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style=\"letter-spacing: 0.5px;\"><strong><span style=\"font-size: 15px;\">\u751f\u4fe1\u4ebaR\u8bed\u8a00\u5b66\u4e60\u5fc5\u5907<\/span><\/strong><\/span><\/p>\n<p style=\"text-indent: 0em;line-height: 1.75em;\"><span style=\"letter-spacing: 0.5px;\"><strong><span style=\"font-size: 15px;\">\u7acb\u523b\u62e5\u6709\u4e00\u4e2aRstudio\u8d26\u53f7<\/span><\/strong><\/span><\/p>\n<p style=\"text-indent: 0em;line-height: 1.75em;\"><span style=\"letter-spacing: 0.5px;\"><strong><span style=\"font-size: 15px;\">\u5f00\u542f\u5347\u7ea7\u6a21\u5f0f\u5427<\/span><\/strong><\/span><\/p>\n<p style=\"text-indent: 0em;line-height: 1.75em;\"><span style=\"color: rgb(255, 129, 36);font-size: 12px;letter-spacing: 0.5px;\">\uff0856\u7ebf\u7a0b\uff0c256G\u5185\u5b58\uff0c\u4e2a\u4eba\u5b58\u50a81T\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 29.9652%;align-self: flex-start;flex: 0 0 auto;height: 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\u6bd4\u8f83\u4e0d\u540c\u6cbb\u7597\u7ec4\u6216\u6cbb\u7597\u65b9\u6848\u7684\u751f\u5b58\u5dee\u5f02\uff1a\u4f8b\u5982\uff0c\u5bf9\u4e8e\u67d0\u79cd\u764c\u75c7\uff0c\u53ef\u4ee5\u5c06\u60a3\u8005\u5206\u4e3a\u63a5\u53d7\u4e0d\u540c\u6cbb\u7597\u65b9\u6848\u7684\u7ec4\uff0c\u5e76\u6bd4\u8f83\u5404\u7ec4\u7684\u751f\u5b58\u60c5\u51b5\u3002 <\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u8bc4\u4f30\u9884\u540e\u56e0\u7d20\u5bf9\u751f\u5b58\u7684\u5f71\u54cd\uff1a\u4f8b\u5982\uff0c\u7814\u7a76\u7279\u5b9a\u57fa\u56e0\u53d8\u5f02\u4e0e\u60a3\u8005\u751f\u5b58\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u6216\u8005\u8bc4\u4f30\u5176\u4ed6\u4e34\u5e8a\u7279\u5f81\uff08\u5982\u5e74\u9f84\u3001\u6027\u522b\u3001\u80bf\u7624\u5206\u671f\u7b49\uff09\u5bf9\u751f\u5b58\u7684\u5f71\u54cd\u3002<\/span><o:p><\/o:p><\/p>\n<p><span style=\"font-size: 14px;\"><br \/><\/span><\/p>\n<p><span style=\"text-decoration: underline;\"><strong><span style=\"text-decoration: underline;font-size: 14px;color: rgb(0, 122, 170);\">\u7ed8\u5236KM\u66f2\u7ebf\u7684\u6b65\u9aa4\u5982\u4e0b\uff1a<\/span><\/strong><\/span><span style=\"font-size: 14px;\"><\/span><\/p>\n<p><span style=\"font-size: 14px;\"> \u6536\u96c6\u751f\u5b58\u6570\u636e\uff1a\u5305\u62ec\u6bcf\u4e2a\u4e2a\u4f53\u7684\u751f\u5b58\u65f6\u95f4\u548c\u4e8b\u4ef6\u72b6\u6001\uff08\u5982\u751f\u5b58\u6216\u6b7b\u4ea1\uff09\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u6839\u636e\u7814\u7a76\u76ee\u7684\u548c\u53d8\u91cf\u7279\u5f81\uff0c\u5c06\u4e2a\u4f53\u5206\u4e3a\u4e0d\u540c\u7684\u7ec4\u522b\uff08\u4f8b\u5982\u6cbb\u7597\u7ec4\u548c\u5bf9\u7167\u7ec4\uff09\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u4f7f\u7528Kaplan-Meier\u65b9\u6cd5\u8ba1\u7b97\u6bcf\u4e2a\u7ec4\u522b\u4e2d\u5728\u7ed9\u5b9a\u65f6\u95f4\u70b9\u751f\u5b58\u4e0b\u6765\u7684\u60a3\u8005\u6bd4\u4f8b\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u7ed8\u5236KM\u66f2\u7ebf\uff1a\u5c06\u4e0d\u540c\u7ec4\u522b\u5728\u7ed9\u5b9a\u65f6\u95f4\u70b9\u7684\u751f\u5b58\u6bd4\u4f8b\u7ed8\u5236\u5728\u540c\u4e00\u5f20\u56fe\u4e0a\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.578px;\">\u8fdb\u884c\u7edf\u8ba1\u68c0\u9a8c\uff1a<\/span><span style=\"font-size: 14px;letter-spacing: 0.578px;\">\u4f7f\u7528<\/span><span style=\"font-size: 14px;letter-spacing: 0.578px;\">log-rank<\/span><span style=\"font-size: 14px;letter-spacing: 0.578px;\">\u68c0\u9a8c\u6216\u5176\u4ed6\u5408\u9002\u7684\u65b9\u6cd5\u6bd4\u8f83\u4e0d\u540c\u7ec4\u522b\u4e4b\u95f4\u7684\u751f\u5b58\u5dee\u5f02\u3002<\/span><\/p>\n<p><br \/><\/p>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;letter-spacing: 0.578px;text-wrap: wrap;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"css\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">limma<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">survival<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">survminer<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">data<\/span><span class=\"code-snippet__selector-class\">.table<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">tidyverse<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">ggsignif<\/span>) <\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">RColorBrewer<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;outline: 0px;font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<p style=\"text-align: center;\"><br \/><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.578px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"cs\"><code><span class=\"code-snippet_outer\">#\u9996\u5148\uff0c\u52a0\u8f7d\u4e86\u4e00\u7cfb\u5217\u6240\u9700\u7684R\u5305<\/span><\/code><code><span class=\"code-snippet_outer\">files=dir(\".\/DFI\/\")<\/span><\/code><code><span class=\"code-snippet_outer\">\u901a\u8fc7dir(\".\/DFI\/\")\u83b7\u53d6\".\/DFI\/\"\u76ee\u5f55\u4e0b\u7684\u6587\u4ef6\u5217\u8868\uff0c\u8fd9\u4e9b\u6587\u4ef6\u5305\u542b\u4e86\u6bcf\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u751f\u5b58\u6570\u636e\u3002<\/span><\/code><code><span class=\"code-snippet_outer\">pFilter=1 #pvalue ALL DATA,NO filter <\/span><\/code><code><span class=\"code-snippet_outer\">#if(pValue<pFilter){<\/span><\/code><code><span class=\"code-snippet_outer\"> # if(pValue<0.001){<\/span><\/code><code><span class=\"code-snippet_outer\"> # pValue=\"p<0.001\"<\/span><\/code><code><span class=\"code-snippet_outer\"> # }else{<\/span><\/code><code><span class=\"code-snippet_outer\"> # pValue=paste0(\"p=\",sprintf(\"%.03f\",pValue))<\/span><\/code><code><span class=\"code-snippet_outer\"> #}<\/span><\/code><code><span class=\"code-snippet_outer\">#for tumour types<\/span><\/code><code><span class=\"code-snippet_outer\">#\u901a\u8fc7\u4e00\u4e2a\u5faa\u73af\u904d\u5386\u6bcf\u4e2a\u6587\u4ef6\u8fdb\u884c\u5904\u7406\u3002\u5728\u5faa\u73af\u4e2d\uff0c\u9996\u5148\u8bfb\u53d6\u6587\u4ef6\u5185\u5bb9\u5e76\u8f6c\u6362\u4e3a<\/span><\/code><code><span class=\"code-snippet_outer\">#\u6570\u636e\u6846\u3002\u7136\u540e\u5bf9\u6570\u636e\u6846\u8fdb\u884c\u5904\u7406\uff0c\u8c03\u6574\u5217\u540d\u548c\u6570\u636e\u683c\u5f0f\u3002\u5c06\u5b58\u6d3b\u65f6\u95f4\uff08futime\uff09#\u4ece\u5929\u8f6c\u6362\u4e3a\u5e74\uff0c\u5c06tpm\u8f6c\u6362\u4e3a\u6570\u503c\u578b\u6570\u636e\u3002<\/span><\/code><code><span class=\"code-snippet_outer\">for ( i in 1:length(files) ){<\/span><\/code><code><span class=\"code-snippet_outer\"> dirname=files[i]<\/span><\/code><code><span class=\"code-snippet_outer\"> rt=fread(paste0(\".\/DFI\/\",dirname),header=T,check.names=F)<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">rt=as.data.frame.matrix(rt)<\/span><\/code><\/pre>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.19653179190751446\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_Cw6UJ6XhAHHd5s5sEiaGqAXoZR9sDA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxxXiaZjQfp5iclDXa05tNZJfiaS3DvkDHVibWGtt8Ynz2vocJXRCw6UJ6XhAHHd5s5sEiaGqAXoZR9sDA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"692\" style=\"\" data-recalc-dims=\"1\"><\/p>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;letter-spacing: 0.578px;text-wrap: wrap;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"properties\"><code><span class=\"code-snippet_outer\"> #rownames(rt)=rt[,1]<\/span><\/code><code><span class=\"code-snippet_outer\"> rt=rt[,-1]<\/span><\/code><code><span class=\"code-snippet_outer\"> rt=na.omit(rt)<\/span><\/code><code><span class=\"code-snippet_outer\"> colnames(rt)[1:2]=c(\"fustat\",\"futime\")<\/span><\/code><code><span class=\"code-snippet_outer\"> b=rt[,2]<\/span><\/code><code><span class=\"code-snippet_outer\"> rt=cbind(b,rt)<\/span><\/code><code><span class=\"code-snippet_outer\"> rt=rt[,-3]<\/span><\/code><code><span class=\"code-snippet_outer\">colnames(rt)[1]=\"futime\"<\/span><\/code><\/pre>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.26704545454545453\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_mMeTSLd1LWgBWyVTyQPOgElQy0DD8g.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxxXiaZjQfp5iclDXa05tNZJfkX3T678icAhTQEbCVQDTM6Uz4mMeTSLd1LWgBWyVTyQPOgElQy0DD8g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"528\" style=\"\" data-recalc-dims=\"1\"><\/p>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;letter-spacing: 0.578px;text-wrap: wrap;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"shell\"><code><span class=\"code-snippet_outer\">rt$futime=rt$futime\/365 #Survival time in years<\/span><\/code><code><span class=\"code-snippet_outer\">rt$tpm=as.numeric(rt$tpm)<\/span><\/code><code><span class=\"code-snippet_outer\">#rt$tissue=as.factor(rt$tissue)<\/span><\/code><\/pre>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.6095238095238096\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_cyianvTxv541emW1AGNRrYvowicLHw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxxXiaZjQfp5iclDXa05tNZJfgEOicDMp5teaVHNramkxpPwGNySicyianvTxv541emW1AGNRrYvowicLHw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"315\" style=\"\" data-recalc-dims=\"1\"><\/p>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;letter-spacing: 0.578px;text-wrap: wrap;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"objectivec\"><code><span class=\"code-snippet_outer\">#######files names<\/span><\/code><code><span class=\"code-snippet_outer\">tmp<- strsplit(dirname,split=\".\",fixed=TRUE)<\/span><\/code><code><span class=\"code-snippet_outer\">dirnam<-unlist(lapply(tmp,head,1))<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">tissue=c(\"ACC\", \"BLCA\", \"BRCA\", \"CESC\", \"CHOL\", \"COAD\", \"DLBC\", \"ESCA\", \"GBM\", \"HNSC\", \"KICH\", \"KIRC\", \"KIRP\", \"LGG\", \"LIHC\", \"LUAD\", \"LUSC\", \"MESO\", \"OV\", \"PAAD\", \"PCPG\", \"PRAD\", \"READ\", \"SARC\", \"SKCM\", \"STAD\", \"TGCT\", \"THCA\", \"THYM\", \"UCEC\", \"UCS\", \"UVM\")<\/span><\/code><code><span class=\"code-snippet_outer\">for ( j in 1:length(tissue) ){<\/span><\/code><code><span class=\"code-snippet_outer\">#for(i in levels(rt[,\"tissue\"] )){<\/span><\/code><code><span class=\"code-snippet_outer\"> id=rt[1,6]<\/span><\/code><code><span class=\"code-snippet_outer\"> cancer=tissue[j]<\/span><\/code><code><span class=\"code-snippet_outer\"> rt1=rt[(rt$tissue %in% cancer),] # by tumour type<\/span><\/code><code><span class=\"code-snippet_outer\">group=ifelse(rt1[,\"tpm\"]>median(rt1[,\"tpm\"]),\"high\",\"low\")<\/span><\/code><code><span class=\"code-snippet_outer\">#\u6839\u636e\u764c\u75c7\u7c7b\u578b\u8fdb\u884c\u5b50\u96c6\u9009\u62e9\uff0c\u5f97\u5230\u7279\u5b9a\u764c\u75c7\u7c7b\u578b\u7684\u6570\u636e\u6846\uff08rt1\uff09\u3002\u7136\u540e\u6839\u636etpm\u7684\u4e2d\u4f4d\u6570\u5c06\u6837\u672c\u5206\u4e3a\u9ad8\u8868\u8fbe\u7ec4\u548c\u4f4e\u8868\u8fbe\u7ec4\uff0c\u521b\u5efa\u4e00\u4e2a\u65b0\u7684\u5217group\u3002\u901a\u8fc7\u5224\u65ad\u662f\u5426\u540c\u65f6\u5305\u542bTRUE\u548cFALSE\u6765\u6392\u9664\u8868\u8fbe\u6c34\u5e73\u76f8\u540c\u7684\u6837\u672c\u7ec4\u3002<\/span><\/code><\/pre>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.1777456647398844\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_rkwPzjqnKwadPibic1UL0T2SQHrjwQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxxXiaZjQfp5iclDXa05tNZJfQAwoCSGZ0ib0FSxlvDcROHG7WaKrkwPzjqnKwadPibic1UL0T2SQHrjwQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"692\" style=\"\" data-recalc-dims=\"1\"><\/p>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;letter-spacing: 0.578px;text-wrap: wrap;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"objectivec\"><code><span class=\"code-snippet_outer\">a=rt1[,\"tpm\"]>median(rt1[,\"tpm\"])<\/span><\/code><code><span class=\"code-snippet_outer\">#\u5982\u679c\u6ee1\u8db3\u6761\u4ef6\uff0c\u63a5\u4e0b\u6765\u8fdb\u884c\u751f\u5b58\u5206\u6790\u3002\u9996\u5148\u4f7f\u7528survdiff\u51fd\u6570\u8fdb\u884c\u7ec4\u95f4\u751f\u5b58\u5dee\u5f02\u7684\u7edf\u8ba1\u68c0\u9a8c\uff0c\u5e76\u8ba1\u7b97p\u503c\u3002\u7136\u540e\u4f7f\u7528survfit\u51fd\u6570\u62df\u5408\u751f\u5b58\u66f2\u7ebf\u3002<\/span><\/code><code><span class=\"code-snippet_outer\"> if(length(table(group))==1) {next}<\/span><\/code><code><span class=\"code-snippet_outer\"> if(TRUE & FALSE %in% a){<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\"> diff=survdiff(Surv(futime,fustat)~ group,data = rt1) #Survival of rt1 data by groups<\/span><\/code><code><span class=\"code-snippet_outer\"> pValue=1-pchisq(diff$chisq,df=1) #test<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\"> fit <- survfit(Surv(futime,fustat) ~ group, data = rt1)<\/span><\/code><code><span class=\"code-snippet_outer\"> #KM survival curves<\/span><\/code><code><span class=\"code-snippet_outer\">#\u63a5\u4e0b\u6765\uff0c\u4f7f\u7528ggsurvplot\u51fd\u6570\u751f\u6210\u751f\u5b58\u66f2\u7ebf\u56fe\u3002\u8fd9\u91cc\u8bbe\u7f6e\u4e86\u56fe\u5f62\u7684\u6807\u9898\u3001p\u503c\u663e\u793a\u3001\u56fe\u4f8b\u3001\u5750\u6807\u8f74\u6807\u7b7e\u7b49\u53c2\u6570\uff0c\u5e76\u4f7f\u7528\u4e0d\u540c\u7684\u989c\u8272\u8868\u793a\u9ad8\u8868\u8fbe\u7ec4\u548c\u4f4e\u8868\u8fbe\u7ec4\u3002<\/span><\/code><code><span class=\"code-snippet_outer\">#\u6700\u540e\uff0c\u5c06\u751f\u6210\u7684\u751f\u5b58\u66f2\u7ebf\u56fe\u4fdd\u5b58\u4e3aPDF\u6587\u4ef6\uff0c\u547d\u540d\u65b9\u5f0f\u4e3a\"\u6587\u4ef6\u540d_\u764c\u75c7\u7c7b\u578b_p\u503c_sur_DFI.pdf\"\u3002<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\"> surPlot=ggsurvplot(fit, <\/span><\/code><code><span class=\"code-snippet_outer\"> data=rt1,<\/span><\/code><code><span class=\"code-snippet_outer\"> title=paste0(\"Cancer: \",cancer=tissue[j]),<\/span><\/code><code><span class=\"code-snippet_outer\"> pval=pValue,<\/span><\/code><code><span class=\"code-snippet_outer\"> pval.size=6,<\/span><\/code><code><span class=\"code-snippet_outer\"> legend.labs=c(\"high\",\"low\"),<\/span><\/code><code><span class=\"code-snippet_outer\"> legend.title=paste0(id,\" levels\"),<\/span><\/code><code><span class=\"code-snippet_outer\"> font.legend=12,<\/span><\/code><code><span class=\"code-snippet_outer\"> xlab=\"Time(years)\",<\/span><\/code><code><span class=\"code-snippet_outer\"> ylab=\"Overall survival\",<\/span><\/code><code><span class=\"code-snippet_outer\"> break.time.by = 1,<\/span><\/code><code><span class=\"code-snippet_outer\"> palette=c(\"red\",\"blue\"),<\/span><\/code><code><span class=\"code-snippet_outer\"> conf.int=F,<\/span><\/code><code><span class=\"code-snippet_outer\"> fontsize=4,<\/span><\/code><code><span class=\"code-snippet_outer\"> risk.table=TRUE,<\/span><\/code><code><span class=\"code-snippet_outer\"> risk.table.title=\"\",<\/span><\/code><code><span class=\"code-snippet_outer\"> risk.table.height=.25)<\/span><\/code><code><span class=\"code-snippet_outer\"> pdf(paste0(\".\/picture_DFI\/\",dirnam,\"_\",cancer=tissue[j],\"_\",pValue, \"_sur_DFI.pdf\"),width = 10, height = 7.5) <\/span><\/code><code><span class=\"code-snippet_outer\"> #ggsave(paste0(\".\/picture_expTime_TG_GTEX\/\",dirnam,\"_\",cancer=tissue[j],\"_\",pValue, \"_sur_os.svg\"), width = 14, height = 15)<\/span><\/code><code><span class=\"code-snippet_outer\"> print(surPlot)<\/span><\/code><code><span class=\"code-snippet_outer\"> dev.off()<\/span><\/code><code><span class=\"code-snippet_outer\"> }<\/span><\/code><code><span class=\"code-snippet_outer\"> }<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">}<\/span><\/code><code><span class=\"code-snippet_outer\">#####<\/span><\/code><\/pre>\n<\/section>\n<\/section>\n<\/section>\n<p><br \/><\/p>\n<p><span style=\"font-size: 14px;\">KM\u66f2\u7ebf\u56fe\u901a\u5e38\u5305\u62ec\u4ee5\u4e0b\u4fe1\u606f\uff1a\u65f6\u95f4\u8f74\uff1a\u8868\u793a\u89c2\u5bdf\u65f6\u95f4\u7684\u6a2a\u8f74\uff0c\u901a\u5e38\u4ee5\u5e74\u3001\u6708\u3001\u5468\u7b49\u4e3a\u5355\u4f4d\u3002\u751f\u5b58\u7387\u8f74\uff1a\u8868\u793a\u751f\u5b58\u60a3\u8005\u7684\u6bd4\u4f8b\uff0c\u7eb5\u8f74\u8303\u56f4\u4ece0\u52301\u3002\u66f2\u7ebf\uff1a\u6bcf\u4e2a\u7ec4\u522b\u7684\u751f\u5b58\u66f2\u7ebf\uff0c\u4ee5\u5b9e\u7ebf\u6216\u865a\u7ebf\u8868\u793a\u3002\u6807\u9898\u548c\u56fe\u4f8b\uff1a\u7528\u4e8e\u6807\u8bc6\u66f2\u7ebf\u5bf9\u5e94\u7684\u7ec4\u522b\u548c\u5176\u4ed6\u91cd\u8981\u4fe1\u606f\u3002<\/span><o:p><\/o:p><\/p>\n<p><span style=\"font-size: 14px;\">\u901a\u8fc7\u7ed8\u5236KM\u66f2\u7ebf\uff0c\u53ef\u4ee5\u76f4\u89c2\u5730\u6bd4\u8f83\u4e0d\u540c\u7ec4\u522b\u4e4b\u95f4\u7684\u751f\u5b58\u5dee\u5f02\uff0c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u548c\u4e34\u5e8a\u533b\u751f\u4e86\u89e3\u67d0\u79cd\u56e0\u7d20\u5bf9\u751f\u5b58\u7684\u5f71\u54cd\uff0c\u4ee5\u6307\u5bfc\u6cbb\u7597\u51b3\u7b56\u548c\u9884\u540e\u8bc4\u4f30\u3002\u6709\u95ee\u9898\u53ef\u4ee5\u8054\u7cfb\u5c0f\u679c\u3002<\/span><o:p><\/o:p><\/p>\n<p><span style=\"font-size: 14px;\">\u6765\u7ed9\u5927\u5bb6\u5c55\u793a\u5c55\u793a\u7ed3\u679c\u56fe\u5427\uff0c\u4f7f\u7528firefox\u547d\u4ee4\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.9746031746031746\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_DgtEpGUOBGobvSNictweJ5fmLpSRxg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxxXiaZjQfp5iclDXa05tNZJfImHXyZ2EuJjNMWNIrzH9AOeplDgtEpGUOBGobvSNictweJ5fmLpSRxg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"315\" style=\"\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.9529780564263323\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_c5G2NUpPpeL0OljGqnibiaQLB3ez6w.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxxXiaZjQfp5iclDXa05tNZJfvDCiaQ3uVxQBtGKk4nJfCvvMefrc5G2NUpPpeL0OljGqnibiaQLB3ez6w\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"319\" style=\"\" data-recalc-dims=\"1\" \/><\/p>\n<p><o:p><\/o:p><\/p>\n<\/section>\n<p><br \/><\/p>\n<section style=\"font-size: 16px;\">\n<p><span style=\"color: rgb(51, 51, 51);font-size: 11.5pt;background: rgb(255, 255, 255);font-family: 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170);\">\u7f51\u5740\uff1ahttp:\/\/www.biocloudservice.com\/home.html<\/span><span style=\"text-align: center;letter-spacing: 0.578px;\"><\/span><\/p>\n<p><br \/><\/p>\n<section data-id=\"75061\" data-type=\"lspecial02\" data-tools=\"\u901f\u6392\u5c0f\u8682\u8681\u7f16\u8f91\u5668\" powered-by=\"xmyeditor.com\" data-md5=\"83a15\">\n<p><span style=\"font-size: 14px;\">\u4eca\u5929\u5c0f\u679c\u7684\u5206\u4eab\u5c31\u5230\u8fd9\u91cc\uff0c\u6b22\u8fce\u5927\u5bb6\u548c\u5c0f\u679c\u4e00\u8d77\u8ba8\u8bba\u5b66\u4e60\uff0c\u4e0b\u671f\u518d\u89c1\u54e6\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;font-size: 14px;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;height: auto;transform: perspective(0px);transform-style: flat;\">\n<section style=\"margin-top: 10px;margin-bottom: 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src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_eVibso6VJox4Hnic0n53VnLS1A9qYA.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAyqVJd7As6iaIgTzXqErqUGpoEpMoWhEkVHHw4z3ZmlYpZZUX7eVibso6VJox4Hnic0n53VnLS1A9qYA\/640?wx_fmt=jpeg&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"jpeg\" data-w=\"900\" style=\"outline: 0px;vertical-align: middle;width: 625px;visibility: visible !important;\" data-recalc-dims=\"1\"><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;text-align: center;line-height: 0;\">\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzAwNjE0MDY3MQ==&mid=2650762044&idx=2&sn=c74f81e91cadd166adc7168dec9891ed&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" 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100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0em;line-height: 1.75em;\"><span style=\"font-size: var(--articleFontsize);letter-spacing: 0.578px;text-align: justify;\"><\/span><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section data-role=\"list\" style=\"\">\n<section powered-by=\"xiumi.us\" style=\"\">\n<section style=\"\">\n<section powered-by=\"xiumi.us\" style=\"\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 8px;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.578px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 16px;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;visibility: visible;\">\n<section style=\"padding-left: 8px;outline: 0px;display: inline-block;width: 578px;vertical-align: top;border-left: 3px solid rgb(219, 219, 219);border-bottom-left-radius: 0px;align-self: flex-start;flex: 0 0 auto;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;color: rgba(0, 0, 0, 0.5);text-align: justify;visibility: visible;\">\n<p style=\"outline: 0px;visibility: visible;\"><span style=\"outline: 0px;font-size: 14px;visibility: visible;\">\u8fd8\u5728\u4e3a\u5982\u4f55\u5165\u95e8\u751f\u4fe1\u800c\u5f77\u5fa8\u5417\uff1f\u8fd8\u5728\u4e3aLinux\u7cfb\u7edf\u800c\u611f\u5230\u65e0\u52a9\u5417\uff1f\u5feb\u5173\u6ce8\u5c0f\u679c\u7684\u5fae\u4fe1\u516c\u4f17\u53f7\uff0c\u5c0f\u679c\u624b\u628a\u624b\u5e26\u4f60\u5165\u95e8\u751f\u4fe1\uff0c\u6ca1\u6709\u95e8\u69db\u3001\u6ca1\u6709\u96be\u5ea6\uff0c\u8ddf\u7740\u6548\u679c\u8d70\uff0c\u5565\u95ee\u9898\u90fd\u6ca1\u6709\u3002<\/span><span style=\"letter-spacing: 0.578px;color: rgba(0, 0, 0, 0.9);font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;font-size: var(--articleFontsize);\"><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p><br \/><\/p>\n<p><span style=\"text-decoration: underline;color: rgb(0, 122, 170);\"><strong><span style=\"text-decoration: underline;font-size: 14px;\">\u751f\u5b58\u5206\u6790\u4e2d\u7684Kaplan-Meier\u66f2\u7ebf\uff08\u4e5f\u79f0\u4e3aKM\u66f2\u7ebf\uff09\u662f\u4e00\u79cd\u5e38\u7528\u7684\u7edf\u8ba1\u65b9\u6cd5<\/span><\/strong><\/span><span style=\"font-size: 14px;\">\uff0c\u7528\u4e8e\u4f30\u8ba1\u4e0d\u540c\u7ec4\u522b\u4e4b\u95f4\u7684\u751f\u5b58\u51fd\u6570\u5dee\u5f02\u3002KM\u66f2\u7ebf\u663e\u793a\u4e86\u5728\u7ed9\u5b9a\u65f6\u95f4\u8303\u56f4\u5185\u751f\u5b58\u4e0b\u6765\u7684\u60a3\u8005\u6bd4\u4f8b\u968f\u65f6\u95f4\u7684\u53d8\u5316\u60c5\u51b5\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\"><br \/><\/span><o:p><\/o:p><\/p>\n<p><span style=\"text-decoration: underline;\"><strong><span style=\"text-decoration: underline;font-size: 14px;color: rgb(0, 122, 170);\">KM\u66f2\u7ebf\u901a\u5e38\u7528\u4e8e\u4ee5\u4e0b\u60c5\u51b5\uff1a<\/span><\/strong><\/span><span style=\"font-size: 14px;\"><\/span><\/p>\n<p><span style=\"font-size: 14px;\"> \u6bd4\u8f83\u4e0d\u540c\u6cbb\u7597\u7ec4\u6216\u6cbb\u7597\u65b9\u6848\u7684\u751f\u5b58\u5dee\u5f02\uff1a\u4f8b\u5982\uff0c\u5bf9\u4e8e\u67d0\u79cd\u764c\u75c7\uff0c\u53ef\u4ee5\u5c06\u60a3\u8005\u5206\u4e3a\u63a5\u53d7\u4e0d\u540c\u6cbb\u7597\u65b9\u6848\u7684\u7ec4\uff0c\u5e76\u6bd4\u8f83\u5404\u7ec4\u7684\u751f\u5b58\u60c5\u51b5\u3002 <\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u8bc4\u4f30\u9884\u540e\u56e0\u7d20\u5bf9\u751f\u5b58\u7684\u5f71\u54cd\uff1a\u4f8b\u5982\uff0c\u7814\u7a76\u7279\u5b9a\u57fa\u56e0\u53d8\u5f02\u4e0e\u60a3\u8005\u751f\u5b58\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u6216\u8005\u8bc4\u4f30\u5176\u4ed6\u4e34\u5e8a\u7279\u5f81\uff08\u5982\u5e74\u9f84\u3001\u6027\u522b\u3001\u80bf\u7624\u5206\u671f\u7b49\uff09\u5bf9\u751f\u5b58\u7684\u5f71\u54cd\u3002<\/span><o:p><\/o:p><\/p>\n<p><span style=\"font-size: 14px;\"><br \/><\/span><\/p>\n<p><span style=\"text-decoration: underline;\"><strong><span style=\"text-decoration: underline;font-size: 14px;color: rgb(0, 122, 170);\">\u7ed8\u5236KM\u66f2\u7ebf\u7684\u6b65\u9aa4\u5982\u4e0b\uff1a<\/span><\/strong><\/span><span style=\"font-size: 14px;\"><\/span><\/p>\n<p><span style=\"font-size: 14px;\"> \u6536\u96c6\u751f\u5b58\u6570\u636e\uff1a\u5305\u62ec\u6bcf\u4e2a\u4e2a\u4f53\u7684\u751f\u5b58\u65f6\u95f4\u548c\u4e8b\u4ef6\u72b6\u6001\uff08\u5982\u751f\u5b58\u6216\u6b7b\u4ea1\uff09\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u6839\u636e\u7814\u7a76\u76ee\u7684\u548c\u53d8\u91cf\u7279\u5f81\uff0c\u5c06\u4e2a\u4f53\u5206\u4e3a\u4e0d\u540c\u7684\u7ec4\u522b\uff08\u4f8b\u5982\u6cbb\u7597\u7ec4\u548c\u5bf9\u7167\u7ec4\uff09\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u4f7f\u7528Kaplan-Meier\u65b9\u6cd5\u8ba1\u7b97\u6bcf\u4e2a\u7ec4\u522b\u4e2d\u5728\u7ed9\u5b9a\u65f6\u95f4\u70b9\u751f\u5b58\u4e0b\u6765\u7684\u60a3\u8005\u6bd4\u4f8b\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u7ed8\u5236KM\u66f2\u7ebf\uff1a\u5c06\u4e0d\u540c\u7ec4\u522b\u5728\u7ed9\u5b9a\u65f6\u95f4\u70b9\u7684\u751f\u5b58\u6bd4\u4f8b\u7ed8\u5236\u5728\u540c\u4e00\u5f20\u56fe\u4e0a\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.578px;\">\u8fdb\u884c\u7edf\u8ba1\u68c0\u9a8c\uff1a<\/span><span style=\"font-size: 14px;letter-spacing: 0.578px;\">\u4f7f\u7528<\/span><span style=\"font-size: 14px;letter-spacing: 0.578px;\">log-rank<\/span><span style=\"font-size: 14px;letter-spacing: 0.578px;\">\u68c0\u9a8c\u6216\u5176\u4ed6\u5408\u9002\u7684\u65b9\u6cd5\u6bd4\u8f83\u4e0d\u540c\u7ec4\u522b\u4e4b\u95f4\u7684\u751f\u5b58\u5dee\u5f02\u3002<\/span><\/p>\n<p><br \/><\/p>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;letter-spacing: 0.578px;text-wrap: wrap;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"css\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">limma<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">survival<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">survminer<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">data<\/span><span class=\"code-snippet__selector-class\">.table<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">tidyverse<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">ggsignif<\/span>) <\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__selector-tag\">library<\/span>(<span class=\"code-snippet__selector-tag\">RColorBrewer<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;outline: 0px;font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<p style=\"text-align: center;\"><br \/><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.578px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"cs\"><code><span class=\"code-snippet_outer\">#\u9996\u5148\uff0c\u52a0\u8f7d\u4e86\u4e00\u7cfb\u5217\u6240\u9700\u7684R\u5305<\/span><\/code><code><span class=\"code-snippet_outer\">files=dir(\".\/DFI\/\")<\/span><\/code><code><span class=\"code-snippet_outer\">\u901a\u8fc7dir(\".\/DFI\/\")\u83b7\u53d6\".\/DFI\/\"\u76ee\u5f55\u4e0b\u7684\u6587\u4ef6\u5217\u8868\uff0c\u8fd9\u4e9b\u6587\u4ef6\u5305\u542b\u4e86\u6bcf\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u751f\u5b58\u6570\u636e\u3002<\/span><\/code><code><span class=\"code-snippet_outer\">pFilter=1 #pvalue ALL DATA,NO filter <\/span><\/code><code><span class=\"code-snippet_outer\">#if(pValue<pFilter){<\/span><\/code><code><span class=\"code-snippet_outer\"> # if(pValue<0.001){<\/span><\/code><code><span class=\"code-snippet_outer\"> # pValue=\"p<0.001\"<\/span><\/code><code><span class=\"code-snippet_outer\"> # }else{<\/span><\/code><code><span class=\"code-snippet_outer\"> # pValue=paste0(\"p=\",sprintf(\"%.03f\",pValue))<\/span><\/code><code><span class=\"code-snippet_outer\"> #}<\/span><\/code><code><span class=\"code-snippet_outer\">#for tumour types<\/span><\/code><code><span class=\"code-snippet_outer\">#\u901a\u8fc7\u4e00\u4e2a\u5faa\u73af\u904d\u5386\u6bcf\u4e2a\u6587\u4ef6\u8fdb\u884c\u5904\u7406\u3002\u5728\u5faa\u73af\u4e2d\uff0c\u9996\u5148\u8bfb\u53d6\u6587\u4ef6\u5185\u5bb9\u5e76\u8f6c\u6362\u4e3a<\/span><\/code><code><span class=\"code-snippet_outer\">#\u6570\u636e\u6846\u3002\u7136\u540e\u5bf9\u6570\u636e\u6846\u8fdb\u884c\u5904\u7406\uff0c\u8c03\u6574\u5217\u540d\u548c\u6570\u636e\u683c\u5f0f\u3002\u5c06\u5b58\u6d3b\u65f6\u95f4\uff08futime\uff09#\u4ece\u5929\u8f6c\u6362\u4e3a\u5e74\uff0c\u5c06tpm\u8f6c\u6362\u4e3a\u6570\u503c\u578b\u6570\u636e\u3002<\/span><\/code><code><span class=\"code-snippet_outer\">for ( i in 1:length(files) ){<\/span><\/code><code><span class=\"code-snippet_outer\"> dirname=files[i]<\/span><\/code><code><span class=\"code-snippet_outer\"> rt=fread(paste0(\".\/DFI\/\",dirname),header=T,check.names=F)<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">rt=as.data.frame.matrix(rt)<\/span><\/code><\/pre>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.19653179190751446\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_Cw6UJ6XhAHHd5s5sEiaGqAXoZR9sDA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxxXiaZjQfp5iclDXa05tNZJfiaS3DvkDHVibWGtt8Ynz2vocJXRCw6UJ6XhAHHd5s5sEiaGqAXoZR9sDA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"692\" style=\"\" data-recalc-dims=\"1\"><\/p>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;letter-spacing: 0.578px;text-wrap: wrap;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"properties\"><code><span class=\"code-snippet_outer\"> #rownames(rt)=rt[,1]<\/span><\/code><code><span class=\"code-snippet_outer\"> rt=rt[,-1]<\/span><\/code><code><span class=\"code-snippet_outer\"> rt=na.omit(rt)<\/span><\/code><code><span class=\"code-snippet_outer\"> colnames(rt)[1:2]=c(\"fustat\",\"futime\")<\/span><\/code><code><span class=\"code-snippet_outer\"> b=rt[,2]<\/span><\/code><code><span class=\"code-snippet_outer\"> rt=cbind(b,rt)<\/span><\/code><code><span class=\"code-snippet_outer\"> rt=rt[,-3]<\/span><\/code><code><span class=\"code-snippet_outer\">colnames(rt)[1]=\"futime\"<\/span><\/code><\/pre>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.26704545454545453\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_mMeTSLd1LWgBWyVTyQPOgElQy0DD8g.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxxXiaZjQfp5iclDXa05tNZJfkX3T678icAhTQEbCVQDTM6Uz4mMeTSLd1LWgBWyVTyQPOgElQy0DD8g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"528\" style=\"\" data-recalc-dims=\"1\"><\/p>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;letter-spacing: 0.578px;text-wrap: wrap;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"shell\"><code><span class=\"code-snippet_outer\">rt$futime=rt$futime\/365 #Survival time in years<\/span><\/code><code><span class=\"code-snippet_outer\">rt$tpm=as.numeric(rt$tpm)<\/span><\/code><code><span class=\"code-snippet_outer\">#rt$tissue=as.factor(rt$tissue)<\/span><\/code><\/pre>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.6095238095238096\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_cyianvTxv541emW1AGNRrYvowicLHw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxxXiaZjQfp5iclDXa05tNZJfgEOicDMp5teaVHNramkxpPwGNySicyianvTxv541emW1AGNRrYvowicLHw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"315\" style=\"\" data-recalc-dims=\"1\"><\/p>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;letter-spacing: 0.578px;text-wrap: wrap;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"objectivec\"><code><span class=\"code-snippet_outer\">#######files names<\/span><\/code><code><span class=\"code-snippet_outer\">tmp<- strsplit(dirname,split=\".\",fixed=TRUE)<\/span><\/code><code><span class=\"code-snippet_outer\">dirnam<-unlist(lapply(tmp,head,1))<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">tissue=c(\"ACC\", \"BLCA\", \"BRCA\", \"CESC\", \"CHOL\", \"COAD\", \"DLBC\", \"ESCA\", \"GBM\", \"HNSC\", \"KICH\", \"KIRC\", \"KIRP\", \"LGG\", \"LIHC\", \"LUAD\", \"LUSC\", \"MESO\", \"OV\", \"PAAD\", \"PCPG\", \"PRAD\", \"READ\", \"SARC\", \"SKCM\", \"STAD\", \"TGCT\", \"THCA\", \"THYM\", \"UCEC\", \"UCS\", \"UVM\")<\/span><\/code><code><span class=\"code-snippet_outer\">for ( j in 1:length(tissue) ){<\/span><\/code><code><span class=\"code-snippet_outer\">#for(i in levels(rt[,\"tissue\"] )){<\/span><\/code><code><span class=\"code-snippet_outer\"> id=rt[1,6]<\/span><\/code><code><span class=\"code-snippet_outer\"> cancer=tissue[j]<\/span><\/code><code><span class=\"code-snippet_outer\"> rt1=rt[(rt$tissue %in% cancer),] # by tumour type<\/span><\/code><code><span class=\"code-snippet_outer\">group=ifelse(rt1[,\"tpm\"]>median(rt1[,\"tpm\"]),\"high\",\"low\")<\/span><\/code><code><span class=\"code-snippet_outer\">#\u6839\u636e\u764c\u75c7\u7c7b\u578b\u8fdb\u884c\u5b50\u96c6\u9009\u62e9\uff0c\u5f97\u5230\u7279\u5b9a\u764c\u75c7\u7c7b\u578b\u7684\u6570\u636e\u6846\uff08rt1\uff09\u3002\u7136\u540e\u6839\u636etpm\u7684\u4e2d\u4f4d\u6570\u5c06\u6837\u672c\u5206\u4e3a\u9ad8\u8868\u8fbe\u7ec4\u548c\u4f4e\u8868\u8fbe\u7ec4\uff0c\u521b\u5efa\u4e00\u4e2a\u65b0\u7684\u5217group\u3002\u901a\u8fc7\u5224\u65ad\u662f\u5426\u540c\u65f6\u5305\u542bTRUE\u548cFALSE\u6765\u6392\u9664\u8868\u8fbe\u6c34\u5e73\u76f8\u540c\u7684\u6837\u672c\u7ec4\u3002<\/span><\/code><\/pre>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.1777456647398844\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_rkwPzjqnKwadPibic1UL0T2SQHrjwQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxxXiaZjQfp5iclDXa05tNZJfQAwoCSGZ0ib0FSxlvDcROHG7WaKrkwPzjqnKwadPibic1UL0T2SQHrjwQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"692\" style=\"\" data-recalc-dims=\"1\"><\/p>\n<section style=\"margin-bottom: 0px;padding-right: 15px;padding-left: 15px;letter-spacing: 0.578px;text-wrap: wrap;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);font-size: 14px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;visibility: visible;\">\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"objectivec\"><code><span class=\"code-snippet_outer\">a=rt1[,\"tpm\"]>median(rt1[,\"tpm\"])<\/span><\/code><code><span class=\"code-snippet_outer\">#\u5982\u679c\u6ee1\u8db3\u6761\u4ef6\uff0c\u63a5\u4e0b\u6765\u8fdb\u884c\u751f\u5b58\u5206\u6790\u3002\u9996\u5148\u4f7f\u7528survdiff\u51fd\u6570\u8fdb\u884c\u7ec4\u95f4\u751f\u5b58\u5dee\u5f02\u7684\u7edf\u8ba1\u68c0\u9a8c\uff0c\u5e76\u8ba1\u7b97p\u503c\u3002\u7136\u540e\u4f7f\u7528survfit\u51fd\u6570\u62df\u5408\u751f\u5b58\u66f2\u7ebf\u3002<\/span><\/code><code><span class=\"code-snippet_outer\"> if(length(table(group))==1) {next}<\/span><\/code><code><span class=\"code-snippet_outer\"> if(TRUE & FALSE %in% a){<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\"> diff=survdiff(Surv(futime,fustat)~ group,data = rt1) #Survival of rt1 data by groups<\/span><\/code><code><span class=\"code-snippet_outer\"> pValue=1-pchisq(diff$chisq,df=1) #test<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\"> fit <- survfit(Surv(futime,fustat) ~ group, data = rt1)<\/span><\/code><code><span class=\"code-snippet_outer\"> #KM survival curves<\/span><\/code><code><span class=\"code-snippet_outer\">#\u63a5\u4e0b\u6765\uff0c\u4f7f\u7528ggsurvplot\u51fd\u6570\u751f\u6210\u751f\u5b58\u66f2\u7ebf\u56fe\u3002\u8fd9\u91cc\u8bbe\u7f6e\u4e86\u56fe\u5f62\u7684\u6807\u9898\u3001p\u503c\u663e\u793a\u3001\u56fe\u4f8b\u3001\u5750\u6807\u8f74\u6807\u7b7e\u7b49\u53c2\u6570\uff0c\u5e76\u4f7f\u7528\u4e0d\u540c\u7684\u989c\u8272\u8868\u793a\u9ad8\u8868\u8fbe\u7ec4\u548c\u4f4e\u8868\u8fbe\u7ec4\u3002<\/span><\/code><code><span class=\"code-snippet_outer\">#\u6700\u540e\uff0c\u5c06\u751f\u6210\u7684\u751f\u5b58\u66f2\u7ebf\u56fe\u4fdd\u5b58\u4e3aPDF\u6587\u4ef6\uff0c\u547d\u540d\u65b9\u5f0f\u4e3a\"\u6587\u4ef6\u540d_\u764c\u75c7\u7c7b\u578b_p\u503c_sur_DFI.pdf\"\u3002<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\"> surPlot=ggsurvplot(fit, <\/span><\/code><code><span class=\"code-snippet_outer\"> data=rt1,<\/span><\/code><code><span class=\"code-snippet_outer\"> title=paste0(\"Cancer: \",cancer=tissue[j]),<\/span><\/code><code><span class=\"code-snippet_outer\"> pval=pValue,<\/span><\/code><code><span class=\"code-snippet_outer\"> pval.size=6,<\/span><\/code><code><span class=\"code-snippet_outer\"> legend.labs=c(\"high\",\"low\"),<\/span><\/code><code><span class=\"code-snippet_outer\"> legend.title=paste0(id,\" levels\"),<\/span><\/code><code><span class=\"code-snippet_outer\"> font.legend=12,<\/span><\/code><code><span class=\"code-snippet_outer\"> xlab=\"Time(years)\",<\/span><\/code><code><span class=\"code-snippet_outer\"> ylab=\"Overall survival\",<\/span><\/code><code><span class=\"code-snippet_outer\"> break.time.by = 1,<\/span><\/code><code><span class=\"code-snippet_outer\"> palette=c(\"red\",\"blue\"),<\/span><\/code><code><span class=\"code-snippet_outer\"> conf.int=F,<\/span><\/code><code><span class=\"code-snippet_outer\"> fontsize=4,<\/span><\/code><code><span class=\"code-snippet_outer\"> risk.table=TRUE,<\/span><\/code><code><span class=\"code-snippet_outer\"> risk.table.title=\"\",<\/span><\/code><code><span class=\"code-snippet_outer\"> risk.table.height=.25)<\/span><\/code><code><span class=\"code-snippet_outer\"> pdf(paste0(\".\/picture_DFI\/\",dirnam,\"_\",cancer=tissue[j],\"_\",pValue, \"_sur_DFI.pdf\"),width = 10, height = 7.5) <\/span><\/code><code><span class=\"code-snippet_outer\"> #ggsave(paste0(\".\/picture_expTime_TG_GTEX\/\",dirnam,\"_\",cancer=tissue[j],\"_\",pValue, \"_sur_os.svg\"), width = 14, height = 15)<\/span><\/code><code><span class=\"code-snippet_outer\"> print(surPlot)<\/span><\/code><code><span class=\"code-snippet_outer\"> dev.off()<\/span><\/code><code><span class=\"code-snippet_outer\"> }<\/span><\/code><code><span class=\"code-snippet_outer\"> }<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">}<\/span><\/code><code><span class=\"code-snippet_outer\">#####<\/span><\/code><\/pre>\n<\/section>\n<\/section>\n<\/section>\n<p><br \/><\/p>\n<p><span style=\"font-size: 14px;\">KM\u66f2\u7ebf\u56fe\u901a\u5e38\u5305\u62ec\u4ee5\u4e0b\u4fe1\u606f\uff1a\u65f6\u95f4\u8f74\uff1a\u8868\u793a\u89c2\u5bdf\u65f6\u95f4\u7684\u6a2a\u8f74\uff0c\u901a\u5e38\u4ee5\u5e74\u3001\u6708\u3001\u5468\u7b49\u4e3a\u5355\u4f4d\u3002\u751f\u5b58\u7387\u8f74\uff1a\u8868\u793a\u751f\u5b58\u60a3\u8005\u7684\u6bd4\u4f8b\uff0c\u7eb5\u8f74\u8303\u56f4\u4ece0\u52301\u3002\u66f2\u7ebf\uff1a\u6bcf\u4e2a\u7ec4\u522b\u7684\u751f\u5b58\u66f2\u7ebf\uff0c\u4ee5\u5b9e\u7ebf\u6216\u865a\u7ebf\u8868\u793a\u3002\u6807\u9898\u548c\u56fe\u4f8b\uff1a\u7528\u4e8e\u6807\u8bc6\u66f2\u7ebf\u5bf9\u5e94\u7684\u7ec4\u522b\u548c\u5176\u4ed6\u91cd\u8981\u4fe1\u606f\u3002<\/span><o:p><\/o:p><\/p>\n<p><span style=\"font-size: 14px;\">\u901a\u8fc7\u7ed8\u5236KM\u66f2\u7ebf\uff0c\u53ef\u4ee5\u76f4\u89c2\u5730\u6bd4\u8f83\u4e0d\u540c\u7ec4\u522b\u4e4b\u95f4\u7684\u751f\u5b58\u5dee\u5f02\uff0c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u548c\u4e34\u5e8a\u533b\u751f\u4e86\u89e3\u67d0\u79cd\u56e0\u7d20\u5bf9\u751f\u5b58\u7684\u5f71\u54cd\uff0c\u4ee5\u6307\u5bfc\u6cbb\u7597\u51b3\u7b56\u548c\u9884\u540e\u8bc4\u4f30\u3002\u6709\u95ee\u9898\u53ef\u4ee5\u8054\u7cfb\u5c0f\u679c\u3002<\/span><o:p><\/o:p><\/p>\n<p><span style=\"font-size: 14px;\">\u6765\u7ed9\u5927\u5bb6\u5c55\u793a\u5c55\u793a\u7ed3\u679c\u56fe\u5427\uff0c\u4f7f\u7528firefox\u547d\u4ee4\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.9746031746031746\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_DgtEpGUOBGobvSNictweJ5fmLpSRxg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxxXiaZjQfp5iclDXa05tNZJfImHXyZ2EuJjNMWNIrzH9AOeplDgtEpGUOBGobvSNictweJ5fmLpSRxg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"315\" style=\"\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.9529780564263323\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_c5G2NUpPpeL0OljGqnibiaQLB3ez6w.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxxXiaZjQfp5iclDXa05tNZJfvDCiaQ3uVxQBtGKk4nJfCvvMefrc5G2NUpPpeL0OljGqnibiaQLB3ez6w\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"319\" style=\"\" data-recalc-dims=\"1\" \/><\/p>\n<p><o:p><\/o:p><\/p>\n<\/section>\n<p><br \/><\/p>\n<section style=\"font-size: 16px;\">\n<p><span style=\"color: rgb(51, 51, 51);font-size: 11.5pt;background: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;\">\u4ee5\u4e0a\u5c31\u662f\u4eca\u5929\u7684\u5185\u5bb9\u5566\uff01<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u4e0b\u671f\u5c06\u4e3a\u4f60\u5e26\u6765\u66f4\u591aR\u8bed\u8a00\u7684\u9a9a\u64cd\u4f5c\u6280\u5de7\uff0c\u5173\u6ce8\u5c0f\u679c\u4e00\u8d77\u5b66\u4e60\u5427\uff01<\/span><span style=\"text-align: center;letter-spacing: 0.578px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14px;\"><br \/><\/span><\/p>\n<p><span style=\"font-size: 14px;color: rgb(0, 122, 170);\">\u8fd9\u91cc\u63a8\u8350\u4e00\u4e0b\u5c0f\u679c\u65b0\u5f00\u53d1\u7684\u96f6\u4ee3\u7801\u4e91\u751f\u4fe1\u5206\u6790\u5de5\u5177\u5e73\u53f0\u5305\u542b\u8d85\u591a\u96f6\u4ee3\u7801\u5c0f\u5de5\u5177\uff0c\u4e0a\u4f20\u6570\u636e\u4e00\u952e\u51fa\u56fe\uff0c\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u4e86\u89e3~<\/span><\/p>\n<p><span style=\"font-size: 14px;color: rgb(0, 122, 170);\">\u7f51\u5740\uff1ahttp:\/\/www.biocloudservice.com\/home.html<\/span><span style=\"text-align: center;letter-spacing: 0.578px;\"><\/span><\/p>\n<p><br \/><\/p>\n<section data-id=\"75061\" data-type=\"lspecial02\" data-tools=\"\u901f\u6392\u5c0f\u8682\u8681\u7f16\u8f91\u5668\" powered-by=\"xmyeditor.com\" data-md5=\"83a15\">\n<p><span style=\"font-size: 14px;\">\u4eca\u5929\u5c0f\u679c\u7684\u5206\u4eab\u5c31\u5230\u8fd9\u91cc\uff0c\u6b22\u8fce\u5927\u5bb6\u548c\u5c0f\u679c\u4e00\u8d77\u8ba8\u8bba\u5b66\u4e60\uff0c\u4e0b\u671f\u518d\u89c1\u54e6\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<section style=\"padding-right: 15px;padding-left: 15px;outline: 0px;font-size: 14px;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;height: auto;transform: perspective(0px);transform-style: flat;\">\n<section style=\"margin-top: 10px;margin-bottom: 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