{"id":56131,"date":"2024-06-16T17:29:03","date_gmt":"2024-06-16T09:29:03","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=56131"},"modified":"2024-06-16T17:29:03","modified_gmt":"2024-06-16T09:29:03","slug":"%e5%a6%88%e5%a6%88%e5%86%8d%e4%b9%9f%e4%b8%8d%e6%8b%85%e5%bf%83%e6%88%91%e7%9a%84%e5%8d%95%e7%bb%86%e8%83%9e%e5%88%86%e6%9e%90%e4%ba%86%ef%bc%8c%e7%82%b9%e5%87%bb%e5%b0%b1%e9%80%81%e7%9a%84%e9%80%86-2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=56131","title":{"rendered":"\u5988\u5988\u518d\u4e5f\u4e0d\u62c5\u5fc3\u6211\u7684\u5355\u7ec6\u80de\u5206\u6790\u4e86\uff0c\u70b9\u51fb\u5c31\u9001\u7684\u9006\u5929\u5916\u6302\uff01\u5929\u6d25\u533b\u79d1\u5927\u5b66\u6768\u626c\u56e2\u961f\u4e24\u4e2a\u6708\u63a5\u6536\u5230\u53d1\u8868\uff0c\u73a9\u51fa\u6df1\u5ea6\u5b66\u4e60\u65b0\u9ad8\u5ea6\uff01"},"content":{"rendered":"


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href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzk0MDQ2MTU0Mg==&mid=2247494032&idx=1&sn=715f259befc3fb3def7d1f73e38e6c0b\" target=\"_blank\" title=\"\u9605\u8bfb\u539f\u6587\" rel=\"noopener\">http:\/\/mp.weixin.qq.com\/s?__biz=Mzk0MDQ2MTU0Mg==&mid=2247494032&idx=1&sn=715f259befc3fb3def7d1f73e38e6c0b<\/a><\/p>\n<\/div>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\" data-mpa-powered-by=\"yiban.io\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100015224\" data-ratio=\"0.2222222222222222\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-03_\u300c\u8f6c\u300d\u5988\u5988\u518d\u4e5f\u4e0d\u62c5\u5fc3\u6211\u7684\u5355\u7ec6\u80de\u5206\u6790\u4e86\uff0c\u70b9\u51fb\u5c31\u9001\u7684\u9006\u5929\u5916\u6302\uff01\u5929\u6d25\u533b\u79d1\u5927\u5b66\u6768\u626c\u56e2\u961f\u4e24\u4e2a\u6708\u63a5\u6536\u5230\u53d1\u8868\uff0c\u73a9\u51fa\u6df1\u5ea6\u5b66\u4e60\u65b0\u9ad8\u5ea6\uff01\/1_r0Gd7iaumIGMiaia97aHFV15nrpdzw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxQW8Zek7Noib2uBhB3ZE3yMxI2Hfic7cGTdPYiacicg47jficdr5BVr0Gd7iaumIGMiaia97aHFV15nrpdzw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"900\" style=\"\" \/><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f(scRNA-seq)\u5728\u80bf\u7624\u7814\u7a76\u7684\u8fd0\u7528\u53d1\u6325\u4e86\u5de8\u5927\u7684\u4f5c\u7528\u3002\u65e0\u8bba\u662f\u7533\u8bf7\u8bfe\u9898\u57fa\u91d1\uff0c\u8fd8\u662f\u6211\u4eec\u505a\u751f\u4fe1\u6316\u6398\uff0c\u4e24\u8005\u4e00\u76f4\u90fd\u662f\u4e34\u5e8a\u533b\u751f\u548c\u79d1\u7814\u4eba\u7684\u201c\u91cd\u70b9\u7167\u987e\u5bf9\u8c61\u201d\uff01\u5355\u7ec6\u80de\u6570\u636e\u7684\u5206\u6790\u59ff\u52bf\u4f60\u5b66\u4f1a\u4e86\u591a\u5c11\u5440\uff1f<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">~~~<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;text-indent: 24pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 200%;font-family: "Times New 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10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u65b0\u6587\u732e\u91cc\u80fd\u628a\u5355\u7ec6\u80de\u6570\u636e\u6413\u51fa\u65b0\u706b\u82b1\u7684\u5de5\u5177\u5927\u5bb6\u53ef\u4e00\u5b9a\u8981\u8bd5\u4e00\u8bd5\uff01\u4eca\u5929\u5c0f\u9014\u9001\u4e0a\u4e00\u4e2a<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">SCI\u5916\u6302CellNetdb<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\"> (http:\/\/www.bioailab.com:3838\/CellNetdb)\uff0c<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">\u80bf\u7624\u5fae\u73af\u5883\u7ec6\u80de\u5206\u578b\u3001\u57fa\u56e0\u8868\u8fbe\u3001\u7ec6\u80de\u901a\u8def<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6837\u6837\u7cbe\u901a\u4e0d\u8bf4\uff0c<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">\u91cd\u5efa\u80bf\u7624\/\u514d\u75ab\u7ec6\u80de\u4e92\u4f5c\u7f51\u7edc<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u7b80\u76f4\u662f\u4e0d\u53ef\u591a\u5f97\u7684\u6740\u62db\u5440\uff01\u5e72\u8d27\u592a\u591a\uff0c\u9a6c\u4e0a\u5f00\u8bb2\uff1a<\/span><\/span><\/section>\n<section style=\"font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: windowtext;font-weight: normal;\">1.<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6536\u96c6<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">44\u79cd\u80bf\u7624\u7684scRNA-seq\u6570\u636e\u8fdb\u884c\u65e0\u76d1\u7763\u805a\u7c7b\uff0c\u4f7f\u7528SCINET\u91cd\u5efa\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u7684\u4e92\u4f5c\u7f51\u7edc<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u3002<\/span><\/span><\/section>\n<section style=\"font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: windowtext;font-weight: normal;\">2.<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5f00\u53d1\u51fa<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">CellNetdb\uff0c\u53ef\u63d0\u4f9b\u57fa\u4e8e\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7684\u7ec6\u80de\u5206\u7c7b\u6982\u8ff0\u3001\u53ef\u89c6\u5316\u57fa\u56e0\u8868\u8fbe\u6c34\u5e73\u548c\u4fe1\u53f7\u901a\u8def\u3001\u63a2\u7a76\u4e0d\u540c\u7ec6\u80de\u95f4\u7684\u4e92\u4f5c\u7f51\u7edc<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u3002<\/span><\/span><\/section>\n<section style=\"font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: windowtext;font-weight: normal;\">3.<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">\u4f7f\u7528SCINET\u5f15\u5165\u7684\u62d3\u6251\u7279\u5f02\u6027(topS)\uff0c\u6d4b\u91cf\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u5185\u89c2\u5bdf\u5230\u7684\u57fa\u56e0\u603b\u4f53\u4e92\u4f5c\u5f3a\u5ea6\u4e0e\u4ece\u968f\u673a\u6a21\u578b\u4e2d\u83b7\u5f97\u7684\u9884\u671f\u5f3a\u5ea6\u4e4b\u95f4\u7684\u504f\u5dee<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: windowtext;font-weight: normal;\">4.<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">\u75be\u75c5\u76f8\u5173\u57fa\u56e0\u96c6\u53cd\u5377\u79ef\u5230\u5355\u4e2a\u7ec6\u80de\u7c7b\u578b<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4e2d\uff0c\u901a\u8fc7<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">\u7f51\u7edc\u8fde\u901a\u6027\u5206\u6790\u786e\u5b9a\u4e0e\u9884\u540e\u76f8\u5173\u7684\u7ec6\u80de\u7c7b\u578b<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u3002<\/span><\/span><\/section>\n<section style=\"font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: windowtext;font-weight: normal;\">5.<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5728\u4e0d\u540c\u5b9e\u4f53\u80bf\u7624\u7684\u6076\u6027\u7ec6\u80de\u68c0\u6d4b\u7279\u5f02\u6027\u7f51\u7edc\uff0c<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">\u5e94\u7528\u7f51\u7edc\u7fa4\u843d\u68c0\u6d4b\u65b9\u6cd5Infomap\u8bc6\u522b\u4e86\u80bf\u7624\u76f8\u5173\u7684\u6838\u5fc3\u5b50\u7f51\u7edc<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u3002<\/span><\/span><\/section>\n<section style=\"font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: windowtext;font-weight: normal;\">6.<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5728RWR\u3001GenePanda\u3001Node2Vec\u548cDIAMOnD\u56db\u79cd\u65b9\u6cd5\u4e2d\u8bc4\u4f30\u51fa<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">RWR\u5728\u5229\u7528\u751f\u7269\u7f51\u7edc\u5bf9\u98ce\u9669\u57fa\u56e0\u8fdb\u884c\u4f18\u5148\u6392\u5e8f\u8868\u73b0\u66f4\u597d<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u3002\u8fd8\u53ef\u9488\u5bf9\u4e0d\u540c\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u7684\u4e92\u4f5c\u7ec4\u7f51\u7edc\u6765\u786e\u5b9a\u98ce\u9669\u57fa\u56e0\u7684\u4f18\u5148\u7ea7\u3002<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\" background:=\"background:\" mso-highlight:=\"mso-highlight:\">\u53ea\u662f\u770b\u4e86\u8fd9\u51e0\u6761\u603b\u7ed3\u5c0f\u9014\u5df2\u7ecf\u5fc3\u6f6e\u6f8e\u6e43\u4e86\u8036\uff01\u5de5\u5177\u987a\u624b\uff0c\u8c01\u7528\u7740\u4e0d\u9999\u554a\uff01\u60f3\u4e2d\u9ad8\u5206\u671f\u520a\uff0c\u4e3a\u81ea\u5df1\u7684\u5c0f\u8bba\u6587\u9526\u4e0a\u6dfb\u82b1\u7684\u540c\u5b66\u4eec\u5feb\u6765\u8bd5\u8bd5\u5427\uff01<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(255, 0, 0);font-weight: bold;text-decoration: underline;background: rgb(255, 255, 0);\">\u5bf9\u6570\u636e\u6316\u6398\u548c\u6df1\u5ea6\u5b66\u4e60\u611f\u5174\u8da3\u4f46\u6280\u672f\u53d7\u9650\u7684\uff0c\u6216\u662f\u5bf9\u751f\u4fe1\u6570\u636e\u7edf\u8ba1\u5206\u6790\u8ff7\u832b\u7684\u5b9d\u5b50\u4eec\uff0c\u5feb\u6765\u626b\u7801\u8054\u7cfb\u5c0f\u9014\u590d\u73b0\u5427\uff01<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\" background:=\"background:\" mso-highlight:=\"mso-highlight:\">~<\/span><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017749\" data-ratio=\"1\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-03_\u300c\u8f6c\u300d\u5988\u5988\u518d\u4e5f\u4e0d\u62c5\u5fc3\u6211\u7684\u5355\u7ec6\u80de\u5206\u6790\u4e86\uff0c\u70b9\u51fb\u5c31\u9001\u7684\u9006\u5929\u5916\u6302\uff01\u5929\u6d25\u533b\u79d1\u5927\u5b66\u6768\u626c\u56e2\u961f\u4e24\u4e2a\u6708\u63a5\u6536\u5230\u53d1\u8868\uff0c\u73a9\u51fa\u6df1\u5ea6\u5b66\u4e60\u65b0\u9ad8\u5ea6\uff01\/3_B2jkicacLzPjw4xMSqVvoucZjonVDA.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 186px;height: 186px;\" \/><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><br \/><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010366\" data-ratio=\"0.3489655172413793\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_zImX8f75NHl3skfG8Smia04wLnT2bw.png?resize=553%2C193\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQOjqicmKKBVpfjJeI0DdwSLiazBziajqmVwANwCWhwTNmmibOz4zImX8f75NHl3skfG8Smia04wLnT2bw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"725\" height=\"193 .07000732421875\" width=\"553 .2100219726562\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: -21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);font-style: italic;\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u9898\u76ee\uff1a\u8de8\u8d8a44\u79cd\u4eba\u7c7b\u80bf\u7624\u7c7b\u578b\u7684\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u4e92\u4f5c\u7ec4\u7f51\u7edc\u56fe\u8c31<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: -21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);font-style: italic;\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u671f\u520a\uff1aGenome Medicine<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: -21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">12.3<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: -21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e74<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">2<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6708<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: -21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><br \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u7814\u7a76\u80cc\u666f<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u57fa\u56e0\u4e92\u4f5c\u7f51\u7edc\u7684\u7834\u574f\u53ef\u80fd\u635f\u5bb3\u7ec6\u80de\u529f\u80fd\uff0c\u5bfc\u81f4\u4eba\u7c7b\u80bf\u7624\u7b49\u75be\u75c5\u3002\u4eba\u4eec\u6295\u5165\u4e86\u5927\u91cf\u7684\u7cbe\u529b\u6765\u6784\u5efa\u53c2\u8003\u4ea4\u4e92\u7ec4\u7f51\u7edc\u3002\u7136\u800c\u7cbe\u786e\u7684\u57fa\u56e0\u4e92\u4f5c\u7f51\u7edc\u53ef\u80fd\u5728\u65f6\u7a7a\u80cc\u666f\u4e0b\u88ab\u91cd\u5851\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">\u80bf\u7624\u662f\u7531\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u7ec4\u6210\u7684\u5f02\u8d28\u6027\u6df7\u5408\u7269\u3002scRNA-seq\u5df2\u88ab\u5e7f\u6cdb\u7528\u4e8e\u89e3\u51b3\u80bf\u7624\u5fae\u73af\u5883\u7684\u7ec6\u80de\u5f02\u8d28\u6027\u3002\u5229\u7528\u4eba\u7c7b\u6076\u6027\u80bf\u7624\u79ef\u7d2f\u7684scRNA-seq\u6570\u636e\u6765\u68c0\u6d4b\u7ec6\u80de\u5f02\u8d28\u6027\u4e2d\u7684\u57fa\u56e0\u4e92\u4f5c\u7f51\u7edc\uff0c\u53ef\u4ee5\u8865\u5145\u57fa\u4e8e\u8868\u8fbe\u7684\u65b9\u6cd5\u6765\u9610\u660e\u6f5c\u5728\u7684\u5206\u5b50\u673a\u5236\u3002<\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6570\u636e\u6765\u6e90<\/span><\/section>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" style=\"margin-left: 0px;border-width: initial;border-style: none;border-color: initial;border-collapse: collapse;width: 100%;\">\n<tbody>\n<tr>\n<td width=\"136\" valign=\"top\" style=\"width:104.65pt;background:#9CC4E6;border-top:solid #5B9BD5 1.5pt;border-left:solid #5B9BD5 1.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6570\u636e\u96c6\/\u961f\u5217<\/span><\/section>\n<\/td>\n<td width=\"85\" valign=\"top\" style=\"width:65.85pt;background:#9CC4E6;border-top:solid #5B9BD5 1.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6570\u636e\u5e93<\/span><\/section>\n<\/td>\n<td width=\"90\" valign=\"top\" style=\"width:69.5pt;background:#9CC4E6;border-top:solid #5B9BD5 1.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6570\u636e\u7c7b\u578b<\/span><\/section>\n<\/td>\n<td width=\"241\" valign=\"top\" style=\"width:186.1pt;background:#9CC4E6;border-top:solid #5B9BD5 1.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u8be6\u7ec6\u4fe1\u606f<\/span><\/section>\n<\/td>\n<\/tr>\n<tr style=\"height:29.65pt;\">\n<td width=\"136\" valign=\"top\" style=\"width:104.65pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:29.65pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;font-size: 16px;letter-spacing: 1px;\">GSE137804<\/span><\/section>\n<\/td>\n<td width=\"85\" valign=\"top\" style=\"width:65.85pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:29.65pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;font-size: 16px;letter-spacing: 1px;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"90\" valign=\"top\" style=\"width:69.5pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:29.65pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">scRNA-seq<\/span><\/section>\n<\/td>\n<td width=\"241\" valign=\"top\" style=\"width:186.1pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:29.65pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;font-size: 16px;letter-spacing: 1px;\">\u901a\u8fc710X Genomics\u5e73\u53f0\u751f\u6210\u6765\u81ea16\u540d\u795e\u7ecf\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u768416\u4e2a\u539f\u53d1\u6027\u80bf\u7624\u3001\u6765\u81ea6\u4e2a\u6d41\u4ea7\u80ce\u513f\u76844\u4e2a\u80be\u4e0a\u817a\u7ec4\u7ec7\u548c2\u4e2a\u80da\u80ce\u7684\u5355\u7ec6\u80demRNA\u8c31<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"136\" valign=\"top\" style=\"width:104.65pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;font-size: 16px;letter-spacing: 1px;\">GSE148673<\/span><\/section>\n<\/td>\n<td width=\"85\" valign=\"top\" style=\"width:65.85pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;font-size: 16px;letter-spacing: 1px;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"90\" valign=\"top\" style=\"width:69.5pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">scRNA-seq<\/span><\/section>\n<\/td>\n<td width=\"241\" valign=\"top\" style=\"width:186.1pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Verdana;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-style: normal;font-size: 16px;letter-spacing: 1px;\">21\u4e2a\u80bf\u7624\u768446,501\u4e2a\u5355\u7ec6\u80de<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"136\" valign=\"top\" style=\"width:104.65pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;font-size: 16px;letter-spacing: 1px;\">GSE168652<\/span><\/section>\n<\/td>\n<td width=\"85\" valign=\"top\" style=\"width:65.85pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;letter-spacing: 1px;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"90\" valign=\"top\" style=\"width:69.5pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">scRNA-seq<\/span><\/section>\n<\/td>\n<td width=\"241\" valign=\"top\" style=\"width:186.1pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;font-size: 16px;letter-spacing: 1px;\">\u5bab\u9888\u764c\u60a3\u8005\u7684\u764c\u7ec4\u7ec7\u548c\u6b63\u5e38\u90bb\u8fd1\u7ec4\u7ec7\u8fdb\u884c\u4e86\u5355\u7ec6\u80deRNA\u6d4b\u5e8f<\/span><\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;letter-spacing: 1px;\">\uff08\u56e0\u7bc7\u5e45\u6709\u9650\uff0c\u5982\u9700\u67e5\u770b\u5b8c\u6574\u6570\u636e\u96c6\u8bf7\u9886\u53d6\u5168\u6587\u67e5\u770b\uff09<\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u7814\u7a76\u601d\u8def<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;text-decoration: none;\">\u4f5c\u8005\u6536\u96c644\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u7684563\u4f8b\u60a3\u8005\u7684\u5355\u7ec6\u80deRNA-seq\u6570\u636e\u3002\u786e\u5b9a\u4e86\u80bf\u7624\u4e2d\u7684\u5404\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u901a\u8fc7\u534f\u8c03\u8de8\u80bf\u7624\u7c7b\u578b\u7684\u7ec6\u80de\u7c7b\u578b\u6ce8\u91ca\uff0c\u6784\u5efa\u4e86\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883(TIMEs)\u4e2d\u4e0d\u540c\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u7684\u6cdb\u80bf\u7624\u56fe\u8c31\u3002\u521b\u5efa\u4e86\u4e00\u4e2a\u6570\u636e\u95e8\u6237\uff0cCellNetdb (http:\/\/www.bioai lab.com:3838\/CellNetdb)\uff0c\u53ef\u6d4f\u89c8\u3001\u67e5\u8be2\u548c\u53ef\u89c6\u5316\u7ec6\u80de\u7c7b\u578b\u7279\u5b9a\u7684\u4ea4\u4e92\u7ec4\u7f51\u7edc\u3002\u4f53\u7ec6\u80de\u7a81\u53d8\u8c31\u88ab\u6620\u5c04\u5230\u4e92\u4f5c\u7ec4\u7f51\u7edc\u3002\u5bf9\u7f51\u7edc\u8fdb\u884c\u4e86\u529f\u80fd\u5206\u6790\u548c\u6807\u6ce8\u3002\u751f\u5b58\u5206\u6790\u88ab\u7eb3\u5165\u63ed\u793a\u4e0e\u7f51\u7edc\u6709\u5173\u7684\u57fa\u56e0\u7684\u9884\u540e\u76f8\u5173\u6027\u3002\u901a\u8fc7\u5bf9\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7f51\u7edc\u7684\u8fde\u901a\u6027\u5206\u6790\uff0c\u53ef\u5c06\u9884\u540e\u7279\u5f81\u53cd\u5377\u79ef\u5230\u7ec6\u80de\u7c7b\u578b\u4e2d\uff0c\u5e76\u53d1\u73b0ITGB1\u7684\u9884\u540e\u4f5c\u7528\u4e0eCAF\u4ecb\u5bfc\u7684\u80bf\u7624\u8fdb\u5c55\u6709\u5173\u3002\u5e94\u7528SCINET\u65b9\u6cd5\u91cd\u5efa\u4e86\u9488\u5bf9\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u548c\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u7684\u4e92\u4f5c\u7ec4\u7f51\u7edc<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;text-decoration: none;\">\u3002\u6b64\u5916\uff0c\u8fd8\u9274\u5b9a\u4e86\u7f51\u7edc\u4e2d\u4e0e\u9884\u540e\u76f8\u5173\u7684\u57fa\u56e0\u3002\u6211\u4eec\u8fd8\u7814\u7a76\u4e86\u7ec6\u80de\u95f4\u901a\u8baf\uff0c\u4ee5\u7814\u7a76\u57fa\u56e0\u4e92\u4f5c\u5982\u4f55\u8c03\u8282\u7ec6\u80de\u95f4\u4e92\u4f5c\u3002<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6b64\u5916\uff0c\u6211\u4eec\u53d1\u73b0\u8fd9\u4e9b\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u4e92\u4f5c\u7ec4\u7f51\u7edc\u80fd\u591f\u533a\u5206\u62d3\u6251\u7279\u5f02\u6027\u57fa\u56e0\uff0c\u5176\u603b\u4f53\u4e92\u4f5c\u5f3a\u5ea6\u662f\u9ad8\u5ea6\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7684\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010369\" data-ratio=\"1.005966587112172\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_bfFQ70QQic5UaFgV8fN4BzTDZP5BHQ.png?resize=553%2C556\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQOjqicmKKBVpfjJeI0DdwSLoJR8SB6icyTwtVPPobU1UV6ia1QibfFQ70QQic5UaFgV8fN4BzTDZP5BHQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"838\" height=\"556 .6099853515625\" width=\"553 .280029296875\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">\u56fe1  \u8bbe\u8ba1\u6d41\u7a0b<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;text-decoration: underline;font-size: 16px;letter-spacing: 1px;\"><o:p><\/o:p><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u4e3b\u8981\u7ed3\u679c<\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 0pt;text-indent: 0pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;letter-spacing: 1px;\">1. 44\u79cd\u80bf\u7624\u7c7b\u578b\u7684\u5927\u89c4\u6a21\u5355\u7ec6\u80de\u56fe\u8c31<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u6536\u96c6\u5904\u7406\u4e8644\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u7684scRNA-seq\u6570\u636e\uff0c\u5305\u62ec36\u79cd\u5b9e\u4f53\u80bf\u7624\u548c8\u79cd\u8840\u6db2\u6076\u6027\u80bf\u7624(\u56fe2)\u3002\u5bf9\u6bcf\u79cd\u80bf\u7624\u6574\u5408\u4e86\u4e0d\u540c\u6837\u672c\u7684scRNA-seq\u6570\u636e\uff0c\u8fdb\u884c\u65e0\u76d1\u7763\u805a\u7c7b\u3002\u5728\u5b9e\u4f53\u7624\u4e2d\u603b\u5171\u6ce8\u91ca\u4e8635\u79cd\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\uff0c\u5728\u8840\u6db2\u6076\u6027\u80bf\u7624\u4e2d\u6ce8\u91ca\u4e8614\u79cd\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">\u5c06\u4e0d\u540c\u5b9e\u4f53\u7624\u7684\u6ce8\u91caCD4+ T\u7ec6\u80de\u3001CD8+ T\u7ec6\u80de\u3001B\u7ec6\u80de\u548c\u9ad3\u6837\u7ec6\u80de\u4e0e\u6279\u91cf\u6548\u5e94\u6821\u6b63\u76f8\u7ed3\u5408\uff0c\u5b9a\u4e49\u4e0d\u540c\u5b9e\u4f53\u7624\u7c7b\u578b\u7684TIME\u666f\u89c2\uff0c\u5efa\u7acb\u4e86422,761\u4e2a\u514d\u75ab\u7ec6\u80de\u7684\u5927\u89c4\u6a21\u6cdb\u80bf\u7624\u56fe\u8c31\u3002\u968f\u540e\u8fdb\u884c\u65e0\u76d1\u7763\u7684\u57fa\u4e8e\u56fe\u7684\u805a\u7c7b\uff0c\u8bc6\u522b\u6bcf\u79cd\u514d\u75ab\u7ec6\u80de\u7c7b\u578b\u7684\u5404\u79cd\u7ec6\u80de\u5b50\u96c6\u3002<\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010370\" data-ratio=\"0.6907407407407408\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-03_\u300c\u8f6c\u300d\u5988\u5988\u518d\u4e5f\u4e0d\u62c5\u5fc3\u6211\u7684\u5355\u7ec6\u80de\u5206\u6790\u4e86\uff0c\u70b9\u51fb\u5c31\u9001\u7684\u9006\u5929\u5916\u6302\uff01\u5929\u6d25\u533b\u79d1\u5927\u5b66\u6768\u626c\u56e2\u961f\u4e24\u4e2a\u6708\u63a5\u6536\u5230\u53d1\u8868\uff0c\u73a9\u51fa\u6df1\u5ea6\u5b66\u4e60\u65b0\u9ad8\u5ea6\uff01\/6_oR0fAx60ntglPBUfHfqhVrK75h29Og.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQOjqicmKKBVpfjJeI0DdwSLFxrKTr0o1zTh3hiacdRUDYxDDoR0fAx60ntglPBUfHfqhVrK75h29Og\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"690.3400268554688\" width=\"476.7400207519531\" \/><\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe<\/span><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;\">2  CellNetdb\u5404\u529f\u80fd\u6a21\u5757\u7684\u539f\u7406\u56fe\u7279\u5f81<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 0pt;text-indent: 0pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;\">2.  \u8de8\u8d8a\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u7684\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u4e92\u4f5c\u7ec4\u7f51\u7edc\u56fe\u8c31<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u4f7f\u7528SCINET(\u4e00\u79cd\u4ece\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u63a8\u65ad\u57fa\u56e0\u4e92\u4f5c\u7684\u53c2\u8003\u6307\u5bfc\u65b9\u6cd5)\u91cd\u5efa\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u7684\u4e92\u4f5c\u7f51\u7edc\u3002\u91c7\u7528\u7684\u53c2\u8003\u4ea4\u4e92\u7ec4\u7f51\u7edc\u5305\u62ecSTRING\u3001ConsensusPathDB\u3001HumanNet\u548cReactome\u3002Reactome\u7684\u8282\u70b9\u6570\u548c\u8fb9\u6570\u90fd\u6bd4\u5176\u4ed6\u7f51\u7edc\u5c11,\u5f15\u5bfc\u7f51\u7edc\u7684\u89c4\u6a21\u4f4e\u4e8e\u5176\u4ed6\u7f51\u7edc\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u6b64\u5916\u4f5c\u8005\u6bd4\u8f83\u4e86\u7531\u5404\u79cd\u53c2\u8003\u7f51\u7edc\u5f15\u5bfc\u7684\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7f51\u7edc\u3002\u6027\u80fd\u7531\u57fa\u56e0\u96c6\u6062\u590d\u4efb\u52a1\u7684\u771f\u5b9eAUPRC\u76f8\u5bf9\u4e8e\u6765\u81ea\u7a0b\u5ea6\u5339\u914d\u7684\u96f6\u7f51\u7edc\u7684AUPRC\u80cc\u666f\u7684\u7a33\u5065z\u5206\u6570\u51b3\u5b9a\u3002\u6027\u80fd\u589e\u76ca\u8ba1\u7b97\u4e3a\u7ed9\u5b9a\u7f51\u7edc\u7684AUPRC\u4e0e\u5176\u7a7a\u7f51\u7edc\u7684\u4e2d\u503cAUPRC\u4e4b\u95f4\u7684\u5dee\uff0c\u9664\u4ee5\u5176\u7a7a\u7f51\u7edc\u7684\u4e2d\u503cAUPRC\u3002\u4ee5\u6076\u6027\u7ec6\u80de\u7279\u5f02\u6027\u7f51\u7edc\u4e3a\u4f8b\uff0c\u6027\u80fd\u548c\u6027\u80fd\u589e\u76ca\u4e4b\u95f4\u5b58\u5728\u5f88\u5f3a\u7684\u76f8\u5173\u6027\uff0c\u7531STRING\u5f15\u5bfc\u7684\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7f51\u7edc\u8868\u73b0\u51fa\u6700\u4f73\u7684\u6574\u4f53\u6027\u80fd\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 0pt;text-indent: 0pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;\">3.  CellNetdb<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u8bbf\u95ee<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u4f5c\u8005\u5f00\u53d1\u51faCellNetdb\u3002\u201cTaxonomy\u201d\u9875\u9762\u63d0\u4f9b\u4e86\u57fa\u4e8e\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7684\u7ec6\u80de\u5206\u7c7b\u6982\u8ff0(\u56fe1)\uff0c\u8fd8\u5305\u62ec\u6cdb\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u7684\u7ec6\u80de\u5206\u7c7b\u4fe1\u606f\u3002\u4f7f\u7528\u7edf\u4e00\u6d41\u5f62\u8fd1\u4f3c\u548c\u6295\u5f71(UMAP)\u5141\u8bb8\u7528\u6237\u53ef\u89c6\u5316\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u4e8c\u7ef4\u8868\u793a\u548c\u6807\u8bb0\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u5706\u5f62\u56fe\u7528\u4e8e\u53ef\u89c6\u5316\u57fa\u4e8e\u805a\u5408\u4fe1\u53f7\u901a\u8def\u7684\u7ec6\u80de\u95f4\u901a\u4fe1\u3002\u6bcf\u79cd\u5355\u5143\u683c\u7c7b\u578b\u7684\u5355\u5143\u683c\u6570\u91cf\u663e\u793a\u5728\u6c47\u603b\u8868\u4e2d\uff0c\u53ef\u901a\u8fc7\u201csummary\u201d\u9762\u677f\u8bbf\u95ee\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u201cCellNet\u201d\u9875\u9762\u65e8\u5728\u7814\u7a76\u5177\u6709\u591a\u65b9\u9762\u529f\u80fd\u6a21\u5757\u7684\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u4e92\u4f5c\u7ec4\u7f51\u7edc(\u56fe1)\u3002\u4f5c\u8005\u4ee5LUAD\u7684MDK\u57fa\u56e0\u4e3a\u4f8b\u3002MDK\u5728\u5404\u79cd\u4eba\u7c7b\u80bf\u7624\u4e2d\u7ecf\u5e38\u4e0a\u8c03\uff0c\u901a\u8fc7\u9009\u62e9\u80ba\u817a\u764c\u548c\u4e0a\u76ae\u7ec6\u80de\uff0c\u53ef\u8f93\u5165MDK\uff0c\u53ef\u89c6\u5316MDK\u7684\u5c40\u90e8\u7f51\u7edc(\u56fe2B)\u3002\u53d1\u73b0MDK\u4e0eERBB2\u548cERBB3\u6709\u5f88\u5f3a\u7684\u8054\u7cfb\u3002\u6b64\u5916\uff0c\u201c\u8868\u8fbe\u201d\u548c\u201c\u7a81\u53d8\u201d\u9762\u677f\u5206\u522b\u63d0\u4f9b\u4e86MDK\u53ca\u5176\u90bb\u8fd1\u57fa\u56e0\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u548c\u4f53\u7ec6\u80de\u7a81\u53d8\u8c31(\u56fe2B,C)\u3002\u201cGO\u201d\u9762\u677f\u663e\u793a\uff0c\u5728\u67e5\u8be2\u7684\u5c40\u90e8\u7f51\u7edc\u4e2d\uff0c\u4e0e\u7ec6\u80de\u7c98\u9644\u3001\u751f\u957f\u548cERBB2\u4fe1\u53f7\u901a\u8def\u76f8\u5173\u7684GO\u901a\u8def\u663e\u8457\u5bcc\u96c6(\u56fe2D)\u3002\u5c40\u90e8\u7f51\u7edc\u663e\u793a\u4e0e\u75be\u75c5\u6076\u5316\u3001\u6076\u6027\u80bf\u7624\u548c\u764c\u75c7\u663e\u8457\u76f8\u5173(\u56fe2E)\u3002\u201c\u751f\u5b58\u201d\u9762\u677f\u4e2d\uff0c\u90bb\u8fd1\u57fa\u56e0SLC2A1\u4e0eLUAD\u60a3\u8005\u7684\u603b\u751f\u5b58\u76f8\u5173(\u56fe2F)\u3002\u201c\u901a\u4fe1\u201d\u9762\u677f\u5141\u8bb8\u7528\u6237\u8c03\u67e5\u672c\u5730\u7f51\u7edc\u5982\u4f55\u5f71\u54cd\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e4b\u95f4\u7684\u7ec6\u80de-\u7ec6\u80de\u4e92\u4f5c\u3002\u53d1\u73b0\u9ad3\u7cfb\u7ec6\u80de\u901a\u8fc7MDK\u4e0e\u5176\u53d7\u4f53LRP1\u7684\u4e92\u4f5c\u5bf9\u6076\u6027\u4e0a\u76ae\u7ec6\u80de\u505a\u51fa\u53cd\u5e94(\u56fe2G)\u3002\u6b64\u5916\u53d1\u73b0MDK-LRP1\u5bf9\u53c2\u4e0e\u6210\u7ea4\u7ef4\u7ec6\u80de\u5bf9\u6076\u6027\u4e0a\u76ae\u7ec6\u80de\u7684\u53cd\u5e94\u3002   <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 0pt;text-indent: 0pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;letter-spacing: 1px;\">4.  \u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7f51\u7edc\u63ed\u793a\u4e86\u5177\u6709\u4f18\u5148\u7ec6\u80de\u7c7b\u578b\u5f71\u54cd\u7684\u62d3\u6251\u7279\u5f02\u6027\u57fa\u56e0<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u4f5c\u8005\u4f7f\u7528SCINET\u5f15\u5165\u7684\u4e00\u79cd\u79f0\u4e3a\u62d3\u6251\u7279\u5f02\u6027(topS)\u7684\u6307\u6807\uff0c\u6d4b\u91cf\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u5185\u89c2\u5bdf\u5230\u7684\u57fa\u56e0\u603b\u4f53\u4e92\u4f5c\u5f3a\u5ea6\u4e0e\u4ece\u968f\u673a\u6a21\u578b\u4e2d\u83b7\u5f97\u7684\u9884\u671f\u5f3a\u5ea6\u4e4b\u95f4\u7684\u504f\u5dee\uff0c\u5728\u91cd\u65b0\u6392\u5217\u7ec6\u80de\u7c7b\u578b\u7279\u5b9a\u4e92\u4f5c\u5f3a\u5ea6\u7684\u540c\u65f6\u4fdd\u7559\u4e86\u7f51\u7edc\u62d3\u6251\u7ed3\u6784\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4ee5\u6cdb\u80bf\u7624\u7684\u9aa8\u9ad3\u7ec6\u80de\u4e3a\u4f8b\u8bf4\u660e\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7f51\u7edc\u5728\u7406\u89e3\u57fa\u56e0\u7684\u4e0a\u4e0b\u6587\u7279\u5f02\u6027\u4f5c\u7528\u4e2d\u7684\u5e94\u7528\u3002\u9996\u5148\u7814\u7a76\u4e86\u5df2\u77e5\u7684\u5178\u578b\u7ec6\u80de\u578b\u7279\u5f81\u57fa\u56e0\u662f\u5426\u5728\u7f51\u7edc\u4e2d\u53d1\u6325\u7740\u72ec\u7279\u7684\u4f5c\u7528\uff0c\u7ed3\u679c\u8868\u660e\u8fd9\u4e9b\u6807\u5fd7\u6027\u57fa\u56e0\u5728\u76f8\u5e94\u7684\u7ec6\u80de\u4e9a\u7fa4\u4e2d\u8868\u73b0\u51fa\u663e\u8457\u66f4\u9ad8\u7684topS\u503c<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\uff0c\u5373\u63a8\u65ad\u7684\u5c40\u90e8\u4e92\u4f5c\u62d3\u6251\u7ed3\u6784\u6709\u6548\u6355\u6349\u4e86\u4e0e\u73af\u5883\u76f8\u5173\u7684\u751f\u7269\u5b66\u4f5c\u7528(\u56fe3A)\u3002\u6b64\u5916\u6839\u636e\u6bcf\u4e2a\u7ec6\u80de\u5b50\u96c6\u7684top\u548ctranS\u5206\u6570\u5206\u522b\u786e\u5b9a\u4e86\u524d500\u4e2a\u57fa\u56e0\uff0c\u5373\u4f7f\u5728\u8f6c\u5f55\u7279\u5f02\u6027\u548c\u62d3\u6251\u7279\u5f02\u6027\u5168\u5c40\u76f8\u5173\u7684\u60c5\u51b5\u4e0b\uff0ctopS\u548ctranS\u9274\u5b9a\u7684\u5019\u9009\u57fa\u56e0\u4e4b\u95f4\u4e5f\u5b58\u5728\u9002\u5ea6\u7684\u4e00\u81f4\u6027(\u56fe3B)\uff0c\u8868\u660e\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7f51\u7edc\u53ef\u4ee5\u8865\u5145\u4f20\u7edf\u7684\u8868\u8fbe\u5206\u6790\u3002<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u8fd8\u53d1\u73b0\u4e86\u51e0\u7ec4\u5728\u6bcf\u4e2a\u7ec6\u80de\u4e9a\u7fa4\u4e2d\u8868\u73b0\u51fa\u9ad8topS\u5f97\u5206\u4f46\u4f4etranS\u5f97\u5206\u7684\u57fa\u56e0(\u56fe3C)\uff0c\u5728\u591a\u4e2a\u7ec6\u80de\u4e9a\u7fa4\u4e2d\u8868\u8fbe\uff0c\u4f46\u5728\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7f51\u7edc\u4e2d\u5177\u6709\u4e0d\u540c\u7684\u62d3\u6251\u4f5c\u7528\u3002\u603b\u7684\u6765\u8bf4\uff0c\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7f51\u7edc\u4f7f\u6211\u4eec\u80fd\u591f\u7814\u7a76\u5728\u7ec6\u80de\u7c7b\u578b\u7f51\u7edc\u4e2d\u5177\u6709\u4f18\u5148\u5f71\u54cd\u4f5c\u7528\u7684\u57fa\u56e0\uff0c\u8fd9\u4e9b\u57fa\u56e0\u4e0d\u80fd\u5355\u72ec\u7528\u5b83\u4eec\u7684\u8868\u8fbe\u6a21\u5f0f\u6765\u89e3\u91ca\u3002<\/span><span style=\"font-size: 16px;\">    <\/span><\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010367\" data-ratio=\"0.5231481481481481\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_Z2KX2ibrPvmts4YF8N1gehOszpYXQg.png?resize=552%2C289\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQOjqicmKKBVpfjJeI0DdwSLLTE0ru2hIaYwaZmRMbEBF0WL3Z2KX2ibrPvmts4YF8N1gehOszpYXQg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"289 .27001953125\" width=\"552 .6799926757812\" data-recalc-dims=\"1\" \/><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010373\" data-ratio=\"0.4962962962962963\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-03_\u300c\u8f6c\u300d\u5988\u5988\u518d\u4e5f\u4e0d\u62c5\u5fc3\u6211\u7684\u5355\u7ec6\u80de\u5206\u6790\u4e86\uff0c\u70b9\u51fb\u5c31\u9001\u7684\u9006\u5929\u5916\u6302\uff01\u5929\u6d25\u533b\u79d1\u5927\u5b66\u6768\u626c\u56e2\u961f\u4e24\u4e2a\u6708\u63a5\u6536\u5230\u53d1\u8868\uff0c\u73a9\u51fa\u6df1\u5ea6\u5b66\u4e60\u65b0\u9ad8\u5ea6\uff01\/8_hD2a59sic7RWhcD6yNIwUZOvt1Ne7g.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQOjqicmKKBVpfjJeI0DdwSLtC7Hqve4z6aAQqGo5Sq1dibEEohD2a59sic7RWhcD6yNIwUZOvt1Ne7g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"274.5999755859375\" width=\"553.0800170898438\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">\u56fe3  \u6cdb\u80bf\u7624\u9aa8\u9ad3\u7ec6\u80de\u4e2d\u5177\u6709\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u5f71\u54cd\u7684\u62d3\u6251\u7279\u5f02\u6027\u57fa\u56e0<\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 0pt;text-indent: 0pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;letter-spacing: 1px;\">5.  \u901a\u8fc7\u7f51\u7edc\u8fde\u901a\u6027\u5206\u6790\u786e\u5b9a\u4e0e\u9884\u540e\u76f8\u5173\u7684\u7ec6\u80de\u7c7b\u578b<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u901a\u8fc7\u8bc4\u4f30\u75be\u75c5\u57fa\u56e0\u5728\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7f51\u7edc\u4e2d\u7684\u62d3\u6251\u7279\u6027\uff0c\u5c06\u75be\u75c5\u76f8\u5173\u57fa\u56e0\u96c6\u53cd\u5377\u79ef\u5230\u5355\u4e2a\u7ec6\u80de\u7c7b\u578b\u4e2d\u3002\u91c7\u7528\u6392\u5217\u68c0\u9a8c\u65b9\u6cd5\uff0c\u4ece\u7f51\u7edc\u4e2d\u53cd\u590d\u968f\u673a\u62bd\u6837\u76f8\u540c\u6570\u91cf\u7684\u57fa\u56e0\u4ea7\u751f\u96f6\u5206\u5e03\u3002\u6839\u636eTCGA\u4e34\u5e8a\u6570\u636e\u7684\u8868\u8fbe\u6c34\u5e73\u786e\u5b9a\u4e86\u524d500\u4e2a\u9884\u540e\u57fa\u56e0\u3002\u4f7f\u7528log-rank\u68c0\u9a8c\u7684\u8c03\u6574p\u503c\u5bf9\u8fd9\u4e9b<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u57fa\u56e0\u8fdb\u884c\u6392\u5e8f\u3002\u901a\u8fc7\u5bf9\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7f51\u7edc\u7684\u8fde\u901a\u6027\u5206\u6790\uff0c\u6211\u4eec\u53d1\u73b0\u9884\u540e\u57fa\u56e0\u5728\u975e\u764c\u7ec6\u80de(\u5305\u62ec\u57fa\u8d28\u7ec6\u80de\u548c\u514d\u75ab\u7ec6\u80de)\u4e2d\u5177\u6709\u5f88\u5f3a\u7684\u7f51\u7edc\u8fde\u901a\u6027(\u56fe4A)\uff0c\u8868\u660e\u4e00\u4e9b\u9884\u540e\u57fa\u56e0\u53ef\u80fd\u5728\u80bf\u7624\u5fae\u73af\u5883\u7684\u975e\u764c\u7ec6\u80de\u4e2d\u8d77\u4f5c\u7528\u3002   <\/span><\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u63a5\u4e0b\u6765\u4f5c\u8005\u91cd\u70b9\u7814\u7a76\u80c3\u764c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7279\u5f02\u6027\u4e92\u4f5c\u7ec4\u7f51\u7edc\u4e2d\u9884\u540e\u57fa\u56e0\u7684\u5f3a\u8fde\u901a\u6027\u3002\u5728\u6210\u7ea4\u7ef4\u7ec6\u80de\u7279\u5f02\u6027\u7f51\u7edc\u4e2d\u9274\u5b9a\u4e86128\u4e2a\u9876\u7ea7\u9884\u540e\u57fa\u56e0\uff0c\u5176\u4e2d78\u4e2a\u57fa\u56e0\u5f7c\u6b64\u7d27\u5bc6\u76f8\u8fde\uff0c\u6709\u51e0\u4e2a\u4e0e\u80bf\u7624\u8f6c\u79fb\u6269\u6563\u76f8\u5173\uff0c\u4e14\u5728\u6210\u7ea4\u7ef4\u7ec6\u80de\u7279\u5f02\u6027\u7f51\u7edc\u4e2d\u8868\u73b0\u51fa\u9ad8\u5ea6\u7684\u4e2d\u5fc3\u6027(\u56fe4B)\u3002\u68c0\u67e5\u4e86\u4e0e\u5176\u76f4\u63a5\u76f8\u8fde\u7684\u9876\u90e8\u67a2\u7ebd\u57fa\u56e0(\u56fe4C)\uff0c\u53d1\u73b0\u524d30\u4e2a\u76f4\u63a5\u90bb\u8fd1\u57fa\u56e0\u5728\u96cc\u6fc0\u7d20\u4fe1\u53f7\u901a\u8def\u548c\u5c40\u7076\u7c98\u9644\u4e2d\u5bcc\u96c6(\u56fe4D)\u3002\u4e0eITGB1\u76f4\u63a5\u76f8\u8fde\u7684\u51e0\u4e2a\u67a2\u7ebd\u57fa\u56e0EGFR\u3001FN1\u548cCOL1A1\uff0c\u5728\u6210\u7ea4\u7ef4\u7ec6\u80de\u7279\u5f02\u6027\u7f51\u7edc\u7684\u9884\u540e\u57fa\u56e0\u4e2d\u5177\u6709\u6700\u9ad8\u7684\u4e2d\u5fc3\u6027(\u56fe4E)\u3002\u6b64\u5916\uff0c\u5728TCGA-STAD\u6837\u672c\u4e2d\u89c2\u5bdf\u5230\u7684\u4e2d\u4f4d\u6570\u8868\u8fbe\u8bc1\u5b9e\u4e86ITGB1\u4e0e\u4e0d\u826f\u751f\u5b58\u7387\u7684\u5173\u8054(\u56fe4F)\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u63d0\u51faITGB1\u7684\u9884\u540e\u5f71\u54cd\u4e0eCAF\u4ecb\u5bfc\u7684\u80bf\u7624\u8fdb\u5c55\u6709\u5173\u3002<\/span><\/section>\n<section style=\"text-align: center;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010371\" data-ratio=\"0.687962962962963\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_UIGwNHjAouzS9fTV562ALZN1GFY1QA.png?resize=552%2C380\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQOjqicmKKBVpfjJeI0DdwSL1Bric1wz9KTbwgDLKRBUxzt6hUIGwNHjAouzS9fTV562ALZN1GFY1QA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"380 .1400146484375\" width=\"552 .5399780273438\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe4 <\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\"> \u80bf\u7624\u9884\u540e\u57fa\u56e0\u7279\u5f81\u7684\u7ec6\u80de\u578b\u53cd<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5377\u79ef<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 0pt;text-indent: 0pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;\">6.  \u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u4e92\u4f5c\u7ec4\u7f51\u7edc\u5728\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e2d\u7684\u5171\u6027\u548c\u5dee\u5f02<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u4f5c\u8005\u5bf9\u4e0d\u540c\u5b9e\u4f53\u7624\u7c7b\u578b\u7684\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u7279\u5f02\u6027\u7f51\u7edc\u8fdb\u884c\u6bd4\u8f83\u3002\u7ed3\u679c\u8868\u660e\uff0c\u7279\u5b9a\u4e8e\u76f8\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u7f51\u7edc\u59cb\u7ec8\u805a\u96c6\u5728\u4e00\u8d77\uff0c\u751a\u81f3\u8de8\u8d8a\u4e0d\u540c\u7684\u80bf\u7624\u7c7b\u578b\uff0c\u8fd9\u8868\u660e\u7ec6\u80de\u73af\u5883\u4e3b\u8981\u5851\u9020\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u4e92\u4f5c\u7ec4\u7f51\u7edc\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u4f5c\u8005\u68c0\u7d22\u5e76\u6bd4\u8f83\u4e86\u4e0d\u540c\u5b9e\u4f53\u80bf\u7624\u7c7b\u578b\u7684\u6076\u6027\u7ec6\u80de\u7279\u5f02\u6027\u7f51\u7edc\uff0c\u63ed\u793a\u4e0e\u5df2\u77e5\u6076\u6027\u80bf\u7624\u751f\u7406\u6761\u4ef6\u4e00\u81f4\u7684\u76f8\u5173\u5757(\u56fe5A)\u3002\u6076\u6027\u4e0a\u76ae\u80bf\u7624\u88ab\u53d1\u73b0\u805a\u96c6\u5728\u4e00\u8d77\uff0c\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e4b\u95f4\u51fa\u73b0\u4e86\u663e\u8457\u7684\u76f8\u5173\u5757\uff0c\u5e94\u7528\u7f51\u7edc\u7fa4\u843d\u68c0\u6d4b\u65b9\u6cd5Infomap\u8bc6\u522b\u4e86\u5bcc\u542b\u7cd6\u9175\u89e3\u3001\u4ee3\u8c22\u8fc7\u7a0b\u3001\u86cb\u767d\u8d28\u78f7\u9178\u5316\u3001MAPK\u4fe1\u53f7\u901a\u8def\u3001\u7ec6\u80de\u7c98\u9644\u548c\u708e\u75c7\u53cd\u5e94\u76f8\u5173\u529f\u80fd\u672f\u8bed\u7684\u6838\u5fc3\u5b50\u7f51\u7edc(\u56fe5B-E)\u3002\u603b\u7684\u6765\u8bf4\uff0c\u4ece\u6076\u6027\u7ec6\u80de\u7279\u6709\u7684\u5171\u4eab\u4e92\u4f5c\u7ec4\u4e2d\u786e\u5b9a\u7684\u6838\u5fc3\u5b50\u7f51\u7edc\u53ef\u4ee5\u63d0\u4f9b\u5bf9\u5019\u9009\u80bf\u7624\u57fa\u56e0\u7684\u89c1\u89e3\uff0c\u5e76\u4ea7\u751f\u53ef\u6d4b\u8bd5\u7684\u5047\u8bbe\u3002<\/span><\/section>\n<section style=\"text-align: center;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010374\" data-ratio=\"0.6182495344506518\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-03_\u300c\u8f6c\u300d\u5988\u5988\u518d\u4e5f\u4e0d\u62c5\u5fc3\u6211\u7684\u5355\u7ec6\u80de\u5206\u6790\u4e86\uff0c\u70b9\u51fb\u5c31\u9001\u7684\u9006\u5929\u5916\u6302\uff01\u5929\u6d25\u533b\u79d1\u5927\u5b66\u6768\u626c\u56e2\u961f\u4e24\u4e2a\u6708\u63a5\u6536\u5230\u53d1\u8868\uff0c\u73a9\u51fa\u6df1\u5ea6\u5b66\u4e60\u65b0\u9ad8\u5ea6\uff01\/10_IZLp13wtLSQLeIia8461GMaiby6SDg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQOjqicmKKBVpfjJeI0DdwSL5WtNC4BMSGYhBmeEsqx8veWBlnIZLp13wtLSQLeIia8461GMaiby6SDg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1074\" height=\"341.94000244140625\" width=\"553.1400146484375\" \/><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010375\" data-ratio=\"0.44018691588785047\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_tEvVtict9ct4vibX91YDhkczZ9FvXg.png?resize=553%2C243\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQOjqicmKKBVpfjJeI0DdwSLDxsCghEDaISSsqLOMY3ia1A4Id6tEvVtict9ct4vibX91YDhkczZ9FvXg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1070\" height=\"243 .53997802734375\" width=\"553 .2100219726562\" data-recalc-dims=\"1\" \/><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010372\" data-ratio=\"0.4304388422035481\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-03_\u300c\u8f6c\u300d\u5988\u5988\u518d\u4e5f\u4e0d\u62c5\u5fc3\u6211\u7684\u5355\u7ec6\u80de\u5206\u6790\u4e86\uff0c\u70b9\u51fb\u5c31\u9001\u7684\u9006\u5929\u5916\u6302\uff01\u5929\u6d25\u533b\u79d1\u5927\u5b66\u6768\u626c\u56e2\u961f\u4e24\u4e2a\u6708\u63a5\u6536\u5230\u53d1\u8868\uff0c\u73a9\u51fa\u6df1\u5ea6\u5b66\u4e60\u65b0\u9ad8\u5ea6\uff01\/12_btYL7qy6DDpTlYFvib4Z349TfQq9rQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQOjqicmKKBVpfjJeI0DdwSLCqgoyIf7jykqFcET5j2x1gycXibtYL7qy6DDpTlYFvib4Z349TfQq9rQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1071\" height=\"238.3399658203125\" width=\"553.739990234375\" \/><\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe5 <\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\"> \u4e0d\u540c\u80bf\u7624\u6076\u6027\u7ec6\u80de\u7279\u5f02\u6027<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4e92\u4f5c\u7ec4\u7f51\u7edc\u7684\u6bd4\u8f83\u5206\u6790<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 0pt;text-indent: 0pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;letter-spacing: 1px;\">7.  \u98ce\u9669\u57fa\u56e0\u6392\u5e8f\u7684\u5e94\u7528<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u8fdb\u884c\u57fa\u51c6\u5206\u6790\uff0c\u8bc4\u4f30\u56db\u79cd\u4ee3\u8868\u6027\u65b9\u6cd5rwr\u3001GenePanda\u3001Node2Vec\u548cDIAMOnD\u7684\u6027\u80fd\u3002\u5229\u7528\u764c\u75c7\u57fa\u56e0\u666e\u67e5(CGC)\u4e2d\u6ce8\u91ca\u7684\u57fa\u56e0\u4f5c\u4e3a\u79cd\u5b50\u57fa\u56e0\uff0c\u7528\u6765\u81ea6\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u7684\u6076\u6027\u7ec6\u80de\u7279\u5f02\u6027\u7f51\u7edc\u5bf9\u98ce\u9669\u57fa\u56e0\u8fdb\u884c\u4f18\u5148\u6392\u5e8f\u3002\u4ee5NCG 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Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">\u6b64\u5916\uff0c\u7528\u6237\u53ef\u4ee5\u4f7f\u7528\u9488\u5bf9\u4e0d\u540c\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u7684\u4e92\u4f5c\u7ec4\u7f51\u7edc\u6765\u786e\u5b9a\u98ce\u9669\u57fa\u56e0\u7684\u4f18\u5148\u7ea7\u3002\u4f8b\u5982\u8f93\u5165\u4e0eT\u7ec6\u80de\u8017\u7aed\u76f8\u5173\u7684\u57fa\u56e0\u5217\u8868\u4f5c\u4e3a\u79cd\u5b50\u57fa\u56e0\uff0c\u5c06\u8fd4\u56de\u4f7f\u7528CD8+\u8017\u7aedT\u7ec6\u80de\u7279\u5f02\u6027\u7f51\u7edc\u4f18\u5148\u6392\u5e8f\u7684\u5019\u9009\u57fa\u56e0\u5217\u8868(\u56fe6C)\u3002\u4e3a\u4e86\u9a8c\u8bc1\u5176\u4ed6\u6392\u540d\u6700\u9ad8\u7684\u5019\u9009\u57fa\u56e0\uff0c\u6211\u4eec\u6536\u96c6\u4e866\u4e2aICB\u6cbb\u7597\u76f8\u5173\u7684\u961f\u5217\uff0c\u5bf9\u6bd4\u5206\u6790\u663e\u793a\u57fa\u4e8e\u60a3\u8005\u5bf9ICB\u6cbb\u7597\u7684\u53cd\u5e94\uff0c\u51e0\u4e2a\u6392\u540d\u9760\u524d\u7684\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\u5728\u60a3\u8005\u4e4b\u95f4\u5b58\u5728\u5dee\u5f02(\u56fe6D-F)\u3002\u4f8b\u5982\u672a\u53cd\u5e94\u7ec4\u9884\u5904\u7406\u60a3\u8005\u7684KLRD1\u57fa\u56e0\u660e\u663e\u4e0b\u8c03\uff1b\u5728\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(PFS)\u548c\u603b\u751f\u5b58\u671f(OS)\u65b9\u9762\uff0cKLRD1\u3001CD27\u548cLAGLAS9\u7684\u9ad8\u8868\u8fbe\u7ec4\u660e\u663e\u4f18\u4e8e\u4f4e\u8868\u8fbe\u7ec4(\u56fe6G-L)\uff0c\u8868\u660e\u4f18\u5148\u7ea7\u5206\u6790\u4e2d\u6392\u540d\u9760\u524d\u7684\u57fa\u56e0\u53ef\u80fd\u4e0eT\u7ec6\u80de\u8870\u7aed\u6709\u5173\uff0c\u53ef\u80fd\u5f71\u54cdICB\u6cbb\u7597\u7684\u6709\u6548\u6027\u3002\u7efc\u4e0a\u4e0d\u540c\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u7279\u5f02\u6027\u7684\u4e92\u4f5c\u7ec4\u7f51\u7edc\u53ef\u80fd\u662f\u786e\u5b9a\u53c2\u4e0e\u764c\u75c7\u514d\u75ab\u7684\u91cd\u8981\u57fa\u56e0\u4f18\u5148\u7ea7\u7684\u5b9d\u8d35\u8d44\u6e90\u3002<\/span><\/section>\n<section style=\"text-align: center;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010378\" data-ratio=\"0.5074074074074074\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_JfibhI25RCe3e0IrLF6etxnsFDELPA.png?resize=553%2C280\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQOjqicmKKBVpfjJeI0DdwSLXwI2PWxGlru9fEf4RZBtbialCbJfibhI25RCe3e0IrLF6etxnsFDELPA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"280 .739990234375\" width=\"553 .6099853515625\" data-recalc-dims=\"1\" \/><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010377\" data-ratio=\"0.36944444444444446\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-03_\u300c\u8f6c\u300d\u5988\u5988\u518d\u4e5f\u4e0d\u62c5\u5fc3\u6211\u7684\u5355\u7ec6\u80de\u5206\u6790\u4e86\uff0c\u70b9\u51fb\u5c31\u9001\u7684\u9006\u5929\u5916\u6302\uff01\u5929\u6d25\u533b\u79d1\u5927\u5b66\u6768\u626c\u56e2\u961f\u4e24\u4e2a\u6708\u63a5\u6536\u5230\u53d1\u8868\uff0c\u73a9\u51fa\u6df1\u5ea6\u5b66\u4e60\u65b0\u9ad8\u5ea6\uff01\/14_kMLhd6qzQb1kLFmJeibyiaIOvYTb0g.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQOjqicmKKBVpfjJeI0DdwSLbJkKwAKflueUTxY5b0LL0zITf2kMLhd6qzQb1kLFmJeibyiaIOvYTb0g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"204.39996337890625\" width=\"553.6099853515625\" \/><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010376\" data-ratio=\"0.5101851851851852\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/15_xswvRaVgLbHOux24oMw2ujx9Pr6b2w.png?resize=553%2C282\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQOjqicmKKBVpfjJeI0DdwSLwa0xH8NBtahh38YnAV7wxjT0xswvRaVgLbHOux24oMw2ujx9Pr6b2w\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"282 .20001220703125\" width=\"553 .2100219726562\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe6 <\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\"> \u5728CellNetdb\u4e2d\u5bf9\u98ce\u9669\u57fa\u56e0\u8fdb\u884c\u4f18\u5148\u6392\u5e8f<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><span style=\"font-size: 16px;text-indent: 0pt;letter-spacing: 1px;\">         <\/span><o:p style=\"font-size: 16px;letter-spacing: 1px;text-indent: 0pt;\"><span style=\"letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u602a\u4e0d\u5f97\u4e24\u4e2a\u6708\u5c31\u80fd\u83b7\u5f97\u8bc4\u5ba1\u7684\u9752\u7750\uff0c\u6570\u636e\u5728\u624b\u7528\u4e0aCellNetdb\u7b80\u76f4\u662f\u7248\u672cT0\u4e86\u5440\uff01\u8fd9\u6837\u7684\u5916\u6302\u8fd8\u662f\u516c\u5171\u5e73\u53f0\uff0c\u5fc3\u52a8\u5c31\u8d76\u7d27\u7528\u8d77\u6765\u5427\u3002\u5c0f\u9014\u4e3a\u5927\u5bb6\u63a8\u8350\u7684\u5de5\u5177\u6216\u5e73\u53f0\u82e5\u662f\u52a9\u4f60SCI\u529f\u6210\uff0c\u53ef\u8981\u6765\u548c\u5c0f\u9014\u62a5\u559c\u54df\uff01\u8bf4\u4e0d\u5b9a\u5c0f\u9014\u4e0b\u4e00\u7bc7\u5c31\u8981\u5411\u5927\u5bb6\u63a8\u9001\u4f60\u7684\u6587\u7ae0\u54e6\uff01<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(255, 0, 0);font-weight: bold;text-decoration: underline;background: rgb(255, 255, 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1px;\">\u5982\u679c\u4f60\u8fd8\u82e6\u607c\u4e8e\u751f\u4fe1\u5206\u6790\u6ca1\u6709\u601d\u8def\uff0c\u6216\u8005\u5acc\u5206\u6790\u65b9\u6cd5\u592a\u8fc7\u7b80\u5355\u3001\u592a\u8fc7\u8001\u5957\uff0c\u60f3\u8981\u521b\u65b0\u601d\u8def\u7684\uff0c\u6216\u8005\u5bf9\u5355\u7ec6\u80de\u5206\u6790\u3001\u591a\u7ec4\u5b66\u8054\u5408\u5206\u6790\u7b49\u65b9\u5411\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u5feb\u6765\u8054\u7cfb\u5c0f\u9014\u5427\uff01<\/span><\/section>\n<section style=\"text-indent: 0px;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"color: rgb(0, 122, 170);letter-spacing: 1px;\"><strong><span style=\"color: rgb(0, 122, 170);text-indent: 32px;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100017513\" data-ratio=\"0.7621359223300971\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-03_\u300c\u8f6c\u300d\u5988\u5988\u518d\u4e5f\u4e0d\u62c5\u5fc3\u6211\u7684\u5355\u7ec6\u80de\u5206\u6790\u4e86\uff0c\u70b9\u51fb\u5c31\u9001\u7684\u9006\u5929\u5916\u6302\uff01\u5929\u6d25\u533b\u79d1\u5927\u5b66\u6768\u626c\u56e2\u961f\u4e24\u4e2a\u6708\u63a5\u6536\u5230\u53d1\u8868\uff0c\u73a9\u51fa\u6df1\u5ea6\u5b66\u4e60\u65b0\u9ad8\u5ea6\uff01\/16_XiafCUEp1NqZoBA3F9mvRcJR4PQ1Tw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAyZkFgOs95yxYHqY7n8a8k4wWKhXgwQvZVTwDhgYYDDu7asGXiafCUEp1NqZoBA3F9mvRcJR4PQ1Tw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"618\" style=\"\" \/><\/section>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017759\" data-ratio=\"1\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-03_\u300c\u8f6c\u300d\u5988\u5988\u518d\u4e5f\u4e0d\u62c5\u5fc3\u6211\u7684\u5355\u7ec6\u80de\u5206\u6790\u4e86\uff0c\u70b9\u51fb\u5c31\u9001\u7684\u9006\u5929\u5916\u6302\uff01\u5929\u6d25\u533b\u79d1\u5927\u5b66\u6768\u626c\u56e2\u961f\u4e24\u4e2a\u6708\u63a5\u6536\u5230\u53d1\u8868\uff0c\u73a9\u51fa\u6df1\u5ea6\u5b66\u4e60\u65b0\u9ad8\u5ea6\uff01\/3_B2jkicacLzPjw4xMSqVvoucZjonVDA.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'&from=appmsg\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><span style=\"letter-spacing: 1px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n<p style=\"margin-bottom: 2px;\"><span style=\"letter-spacing: 1px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n<p><span style=\"letter-spacing: 1px;\"><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><br \/><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span style=\"letter-spacing: 1px;\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017761\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/18_7TvAyUibd1TPhJmZfialJtv6tu2SEg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\"><\/span><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><br \/><\/section>\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><span style=\"letter-spacing: 1px;\"><strong>\u5f80\u671f\u56de\u987e<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"letter-spacing: 1px;\"><strong>01<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);letter-spacing: 1px;\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"letter-spacing: 1px;\"><strong>02<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);letter-spacing: 1px;\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"letter-spacing: 1px;\"><strong>03<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);letter-spacing: 1px;\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"letter-spacing: 1px;\"><strong>04<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);letter-spacing: 1px;\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" 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