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16px;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.5px;line-height: 2em;font-family: \u5b8b\u4f53;\"><br  \/><\/span><\/p>\n<p style=\"font-size: 16px;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.5px;line-height: 2em;font-family: \u5b8b\u4f53;\">\u8fd9\u6837\u770b\u6765\uff0c\u9884\u6d4b\u662f\u5f88\u91cd\u8981\u7684\uff0c\u90a3\u4e48\u95ee\u9898\u6765\u4e86\uff0c\u8be5\u5982\u4f55\u9884\u6d4b\u5462\uff1f<\/span><span style=\"text-decoration: underline;font-size: 14px;letter-spacing: 0.5px;line-height: 2em;font-family: \u5b8b\u4f53;\">TIDE\u548cGenePattern\u7f51\u7ad9\u7684submap\u7b97\u6cd5\u63d0\u4f9b\u4e86\u9884\u6d4b\u9014\u5f84\uff0c\u751f\u4fe1\u4e91\u5e73\u53f0\u636e\u6b64\u63d0\u4f9b\u4e86\u7ebf\u4e0a\u5de5\u5177\u3002<\/span><span style=\"font-size: 14px;letter-spacing: 0.5px;caret-color: red;font-family: 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\u5b8b\u4f53;\">\u52063\u6b65\u5c55\u793a\uff0c\u540e\u7eed\u5185\u5bb9\u8bf7\u6301\u7eed\u5173\u6ce8\u54e6\uff01\uff09\uff1a<\/span><\/p>\n<p style=\"font-size: 16px;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.5px;line-height: 2em;font-family: \u5b8b\u4f53;\"><br  \/><\/span><\/p>\n<section data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"98902\" data-width=\"100%\" style=\"font-size: 16px;letter-spacing: 0.578px;margin-right: auto;margin-bottom: 0px;margin-left: auto;white-space: normal;caret-color: rgba(0, 0, 0, 0);width: 553.785px;flex: 0 0 100%;\">\n<section data-role=\"layout\" style=\"display: flex;justify-content: center;flex-flow: row nowrap;\">\n<section data-role=\"layout\" data-width=\"20%\" style=\"max-width: 20%;display: inline-block;width: 110.747px;\">\n<section data-role=\"layout-inner\">\n<section data-role=\"paragraph\">\n<p style=\"text-align: center;text-indent: 0em;line-height: 1.75em;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-05-29_\u5c0f\u679c\u7684\u5355\u65e5\u5c0f\u6280\u5de7DAY3\uff1a\u9884\u6d4b\u67d0\u6837\u672c\u4e9a\u578b\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u54cd\u5e94step1\/2_4ibibjQVKaEZjgDcujdk3rDWoVe2Mg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyrricjRoBoPO5X3NaJyYDObEAcutrgHOCplUfVqOfv1WB6XGm4ibibjQVKaEZjgDcujdk3rDWoVe2Mg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"500\" data-width=\"79px\" title=\"\u5fae\u4fe1\u56fe\u7247_20230506104258.png\" width=\"79px\" style=\"vertical-align: inherit;letter-spacing: 0.578px;width: 79px;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-bottom: 0px;white-space: normal;caret-color: rgba(0, 0, 0, 0);\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;display: flex;flex-flow: row nowrap;text-align: center;justify-content: center;\">\n<section style=\"padding-right: 12px;padding-left: 12px;display: inline-block;vertical-align: bottom;width: auto;border-bottom: 0px solid rgb(169, 207, 245);border-bottom-right-radius: 0px;flex: 0 0 auto;align-self: flex-end;min-width: 10%;height: auto;\">\n<section style=\"margin-bottom: -3px;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-indent: 0em;line-height: 1.75em;\"><span style=\"font-size: 20px;letter-spacing: 0.5px;\"><strong><em>\u98df\u7528\u6b65\u9aa4<\/em><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"98902\" data-width=\"100%\" style=\"font-size: 16px;letter-spacing: 0.578px;margin-right: auto;margin-bottom: 0px;margin-left: auto;white-space: normal;width: 512.778px;flex: 0 0 100%;\">\n<section data-role=\"layout\" style=\"display: flex;justify-content: center;flex-flow: row nowrap;\">\n<section data-role=\"layout\" data-width=\"20%\" style=\"max-width: 20%;display: inline-block;width: 102.552px;\">\n<section data-role=\"layout-inner\">\n<section data-role=\"paragraph\">\n<p style=\"text-align: center;text-indent: 0em;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"font-size: 16px;letter-spacing: 0.578px;margin-bottom: 24px;\">\n<section style=\"margin-bottom: 8px;\"><span style=\"font-size: 14px;letter-spacing: 0.5px;line-height: 2em;font-family: \u5b8b\u4f53;\">Step1\uff1aRscript preTIDE.R \u4e9a\u578b\u8f6c\u5f55\u7ec4\u6570\u636e\u8fdb\u884c\u6807\u51c6\u5316\u3002<\/span><\/section>\n<p><span style=\"font-size: 14px;letter-spacing: 0.5px;line-height: 2em;font-family: \u5b8b\u4f53;\">Step2\uff1aRscript readTIDE.R \u8868\u578b\u6587\u4ef6 TIDE\u8f93\u51fa \u6837\u672c\u8f6c\u5f55\u7ec4 \u6837\u672c\u4fe1\u606f TCGA\u4e2d\u8be5\u7c7b\u764c\u75c7\u5168\u90e8\u6837\u672c\u8f6c\u5f55\u7ec4\u6570\u636e\uff08\u5254\u9664\u4f4e\u8868\u8fbe\uff09<\/span><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.5px;line-height: 2em;font-family: \u5b8b\u4f53;\">Step3: Rscript readsubmap.R submap\u7f51\u7ad9\u5f97\u5230\u7684\u77e9\u9635\u4e2d\u768416\u4e2apvalu<\/span><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><section style=\"margin-bottom: 8px;\"><code><span class=\"code-snippet_outer\">\u3010\u540e\u53f0\u4f7f\u7528\u65b9\u6cd5\u3011<\/span><\/code><code><span class=\"code-snippet_outer\">\/media\/desk16\/zhl\/miniconda3\/envs\/bio\/bin\/Rscript<\/span><\/code><code><span class=\"code-snippet_outer\">\/media\/desk16\/zhl\/tools\/zhl106TIDE\/example_and_coad\/preTIDE.R<\/span><\/code><code><span class=\"code-snippet_outer\">\/media\/desk16\/zhl\/tools\/zhl106TIDE\/example_and_coad\/easy_input_expr.txt<\/span><\/code><\/section><\/pre>\n<\/section>\n<section style=\"font-size: 16px;letter-spacing: 0.578px;margin-bottom: 8px;\"><br  \/><\/section>\n<section data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"98902\" data-width=\"100%\" style=\"margin-right: auto;margin-bottom: 0px;margin-left: auto;letter-spacing: 0.578px;white-space: normal;caret-color: rgba(0, 0, 0, 0);font-size: 16px;width: 553.785px;flex: 0 0 100%;\">\n<section data-role=\"layout\" style=\"display: flex;justify-content: center;flex-flow: row nowrap;\">\n<section data-role=\"layout\" data-width=\"20%\" style=\"max-width: 20%;display: inline-block;width: 110.747px;\">\n<section data-role=\"layout-inner\">\n<section data-role=\"paragraph\">\n<section data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"98902\" data-width=\"100%\" style=\"margin-right: auto;margin-bottom: 0px;margin-left: auto;letter-spacing: 0.578px;white-space: normal;caret-color: rgba(0, 0, 0, 0);width: 553.785px;flex: 0 0 100%;\">\n<section data-role=\"layout\" style=\"display: flex;justify-content: center;flex-flow: row nowrap;\">\n<section data-role=\"layout\" data-width=\"20%\" style=\"max-width: 20%;display: inline-block;width: 110.747px;\">\n<section data-role=\"layout-inner\">\n<section data-role=\"paragraph\">\n<p style=\"text-align: center;text-indent: 0em;line-height: 1.75em;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_PQnhYGbWksh8gWWibicbpWPgfD96HQ.png?w=79\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyrricjRoBoPO5X3NaJyYDObtehYNWkEzumKs140Mxk7jBibWRuPQnhYGbWksh8gWWibicbpWPgfD96HQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"500\" data-width=\"79px\" style=\"vertical-align: inherit;width: 79px;\" title=\"2.png\"  data-recalc-dims=\"1\" \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;letter-spacing: 0.578px;white-space: normal;caret-color: rgba(0, 0, 0, 0);display: flex;flex-flow: row nowrap;justify-content: center;\">\n<section style=\"padding-right: 12px;padding-left: 12px;display: inline-block;vertical-align: bottom;width: auto;border-bottom: 0px solid rgb(169, 207, 245);border-bottom-right-radius: 0px;flex: 0 0 auto;align-self: flex-end;min-width: 10%;height: auto;\">\n<section style=\"margin-bottom: -3px;\">\n<section>\n<p style=\"text-indent: 0em;line-height: 1.75em;\"><span style=\"font-size: 20px;letter-spacing: 0.5px;\"><strong><em>\u5f00\u52a8\u5566<\/em><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"font-size: 16px;letter-spacing: 0.578px;margin-bottom: 8px;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\">\n<section style=\"padding-right: 5px;display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;line-height: 0;\">\n<section style=\"transform-style: flat;transform: perspective(0px);\">\n<section style=\"text-align: center;line-height: 0;transform: rotateY(180deg);\"><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"font-size: 16px;letter-spacing: 0.578px;margin-bottom: 24px;\">\n<section style=\"margin-bottom: 8px;\"><span style=\"font-size: 14px;letter-spacing: 0.5px;line-height: 2em;font-family: \u5b8b\u4f53;\">1. \u70b9\u51fb\u4e0a\u4f20\u6570\u636e \u8f93\u51651\u4e2a\u6587\u4ef6\uff0c\u8f93\u5165\u7684\u6587\u4ef6\u540d\u5fc5\u987b\u548c\u793a\u4f8b\u6587\u4ef6\u540d\u4e00\u81f4\uff0c\u4e14\u90fd\u662f\u82f1\u6587\u65e0\u7279\u6b8a\u5b57\u7b26\u3002\u5982\u679c\u4f7f\u7528\u81ea\u6709\u6570\u636e\u65f6\uff0c\u9700\u6ce8\u610f\u6587\u4ef6\u540d\u548c\u5bf9\u5e94\u7684\u5185\u5bb9\u8981\u5339\u914d\uff0c\u4ee5\u53ca\u8f93\u5165\u6570\u636e\u91cc\u7684\u884c\u540d\u5217\u540d\u7b49\u7b49\u3002<\/span><\/section>\n<p><span style=\"font-size: 14px;letter-spacing: 0.5px;line-height: 2em;font-family: \u5b8b\u4f53;\">2. \u5982\u6709\u975e\u6587\u4ef6\u7c7b\u53c2\u6570\uff0c\u70b9\u51fb \u8f93\u5165\u53c2\u6570\u5bf9\u5e94\u7684\u503c,\u9ed8\u8ba4\u6bd4\u5982 pvalue\u503c\u662f0.05 gene\u503c\u662f TP53&nbsp;&nbsp;<\/span><\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"c\"><code><span class=\"code-snippet_outer\">\u3010\u8f93\u5165\u6587\u4ef6\u540d\u3011\u8f93\u5165\u6587\u4ef6\u540d<span class=\"code-snippet__number\">1<\/span>\uff1aeasy_input_expr.txt\u8f93\u5165\u5176\u4ed6\u53c2\u6570\uff1a\u65e0\u8f93\u5165\u6587\u4ef6\u5c55\u793a\uff08\u8fd9\u662f\u81eatcga\u4e0b\u8f7d\u7684\u764c\u75c7\u4e9a\u578b\u8f6c\u5f55\u7ec4\u77e9\u9635\uff0c\u8ba1\u6570\u65b9\u5f0f\u4e3a\u5bf9\u6570\u578b\u751f\u6210\u6587\u4ef6\u5c55\u793a\uff09easy_input_expr.txt<\/span><\/code><code><span class=\"code-snippet_outer\"><br  \/><\/span><\/code><\/pre>\n<\/section>\n<section style=\"font-size: 16px;letter-spacing: 0.578px;margin-bottom: 24px;\">\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.4581066376496192\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-05-29_\u5c0f\u679c\u7684\u5355\u65e5\u5c0f\u6280\u5de7DAY3\uff1a\u9884\u6d4b\u67d0\u6837\u672c\u4e9a\u578b\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u54cd\u5e94step1\/4_XJEZNUUbuCFl7UzL6I8OicBnRrH5gA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyOGTfECk54eObZ086MzWibQBjXk2kgAibxoShOzpqXT1KSyNrXJEZNUUbuCFl7UzL6I8OicBnRrH5gA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"919\" style=\"width: 100%;\"><\/p>\n<section style=\"margin-bottom: 8px;\"><br  \/><\/section>\n<section style=\"margin-bottom: 8px;\"><span style=\"font-size: 14px;letter-spacing: 0.5px;line-height: 2em;font-family: \u5b8b\u4f53;\">\u672c\u7a0b\u5e8f\u5bf9\u6570\u636e\u7684\u884c\u4e0e\u5217\u90fd\u8fdb\u884c\u4e86\u6807\u51c6\u5316\uff0c\u4f46\u5e76\u672a\u4e2d\u5fc3\u5316\u3002<\/span><\/section>\n<p><strong><span style=\"font-size: 14px;letter-spacing: 0.5px;line-height: 2em;font-family: \u5b8b\u4f53;text-decoration: none;\">\u793a\u4f8b\u7a0b\u5e8f\u8017\u65f6\uff1a\u77ac\u95f4\u5b8c\u6210<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.5307692307692308\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_kXqfDpObIW4vXpAhpbY6dL9OnBUVsQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyOGTfECk54eObZ086MzWibQJTA32zpPH6pzmqibtYiaR35cFJkXqfDpObIW4vXpAhpbY6dL9OnBUVsQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"910\" style=\"width: 100%;\" data-recalc-dims=\"1\"><\/p>\n<section style=\"margin-bottom: 8px;\"><span style=\"font-size: 14px;letter-spacing: 0.5px;line-height: 2em;font-family: \u5b8b\u4f53;\">\u5440\uff01\u8fd8\u6ca1\u5403\u9971\uff0c\u4e0b\u671f\u7ee7\u7eed~<\/span><\/section>\n<\/section>\n<p style=\"font-size: 16px;letter-spacing: 0.578px;\"><span style=\"letter-spacing: 0.5px;line-height: 1.75em;\">\u6b22\u8fce\u4f7f\u7528\uff1a<\/span><span style=\"letter-spacing: 0.5px;line-height: 1.75em;\"><em><strong>\u4e91\u751f\u4fe1&nbsp;&nbsp;&#8211;&nbsp;\u5b66\u751f\u7269\u4fe1\u606f\u5b66&nbsp;(biocloudservice.com)-\u6587\u672b\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u53ef\u4ee5\u8df3\u8f6c<\/strong><\/em><\/span><span style=\"letter-spacing: 0.578px;\"><\/span><\/p>\n<section data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"105054\" style=\"font-size: 16px;letter-spacing: 0.578px;\">\n<section style=\"margin: 10px auto;text-align: center;\">\n<section style=\"padding-top: 30px;padding-bottom: 30px;background-color: rgb(242, 246, 255);border-radius: 7px;\">\n<section style=\"display: flex;justify-content: space-evenly;align-items: center;\">\n<section data-width=\"26%\" style=\"width: 26%;\">\n<section style=\"padding: 7px;border-radius: 15px;box-shadow: rgba(169, 187, 223, 0.45) 4px 4px 8px, rgb(255, 255, 255) -2.5px -2.5px 5px;\">\n<section data-width=\"100%\" style=\"width: 100%;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.005281690140845\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-05-29_\u5c0f\u679c\u7684\u5355\u65e5\u5c0f\u6280\u5de7DAY3\uff1a\u9884\u6d4b\u67d0\u6837\u672c\u4e9a\u578b\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u54cd\u5e94step1\/6_zItfwjCtWicic31FZcrbRTd5r3ib6Q.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyrricjRoBoPO5X3NaJyYDObnuiaubWCb5M16S8cARfjeLm2Oh7GzItfwjCtWicic31FZcrbRTd5r3ib6Q\/640?wx_fmt=other'\" data-type=\"png\" data-w=\"568\" data-width=\"100%\" style=\"vertical-align: inherit;width: 100%;display: block;border-radius: 7px;\" title=\"\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801.png\"><\/section>\n<\/section>\n<\/section>\n<section data-width=\"62%\" style=\"width: 62%;\">\n<section style=\"display: inline-block;\">\n<section style=\"padding: 7px 15px;border-radius: 20px;box-shadow: rgba(169, 187, 223, 0.45) 6px 6px 8px inset, rgb(255, 255, 255) -2.5px -2.5px 5px inset;\">\n<section data-brushtype=\"text\" style=\"font-size: 14px;letter-spacing: 1.5px;color: rgb(111, 133, 172);\">\n<p style=\"text-indent: 0em;line-height: 1.75em;\"><span style=\"letter-spacing: 0.5px;\">\u5fae\u4fe1\u53f7 | 18502195490<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-top: 12px;padding: 7px 15px;border-radius: 20px;box-shadow: rgba(169, 187, 223, 0.45) 6px 6px 8px inset, rgb(255, 255, 255) -2.5px -2.5px 5px inset;\">\n<section data-brushtype=\"text\" style=\"font-size: 14px;letter-spacing: 1.5px;color: rgb(111, 133, 172);\">\n<p style=\"text-indent: 0em;line-height: 1.75em;\"><span style=\"letter-spacing: 0.5px;\">\u77e5\u4e4e | \u751f\u4fe1\u679c<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-bottom: 0px;letter-spacing: 0.578px;font-size: 16px;\">\n<section>\n<section style=\"margin-top: 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