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inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(340deg) scale(0.65);margin-top: -4px;margin-bottom: -4px;transform-origin: center center;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" 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solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>DCA\uff08Decision Curve Analysis\uff09<\/strong>\u662f\u4e00\u79cd\u66f2\u7ebf\u5206\u6790\u65b9\u6cd5\uff0c\u7528\u4e8e\u8bc4\u4f30\u9884\u6d4b\u6a21\u578b\u7684\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\u3002DCA\u53ef\u4ee5\u5e2e\u52a9\u533b\u5b66\u7814\u7a76\u4eba\u5458\u548c\u4e34\u5e8a\u533b\u751f\u5728\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u4e4b\u95f4\u505a\u51fa\u6700\u4f18\u9009\u62e9\uff0c\u4ee5\u8fbe\u5230\u66f4\u597d\u7684\u4e34\u5e8a\u9884\u6d4b\u6548\u679c\u3002DCA\u53ef\u4ee5\u8bc4\u4f30\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u7684\u6548\u76ca\uff0c\u4f8b\u5982\u764c\u75c7\u7b5b\u67e5\u3001\u75be\u75c5\u9884\u540e\u548c\u836f\u7269\u6cbb\u7597\u7b49\u3002\u5728\u764c\u75c7\u7b5b\u67e5\u4e2d\uff0cDCA\u53ef\u4ee5\u8bc4\u4f30\u4e0d\u540c\u7b5b\u67e5\u6a21\u578b\u7684\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\uff0c\u4ee5\u5e2e\u52a9\u533b\u751f\u5728\u4e0d\u540c\u7b5b\u67e5\u6a21\u578b\u4e4b\u95f4\u505a\u51fa\u6700\u4f18\u9009\u62e9\u3002\u5728\u75be\u75c5\u9884\u540e\u4e2d\uff0cDCA\u53ef\u4ee5\u8bc4\u4f30\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u7684\u5e94\u7528\u4ef7\u503c\uff0c\u4ee5\u5e2e\u52a9\u533b\u751f\u505a\u51fa\u66f4\u51c6\u786e\u7684\u9884\u540e\u9884\u6d4b\u548c\u6cbb\u7597\u51b3\u7b56\u3002<br 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normal;\">\u5728DCA\u4e2d\uff0c\u9996\u5148\u786e\u5b9a\u4e00\u4e2a\u53c2\u8003\u7b56\u7565\u4f5c\u4e3a\u6bd4\u8f83\u57fa\u51c6\uff0c\u4f8b\u5982\u4e0d\u6cbb\u7597\u3001\u5168\u9762\u6cbb\u7597\u7b49\u3002\u7136\u540e\uff0c\u5c06\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u7684\u51b3\u7b56\u66f2\u7ebf\u4e0e\u53c2\u8003\u7b56\u7565\u8fdb\u884c\u6bd4\u8f83\uff0c\u4ee5\u786e\u5b9a\u54ea\u4e2a\u9884\u6d4b\u6a21\u578b\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u5177\u6709\u66f4\u9ad8\u7684\u4e34\u5e8a\u6548\u76ca\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">DCA\u7684\u4f18\u52bf\u5728\u4e8e\u5b83\u4e0d\u4ec5\u8003\u8651\u4e86\u6a21\u578b\u7684\u7075\u654f\u6027\u548c\u7279\u5f02\u6027\uff0c\u8fd8\u8003\u8651\u4e86\u4e0d\u540c\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u6cbb\u7597\u6548\u679c\u548c\u526f\u4f5c\u7528\uff0c\u4ece\u800c\u53ef\u4ee5\u66f4\u5168\u9762\u5730\u8bc4\u4f30\u9884\u6d4b\u6a21\u578b\u7684\u5b9e\u7528\u6027\u548c\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\u3002DCA\u9002\u7528\u4e8e\u8bc4\u4f30\u4efb\u4f55\u7c7b\u578b\u7684\u9884\u6d4b\u6a21\u578b\uff0c\u5305\u62ec\u4e34\u5e8a\u8bc4\u5206\u3001\u751f\u7269\u6807\u5fd7\u7269\u3001\u57fa\u56e0\u7ec4\u5b66\u3001\u86cb\u767d\u7ec4\u5b66\u3001\u5f71\u50cf\u5b66\u7b49\u5404\u79cd\u7c7b\u578b\u7684\u9884\u6d4b\u6a21\u578b\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">DCA\u7684\u539f\u7406\u57fa\u4e8e\u5229\u76ca\uff08Net Benefit\uff09\u7684\u6982\u5ff5\uff0c\u5176\u6838\u5fc3\u601d\u60f3\u662f\u901a\u8fc7\u6bd4\u8f83\u4e0d\u540c\u7edf\u8ba1\u6a21\u578b\u7684\u5229\u76ca\u6765\u9009\u62e9\u6700\u4f73\u6a21\u578b\u3002\u5229\u76ca\u53ef\u4ee5\u5b9a\u4e49\u4e3a\u6cbb\u7597\u6b63\u786e\u7684\u75c5\u4f8b\u6570\u51cf\u53bb\u6cbb\u7597\u9519\u8bef\u7684\u75c5\u4f8b\u6570\uff0c\u5176\u4e2d\u6cbb\u7597\u6b63\u786e\u6307\u7684\u662f\u6839\u636e\u9884\u6d4b\u6a21\u578b\u7684\u8f93\u51fa\u7ed3\u679c\u8fdb\u884c\u6b63\u786e\u7684\u6cbb\u7597\u51b3\u7b56\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u5728DCA\u4e2d\uff0c\u9996\u5148\u9700\u8981\u786e\u5b9a\u4e00\u4e2a\u53c2\u8003\u7b56\u7565\uff0c\u4f8b\u5982\u4e0d\u6cbb\u7597\u6216\u5168\u9762\u6cbb\u7597\u3002\u7136\u540e\uff0c\u5c06\u9884\u6d4b\u6a21\u578b\u7684\u51b3\u7b56\u66f2\u7ebf\u4e0e\u53c2\u8003\u7b56\u7565\u8fdb\u884c\u6bd4\u8f83\uff0c\u4ee5\u786e\u5b9a\u9884\u6d4b\u6a21\u578b\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u4f18\u52a3\u3002\u51b3\u7b56\u66f2\u7ebf\u663e\u793a\u4e86\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\uff0c\u4f7f\u7528\u9884\u6d4b\u6a21\u578b\u8fdb\u884c\u6cbb\u7597\u51b3\u7b56\u6240\u83b7\u5f97\u7684\u5229\u76ca\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u5728DCA\u4e2d\uff0c\u5229\u76ca\u662f\u7531\u56db\u4e2a\u53c2\u6570\u51b3\u5b9a\u7684\uff1a\u9884\u6d4b\u6a21\u578b\u7684\u7075\u654f\u6027\u3001\u7279\u5f02\u6027\u3001\u6cbb\u7597\u6536\u76ca\u548c\u6cbb\u7597\u98ce\u9669\u3002\u5176\u4e2d\uff0c\u7075\u654f\u6027\u548c\u7279\u5f02\u6027\u662f\u9884\u6d4b\u6a21\u578b\u7684\u4e24\u4e2a\u57fa\u672c\u6307\u6807\uff0c\u6cbb\u7597\u6536\u76ca\u548c\u6cbb\u7597\u98ce\u9669\u662f\u6cbb\u7597\u51b3\u7b56\u7684\u4e24\u4e2a\u5173\u952e\u56e0\u7d20\u3002\u5229\u76ca\u53ef\u4ee5\u8868\u793a\u4e3a\u4ee5\u4e0b\u516c\u5f0f\uff1a<\/p>\n<p style=\"white-space: normal;\">Net Benefit = (True Positive Rate \u00d7 Treatment Benefit) – (False Positive Rate \u00d7 Treatment Harm)<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u5176\u4e2d\uff0cTrue Positive Rate\uff08\u771f\u9633\u6027\u7387\uff09\u6307\u7684\u662f\u9884\u6d4b\u6a21\u578b\u6b63\u786e\u5730\u8bc6\u522b\u9700\u8981\u6cbb\u7597\u7684\u75c5\u4f8b\u6570\u5360\u603b\u9700\u8981\u6cbb\u7597\u7684\u75c5\u4f8b\u6570\u7684\u6bd4\u4f8b\uff1bFalse Positive Rate\uff08\u5047\u9633\u6027\u7387\uff09\u6307\u7684\u662f\u9884\u6d4b\u6a21\u578b\u9519\u8bef\u5730\u5c06\u4e0d\u9700\u8981\u6cbb\u7597\u7684\u75c5\u4f8b\u8bc6\u522b\u4e3a\u9700\u8981\u6cbb\u7597\u7684\u75c5\u4f8b\u7684\u6bd4\u4f8b\uff1bTreatment Benefit\uff08\u6cbb\u7597\u6536\u76ca\uff09\u6307\u7684\u662f\u6cbb\u7597\u6b63\u786e\u65f6\u83b7\u5f97\u7684\u5229\u76ca\uff1bTreatment Harm\uff08\u6cbb\u7597\u98ce\u9669\uff09\u6307\u7684\u662f\u6cbb\u7597\u9519\u8bef\u65f6\u9020\u6210\u7684\u635f\u5931\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">DCA\u7684\u76ee\u7684\u662f\u7ed8\u5236\u51b3\u7b56\u66f2\u7ebf\uff0c\u4ee5\u6bd4\u8f83\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u5229\u76ca\u3002\u51b3\u7b56\u66f2\u7ebf\u662f\u5c06\u9884\u6d4b\u6a21\u578b\u7684\u7075\u654f\u6027\u548c\u7279\u5f02\u6027\u4f5c\u4e3a\u6a2a\u8f74\uff0c\u5229\u76ca\u4f5c\u4e3a\u7eb5\u8f74\u7684\u66f2\u7ebf\u3002\u53c2\u8003\u7b56\u7565\u7684\u5229\u76ca\u4e3a0\uff0c\u5373\u5176\u51b3\u7b56\u66f2\u7ebf\u59cb\u7ec8\u4f4d\u4e8ex\u8f74\u4ee5\u4e0b\u3002\u5728DCA\u4e2d\uff0c\u9884\u6d4b\u6a21\u578b\u7684\u51b3\u7b56\u66f2\u7ebf\u8d8a\u9760\u8fd1\u53c2\u8003\u7b56\u7565\u7684\u51b3\u7b56\u66f2\u7ebf\uff0c\u8bf4\u660e\u8be5\u9884\u6d4b\u6a21\u578b\u7684\u4e34\u5e8a\u5b9e\u7528\u6027\u8d8a\u4f4e\u3002\u76f8\u53cd\uff0c\u5982\u679c\u9884\u6d4b\u6a21\u578b\u7684\u51b3\u7b56\u66f2\u7ebf\u5728\u53c2\u8003\u7b56\u7565\u7684\u51b3\u7b56\u66f2\u7ebf\u4e4b\u4e0a\uff0c\u5219\u8bf4\u660e\u8be5\u9884\u6d4b\u6a21\u578b\u7684\u4e34\u5e8a\u5b9e\u7528\u6027\u66f4\u9ad8\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u603b\u7684\u6765\u8bf4\uff0cDCA\u7684\u539f\u7406\u662f\u901a\u8fc7\u5229\u76ca\u6bd4\u8f83\u6765\u9009\u62e9\u6700\u4f73\u9884\u6d4b\u6a21\u578b\uff0c\u5229\u7528\u51b3\u7b56\u66f2\u7ebf\u6765\u6bd4\u8f83\u9884\u6d4b\u6a21\u578b\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u4e34\u5e8a\u6548\u76ca\uff0c\u4ece\u800c\u5e2e\u52a9\u533b\u5b66\u7814\u7a76\u4eba\u5458\u548c\u4e34\u5e8a\u533b\u751f\u5728\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u4e4b\u95f4\u505a\u51fa\u6700\u4f18\u9009\u62e9\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u63a5\u4e0b\u6765\u5c0f\u5e08\u59b9\u5c06\u624b\u628a\u624b\u6559\u4f1a\u5927\u5bb6\u5728R\u4e2d\u4f7f\u7528DCA\uff0c\u8fd9\u91cc\u4e3b\u8981\u4f7f\u7528rmda \u548c ggDCA\u8fd9\u4e24\u4e2a\u5305\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;background-color: rgb(255, 255, 255);overflow: hidden;padding-top: 5px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: center;display: flex;flex-flow: row nowrap;margin-bottom: 5px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(340deg) scale(0.65);margin-top: -4px;margin-bottom: -4px;transform-origin: center center;\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 5px;padding-left: 2px;\">\n<section style=\"text-align: justify;letter-spacing: 2px;color: rgb(239, 135, 135);font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5bfc\u5165\u76f8\u5173\u7684\u5de5\u5177\u5305\u548c\u5185\u7f6e\u6570\u636e\uff1a<\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(20deg);\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">library(rmda)<\/span><\/code><code><span class=\"code-snippet_outer\">library(ggDCA)<\/span><\/code><code><span class=\"code-snippet_outer\">library(ggplot2)<\/span><\/code><code><span class=\"code-snippet_outer\">library(rms)<\/span><\/code><code><span class=\"code-snippet_outer\">library(caret)<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">data(dcaData)<\/span><\/code><code><span class=\"code-snippet_outer\">head(dcaData)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.42048517520215634\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_PEYmotTjlVhGKL3yl6PwUf4Oyv6Ztg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFx74um4bib5CKXf2IuUkmL2gNIWPEYmotTjlVhGKL3yl6PwUf4Oyv6Ztg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"742\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6a21\u578b\u6784\u5efa<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6784\u5efa\u4e00\u4e2a\u5355\u53d8\u91cf\u7684baseline\u6a21\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">set.seed(<span class=\"code-snippet__number\">123<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">baseline.model <- decision_curve(Cancer ~ Age + Female + Smokes, data = dcaData,<\/span><\/code><code><span class=\"code-snippet_outer\">thresholds = seq(<span class=\"code-snippet__number\">0<\/span>, <span class=\"code-snippet__number\">0.4<\/span>, by = <span class=\"code-snippet__number\">0.005<\/span>), bootstraps = <span class=\"code-snippet__number\">10<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">plot_decision_curve(baseline.model,<\/span><\/code><code><span class=\"code-snippet_outer\">curve.names = <span class=\"code-snippet__string\">\"Baseline Model\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">cost.benefit.axis =<span class=\"code-snippet__literal\">FALSE<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#col= c('red','blue'),<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">confidence.intervals=<span class=\"code-snippet__literal\">FALSE<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">standardize = <span class=\"code-snippet__literal\">FALSE<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.5444444444444444\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_oC4y2NXicianTzFAJdwiaScWHjHuGA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxaJkjh7S3MIfM7MheEW0e8qPqVIUoC4y2NXicianTzFAJdwiaScWHjHuGA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u6ce8\u610f\uff0c\u8fd9\u91cc”all”\u548c”none”\u662f\u4e24\u79cd\u53c2\u8003\u7b56\u7565\uff0c\u7528\u4e8e\u6bd4\u8f83\u9884\u6d4b\u6a21\u578b\u7684\u6548\u76ca\u3002”all”\u53c2\u8003\u7b56\u7565\u610f\u5473\u7740\u5728\u6240\u6709\u60c5\u51b5\u4e0b\u90fd\u8fdb\u884c\u6cbb\u7597\uff0c\u800c”none”\u53c2\u8003\u7b56\u7565\u610f\u5473\u7740\u4e0d\u8fdb\u884c\u6cbb\u7597\u3002\u8fd9\u4e24\u79cd\u53c2\u8003\u7b56\u7565\u7684\u76ee\u7684\u662f\u5e2e\u52a9\u8bc4\u4f30\u9884\u6d4b\u6a21\u578b\u7684\u6548\u76ca\u548c\u4e34\u5e8a\u5b9e\u7528\u6027\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u5728DCA\u7684\u56fe\u50cf\u4e2d\uff0c\u53c2\u8003\u7b56\u7565\u7684\u6548\u76ca\u59cb\u7ec8\u4e3a0\u3002\u9884\u6d4b\u6a21\u578b\u7684\u6548\u76ca\u66f2\u7ebf\u4e0e\u53c2\u8003\u7b56\u7565\u7684\u6548\u76ca\u66f2\u7ebf\u8fdb\u884c\u6bd4\u8f83\uff0c\u4ee5\u786e\u5b9a\u9884\u6d4b\u6a21\u578b\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u4e34\u5e8a\u6548\u76ca\u3002\u5982\u679c\u9884\u6d4b\u6a21\u578b\u7684\u6548\u76ca\u66f2\u7ebf\u5728\u53c2\u8003\u7b56\u7565\u7684\u6548\u76ca\u66f2\u7ebf\u4e4b\u4e0a\uff0c\u5219\u8bf4\u660e\u8be5\u9884\u6d4b\u6a21\u578b\u5728\u8be5\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u5177\u6709\u4e34\u5e8a\u5b9e\u7528\u6027\u3002\u5982\u679c\u9884\u6d4b\u6a21\u578b\u7684\u6548\u76ca\u66f2\u7ebf\u5728\u53c2\u8003\u7b56\u7565\u7684\u6548\u76ca\u66f2\u7ebf\u4e4b\u4e0b\uff0c\u5219\u8bf4\u660e\u8be5\u9884\u6d4b\u6a21\u578b\u5728\u8be5\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u6ca1\u6709\u4e34\u5e8a\u5b9e\u7528\u6027\u3002<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6784\u9020\u4e00\u4e2a\u5168\u53d8\u91cf\u6a21\u578b\uff0c\u53ca\u5c06\u5176\u4ed6\u5269\u4f59\u7684\u53d8\u91cf\u90fd\u52a0\u5165\u6a21\u578b\u4e2d\uff0c\u6784\u5efa\u9884\u6d4b\u6a21\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">set.seed(<span class=\"code-snippet__number\">123<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">full.model <- decision_curve(Cancer~Age + Female + Smokes + Marker1 + Marker2,<\/span><\/code><code><span class=\"code-snippet_outer\">data = dcaData,<\/span><\/code><code><span class=\"code-snippet_outer\">thresholds = seq(<span class=\"code-snippet__number\">0<\/span>, <span class=\"code-snippet__number\">.4<\/span>, by = <span class=\"code-snippet__number\">.005<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\">bootstraps = <span class=\"code-snippet__number\">10<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">plot_decision_curve(full.model,<\/span><\/code><code><span class=\"code-snippet_outer\">curve.names = <span class=\"code-snippet__string\">\"Full Model\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">cost.benefit.axis =<span class=\"code-snippet__literal\">FALSE<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#col= c('red','blue'),<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">confidence.intervals=<span class=\"code-snippet__literal\">FALSE<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">standardize = <span class=\"code-snippet__literal\">FALSE<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5509259259259259\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_yt0VogSH35xHicVTEvPviajSgoLiaQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxu7lf9t8v5SdCzV2Tw73RnAhlU1icyt0VogSH35xHicVTEvPviajSgoLiaQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5bf9\u6bd4\u6a21\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">plot_decision_curve(<span class=\"code-snippet__built_in\">list<\/span>(baseline.model, full.model), curve.names = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"Baseline model\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__string\">\"Full model\"<\/span>), col = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"blue\"<\/span>, <span class=\"code-snippet__string\">\"red\"<\/span>), lty = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__number\">1<\/span>, <span class=\"code-snippet__number\">2<\/span>), lwd = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__number\">3<\/span>, <span class=\"code-snippet__number\">2<\/span>, <span class=\"code-snippet__number\">2<\/span>, <span class=\"code-snippet__number\">1<\/span>), legend.position = <span class=\"code-snippet__string\">\"bottomright\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5416666666666666\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_9c2ujr9T7nwFM1cjxlVtibLy40ygCQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxeKSF0NBeu3xX6us5Je7paBpbC9c2ujr9T7nwFM1cjxlVtibLy40ygCQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u56fe\u4e2d\uff0ccost-benefit\u8f74\u662f\u6307\u6a2a\u8f74\u548c\u7eb5\u8f74\u7684\u6bd4\u4f8b\u5c3a\u3002\u5728\u8fd9\u4e2a\u8f74\u4e0a\uff0c\u6a2a\u8f74\u8868\u793a\u6cbb\u7597\u51b3\u7b56\u7684\u9608\u503c\u6216\u6982\u7387\u9608\u503c\uff0c\u7eb5\u8f74\u8868\u793a\u51b3\u7b56\u6536\u76ca\uff0c\u4e5f\u79f0\u4e3a\u51c0\u83b7\u5229\uff08net benefit\uff09\u6216\u51c0\u6548\u76ca\uff08net benefit\uff09\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">cost-benefit\u8f74\u7684\u6bd4\u4f8b\u5c3a\u662f\u6839\u636e\u4e34\u5e8a\u51b3\u7b56\u7684\u6210\u672c\u548c\u6548\u76ca\u8fdb\u884c\u9009\u62e9\u7684\u3002\u6210\u672c\u53ef\u4ee5\u662f\u6cbb\u7597\u6210\u672c\u3001\u6d4b\u8bd5\u6210\u672c\u3001\u65f6\u95f4\u6210\u672c\u7b49\uff0c\u800c\u6548\u76ca\u53ef\u4ee5\u662f\u6cbb\u6108\u7387\u3001\u751f\u5b58\u7387\u3001\u75bc\u75db\u51cf\u8f7b\u7a0b\u5ea6\u7b49\u3002\u901a\u8fc7\u5c06\u6cbb\u7597\u6210\u672c\u548c\u6548\u76ca\u8003\u8651\u5728\u5185\uff0c\u53ef\u4ee5\u786e\u5b9a\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u6700\u4f18\u7b56\u7565\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u63a5\u4e0b\u6765\u518d\u770b\u770bggDCA\u5de5\u5177\u5305\u5982\u4f55\u7ed8\u5236DCA<\/strong><\/p>\n<\/section>\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;background-color: rgb(255, 255, 255);overflow: hidden;padding-top: 5px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: center;display: flex;flex-flow: row nowrap;margin-bottom: 5px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(340deg) scale(0.65);margin-top: -4px;margin-bottom: -4px;transform-origin: center center;\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 5px;padding-left: 2px;\">\n<section style=\"text-align: justify;letter-spacing: 2px;color: rgb(239, 135, 135);font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5bfc\u5165\u5185\u7f6e\u6570\u636e<\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(20deg);\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">data(LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">ddist <- datadist(LIRI) <span class=\"code-snippet__comment\">###\u6253\u5305\u6570\u636e<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">options(datadist = <span class=\"code-snippet__string\">\"ddist\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>ggDCA \u4e2ddca\u53ef\u4ee5\u5b8c\u6210\u5355\u4e2a\u6216\u591a\u4e2a\u6a21\u578b\u7684DCA\u66f2\u7ebf\u7ed8\u5236\uff0c\u6a21\u578b\u5bf9\u8c61\u5305\u62ec\u56db\u4e2a\uff1a<\/strong><\/p>\n<ul class=\"list-paddingleft-1\" style=\"padding-left: 40px;list-style-position: outside;\">\n<li>\n<p>coxph (Cox \u6bd4\u4f8b\u98ce\u9669\u56de\u5f52\u6a21\u578b,Fit Proportional Hazards Regression Model)<\/p>\n<\/li>\n<li>\n<p>cph (Cox \u6bd4\u4f8b\u98ce\u9669\u56de\u5f52\u6a21\u578b,Cox Proportional Hazards Model and Extensions)<\/p>\n<\/li>\n<li>\n<p>glm (\u5e7f\u4e49\u7ebf\u578b\u6a21\u578b,Fitting Generalized Linear Models\uff09<\/p>\n<\/li>\n<li>\n<p>lrm (\u903b\u8f91\u56de\u5f52\u6a21\u578b,Logistic Regression Model)<\/p>\n<\/li>\n<\/ul>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u540c\u65f6\u8fd8\u53ef\u4ee5\u8bbe\u7f6e\u4e0d\u540c\u65f6\u671f\u7684\u9884\u6d4b\u6548\u679c\uff0c\u4e5f\u53ef\u4ee5\u5728\u9a8c\u8bc1\u96c6\u91cc\u9762\u8fdb\u884c\u9a8c\u8bc1\u3002<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6784\u5efaLogistic\u56de\u5f52\u6a21\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6839\u636e\u4e0d\u540c\u60c5\u51b5\uff0c\u6dfb\u52a0\u53d8\u91cf\u5373\u4e3a\u57fa\u56e0\u7684\u4e2a\u6570\uff0c\u6784\u5efa\u56db\u4e2a\u4e0d\u540c\u53d8\u91cf\u7684Logistic \u56de\u5f52\u6a21\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">lrm1 <- lrm(status ~ ANLN, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">lrm2 <- lrm(status ~ ANLN + CENPA, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">lrm3 <- lrm(status ~ ANLN + CENPA + GPR182, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">lrm4 <- lrm(status ~ ANLN + CENPA + GPR182 + BCO2, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u67e5\u770b\u7ed3\u679c\uff0c\u5305\u62ec\u9608\u503c\uff0c\u771f\u9633\u6027\uff0c\u5047\u9633\u6027\uff0c\u51c0\u6536\u76ca<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">dca_lrm <- dca(lrm1, lrm2, lrm3, lrm4, model.names = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"ANLN\"<\/span>, <span class=\"code-snippet__string\">\"ANLN+CENPA\"<\/span>, <span class=\"code-snippet__string\">\"ANLN+CENPA+GPR182\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__string\">\"ANLN+CENPA+GPR182+BCO2\"<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">head(dca_lrm)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.33910891089108913\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_AuGeBPrlscAmjfDj1o1Ov8HoqCAsLQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxoTgPSnzKWCD4bXJUVEVAZrUzAuGeBPrlscAmjfDj1o1Ov8HoqCAsLQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"808\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u7ed8\u5236\uff0c\u5bf9\u6bd4\u4e0d\u540c\u6a21\u578b\u7684DCA\u66f2\u7ebf<br \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">ggplot(dca_lrm, lwd = <span class=\"code-snippet__number\">0.5<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5787037037037037\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_a8RGWJGky996O1fdJKDjgvgbZE6gUg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxLUb4sJP8HibZUKP4Cej57QpXnia8RGWJGky996O1fdJKDjgvgbZE6gUg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u63a5\u4e0b\u6765\u770b\u4e00\u4e0b\u5982\u679c\u662f\u6784\u5efaCOX\u56de\u5f52\u7684\u60c5\u51b5\uff0c\u6b65\u9aa4\u975e\u5e38\u7684\u76f8\u4f3c\uff0c\u4f46\u662f\u6ce8\u610f\u8981\u5bfc\u5165\u4e00\u4e0bsurvival\u5305\uff1a<br \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">library(survival)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6784\u5efaCox\u56de\u5f52\u6a21\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">cph1 <- cph(Surv(time, status) ~ ANLN, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">cph2 <- cph(Surv(time, status) ~ ANLN + CENPA, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">cph3 <- cph(Surv(time, status) ~ ANLN + CENPA + GPR182, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">cph4 <- cph(Surv(time, status) ~ ANLN + CENPA + GPR182 + BCO2, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">dca_cph <- dca(cph1, cph2, cph3, cph4, model.names = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"ANLN\"<\/span>, <span class=\"code-snippet__string\">\"ANLN+CENPA\"<\/span>, <span class=\"code-snippet__string\">\"ANLN+CENPA+GPR182\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__string\">\"ANLN+CENPA+GPR182+BCO2\"<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">head(dca_cph)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.30666666666666664\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_ELYsbeFfwZ4AxiaCX3VSt5UbAMmQtg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxiad6F1vPzcrxPVvOb7gPrnRPjEELYsbeFfwZ4AxiaCX3VSt5UbAMmQtg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"900\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">ggplot(dca_cph, lwd = <span class=\"code-snippet__number\">0.5<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5796296296296296\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_rP0lmK9dWPx2LHz288ZjvOu54MgYmQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxGLW1oTfmzCsX2DFyu7AMZk1xrP0lmK9dWPx2LHz288ZjvOu54MgYmQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: 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{"id":57228,"date":"2024-06-16T18:59:23","date_gmt":"2024-06-16T10:59:23","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=57228"},"modified":"2024-06-16T18:59:23","modified_gmt":"2024-06-16T10:59:23","slug":"%e4%b8%b4%e5%ba%8a%e5%88%86%e6%9e%90%e4%bd%a0%e4%b8%8d%e8%83%bd%e4%b8%8d%e4%bc%9a%e7%9a%84%e6%8a%80%e8%83%bd%e4%b9%8bdca%e5%86%b3%e7%ad%96%e6%9b%b2%e7%ba%bf%e5%88%86%e6%9e%90","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=57228","title":{"rendered":"\u4e34\u5e8a\u5206\u6790\u4f60\u4e0d\u80fd\u4e0d\u4f1a\u7684\u6280\u80fd\u4e4bDCA\u51b3\u7b56\u66f2\u7ebf\u5206\u6790"},"content":{"rendered":"

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weui-wa-hotarea\" id=\"js_name\">\u751f\u4fe1\u679c <\/a><\/span><em id=\"publish_time\" class=\"rich_media_meta rich_media_meta_text\">2023-08-25 19:01:19<\/em><\/div>\n<p><content><\/p>\n<div class=\"reprint\">\n<p>\u8f6c\u81ea\u516c\u4f17\u53f7\uff1aR\u8bed\u8a00\u5b66\u5f92<br \/><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg5MDk3Mzg4OA==&mid=2247485000&idx=1&sn=5dd6adf2e2d124d203bfe9e9dd521894\" target=\"_blank\" title=\"\u9605\u8bfb\u539f\u6587\" rel=\"noopener\">http:\/\/mp.weixin.qq.com\/s?__biz=Mzg5MDk3Mzg4OA==&mid=2247485000&idx=1&sn=5dd6adf2e2d124d203bfe9e9dd521894<\/a><\/p>\n<\/div>\n<section style=\"font-size: 16px;margin-bottom: 24px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(340deg) scale(0.65);margin-top: -4px;margin-bottom: -4px;transform-origin: center center;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 5px;padding-left: 2px;\">\n<section style=\"text-align: justify;color: rgb(239, 135, 135);font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"text-align: center;white-space: normal;\"><span style=\"font-size: 16px;\">\u70b9\u51fb\u84dd\u5b57\uff0c\u5173\u6ce8\u6211\u4eec<\/span><br \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(20deg);\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>DCA\uff08Decision Curve Analysis\uff09<\/strong>\u662f\u4e00\u79cd\u66f2\u7ebf\u5206\u6790\u65b9\u6cd5\uff0c\u7528\u4e8e\u8bc4\u4f30\u9884\u6d4b\u6a21\u578b\u7684\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\u3002DCA\u53ef\u4ee5\u5e2e\u52a9\u533b\u5b66\u7814\u7a76\u4eba\u5458\u548c\u4e34\u5e8a\u533b\u751f\u5728\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u4e4b\u95f4\u505a\u51fa\u6700\u4f18\u9009\u62e9\uff0c\u4ee5\u8fbe\u5230\u66f4\u597d\u7684\u4e34\u5e8a\u9884\u6d4b\u6548\u679c\u3002DCA\u53ef\u4ee5\u8bc4\u4f30\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u7684\u6548\u76ca\uff0c\u4f8b\u5982\u764c\u75c7\u7b5b\u67e5\u3001\u75be\u75c5\u9884\u540e\u548c\u836f\u7269\u6cbb\u7597\u7b49\u3002\u5728\u764c\u75c7\u7b5b\u67e5\u4e2d\uff0cDCA\u53ef\u4ee5\u8bc4\u4f30\u4e0d\u540c\u7b5b\u67e5\u6a21\u578b\u7684\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\uff0c\u4ee5\u5e2e\u52a9\u533b\u751f\u5728\u4e0d\u540c\u7b5b\u67e5\u6a21\u578b\u4e4b\u95f4\u505a\u51fa\u6700\u4f18\u9009\u62e9\u3002\u5728\u75be\u75c5\u9884\u540e\u4e2d\uff0cDCA\u53ef\u4ee5\u8bc4\u4f30\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u7684\u5e94\u7528\u4ef7\u503c\uff0c\u4ee5\u5e2e\u52a9\u533b\u751f\u505a\u51fa\u66f4\u51c6\u786e\u7684\u9884\u540e\u9884\u6d4b\u548c\u6cbb\u7597\u51b3\u7b56\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">DCA\u7684\u6838\u5fc3\u601d\u60f3\u662f\u901a\u8fc7\u7ed8\u5236\u51b3\u7b56\u66f2\u7ebf\u6765\u6bd4\u8f83\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u4e34\u5e8a\u6548\u76ca\u3002\u51b3\u7b56\u66f2\u7ebf\u663e\u793a\u4e86\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\uff0c\u4f7f\u7528\u9884\u6d4b\u6a21\u578b\u8fdb\u884c\u6cbb\u7597\u51b3\u7b56\u6240\u83b7\u5f97\u7684\u5229\u76ca\u3002\u5229\u76ca\u53ef\u4ee5\u5b9a\u4e49\u4e3a\u6cbb\u7597\u6b63\u786e\u7684\u75c5\u4f8b\u6570\u51cf\u53bb\u6cbb\u7597\u9519\u8bef\u7684\u75c5\u4f8b\u6570\uff0c\u5176\u4e2d\u6cbb\u7597\u6b63\u786e\u6307\u7684\u662f\u6839\u636e\u9884\u6d4b\u6a21\u578b\u7684\u8f93\u51fa\u7ed3\u679c\u8fdb\u884c\u6b63\u786e\u7684\u6cbb\u7597\u51b3\u7b56\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u5728DCA\u4e2d\uff0c\u9996\u5148\u786e\u5b9a\u4e00\u4e2a\u53c2\u8003\u7b56\u7565\u4f5c\u4e3a\u6bd4\u8f83\u57fa\u51c6\uff0c\u4f8b\u5982\u4e0d\u6cbb\u7597\u3001\u5168\u9762\u6cbb\u7597\u7b49\u3002\u7136\u540e\uff0c\u5c06\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u7684\u51b3\u7b56\u66f2\u7ebf\u4e0e\u53c2\u8003\u7b56\u7565\u8fdb\u884c\u6bd4\u8f83\uff0c\u4ee5\u786e\u5b9a\u54ea\u4e2a\u9884\u6d4b\u6a21\u578b\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u5177\u6709\u66f4\u9ad8\u7684\u4e34\u5e8a\u6548\u76ca\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">DCA\u7684\u4f18\u52bf\u5728\u4e8e\u5b83\u4e0d\u4ec5\u8003\u8651\u4e86\u6a21\u578b\u7684\u7075\u654f\u6027\u548c\u7279\u5f02\u6027\uff0c\u8fd8\u8003\u8651\u4e86\u4e0d\u540c\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u6cbb\u7597\u6548\u679c\u548c\u526f\u4f5c\u7528\uff0c\u4ece\u800c\u53ef\u4ee5\u66f4\u5168\u9762\u5730\u8bc4\u4f30\u9884\u6d4b\u6a21\u578b\u7684\u5b9e\u7528\u6027\u548c\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c\u3002DCA\u9002\u7528\u4e8e\u8bc4\u4f30\u4efb\u4f55\u7c7b\u578b\u7684\u9884\u6d4b\u6a21\u578b\uff0c\u5305\u62ec\u4e34\u5e8a\u8bc4\u5206\u3001\u751f\u7269\u6807\u5fd7\u7269\u3001\u57fa\u56e0\u7ec4\u5b66\u3001\u86cb\u767d\u7ec4\u5b66\u3001\u5f71\u50cf\u5b66\u7b49\u5404\u79cd\u7c7b\u578b\u7684\u9884\u6d4b\u6a21\u578b\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">DCA\u7684\u539f\u7406\u57fa\u4e8e\u5229\u76ca\uff08Net Benefit\uff09\u7684\u6982\u5ff5\uff0c\u5176\u6838\u5fc3\u601d\u60f3\u662f\u901a\u8fc7\u6bd4\u8f83\u4e0d\u540c\u7edf\u8ba1\u6a21\u578b\u7684\u5229\u76ca\u6765\u9009\u62e9\u6700\u4f73\u6a21\u578b\u3002\u5229\u76ca\u53ef\u4ee5\u5b9a\u4e49\u4e3a\u6cbb\u7597\u6b63\u786e\u7684\u75c5\u4f8b\u6570\u51cf\u53bb\u6cbb\u7597\u9519\u8bef\u7684\u75c5\u4f8b\u6570\uff0c\u5176\u4e2d\u6cbb\u7597\u6b63\u786e\u6307\u7684\u662f\u6839\u636e\u9884\u6d4b\u6a21\u578b\u7684\u8f93\u51fa\u7ed3\u679c\u8fdb\u884c\u6b63\u786e\u7684\u6cbb\u7597\u51b3\u7b56\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u5728DCA\u4e2d\uff0c\u9996\u5148\u9700\u8981\u786e\u5b9a\u4e00\u4e2a\u53c2\u8003\u7b56\u7565\uff0c\u4f8b\u5982\u4e0d\u6cbb\u7597\u6216\u5168\u9762\u6cbb\u7597\u3002\u7136\u540e\uff0c\u5c06\u9884\u6d4b\u6a21\u578b\u7684\u51b3\u7b56\u66f2\u7ebf\u4e0e\u53c2\u8003\u7b56\u7565\u8fdb\u884c\u6bd4\u8f83\uff0c\u4ee5\u786e\u5b9a\u9884\u6d4b\u6a21\u578b\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u4f18\u52a3\u3002\u51b3\u7b56\u66f2\u7ebf\u663e\u793a\u4e86\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\uff0c\u4f7f\u7528\u9884\u6d4b\u6a21\u578b\u8fdb\u884c\u6cbb\u7597\u51b3\u7b56\u6240\u83b7\u5f97\u7684\u5229\u76ca\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u5728DCA\u4e2d\uff0c\u5229\u76ca\u662f\u7531\u56db\u4e2a\u53c2\u6570\u51b3\u5b9a\u7684\uff1a\u9884\u6d4b\u6a21\u578b\u7684\u7075\u654f\u6027\u3001\u7279\u5f02\u6027\u3001\u6cbb\u7597\u6536\u76ca\u548c\u6cbb\u7597\u98ce\u9669\u3002\u5176\u4e2d\uff0c\u7075\u654f\u6027\u548c\u7279\u5f02\u6027\u662f\u9884\u6d4b\u6a21\u578b\u7684\u4e24\u4e2a\u57fa\u672c\u6307\u6807\uff0c\u6cbb\u7597\u6536\u76ca\u548c\u6cbb\u7597\u98ce\u9669\u662f\u6cbb\u7597\u51b3\u7b56\u7684\u4e24\u4e2a\u5173\u952e\u56e0\u7d20\u3002\u5229\u76ca\u53ef\u4ee5\u8868\u793a\u4e3a\u4ee5\u4e0b\u516c\u5f0f\uff1a<\/p>\n<p style=\"white-space: normal;\">Net Benefit = (True Positive Rate \u00d7 Treatment Benefit) – (False Positive Rate \u00d7 Treatment Harm)<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u5176\u4e2d\uff0cTrue Positive Rate\uff08\u771f\u9633\u6027\u7387\uff09\u6307\u7684\u662f\u9884\u6d4b\u6a21\u578b\u6b63\u786e\u5730\u8bc6\u522b\u9700\u8981\u6cbb\u7597\u7684\u75c5\u4f8b\u6570\u5360\u603b\u9700\u8981\u6cbb\u7597\u7684\u75c5\u4f8b\u6570\u7684\u6bd4\u4f8b\uff1bFalse Positive Rate\uff08\u5047\u9633\u6027\u7387\uff09\u6307\u7684\u662f\u9884\u6d4b\u6a21\u578b\u9519\u8bef\u5730\u5c06\u4e0d\u9700\u8981\u6cbb\u7597\u7684\u75c5\u4f8b\u8bc6\u522b\u4e3a\u9700\u8981\u6cbb\u7597\u7684\u75c5\u4f8b\u7684\u6bd4\u4f8b\uff1bTreatment Benefit\uff08\u6cbb\u7597\u6536\u76ca\uff09\u6307\u7684\u662f\u6cbb\u7597\u6b63\u786e\u65f6\u83b7\u5f97\u7684\u5229\u76ca\uff1bTreatment Harm\uff08\u6cbb\u7597\u98ce\u9669\uff09\u6307\u7684\u662f\u6cbb\u7597\u9519\u8bef\u65f6\u9020\u6210\u7684\u635f\u5931\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">DCA\u7684\u76ee\u7684\u662f\u7ed8\u5236\u51b3\u7b56\u66f2\u7ebf\uff0c\u4ee5\u6bd4\u8f83\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u5229\u76ca\u3002\u51b3\u7b56\u66f2\u7ebf\u662f\u5c06\u9884\u6d4b\u6a21\u578b\u7684\u7075\u654f\u6027\u548c\u7279\u5f02\u6027\u4f5c\u4e3a\u6a2a\u8f74\uff0c\u5229\u76ca\u4f5c\u4e3a\u7eb5\u8f74\u7684\u66f2\u7ebf\u3002\u53c2\u8003\u7b56\u7565\u7684\u5229\u76ca\u4e3a0\uff0c\u5373\u5176\u51b3\u7b56\u66f2\u7ebf\u59cb\u7ec8\u4f4d\u4e8ex\u8f74\u4ee5\u4e0b\u3002\u5728DCA\u4e2d\uff0c\u9884\u6d4b\u6a21\u578b\u7684\u51b3\u7b56\u66f2\u7ebf\u8d8a\u9760\u8fd1\u53c2\u8003\u7b56\u7565\u7684\u51b3\u7b56\u66f2\u7ebf\uff0c\u8bf4\u660e\u8be5\u9884\u6d4b\u6a21\u578b\u7684\u4e34\u5e8a\u5b9e\u7528\u6027\u8d8a\u4f4e\u3002\u76f8\u53cd\uff0c\u5982\u679c\u9884\u6d4b\u6a21\u578b\u7684\u51b3\u7b56\u66f2\u7ebf\u5728\u53c2\u8003\u7b56\u7565\u7684\u51b3\u7b56\u66f2\u7ebf\u4e4b\u4e0a\uff0c\u5219\u8bf4\u660e\u8be5\u9884\u6d4b\u6a21\u578b\u7684\u4e34\u5e8a\u5b9e\u7528\u6027\u66f4\u9ad8\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u603b\u7684\u6765\u8bf4\uff0cDCA\u7684\u539f\u7406\u662f\u901a\u8fc7\u5229\u76ca\u6bd4\u8f83\u6765\u9009\u62e9\u6700\u4f73\u9884\u6d4b\u6a21\u578b\uff0c\u5229\u7528\u51b3\u7b56\u66f2\u7ebf\u6765\u6bd4\u8f83\u9884\u6d4b\u6a21\u578b\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u4e34\u5e8a\u6548\u76ca\uff0c\u4ece\u800c\u5e2e\u52a9\u533b\u5b66\u7814\u7a76\u4eba\u5458\u548c\u4e34\u5e8a\u533b\u751f\u5728\u4e0d\u540c\u9884\u6d4b\u6a21\u578b\u4e4b\u95f4\u505a\u51fa\u6700\u4f18\u9009\u62e9\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u63a5\u4e0b\u6765\u5c0f\u5e08\u59b9\u5c06\u624b\u628a\u624b\u6559\u4f1a\u5927\u5bb6\u5728R\u4e2d\u4f7f\u7528DCA\uff0c\u8fd9\u91cc\u4e3b\u8981\u4f7f\u7528rmda \u548c ggDCA\u8fd9\u4e24\u4e2a\u5305\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;background-color: rgb(255, 255, 255);overflow: hidden;padding-top: 5px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: center;display: flex;flex-flow: row nowrap;margin-bottom: 5px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(340deg) scale(0.65);margin-top: -4px;margin-bottom: -4px;transform-origin: center center;\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 5px;padding-left: 2px;\">\n<section style=\"text-align: justify;letter-spacing: 2px;color: rgb(239, 135, 135);font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5bfc\u5165\u76f8\u5173\u7684\u5de5\u5177\u5305\u548c\u5185\u7f6e\u6570\u636e\uff1a<\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(20deg);\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">library(rmda)<\/span><\/code><code><span class=\"code-snippet_outer\">library(ggDCA)<\/span><\/code><code><span class=\"code-snippet_outer\">library(ggplot2)<\/span><\/code><code><span class=\"code-snippet_outer\">library(rms)<\/span><\/code><code><span class=\"code-snippet_outer\">library(caret)<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">data(dcaData)<\/span><\/code><code><span class=\"code-snippet_outer\">head(dcaData)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.42048517520215634\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_PEYmotTjlVhGKL3yl6PwUf4Oyv6Ztg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFx74um4bib5CKXf2IuUkmL2gNIWPEYmotTjlVhGKL3yl6PwUf4Oyv6Ztg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"742\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6a21\u578b\u6784\u5efa<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6784\u5efa\u4e00\u4e2a\u5355\u53d8\u91cf\u7684baseline\u6a21\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">set.seed(<span class=\"code-snippet__number\">123<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">baseline.model <- decision_curve(Cancer ~ Age + Female + Smokes, data = dcaData,<\/span><\/code><code><span class=\"code-snippet_outer\">thresholds = seq(<span class=\"code-snippet__number\">0<\/span>, <span class=\"code-snippet__number\">0.4<\/span>, by = <span class=\"code-snippet__number\">0.005<\/span>), bootstraps = <span class=\"code-snippet__number\">10<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">plot_decision_curve(baseline.model,<\/span><\/code><code><span class=\"code-snippet_outer\">curve.names = <span class=\"code-snippet__string\">\"Baseline Model\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">cost.benefit.axis =<span class=\"code-snippet__literal\">FALSE<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#col= c('red','blue'),<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">confidence.intervals=<span class=\"code-snippet__literal\">FALSE<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">standardize = <span class=\"code-snippet__literal\">FALSE<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.5444444444444444\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_oC4y2NXicianTzFAJdwiaScWHjHuGA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxaJkjh7S3MIfM7MheEW0e8qPqVIUoC4y2NXicianTzFAJdwiaScWHjHuGA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u6ce8\u610f\uff0c\u8fd9\u91cc”all”\u548c”none”\u662f\u4e24\u79cd\u53c2\u8003\u7b56\u7565\uff0c\u7528\u4e8e\u6bd4\u8f83\u9884\u6d4b\u6a21\u578b\u7684\u6548\u76ca\u3002”all”\u53c2\u8003\u7b56\u7565\u610f\u5473\u7740\u5728\u6240\u6709\u60c5\u51b5\u4e0b\u90fd\u8fdb\u884c\u6cbb\u7597\uff0c\u800c”none”\u53c2\u8003\u7b56\u7565\u610f\u5473\u7740\u4e0d\u8fdb\u884c\u6cbb\u7597\u3002\u8fd9\u4e24\u79cd\u53c2\u8003\u7b56\u7565\u7684\u76ee\u7684\u662f\u5e2e\u52a9\u8bc4\u4f30\u9884\u6d4b\u6a21\u578b\u7684\u6548\u76ca\u548c\u4e34\u5e8a\u5b9e\u7528\u6027\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u5728DCA\u7684\u56fe\u50cf\u4e2d\uff0c\u53c2\u8003\u7b56\u7565\u7684\u6548\u76ca\u59cb\u7ec8\u4e3a0\u3002\u9884\u6d4b\u6a21\u578b\u7684\u6548\u76ca\u66f2\u7ebf\u4e0e\u53c2\u8003\u7b56\u7565\u7684\u6548\u76ca\u66f2\u7ebf\u8fdb\u884c\u6bd4\u8f83\uff0c\u4ee5\u786e\u5b9a\u9884\u6d4b\u6a21\u578b\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u4e34\u5e8a\u6548\u76ca\u3002\u5982\u679c\u9884\u6d4b\u6a21\u578b\u7684\u6548\u76ca\u66f2\u7ebf\u5728\u53c2\u8003\u7b56\u7565\u7684\u6548\u76ca\u66f2\u7ebf\u4e4b\u4e0a\uff0c\u5219\u8bf4\u660e\u8be5\u9884\u6d4b\u6a21\u578b\u5728\u8be5\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u5177\u6709\u4e34\u5e8a\u5b9e\u7528\u6027\u3002\u5982\u679c\u9884\u6d4b\u6a21\u578b\u7684\u6548\u76ca\u66f2\u7ebf\u5728\u53c2\u8003\u7b56\u7565\u7684\u6548\u76ca\u66f2\u7ebf\u4e4b\u4e0b\uff0c\u5219\u8bf4\u660e\u8be5\u9884\u6d4b\u6a21\u578b\u5728\u8be5\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u6ca1\u6709\u4e34\u5e8a\u5b9e\u7528\u6027\u3002<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6784\u9020\u4e00\u4e2a\u5168\u53d8\u91cf\u6a21\u578b\uff0c\u53ca\u5c06\u5176\u4ed6\u5269\u4f59\u7684\u53d8\u91cf\u90fd\u52a0\u5165\u6a21\u578b\u4e2d\uff0c\u6784\u5efa\u9884\u6d4b\u6a21\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">set.seed(<span class=\"code-snippet__number\">123<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">full.model <- decision_curve(Cancer~Age + Female + Smokes + Marker1 + Marker2,<\/span><\/code><code><span class=\"code-snippet_outer\">data = dcaData,<\/span><\/code><code><span class=\"code-snippet_outer\">thresholds = seq(<span class=\"code-snippet__number\">0<\/span>, <span class=\"code-snippet__number\">.4<\/span>, by = <span class=\"code-snippet__number\">.005<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\">bootstraps = <span class=\"code-snippet__number\">10<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">plot_decision_curve(full.model,<\/span><\/code><code><span class=\"code-snippet_outer\">curve.names = <span class=\"code-snippet__string\">\"Full Model\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">cost.benefit.axis =<span class=\"code-snippet__literal\">FALSE<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#col= c('red','blue'),<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">confidence.intervals=<span class=\"code-snippet__literal\">FALSE<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">standardize = <span class=\"code-snippet__literal\">FALSE<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5509259259259259\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_yt0VogSH35xHicVTEvPviajSgoLiaQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxu7lf9t8v5SdCzV2Tw73RnAhlU1icyt0VogSH35xHicVTEvPviajSgoLiaQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5bf9\u6bd4\u6a21\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">plot_decision_curve(<span class=\"code-snippet__built_in\">list<\/span>(baseline.model, full.model), curve.names = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"Baseline model\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__string\">\"Full model\"<\/span>), col = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"blue\"<\/span>, <span class=\"code-snippet__string\">\"red\"<\/span>), lty = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__number\">1<\/span>, <span class=\"code-snippet__number\">2<\/span>), lwd = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__number\">3<\/span>, <span class=\"code-snippet__number\">2<\/span>, <span class=\"code-snippet__number\">2<\/span>, <span class=\"code-snippet__number\">1<\/span>), legend.position = <span class=\"code-snippet__string\">\"bottomright\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5416666666666666\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_9c2ujr9T7nwFM1cjxlVtibLy40ygCQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxeKSF0NBeu3xX6us5Je7paBpbC9c2ujr9T7nwFM1cjxlVtibLy40ygCQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u56fe\u4e2d\uff0ccost-benefit\u8f74\u662f\u6307\u6a2a\u8f74\u548c\u7eb5\u8f74\u7684\u6bd4\u4f8b\u5c3a\u3002\u5728\u8fd9\u4e2a\u8f74\u4e0a\uff0c\u6a2a\u8f74\u8868\u793a\u6cbb\u7597\u51b3\u7b56\u7684\u9608\u503c\u6216\u6982\u7387\u9608\u503c\uff0c\u7eb5\u8f74\u8868\u793a\u51b3\u7b56\u6536\u76ca\uff0c\u4e5f\u79f0\u4e3a\u51c0\u83b7\u5229\uff08net benefit\uff09\u6216\u51c0\u6548\u76ca\uff08net benefit\uff09\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">cost-benefit\u8f74\u7684\u6bd4\u4f8b\u5c3a\u662f\u6839\u636e\u4e34\u5e8a\u51b3\u7b56\u7684\u6210\u672c\u548c\u6548\u76ca\u8fdb\u884c\u9009\u62e9\u7684\u3002\u6210\u672c\u53ef\u4ee5\u662f\u6cbb\u7597\u6210\u672c\u3001\u6d4b\u8bd5\u6210\u672c\u3001\u65f6\u95f4\u6210\u672c\u7b49\uff0c\u800c\u6548\u76ca\u53ef\u4ee5\u662f\u6cbb\u6108\u7387\u3001\u751f\u5b58\u7387\u3001\u75bc\u75db\u51cf\u8f7b\u7a0b\u5ea6\u7b49\u3002\u901a\u8fc7\u5c06\u6cbb\u7597\u6210\u672c\u548c\u6548\u76ca\u8003\u8651\u5728\u5185\uff0c\u53ef\u4ee5\u786e\u5b9a\u5728\u4e0d\u540c\u6cbb\u7597\u51b3\u7b56\u9608\u503c\u4e0b\u7684\u6700\u4f18\u7b56\u7565\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u63a5\u4e0b\u6765\u518d\u770b\u770bggDCA\u5de5\u5177\u5305\u5982\u4f55\u7ed8\u5236DCA<\/strong><\/p>\n<\/section>\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;background-color: rgb(255, 255, 255);overflow: hidden;padding-top: 5px;\">\n<section style=\"display: flex;width: 100%;flex-flow: column nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"z-index: 1;\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: center;display: flex;flex-flow: row nowrap;margin-bottom: 5px;\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(340deg) scale(0.65);margin-top: -4px;margin-bottom: -4px;transform-origin: center center;\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 5px;padding-left: 2px;\">\n<section style=\"text-align: justify;letter-spacing: 2px;color: rgb(239, 135, 135);font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5bfc\u5165\u5185\u7f6e\u6570\u636e<\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;\">\n<section style=\"transform: rotateZ(20deg);\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 20px;height: 20px;vertical-align: top;overflow: hidden;border-width: 1px;border-radius: 100%;border-style: solid;border-color: rgb(239, 135, 135);background-color: rgb(242, 203, 206);\">\n<section style=\"margin-top: 2px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 15px;vertical-align: top;overflow: hidden;border-width: 3px;border-radius: 100%;border-style: solid;border-color: rgb(255, 255, 255) rgba(255, 255, 255, 0) rgba(255, 255, 255, 0);background-color: rgb(241, 203, 206);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">data(LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">ddist <- datadist(LIRI) <span class=\"code-snippet__comment\">###\u6253\u5305\u6570\u636e<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">options(datadist = <span class=\"code-snippet__string\">\"ddist\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>ggDCA \u4e2ddca\u53ef\u4ee5\u5b8c\u6210\u5355\u4e2a\u6216\u591a\u4e2a\u6a21\u578b\u7684DCA\u66f2\u7ebf\u7ed8\u5236\uff0c\u6a21\u578b\u5bf9\u8c61\u5305\u62ec\u56db\u4e2a\uff1a<\/strong><\/p>\n<ul class=\"list-paddingleft-1\" style=\"padding-left: 40px;list-style-position: outside;\">\n<li>\n<p>coxph (Cox \u6bd4\u4f8b\u98ce\u9669\u56de\u5f52\u6a21\u578b,Fit Proportional Hazards Regression Model)<\/p>\n<\/li>\n<li>\n<p>cph (Cox \u6bd4\u4f8b\u98ce\u9669\u56de\u5f52\u6a21\u578b,Cox Proportional Hazards Model and Extensions)<\/p>\n<\/li>\n<li>\n<p>glm (\u5e7f\u4e49\u7ebf\u578b\u6a21\u578b,Fitting Generalized Linear Models\uff09<\/p>\n<\/li>\n<li>\n<p>lrm (\u903b\u8f91\u56de\u5f52\u6a21\u578b,Logistic Regression Model)<\/p>\n<\/li>\n<\/ul>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u540c\u65f6\u8fd8\u53ef\u4ee5\u8bbe\u7f6e\u4e0d\u540c\u65f6\u671f\u7684\u9884\u6d4b\u6548\u679c\uff0c\u4e5f\u53ef\u4ee5\u5728\u9a8c\u8bc1\u96c6\u91cc\u9762\u8fdb\u884c\u9a8c\u8bc1\u3002<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6784\u5efaLogistic\u56de\u5f52\u6a21\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6839\u636e\u4e0d\u540c\u60c5\u51b5\uff0c\u6dfb\u52a0\u53d8\u91cf\u5373\u4e3a\u57fa\u56e0\u7684\u4e2a\u6570\uff0c\u6784\u5efa\u56db\u4e2a\u4e0d\u540c\u53d8\u91cf\u7684Logistic \u56de\u5f52\u6a21\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">lrm1 <- lrm(status ~ ANLN, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">lrm2 <- lrm(status ~ ANLN + CENPA, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">lrm3 <- lrm(status ~ ANLN + CENPA + GPR182, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">lrm4 <- lrm(status ~ ANLN + CENPA + GPR182 + BCO2, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u67e5\u770b\u7ed3\u679c\uff0c\u5305\u62ec\u9608\u503c\uff0c\u771f\u9633\u6027\uff0c\u5047\u9633\u6027\uff0c\u51c0\u6536\u76ca<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">dca_lrm <- dca(lrm1, lrm2, lrm3, lrm4, model.names = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"ANLN\"<\/span>, <span class=\"code-snippet__string\">\"ANLN+CENPA\"<\/span>, <span class=\"code-snippet__string\">\"ANLN+CENPA+GPR182\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__string\">\"ANLN+CENPA+GPR182+BCO2\"<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">head(dca_lrm)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.33910891089108913\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_AuGeBPrlscAmjfDj1o1Ov8HoqCAsLQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxoTgPSnzKWCD4bXJUVEVAZrUzAuGeBPrlscAmjfDj1o1Ov8HoqCAsLQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"808\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u7ed8\u5236\uff0c\u5bf9\u6bd4\u4e0d\u540c\u6a21\u578b\u7684DCA\u66f2\u7ebf<br \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">ggplot(dca_lrm, lwd = <span class=\"code-snippet__number\">0.5<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5787037037037037\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_a8RGWJGky996O1fdJKDjgvgbZE6gUg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxLUb4sJP8HibZUKP4Cej57QpXnia8RGWJGky996O1fdJKDjgvgbZE6gUg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u63a5\u4e0b\u6765\u770b\u4e00\u4e0b\u5982\u679c\u662f\u6784\u5efaCOX\u56de\u5f52\u7684\u60c5\u51b5\uff0c\u6b65\u9aa4\u975e\u5e38\u7684\u76f8\u4f3c\uff0c\u4f46\u662f\u6ce8\u610f\u8981\u5bfc\u5165\u4e00\u4e0bsurvival\u5305\uff1a<br \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">library(survival)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6784\u5efaCox\u56de\u5f52\u6a21\u578b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">cph1 <- cph(Surv(time, status) ~ ANLN, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">cph2 <- cph(Surv(time, status) ~ ANLN + CENPA, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">cph3 <- cph(Surv(time, status) ~ ANLN + CENPA + GPR182, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\">cph4 <- cph(Surv(time, status) ~ ANLN + CENPA + GPR182 + BCO2, LIRI)<\/span><\/code><code><span class=\"code-snippet_outer\"><br \/><\/span><\/code><code><span class=\"code-snippet_outer\">dca_cph <- dca(cph1, cph2, cph3, cph4, model.names = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"ANLN\"<\/span>, <span class=\"code-snippet__string\">\"ANLN+CENPA\"<\/span>, <span class=\"code-snippet__string\">\"ANLN+CENPA+GPR182\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__string\">\"ANLN+CENPA+GPR182+BCO2\"<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">head(dca_cph)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-ratio=\"0.30666666666666664\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_ELYsbeFfwZ4AxiaCX3VSt5UbAMmQtg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEU6D3adWhUYK7DAicanbiajFxiad6F1vPzcrxPVvOb7gPrnRPjEELYsbeFfwZ4AxiaCX3VSt5UbAMmQtg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"900\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">ggplot(dca_cph, lwd = <span class=\"code-snippet__number\">0.5<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 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