{"id":56493,"date":"2024-06-16T17:58:38","date_gmt":"2024-06-16T09:58:38","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=56493"},"modified":"2024-06-16T17:58:38","modified_gmt":"2024-06-16T09:58:38","slug":"nature-communication%ef%bc%81%e5%9b%bd%e8%87%aa%e7%84%b6top%e7%ba%a7%e7%83%ad%e7%82%b9%ef%bc%81%e5%8d%95%e7%bb%86%e8%83%9e%e5%b7%a8%e5%99%ac%e7%bb%86%e8%83%9e%e8%a1%a8%e8%a7%82%e9%81%97%e4%bc%a0","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=56493","title":{"rendered":"Nature Communication\uff01\u56fd\u81ea\u7136TOP\u7ea7\u70ed\u70b9\uff01\u5355\u7ec6\u80de+\u5de8\u566c\u7ec6\u80de+\u8868\u89c2\u9057\u4f20\u9a71\u52a8\uff0c\u590d\u65e6\u5927\u5b66\u56e2\u961f\uff0c\u8fd9\u8bbe\u8ba1\u601d\u8def\u62c9\u6ee1\u4e86\u5440\uff01"},"content":{"rendered":"


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style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u201c\u5de8\u566c\u7ec6\u80de\u201d\uff0c\u201c\u8868\u89c2\u9057\u4f20\u201d\u4e00\u76f4\u662f\u8fd1\u51e0\u5e74\u7533\u8bf7\u56fd\u81ea\u7136\u65b9\u5411\u4e2dtop\u7ea7\u522b\u7684\u70ed\u70b9\uff0c\u4e2d\u6807\u6570\u91cf\u5c45\u9ad8\u4e0d\u4e0b\u3002<\/span><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u8fd9\u4e0d\u4eca\u5929\uff0c\u9986\u957f\u7ed9\u5927\u5bb6\u5e26\u6765\u4e86\u521a\u521a\u5728\u4eca\u5e743\u6708\u53d1\u8868\u7684\u7531\u590d\u65e6\u5927\u5b66Lu Wei\u56e2\u961f\u5728Nature Communication\u53d1\u8868\u7684\u4e00\u7bc7\u5173\u4e8em6a\u8868\u89c2\u9057\u4f20\u4fee\u9970\u9a71\u52a8\u4e0b\u7684\u5173\u4e8e\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u8c03\u8282\u5fc3\u810f\u7ea4\u7ef4\u5316\u7684\u6587\u7ae0\u3002\u6b64\u7bc7\u6587\u7ae0\uff0c<\/span><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u5b9e\u9a8c\u8bbe\u8ba1\u4e25\u4e1d\u5408\u7f1d\u3001\u903b\u8f91\u7f1c\u5bc6\uff0c\u590d\u6742\u5ea6\u548c\u521b\u65b0\u5ea6<\/span><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4e5f\u505a\u5230\u4e86\u517c\u987e\uff1a<\/span><\/span><\/section>\n<section style=\"text-indent: 12pt;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">1.<\/span><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u7684\u5e94\u7528\uff1a<\/span><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u672c\u7814\u7a76\u901a\u8fc7\u4f7f\u7528\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u6280\u672f\uff0c\u6df1\u5165\u5206\u6790\u4e86\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u5728\u9ad8\u8840\u538b\u6761\u4ef6\u4e0b\u7684\u5f02\u8d28\u6027\u548c\u52a8\u6001\u53d8\u5316\u3002\u8fd9\u79cd\u9ad8\u5206\u8fa8\u7387\u7684\u7ec6\u80de\u8868\u578b\u5206\u6790\u6280\u672f\u4e3a\u7406\u89e3\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u7684\u590d\u6742\u6027\u548c\u529f\u80fd\u591a\u6837\u6027\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u3002<\/span><\/section>\n<section style=\"text-indent: 12pt;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">2.<\/span><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u591a\u5b66\u79d1\u6574\u5408\u7684\u7814\u7a76\u65b9\u6cd5\uff1a<\/span><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u7814\u7a76\u7ed3\u5408\u4e86\u964d\u7ef4\u5206\u6790\u3001\u805a\u7c7b\u5206\u6790\u7b49\u5148\u8fdb\u7684\u751f\u7269\u4fe1\u606f\u5b66\u65b9\u6cd5\u4ee5\u53ca\u5206\u5b50\u751f\u7269\u5b66\u548c\u9057\u4f20\u5b66\u7b49\u591a\u5b66\u79d1\u5de5\u5177\u548c\u65b9\u6cd5\uff0c\u8bc6\u522b\u548c\u5206\u7c7b\u4e86\u5fc3\u810f\u4e2d\u4e0d\u540c\u7684\u7ec6\u80de\u7fa4\u4f53\uff0c\u8fdb\u800c\u63ed\u793a\u4e86\u5de8\u566c\u7ec6\u80de\u5411\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u8f6c\u5316\u7684\u751f\u7269\u5b66\u8fc7\u7a0b\uff0c\u5c55\u793a\u4e86\u591a\u5b66\u79d1\u878d\u5408\u7814\u7a76\u5728\u590d\u6742\u751f\u7269\u6570\u636e\u89e3\u6790\u4e2d\u7684\u5e94\u7528\u4ef7\u503c\u3002<\/span><\/section>\n<section style=\"text-indent: 12pt;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">3.<\/span><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u63ed\u793a\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u7684\u65b0\u529f\u80fd\uff1a<\/span><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u672c\u7814\u7a76\u53d1\u73b0\u4e86\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u5728\u5fc3\u810f\u7ea4\u7ef4\u5316\u4e2d\u7684\u65b0\u89d2\u8272\uff0c\u7279\u522b\u662f\u5b83\u4eec\u901a\u8fc7ALKBH5\u4ecb\u5bfc\u7684m6A\u4fee\u9970\u53c2\u4e0e\u4e86\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5316\u8fc7\u7a0b\u3002\u8fd9\u4e00\u53d1\u73b0\u4e3a\u5fc3\u810f\u7ea4\u7ef4\u5316\u7684\u7ec6\u80de\u673a\u5236\u7814\u7a76\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u3002<\/span><\/section>\n<section style=\"text-indent: 12pt;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">4.<\/span><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u9610\u660e\u5fc3\u810f\u7ea4\u7ef4\u5316\u7684\u5206\u5b50\u673a\u5236\uff1a<\/span><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u901a\u8fc7\u7814\u7a76ALKBH5\u5728\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u4e2d\u7684\u4f5c\u7528\uff0c\u63ed\u793a\u4e86\u5fc3\u810f\u7ea4\u7ef4\u5316\u8fc7\u7a0b\u4e2dm6A\u4fee\u9970\u5bf9IL-11 mRNA\u7a33\u5b9a\u6027\u548c\u8868\u8fbe\u7684\u5f71\u54cd\uff0c\u4e3a\u5fc3\u810f\u7ea4\u7ef4\u5316\u7684\u5206\u5b50\u8c03\u63a7\u673a\u5236\u589e\u6dfb\u4e86\u65b0\u7684\u5c42\u6b21\u3002<\/span><span style=\"letter-spacing: 1px;text-indent: -18pt;font-size: var(--articleFontsize);\">    <\/span><\/section>\n<section style=\"text-align: justify;margin-left: 36pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(68, 114, 196);font-weight: bold;letter-spacing: 1px;\">\uff08ps\uff1a\u60f3\u4e86\u89e3\u66f4\u591a\u751f\u4fe1\u5206\u6790\u601d\u8def\uff1f\u8fd8\u4e0d\u8d76\u5feb\u626b\u7801\u8054\u7cfb\u9986\u957f\uff01\u8fd9\u91cc\u6709\u65b0\u9c9c\u51fa\u7089\u7684\u751f\u4fe1\u70ed\u70b9\u65b9\u5411\uff0c\u8fd8\u6709\u7528\u4e4b\u4e0d\u5c3d\u7684\u521b\u65b0\u578b\u601d\u8def\uff01\uff09<\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100006476\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_f6PG40Qrdu5e9B1iaIMItPiajABYWA-56.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxqaqPbQprPd4vw8Ytp0cprbzXiakMDdFriaB6B59ibhlBCrNyQFf6PG40Qrdu5e9B1iaIMItPiajABYWA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 235px;height: 235px;\" data-recalc-dims=\"1\" \/><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009846\" data-ratio=\"0.5349794238683128\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_pLvF8bSQ1Ov6EiarZadWrgQGgJK1yg.png?resize=553%2C296\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6vV1FaHWmckN2OAnNuCWvCxHSRrl5X1o2aErZHShD5IUaItpLvF8bSQ1Ov6EiarZadWrgQGgJK1yg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"729\" height=\"296 .2699890136719\" width=\"553 .739990234375\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u9898\u76ee\uff1aALKBH5\u4ecb\u5bfc\u7684IL-11 \u7684m6A\u4fee\u9970\u9a71\u52a8\u5c0f\u9f20\u5de8\u566c\u7ec6\u80de\u5411\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u8f6c\u5316\u548c\u75c5\u7406\u6027\u5fc3\u810f\u7ea4\u7ef4\u5316<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6742\u5fd7\uff1aNature Communication<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=16.6<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e743\u67085\u65e5<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><br \/><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);letter-spacing: 1px;\">\u7814\u7a76\u80cc\u666f<\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;text-indent: 21pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u8be5\u7814\u7a76\u80cc\u666f\u4e3b\u8981\u96c6\u4e2d\u5728\u63a2\u7d22\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u5728\u5fc3\u810f\u7ea4\u7ef4\u5316\u8fc7\u7a0b\u4e2d\u7684\u89d2\u8272\u53ca\u5176\u8c03\u8282\u673a\u5236\u4e0a\u3002\u5fc3\u529b\u8870\u7aed\uff0c\u7279\u522b\u662f\u4ee5\u75c5\u7406\u6027\u5fc3\u810f\u7ea4\u7ef4\u5316\u548c\u80a5\u5927\u4e3a\u7279\u5f81\u7684\u7c7b\u578b\uff0c\u662f\u5168\u7403\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u7684\u4e00\u4e2a\u91cd\u8981\u539f\u56e0\u3002\u5fc3\u810f\u7ea4\u7ef4\u5316\u662f\u4e00\u4e2a\u590d\u6742\u7684\u751f\u7269\u8fc7\u7a0b\uff0c\u5176\u7279\u5f81\u662f\u6210\u7ea4\u7ef4\u7ec6\u80de\u6d3b\u5316\u5e76\u5206\u5316\u4e3a\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u5bfc\u81f4\u8fc7\u91cf\u7684\u7ec6\u80de\u5916\u57fa\u8d28\u6c89\u79ef\u3002<\/span><span style=\"letter-spacing: 1px;text-indent: 21pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u7814\u7a76\u663e\u793a\uff0c\u4fc3\u708e\u72b6\u6001\u662f\u5fc3\u810f\u7ea4\u7ef4\u5316\u75c5\u7406\u751f\u7406\u5b66\u7684\u4e3b\u8981\u51b3\u5b9a\u56e0\u7d20\u4e4b\u4e00\uff0c\u800c\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u5219\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002<\/span><span style=\"letter-spacing: 1px;text-indent: 21pt;font-size: var(--articleFontsize);\">    <\/span><\/section>\n<section style=\"text-indent: 21pt;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);\">\u6570\u636e\u6765\u6e90<\/span><\/span><\/section>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"100%\" style=\"border-width: initial;border-style: none;border-color: initial;border-collapse: collapse;width: 100%;\">\n<tbody>\n<tr style=\"height:23.6pt;\">\n<td width=\"202\" valign=\"top\" style=\"width:35.56%;background:#5B9BD5;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;height:23.6pt;\">\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);letter-spacing: 1px;\">\u6570\u636e\u7c7b\u578b<\/span><\/section>\n<\/td>\n<td width=\"366\" valign=\"top\" style=\"width:64.44%;background:#5B9BD5;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:23.6pt;\">\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);letter-spacing: 1px;\">\u8be6\u7ec6\u4fe1\u606f<\/span><\/section>\n<\/td>\n<\/tr>\n<tr style=\"height:49.05pt;\">\n<td width=\"202\" nowrap=\"nowrap\" valign=\"top\" style=\"width:35.56%;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:49.05pt;\">\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-size: 15px;letter-spacing: 1px;\">scRNA-seq<\/span><\/section>\n<\/td>\n<td width=\"366\" nowrap=\"nowrap\" valign=\"top\" style=\"width:64.44%;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;height:49.05pt;\">\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;color: rgb(51, 51, 51);letter-spacing: 1px;font-size: 15px;\">\u6765\u81ea\u8840\u7ba1\u7d27\u5f20\u7d20II (Ang II) \u5904\u7406\u7684C57BL\/6\u5c0f\u9f20\u5fc3\u810f\u7684\u975e\u5fc3\u808c\u7ec6\u80de<\/span><\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);\"><br \/>\u7814\u7a76\u601d\u8def<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-size: 12pt;letter-spacing: 1px;text-indent: 21pt;\">\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u91c7\u7528\u4e86\u4e00\u7cfb\u5217\u7efc\u5408\u65b9\u6cd5\u6765\u63a2\u7d22\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u5728\u5fc3\u810f\u7ea4\u7ef4\u5316\u4e2d\u7684\u89d2\u8272\u53ca\u5176\u8c03\u63a7\u673a\u5236\u3002<\/span><span style=\"font-family: \u5b8b\u4f53;font-size: 12pt;letter-spacing: 1px;text-indent: 21pt;\">\u9996\u5148\uff0c\u901a\u8fc7\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6280\u672f\uff0c\u4ece\u8840\u7ba1\u7d27\u5f20\u7d20II\u5904\u7406\u7684\u5c0f\u9f20\u5fc3\u810f\u4e2d\u5206\u79bb\u5355\u4e2a\u7ec6\u80de\uff0c\u5206\u6790\u5176\u57fa\u56e0\u8868\u8fbe\uff0c\u4ee5\u8bc6\u522b\u4e0d\u540c\u7ec6\u80de\u7fa4\u4f53\u5e76\u63a2\u7d22\u5de8\u566c\u7ec6\u80de\u7684\u529f\u80fd\u3002<\/span><span style=\"font-family: \u5b8b\u4f53;font-size: 12pt;letter-spacing: 1px;text-indent: 21pt;\">\u5229\u7528\u7279\u5b9a\u7684\u57fa\u56e0\u6807\u8bb0\u7cfb\u7edf\u5bf9\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u7684\u6765\u6e90\u8fdb\u884c\u8c31\u7cfb\u8ffd\u8e2a\uff0c\u7ed3\u5408\u5f02\u79cd\u5171\u751f\u5b9e\u9a8c\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u5411\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8f6c\u5316\u3002<\/span><span style=\"font-family: \u5b8b\u4f53;font-size: 12pt;letter-spacing: 1px;text-indent: 21pt;\">\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u6572\u9664\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u4e2d\u7684ALKBH5\u57fa\u56e0\uff0c\u7814\u7a76\u4e86\u5176\u5bf9\u5fc3\u810f\u7ea4\u7ef4\u5316\u548c\u529f\u80fd\u7684\u5f71\u54cd\uff0c\u63ed\u793a\u4e86ALKBH5\u5728\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u8f6c\u5316\u548c\u5fc3\u810f\u7ea4\u7ef4\u5316\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u3002<\/span><span style=\"font-family: \u5b8b\u4f53;font-size: 12pt;letter-spacing: 1px;text-indent: 21pt;\">RNA\u514d\u75ab\u6c89\u6dc0\u6d4b\u5e8f\u8fdb\u4e00\u6b65\u9274\u5b9a\u4e86ALKBH5\u7684\u76f4\u63a5\u9776\u6807\uff0c\u767d\u4ecb\u7d20-11 (IL-11) mRNA\uff0c\u5e76\u901a\u8fc7m6A\u70b9\u5370\u8ff9\u6280\u672f\u548c\u86cb\u767d\u8d28\u6c34\u5e73\u7684\u6d4b\u5b9a\uff0c\u63ed\u793a\u4e86ALKBH5\u901a\u8fc7m6A\u4fee\u9970\u8c03\u63a7IL-11\u8868\u8fbe\u7684\u673a\u5236\u3002<\/span><span style=\"font-family: \u5b8b\u4f53;font-size: 12pt;letter-spacing: 1px;text-indent: 21pt;\">\u6700\u540e\uff0c\u901a\u8fc7\u5fc3\u529f\u80fd\u548c\u7ea4\u7ef4\u5316\u8bc4\u4f30\uff0c\u5305\u62ec\u8d85\u58f0\u5fc3\u52a8\u56fe\u548cMasson\u4e09\u8272\u67d3\u8272\uff0c\u7cfb\u7edf\u5730\u5206\u6790\u4e86ALKBH5\u6572\u9664\u5bf9\u5fc3\u810f\u7ea4\u7ef4\u5316\u548c\u529f\u80fd\u969c\u788d\u7684\u5f71\u54cd\u3002<\/span><\/section>\n<section style=\"text-align: center;text-indent: 21pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);\">\u4e3b\u8981\u7ed3\u679c<\/span><\/span><\/section>\n<section style=\"font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><span style=\"background-color: rgb(255, 251, 0);font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">1.<\/span><span style=\"background-color: rgb(255, 251, 0);font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u548c\u964d\u7ef4\u5206\u6790<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u9996\u5148\u4f7f\u7528\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6280\u672f\u5206\u6790\u8840\u7ba1\u7d27\u5f20\u7d20II (Ang II) \u5904\u7406\u7684C57BL\/6\u5c0f\u9f20\u4e2d\u5206\u79bb\u5fc3\u810f\u7684\u975e\u5fc3\u808c\u7ec6\u80de\uff0c\u5e76\u8fdb\u884c\u4e86\u57fa\u56e0\u8868\u8fbe\u5206\u6790\u3002\u63a5\u7740\uff0c\u901a\u8fc7UMAP\uff08\u5747\u5300\u6d41\u5f62\u8fd1\u4f3c\u548c\u6295\u5f71\uff09\u964d\u7ef4\u5206\u6790\uff0c\u8bc6\u522b\u51fa\u4e86\u5305\u62ec\u5de8\u566c\u7ec6\u80de\u548c\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u5728\u5185\u7684\u4e0d\u540c\u7ec6\u80de\u7fa4\u4f53\u3002\u76f4\u89c2\u5730\u663e\u793a\u4e86\u4e00\u5c0f\u90e8\u5206\u5faa\u73af\u5355\u6838\u7ec6\u80de\u6e90\u7684\u5de8\u566c\u7ec6\u80de\u8f6c\u5316\u4e3a\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8ff9\u8c61\uff0c\u8868\u660e\u5b83\u4eec\u53ef\u80fd\u53d1\u751f\u4e86\u8f6c\u5316\u3002\u8fd9\u4e5f\u95f4\u63a5\u5c55\u793a\u4e86\u9ad8\u8840\u538b\u589e\u52a0\u5de8\u566c\u7ec6\u80de-\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u8f6c\u5316\uff08MMT\uff09\u7684\u8bc1\u636e\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009848\" data-ratio=\"1.106446776611694\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_fTswTibtbfrdD8ozbCPkRE21AOb1wg.jpg?resize=492%2C544\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx6vV1FaHWmckN2OAnNuCWvCbu8YKkqC9F2ibsXibhVWWomMqCPfTswTibtbfrdD8ozbCPkRE21AOb1wg\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"667\" height=\"544 .3699951171875\" width=\"492 .0099792480469\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u56fe\u4e00<\/span><\/section>\n<section style=\"font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><span style=\"background-color: rgb(255, 251, 0);font-size: 12pt;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">2.<\/span><span style=\"background-color: rgb(255, 251, 0);font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u8c31\u7cfb\u8ffd\u8e2a\u548c\u5f02\u79cd\u5171\u751f\u5b9e\u9a8c<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u5229\u7528Cre\/LoxP\u7cfb\u7edf\u5728\u7279\u5b9a\u7684\u8f6c\u57fa\u56e0\u5c0f\u9f20\u6a21\u578b\u4e2d\u6807\u8bb0\u5de8\u566c\u7ec6\u80de\uff0c\u5e76\u901a\u8fc7\u5f02\u79cd\u5171\u751f\u5b9e\u9a8c\u6765\u8ddf\u8e2a\u5de8\u566c\u7ec6\u80de\u7684\u6765\u6e90\u548c\u547d\u8fd0\u3002\u901a\u8fc7\u5206\u6790ALKBH5\u5728\u5de8\u566c\u7ec6\u80de\u4e2d\u7684\u8868\u8fbe\u548c\u529f\u80fd\uff0c\u63ed\u793a\u4e86ALKBH5\u4e0a\u8c03\u53c2\u4e0e\u9ad8\u8840\u538b\u8bf1\u5bfc\u7684\u5fc3\u810fMMT\u3002\u7279\u522b\u662f\uff0cALKBH5\u5728\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u6837\u7684\u5de8\u566c\u7ec6\u80de\u4e2d\u8868\u8fbe\u589e\u52a0\uff0c\u5e76\u4e14\u5de8\u566c\u7ec6\u80de\u4e2dm6A\u7532\u57fa\u5316\u6c34\u5e73\u5728Ang II\u5904\u7406\u540e\u663e\u8457\u964d\u4f4e\uff0c\u63d0\u793aALKBH5\u901a\u8fc7\u8c03\u8282m6A\u4fee\u9970\u5f71\u54cdMMT\u3002\u56fe\u4e8c\u5c55\u793a\u4e86\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u4ece\u5faa\u73af\u5355\u6838\u7ec6\u80de\u8f6c\u5316\u4e3a\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8fc7\u7a0b\uff0c\u76f4\u89c2\u5730\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u548c\u514d\u75ab\u8367\u5149\u67d3\u8272\u9a8c\u8bc1\u4e86\u8fd9\u4e00\u8f6c\u5316\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: center;margin-left: 18pt;text-indent: 0pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009847\" data-ratio=\"0.83\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_33V6xUqbBviaF3icbeJUDUB0U0IEwA.jpg?resize=510%2C424\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx6vV1FaHWmckN2OAnNuCWvCFQ4iaT9ze6SGFUbG5MtiayRlGrSJ33V6xUqbBviaF3icbeJUDUB0U0IEwA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"800\" height=\"424 .0099792480469\" width=\"510 .8499755859375\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u56fe\u4e8c<\/span><\/section>\n<section style=\"font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><span style=\"background-color: rgb(255, 251, 0);font-size: 12pt;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">3.<\/span><span style=\"background-color: rgb(255, 251, 0);font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">ALKBH5\u529f\u80fd\u5206\u6790<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5728\u8fd9\u4e00\u73af\u8282\uff0c\u4f5c\u8005\u901a\u8fc7\u57fa\u56e0\u6572\u9664\u6280\u672f\u7279\u5f02\u6027\u79fb\u9664\u5de8\u566c\u7ec6\u80de\u4e2d\u7684ALKBH5\uff0c\u5e76\u91c7\u7528\u5fc3\u810f\u529f\u80fd\u6d4b\u91cf\u6280\u672f\uff08\u5982\u8d85\u58f0\u5fc3\u52a8\u56fe\uff09\u8bc4\u4f30\u5f71\u54cd\u3002\u8fd9\u4e24\u5f20\u56fe\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86ALKBH5\u5728\u5de8\u566c\u7ec6\u80de-\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u8f6c\u5316\u548c\u5fc3\u810f\u7ea4\u7ef4\u5316\u4e2d\u7684\u4f5c\u7528\u3002\u901a\u8fc7\u6784\u5efaALKBH5\u57fa\u56e0\u6572\u9664\u7684\u5c0f\u9f20\u6a21\u578b\uff0c\u53d1\u73b0ALKBH5\u7684\u7f3a\u5931\u51cf\u5c11\u4e86Ang II\u5f15\u8d77\u7684\u5fc3\u810f\u7ea4\u7ef4\u5316\u548c\u529f\u80fd\u969c\u788d\uff0c\u8bc1\u660e\u4e86ALKBH5\u5728\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u8f6c\u5316\u548c\u5fc3\u810f\u7ea4\u7ef4\u5316\u53d1\u5c55\u4e2d\u627f\u62c5\u5173\u952e\u89d2\u8272\u3002<\/span>    <span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-weight: bold;\">         <o:p> <\/o:p><\/span><span style=\"font-family: "Times New Roman";font-size: 12pt;\">       <\/span><\/span><o:p style=\"font-family: "Times New Roman";font-size: 12pt;letter-spacing: 0.034em;\"><span style=\"letter-spacing: 1px;\"> <\/span><\/o:p><span style=\"font-family: \u5b8b\u4f53;font-size: 12pt;font-weight: bold;text-indent: 0pt;letter-spacing: 1px;\">         <\/span><o:p style=\"font-family: \u5b8b\u4f53;font-size: 12pt;font-weight: bold;text-indent: 0pt;letter-spacing: 0.034em;\"><span style=\"letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009849\" data-ratio=\"0.89\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_Z3cAD1cvJvVABLCWjS0CxicZutoH8w.jpg?resize=488%2C434\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx6vV1FaHWmckN2OAnNuCWvCMrgyBqxg4hmfXI2G86DslqQVsZ3cAD1cvJvVABLCWjS0CxicZutoH8w\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"800\" height=\"434 .30999755859375\" width=\"488 .0099792480469\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe\u4e09<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009850\" data-ratio=\"0.8675\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_iaFvUZPc2ZJ1sIIUYfqW5jvic6AGQQ.jpg?resize=501%2C434\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx6vV1FaHWmckN2OAnNuCWvCZA3VoWGMu4FrnNQfyzaKFaCPfDiaFvUZPc2ZJ1sIIUYfqW5jvic6AGQQ\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"800\" height=\"434 .60003662109375\" width=\"501 .010009765625\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u56fe\u56db<\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><span style=\"background-color: rgb(255, 251, 0);font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">4.<\/span><span style=\"background-color: rgb(255, 251, 0);font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">RNA\u514d\u75ab\u6c89\u6dc0\u6d4b\u5e8f\uff08RIP-seq\uff09\u548cm6A\u70b9\u5370\u8ff9\u6280\u672f<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;font-weight: normal;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe\u4e94\u5c55\u793a\u4e86\u4f5c\u8005\u5229\u7528RIP-seq\u8bc6\u522bALKBH5\u76f4\u63a5\u4f5c\u7528\u7684RNA\u9776\u6807\uff0cm6A\u70b9\u5370\u8ff9\u6280\u672f\u8bc4\u4f30\u5de8\u566c\u7ec6\u80de\u4e2dm6A\u4fee\u9970\u7684\u53d8\u5316\u3002\u7ed3\u679c\u63ed\u793a\u4e86ALKBH5\u76f4\u63a5\u8c03\u63a7m6A\u5bf9IL-11 mRNA\u7684\u4fee\u9970\uff0c\u901a\u8fc7RNA\u514d\u75ab\u6c89\u6dc0\u6d4b\u5e8f(RIP-seq)\u8bc6\u522b\u4e86ALKBH5\u7684\u76f4\u63a5\u9776\u6807\u4e4b\u4e00\u4e3aIL-11 mRNA\u3002ALKBH5\u4ecb\u5bfc\u7684m6A\u53bb\u7532\u57fa\u5316\u5f71\u54cd\u4e86IL-11 mRNA\u7684\u7a33\u5b9a\u6027\u548c\u8868\u8fbe\uff0c\u76f4\u63a5\u94fe\u63a5\u4e86ALKBH5\u7684\u751f\u7269\u5b66\u529f\u80fd\u4e0e\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u7684\u8f6c\u5316\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009851\" data-ratio=\"0.66875\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_gj1DkP1q4cKCWrxBjH9sYKVBjKiaPA.jpg?resize=553%2C370\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx6vV1FaHWmckN2OAnNuCWvCUuH8wJHBESK45azxDA6HL1Iasgj1DkP1q4cKCWrxBjH9sYKVBjKiaPA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"800\" height=\"370 .3399963378906\" width=\"553 .739990234375\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u56fe\u4e94<\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><span style=\"background-color: rgb(255, 251, 0);font-size: 12pt;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">5.<\/span><span style=\"background-color: rgb(255, 251, 0);font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">IL-11\u8fc7\u8868\u8fbe\u548c\u9aa8\u9ad3\u79fb\u690d\u5b9e\u9a8c<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u63a5\u7740\uff0c\u901a\u8fc7\u9aa8\u9ad3\u79fb\u690d\u5b9e\u9a8c\u5728\u5faa\u73af\u5355\u6838\u7ec6\u80de\u4e2d\u7279\u5f02\u6027\u8fc7\u8868\u8fbeIL11\uff0c\u4f5c\u8005\u8bc4\u4f30\u4e86\u5176\u5bf9\u5fc3\u810f\u7ea4\u7ef4\u5316\u7684\u5f71\u54cd\u3002\u901a\u8fc7IL-11\u8fc7\u8868\u8fbe\u548c\u9aa8\u9ad3\u79fb\u690d\u5b9e\u9a8c\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86IL-11\u5728ALKBH5\u4ecb\u5bfc\u7684\u5fc3\u810f\u7ea4\u7ef4\u5316\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\u3002\u8fd9\u4e9b\u5b9e\u9a8c\u663e\u793a\uff0cIL-11\u8fc7\u8868\u8fbe\u53ef\u4ee5\u9006\u8f6cALKBH5\u7f3a\u5931\u5f15\u8d77\u7684\u5fc3\u810f\u529f\u80fd\u6539\u5584\u548c\u7ea4\u7ef4\u5316\u51cf\u5c11\uff0c\u5f3a\u8c03\u4e86IL-11\u5728\u5de8\u566c\u7ec6\u80de\u8f6c\u5316\u548c\u5fc3\u810f\u7ea4\u7ef4\u5316\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u5e76\u63d0\u4f9b\u4e86\u6cbb\u7597\u5fc3\u810f\u7ea4\u7ef4\u5316\u7684\u6f5c\u5728\u9776\u6807\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009853\" data-ratio=\"0.80125\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_UmicZ3FtibL04rqgQPLSZsvM3FbdCA.jpg?resize=553%2C443\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx6vV1FaHWmckN2OAnNuCWvCIGLh9BfMicUg4T7NArYTzRRhnWbUmicZ3FtibL04rqgQPLSZsvM3FbdCA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"800\" height=\"443 .6700439453125\" width=\"553 .739990234375\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u56fe\u516d<\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"background-color: rgb(255, 251, 0);letter-spacing: 1px;\"><span style=\"background-color: rgb(255, 251, 0);font-size: 12pt;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">6.<\/span><span style=\"background-color: rgb(255, 251, 0);font-size: 12pt;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u7eb3\u7c73\u9897\u7c92\u4ecb\u5bfc\u7684siRNA\u9012\u9001<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6700\u540e\uff0c\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u4e86\u7279\u5b9a\u7684\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\uff08LNPs\uff09\u8f7d\u4f53\uff0c\u9776\u5411\u9012\u9001ALKBH5 siRNA\u5230\u5faa\u73af\u5355\u6838\u7ec6\u80de\/\u5de8\u566c\u7ec6\u80de\uff0c\u4ee5\u51cf\u8f7b\u5fc3\u810f\u7ea4\u7ef4\u5316\u3002\u6700\u7ec8\uff0c\u6210\u529f\u5730\u5c06ALKBH5 siRNA\u9012\u9001\u5230\u76ee\u6807\u7ec6\u80de\uff0c\u51cf\u5c11\u4e86Ang II\u5f15\u8d77\u7684\u5fc3\u810f\u7ea4\u7ef4\u5316\u548c\u529f\u80fd\u969c\u788d\uff0c\u8fd9\u4e9b\u76f4\u89c2\u7ed3\u679c\u652f\u6301\u4e86\u901a\u8fc7\u9776\u5411ALKBH5\/IL-11\u9014\u5f84\u6cbb\u7597\u5fc3\u810f\u7ea4\u7ef4\u5316\u7684\u7b56\u7565\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100009852\" data-ratio=\"0.8986232790988736\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_vFNia21oK2m0kIAw73FGUicRamlxHA.jpg?resize=553%2C497\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/vdJbOia6pHx6vV1FaHWmckN2OAnNuCWvCqKcpYUx00NUw0W6uDMZkDMxeWUvFNia21oK2m0kIAw73FGUicRamlxHA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"799\" height=\"497 .6099853515625\" width=\"553 .739990234375\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u56fe\u4e03<\/span><\/section>\n<section style=\"text-align: center;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;text-indent: 21pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u672c\u7814\u7a76\u901a\u8fc7\u7efc\u5408\u8fd0\u7528\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u3001\u8c31\u7cfb\u8ffd\u8e2a\u3001\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u548c\u529f\u80fd\u6027\u5206\u6790\u7b49\u591a\u79cd\u751f\u7269\u4fe1\u606f\u5b66\u548c\u5206\u5b50\u751f\u7269\u5b66\u65b9\u6cd5\uff0c\u63a2\u7d22\u4e86\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u5728\u5fc3\u810f\u7ea4\u7ef4\u5316\u4e2d\u7684\u4f5c\u7528\u53ca\u5176\u8c03\u63a7\u673a\u5236\uff0c\u7279\u522b\u662f\u63ed\u793a\u4e86ALKBH5\u4ecb\u5bfc\u7684m6A\u4fee\u9970\u5728\u8c03\u63a7\u5de8\u566c\u7ec6\u80de\u5411\u808c\u6210\u7ea4\u7ef4\u7ec6\u80de\u8f6c\u5316\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff0c\u4ee5\u53ca\u8fdb\u4e00\u6b65\u5f71\u54cd\u5fc3\u810f\u7ea4\u7ef4\u5316\u7684\u8fc7\u7a0b\u3002\u8be5\u7814\u7a76\u4e0d\u4ec5\u63ed\u793a\u4e86\u5fc3\u810f\u5de8\u566c\u7ec6\u80de\u5728\u5fc3\u810f\u7ea4\u7ef4\u5316\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u4e5f\u4e3a\u5fc3\u810f\u7ea4\u7ef4\u5316\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u6f5c\u5728\u9776\u70b9\u3002<\/span><span style=\"letter-spacing: 1px;text-indent: 21pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u9986\u957f\u8ba4\u4e3a\uff0c\u8fd9\u9879\u7814\u7a76\u5927\u5bb6\u63d0\u4f9b\u4e86\u4e00\u7cfb\u5217\u7684\u7814\u7a76\u65b9\u6cd5\u3001\u7b56\u7565\u548c\u601d\u8def\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u90a3\u4e9b\u5bf9\u5355\u7ec6\u80de\u6280\u672f\u3001\u57fa\u56e0\u7f16\u8f91\u548c\u75be\u75c5\u673a\u5236\u7814\u7a76\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u4eec\u6765\u8bf4\uff0c\u5177\u6709\u5f88\u9ad8\u7684\u5b66\u4e60\u4ef7\u503c\u54e6\uff01\u4e0d\u6127\u80fd\u53d1\u523016+\u5462\uff01<\/span><span style=\"letter-spacing: 1px;text-indent: 21pt;font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(255, 0, 0);font-weight: bold;\">\u770b\u5230\u8fd9\u513f\uff0c\u5c0f\u4f19\u4f34\u4eec\u5fc3\u91cc\u662f\u5426\u5df2\u7ecf\u8feb\u4e0d\u53ca\u5f85\u60f3\u8981\u5b66\u4e60\u4e86\u5462\uff1f\u770b\u5230\u522b\u7684\u56e2\u961f\u4f73\u4f5c\u4e0d\u65ad\uff0c\u4f60\u662f\u5426\u4e5f\u5df2\u7ecf\u60f3\u8981\u5927\u5c55\u8eab\u624b\u4e86\uff1f\u5feb\u5feb\u626b\u7801\u8054\u7cfb\u9986\u957f\uff0c\u9986\u957f\u5e26\u4f60\u8d70\u5411\u751f\u4fe1\u7814\u7a76\u98de\u5347\u8def\uff01<\/span><\/section>\n<section style=\"text-indent: 21pt;text-align: justify;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 12pt;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(255, 0, 0);font-weight: bold;\"><\/span><\/span><\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100017513\" data-ratio=\"0.7621359223300971\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_XiafCUEp1NqZoBA3F9mvRcJR4PQ1Tw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAyZkFgOs95yxYHqY7n8a8k4wWKhXgwQvZVTwDhgYYDDu7asGXiafCUEp1NqZoBA3F9mvRcJR4PQ1Tw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"618\" style=\"\" data-recalc-dims=\"1\" \/><\/p>\n<section style=\"font-size: 16px;margin-bottom: 0px;\">\n<section style=\"margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"text-align: justify;justify-content: flex-start;display: flex;flex-flow: row;will-change: transform;\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;color: rgb(228, 238, 248);font-size: 26px;\">\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);letter-spacing: 1px;\"><strong><span style=\"color: rgb(0, 122, 170);text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017465\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_B2jkicacLzPjw4xMSqVvoucZjonVDA-13.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><span style=\"letter-spacing: 1px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/span><\/p>\n<p style=\"margin-bottom: 2px;\"><span style=\"letter-spacing: 1px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/span><\/p>\n<p><span style=\"letter-spacing: 1px;\"><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span style=\"letter-spacing: 1px;\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017467\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_7TvAyUibd1TPhJmZfialJtv6tu2SEg-30.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/span><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100017466\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/14_9N02aBaau07RufXeXRLmvAHsrFZxtw-28.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;text-wrap: wrap;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><span style=\"letter-spacing: 1px;\"><strong>\u5f80\u671f\u56de\u987e<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"letter-spacing: 1px;\"><strong>01<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);letter-spacing: 1px;\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"letter-spacing: 1px;\"><strong>02<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);letter-spacing: 1px;\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"letter-spacing: 1px;\"><strong>03<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);letter-spacing: 1px;\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"letter-spacing: 1px;\"><strong>04<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);letter-spacing: 1px;\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;margin-bottom: 0px;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section>\n<section powered-by=\"xiumi.us\">\n<section>\n<section powered-by=\"xiumi.us\">\n<section><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-bottom: 0px;line-height: 1.6em;\">\n<section style=\"display: none;margin-bottom: 24px;text-align: justify;margin-top: 8px;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/section>\n<\/section>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature Communication\uff01\u56fd\u81ea\u7136TOP\u7ea7\u70ed\u70b9\uff01\u5355\u7ec6\u80de+\u5de8\u566c\u7ec6\u80de+\u8868\u89c2\u9057\u4f20\u9a71\u52a8\uff0c\u590d\u65e6\u5927\u5b66\u56e2\u961f\uff0c\u8fd9 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/56493"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=56493"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/56493\/revisions"}],"predecessor-version":[{"id":56508,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/56493\/revisions\/56508"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=56493"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=56493"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=56493"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}