{"id":55810,"date":"2024-06-16T17:14:35","date_gmt":"2024-06-16T09:14:35","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=55810"},"modified":"2024-06-16T17:14:35","modified_gmt":"2024-06-16T09:14:35","slug":"advanced-science%ef%bc%81%e6%9c%ba%e5%99%a8%e5%ad%a6%e4%b9%a0%e4%b8%8d%e6%84%a7%e6%98%af%e6%9c%80%e5%bc%ba%e8%be%85%e5%8a%a9%ef%bc%8c%e5%b7%a8%e5%99%ac%e7%bb%86%e8%83%9e%e5%8d%95%e7%bb%86%e8%83%9e","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=55810","title":{"rendered":"Advanced Science\uff01\u673a\u5668\u5b66\u4e60\u4e0d\u6127\u662f\u6700\u5f3a\u8f85\u52a9\uff0c\u5de8\u566c\u7ec6\u80de+\u5355\u7ec6\u80de\u6d4b\u5e8f\u62ff\u634f\u5f97\u6b7b\u6b7b\u7684\uff01\u601d\u8def\u544a\u6025\u5c31\u770b\u6d59\u5927\u8d75\u9e4f\u56e2\u961f\u8fd9\u7bc7\u6587\u7ae0\uff01"},"content":{"rendered":"


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Science\uff01\u673a\u5668\u5b66\u4e60\u4e0d\u6127\u662f\u6700\u5f3a\u8f85\u52a9\uff0c\u5de8\u566c\u7ec6\u80de+\u5355\u7ec6\u80de\u6d4b\u5e8f\u62ff\u634f\u5f97\u6b7b\u6b7b\u7684\uff01\u601d\u8def\u544a\u6025\u5c31\u770b\u6d59\u5927\u8d75\u9e4f\u56e2\u961f\u8fd9\u7bc7\u6587\u7ae0\uff01<\/a><\/h1>\n<div id=\"meta_content\" class=\"rich_media_meta_list\"><span class=\"rich_media_meta rich_media_meta_text\">\u5c0f\u679c  <\/span><span class=\"rich_media_meta rich_media_meta_nickname\" id=\"profileBt\"><a href=\"javascript:void(0);\" class=\"wx_tap_link js_wx_tap_highlight weui-wa-hotarea\" id=\"js_name\">\u751f\u4fe1\u679c  <\/a><\/span><em id=\"publish_time\" class=\"rich_media_meta rich_media_meta_text\">2024-05-17 19:00:28<\/em><\/div>\n<p><content><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100015224\" data-ratio=\"0.2222222222222222\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_r0Gd7iaumIGMiaia97aHFV15nrpdzw-115.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxQW8Zek7Noib2uBhB3ZE3yMxI2Hfic7cGTdPYiacicg47jficdr5BVr0Gd7iaumIGMiaia97aHFV15nrpdzw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"900\" style=\"\" \/><\/p>\n<p style=\"outline: 0px;line-height: 25.5px;\"><span style=\"letter-spacing: 0.034em;outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">Hey\uff01\u9986\u957f\u6765\u5566\uff01\u8fd9\u6b21\u89c1\u9762\uff0c\u9986\u957f\u8981\u7ed9\u5c0f\u4f19\u4f34\u4eec\u5e26\u6765\u70b9\u4e0d\u4e00\u6837\u7684\u77e5\u8bc6\uff01\u6cdb\u764c\u7814\u7a76\u662f\u4e00\u79cd\u7efc\u5408\u6027\u7684\u79d1\u7814\u65b9\u6cd5\uff0c\u6d89\u53ca\u5bf9\u591a\u79cd\u7c7b\u578b\u764c\u75c7\u7684\u5171\u540c\u7279\u5f81\u548c\u5dee\u5f02\u6027\u8fdb\u884c\u7cfb\u7edf\u6027\u5206\u6790\u3002\u6211\u4eec\u90fd\u77e5\u9053\uff0c\u5de8\u566c\u7ec6\u80de\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u800c\u6cdb\u764c\u7814\u7a76\u5219\u53ef\u901a\u8fc7\u591a\u7ec4\u5b66\u6570\u636e\u6574\u5408\u548c\u5355\u7ec6\u80de\u5206\u6790\u7b49\u6280\u672f\uff0c\u63ed\u793a\u5de8\u566c\u7ec6\u80de\u5728\u4e0d\u540c\u764c\u75c7\u4e2d\u7684\u591a\u6837\u6027\u548c\u590d\u6742\u6027\u3002<\/span><span style=\"letter-spacing: 0.034em;outline: 0px;font-size: 12pt;line-height: 24px;font-family: 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var(--weui-LINK);cursor: pointer;\">Advanced Science<\/span><span style=\"outline: 0px;\">\u300b\uff08IF-15.1\uff09\u7684\u6587\u7ae0\uff0c\u4fbf\u5229\u7528\u673a\u5668\u5b66\u4e60\u8054\u5408\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff0c\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u89c1\u89e3\uff0c\u6784\u5efa\u4e86\u80fd\u4e00\u79cd\u9884\u6d4b\u6cdb\u764c\u60a3\u8005ICI\u6cbb\u7597\u7684M.Sig\u6a21\u578b\uff01\u73b0\u5728\u8ddf\u7740\u9986\u957f\u4e00\u8d77\u8d70\u8fd1\u8fd9\u7bc7\u9ad8\u5f71\u54cd\u6587\u7ae0\uff0c\u770b\u770b\u5b83\u7a76\u7adf\u6709\u600e\u6837\u7684\u9b45\u529b\u5427~<\/span><\/span><\/p>\n<p style=\"outline: 0px;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">1\u3001\u672c\u7814\u7a76\u805a\u7126\u4e8e<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u54cd\u5e94\u9884\u6d4b<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\uff0c\u901a\u8fc7\u63a2\u7d22<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+\u8017\u7aedT\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\uff0c\u4e3a\u7406\u89e3ICI\u6cbb\u7597\u53cd\u5e94\u7684\u673a\u5236\u63d0\u4f9b\u4e86\u65b0\u89c6\u89d2\u3002<\/span><\/p>\n<p style=\"outline: 0px;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">2\u3001\u672c\u7814\u7a76\u7ed3\u5408<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u548c\u673a\u5668\u5b66\u4e60\u7b97\u6cd5<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\uff0c\u5728\u7ec6\u80de\u5c42\u9762\u4e0a\u89e3\u6790\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u590d\u6742\u76f8\u4e92\u4f5c\u7528\u3002\u901a\u8fc7\u7efc\u5408\u5206\u6790\u5927\u91cf\u6570\u636e\uff0c\u7814\u7a76\u8005\u4eec\u6784\u5efa\u4e86M.Sig\u6a21\u578b\uff0c\u5e76\u5229\u7528\u771f\u5b9e\u4e16\u754c\u7684\u514d\u75ab\u6cbb\u7597\u6570\u636e\u8fdb\u884c\u4e86\u6709\u6548\u7684\u9a8c\u8bc1\uff0c\u5c55\u793a\u4e86\u5176\u65b9\u6cd5\u7684\u4e25\u8c28\u6027\u548c\u521b\u65b0\u6027\u3002\uff08ps\uff1a<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(255, 0, 0);font-weight: bold;\">\u60f3\u8ba9\u4f60\u7684\u7814\u7a76\u8bfe\u9898\u7cbe\u51c6\u547d\u4e2d\uff0c\u8bba\u6587\u53d1\u8868\u5982\u63a2\u56ca\u53d6\u7269\uff1f\u522b\u6025\uff0c\u9986\u957f\u6765\u5e2e\u5fd9\uff01\u5404\u79cd\u751f\u4fe1\u5206\u6790\u4e00\u7f51\u6253\u5c3d\uff0c\u800c\u4e14\u8fd8\u6709\u7269\u7f8e\u4ef7\u5ec9\u7684\u673a\u5668\u5b66\u4e60\u8bfe\u7a0b\u4e3a\u4f60\u52a9\u653b\uff01<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\uff09<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100006476\" data-ratio=\"1\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_f6PG40Qrdu5e9B1iaIMItPiajABYWA-51.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxqaqPbQprPd4vw8Ytp0cprbzXiakMDdFriaB6B59ibhlBCrNyQFf6PG40Qrdu5e9B1iaIMItPiajABYWA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 178px;height: 178px;\" \/><span style=\"font-family: \u5b8b\u4f53;font-size: 12pt;letter-spacing: 0.034em;text-align: justify;\"><\/span><\/p>\n<p style=\"outline: 0px;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018365\" data-ratio=\"0.39867424242424243\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_Bk93IfiasuYAkSWwtZnPgd8bOM0icA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6tIZjBOyAQllI5Esnaq80MukjEB3TujV3fGDmlODOqowzQgibBk93IfiasuYAkSWwtZnPgd8bOM0icA\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"1056\" height=\"220.739990234375\" style=\"outline: 0px;visibility: visible !important;width: 553.734px !important;\" width=\"553.739990234375\" \/><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/p>\n<p style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 21pt;outline: 0px;font-size: 10.5pt;font-family: \u7b49\u7ebf;text-indent: -21pt;line-height: 21px;\"><span style=\"outline: 0px;font-family: Wingdings;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(237, 125, 49);\">l<span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-stretch: normal;font-size: 7pt;line-height: normal;font-family: "Times New Roman";\"><\/span><\/span><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u9898\u76ee\uff1a\u6cdb\u764c\u75c7\u5355\u7ec6\u80de\u548c\u7a7a\u95f4\u5206\u8fa8\u56fe\u8c31\u5206\u6790\u63ed\u793a APOE+ \u5de8\u566c\u7ec6\u80de\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7597\u6cd5\u4e2d\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528<\/span><\/p>\n<p style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 21pt;outline: 0px;font-size: 10.5pt;font-family: \u7b49\u7ebf;text-indent: -21pt;line-height: 21px;\"><span style=\"outline: 0px;font-family: Wingdings;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(237, 125, 49);\">l<span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-stretch: normal;font-size: 7pt;line-height: normal;font-family: "Times New Roman";\"><\/span><\/span><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u6742\u5fd7\uff1aAdvanced Science<\/span><\/p>\n<p style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 21pt;outline: 0px;font-size: 10.5pt;font-family: \u7b49\u7ebf;text-indent: -21pt;line-height: 21px;\"><span style=\"outline: 0px;font-family: Wingdings;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(237, 125, 49);\">l<span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-stretch: normal;font-size: 7pt;line-height: normal;font-family: "Times New Roman";\"><\/span><\/span><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=15.1<\/span><\/p>\n<p style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 21pt;outline: 0px;font-size: 10.5pt;font-family: \u7b49\u7ebf;text-indent: -21pt;line-height: 21px;\"><span style=\"outline: 0px;font-family: Wingdings;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(237, 125, 49);\">l<span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-stretch: normal;font-size: 7pt;line-height: normal;font-family: "Times New Roman";\"><\/span><\/span><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e744\u6708<\/span><\/p>\n<p style=\"outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;color: rgb(0, 82, 255);\">\u7814\u7a76\u80cc\u666f<\/span><\/p>\n<p style=\"outline: 0px;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICIs\uff09\u5df2\u7ecf\u6210\u4e3a\u591a\u79cd\u764c\u75c7\u6cbb\u7597\u7b56\u7565\u7684\u4e3b\u6d41\uff0c\u5305\u62ec\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u548c\u80c3\u80a0\u764c\u7b49\u3002\u7136\u800c\uff0c\u5c3d\u7ba1ICIs\u5728\u6cbb\u7597\u67d0\u4e9b\u764c\u75c7\u65b9\u9762\u663e\u793a\u51fa\u4e86\u663e\u8457\u7684\u7597\u6548\uff0c\u4f46\u4e34\u5e8a\u5e94\u7528\u4e2d\u4ecd\u5b58\u5728\u4e00\u4e9b\u9650\u5236\uff0c\u5982\u6709\u9650\u7684\u54cd\u5e94\u7387\u548c\u4e00\u4e9b\u526f\u4f5c\u7528\u3002\u8fd9\u4e9b\u9650\u5236\u4fc3\u4f7f\u7814\u7a76\u8005\u5f00\u53d1\u751f\u7269\u6807\u5fd7\u7269\u6765\u9884\u6d4b\u5bf9\u514d\u75ab\u7597\u6cd5\u7684\u53cd\u5e94\uff0c\u5e76\u4f18\u5316\u6cbb\u7597\u65b9\u6848\u4ee5\u514b\u670d\u514d\u75ab\u62b5\u6297\u3002\u4f20\u7edf\u7684\u751f\u7269\u6807\u5fd7\u7269\u7814\u7a76\u4e3b\u8981\u5173\u6ce8\u80bf\u7624\u7ec4\u7ec7\u7684\u5168\u5916\u663e\u5b50\u6d4b\u5e8f\uff08WES\uff09\u6216RNA\u6d4b\u5e8f\uff08RNA-seq\uff09\uff0c\u4f46\u8fd9\u4e9b\u65b9\u6cd5\u4ec5\u53cd\u6620\u4e86\u80bf\u7624\u7684\u5e73\u5747\u9057\u4f20\u7279\u5f81\uff0c\u5982\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u914d\u4f531\uff08PD-L1\uff09\u7684\u8868\u8fbe\u3001\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09\u548c\u80bf\u7624\u7a81\u53d8\u8d1f\u62c5\uff08TMB\uff09\u3002\u6700\u8fd1\uff0c\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u6280\u672f\u7684\u53d1\u5c55\u4e3a\u5728\u7ec6\u80de\u6c34\u5e73\u4e0a\u5206\u6790\u57fa\u56e0\u8868\u8fbe\u63d0\u4f9b\u4e86\u591a\u79cd\u6280\u672f\uff0c\u6709\u52a9\u4e8e\u8bc6\u522b\u66f4\u654f\u611f\u7684\u6807\u8bb0\u7269\u3002<\/span><\/p>\n<p style=\"outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;color: rgb(0, 82, 255);\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u7814\u7a76\u601d\u8def<\/span><\/span><o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<p style=\"outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018363\" data-ratio=\"1.6862745098039216\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_g14xxLfmQWXW47gafL2ntB3lcGiaoQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6tIZjBOyAQllI5Esnaq80M7x7EY590CMmgJpEMEhDFpl8xwg14xxLfmQWXW47gafL2ntB3lcGiaoQ\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"357\" height=\"602.0900268554688\" style=\"outline: 0px;visibility: visible !important;width: 357.047px !important;\" width=\"357.05999755859375\" \/><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/p>\n<p style=\"outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;color: rgb(0, 82, 255);\">\u4e3b\u8981\u7ed3\u679c<\/span><\/p>\n<p style=\"outline: 0px;text-align: left;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">1\u3001\u4e00\u4e2a\u57fa\u4e8e\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6570\u636e\u548c\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u7684M.Sig\u6a21\u578b\u80fd\u591f\u6709\u6548\u9884\u6d4b\u6cdb\u764c\u60a3\u8005\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u6cbb\u7597\u7684\u53cd\u5e94\u548c\u9884\u540e<\/span><\/p>\n<p style=\"outline: 0px;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u901a\u8fc7\u6574\u5408\u5355\u7ec6\u80deRNA\u6d4b\u5e8f(scRNA-seq)\u548c\u6279\u91cfRNA\u6d4b\u5e8f\u6570\u636e\uff0c\u7814\u7a76\u8005\u6784\u5efa\u4e86\u4e00\u4e2a\u9884\u6d4b\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242(ICI)\u6cbb\u7597\u53cd\u5e94\u7684M.Sig\u6a21\u578b\u3002\u968f\u540e\uff0c\u4ed6\u4eec\u5229\u7528\u4e86\u516b\u79cd\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u5bf9\u6a21\u578b\u8fdb\u884c\u8bad\u7ec3\u548c\u4f18\u5316\uff0c\u5e76\u901a\u8fc7\u4ea4\u53c9\u9a8c\u8bc1(CV)\u6765\u7cbe\u7ec6\u5316\u6a21\u578b\u53c2\u6570\u3002\u5728\u8bad\u7ec3\u96c6\u4e2d\uff0c<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u652f\u6301\u5411\u91cf\u673a(SVM)\u6a21\u578b\u5c55\u73b0\u4e86\u6700\u9ad8\u7684\u533a\u57df\u4e0b\u66f2\u7ebf(AUC)\u503c\uff0c\u8fbe\u5230\u4e860.72\uff0c\u88ab\u9009\u4e3a\u6700\u7ec8\u6a21\u578b<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u3002\u5728\u9a8c\u8bc1\u96c6\u4e2d\uff0c<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u8be5\u6a21\u578b\u7684AUC\u503c\u4fdd\u6301\u57280.74\uff0c\u663e\u793a\u4e86\u6a21\u578b\u7684\u7a33\u5b9a\u6027\u548c\u6709\u6548\u6027<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8005\u8fd8\u901a\u8fc7\u7279\u5f81\u6392\u540d\u8ba1\u7b97\u4e86AUC\u503c\uff0c\u5e76\u5b9a\u4e49\u4e86\u5305\u542b35\u4e2a\u7279\u5f81\u7684M.Sig\u6a21\u578b\u3002<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u8be5\u6a21\u578b\u5728\u8bad\u7ec3\u96c6\u548c\u9a8c\u8bc1\u96c6\u4e2d\u7684AUC\u503c\u4e0e\u4e4b\u524d\u76f8\u6bd4\u53d8\u5316\u4e0d\u5927\uff0c\u8868\u660e\u6a21\u578b\u5177\u6709\u8f83\u597d\u7684\u6cdb\u5316\u80fd\u529b<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u3002\u901a\u8fc7\u6bd4\u8f83M.Sig\u6a21\u578b\u4e0e\u5176\u4ed613\u4e2a\u5df2\u77e5\u7684\u514d\u75ab\u76f8\u5173\u7b7e\u540d\uff0c\u7814\u7a76\u8005\u53d1\u73b0M.Sig\u6a21\u578b\u5728\u8bad\u7ec3\u96c6\u548c\u9a8c\u8bc1\u96c6\u4e2d\u7684AUC\u503c\u5747\u9ad8\u4e8e\u5176\u4ed6\u6a21\u578b\uff0c\u8bc1\u5b9e\u4e86M.Sig\u6a21\u578b\u5728\u9884\u6d4bICI\u6cbb\u7597\u53cd\u5e94\u65b9\u9762\u7684\u4f18\u8d8a\u6027\u3002<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<section style=\"margin-bottom: 8px;outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018367\" data-ratio=\"1.3046296296296296\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_aoNB9LD1h2V8U3s5ialiaW1iamicHg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6tIZjBOyAQllI5Esnaq80MHUwUkOhvYxedckDqplMRjt7kuI3LiaoNB9LD1h2V8U3s5ialiaW1iamicHg\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"1080\" height=\"767.22998046875\" style=\"outline: 0px;visibility: visible !important;width: 588.125px !important;\" width=\"588.1400146484375\" \/><\/span><\/section>\n<p style=\"outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-size: 10pt;font-weight: bold;letter-spacing: 0.034em;\">\u56fe1 \u6a21\u578b\u6784\u5efa\u7684\u5de5\u4f5c\u6d41\u7a0b\u3001\u4e0d\u540c\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u7684AUC\u503c\u6bd4\u8f83<\/span><\/p>\n<p style=\"outline: 0px;text-align: left;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\"><span style=\"outline: 0px;\">2\u3001\u5728<\/span><span class=\"wx_search_keyword_wrap\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;\">\u4e09\u9634\u6027\u4e73\u817a\u764c<\/span><span style=\"outline: 0px;\">\uff08TNBC\uff09\u4e2d\uff0c\u975e\u54cd\u5e94\u8005\u4e2dAPOE+\u5de8\u566c\u7ec6\u80de\u7684\u6bd4\u4f8b\u6bd4\u54cd\u5e94\u8005\u9ad8<\/span><\/span><\/p>\n<p style=\"outline: 0px;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u901a\u8fc7\u4f7f\u7528t-\u5206\u5e03\u968f\u673a\u90bb\u57df\u5d4c\u5165\uff08tSNE\uff09\u6280\u672f\u5bf9\u5de8\u566c\u7ec6\u80de\u8fdb\u884c\u964d\u7ef4\u5904\u7406\uff0c\u7814\u7a76\u8005\u80fd\u591f\u5c06\u5de8\u566c\u7ec6\u80de\u7ec6\u5206\u4e3a\u4e0d\u540c\u7684\u4e9a\u7fa4\uff0c\u5e76\u53d1\u73b0\u5728ICI\u6cbb\u7597\u7684\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u60a3\u8005\u4e2d\uff0c<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u975e\u54cd\u5e94\u8005\u4f53\u5185APOE+\u5de8\u566c\u7ec6\u80de\u7684\u6bd4\u4f8b\u663e\u8457\u9ad8\u4e8e\u54cd\u5e94\u8005<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u591a\u8def\u514d\u75ab\u7ec4\u5316\uff08multiplex immunohistochemistry, mIHC\uff09\u5206\u6790\uff0c\u7814\u7a76\u8005\u8fdb\u4e00\u6b65\u786e\u8ba4\u4e86APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+\u8017\u7aedT\u7ec6\u80de\uff08Tex\uff09\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u79cd\u4f5c\u7528\u53ef\u80fd\u901a\u8fc7\u514d\u75ab\u6291\u5236\u673a\u5236\u5f71\u54cdICI\u6cbb\u7597\u7684\u6548\u679c\u3002\u7814\u7a76\u8005\u8fd8\u89c2\u5bdf\u5230\uff0c<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u5728\u54cd\u5e94\u8005\u4e2d\uff0cAPOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ Tex\u7ec6\u80de\u4e4b\u95f4\u7684\u8ddd\u79bb\u8f83\u975e\u54cd\u5e94\u8005\u66f4\u957f\uff0c\u800c\u5728\u975e\u54cd\u5e94\u8005\u4e2d\uff0c\u8fd9\u4e9b\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u66f4\u4e3a\u7d27\u5bc6<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u3002<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<section style=\"margin-bottom: 8px;outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018370\" data-ratio=\"1.0055555555555555\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_uLCib9aU6ZKrOlCDPBFpRTWVTwibwQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6tIZjBOyAQllI5Esnaq80MyNZIYJXyAKGAgwPE3ROQKwgiaMHuLCib9aU6ZKrOlCDPBFpRTWVTwibwQ\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"1080\" height=\"541.9500732421875\" style=\"outline: 0px;visibility: visible !important;width: 538.797px !important;\" width=\"538.7999877929688\" \/><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/section>\n<section style=\"outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 10pt;line-height: 20px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u56fe2 \u5e94\u7b54\u8005\u548c\u975e\u5e94\u7b54\u8005\u5de8\u566c\u7ec6\u80de\u4e9a\u7fa4\u7684 M.Sig.Score \u4e0d\u540c<\/span><\/section>\n<p style=\"outline: 0px;text-align: left;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">3\u3001APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+\u8017\u7aedT\uff08Tex\uff09\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/span>    <o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<p style=\"outline: 0px;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u901a\u8fc7\u5728\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u60a3\u8005\u4e2d\u8fdb\u884c\u7ec6\u80de\u95f4\u901a\u4fe1\uff08Cell-Cell Interaction, CCI\uff09\u5206\u6790\uff0c\u7814\u7a76\u8005\u53d1\u73b0<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ T\u7ec6\u80de\u4e4b\u95f4\u5b58\u5728\u5927\u91cf\u7684\u7ec6\u80de\u95f4\u901a\u4fe1\uff0c\u5c24\u5176\u662f\u5728\u975e\u54cd\u5e94\u8005\u4e2d\uff0cCD8+ T\u7ec6\u80de\u663e\u793a\u51fa\u589e\u52a0\u7684\u5165\u7ad9\u901a\u4fe1\u5f3a\u5ea6\uff0c\u800cAPOE+\u5de8\u566c\u7ec6\u80de\u5219\u663e\u793a\u51fa\u589e\u52a0\u7684\u51fa\u7ad9\u901a\u4fe1\u5f3a\u5ea6<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u3002\u8fdb\u4e00\u6b65\u7684\u5206\u6790\u63ed\u793a\u4e86APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ Tex\u7ec6\u80de\u4e4b\u95f4\u7684\u7279\u5b9a\u901a\u4fe1\u6a21\u5f0f\uff0c\u5176\u4e2dAPOE+\u5de8\u566c\u7ec6\u80de\u4e0a\u7684MIF\uff08CD74+CXCR4\uff09\u53d7\u4f53\u7684\u901a\u4fe1\u4f5c\u7528\u5c24\u4e3a\u663e\u8457\uff0c\u53ef\u80fd\u901a\u8fc7\u514d\u75ab\u6291\u5236\u4f5c\u7528\u5f71\u54cdICI\u7684\u7597\u6548\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8005\u5229\u7528\u6765\u81ea\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\uff08TCGA\uff09\u548c\u57fa\u56e0\u8868\u8fbe\u7efc\u5408\u6570\u636e\u5e93\uff08GEO\uff09\u7684TNBC\u8f6c\u5f55\u6570\u636e\uff0c\u8ba1\u7b97\u4e86\u76f8\u5e94\u7684Exhausted.score\u548cAPOE.score\uff0c\u5e76\u53d1\u73b0\u4e24\u8005\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u7684\u6b63\u76f8\u5173\u6027\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ Tex\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u53ef\u80fd\u662f\u5bfc\u81f4TNBC\u60a3\u8005ICI\u6cbb\u7597\u5931\u8d25\u7684\u5173\u952e\u56e0\u7d20\u4e4b\u4e00<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u3002<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<section style=\"margin-bottom: 8px;outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018371\" data-ratio=\"1.1953703703703704\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_yiau0hI0meRefzAq3KbQdDxKmQI6ZQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6tIZjBOyAQllI5Esnaq80MicQy5ADjFSjdgwnCiaMgibib9Y4m6yiau0hI0meRefzAq3KbQdDxKmQI6ZQ\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"1080\" height=\"651.090087890625\" style=\"outline: 0px;visibility: visible !important;width: 544.688px !important;\" width=\"544.7000122070312\" \/><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/section>\n<p style=\"outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 10pt;line-height: 20px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u56fe3 APOE+\u5de8\u566c\u7ec6\u80de\u4e0e CD8+ Tex \u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5f71\u54cd TNBC \u7684 ICI \u53cd\u5e94<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/p>\n<p style=\"outline: 0px;text-align: left;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">4\u3001APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+\u8017\u7aedT\uff08Tex\uff09\u7ec6\u80de\u4e4b\u95f4\u7684\u7a7a\u95f4\u8ddd\u79bb\u5bf9ICI\u6cbb\u7597\u53cd\u5e94\u7684\u5f71\u54cd<\/span><\/p>\n<p style=\"outline: 0px;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u7814\u7a76\u8005\u9009\u53d6\u4e86\u63a5\u53d7ICI\u6cbb\u7597\u7684\u54cd\u5e94\u8005\u548c\u672a\u7ecf\u6cbb\u7597\u7684\u60a3\u8005\u6837\u672c\uff0c\u901a\u8fc7mIHC\u6280\u672f\u89c2\u5bdf\u5230\u5728\u54cd\u5e94\u8005\u4e2d\uff0cAPOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ Tex\u7ec6\u80de\u4e4b\u95f4\u7684\u8ddd\u79bb\u8f83\u957f\uff0c\u800c\u5728\u672a\u7ecf\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u8fd9\u4e9b\u7ec6\u80de\u7684\u8ddd\u79bb\u8f83\u77ed\u3002\u901a\u8fc7\u7a7a\u95f4\u5206\u6790\uff0c\u7814\u7a76\u8005\u6d4b\u91cf\u4e86CD8+ Tex\u7ec6\u80de\u548cCD8+\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u5230APOE+\u5de8\u566c\u7ec6\u80de\u7684\u6700\u8fd1\u8ddd\u79bb\uff0c\u53d1\u73b0<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u5728\u54cd\u5e94\u8005\u4e2d\u5927\u591a\u6570CD8+ Tex\u7ec6\u80de\u4f4d\u4e8eAPOE+\u5de8\u566c\u7ec6\u80de200\u5fae\u7c73\u4ee5\u5916\uff0c\u800c\u5728\u672a\u7ecf\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0cCD8+ Tex\u7ec6\u80de\u6570\u91cf\u66f4\u591a\u4e14\u66f4\u63a5\u8fd1APOE+\u5de8\u566c\u7ec6\u80de<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u3002\u76f8\u53cd\uff0cCD8+\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u4e0eAPOE+\u5de8\u566c\u7ec6\u80de\u7684\u8ddd\u79bb\u5728\u54cd\u5e94\u8005\u4e2d\u8f83\u77ed\u3002<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<p style=\"outline: 0px;text-align: left;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">5\u3001APOE\u6291\u5236\u5242\u4e0eICI\u6cbb\u7597\u7684\u8054\u5408\u4f7f\u7528\u663e\u793a\u51fa\u6700\u4f73\u7684\u6cbb\u7597\u6548\u679c<\/span><\/p>\n<p style=\"outline: 0px;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u901a\u8fc7\u5efa\u7acb4T1\u8377\u7624\u5c0f\u9f20\u6a21\u578b\uff0c\u7814\u7a76\u8005\u5c06\u5c0f\u9f20\u968f\u673a\u5206\u4e3a\u56db\u7ec4\uff1a\u5bf9\u7167\u7ec4\uff08G1\uff09\u3001APOE\u6291\u5236\u5242\uff08COG 133 TFA\uff09\u6cbb\u7597\u7ec4\uff08G2\uff09\u3001\u6297PD-1\u6cbb\u7597\u7ec4\uff08G3\uff09\u4ee5\u53caAPOE\u6291\u5236\u5242\u548c\u6297PD-1\u8054\u5408\u6cbb\u7597\u7ec4\uff08G4\uff09\u3002\u5b9e\u9a8c\u8fc7\u7a0b\u4e2d\uff0c\u4ece\u7b2c8\u5929\u5f00\u59cb\uff0c\u901a\u8fc7\u4f53\u5185\u6210\u50cf\u6280\u672f\u89c2\u5bdf\u5404\u7ec4\u5c0f\u9f20\u80bf\u7624\u5927\u5c0f\u7684\u53d8\u5316\u3002\u7ed3\u679c\u663e\u793a\uff0c<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u8054\u5408\u6cbb\u7597\u7ec4\uff08G4\uff09\u5728\u80bf\u7624\u6291\u5236\u6548\u679c\u4e0a\u8868\u73b0\u6700\u4f73\uff0c\u4e0e\u80bf\u7624\u57fa\u7ebf\u76f8\u6bd4\uff0c\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u5dee\u5f02<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u3002\u6b64\u5916\uff0c\u901a\u8fc7Hematoxylin-eosin\uff08H&E\uff09\u67d3\u8272\u3001ki67\u514d\u75ab\u7ec4\u5316\uff08IHC\uff09\u67d3\u8272\u548c\u591a\u91cd\u514d\u75ab\u7ec4\u5316\uff08mIHC\uff09\u67d3\u8272\u5bf9\u5c0f\u9f20\u80bf\u7624\u6807\u672c\u8fdb\u884c\u4e86\u8fdb\u4e00\u6b65\u5206\u6790\u3002H&E\u67d3\u8272\u786e\u8ba4\u4e86\u80bf\u7624\u7ec4\u7ec7\u7684\u5b58\u5728\uff0c\u800cki67\u9633\u6027\u7387\u5728\u8054\u5408\u6cbb\u7597\u7ec4\u4e2d\u6700\u4f4e\uff0c\u8868\u660e\u8be5\u7ec4\u7684\u80bf\u7624\u589e\u6b96\u6f5c\u529b\u53d7\u5230\u6291\u5236\u3002mIHC\u67d3\u8272\u7ed3\u679c\u8868\u660e\uff0c<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u5728\u8054\u5408\u6cbb\u7597\u7ec4\u4e2d\uff0cAPOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ Tex\u7ec6\u80de\u8ddd\u79bb\u4e0d\u8d85\u8fc7100\u5fae\u7c73\u7684\u7ec6\u80de\u6570\u91cf\u663e\u8457\u4f4e\u4e8e\u5176\u4ed6\u7ec4\uff0c\u8fd9\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86APOE\u6291\u5236\u5242\u80fd\u591f\u901a\u8fc7\u5e72\u6270APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+ Tex\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u6765\u589e\u5f3aICI\u6cbb\u7597\u7684\u6548\u679c<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u3002<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<section style=\"margin-bottom: 8px;outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018368\" data-ratio=\"1.2472222222222222\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_ytb7QoPUiagribP3qkK4lIFYsz4tUw.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx6tIZjBOyAQllI5Esnaq80M3A7NSAjJpT5fCzOwiaTa80d207vytb7QoPUiagribP3qkK4lIFYsz4tUw\/640?wx_fmt=jpeg&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"jpeg\" data-w=\"1080\" height=\"735.3599853515625\" style=\"outline: 0px;visibility: visible !important;width: 589.578px !important;\" width=\"589.5800170898438\" \/><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/section>\n<p style=\"outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 10pt;line-height: 20px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u56fe4 adapalene\u5bf9PCa\u7ec6\u80de\u4e2dRA\u4fe1\u53f7\u548c\u4ee3\u8c22\u9014\u5f84\u7684\u5f71\u54cd<\/span><\/p>\n<p style=\"outline: 0px;text-align: left;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">6\u3001\u9a8c\u8bc1M.Sig\u6a21\u578b\u7684\u6cdb\u764c\u9002\u7528\u6027<\/span><\/p>\n<p style=\"outline: 0px;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u5728\u9a8c\u8bc1M.Sig\u6a21\u578b\u7684\u6cdb\u764c\u9002\u7528\u6027\u65b9\u9762\uff0c\u7814\u7a76\u8005\u91c7\u7528\u4e86\u771f\u5b9e\u4e16\u754c\u7684\u514d\u75ab\u6cbb\u7597\u6570\u636e\u8fdb\u884c\u5206\u6790\u3002\u4ed6\u4eec\u5229\u7528\u4e86\u6765\u81ea\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u7684\u6570\u636e\u96c6\uff0c\u901a\u8fc7\u5355\u6837\u672c\u57fa\u56e0\u96c6\u5bcc\u96c6\u5206\u6790\uff08ssGSEA\uff09\u7b97\u6cd5\u6765\u8bc4\u4f30\u6bcf\u4e2a\u57fa\u56e0\u5728M.Sig\u6a21\u578b\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u5e76\u636e\u6b64\u8ba1\u7b97\u4e86M.Sig\u5f97\u5206\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5141\u8bb8\u7814\u7a76\u8005\u4eec\u8bc4\u4f30\u4e2a\u4f53\u60a3\u8005\u5bf9ICI\u6cbb\u7597\u7684\u53ef\u80fd\u53cd\u5e94\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">M.Sig\u6a21\u578b\u5728\u591a\u4e2a\u764c\u75c7\u961f\u5217\u4e2d\u5c55\u73b0\u51fa\u4e86\u8f83\u9ad8\u7684\u51c6\u786e\u6027\uff0c\u80fd\u591f\u6709\u6548\u9884\u6d4b\u60a3\u8005\u5bf9ICI\u6cbb\u7597\u7684\u53cd\u5e94<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u3002<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<section style=\"margin-bottom: 8px;outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018369\" data-ratio=\"1.275\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_GBAQl0jhdk5Fibq8S3cd22osXfLy7Q.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6tIZjBOyAQllI5Esnaq80Mb4zk4nibqKTIm8770icGF250urpGBAQl0jhdk5Fibq8S3cd22osXfLy7Q\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"1080\" height=\"711.6799926757812\" style=\"outline: 0px;visibility: visible !important;width: 558.156px !important;\" width=\"558.1599731445312\" \/><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/section>\n<p style=\"outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 10pt;line-height: 20px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u56fe5 \u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u4e2d\u514d\u75ab\u7ec6\u80de\u666f\u89c2\u7684UMAP\u56fe<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<p style=\"outline: 0px;text-align: center;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;color: rgb(0, 82, 255);\">\u6587\u7ae0\u5c0f\u7ed3<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\"><\/span><\/p>\n<p style=\"outline: 0px;line-height: 25.5px;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u672c\u7814\u7a76\u901a\u8fc7\u6574\u5408\u5355\u7ec6\u80deRNA\u6d4b\u5e8f(scRNA-seq)\u548c\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\uff0c\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u7684M.Sig\u6a21\u578b\uff0c\u8be5\u6a21\u578b\u80fd\u591f\u6709\u6548\u9884\u6d4b\u6cdb\u764c\u60a3\u8005\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242(ICI)\u6cbb\u7597\u7684\u53cd\u5e94\u548c\u9884\u540e\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u4e09\u9634\u6027\u4e73\u817a\u764c(TNBC)\u4e2d\uff0c\u975e\u54cd\u5e94\u8005\u4f53\u5185APOE+\u5de8\u566c\u7ec6\u80de\u7684\u6bd4\u4f8b\u663e\u8457\u9ad8\u4e8e\u54cd\u5e94\u8005\uff0c\u4e14APOE+\u5de8\u566c\u7ec6\u80de\u4e0eCD8+\u8017\u7aedT(Tex)\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u53ca\u7a7a\u95f4\u8ddd\u79bb\u4e0eICI\u6cbb\u7597\u53cd\u5e94\u5bc6\u5207\u76f8\u5173\u3002\u6b64\u5916\uff0cAPOE\u6291\u5236\u5242\u4e0eICI\u7684\u8054\u5408\u4f7f\u7528\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u6700\u4f73\u7684\u6cbb\u7597\u6548\u679c\u3002\u8fd9\u4e9b\u53d1\u73b0\u63ed\u793a\u4e86APOE+\u5de8\u566c\u7ec6\u80de\u5728\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u5e76\u4e3a\u63d0\u9ad8ICI\u6cbb\u7597\u6548\u679c\u63d0\u4f9b\u4e86\u6f5c\u5728\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(255, 0, 0);font-weight: bold;\">\u5bf9\u673a\u5668\u5b66\u4e60\u611f\u5174\u8da3\u7684\u5b9d\u5b50\u4e00\u5b9a\u4e0d\u8981\u9519\u8fc7\u6211\u4eec\u7684\u81ea\u5b66\u8bfe\u7a0b\u54e6~<\/span><\/p>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018373\" data-ratio=\"1\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_B2jkicacLzPjw4xMSqVvoucZjonVDA-18.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-wrap: wrap;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018374\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"http:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_7TvAyUibd1TPhJmZfialJtv6tu2SEg-26.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><br \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature 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