiaywOW5YTia5kmIaHGrmNlGshxg2PcqgiabtIrgIib3BXia8YJHCfrBOjDw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"496\" \/><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.703056768558952\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_beKTnjoseicSQp7oOq2WC8BLjISLNw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycp37kRgK0Q1lTYhxpa2E7yTCwMwibeKTnjoseicSQp7oOq2WC8BLjISLNw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"229\" \/><\/p>\n\u4f8b\u5b502<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"nginx\"><code>vd<\/span> <- veteran<\/span><\/code><code>vd$celltype<\/span> = factor(vd$celltype<\/span>)<\/span><\/code><code>vd$diagtime<\/span> = factor(vd$diagtime<\/span>)<\/span><\/code><code>vd.obj <- rfsrc(Surv(time, status) ~ .,<\/span> vd, ntree = 100<\/span>, nodesize = 5<\/span>)<\/span><\/code><code>plot(get.tree(vd.obj, 3<\/span>))<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7039877300613497\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/9_jAUWILl2gia58PIG0WfiabI3weImNw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpQibnoR14WnQ87ML2LrFXnf2wTUujAUWILl2gia58PIG0WfiabI3weImNw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"652\" \/><\/p>\n\u4e0b\u9762\u6211\u4eec\u4f7f\u7528\u75be\u75c5\u7684\u4f8b\u5b50\u6f14\u793a<\/p>\n\u539f\u53d1\u6027\u80c6\u6c41\u6027\u809d\u786c\u5316PBC<\/p>\n\u6765\u770b\u4e00\u4e0b<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"css\"><code>pbc<\/span>.obj<\/span> <-<\/span> rfsrc<\/span>(Surv<\/span>(days<\/span>, status<\/span>) ~ ., pbc<\/span>)<\/span><\/code><code>print<\/span>(pbc<\/span>.obj<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5688073394495413\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_hYQDgPaq1cUAfEMEfrdV58v3LwRcbg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpkSBkdDds7FJ94mRxicibGVOv0BhYQDgPaq1cUAfEMEfrdV58v3LwRcbg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"545\" \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"apache\"><code>#<\/span><\/span><\/code><code>pbc<\/span>.obj2 <- rfsrc(Surv(days, status) ~ ., pbc, nsplit = 10, na.action = \"na.impute\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"apache\"><code>##\u4e0e\u4e0a\u9762\u76f8\u540c\uff0c\u4f46\u8fed\u4ee3\u4e22\u5931\u7684\u6570\u636e\u7b97\u6cd5<\/span><\/span><\/code><code>pbc<\/span>.obj3 <- rfsrc(Surv(days, status) ~ ., pbc, na.action = \"na.impute\"<\/span>, nimpute = 3)<\/span><\/code><\/pre>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"apache\"><code>## \u4f30\u7b97\u6570\u636e\u7684\u5feb\u901f\u65b9\u6cd5\uff08\u4e0d\u8fdb\u884c\u63a8\u65ad\uff09<\/span><\/span><\/code><code>pbc<\/span>.imp <- impute(Surv(days, status) ~ ., pbc, splitrule = \"random\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n\u6211\u4eec\u5bf9\u4e24\u79cd\u65b9\u6cd5\u6bd4\u8f83\u4e00\u4e0b<\/p>\n\u6bd4\u8f83RF-SRC\u548cCox\u56de\u5f52\uff0c\u8bf4\u660e\u6027\u80fd\u7684c\u6307\u6570\u548cBrier\u8bc4\u5206\u63aa\u65bd\uff0c\u5047\u8bbe\u52a0\u8f7d\u4e86\u201cpec\u201d\u548c\u201csurvival\u201d<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"php\"><code>##\u6bd4\u8f83RF-SRC\u548cCOX<\/span><\/span><\/code><code>require<\/span>(\"survival\"<\/span>)<\/span><\/code><code>require<\/span>(\"pec\"<\/span>)<\/span><\/code><code>require<\/span>(\"prodlim\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n## pec\u6240\u9700\u7684\u9884\u6d4b\u51fd\u6570<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"perl\"><code>predictSurvProb.rfsrc <- function(object, newdata, times<\/span>, ...) {<\/span><\/code><code>ptemp <- predict(object, newdata = newdata, ...)$survival<\/span><\/code><code>pos<\/span> <- sindex(jump.times = object$time.interest, eval.times = times<\/span>)<\/span><\/code><code>p <- cbind(1<\/span>, ptemp)[, pos<\/span> + 1<\/span>]<\/span><\/code><code>if<\/span> (NROW(p) != NROW(newdata) || NCOL(p) != length<\/span>(times<\/span>))<\/span><\/code><code>stop(\"Prediction failed\"<\/span>)<\/span><\/code><code>p<\/span><\/code><code>}<\/span><\/code><\/pre>\n<\/section>\n## \u6570\u636e\uff0c\u516c\u5f0f\u89c4\u8303<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"cs\"><code>data(pbc, package = \"randomForestSRC\"<\/span>)<\/span><\/code><code>pbc.na <- na.omit(pbc) ##remove NA's<\/span><\/span><\/code><code>surv.f <- as<\/span>.formula(Surv(days, status) ~ .)<\/span><\/code><code>pec.f <- as<\/span>.formula(Hist(days, status) ~ 1<\/span>)<\/span><\/code><\/pre>\n<\/section>\n## \u8fd0\u884ccox\/rfsrc\u6a21\u578b\u8fdb\u884c\u8bf4\u660e\u6211\u4eec\u4f7f\u7528\u4e86\u5c11\u91cf\u7684\u6811<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"objectivec\"><code>cox.obj <- coxph(surv.f, data = pbc.na, x = TRUE<\/span>)<\/span><\/code><code>rfsrc.obj <- rfsrc(surv.f, pbc.na, ntree = 150<\/span>)<\/span><\/code><\/pre>\n<\/section>\n## \u8ba1\u7b97\u671f\u671bBrier\u5206\u6570\u7684bootstrap\u4ea4\u53c9\u9a8c\u8bc1\u4f30\u8ba1<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"cpp\"><code>set<\/span>.seed(17743<\/span>)<\/span><\/code><code>prederror.pbc <- pec(list<\/span>(cox.obj, rfsrc.obj), data = pbc.na, formula = pec.f, splitMethod = \"bootcv\"<\/span>,<\/span><\/code><code>B = 50<\/span>)<\/span><\/code><code>print(prederror.pbc)<\/span><\/code><code>##<\/span><\/span><\/code><code> <\/span><\/code><code> <\/span><\/code><code>plot(prederror.pbc)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.874251497005988\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_zgggb0L0w89mhFAGicVjB7qZAV4qhA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpGP80UJbLWZCxYxTLicD0q7Newjzgggb0L0w89mhFAGicVjB7qZAV4qhA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"334\" \/><\/p>\n\u4e0b\u9762\u6211\u4eec\u8ba1\u7b97Cox\u56de\u5f52<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"php\"><code>#Cox<\/span><\/span><\/code><code>## \u8ba1\u7b97cox\u56de\u5f52\u7684\u888b\u5916C\u6307\u6570\u5e76\u4e0erfsrc\u8fdb\u884c\u6bd4\u8f83<\/span><\/span><\/code><code>rfsrc.obj <- rfsrc(surv.f, pbc.na)<\/span><\/code><code>cat(\"out-of-bag Cox Analysis ...\"<\/span>, \"n\"<\/span>)<\/span><\/code><code>## out-of-bag Cox Analysis ...<\/span><\/span><\/code><code>cox.err <- sapply(1<\/span>:100<\/span>, function<\/span>(b)<\/span> <\/span>{<\/span><\/code><code>if<\/span> (b%%10<\/span> == 0<\/span>)<\/span><\/code><code>cat(\"cox bootstrap:\"<\/span>, b, \"n\"<\/span>)<\/span><\/code><code>train <- sample(1<\/span>:nrow(pbc.na), nrow(pbc.na), replace = TRUE<\/span>)<\/span><\/code><code>cox.obj <- tryCatch({<\/span><\/code><code>coxph(surv.f, pbc.na[train, ])<\/span><\/code><code>}, error = function<\/span>(ex)<\/span> <\/span>{<\/span><\/code><code>NULL<\/span><\/span><\/code><code>})<\/span><\/code><code>if<\/span> (!is.null<\/span>(cox.obj)) {<\/span><\/code><code>get.cindex(pbc.na$days[-train], pbc.na$status[-train], predict(cox.obj, pbc.na[-train,<\/span><\/code><code>]))<\/span><\/code><code>} else<\/span> NA<\/span><\/code><code>})<\/span><\/code><code> <\/span><\/code><code> <\/span><\/code><code>cat(\"E:\\SXG\"<\/span>)<\/span><\/code><code>##<\/span><\/span><\/code><code>## OOB error rates<\/span><\/span><\/code><code>cat(\"tRSF : \"<\/span>, rfsrc.obj$err.rate[rfsrc.obj$ntree], \"n\"<\/span>)<\/span><\/code><code>## RSF : 0.1714494<\/span><\/span><\/code><code>cat(\"tCox regression : \"<\/span>, mean(cox.err, na.rm = TRUE<\/span>), \"n\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.28251748251748254\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/12_LbSuQ1nnbeAb2rhSBdaj0xgRVv08Mw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpygRSKfWKttKfttuBacWiasfnCLbSuQ1nnbeAb2rhSBdaj0xgRVv08Mw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"715\" \/><\/p>\n\u4e0b\u9762\u6211\u4eec\u5bf9\u751f\u5b58\u7ade\u4e89\u98ce\u9669\u6bd4\u4f8b\u6a21\u578b\u8fdb\u884c\u6784\u5efa<\/p>\n\u6765\u770b\u4e00\u4e0b<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"xml\"><code>#\u751f\u5b58\u7ade\u4e89\u98ce\u9669\u6bd4\u4f8b<\/span><\/code><code>wihs.obj <-<\/span> rfsrc<\/span>(Surv<\/span>(time<\/span>, status<\/span>) ~ .<\/span>, wihs<\/span>, nsplit<\/span> = 3,<\/span> ntree<\/span> = 100)<\/span><\/span><\/span><\/code><code>plot.competing.risk<\/span>(wihs.obj<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9431137724550899\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_PXeoaNKGEq5PmS96icrfrJMdvW6KjQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpv5libIrnnh1ADamPJG5vCWbDZkPXeoaNKGEq5PmS96icrfrJMdvW6KjQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"668\" \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"bash\"><code>cif <- wihs.obj$cif<\/span>.oob<\/span><\/code><code>Time <- wihs.obj$time<\/span>.interest<\/span><\/code><code>idu <- wihs$idu<\/span><\/span><\/code><code>cif.haart <- cbind(apply(cif[, , 1][idu == 0, ], 2, mean), apply(cif[, , 1][idu ==<\/span><\/code><code>1, ], 2, mean))<\/span><\/code><code>cif.aids <- cbind(apply(cif[, , 2][idu == 0, ], 2, mean), apply(cif[, , 2][idu ==<\/span><\/code><code>1, ], 2, mean))<\/span><\/code><code>matplot(Time, cbind(cif.haart, cif.aids), type<\/span> = \"l\"<\/span>, lty = c(1, 2, 1, 2), col = c(4,<\/span><\/code><code>4, 2, 2), lwd = 3, ylab = \"Cumulative Incidence\"<\/span>)<\/span><\/code><code>legend(\"bottomright\"<\/span>, legend = c(\"HAART (Non-IDU)\"<\/span>, \"HAART (IDU)\"<\/span>, \"AIDS (Non-IDU)\"<\/span>,<\/span><\/code><code>\"AIDS (IDU)\"<\/span>), lty = c(1, 2, 1, 2), col = c(4, 4, 2, 2), lwd = 3, cex = 0.6)#\u56fe\u6ce8<\/span><\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.5790816326530612\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/14_oJnXUyoicfXmHuVic8kU99YHulaibA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpQVxnNNscEhMicSicc9UYUEt6hMicxXoJnXUyoicfXmHuVic8kU99YHulaibA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"392\" \/><\/p>\n\u5c0f\u4f19\u4f34\u53ef\u80fd\u4e0d\u592a\u61c2\u7ed3\u679c\u7684\u542b\u4e49\uff0c\u5c0f\u679c\u8fd9\u91cc\u7b80\u5355\u89e3\u8bfb\u4e00\u4e9b<\/p>\n\u968f\u673a\u751f\u5b58\u68ee\u6797\u53ef\u4ee5\u5bf9\u53d8\u91cf\u91cd\u8981\u6027\u8fdb\u884c\u6392\u540d\uff0cVIMP\u6cd5\u548c\u6700\u5c0f\u6df1\u5ea6\u6cd5\u662f\u6700\u5e38\u7528\u7684\u65b9\u6cd5\uff1a\u53d8\u91cfVIMP\u503c\u5c0f\u4e8e0\u8bf4\u660e\u8be5\u53d8\u91cf\u964d\u4f4e\u4e86\u9884\u6d4b\u7684\u51c6\u786e\u6027\uff0c\u800c\u5f53VIMP\u503c\u5927\u4e8e0\u5219\u8bf4\u660e\u8be5\u53d8\u91cf\u63d0\u9ad8\u4e86\u9884\u6d4b\u7684\u51c6\u786e\u6027\uff1b\u6700\u5c0f\u6df1\u5ea6\u6cd5\u901a\u8fc7\u8ba1\u7b97\u8fd0\u884c\u5230\u6700\u7ec8\u8282\u70b9\u65f6\u7684\u6700\u5c0f\u6df1\u5ea6\u6765\u7ed9\u51fa\u5404\u53d8\u91cf\u5bf9\u4e8e\u7ed3\u5c40\u4e8b\u4ef6\u7684\u91cd\u8981\u6027\u3002<\/p>\n\u4e0a\u8ff0\u4e3a\u7efc\u5408\u4e24\u79cd\u65b9\u6cd5\u7684\u6563\u70b9\u56fe\uff0c\u5176\u4e2d\uff0c\u84dd\u8272\u70b9\u4ee3\u8868VIMP\u503c\u5927\u4e8e0\uff0c\u7ea2\u8272\u5219\u4ee3\u8868VIMP\u503c\u5c0f\u4e8e0\uff1b\u5728\u7ea2\u8272\u5bf9\u89d2\u865a\u7ebf\u4e0a\u7684\u70b9\u4ee3\u8868\u4e24\u79cd\u65b9\u6cd5\u5bf9\u8be5\u53d8\u91cf\u7684\u6392\u540d\u76f8\u540c\uff0c\u9ad8\u4e8e\u5bf9\u89d2\u865a\u7ebf\u7684\u70b9\u4ee3\u8868\u5176VIMP\u6392\u540d\u66f4\u9ad8\uff0c\u4f4e\u4e8e\u5bf9\u89d2\u865a\u7ebf\u7684\u70b9\u5219\u4ee3\u8868\u5176\u6700\u5c0f\u6df1\u5ea6\u6392\u540d\u66f4\u9ad8\u3002\u76f8\u8f83\u4e8eCox\u6bd4\u4f8b\u98ce\u9669\u56de\u5f52\u6a21\u578b\u7b49\u4f20\u7edf\u751f\u5b58\u5206\u6790\u65b9\u6cd5\uff0c\u968f\u673a\u751f\u5b58\u68ee\u6797\u6a21\u578b\u7684\u9884\u6d4b\u51c6\u786e\u5ea6\u81f3\u5c11\u7b49\u540c\u6216\u4f18\u4e8e\u4f20\u7edf\u751f\u5b58\u5206\u6790\u65b9\u6cd5\u3002<\/p>\n\u968f\u673a\u68ee\u6797\u5462\u5176\u5b9e\u6709\u5f88\u591a\u7684\u4f18\u52bf\uff0c\u5c0f\u679c\u8fd9\u91cc\u5c31\u4e0d\u4e00\u4e00\u4ecb\u7ecd\u4e86\uff0c\u5c0f\u4f19\u4f34\u5b66\u4f1a\u4e86\u5417\uff0c\u5c06\u81ea\u5df1\u7684\u6570\u636e\u53bb\u505a\u4e2a\u5b9e\u9a8c\uff0c\u52a8\u624b\u8bd5\u8bd5\u8fd9\u4e2a\u65b0\u65b9\u6cd5\u5427\uff01\u3001<\/p>\n\u597d\u4e86\u5c0f\u679c\u4eca\u5929\u7684\u5206\u4eab\u5c31\u5230\u8fd9\u91cc\u4e86\uff0c<\/span>\u5c0f\u4f19\u4f34\u4eec\uff0c\u4eca\u5929\u6709\u6ca1\u6709\u5b66\u5230\u65b0\u77e5\u8bc6\u5462\uff0c\u60f3\u8981\u7ee7\u7eed\u4e86\u89e3R\u8bed\u8a00\u5185\u5bb9\u53ef\u4ee5\u6301\u7eed\u5173\u6ce8\u5c0f\u679c\u54e6\uff5e\u6216\u8005\u4e5f\u53ef\u4ee5\u5173\u6ce8\u6211\u4eec\u7684\u5b98\u7f51\u4e5f\u4f1a\u6301\u7eed\u66f4\u65b0\u7684\u54e6\uff5e<\/span><\/span><\/strong><\/strong><\/p>\n<section 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{"id":55288,"date":"2024-06-16T16:24:27","date_gmt":"2024-06-16T08:24:27","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=55288"},"modified":"2024-06-16T16:24:27","modified_gmt":"2024-06-16T08:24:27","slug":"%e7%94%9f%e5%ad%98%e5%88%86%e6%9e%90%e5%88%ab%e5%8f%aa%e7%94%a8cox%e5%9b%9e%e5%bd%92%e4%ba%86%ef%bc%8c%e8%b7%9f%e7%9d%80%e5%b0%8f%e6%9e%9c%e8%af%95%e8%af%95%e9%9a%8f%e6%9c%ba%e6%a3%ae%e6%9e%97-2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=55288","title":{"rendered":"\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC"},"content":{"rendered":"

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href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?__biz=Mzg3OTg3MjQyNg==&action=getalbum&album_id=2664545260517294084#wechat_redirect\" title=\"\u751f\u4fe1\u5b9e\u64cd\" target=\"_blank\" rel=\"noopener\">#\u751f\u4fe1\u5b9e\u64cd<\/a><\/p>\n<\/div>\n\u5c0f\u4f19\u4f34\u505a\u751f\u5b58\u5206\u6790\u7684\u65f6\u5019\u907f\u514d\u4e0d\u4e86\u6784\u5efaCox\u56de\u5f52\u98ce\u9669\u6a21\u578b\uff0c\u5c0f\u679c\u544a\u8bc9\u5927\u5bb6\u4e00\u4e2a\u65b0\u7684\u65b9\u5f0f\uff0c\u5c0f\u4f19\u4f34\u53ef\u4ee5\u4e0d\u518d\u7528Cox\u56de\u5f52\u4e86\uff0c\u6211\u4eec\u53bb\u8bd5\u8bd5\u673a\u68b0\u5b66\u4e60\u7684\u65b9\u6cd5\u4e4b\u4e00\u968f\u673a\u68ee\u6797\u7684\u751f\u5b58\u5206\u6790\u4e5f\u5c31\u662frandomForestSRC\u3002<\/span>\u6211\u4eec\u5148\u4e86\u89e3\u4e00\u4e0b\u65b9\u6cd5\uff0c<\/span> 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Data\uff09\u6392\u9664\u5728\u5916\uff1b<\/strong><\/section>\n<\/li>\n<li style=\"font-weight: bold;\">\n<section style=\"line-height: 1.6em;margin-bottom: 16px;\">\u5bf9\u6bcf\u4e00\u4e2a\u6837\u672c\u968f\u673a\u9009\u62e9\u7279\u5f81\u6784\u5efa\u5176\u5bf9\u5e94\u7684\u751f\u5b58\u6811\uff1b<\/span><\/strong><\/section>\n<\/li>\n<li style=\"font-weight: bold;\">\n<section style=\"line-height: 1.6em;margin-bottom: 16px;\">\u5229\u7528Nelson-Aalen\u6cd5\u4f30\u8ba1\u968f\u673a\u751f\u5b58\u68ee\u6797\u6a21\u578b\u7684\u603b\u7d2f\u79ef\u98ce\u9669\uff1b\u2163. \u4f7f\u7528\u888b\u5916\u6570\u636e\u8ba1\u7b97\u6a21\u578b\u51c6\u786e\u5ea6\u3002<\/strong><\/section>\n<\/li>\n<\/ol>\n\u4e0b\u9762\u6211\u4eec\u5f00\u59cb\u5427\uff0c\u6211\u4eec\u5148\u6309\u7167\u4e00\u4e0bR\u5305\uff0c\u6ca1\u6709\u7684\u5c0f\u4f19\u4f34\u5148\u5b89\u88c5\u4e00\u4e0b\u54e6<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"javascript\"><code>if<\/span> (!require<\/span>(randomForestSRC)) install.packages(\"randomForestSRC\"<\/span>)<\/span><\/code><code>if<\/span> (!require<\/span>(survival)) install.packages(\"survival\"<\/span>)<\/span><\/code><code> <\/span><\/code><code> <\/span><\/code><code>library(randomForestSRC)<\/span><\/code><code>library(survival)<\/span><\/code><\/pre>\n<\/section>\n\u6211\u4eec\u5148\u8bfb\u53d6\u4e0b\u793a\u4f8b\u6570\u636e\u770b\u770b\uff0c\u8fd9\u662fR\u5305\u81ea\u5e26\u7684<\/p>\n\u4e0b\u9762\u6211\u4eec\u7528\u8fd9\u51e0\u4e2a\u6570\u636e\u8fdb\u884c\u5b66\u4e60\u548c\u5c55\u793a<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"kotlin\"><code>data<\/span>(veteran, package<\/span> = \"randomForestSRC\"<\/span>)<\/span><\/code><code>head(veteran)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.3121272365805169\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/1_kryA2uRsoKT9IUKaJhrlqTax1mBuFg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpvHtibfUhDLxETibvZvLXpY32lskryA2uRsoKT9IUKaJhrlqTax1mBuFg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"503\" \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"kotlin\"><code>data<\/span>(pbc, package<\/span> = \"randomForestSRC\"<\/span>)<\/span><\/code><code>head(pbc)<\/span><\/code><\/pre>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"kotlin\"><code> <\/span><\/code><code>data<\/span>(wihs, package<\/span> = \"randomForestSRC\"<\/span>)<\/span><\/code><code>head(wihs)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.35267857142857145\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_xf3Cbcn5VHfbCFIQYiciaSfF26uT8Q.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycp317qjM0vcOLY1EwibsNicZribwib4Ixf3Cbcn5VHfbCFIQYiciaSfF26uT8Q\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"448\" \/><\/p>\n\u6211\u4eec\u4f7f\u7528\u80ba\u764c\u7684\u6570\u636e\u96c6\u8fdb\u884c\u5206\u6790<\/p>\n\u80ba\u764c\u7684\u4e24\u79cd\u6cbb\u7597\u65b9\u6848\u7684\u662f\u968f\u673a\u8bd5\u9a8c<\/p>\n\u4f8b\u5b50\u4e00<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"xml\"><code>v.obj <-<\/span> rfsrc<\/span>(Surv<\/span>(time<\/span>, status<\/span>) ~ .<\/span>, data<\/span> = veteran,<\/span> ntree<\/span> = 100,<\/span> nsplit<\/span> = 10,<\/span><\/span><\/span><\/code><code>na.action<\/span> = \"na.impute\"<\/span>, tree.err<\/span> = TRUE,<\/span> importance<\/span> = TRUE,<\/span> block.size<\/span> = 1)<\/span><\/span><\/code><code>###\u8bbe\u7f6e\u6811\u7684\u4e2a\u6570\u4e3a3<\/span>\uff1a<\/span><\/code><code>## plot<\/span> tree<\/span> number<\/span> 3plot<\/span>(get.tree<\/span>(v.obj<\/span>, 3<\/span>))<\/span><\/code><\/pre>\n<\/section>\n<code><\/span><\/code><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.5573770491803278\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/3_SwZUic7MfCalZJfMnEVCSwyE1mbAtg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpsnicEibLugBOq5tPhdAKE8k3gI5SwZUic7MfCalZJfMnEVCSwyE1mbAtg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"427\" \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"shell\"><code>#<\/span>##\u7ed8\u5236\u8bad\u7ec3\u68ee\u6797\u7684\u7ed3\u679c<\/span><\/span><\/code><code>#<\/span># plot results of trained forest<\/span><\/span><\/code><code>plot(v.obj)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9939759036144579\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_eQeicU9TX10VhSRwOmvKY10ibKBQzw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycprB9RmZeyEpf0mIIAtlW9HN9CMMeQeicU9TX10VhSRwOmvKY10ibKBQzw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"664\" \/><\/p>\n\u6211\u4eec\u76f4\u63a5\u7ed8\u5236\u524d10\u4e2a\u4e2a\u4f53\u7684\u751f\u5b58\u66f2\u7ebf<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"bash\"><code>#\u7ed8\u5236\u524d\u5341\u4e2a\u4e2a\u4f53\u751f\u5b58\u66f2\u7ebf<\/span><\/span><\/code><code>matplot(v.obj$time<\/span>.interest, 100 * t(v.obj$survival<\/span>.oob[1:10, ]), xlab = \"Time\"<\/span>,<\/span><\/code><code>ylab = \"Survival\"<\/span>, type<\/span> = \"l\"<\/span>, lty = 1)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.6344086021505377\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/5_l0bAIYf7Yt6icnxvkaHDicQlwbgXfQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpFm8ic8mBnJUTBbxWfdrGTrqvsM3l0bAIYf7Yt6icnxvkaHDicQlwbgXfQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"372\" \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"shell\"><code>#<\/span>#\u4f7f\u7528\u51fd\u6570plot.survival\u7ed8\u5236\u524d10\u4e2a\u4e2a\u4f53\u7684\u751f\u5b58\u66f2\u7ebf<\/span><\/span><\/code><code>plot.survival(v.obj, subset = 1:10)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9818456883509834\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/6_icIBOuSuSOFrVibXqVLM3CIpgyqWBQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpDuafoqTictnPgeUGjPIzc3KWRuHicIBOuSuSOFrVibXqVLM3CIpgyqWBQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"661\" \/><\/p>\n\u4e0b\u9762\u6211\u4eec###\u5feb\u901f\u4f18\u5316\u8001\u6570\u636e\u7684\u8282\u70b9\u5927\u5c0f##\u6700\u4f18\u7684\u751f\u5b58\u8282\u70b9\u5927\u5c0f\u6bd4\u5176\u4ed6\u5bb6\u65cf#<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"css\"><code>tune<\/span>.nodesize<\/span>(Surv<\/span>(time<\/span>, status<\/span>) ~ ., veteran<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6814516129032258\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_cqgiabtIrgIib3BXia8YJHCfrBOjDw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpiaywOW5YTia5kmIaHGrmNlGshxg2PcqgiabtIrgIib3BXia8YJHCfrBOjDw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"496\" \/><\/p>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.703056768558952\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_beKTnjoseicSQp7oOq2WC8BLjISLNw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycp37kRgK0Q1lTYhxpa2E7yTCwMwibeKTnjoseicSQp7oOq2WC8BLjISLNw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"229\" \/><\/p>\n\u4f8b\u5b502<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"nginx\"><code>vd<\/span> <- veteran<\/span><\/code><code>vd$celltype<\/span> = factor(vd$celltype<\/span>)<\/span><\/code><code>vd$diagtime<\/span> = factor(vd$diagtime<\/span>)<\/span><\/code><code>vd.obj <- rfsrc(Surv(time, status) ~ .,<\/span> vd, ntree = 100<\/span>, nodesize = 5<\/span>)<\/span><\/code><code>plot(get.tree(vd.obj, 3<\/span>))<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7039877300613497\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/9_jAUWILl2gia58PIG0WfiabI3weImNw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpQibnoR14WnQ87ML2LrFXnf2wTUujAUWILl2gia58PIG0WfiabI3weImNw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"652\" \/><\/p>\n\u4e0b\u9762\u6211\u4eec\u4f7f\u7528\u75be\u75c5\u7684\u4f8b\u5b50\u6f14\u793a<\/p>\n\u539f\u53d1\u6027\u80c6\u6c41\u6027\u809d\u786c\u5316PBC<\/p>\n\u6765\u770b\u4e00\u4e0b<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"css\"><code>pbc<\/span>.obj<\/span> <-<\/span> rfsrc<\/span>(Surv<\/span>(days<\/span>, status<\/span>) ~ ., pbc<\/span>)<\/span><\/code><code>print<\/span>(pbc<\/span>.obj<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5688073394495413\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_hYQDgPaq1cUAfEMEfrdV58v3LwRcbg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpkSBkdDds7FJ94mRxicibGVOv0BhYQDgPaq1cUAfEMEfrdV58v3LwRcbg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"545\" \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"apache\"><code>#<\/span><\/span><\/code><code>pbc<\/span>.obj2 <- rfsrc(Surv(days, status) ~ ., pbc, nsplit = 10, na.action = \"na.impute\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"apache\"><code>##\u4e0e\u4e0a\u9762\u76f8\u540c\uff0c\u4f46\u8fed\u4ee3\u4e22\u5931\u7684\u6570\u636e\u7b97\u6cd5<\/span><\/span><\/code><code>pbc<\/span>.obj3 <- rfsrc(Surv(days, status) ~ ., pbc, na.action = \"na.impute\"<\/span>, nimpute = 3)<\/span><\/code><\/pre>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"apache\"><code>## \u4f30\u7b97\u6570\u636e\u7684\u5feb\u901f\u65b9\u6cd5\uff08\u4e0d\u8fdb\u884c\u63a8\u65ad\uff09<\/span><\/span><\/code><code>pbc<\/span>.imp <- impute(Surv(days, status) ~ ., pbc, splitrule = \"random\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n\u6211\u4eec\u5bf9\u4e24\u79cd\u65b9\u6cd5\u6bd4\u8f83\u4e00\u4e0b<\/p>\n\u6bd4\u8f83RF-SRC\u548cCox\u56de\u5f52\uff0c\u8bf4\u660e\u6027\u80fd\u7684c\u6307\u6570\u548cBrier\u8bc4\u5206\u63aa\u65bd\uff0c\u5047\u8bbe\u52a0\u8f7d\u4e86\u201cpec\u201d\u548c\u201csurvival\u201d<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"php\"><code>##\u6bd4\u8f83RF-SRC\u548cCOX<\/span><\/span><\/code><code>require<\/span>(\"survival\"<\/span>)<\/span><\/code><code>require<\/span>(\"pec\"<\/span>)<\/span><\/code><code>require<\/span>(\"prodlim\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n## pec\u6240\u9700\u7684\u9884\u6d4b\u51fd\u6570<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"perl\"><code>predictSurvProb.rfsrc <- function(object, newdata, times<\/span>, ...) {<\/span><\/code><code>ptemp <- predict(object, newdata = newdata, ...)$survival<\/span><\/code><code>pos<\/span> <- sindex(jump.times = object$time.interest, eval.times = times<\/span>)<\/span><\/code><code>p <- cbind(1<\/span>, ptemp)[, pos<\/span> + 1<\/span>]<\/span><\/code><code>if<\/span> (NROW(p) != NROW(newdata) || NCOL(p) != length<\/span>(times<\/span>))<\/span><\/code><code>stop(\"Prediction failed\"<\/span>)<\/span><\/code><code>p<\/span><\/code><code>}<\/span><\/code><\/pre>\n<\/section>\n## \u6570\u636e\uff0c\u516c\u5f0f\u89c4\u8303<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"cs\"><code>data(pbc, package = \"randomForestSRC\"<\/span>)<\/span><\/code><code>pbc.na <- na.omit(pbc) ##remove NA's<\/span><\/span><\/code><code>surv.f <- as<\/span>.formula(Surv(days, status) ~ .)<\/span><\/code><code>pec.f <- as<\/span>.formula(Hist(days, status) ~ 1<\/span>)<\/span><\/code><\/pre>\n<\/section>\n## \u8fd0\u884ccox\/rfsrc\u6a21\u578b\u8fdb\u884c\u8bf4\u660e\u6211\u4eec\u4f7f\u7528\u4e86\u5c11\u91cf\u7684\u6811<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"objectivec\"><code>cox.obj <- coxph(surv.f, data = pbc.na, x = TRUE<\/span>)<\/span><\/code><code>rfsrc.obj <- rfsrc(surv.f, pbc.na, ntree = 150<\/span>)<\/span><\/code><\/pre>\n<\/section>\n## \u8ba1\u7b97\u671f\u671bBrier\u5206\u6570\u7684bootstrap\u4ea4\u53c9\u9a8c\u8bc1\u4f30\u8ba1<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"cpp\"><code>set<\/span>.seed(17743<\/span>)<\/span><\/code><code>prederror.pbc <- pec(list<\/span>(cox.obj, rfsrc.obj), data = pbc.na, formula = pec.f, splitMethod = \"bootcv\"<\/span>,<\/span><\/code><code>B = 50<\/span>)<\/span><\/code><code>print(prederror.pbc)<\/span><\/code><code>##<\/span><\/span><\/code><code> <\/span><\/code><code> <\/span><\/code><code>plot(prederror.pbc)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.874251497005988\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_zgggb0L0w89mhFAGicVjB7qZAV4qhA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpGP80UJbLWZCxYxTLicD0q7Newjzgggb0L0w89mhFAGicVjB7qZAV4qhA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"334\" \/><\/p>\n\u4e0b\u9762\u6211\u4eec\u8ba1\u7b97Cox\u56de\u5f52<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"php\"><code>#Cox<\/span><\/span><\/code><code>## \u8ba1\u7b97cox\u56de\u5f52\u7684\u888b\u5916C\u6307\u6570\u5e76\u4e0erfsrc\u8fdb\u884c\u6bd4\u8f83<\/span><\/span><\/code><code>rfsrc.obj <- rfsrc(surv.f, pbc.na)<\/span><\/code><code>cat(\"out-of-bag Cox Analysis ...\"<\/span>, \"n\"<\/span>)<\/span><\/code><code>## out-of-bag Cox Analysis ...<\/span><\/span><\/code><code>cox.err <- sapply(1<\/span>:100<\/span>, function<\/span>(b)<\/span> <\/span>{<\/span><\/code><code>if<\/span> (b%%10<\/span> == 0<\/span>)<\/span><\/code><code>cat(\"cox bootstrap:\"<\/span>, b, \"n\"<\/span>)<\/span><\/code><code>train <- sample(1<\/span>:nrow(pbc.na), nrow(pbc.na), replace = TRUE<\/span>)<\/span><\/code><code>cox.obj <- tryCatch({<\/span><\/code><code>coxph(surv.f, pbc.na[train, ])<\/span><\/code><code>}, error = function<\/span>(ex)<\/span> <\/span>{<\/span><\/code><code>NULL<\/span><\/span><\/code><code>})<\/span><\/code><code>if<\/span> (!is.null<\/span>(cox.obj)) {<\/span><\/code><code>get.cindex(pbc.na$days[-train], pbc.na$status[-train], predict(cox.obj, pbc.na[-train,<\/span><\/code><code>]))<\/span><\/code><code>} else<\/span> NA<\/span><\/code><code>})<\/span><\/code><code> <\/span><\/code><code> <\/span><\/code><code>cat(\"E:\\SXG\"<\/span>)<\/span><\/code><code>##<\/span><\/span><\/code><code>## OOB error rates<\/span><\/span><\/code><code>cat(\"tRSF : \"<\/span>, rfsrc.obj$err.rate[rfsrc.obj$ntree], \"n\"<\/span>)<\/span><\/code><code>## RSF : 0.1714494<\/span><\/span><\/code><code>cat(\"tCox regression : \"<\/span>, mean(cox.err, na.rm = TRUE<\/span>), \"n\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.28251748251748254\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/12_LbSuQ1nnbeAb2rhSBdaj0xgRVv08Mw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpygRSKfWKttKfttuBacWiasfnCLbSuQ1nnbeAb2rhSBdaj0xgRVv08Mw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"715\" \/><\/p>\n\u4e0b\u9762\u6211\u4eec\u5bf9\u751f\u5b58\u7ade\u4e89\u98ce\u9669\u6bd4\u4f8b\u6a21\u578b\u8fdb\u884c\u6784\u5efa<\/p>\n\u6765\u770b\u4e00\u4e0b<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"xml\"><code>#\u751f\u5b58\u7ade\u4e89\u98ce\u9669\u6bd4\u4f8b<\/span><\/code><code>wihs.obj <-<\/span> rfsrc<\/span>(Surv<\/span>(time<\/span>, status<\/span>) ~ .<\/span>, wihs<\/span>, nsplit<\/span> = 3,<\/span> ntree<\/span> = 100)<\/span><\/span><\/span><\/code><code>plot.competing.risk<\/span>(wihs.obj<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9431137724550899\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_PXeoaNKGEq5PmS96icrfrJMdvW6KjQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpv5libIrnnh1ADamPJG5vCWbDZkPXeoaNKGEq5PmS96icrfrJMdvW6KjQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"668\" \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"bash\"><code>cif <- wihs.obj$cif<\/span>.oob<\/span><\/code><code>Time <- wihs.obj$time<\/span>.interest<\/span><\/code><code>idu <- wihs$idu<\/span><\/span><\/code><code>cif.haart <- cbind(apply(cif[, , 1][idu == 0, ], 2, mean), apply(cif[, , 1][idu ==<\/span><\/code><code>1, ], 2, mean))<\/span><\/code><code>cif.aids <- cbind(apply(cif[, , 2][idu == 0, ], 2, mean), apply(cif[, , 2][idu ==<\/span><\/code><code>1, ], 2, mean))<\/span><\/code><code>matplot(Time, cbind(cif.haart, cif.aids), type<\/span> = \"l\"<\/span>, lty = c(1, 2, 1, 2), col = c(4,<\/span><\/code><code>4, 2, 2), lwd = 3, ylab = \"Cumulative Incidence\"<\/span>)<\/span><\/code><code>legend(\"bottomright\"<\/span>, legend = c(\"HAART (Non-IDU)\"<\/span>, \"HAART (IDU)\"<\/span>, \"AIDS (Non-IDU)\"<\/span>,<\/span><\/code><code>\"AIDS (IDU)\"<\/span>), lty = c(1, 2, 1, 2), col = c(4, 4, 2, 2), lwd = 3, cex = 0.6)#\u56fe\u6ce8<\/span><\/span><\/code><\/pre>\n<\/section>\n<img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.5790816326530612\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-09-25_\u751f\u5b58\u5206\u6790\u522b\u53ea\u7528Cox\u56de\u5f52\u4e86\uff0c\u8ddf\u7740\u5c0f\u679c\u8bd5\u8bd5\u968f\u673a\u68ee\u6797\u751f\u5b58\u5206\u6790\uff01-randomForestSRC\/14_oJnXUyoicfXmHuVic8kU99YHulaibA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpQVxnNNscEhMicSicc9UYUEt6hMicxXoJnXUyoicfXmHuVic8kU99YHulaibA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"392\" \/><\/p>\n\u5c0f\u4f19\u4f34\u53ef\u80fd\u4e0d\u592a\u61c2\u7ed3\u679c\u7684\u542b\u4e49\uff0c\u5c0f\u679c\u8fd9\u91cc\u7b80\u5355\u89e3\u8bfb\u4e00\u4e9b<\/p>\n\u968f\u673a\u751f\u5b58\u68ee\u6797\u53ef\u4ee5\u5bf9\u53d8\u91cf\u91cd\u8981\u6027\u8fdb\u884c\u6392\u540d\uff0cVIMP\u6cd5\u548c\u6700\u5c0f\u6df1\u5ea6\u6cd5\u662f\u6700\u5e38\u7528\u7684\u65b9\u6cd5\uff1a\u53d8\u91cfVIMP\u503c\u5c0f\u4e8e0\u8bf4\u660e\u8be5\u53d8\u91cf\u964d\u4f4e\u4e86\u9884\u6d4b\u7684\u51c6\u786e\u6027\uff0c\u800c\u5f53VIMP\u503c\u5927\u4e8e0\u5219\u8bf4\u660e\u8be5\u53d8\u91cf\u63d0\u9ad8\u4e86\u9884\u6d4b\u7684\u51c6\u786e\u6027\uff1b\u6700\u5c0f\u6df1\u5ea6\u6cd5\u901a\u8fc7\u8ba1\u7b97\u8fd0\u884c\u5230\u6700\u7ec8\u8282\u70b9\u65f6\u7684\u6700\u5c0f\u6df1\u5ea6\u6765\u7ed9\u51fa\u5404\u53d8\u91cf\u5bf9\u4e8e\u7ed3\u5c40\u4e8b\u4ef6\u7684\u91cd\u8981\u6027\u3002<\/p>\n\u4e0a\u8ff0\u4e3a\u7efc\u5408\u4e24\u79cd\u65b9\u6cd5\u7684\u6563\u70b9\u56fe\uff0c\u5176\u4e2d\uff0c\u84dd\u8272\u70b9\u4ee3\u8868VIMP\u503c\u5927\u4e8e0\uff0c\u7ea2\u8272\u5219\u4ee3\u8868VIMP\u503c\u5c0f\u4e8e0\uff1b\u5728\u7ea2\u8272\u5bf9\u89d2\u865a\u7ebf\u4e0a\u7684\u70b9\u4ee3\u8868\u4e24\u79cd\u65b9\u6cd5\u5bf9\u8be5\u53d8\u91cf\u7684\u6392\u540d\u76f8\u540c\uff0c\u9ad8\u4e8e\u5bf9\u89d2\u865a\u7ebf\u7684\u70b9\u4ee3\u8868\u5176VIMP\u6392\u540d\u66f4\u9ad8\uff0c\u4f4e\u4e8e\u5bf9\u89d2\u865a\u7ebf\u7684\u70b9\u5219\u4ee3\u8868\u5176\u6700\u5c0f\u6df1\u5ea6\u6392\u540d\u66f4\u9ad8\u3002\u76f8\u8f83\u4e8eCox\u6bd4\u4f8b\u98ce\u9669\u56de\u5f52\u6a21\u578b\u7b49\u4f20\u7edf\u751f\u5b58\u5206\u6790\u65b9\u6cd5\uff0c\u968f\u673a\u751f\u5b58\u68ee\u6797\u6a21\u578b\u7684\u9884\u6d4b\u51c6\u786e\u5ea6\u81f3\u5c11\u7b49\u540c\u6216\u4f18\u4e8e\u4f20\u7edf\u751f\u5b58\u5206\u6790\u65b9\u6cd5\u3002<\/p>\n\u968f\u673a\u68ee\u6797\u5462\u5176\u5b9e\u6709\u5f88\u591a\u7684\u4f18\u52bf\uff0c\u5c0f\u679c\u8fd9\u91cc\u5c31\u4e0d\u4e00\u4e00\u4ecb\u7ecd\u4e86\uff0c\u5c0f\u4f19\u4f34\u5b66\u4f1a\u4e86\u5417\uff0c\u5c06\u81ea\u5df1\u7684\u6570\u636e\u53bb\u505a\u4e2a\u5b9e\u9a8c\uff0c\u52a8\u624b\u8bd5\u8bd5\u8fd9\u4e2a\u65b0\u65b9\u6cd5\u5427\uff01\u3001<\/p>\n\u597d\u4e86\u5c0f\u679c\u4eca\u5929\u7684\u5206\u4eab\u5c31\u5230\u8fd9\u91cc\u4e86\uff0c<\/span>\u5c0f\u4f19\u4f34\u4eec\uff0c\u4eca\u5929\u6709\u6ca1\u6709\u5b66\u5230\u65b0\u77e5\u8bc6\u5462\uff0c\u60f3\u8981\u7ee7\u7eed\u4e86\u89e3R\u8bed\u8a00\u5185\u5bb9\u53ef\u4ee5\u6301\u7eed\u5173\u6ce8\u5c0f\u679c\u54e6\uff5e\u6216\u8005\u4e5f\u53ef\u4ee5\u5173\u6ce8\u6211\u4eec\u7684\u5b98\u7f51\u4e5f\u4f1a\u6301\u7eed\u66f4\u65b0\u7684\u54e6\uff5e<\/span><\/span><\/strong><\/strong><\/p>\n<section 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