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10px;margin-bottom: -14px;transform: translate3d(13px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;background-color: rgb(255, 255, 255);padding-right: 15px;padding-left: 13px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;background-color: rgb(206, 233, 255);min-width: 5%;height: auto;padding: 5px 22px;\">\n<section style=\"text-align: justify;font-size: 18px;color: rgb(62, 62, 62);letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u539f\u7406\uff1a<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;min-width: 5%;flex: 0 0 auto;height: auto;\">\n<section style=\"transform: perspective(0px);transform-style: flat;\" powered-by=\"xiumi.us\">\n<section style=\"transform: translate3d(5px, 0px, 0px) rotateX(180deg);\">\n<section style=\"display: inline-block;width: 6px;height: 6px;vertical-align: top;overflow: hidden;border-radius: 460px;background-color: rgb(244, 171, 189);\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 3px;border-color: rgb(244, 171, 189);padding: 18px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;line-height: 1.8;letter-spacing: 1.5px;\">\n<p style=\"white-space: normal;\">ldscr\u7684\u76ee\u6807\u662f\u5229\u7528r\u4e2d\u7684LD\u8bc4\u5206\u56de\u5f52\uff0c\u4eceGWAS\u6c47\u603b\u7edf\u8ba1\u91cf\u4e2d\u4f30\u7b97\u9057\u4f20\u5ea6\u548c\u8de8\u6027\u72b6\u9057\u4f20\u76f8\u5173\u6027\u3002LD\u8bc4\u5206\u56de\u5f52\u7528\u4e8e\u4f30\u7b97\u9057\u4f20\u5ea6\u548c\u9057\u4f20\u76f8\u5173\u6027\u7684\u7ec6\u8282\u5df2\u7ecf\u53d1\u8868\u3002\u8be5\u5305\u6539\u7f16\u4e86\u6700\u521d\u5728 GenomicSEM\u4e2d\u5b9e\u73b0\u7684\u4ee3\u7801\u548c\u529f\u80fd\u3002<br \/><\/p>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">install.packages(<span class=\"code-snippet__string\">\"devtools\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">devtools::install_github(<span class=\"code-snippet__string\">\"mglev1n\/ldscr\"<\/span>)#\u6700\u65b0\u7248\u672c\u7684R\u65e0\u6cd5\u5b89\u88c5\u6210\u679c\uff0c\u5efa\u8bae\u7528R <span class=\"code-snippet__number\">4.1<\/span><span class=\"code-snippet__number\">.1<\/span>\u7248\u7684\u8fdb\u884c\u5b89\u88c5<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: -14px;transform: translate3d(13px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;background-color: rgb(255, 255, 255);padding-right: 15px;padding-left: 13px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;background-color: rgb(206, 233, 255);min-width: 5%;height: auto;padding: 5px 22px;\">\n<section style=\"text-align: justify;font-size: 18px;color: rgb(62, 62, 62);letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u6570\u636e\u4ecb\u7ecd<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;min-width: 5%;flex: 0 0 auto;height: auto;\">\n<section style=\"transform: perspective(0px);transform-style: flat;\" powered-by=\"xiumi.us\">\n<section style=\"transform: translate3d(5px, 0px, 0px) rotateX(180deg);\">\n<section style=\"display: inline-block;width: 6px;height: 6px;vertical-align: top;overflow: hidden;border-radius: 460px;background-color: rgb(244, 171, 189);\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 3px;border-color: rgb(244, 171, 189);padding: 18px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;line-height: 1.8;letter-spacing: 1.5px;\">\n<p style=\"white-space: normal;\">ldsc_h2()\u53ef\u4ee5\u7528\u6765\u4f30\u8ba1\u9057\u4f20\u3002<\/p>\n<p style=\"white-space: normal;\">\u63d0\u4f9b\u4e86\u793a\u4f8bGWAS\u6570\u636esumstats_munged_example()\u3002\u5927\u5bb6\u53ef\u4ee5\u5229\u7528\u5185\u7f6e\u7684LD\u53c2\u8003\u6570\u636e\u8fdb\u884c\u6f14\u7ec3\uff0c\u4e5f\u53ef\u63d0\u4f9b\u81ea\u5df1\u7684\u6570\u636e\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u6570\u636e\u6587\u4ef6\u50a8\u5b58\u5728R\u5305library\u4e2dldscr\u5305\u7684extdata\u6587\u4ef6\u5939\u91cc<\/p>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.20353982300884957\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_IF1EA41BvzbQ2yoicdoQJP9IpibPxg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QtP2KYQDSKM5aGmnm1vwEuff7VHJvnFJaBWm6NSbN9soSPcN8IF1EA41BvzbQ2yoicdoQJP9IpibPxg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"226\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">#\u52a0\u8f7dldscr<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__title\">library<\/span><span class=\"code-snippet__params\">(ldscr)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__title\">setwd<\/span><span class=\"code-snippet__params\">(<span class=\"code-snippet__string\">\"D:\/R\/R-4.1.1\/library\/ldscr\"<\/span>)<\/span>#\u6839\u636e\u81ea\u5df1\u7684\u6587\u4ef6\u4f4d\u7f6e\u8fdb\u884c\u66f4\u6539<\/span><\/code><code><span class=\"code-snippet_outer\">df <- <span class=\"code-snippet__title\">sumstats_munged_example<\/span><span class=\"code-snippet__params\">(example = <span class=\"code-snippet__string\">\"BMI\"<\/span>)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">h2_res <- <span class=\"code-snippet__title\">ldsc_h2<\/span><span class=\"code-snippet__params\">(munged_sumstats = df, ancestry = <span class=\"code-snippet__string\">\"EUR\"<\/span>)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">ldsc_rg\u53ef\u7528\u4e8e\u4f30\u8ba1\u4e24\u4e2a\u6216\u591a\u4e2a\u6027\u72b6\u4e4b\u95f4\u7684\u4ea4\u53c9\u6027\u72b6\u9057\u4f20\u76f8\u5173\u6027<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">rg_res <- <span class=\"code-snippet__title\">ldsc_rg<\/span><span class=\"code-snippet__params\">(<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> munged_sumstats = <span class=\"code-snippet__built_in\">list<\/span>(<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"APOB\"<\/span> = sumstats_munged_example(example = <span class=\"code-snippet__string\">\"APOB\"<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"LDL\"<\/span> = sumstats_munged_example(example = <span class=\"code-snippet__string\">\"LDL\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"> ),<\/span><\/code><code><span class=\"code-snippet_outer\"> ancestry = <span class=\"code-snippet__string\">\"EUR\"<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.2915129151291513\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_XPbw87y1UiaiaOVweK30O4j04ZF60Q.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QtP2KYQDSKM5aGmnm1vwEufn9wZWRcm8yZZo2Gb1lFJHapt5MXPbw87y1UiaiaOVweK30O4j04ZF60Q\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"813\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">rg_res#\u67e5\u770b\u8ba1\u7b97\u7ed3\u679c<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.45\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_5bKugqpsMgcQ5hbiaKHpib8uTHyQOA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QtP2KYQDSKM5aGmnm1vwEuficrBjf3qe4bXTJAfpJbcoUqvVTB5bKugqpsMgcQ5hbiaKHpib8uTHyQOA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"800\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section style=\"text-align: justify;line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u53ef\u89c1\u76f8\u5173\u6027\uff1arg=0.936<\/p>\n<p style=\"white-space: normal;\">\u663e\u8457\u6027P\u503crg_pval=5.88e-20<\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5927\u591a\u6570\u60c5\u51b5\u6211\u4eec\u90fd\u9700\u8981\u6839\u636e\u81ea\u5df1\u5206\u6790\u7684\u6570\u636e\u8fdb\u884c\u9057\u4f20\u76f8\u5173\u6027\u7684\u8ba1\u7b97\uff0c\u8fd9\u65f6\u5c31\u9700\u8981\u4e0b\u8f7d\u5e76\u5904\u7406\u539f\u59cb\u6570\u636e\uff0c\u90a3\u4e48\u539f\u59cb\u6570\u636e\u5982\u4f55\u8fdb\u884c\u5904\u7406\u5462<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.8;text-align: justify;letter-spacing: 1.5px;\">\n<p style=\"white-space: normal;\"><strong>\u9996\u5148\u4e0b\u8f7d\u9700\u8981\u5206\u6790\u7684\u6570\u636e<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6469849246231156\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_NOqc4N26yx60u8CQsHMsDee7HgOMLQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QtP2KYQDSKM5aGmnm1vwEufv5iboCHj0lVyyhLWIjYeD6KxxNOqc4N26yx60u8CQsHMsDee7HgOMLQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"796\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.8;text-align: justify;letter-spacing: 1.5px;\">\n<p style=\"white-space: normal;\"><strong>\u7528R\u5305gwasglue\u8fdb\u884c\u6570\u636e\u683c\u5f0f\u5904\u7406<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u8fd9\u4e2aR\u5305\u5145\u5f53\u53ef\u4ee5\u8bfb\u53d6\u6216\u67e5\u8be2GWAS\u6c47\u603b\u6570\u636e\u7684\u5305\u548c\u53ef\u4ee5\u5206\u6790GWAS\u6c47\u603b\u6570\u636e\u7684\u5305\u4e4b\u95f4\u7684\u7ba1\u9053\u3002\u4ee5\u4e0b\u662f\u5b83\u5728GWAS\u6570\u636e\u548c\u5206\u6790\u7684\u603b\u4f53\u751f\u6001\u7cfb\u7edf\u4e2d\u7684\u4f4d\u7f6e:<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7574074074074074\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_xy4r385QicrCHRnIkGIBaw1JDvjMag.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QtP2KYQDSKM5aGmnm1vwEufynp5FyMKgI3mAEnXicObrODvaPxy4r385QicrCHRnIkGIBaw1JDvjMag\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5b8c\u6574\u7684GWAS\u6c47\u603b\u6570\u636e\u96c6\u73b0\u5728\u975e\u5e38\u4e30\u5bcc\u3002\u5728IEU GWAS\u6570\u636e\u5e93\u4e2d\u6709\u4e00\u4e2a\u5927\u578b\u7684\u6570\u636e\u5e93\uff0c\u5305\u542b\u4e86\u7ecf\u8fc7\u7ba1\u7406\u7684\u3001\u534f\u8c03\u7684\u548c\u8d28\u91cf\u63a7\u5236\u7684\u6570\u636e\u96c6\u3002\u4ed6\u4eec\u53ef\u4ee5\u901a\u8fc7API\u76f4\u63a5\u67e5\u8be2,\u6216\u8005\u901a\u8fc7ieugwasr R\u5305,\u6216ieugwaspy python\u5305\u3002\u4f46\u662f\uff0c\u5bf9\u4e8e\u53ef\u4ee5\u5728HPC\u73af\u5883\u4e2d\u4f7f\u7528\u7684\u66f4\u5feb\u7684\u67e5\u8be2\uff0c\u76f4\u63a5\u8bbf\u95ee\u6570\u636e\u800c\u4e0d\u662f\u901a\u8fc7\u4e91\u7cfb\u7edf\u662f\u6709\u5229\u7684\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u4e8e\u662f\uff0c\u5f00\u53d1\u4e86\u4e00\u79cd\u7528\u4e8e\u5b58\u50a8\u548c\u534f\u8c03GWAS\u6c47\u603b\u6570\u636e\u7684\u683c\u5f0f\uff0c\u79f0\u4e3aGWAS VCF\u683c\u5f0f\uff0c\u53ef\u4ee5\u4f7f\u7528gwas2vcf\u521b\u5efa\u3002IEU GWAS\u6570\u636e\u5e93\u4e2d\u7684\u6240\u6709\u6570\u636e\u5747\u53ef\u4ee5\u8fd9\u79cd\u683c\u5f0f\u4e0b\u8f7d\u3002\u8fd9\u4e2aR\u5305\u63d0\u4f9b\u4e86\u5feb\u901f\u4fbf\u6377\u7684\u67e5\u8be2\u548c\u521b\u5efaGWAS VCF\u683c\u5f0f\u7684GWAS\u6c47\u603b\u6570\u636e\u7684\u529f\u80fd\u3002<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">#\u5b89\u88c5\u5904\u7406VCF\u683c\u5f0f\u7684R\u5305<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__keyword\">if<\/span> (!require(<span class=\"code-snippet__string\">\"BiocManager\"<\/span>, quietly = TRUE))<\/span><\/code><code><span class=\"code-snippet_outer\"> install.packages(<span class=\"code-snippet__string\">\"BiocManager\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">BiocManager::install(<span class=\"code-snippet__string\">\"VariantAnnotation\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">library(VariantAnnotation)<\/span><\/code><code><span class=\"code-snippet_outer\">devtools::install_github(<span class=\"code-snippet__string\">\"mrcieu\/gwasglue\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">#\u52a0\u8f7d<\/span><\/code><code><span class=\"code-snippet_outer\">library(gwasglue)<\/span><\/code><code><span class=\"code-snippet_outer\">library(TwoSampleMR)<\/span><\/code><code><span class=\"code-snippet_outer\">setwd(<span class=\"code-snippet__string\">\"D:\/R\/R-4.1.1\/library\/ldscr\"<\/span>)#\u6839\u636e\u81ea\u5df1\u6587\u4ef6\u60c5\u51b5\u8bbe\u7f6e\u8def\u5f84<\/span><\/code><code><span class=\"code-snippet_outer\">dat<- readVcf(<span class=\"code-snippet__string\">\"ukb-b-956.vcf.gz\"<\/span>) #\u8bfb\u5165GWAS\u7684summary\u7ed3\u5c40\/\u66b4\u9732\u6570\u636e\u7684VCF\u683c\u5f0f\u6587\u4ef6<\/span><\/code><code><span class=\"code-snippet_outer\">dat <-gwasvcf_to_TwoSampleMR(dat)#\u8f6c\u6362\u4e3aTwoSampleMR\u53ef\u4ee5\u8bc6\u522b\u7684\u683c\u5f0f<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5c0f\u56fe\u6e29\u99a8\u63d0\u793a\uff1a\u7531\u4e8eGWAS\u7684summary\u6570\u636e\u6587\u4ef6\u5927\u5c0f\u518d200-300MB\u5de6\u53f3\uff0c\u6240\u4ee5windows\u4e0b\u7684R\u53ef\u80fd\u8bfb\u53d6\u5931\u8d25\uff0c\u5efa\u8bae\u5728linux\u4e0b\u8fdb\u884c\u683c\u5f0f\u8f6c\u6362\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">dat\u6570\u636e\u6846\u7b2c3,4,5,6,9,11\u5217\uff1b\u8fd9\u91cc\u5206\u522b\u5bf9\u5e94\u7684\u662f”A2″,”A1″,”beta”,”se”,”N”,”SNP”<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">dat<- dat [, c(<span class=\"code-snippet__number\">3<\/span>:<span class=\"code-snippet__number\">6<\/span>,<span class=\"code-snippet__number\">9<\/span>,<span class=\"code-snippet__number\">11<\/span>)]<\/span><\/code><code><span class=\"code-snippet_outer\">colnames(dat)<-c(<span class=\"code-snippet__string\">\"A2\"<\/span>,<span class=\"code-snippet__string\">\"A1\"<\/span>,<span class=\"code-snippet__string\">\"beta\"<\/span>,<span class=\"code-snippet__string\">\"se\"<\/span>,<span class=\"code-snippet__string\">\"N\"<\/span>,<span class=\"code-snippet__string\">\"SNP\"<\/span>)#\u5bf9\u6570\u636e\u6587\u4ef6\u91cd\u547d\u540d<\/span><\/code><code><span class=\"code-snippet_outer\">#\u6700\u540e\u5c06\u6587\u4ef6\u4fdd\u5b58\u4e3atxt.gz\u683c\u5f0f<\/span><\/code><code><span class=\"code-snippet_outer\">write.table(dat, gzfile(<span class=\"code-snippet__string\">\"ukb-b-7178-sumstats-munged.txt.gz\"<\/span>), <\/span><\/code><code><span class=\"code-snippet_outer\"> sep = <span class=\"code-snippet__string\">\"t\"<\/span>, row.names = FALSE)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u6570\u636e\u683c\u5f0f\u5904\u7406\u6210\u529f\u5373\u53ef\u6309\u7167\u4e0a\u8ff0\u6d41\u7a0b\u4f30\u7b97\u9057\u4f20\u5ea6\u548c\u9057\u4f20\u76f8\u5173\u6027<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u5173\u4e8eGWAS summary \u6570\u636e\u9057\u4f20\u5ea6\u548c\u9057\u4f20\u76f8\u5173\u6027\u4f30\u7b97\u5c0f\u56fe\u5c31\u4ecb\u7ecd\u5b8c\u6bd5\u4e86\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u7262\u8bb0\u5404\u4e2a\u6587\u4ef6\u7684\u7ed3\u6784\u4fe1\u606f\uff0c\u8fd9\u5728\u540e\u7eed\u7684\u6570\u636e\u5206\u6790\u4e2d\u975e\u5e38\u91cd\u8981\u3002<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;border-color: rgb(176, 176, 176);padding: 7px;\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: rgba(249, 238, 237, 0.5);padding: 18px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;font-size: 14px;letter-spacing: 2px;line-height: 1.8;\">\n<p style=\"white-space: normal;\">\u6b22\u8fce\u4f7f\u7528\uff1a\u4e91\u751f\u4fe1\u751f\u7269\u4fe1\u606f\u5b66\u5e73\u53f0\uff08 http:\/\/www.biocloudservice.com\/home.html\uff09\uff0c\u4e86\u89e3\u66f4\u591a\u751f\u4fe1\u77e5\u8bc6\u4e0e\u6280\u5de7\u5206\u6790\u3002<\/p>\n<p style=\"white-space: normal;\">\u8bf7\u671f\u5f85\u5c0f\u56fe\u7684\u4e0b\u4e00\u671f\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u77e5\u8bc6\u5206\u4eab\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<\/section>\n<section style=\"text-align: justify;font-size: 14px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u6b22\u8fce\u4f7f\u7528\uff1a\u4e91\u751f\u4fe1\u5e73\u53f0 ( http:\/\/www.biocloudservice.com\/home.html)<\/p>\n<\/section>\n<section style=\"transform: scale(0.5);transform-origin: center center;margin-top: -65px;margin-bottom: -65px;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_yibFsicLO4HWo2JC2zqQFibb8ecSdQ.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/2wJ7bWfS0QtP2KYQDSKM5aGmnm1vwEufxlWUvOOiciaBzW6blF8RicdMzBw8EGyibFsicLO4HWo2JC2zqQFibb8ecSdQ\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"258\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:26.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:26.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;background-color: rgb(249, 174, 165);padding: 10px 0px;\" width=\"96.3700%\">\n<section style=\"line-height: 1;text-align: center;font-size: 17px;color: rgb(255, 255, 255);letter-spacing: 5px;\" powered-by=\"xiumi.us\">\n<p><strong>\u5f80\u671f\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:26.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:26.classicTable1:1.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<section style=\"font-size: 14px;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247485058&idx=1&sn=01e2ab90b374e9a97c88722233b0036f&chksm=c1b17b7ff6c6f269d29dc41ef67408d077cd202ba1262833fa98df4ca178d7fc302b1158a7f4&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u56fe\u5b66umap\u56fe-\u5229\u7528ggplot2\u5b9a\u5236\u81ea\u5df1\u7406\u60f3\u7684umap\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u56fe\u5b66umap\u56fe-\u5229\u7528ggplot2\u5b9a\u5236\u81ea\u5df1\u7406\u60f3\u7684umap\u56fe\uff01\uff01<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:26.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:26.classicTable1:2.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<section style=\"font-size: 14px;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247485041&idx=1&sn=89eaefdfef4673d70641bd46f874e28f&chksm=c1b17b8cf6c6f29a28a17e43cb872c3c5fe32044e2058b6aa488b0880b86fe8dc6c1abdc9c0b&scene=21#wechat_redirect\" textvalue=\"\u4fdd\u59c6\u7ea7\u6559\u7a0b-\u5c0f\u56fe\u6559\u4f60\u5982\u4f55\u4f7f\u7528ggrisk\u9ad8\u6548\u7684\u7ed8\u5236\u98ce\u9669\u56e0\u5b50\u8054\u52a8\u56fe\uff01\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u4fdd\u59c6\u7ea7\u6559\u7a0b-\u5c0f\u56fe\u6559\u4f60\u5982\u4f55\u4f7f\u7528ggrisk\u9ad8\u6548\u7684\u7ed8\u5236\u98ce\u9669\u56e0\u5b50\u8054\u52a8\u56fe\uff01\uff01\uff01<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:26.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:26.classicTable1:3.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<section style=\"font-size: 14px;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247485026&idx=1&sn=ab42053deabf774b59be8627812bb600&chksm=c1b17b9ff6c6f289d6c01ddc21b4a94241116879fc3ca9b33ca033cebfde972debf2c7f2de6d&scene=21#wechat_redirect\" textvalue=\"\u4e09\u5206\u949f\u5b66\u4f1a\u7528ggridges\u753b\u5cf0\u5ce6\u56fe\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u4e09\u5206\u949f\u5b66\u4f1a\u7528ggridges\u753b\u5cf0\u5ce6\u56fe<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\ud83d\udc47\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8fdb\u5165\u7f51\u5740<\/p>\n<\/section>\n<p style=\"display: none;margin-bottom: 24px;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<div class=\"msg_source_url\"><a href=\"http:\/\/www.biocloudservice.com\/home.html\" target=\"_blank\" rel=\"noopener\">\u9605\u8bfb\u539f\u6587<\/a><\/div>\n<p><\/content><\/p>\n<div class=\"msg_source_url\"><a href=\"http:\/\/www.biocloudservice.com\/home.html\" target=\"_blank\" rel=\"noopener\">\u9605\u8bfb\u539f\u6587<\/a><\/div>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u542c\u8bf4\u53ef\u4ee5\u7528R\u8bed\u8a00\u5b8c\u6210\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u9057\u4f20\u76f8\u5173\uff0c\u4f60\u6765\u4e0d\u6765\u5b66\uff1f \u5c0f\u56fe \u751f\u4fe1\u679c &nbs […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/55979"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=55979"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/55979\/revisions"}],"predecessor-version":[{"id":55987,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/55979\/revisions\/55987"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=55979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=55979"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=55979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

{"id":55979,"date":"2024-06-16T17:22:44","date_gmt":"2024-06-16T09:22:44","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=55979"},"modified":"2024-06-16T17:22:44","modified_gmt":"2024-06-16T09:22:44","slug":"%e5%90%ac%e8%af%b4%e5%8f%af%e4%bb%a5%e7%94%a8r%e8%af%ad%e8%a8%80%e5%ae%8c%e6%88%90%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96%e9%81%97%e4%bc%a0%e7%9b%b8%e5%85%b3%ef%bc%8c%e4%bd%a0%e6%9d%a5","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=55979","title":{"rendered":"\u542c\u8bf4\u53ef\u4ee5\u7528R\u8bed\u8a00\u5b8c\u6210\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u9057\u4f20\u76f8\u5173\uff0c\u4f60\u6765\u4e0d\u6765\u5b66\uff1f"},"content":{"rendered":"

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style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;min-width: 5%;flex: 0 0 auto;height: auto;\">\n<section style=\"transform: perspective(0px);transform-style: flat;\" powered-by=\"xiumi.us\">\n<section style=\"transform: translate3d(5px, 0px, 0px) rotateX(180deg);\">\n<section style=\"display: inline-block;width: 6px;height: 6px;vertical-align: top;overflow: hidden;border-radius: 460px;background-color: rgb(244, 171, 189);\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 3px;border-color: rgb(244, 171, 189);padding: 18px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;line-height: 1.8;letter-spacing: 1.5px;\">\n<p style=\"white-space: normal;\">ldscr\u7684\u76ee\u6807\u662f\u5229\u7528r\u4e2d\u7684LD\u8bc4\u5206\u56de\u5f52\uff0c\u4eceGWAS\u6c47\u603b\u7edf\u8ba1\u91cf\u4e2d\u4f30\u7b97\u9057\u4f20\u5ea6\u548c\u8de8\u6027\u72b6\u9057\u4f20\u76f8\u5173\u6027\u3002LD\u8bc4\u5206\u56de\u5f52\u7528\u4e8e\u4f30\u7b97\u9057\u4f20\u5ea6\u548c\u9057\u4f20\u76f8\u5173\u6027\u7684\u7ec6\u8282\u5df2\u7ecf\u53d1\u8868\u3002\u8be5\u5305\u6539\u7f16\u4e86\u6700\u521d\u5728 GenomicSEM\u4e2d\u5b9e\u73b0\u7684\u4ee3\u7801\u548c\u529f\u80fd\u3002<br \/><\/p>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">install.packages(<span class=\"code-snippet__string\">\"devtools\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">devtools::install_github(<span class=\"code-snippet__string\">\"mglev1n\/ldscr\"<\/span>)#\u6700\u65b0\u7248\u672c\u7684R\u65e0\u6cd5\u5b89\u88c5\u6210\u679c\uff0c\u5efa\u8bae\u7528R <span class=\"code-snippet__number\">4.1<\/span><span class=\"code-snippet__number\">.1<\/span>\u7248\u7684\u8fdb\u884c\u5b89\u88c5<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: -14px;transform: translate3d(13px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;background-color: rgb(255, 255, 255);padding-right: 15px;padding-left: 13px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;background-color: rgb(206, 233, 255);min-width: 5%;height: auto;padding: 5px 22px;\">\n<section style=\"text-align: justify;font-size: 18px;color: rgb(62, 62, 62);letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u6570\u636e\u4ecb\u7ecd<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;min-width: 5%;flex: 0 0 auto;height: auto;\">\n<section style=\"transform: perspective(0px);transform-style: flat;\" powered-by=\"xiumi.us\">\n<section style=\"transform: translate3d(5px, 0px, 0px) rotateX(180deg);\">\n<section style=\"display: inline-block;width: 6px;height: 6px;vertical-align: top;overflow: hidden;border-radius: 460px;background-color: rgb(244, 171, 189);\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 3px;border-color: rgb(244, 171, 189);padding: 18px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;line-height: 1.8;letter-spacing: 1.5px;\">\n<p style=\"white-space: normal;\">ldsc_h2()\u53ef\u4ee5\u7528\u6765\u4f30\u8ba1\u9057\u4f20\u3002<\/p>\n<p style=\"white-space: normal;\">\u63d0\u4f9b\u4e86\u793a\u4f8bGWAS\u6570\u636esumstats_munged_example()\u3002\u5927\u5bb6\u53ef\u4ee5\u5229\u7528\u5185\u7f6e\u7684LD\u53c2\u8003\u6570\u636e\u8fdb\u884c\u6f14\u7ec3\uff0c\u4e5f\u53ef\u63d0\u4f9b\u81ea\u5df1\u7684\u6570\u636e\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u6570\u636e\u6587\u4ef6\u50a8\u5b58\u5728R\u5305library\u4e2dldscr\u5305\u7684extdata\u6587\u4ef6\u5939\u91cc<\/p>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.20353982300884957\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_IF1EA41BvzbQ2yoicdoQJP9IpibPxg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QtP2KYQDSKM5aGmnm1vwEuff7VHJvnFJaBWm6NSbN9soSPcN8IF1EA41BvzbQ2yoicdoQJP9IpibPxg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"226\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">#\u52a0\u8f7dldscr<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__title\">library<\/span><span class=\"code-snippet__params\">(ldscr)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__title\">setwd<\/span><span class=\"code-snippet__params\">(<span class=\"code-snippet__string\">\"D:\/R\/R-4.1.1\/library\/ldscr\"<\/span>)<\/span>#\u6839\u636e\u81ea\u5df1\u7684\u6587\u4ef6\u4f4d\u7f6e\u8fdb\u884c\u66f4\u6539<\/span><\/code><code><span class=\"code-snippet_outer\">df <- <span class=\"code-snippet__title\">sumstats_munged_example<\/span><span class=\"code-snippet__params\">(example = <span class=\"code-snippet__string\">\"BMI\"<\/span>)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">h2_res <- <span class=\"code-snippet__title\">ldsc_h2<\/span><span class=\"code-snippet__params\">(munged_sumstats = df, ancestry = <span class=\"code-snippet__string\">\"EUR\"<\/span>)<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">ldsc_rg\u53ef\u7528\u4e8e\u4f30\u8ba1\u4e24\u4e2a\u6216\u591a\u4e2a\u6027\u72b6\u4e4b\u95f4\u7684\u4ea4\u53c9\u6027\u72b6\u9057\u4f20\u76f8\u5173\u6027<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">rg_res <- <span class=\"code-snippet__title\">ldsc_rg<\/span><span class=\"code-snippet__params\">(<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> munged_sumstats = <span class=\"code-snippet__built_in\">list<\/span>(<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"APOB\"<\/span> = sumstats_munged_example(example = <span class=\"code-snippet__string\">\"APOB\"<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__string\">\"LDL\"<\/span> = sumstats_munged_example(example = <span class=\"code-snippet__string\">\"LDL\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"> ),<\/span><\/code><code><span class=\"code-snippet_outer\"> ancestry = <span class=\"code-snippet__string\">\"EUR\"<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.2915129151291513\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_XPbw87y1UiaiaOVweK30O4j04ZF60Q.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QtP2KYQDSKM5aGmnm1vwEufn9wZWRcm8yZZo2Gb1lFJHapt5MXPbw87y1UiaiaOVweK30O4j04ZF60Q\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"813\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">rg_res#\u67e5\u770b\u8ba1\u7b97\u7ed3\u679c<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.45\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_5bKugqpsMgcQ5hbiaKHpib8uTHyQOA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QtP2KYQDSKM5aGmnm1vwEuficrBjf3qe4bXTJAfpJbcoUqvVTB5bKugqpsMgcQ5hbiaKHpib8uTHyQOA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"800\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section style=\"text-align: justify;line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u53ef\u89c1\u76f8\u5173\u6027\uff1arg=0.936<\/p>\n<p style=\"white-space: normal;\">\u663e\u8457\u6027P\u503crg_pval=5.88e-20<\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5927\u591a\u6570\u60c5\u51b5\u6211\u4eec\u90fd\u9700\u8981\u6839\u636e\u81ea\u5df1\u5206\u6790\u7684\u6570\u636e\u8fdb\u884c\u9057\u4f20\u76f8\u5173\u6027\u7684\u8ba1\u7b97\uff0c\u8fd9\u65f6\u5c31\u9700\u8981\u4e0b\u8f7d\u5e76\u5904\u7406\u539f\u59cb\u6570\u636e\uff0c\u90a3\u4e48\u539f\u59cb\u6570\u636e\u5982\u4f55\u8fdb\u884c\u5904\u7406\u5462<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.8;text-align: justify;letter-spacing: 1.5px;\">\n<p style=\"white-space: normal;\"><strong>\u9996\u5148\u4e0b\u8f7d\u9700\u8981\u5206\u6790\u7684\u6570\u636e<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6469849246231156\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_NOqc4N26yx60u8CQsHMsDee7HgOMLQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QtP2KYQDSKM5aGmnm1vwEufv5iboCHj0lVyyhLWIjYeD6KxxNOqc4N26yx60u8CQsHMsDee7HgOMLQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"796\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"margin: 10px 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;border-left: 5px solid rgb(242, 203, 203);border-bottom-left-radius: 0px;padding-left: 9px;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-start;\">\n<section style=\"margin: 2px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(110, 75, 36);line-height: 1.8;text-align: justify;letter-spacing: 1.5px;\">\n<p style=\"white-space: normal;\"><strong>\u7528R\u5305gwasglue\u8fdb\u884c\u6570\u636e\u683c\u5f0f\u5904\u7406<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u8fd9\u4e2aR\u5305\u5145\u5f53\u53ef\u4ee5\u8bfb\u53d6\u6216\u67e5\u8be2GWAS\u6c47\u603b\u6570\u636e\u7684\u5305\u548c\u53ef\u4ee5\u5206\u6790GWAS\u6c47\u603b\u6570\u636e\u7684\u5305\u4e4b\u95f4\u7684\u7ba1\u9053\u3002\u4ee5\u4e0b\u662f\u5b83\u5728GWAS\u6570\u636e\u548c\u5206\u6790\u7684\u603b\u4f53\u751f\u6001\u7cfb\u7edf\u4e2d\u7684\u4f4d\u7f6e:<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7574074074074074\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_xy4r385QicrCHRnIkGIBaw1JDvjMag.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0QtP2KYQDSKM5aGmnm1vwEufynp5FyMKgI3mAEnXicObrODvaPxy4r385QicrCHRnIkGIBaw1JDvjMag\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5b8c\u6574\u7684GWAS\u6c47\u603b\u6570\u636e\u96c6\u73b0\u5728\u975e\u5e38\u4e30\u5bcc\u3002\u5728IEU GWAS\u6570\u636e\u5e93\u4e2d\u6709\u4e00\u4e2a\u5927\u578b\u7684\u6570\u636e\u5e93\uff0c\u5305\u542b\u4e86\u7ecf\u8fc7\u7ba1\u7406\u7684\u3001\u534f\u8c03\u7684\u548c\u8d28\u91cf\u63a7\u5236\u7684\u6570\u636e\u96c6\u3002\u4ed6\u4eec\u53ef\u4ee5\u901a\u8fc7API\u76f4\u63a5\u67e5\u8be2,\u6216\u8005\u901a\u8fc7ieugwasr R\u5305,\u6216ieugwaspy python\u5305\u3002\u4f46\u662f\uff0c\u5bf9\u4e8e\u53ef\u4ee5\u5728HPC\u73af\u5883\u4e2d\u4f7f\u7528\u7684\u66f4\u5feb\u7684\u67e5\u8be2\uff0c\u76f4\u63a5\u8bbf\u95ee\u6570\u636e\u800c\u4e0d\u662f\u901a\u8fc7\u4e91\u7cfb\u7edf\u662f\u6709\u5229\u7684\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u4e8e\u662f\uff0c\u5f00\u53d1\u4e86\u4e00\u79cd\u7528\u4e8e\u5b58\u50a8\u548c\u534f\u8c03GWAS\u6c47\u603b\u6570\u636e\u7684\u683c\u5f0f\uff0c\u79f0\u4e3aGWAS VCF\u683c\u5f0f\uff0c\u53ef\u4ee5\u4f7f\u7528gwas2vcf\u521b\u5efa\u3002IEU GWAS\u6570\u636e\u5e93\u4e2d\u7684\u6240\u6709\u6570\u636e\u5747\u53ef\u4ee5\u8fd9\u79cd\u683c\u5f0f\u4e0b\u8f7d\u3002\u8fd9\u4e2aR\u5305\u63d0\u4f9b\u4e86\u5feb\u901f\u4fbf\u6377\u7684\u67e5\u8be2\u548c\u521b\u5efaGWAS VCF\u683c\u5f0f\u7684GWAS\u6c47\u603b\u6570\u636e\u7684\u529f\u80fd\u3002<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">#\u5b89\u88c5\u5904\u7406VCF\u683c\u5f0f\u7684R\u5305<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__keyword\">if<\/span> (!require(<span class=\"code-snippet__string\">\"BiocManager\"<\/span>, quietly = TRUE))<\/span><\/code><code><span class=\"code-snippet_outer\"> install.packages(<span class=\"code-snippet__string\">\"BiocManager\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">BiocManager::install(<span class=\"code-snippet__string\">\"VariantAnnotation\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">library(VariantAnnotation)<\/span><\/code><code><span class=\"code-snippet_outer\">devtools::install_github(<span class=\"code-snippet__string\">\"mrcieu\/gwasglue\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">#\u52a0\u8f7d<\/span><\/code><code><span class=\"code-snippet_outer\">library(gwasglue)<\/span><\/code><code><span class=\"code-snippet_outer\">library(TwoSampleMR)<\/span><\/code><code><span class=\"code-snippet_outer\">setwd(<span class=\"code-snippet__string\">\"D:\/R\/R-4.1.1\/library\/ldscr\"<\/span>)#\u6839\u636e\u81ea\u5df1\u6587\u4ef6\u60c5\u51b5\u8bbe\u7f6e\u8def\u5f84<\/span><\/code><code><span class=\"code-snippet_outer\">dat<- readVcf(<span class=\"code-snippet__string\">\"ukb-b-956.vcf.gz\"<\/span>) #\u8bfb\u5165GWAS\u7684summary\u7ed3\u5c40\/\u66b4\u9732\u6570\u636e\u7684VCF\u683c\u5f0f\u6587\u4ef6<\/span><\/code><code><span class=\"code-snippet_outer\">dat <-gwasvcf_to_TwoSampleMR(dat)#\u8f6c\u6362\u4e3aTwoSampleMR\u53ef\u4ee5\u8bc6\u522b\u7684\u683c\u5f0f<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5c0f\u56fe\u6e29\u99a8\u63d0\u793a\uff1a\u7531\u4e8eGWAS\u7684summary\u6570\u636e\u6587\u4ef6\u5927\u5c0f\u518d200-300MB\u5de6\u53f3\uff0c\u6240\u4ee5windows\u4e0b\u7684R\u53ef\u80fd\u8bfb\u53d6\u5931\u8d25\uff0c\u5efa\u8bae\u5728linux\u4e0b\u8fdb\u884c\u683c\u5f0f\u8f6c\u6362\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">dat\u6570\u636e\u6846\u7b2c3,4,5,6,9,11\u5217\uff1b\u8fd9\u91cc\u5206\u522b\u5bf9\u5e94\u7684\u662f”A2″,”A1″,”beta”,”se”,”N”,”SNP”<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">dat<- dat [, c(<span class=\"code-snippet__number\">3<\/span>:<span class=\"code-snippet__number\">6<\/span>,<span class=\"code-snippet__number\">9<\/span>,<span class=\"code-snippet__number\">11<\/span>)]<\/span><\/code><code><span class=\"code-snippet_outer\">colnames(dat)<-c(<span class=\"code-snippet__string\">\"A2\"<\/span>,<span class=\"code-snippet__string\">\"A1\"<\/span>,<span class=\"code-snippet__string\">\"beta\"<\/span>,<span class=\"code-snippet__string\">\"se\"<\/span>,<span class=\"code-snippet__string\">\"N\"<\/span>,<span class=\"code-snippet__string\">\"SNP\"<\/span>)#\u5bf9\u6570\u636e\u6587\u4ef6\u91cd\u547d\u540d<\/span><\/code><code><span class=\"code-snippet_outer\">#\u6700\u540e\u5c06\u6587\u4ef6\u4fdd\u5b58\u4e3atxt.gz\u683c\u5f0f<\/span><\/code><code><span class=\"code-snippet_outer\">write.table(dat, gzfile(<span class=\"code-snippet__string\">\"ukb-b-7178-sumstats-munged.txt.gz\"<\/span>), <\/span><\/code><code><span class=\"code-snippet_outer\"> sep = <span class=\"code-snippet__string\">\"t\"<\/span>, row.names = FALSE)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 1.8;letter-spacing: 1.5px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u6570\u636e\u683c\u5f0f\u5904\u7406\u6210\u529f\u5373\u53ef\u6309\u7167\u4e0a\u8ff0\u6d41\u7a0b\u4f30\u7b97\u9057\u4f20\u5ea6\u548c\u9057\u4f20\u76f8\u5173\u6027<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u5173\u4e8eGWAS summary \u6570\u636e\u9057\u4f20\u5ea6\u548c\u9057\u4f20\u76f8\u5173\u6027\u4f30\u7b97\u5c0f\u56fe\u5c31\u4ecb\u7ecd\u5b8c\u6bd5\u4e86\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u7262\u8bb0\u5404\u4e2a\u6587\u4ef6\u7684\u7ed3\u6784\u4fe1\u606f\uff0c\u8fd9\u5728\u540e\u7eed\u7684\u6570\u636e\u5206\u6790\u4e2d\u975e\u5e38\u91cd\u8981\u3002<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;border-color: rgb(176, 176, 176);padding: 7px;\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: rgba(249, 238, 237, 0.5);padding: 18px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;font-size: 14px;letter-spacing: 2px;line-height: 1.8;\">\n<p style=\"white-space: normal;\">\u6b22\u8fce\u4f7f\u7528\uff1a\u4e91\u751f\u4fe1\u751f\u7269\u4fe1\u606f\u5b66\u5e73\u53f0\uff08 http:\/\/www.biocloudservice.com\/home.html\uff09\uff0c\u4e86\u89e3\u66f4\u591a\u751f\u4fe1\u77e5\u8bc6\u4e0e\u6280\u5de7\u5206\u6790\u3002<\/p>\n<p style=\"white-space: normal;\">\u8bf7\u671f\u5f85\u5c0f\u56fe\u7684\u4e0b\u4e00\u671f\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u77e5\u8bc6\u5206\u4eab\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<\/section>\n<section style=\"text-align: justify;font-size: 14px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u6b22\u8fce\u4f7f\u7528\uff1a\u4e91\u751f\u4fe1\u5e73\u53f0 ( http:\/\/www.biocloudservice.com\/home.html)<\/p>\n<\/section>\n<section style=\"transform: scale(0.5);transform-origin: center center;margin-top: -65px;margin-bottom: -65px;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_yibFsicLO4HWo2JC2zqQFibb8ecSdQ.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/2wJ7bWfS0QtP2KYQDSKM5aGmnm1vwEufxlWUvOOiciaBzW6blF8RicdMzBw8EGyibFsicLO4HWo2JC2zqQFibb8ecSdQ\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"258\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:26.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:26.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;background-color: rgb(249, 174, 165);padding: 10px 0px;\" width=\"96.3700%\">\n<section style=\"line-height: 1;text-align: center;font-size: 17px;color: rgb(255, 255, 255);letter-spacing: 5px;\" powered-by=\"xiumi.us\">\n<p><strong>\u5f80\u671f\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:26.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:26.classicTable1:1.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<section style=\"font-size: 14px;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247485058&idx=1&sn=01e2ab90b374e9a97c88722233b0036f&chksm=c1b17b7ff6c6f269d29dc41ef67408d077cd202ba1262833fa98df4ca178d7fc302b1158a7f4&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u56fe\u5b66umap\u56fe-\u5229\u7528ggplot2\u5b9a\u5236\u81ea\u5df1\u7406\u60f3\u7684umap\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u56fe\u5b66umap\u56fe-\u5229\u7528ggplot2\u5b9a\u5236\u81ea\u5df1\u7406\u60f3\u7684umap\u56fe\uff01\uff01<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:26.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:26.classicTable1:2.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<section style=\"font-size: 14px;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247485041&idx=1&sn=89eaefdfef4673d70641bd46f874e28f&chksm=c1b17b8cf6c6f29a28a17e43cb872c3c5fe32044e2058b6aa488b0880b86fe8dc6c1abdc9c0b&scene=21#wechat_redirect\" textvalue=\"\u4fdd\u59c6\u7ea7\u6559\u7a0b-\u5c0f\u56fe\u6559\u4f60\u5982\u4f55\u4f7f\u7528ggrisk\u9ad8\u6548\u7684\u7ed8\u5236\u98ce\u9669\u56e0\u5b50\u8054\u52a8\u56fe\uff01\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u4fdd\u59c6\u7ea7\u6559\u7a0b-\u5c0f\u56fe\u6559\u4f60\u5982\u4f55\u4f7f\u7528ggrisk\u9ad8\u6548\u7684\u7ed8\u5236\u98ce\u9669\u56e0\u5b50\u8054\u52a8\u56fe\uff01\uff01\uff01<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:26.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:26.classicTable1:3.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<section style=\"font-size: 14px;letter-spacing: 1px;\" powered-by=\"xiumi.us\">\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247485026&idx=1&sn=ab42053deabf774b59be8627812bb600&chksm=c1b17b9ff6c6f289d6c01ddc21b4a94241116879fc3ca9b33ca033cebfde972debf2c7f2de6d&scene=21#wechat_redirect\" textvalue=\"\u4e09\u5206\u949f\u5b66\u4f1a\u7528ggridges\u753b\u5cf0\u5ce6\u56fe\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u4e09\u5206\u949f\u5b66\u4f1a\u7528ggridges\u753b\u5cf0\u5ce6\u56fe<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\ud83d\udc47\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8fdb\u5165\u7f51\u5740<\/p>\n<\/section>\n<p style=\"display: none;margin-bottom: 24px;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<div class=\"msg_source_url\"><a href=\"http:\/\/www.biocloudservice.com\/home.html\" target=\"_blank\" rel=\"noopener\">\u9605\u8bfb\u539f\u6587<\/a><\/div>\n<p><\/content><\/p>\n<div class=\"msg_source_url\"><a href=\"http:\/\/www.biocloudservice.com\/home.html\" target=\"_blank\" rel=\"noopener\">\u9605\u8bfb\u539f\u6587<\/a><\/div>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u542c\u8bf4\u53ef\u4ee5\u7528R\u8bed\u8a00\u5b8c\u6210\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u9057\u4f20\u76f8\u5173\uff0c\u4f60\u6765\u4e0d\u6765\u5b66\uff1f \u5c0f\u56fe \u751f\u4fe1\u679c &nbs […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/55979"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=55979"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/55979\/revisions"}],"predecessor-version":[{"id":55987,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/55979\/revisions\/55987"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=55979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=55979"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=55979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}