{"id":57255,"date":"2024-06-16T19:01:18","date_gmt":"2024-06-16T11:01:18","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=57255"},"modified":"2024-06-16T19:01:18","modified_gmt":"2024-06-16T11:01:18","slug":"%e4%b8%80%e6%96%87%e6%90%9e%e5%ae%9a%e7%94%9f%e4%bf%a1%e5%88%86%e6%9e%90%e5%bc%ba%e5%8a%a9%e6%94%bb-%e8%8d%af%e6%95%8f%e5%88%86%e6%9e%90prrophetic%e5%92%8concopredict%e5%8c%85","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=57255","title":{"rendered":"\u4e00\u6587\u641e\u5b9a\u751f\u4fe1\u5206\u6790\u5f3a\u52a9\u653b-\u836f\u654f\u5206\u6790(pRRophetic\u548concoPredict\u5305)"},"content":{"rendered":"


\n
\n<\/title><br \/>\n<meta charset=\"utf-8\"><br \/>\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,maximum-scale=1.0,user-scalable=0,viewport-fit=cover\"><\/p>\n<style>\n*{margin:0;padding:0}html{-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;line-height:1.6}img{z-index:999;position:relative;max-width:100%;margin:10px 0;}body{letter-spacing:.034em}h1,h2,h3,h4,h5,h6{font-weight:400;font-size:16px}a{color:#576b95;text-decoration:none;-webkit-tap-highlight-color:rgba(0,0,0,0)}td,th{word-wrap:break-word;padding:5px 10px;border:1px solid #DDD;}table{margin-bottom:10px;border-collapse:collapse;display:table;width:100%!important;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}.rich_media_area_primary{padding:20px 16px 12px;background-color:#fafafa}@media (max-width:375px){.rich_media_area_primary{padding:20px 60px 15px 60px}.rich_media_area_extra{padding:0 60px 21px 60px}}@media (min-width:1024px){.rich_media_area_primary_inner,.rich_media_area_extra_inner,body{max-width:677px;margin-left:auto;margin-right:auto}.rich_media_area_primary{padding-top:32px}}.rich_media{padding:20px;overflow:hidden;}.appmsg_skin_default .rich_media_area_primary{background-color:#fff}.appmsg_skin_default .rich_media_area_primary .weui-loadmore_line .weui-loadmore__tips{background-color:#fff}@media screen and (min-width:1024px){.rich_media_area_primary_inner,.rich_media_area_extra_inner{max-width:677px;margin-left:auto;margin-right:auto}.rich_media_area_primary{padding-top:32px}}.rich_media_content{overflow:hidden;color:#333;font-size:17px;word-wrap:break-word;-webkit-hyphens:auto;-ms-hyphens:auto;hyphens:auto;text-align:justify;position:relative;z-index:0}.rich_media_content *{max-width:100%!important;box-sizing:border-box!important;-webkit-box-sizing:border-box!important;word-wrap:break-word!important}.rich_media_content p{clear:both;min-height:1em}.rich_media_content em{font-style:italic}.rich_media_content fieldset{min-width:0}.rich_media_content .list-paddingleft-1,.rich_media_content .list-paddingleft-2,.rich_media_content .list-paddingleft-3{padding-left:2.2em}.rich_media_content .list-paddingleft-1 .list-paddingleft-2,.rich_media_content .list-paddingleft-2 .list-paddingleft-2,.rich_media_content .list-paddingleft-3 .list-paddingleft-2{padding-left:30px}.rich_media_content .list-paddingleft-1{padding-left:1.2em}.rich_media_content .list-paddingleft-3{padding-left:3.2em}.rich_media_content .code-snippet,.rich_media_content .code-snippet__fix{max-width:1000%!important}.rich_media_content .code-snippet *,.rich_media_content .code-snippet__fix *{max-width:1000%!important}.rich_media_title{font-size:22px;line-height:1.4;margin-bottom:13px;padding-bottom:13px;border-bottom:1px solid #e7e7eb;}@supports(-webkit-overflow-scrolling:touch){.rich_media_title{font-weight:700}}.rich_media_meta{display:inline-block;vertical-align:middle;padding:0 0 10px 0;font-size:15px;-webkit-tap-highlight-color:rgba(0,0,0,0)}.rich_media_meta.icon_appmsg_tag{margin-right:0px}.rich_media_meta.meta_tag_text{margin-right:0}.rich_media_meta_list em{font-style:normal}.rich_media_meta_text{color:#a5a5a5;}p{margin:0;}.msgBox{margin-top:20px;padding-top:20px;padding-left:50px;overflow:hidden;border-top:2px dashed #09a2ff;}.msg{padding-top:7px;clear:both;}.msgBody{float:right;width:100%;margin-left:55px;padding-bottom:15px;border-bottom:1px dashed #e0e0e0;}.userHeadImg{float:left;margin-left:-50px;}.userHeadImg img{width:40px;height:40px;margin-right:10px;border-radius:3px;}.userName{color:#888888;line-height:24px;font-size:14px;margin:5px 0 5px 0;height:24px;}.replyBody,.autherBody{color:#565656;font-size:15px;}.replyIcon{border-left:4px solid #33ab01;margin-right:5px;}.ad{text-decoration:none;color:#d6d4d4;font-size:12px;}.msgBodyReply{padding-top:5px;}.userName span{float:right;color:#afafaf;font-size:14px;}code{text-align:left;font-size:14px;display:block;white-space:pre;display:-webkit-box;display:-webkit-flex;display:flex;position:relative;}.code-snippet__fix{font-size:14px;margin:10px 0;display:block;color:#333;position:relative;background-color:rgba(0,0,0,0.03);border:1px solid #f0f0f0;border-radius:2px;display:-webkit-box;display:-webkit-flex;display:flex;padding-left:25px;line-height:26px}.code-snippet__fix code{text-align:left;font-size:14px;display:block;white-space:pre;display:-webkit-box;display:-webkit-flex;display:flex;position:relative;font-family:Consolas,\"Liberation Mono\",Menlo,Courier,monospace}.code-snippet__comment,.code-snippet__quote{color:#afafaf;font-style:italic}.code-snippet__keyword,.code-snippet__selector-tag,.code-snippet__subst{color:#ca7d37}.code-snippet__number,.code-snippet__literal,.code-snippet__variable,.code-snippet__template-variable,.code-snippet__tag .code-snippet__attr{color:#0e9ce5}.code-snippet__string,.code-snippet__doctag{color:#d14}.code-snippet__title,.code-snippet__section,.code-snippet__selector-id{color:#d14}.code-snippet__subst{font-weight:normal}.code-snippet__type,.code-snippet__class .code-snippet__title{color:#0e9ce5}.code-snippet__tag,.code-snippet__name,.code-snippet__attribute{color:#0e9ce5;font-weight:normal}.code-snippet__regexp,.code-snippet__link{color:#ca7d37}.code-snippet__symbol,.code-snippet__bullet{color:#d14}.code-snippet__built_in,.code-snippet__builtin-name{color:#ca7d37}.code-snippet__meta{color:#afafaf}.code-snippet__deletion{background:#fdd}.code-snippet__addition{background:#dfd}.code-snippet__emphasis{font-style:italic}.code-snippet__strong{font-weight:bold}.account_avatar{width:40px;height:40px;padding:0;}.account_info{display:-webkit-box;display:-webkit-flex;display:flex;-webkit-box-align:center;-webkit-align-items:center;padding:20px 0;align-items:center}.flex_bd{padding-left:14px;}.account_nickname{display:inline-block;vertical-align:middle;line-height:1.2;color:#576b95;font-size:14px}.account_desc{overflow:hidden;text-overflow:ellipsis;display:-webkit-box;-webkit-box-orient:vertical;-webkit-line-clamp:1;color:rgba(0,0,0,0.3);font-size:14px;line-height:1.2;padding-top:.4em}.msg_source_url{text-align:left;word-break:break-all;margin-top:20px;}.msg_source_url a{padding-right:10px;}.msg_source_url .url_text{color:#a8a8a8;}.video-desc{font-size:14px;margin-top:15px;color:#6c6c6c;}.msg_source_url{text-align:left;}.original_primary_card_tips{color:rgba(0,0,0,0.3);line-height:1.4;font-size:15px;}.weui-flex__item{margin-bottom:20px;padding:20px 16px;margin-top:16px;line-height:1.4;align-items:center;background-color:#f7f7f7;border-radius:8px;position:relative;}.original_primary_desc{color:rgba(0,0,0,0.5);font-size:14px;padding-top:4px;width:auto;overflow:hidden;text-overflow:ellipsis;}.msgBodyReplyList{border-top:1px solid #e1e1e1;margin-top:10px;}.msgBodyReplyListTop{border-top:0;}.reply_like_num{float:right;font-size:14px;color:#c7c7c7;}.msgData{margin-top:20px;color:#626262;}.msgData span{font-size:14px;padding-right:15px;}.msgData .likes{float:right;padding-right:0;}.js_text_content p{font-size:18px;}.rich_media_meta_link{font-size:15px;}blockquote {padding-left: 10px;border-left: 3px solid #dbdbdb;color: rgba(0,0,0,0.5);font-size: 15px;padding-top: 4px;margin: 1em 0;}.video_iframe{width:500px;height:400px;}.blockquote_info{color:#b5b5b5;margin-top:10px;}#copyright_logo{color:#bdbdbd;}.rich_media_meta_list{margin-bottom:10px;}.reprint{background:#efefef;border-radius:5px;padding:8px;color:#1f1f1f;}.reprint a{word-break:break-all;}.topic{color:#8e8e8e;background:#f7f7f7;border-radius:5px;padding:10px 8px;}.topic a{padding-right:5px;}.topic p{margin-bottom:5px;}\n<\/style>\n<link href=\"https:\/\/www.juyifx.cn\/config\/css\/wxArticle.css\" rel=\"stylesheet\"\/>\n<\/head><script>\nvar data={\"mp\":\"\u751f\u4fe1\u679c\",\"title\":\"\u4e00\u6587\u641e\u5b9a\u751f\u4fe1\u5206\u6790\u5f3a\u52a9\u653b-\u836f\u654f\u5206\u6790(pRRophetic\u548concoPredict\u5305)\",\"time\":\"2024-03-28 19:00:40\",\"timeStamp\":\"1711623640\"};\n<\/script><br \/>\n<body><\/p>\n<div class=\"rich_media\">\n<h1 class=\"rich_media_title\" id=\"activity-name\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247501156&idx=1&sn=12b3103e08d73b38a8e75b5c0fde27a6&chksm=cf7f55a1f808dcb7538cfd77b871aebb21dd32dbf48b9fe76e3cfcbc87fa4bf521a0e510b32a#rd\" target=\"_blank\" rel=\"noopener\">\u4e00\u6587\u641e\u5b9a\u751f\u4fe1\u5206\u6790\u5f3a\u52a9\u653b-\u836f\u654f\u5206\u6790(pRRophetic\u548concoPredict\u5305)<\/a><\/h1>\n<div id=\"meta_content\" class=\"rich_media_meta_list\"><span class=\"rich_media_meta rich_media_meta_text\">\u5c0f\u5e08\u59b9  <\/span><span class=\"rich_media_meta rich_media_meta_nickname\" id=\"profileBt\"><a href=\"javascript:void(0);\" class=\"wx_tap_link js_wx_tap_highlight weui-wa-hotarea\" id=\"js_name\">\u751f\u4fe1\u679c  <\/a><\/span><em id=\"publish_time\" class=\"rich_media_meta rich_media_meta_text\">2024-03-28 19:00:40<\/em><\/div>\n<p><content><\/p>\n<div class=\"reprint\">\n<p>\u8f6c\u81ea\u516c\u4f17\u53f7\uff1aR\u8bed\u8a00\u5b66\u5f92<br \/><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg5MDk3Mzg4OA==&mid=2247492138&idx=1&sn=d05faf1ff64bed2da42d6f5d72fd8fb7\" target=\"_blank\" title=\"\u9605\u8bfb\u539f\u6587\" rel=\"noopener\">http:\/\/mp.weixin.qq.com\/s?__biz=Mzg5MDk3Mzg4OA==&mid=2247492138&idx=1&sn=d05faf1ff64bed2da42d6f5d72fd8fb7<\/a><\/p>\n<\/div>\n<p style=\"text-align: center;\" data-mpa-powered-by=\"yiban.io\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100016977\" data-ratio=\"0.2222222222222222\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_r0Gd7iaumIGMiaia97aHFV15nrpdzw-145.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxQW8Zek7Noib2uBhB3ZE3yMxI2Hfic7cGTdPYiacicg47jficdr5BVr0Gd7iaumIGMiaia97aHFV15nrpdzw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"900\" style=\"\" data-recalc-dims=\"1\" \/><\/p>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">\u4e4b\u524d\u679c\u5b50\u5df2\u7ecf\u505a\u8fc7\u4e86\u57fa\u56e0\u8868\u8fbe\u6570\u636e\u4ee5\u53ca\u514d\u75ab\u7ec6\u80de\u6570\u636e\u4e4b\u95f4\u7684\u5173\u7cfb\uff0cR\u5305\u4e4b pRRophetic\u548concoPredict \uff0c\u53ef\u4ee5\u5bf9\u8868\u8fbe\u91cf\u77e9\u9635\u8fdb\u884c\u836f\u7269\u53cd\u5e94\u9884\u6d4b\uff0c\u8fd9\u6b21\u7ed9\u5927\u5bb6\u5e26\u67652021\u5e747\u6708\u7684\u300aoncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data\u300b<\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">\u836f\u7269\u9884\u6d4bR\u5305\u4e4boncoPredict<\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">\u3002\u6211\u4eec\u5148\u6765\u5b66\u4e60\u4e00\u4e0b\u8fd9\u4e24\u4e2aR\u5305\u5427\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"> <\/span><br \/><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">\u672c\u671f\u4e3b\u8981\u7ed9\u5927\u5bb6\u5e26\u6765\u836f\u7269\u654f\u611f\u6027\u5206\u6790\uff0c\u4f7f\u7528 pRRophetic \u4e4b\u524d\u5148\u5b89\u88c5\uff0c\u81ea\u5df1\u4e0b\u8f7dpRRophetic_0.5.tar.gz\u8fd9\u4e2a\u538b\u7f29\u5305\uff08\u5927\u4e8e500M\u54e6\uff09\uff0c\u7136\u540e\u5f53\u524d\u5de5\u4f5c\u76ee\u5f55\u4e0b\u9762\u4f7f\u7528\u4ee3\u7801\u5982\u4e0b\uff1a<\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">          <\/span><o:p><span style=\"font-size: 16px;letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><\/span><\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"shell\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__meta\">#<\/span><span class=\"code-snippet__keyword\">if<\/span> (!requireNamespace(<span class=\"code-snippet__string\">\"BiocManager\"<\/span>, quietly = TRUE))<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__meta\">#<\/span> install.packages(<span class=\"code-snippet__string\">\"BiocManager\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__meta\">#<\/span>BiocManager::install(c(<span class=\"code-snippet__string\">\"limma\"<\/span>, <span class=\"code-snippet__string\">\"car\"<\/span>, <span class=\"code-snippet__string\">\"ridge\"<\/span>, <span class=\"code-snippet__string\">\"preprocessCore\"<\/span>, <span class=\"code-snippet__string\">\"genefilter\"<\/span>, <span class=\"code-snippet__string\">\"sva\"<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__meta\">#<\/span>\u4f7f\u7528 <span class=\"code-snippet__string\">\"BiocManager\"<\/span> \u5305\u6765\u5b89\u88c5\u591a\u4e2a\u5176\u4ed6\u5305\uff0c\u5305\u62ec <span class=\"code-snippet__string\">\"limma\"<\/span>\u3001<span class=\"code-snippet__string\">\"car\"<\/span>\u3001<span class=\"code-snippet__string\">\"ridge\"<\/span>\u3001<span class=\"code-snippet__string\">\"preprocessCore\"<\/span>\u3001<span class=\"code-snippet__string\">\"genefilter\"<\/span> \u548c <span class=\"code-snippet__string\">\"sva\"<\/span>\u3002<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__meta\">#<\/span>install.packages(<span class=\"code-snippet__string\">\"ggplot2\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__meta\">#<\/span>install.packages(<span class=\"code-snippet__string\">\"ggpubr\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"> <\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__meta\">#<\/span>\u5f15\u7528\u5305<\/span><\/code><code><span class=\"code-snippet_outer\">library(limma)<\/span><\/code><code><span class=\"code-snippet_outer\">library(ggpubr)<\/span><\/code><code><span class=\"code-snippet_outer\">library(pRRophetic)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016973\" data-ratio=\"0.17763157894736842\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_mfMOBibicJib8QOyolU7X2tpnomokg.png?resize=304%2C54\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxT3nyMlQ6JWwibtp9AZq7icVbgBD39TNHGuMqNHPN0tiazumCIaQmfMOBibicJib8QOyolU7X2tpnomokg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"304\" height=\"54 .0\" width=\"304 .0\" data-recalc-dims=\"1\" \/><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><\/span><\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"makefile\"><code><span class=\"code-snippet_outer\">library(ggplot2)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u52a0\u8f7d\u6240\u9700\u7684R\u5305\uff0c\u5305\u62ec \"limma\"\u3001\"ggpubr\"\u3001\"pRRophetic\"\u3001\"ggplot2\" \u7b49<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">set.seed(12345)<\/span><\/code><code><span class=\"code-snippet_outer\"> <\/span><\/code><code><span class=\"code-snippet_outer\">pFilter=0.001 <span class=\"code-snippet__comment\">#pvalue\u7684\u8fc7\u6ee4\u6761\u4ef6\u8bbe\u7f6e\u663e\u8457\u6027\u8fc7\u6ee4\u6761\u4ef6\uff0c\u7528\u4e8e\u7b5b\u9009\u5dee\u5f02\u663e\u8457\u7684\u7ed3\u679c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">gene=<span class=\"code-snippet__string\">\"VCAN\"<\/span> <span class=\"code-snippet__comment\">#\u76ee\u6807\u57fa\u56e0<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">expFile=<span class=\"code-snippet__string\">\"symbol.txt\"<\/span> <span class=\"code-snippet__comment\">#\u8868\u8fbe\u6570\u636e\u6587\u4ef6<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> <\/span><\/code><code><span class=\"code-snippet_outer\">setwd(<span class=\"code-snippet__string\">\"\"<\/span>) <span class=\"code-snippet__comment\">#\u8bbe\u7f6e\u5de5\u4f5c\u76ee\u5f55<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> <\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u83b7\u53d6\u836f\u7269\u5217\u8868<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> <\/span><\/code><code><span class=\"code-snippet_outer\">data(cgp2016ExprRma)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8f7d\u5165\u5df2\u7ecf\u63d0\u4f9b\u7684 \"cgp2016ExprRma\" \u6570\u636e\u96c6<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">data(PANCANCER_IC_Tue_Aug_9_15_28_57_2016)<\/span><\/code><code><span class=\"code-snippet_outer\">allDrugs=unique(drugData2016$Drug.name)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8f7d\u5165\u5df2\u7ecf\u63d0\u4f9b\u7684 \"PANCANCER_IC_Tue_Aug_9_15_28_57_2016\" \u6570\u636e\u96c6\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8bfb\u53d6\u8868\u8fbe\u8f93\u5165\u6587\u4ef6,\u5e76\u5bf9\u6570\u636e\u8fdb\u884c\u5904\u7406<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">rt=read.table(expFile, header=T, sep=<span class=\"code-snippet__string\">\"t\"<\/span>, check.names=F)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016976\" data-ratio=\"0.6877076411960132\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_5bkvTibVtwR7PF1JfMMEVSMTky1EXA.png?resize=553%2C380\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxT3nyMlQ6JWwibtp9AZq7icVgibjKqhG4diaUCibGe6jL4BO4jd75bkvTibVtwR7PF1JfMMEVSMTky1EXA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"903\" height=\"380 .6700134277344\" width=\"553 .5399780273438\" data-recalc-dims=\"1\" \/><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><\/span><\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"makefile\"><code><span class=\"code-snippet_outer\">rt=as.matrix(rt)<\/span><\/code><code><span class=\"code-snippet_outer\">rownames(rt)=rt[,1]<\/span><\/code><code><span class=\"code-snippet_outer\">exp=rt[,2:ncol(rt)]<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># \u5c06\u5904\u7406\u540e\u7684\u77e9\u9635\u4e2d\u7684\u8868\u8fbe\u6570\u636e\u63d0\u53d6\u51fa\u6765\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">dimnames=list(rownames(exp),colnames(exp))<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u521b\u5efa\u77e9\u9635 data \u8bbe\u7f6e\u7ef4\u5ea6\u540d\u79f0\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5728R\u4e2d\uff0c\u7ef4\u5ea6\u540d\u79f0\u5141\u8bb8\u4f60\u4e3a\u77e9\u9635\u7684\u884c\u548c\u5217\u6307\u5b9a\u6807\u7b7e\uff0c\u4ee5\u4fbf\u66f4\u597d\u5730\u7406\u89e3\u77e9\u9635\u4e2d\u7684\u6570\u636e<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">data=matrix(as.numeric(as.matrix(exp)),nrow=nrow(exp),dimnames=dimnames)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5c06\u6570\u636e\u77e9\u9635 exp \u8f6c\u6362\u4e3a data \u77e9\u9635\u3002\u5177\u4f53\u6b65\u9aa4\u5982\u4e0b\uff1a<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\"># as.matrix(exp): \u5c06\u6570\u636e\u6846 exp \u8f6c\u6362\u4e3a\u6570\u503c\u578b\u77e9\u9635\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\"># as.numeric(...): \u5c06\u6570\u503c\u578b\u77e9\u9635\u4e2d\u7684\u6570\u636e\u8f6c\u6362\u4e3a\u6570\u503c\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\"># matrix(...): \u4f7f\u7528\u8f6c\u6362\u540e\u7684\u6570\u503c\u548c\u6307\u5b9a\u7684\u884c\u6570\uff08\u7531 nrow(exp) \u7ed9\u51fa\uff09\u548c\u7ef4\u5ea6\u540d\u79f0\uff08\u7531 dimnames \u7ed9\u51fa\uff09\u521b\u5efa\u4e00\u4e2a\u65b0\u7684\u77e9\u9635 data\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5220\u6389\u6b63\u5e38\u6837\u54c1<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">data=avereps(data) <\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u51fd\u6570 avereps \u5bf9\u77e9\u9635 data \u8fdb\u884c\u5904\u7406\u3002avereps \u51fd\u6570\u7684\u76ee\u7684\u662f\u6c42\u6bcf\u4e00\u884c\u7684\u5e73\u5747\u503c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">data=data[rowMeans(data)>0.5,]<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5c06\u77e9\u9635 data \u8fdb\u4e00\u6b65\u5904\u7406\uff0c\u53ea\u4fdd\u7559\u884c\u5e73\u5747\u503c\u5927\u4e8e0.5\u7684\u884c\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6392\u9664\u90a3\u4e9b\u5e73\u5747\u8868\u8fbe\u91cf\u8f83\u4f4e\u7684\u6837\u672c\uff0c\u4ee5\u4fbf\u66f4\u5173\u6ce8\u8868\u8fbe\u4e30\u5ea6\u8f83\u9ad8\u7684\u6837\u672c\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">group=sapply(strsplit(colnames(data),<span class=\"code-snippet__string\">\"\\-\"<\/span>), <span class=\"code-snippet__string\">\"[\"<\/span>, 4)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5c06\u77e9\u9635 data \u7684\u5217\u540d\u8fdb\u884c\u5904\u7406\uff0c\u63d0\u53d6\u51fa\u6bcf\u5217\u540d\u79f0\u7684\u7b2c\u56db\u4e2a\u90e8\u5206\uff08\u4f7f\u7528 \"-\" \u4f5c\u4e3a\u5206\u9694\u7b26\uff09\u3002\u7528\u4e8e\u4ece\u6837\u672c\u540d\u4e2d\u83b7\u53d6\u6837\u672c\u7684\u5206\u7ec4\u4fe1\u606f\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">group=sapply(strsplit(group,<span class=\"code-snippet__string\">\"\"<\/span>), <span class=\"code-snippet__string\">\"[\"<\/span>, 1)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5c06\u6bcf\u4e2a\u5b57\u7b26\u4e32\u4e2d\u7684\u6bcf\u4e2a\u5b57\u7b26\u4f5c\u4e3a\u5355\u72ec\u7684\u5143\u7d20\u3002\u7136\u540e\uff0c\u4f7f\u7528 [ \u51fd\u6570\u63d0\u53d6\u6bcf\u4e2a\u5b57\u7b26\u4e32\u7684\u7b2c\u4e00\u4e2a\u5b57\u7b26\u3002\u8fd9\u53ef\u80fd\u662f\u4e3a\u4e86\u8fdb\u4e00\u6b65\u5904\u7406\u6837\u672c\u5206\u7ec4\u4fe1\u606f\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">group=gsub(<span class=\"code-snippet__string\">\"2\"<\/span>,<span class=\"code-snippet__string\">\"1\"<\/span>,group)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u7528 gsub \u51fd\u6570\u5c06\u6240\u6709\u5b57\u7b26\u4e32\u4e2d\u7684\u5b57\u7b26 \"2\" \u66ff\u6362\u4e3a \"1\"\u3002\u8fd9\u53ef\u80fd\u662f\u5c06\u6837\u672c\u5206\u7ec4\u4fe1\u606f\u8fdb\u884c\u6807\u51c6\u5316\u6216\u91cd\u65b0\u7f16\u7801\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">data=data[,group==0]<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5c06\u77e9\u9635 data \u8fdb\u4e00\u6b65\u5904\u7406\uff0c\u53ea\u4fdd\u7559\u6837\u672c\u5206\u7ec4\u4fe1\u606f\u4e3a \"0\" \u7684\u5217\u3002\u8fd9\u53ef\u80fd\u662f\u4e3a\u4e86\u53ea\u4fdd\u7559\u7279\u5b9a\u6837\u672c\u5206\u7ec4\u7684\u6570\u636e\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">data=t(data)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5bf9\u77e9\u9635 data \u8fdb\u884c\u8f6c\u7f6e\uff0c\u5c06\u884c\u5217\u4e92\u6362<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">rownames(data)=gsub(<span class=\"code-snippet__string\">\"(.*?)\\-(.*?)\\-(.*?)\\-.*\"<\/span>, <span class=\"code-snippet__string\">\"\\1\\-\\2\\-\\3\"<\/span>, rownames(data))<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u7528\u6b63\u5219\u8868\u8fbe\u5f0f\u5904\u7406\u77e9\u9635 data \u7684\u884c\u540d\uff0c\u4ece\u4e2d\u63d0\u53d6\u51fa\u6240\u9700\u7684\u4fe1\u606f\uff0c\u5e76\u91cd\u65b0\u8bbe\u7f6e\u884c\u540d\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">data=t(avereps(data))<\/span><\/code><code><span class=\"code-snippet_outer\"> <\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6839\u636e\u76ee\u6807\u57fa\u56e0\u7684\u8868\u8fbe\u91cf\u5bf9\u6837\u54c1\u8fdb\u884c\u5206\u7ec4<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">geneExp=as.data.frame(t(data[gene,,drop=F]))<\/span><\/code><code><span class=\"code-snippet_outer\">geneExp$Type=ifelse(geneExp[,gene]>median(geneExp[,gene]), <span class=\"code-snippet__string\">\"High\"<\/span>, <span class=\"code-snippet__string\">\"Low\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u4ece\u77e9\u9635 data \u4e2d\u9009\u62e9\u4e0e\u76ee\u6807\u57fa\u56e0\u76f8\u5173\u7684\u884c\uff0c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5e76\u4f7f\u7528\u9017\u53f7 , \u6765\u6307\u5b9a\u5217\u7684\u9009\u62e9\u3002drop=F \u53c2\u6570\u786e\u4fdd\u5373\u4f7f\u53ea\u9009\u62e9\u4e00\u5217\uff0c\u7ed3\u679c\u4e5f\u4f1a\u4fdd\u6301\u4e3a\u77e9\u9635\u800c\u4e0d\u662f\u5411\u91cf\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">for(drug in allDrugs){<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u9884\u6d4b\u836f\u7269\u654f\u611f\u6027<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> possibleError=tryCatch(<\/span><\/code><code><span class=\"code-snippet_outer\"> {senstivity=pRRopheticPredict(data, drug, selection=1, dataset = <span class=\"code-snippet__string\">\"cgp2016\"<\/span>)},<\/span><\/code><code><span class=\"code-snippet_outer\"> error=function(e) e)<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u4f7f\u7528 tryCatch \u51fd\u6570\uff0c\u5c1d\u8bd5\u6267\u884c\u836f\u7269\u654f\u611f\u6027\u9884\u6d4b\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u5982\u679c\u5728\u6267\u884c\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u9519\u8bef\uff0c\u5c06\u5728\u9519\u8bef\u5904\u7406\u51fd\u6570\u4e2d\u6355\u83b7\u9519\u8bef\u5e76\u5b58\u50a8\u5728 possibleError \u4e2d\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> if(inherits(possibleError, <span class=\"code-snippet__string\">\"error\"<\/span>)){next}<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u5982\u679c possibleError \u5305\u542b\u4e86\u4e00\u4e2a\u9519\u8bef\uff0c\u90a3\u4e48\u8fd9\u884c\u4ee3\u7801\u5c06\u8df3\u8fc7\u5f53\u524d\u836f\u7269\uff0c\u7ee7\u7eed\u4e0b\u4e00\u4e2a\u5faa\u73af\u8fed\u4ee3\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> senstivity=senstivity[senstivity!=<span class=\"code-snippet__string\">\"NaN\"<\/span>]<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u79fb\u9664\u836f\u7269\u654f\u611f\u6027\u7ed3\u679c\u4e2d\u7684 \"NaN\" \u503c\uff0c\u5c06\u6709\u6548\u7684\u836f\u7269\u654f\u611f\u6027\u503c\u5b58\u50a8\u5728\u53d8\u91cf senstivity \u4e2d\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> senstivity[senstivity>quantile(senstivity,0.99)]=quantile(senstivity,0.99)<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u5bf9\u836f\u7269\u654f\u611f\u6027\u503c\u8fdb\u884c\u5904\u7406\uff0c\u5c06\u9ad8\u4e8e 0.99 \u5206\u4f4d\u6570\u7684\u503c\u8bbe\u7f6e\u4e3a 0.99\u3002\u8fd9\u53ef\u80fd\u662f\u4e3a\u4e86\u53bb\u9664\u6781\u7aef\u5f02\u5e38\u503c\uff0c\u4ee5\u83b7\u5f97\u66f4\u597d\u7684\u53ef\u89c6\u5316\u6548\u679c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u5c06\u8868\u8fbe\u6570\u636e\u4e0e\u836f\u7269\u654f\u611f\u6027\u7684\u7ed3\u679c\u8fdb\u884c\u5408\u5e76<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> sameSample=intersect(row.names(geneExp), names(senstivity))<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u627e\u5230 geneExp \u4e2d\u4e0e\u836f\u7269\u654f\u611f\u6027\u7ed3\u679c\u5177\u6709\u76f8\u540c\u6837\u672c\u540d\u79f0\u7684\u6837\u672c\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> geneExp=geneExp[sameSample, <span class=\"code-snippet__string\">\"Type\"<\/span>,drop=F]<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u4ece geneExp \u4e2d\u9009\u62e9\u4e0e\u836f\u7269\u654f\u611f\u6027\u7ed3\u679c\u76f8\u540c\u7684\u6837\u672c\uff0c\u4ec5\u4fdd\u7559 \"Type\" \u5217\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> senstivity=senstivity[sameSample]<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u4ece\u836f\u7269\u654f\u611f\u6027\u7ed3\u679c\u4e2d\u9009\u62e9\u4e0e geneExp \u76f8\u540c\u6837\u672c\u7684\u654f\u611f\u6027\u503c\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> rt=cbind(geneExp, senstivity)<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u5c06\u57fa\u56e0\u8868\u8fbe\u5206\u7ec4\u548c\u836f\u7269\u654f\u611f\u6027\u7ed3\u679c\u5408\u5e76\u5230\u4e00\u4e2a\u6570\u636e\u6846\u4e2d\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u8bbe\u7f6e\u6bd4\u8f83\u7ec4<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> rt$Type=factor(rt$Type, levels=c(<span class=\"code-snippet__string\">\"Low\"<\/span>, <span class=\"code-snippet__string\">\"High\"<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u5c06 \"Type\" \u5217\u8f6c\u6362\u4e3a\u56e0\u5b50\uff0c\u8bbe\u5b9a\u6c34\u5e73\u4e3a \"Low\" \u548c \"High\"\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> type=levels(factor(rt[,<span class=\"code-snippet__string\">\"Type\"<\/span>]))<\/span><\/code><code><span class=\"code-snippet_outer\"> comp=combn(type, 2)<\/span><\/code><code><span class=\"code-snippet_outer\"> my_comparisons=list()<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u521b\u5efa\u4e00\u4e2a\u7a7a\u5217\u8868\u6765\u5b58\u50a8\u5206\u7ec4\u6bd4\u8f83<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> for(i in 1:ncol(comp)){my_comparisons[[i]]<-comp[,i]}<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u5c06\u6240\u6709\u53ef\u80fd\u7684\u5206\u7ec4\u6bd4\u8f83\u6dfb\u52a0\u5230 my_comparisons \u5217\u8868\u4e2d\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u83b7\u53d6\u9ad8\u4f4e\u8868\u8fbe\u7ec4\u5dee\u5f02\u7684pvalue<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> test=wilcox.test(senstivity~Type, data=rt)<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u6267\u884c Wilcoxon \u79e9\u548c\u68c0\u9a8c\uff0c\u68c0\u9a8c\u836f\u7269\u654f\u611f\u6027\u662f\u5426\u5728\u4e0d\u540c\u57fa\u56e0\u8868\u8fbe\u5206\u7ec4\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> diffPvalue=test$p.value<\/span><\/code><code><span class=\"code-snippet_outer\"> if(diffPvalue <pFilter){< span><\/span><\/code><code><span class=\"code-snippet_outer\"> <\/pFilter){<><\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u7ed8\u5236\u7bb1\u7ebf\u56fe<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> boxplot=ggboxplot(rt, x=<span class=\"code-snippet__string\">\"Type\"<\/span>, y=<span class=\"code-snippet__string\">\"senstivity\"<\/span>, fill=<span class=\"code-snippet__string\">\"Type\"<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"> xlab=gene,<\/span><\/code><code><span class=\"code-snippet_outer\"> ylab=paste0(drug, <span class=\"code-snippet__string\">\" senstivity (IC50)\"<\/span>),<\/span><\/code><code><span class=\"code-snippet_outer\"> legend.title=gene,<\/span><\/code><code><span class=\"code-snippet_outer\"> palette=c(<span class=\"code-snippet__string\">\"#0066FF\"<\/span>,<span class=\"code-snippet__string\">\"#FF0000\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"> )+ <\/span><\/code><code><span class=\"code-snippet_outer\"> stat_compare_means(comparisons=my_comparisons)<\/span><\/code><code><span class=\"code-snippet_outer\"> pdf(file=paste0(<span class=\"code-snippet__string\">\"durgSenstivity.\"<\/span>, drug, <span class=\"code-snippet__string\">\".pdf\"<\/span>), width=5, height=4.5)<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__comment\">#\u521b\u5efa\u4e00\u4e2a PDF \u6587\u4ef6\uff0c\u7528\u4e8e\u4fdd\u5b58\u7ed8\u5236\u7684\u7bb1\u7ebf\u56fe\uff0c\u6587\u4ef6\u540d\u6839\u636e\u5f53\u524d\u836f\u7269\u547d\u540d\u3002<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> print(boxplot)<\/span><\/code><code><span class=\"code-snippet_outer\"> dev.off()<\/span><\/code><code><span class=\"code-snippet_outer\"> }<\/span><\/code><code><span class=\"code-snippet_outer\">}<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">          <\/span><o:p><span style=\"font-size: 16px;letter-spacing: 1px;\"> <\/span><\/o:p><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016974\" data-ratio=\"1.7228915662650603\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_uWaz1MWHeibc1czHMibAOpOw7hnwvA.png?resize=293%2C506\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxT3nyMlQ6JWwibtp9AZq7icVAgSlYwUK05IbibXmsonQ3YrJ0LOuWaz1MWHeibc1czHMibAOpOw7hnwvA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"332\" height=\"506 .21002197265625\" width=\"293 .79998779296875\" data-recalc-dims=\"1\" \/><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016975\" data-ratio=\"0.9709677419354839\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_bNbz3QaIL3K1PamZB4oH9bEgAEzuPA.png?resize=270%2C262\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxT3nyMlQ6JWwibtp9AZq7icVB4K8pAu863zefh1WicCLyH34EbNbz3QaIL3K1PamZB4oH9bEgAEzuPA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"620\" height=\"262 .8699951171875\" width=\"270 .6000061035156\" data-recalc-dims=\"1\" \/><img decoding=\"async\" loading=\"lazy\" data-imgfileid=\"100016979\" data-ratio=\"0.9109697933227345\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_YKgNX6UfAqViaeW4gsUiaztAKgbBpg.png?resize=274%2C250\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxT3nyMlQ6JWwibtp9AZq7icVDCWEicNYdLvnqYh29zR3iaIOEiaBPYKgNX6UfAqViaeW4gsUiaztAKgbBpg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"629\" height=\"250 .20001220703125\" width=\"274 .47003173828125\" data-recalc-dims=\"1\" \/><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016980\" data-ratio=\"0.888135593220339\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_TczPJjmaOFkZOOPicQxGkTJSXlRqTA.png?resize=257%2C228\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxT3nyMlQ6JWwibtp9AZq7icVC9mtVV60P0GncLYghTN4TcWibbTczPJjmaOFkZOOPicQxGkTJSXlRqTA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"590\" height=\"228 .739990234375\" width=\"257 .4700012207031\" data-recalc-dims=\"1\" \/><img decoding=\"async\" loading=\"lazy\" data-imgfileid=\"100016978\" data-ratio=\"0.8882882882882883\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_wDqkV9rkdNja14sq5s2WLk09vmN0NQ.png?resize=242%2C214\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxT3nyMlQ6JWwibtp9AZq7icVFsnRBXn54aruAaaQRZKzRcUewDqkV9rkdNja14sq5s2WLk09vmN0NQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"555\" height=\"214 .94000244140625\" width=\"242 .1400146484375\" data-recalc-dims=\"1\" \/><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">          <\/span><o:p><span style=\"font-size: 16px;letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">          <\/span><o:p><span style=\"font-size: 16px;letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">\u8fd8\u6709\u4e00\u4e2aR\u5305oncoPredict\uff0c\u836f\u7269\u9884\u6d4b\u9700\u8981\u8bad\u7ec3\u96c6\uff0c\u4e00\u822c\u6765\u8bf4\u63a8\u8350\u4f7f\u7528\u6743\u5a01\u8d44\u6e90\u4f5c\u4e3a\u8bad\u7ec3\u96c6\u5efa\u597d\u6a21\u578b\uff0c\u8fd9\u6837\u5c31\u53ef\u4ee5\u53bb\u9884\u6d4b\u4f60\u81ea\u5df1\u7684\u6570\u636e\u3002Cancer Therapeutics Response Portal (CTRP) \u548c Genomics of Drug Sensitivity in Cancer (GDSC) \uff0c\u516b\u767e\u591a\u4e2a\u7ec6\u80de\u7cfb\u7684\u7ea62\u4e07\u4e2a\u57fa\u56e0\u7684\u8868\u8fbe\u91cf\u77e9\u9635\uff0c\u4ee5\u53ca\u5bf9\u5e94\u516b\u767e\u591a\u7ec6\u80de\u7cfb\u7684\u7ea6200\u4e2a\u836f\u7269\u7684IC50\u503c\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><\/span><\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"makefile\"><code><span class=\"code-snippet_outer\">library(reshape2)<\/span><\/code><code><span class=\"code-snippet_outer\">library(ggpubr)<\/span><\/code><code><span class=\"code-snippet_outer\">th=theme(axis.text.x = element_text(angle = 45,vjust = 0.5))<\/span><\/code><code><span class=\"code-snippet_outer\">dir='.\/DataFiles\/Training Data\/'<\/span><\/code><code><span class=\"code-snippet_outer\">GDSC2_Expr = readRDS(file=file.path(dir,'GDSC2_Expr (RMA Normalized and Log Transformed).rds'))<\/span><\/code><code><span class=\"code-snippet_outer\">dim(GDSC2_Expr) <\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__section\">GDSC2_Expr[1:4, 1:4]<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__section\">boxplot(GDSC2_Expr[,1:4])<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">df=melt(GDSC2_Expr[,1:4])<\/span><\/code><code><span class=\"code-snippet_outer\">head(df)<\/span><\/code><code><span class=\"code-snippet_outer\">p1=ggboxplot(df, <span class=\"code-snippet__string\">\"Var2\"<\/span>, <span class=\"code-snippet__string\">\"value\"<\/span>) +th<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\"># Read GDSC2 response data. rownames() are samples, colnames() are drugs. <\/span><\/span><\/code><code><span class=\"code-snippet_outer\">dir<\/span><\/code><code><span class=\"code-snippet_outer\">GDSC2_Res = readRDS(file = file.path(dir,<span class=\"code-snippet__string\">\"GDSC2_Res.rds\"<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">dim(GDSC2_Res) <span class=\"code-snippet__comment\"># 805 198<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__section\">GDSC2_Res[1:4, 1:4]<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">p2=ggboxplot(melt(GDSC2_Res[ , 1:4]), <span class=\"code-snippet__string\">\"Var2\"<\/span>, <span class=\"code-snippet__string\">\"value\"<\/span>) +th ; p2<span class=\"code-snippet__comment\"># IMPORTANT <span class=\"code-snippet__doctag\">note:<\/span> here I do e^IC50 since the IC50s are actual ln values\/log transformed already, and the calcPhenotype function Paul #has will do a power transformation (I assumed it would be better to not have both transformations) <\/span><\/span><\/code><code><span class=\"code-snippet_outer\">GDSC2_Res <- exp(GDSC2_Res) <\/span><\/code><code><span class=\"code-snippet_outer\">p3=ggboxplot(melt(GDSC2_Res[ , 1:4]), <span class=\"code-snippet__string\">\"Var2\"<\/span>, <span class=\"code-snippet__string\">\"value\"<\/span>) +th ; p3<\/span><\/code><code><span class=\"code-snippet_outer\"> <\/span><\/code><code><span class=\"code-snippet_outer\">library(patchwork)<\/span><\/code><code><span class=\"code-snippet_outer\">p1+p2+p3<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016981\" data-ratio=\"0.6023017902813299\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_XsYkicXlcvFKRzFL35xfJtYfU4DQsg.png?resize=553%2C333\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxT3nyMlQ6JWwibtp9AZq7icVDuA21yRkp1fnFzeEliaUrlave5XsYkicXlcvFKRzFL35xfJtYfU4DQsg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"782\" height=\"333 .469970703125\" width=\"553 .6799926757812\" data-recalc-dims=\"1\" \/><\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"javascript\"><code><span class=\"code-snippet_outer\">ggboxplot(melt(GDSC2_Res[ <span class=\"code-snippet__number\">1<\/span>:<span class=\"code-snippet__number\">4<\/span> ,]), <span class=\"code-snippet__string\">\"Var1\"<\/span>, <span class=\"code-snippet__string\">\"value\"<\/span>) +th<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">          <\/span><o:p><span style=\"font-size: 16px;letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016982\" data-ratio=\"0.6197530864197531\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_xHtU4ZZXGicVhscnCLD2CdJyic2oEw.png?resize=553%2C342\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxT3nyMlQ6JWwibtp9AZq7icVehaI9nTMwia0icPMLBicmUqtnZiaSqxHtU4ZZXGicVhscnCLD2CdJyic2oEw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"810\" height=\"342 .8699951171875\" width=\"553 .2100219726562\" data-recalc-dims=\"1\" \/><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">          <\/span><o:p><span style=\"font-size: 16px;letter-spacing: 1px;\"> <\/span><\/o:p><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">\u56e0\u4e3a\u6bcf\u4e2a\u7ec6\u80de\u7cfb\u7684\u7bb1\u7ebf\u56fe\u91cc\u9762\u90fd\u662f\u7ea6200\u4e2a\u836f\u7269\uff0c\u6240\u4ee5\u8fd9\u6837\u7684\u53ef\u89c6\u5316\u770b\u4e0d\u51fa\u6765\u5177\u4f53 \u7684\u836f\u7269\u8868\u73b0\uff0c\u5e76\u6ca1\u6709\u592a\u5927\u7684\u610f\u4e49\u3002\u6211\u4eec\u5e94\u8be5\u662f\u76f4\u63a5\u770btop\u836f\u7269\u5373\u53ef\uff1a<\/span><\/section>\n<pre style=\"text-align: justify;\"><section style=\"margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><\/span><\/section><\/pre>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"javascript\"><code><span class=\"code-snippet_outer\">round(apply(GDSC2_Res[ <span class=\"code-snippet__number\">1<\/span>:<span class=\"code-snippet__number\">4<\/span> ,], <span class=\"code-snippet__number\">1<\/span>, <span class=\"code-snippet__function\"><span class=\"code-snippet__keyword\">function<\/span>(<span class=\"code-snippet__params\">x<\/span>)<\/span>{<\/span><\/code><code><span class=\"code-snippet_outer\"> <span class=\"code-snippet__keyword\">return<\/span>(c(<\/span><\/code><code><span class=\"code-snippet_outer\"> head(sort(x)),<\/span><\/code><code><span class=\"code-snippet_outer\"> tail(sort(x))<\/span><\/code><code><span class=\"code-snippet_outer\"> ))<\/span><\/code><code><span class=\"code-snippet_outer\">}),<span class=\"code-snippet__number\">2<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<pre style=\"text-align: justify;\"><section style=\"margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><\/span><\/section><\/pre>\n<pre style=\"text-align: justify;\"> <\/pre>\n<pre style=\"text-align: justify;\"><section style=\"margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016983\" data-ratio=\"0.5762962962962963\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_h2ZKFMr4nhn1kdquLQob7qhyWY0Emw.png?resize=553%2C319\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxT3nyMlQ6JWwibtp9AZq7icV3U4EXMQYnygGXYGtMb9rNtPAh2ZKFMr4nhn1kdquLQob7qhyWY0Emw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"675\" height=\"319 .0\" width=\"553 .5399780273438\" data-recalc-dims=\"1\" \/><\/section><\/pre>\n<pre style=\"text-align: justify;\"><section><br \/><\/section><\/pre>\n<pre style=\"text-align: justify;\"><section style=\"text-align: justify;\"><span style=\"font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;font-size: var(--articleFontsize);letter-spacing: 0.034em;\">\u6bcf\u4e2a\u7ec6\u80de\u7cfb\u90fd\u662f\u6709\u81ea\u5df1\u7684\u7279\u5f02\u6027\u836f\u7269\u548c\u5e9f\u7269\u836f\u7269\uff0cIC50\u63a5\u8fd1\u4e8e0\u7684\u5c31\u662f\u795e\u836f<\/span><\/section><section style=\"text-align: justify;\"><span style=\"font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;font-size: var(--articleFontsize);letter-spacing: 0.034em;\">\u3002<\/span><span style=\"font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;font-size: var(--articleFontsize);letter-spacing: 0.034em;\">\u8868\u8fbe\u91cf\u77e9\u9635\u662f\u4eceGenomics of Drug Sensitivity in Cancer (GDSC) \u7684<\/span><\/section><\/pre>\n<pre><section><span style=\"font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;font-size: var(--articleFontsize);letter-spacing: 0.034em;\">v2\u91cc\u9762\u968f\u673a\u6311\u900910\u4e2a\u7ec6\u80de\u7cfb\u4f5c\u4e3a\u8981\u9884\u6d4b\u7684\u77e9\u9635\u3002\u8bfb\u5165\u8bad\u7ec3\u96c6\u7684\u8868\u8fbe\u91cf\u77e9\u9635<\/span><\/section><section><span style=\"font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;font-size: var(--articleFontsize);letter-spacing: 0.034em;\">\u548c\u836f\u7269\u5904\u7406\u4fe1\u606f\u3002<\/span><\/section><\/pre>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><\/span><\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"sql\"><code><span class=\"code-snippet_outer\">install.packages(<span class=\"code-snippet__string\">\"oncoPredict\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">rm(<span class=\"code-snippet__keyword\">list<\/span> = ls()) <span class=\"code-snippet__comment\">## \u9b54\u5e7b\u64cd\u4f5c\uff0c\u4e00\u952e\u6e05\u7a7a~<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">options(stringsAsFactors = F)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__keyword\">library<\/span>(oncoPredict)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__keyword\">library<\/span>(data.table)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__keyword\">library<\/span>(gtools) <\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__keyword\">library<\/span>(reshape2)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__keyword\">library<\/span>(ggpubr)<\/span><\/code><code><span class=\"code-snippet_outer\">th=theme(axis.text.x = element_text(angle = <span class=\"code-snippet__number\">45<\/span>,vjust = <span class=\"code-snippet__number\">0.5<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">dir=<span class=\"code-snippet__string\">'.\/DataFiles\/Training Data\/'<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">GDSC2_Expr = readRDS(<span class=\"code-snippet__keyword\">file<\/span>=file.path(dir,<span class=\"code-snippet__string\">'GDSC2_Expr (RMA Normalized and Log Transformed).rds'<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">GDSC2_Res = readRDS(<span class=\"code-snippet__keyword\">file<\/span> = file.path(dir,<span class=\"code-snippet__string\">\"GDSC2_Res.rds\"<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">GDSC2_Res <- <span class=\"code-snippet__keyword\">exp<\/span>(GDSC2_Res) <\/span><\/code><code><span class=\"code-snippet_outer\">testExpr<- GDSC2_Expr[,<span class=\"code-snippet__keyword\">sample<\/span>(<span class=\"code-snippet__number\">1<\/span>:ncol(GDSC2_Expr),<span class=\"code-snippet__number\">10<\/span>)]testExpr[<span class=\"code-snippet__number\">1<\/span>:<span class=\"code-snippet__number\">4<\/span>,<span class=\"code-snippet__number\">1<\/span>:<span class=\"code-snippet__number\">4<\/span>] <\/span><\/code><code><span class=\"code-snippet_outer\">colnames(testExpr)=paste0(<span class=\"code-snippet__string\">'test'<\/span>,colnames(testExpr))<\/span><\/code><code><span class=\"code-snippet_outer\">dim(testExpr) <\/span><\/code><code><span class=\"code-snippet_outer\">calcPhenotype(trainingExprData = GDSC2_Expr,<\/span><\/code><code><span class=\"code-snippet_outer\"> trainingPtype = GDSC2_Res,<\/span><\/code><code><span class=\"code-snippet_outer\"> testExprData = testExpr,<\/span><\/code><code><span class=\"code-snippet_outer\"> batchCorrect = <span class=\"code-snippet__string\">'eb'<\/span>, <span class=\"code-snippet__comment\"># \"eb\" for ComBat <\/span><\/span><\/code><code><span class=\"code-snippet_outer\"> powerTransformPhenotype = <span class=\"code-snippet__literal\">TRUE<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"> removeLowVaryingGenes = <span class=\"code-snippet__number\">0.2<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\"> minNumSamples = <span class=\"code-snippet__number\">10<\/span>, <\/span><\/code><code><span class=\"code-snippet_outer\"> printOutput = <span class=\"code-snippet__literal\">TRUE<\/span>, <\/span><\/code><code><span class=\"code-snippet_outer\"> removeLowVaringGenesFrom = <span class=\"code-snippet__string\">'rawData'<\/span> )<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u89e3\u8bfb\u836f\u7269\u9884\u6d4b\u7ed3\u679c<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__keyword\">library<\/span>(data.table)testPtype <- fread(<span class=\"code-snippet__string\">'.\/calcPhenotype_Output\/DrugPredictions.csv'<\/span>, data.table = F)testPtype[<span class=\"code-snippet__number\">1<\/span>:<span class=\"code-snippet__number\">4<\/span>, <span class=\"code-snippet__number\">1<\/span>:<span class=\"code-snippet__number\">4<\/span>]<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">          <\/span><o:p><span style=\"font-size: 16px;letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">\u836f\u7269\u654f\u611f\u6027\u5206\u6790\u53ef\u4ee5\u5e2e\u52a9\u7814\u6df1\u5165\u4e86\u89e3\u836f\u7269\u7684\u4f5c\u7528\u673a\u5236\u3002\u901a\u8fc7\u5206\u6790\u4e0d\u540c\u57fa\u56e0\u8868\u8fbe\u5206\u7ec4\u7684\u836f\u7269\u654f\u611f\u6027\u5dee\u5f02\uff0c\u53ef\u4ee5\u63ed\u793a\u836f\u7269\u4e0e\u7279\u5b9a\u751f\u7269\u5b66\u8fc7\u7a0b\u548c\u9014\u5f84\u4e4b\u95f4\u7684\u5173\u8054\uff0c\u4ece\u800c\u5e2e\u52a9\u89e3\u91ca\u836f\u7269\u7684\u6cbb\u7597\u6548\u679c\u3002\u4e0b\u671f\u5c06\u4e3a\u4f60\u5e26\u6765\u66f4\u591aR\u8bed\u8a00\u7684\u9a9a\u64cd\u4f5c\u6280\u5de7\uff0c\u4ee5\u4e0b\u63a8\u8350\u7684\u662f\u4e00\u4e2a\u591a\u529f\u80fd\u7684\u751f\u4fe1\u5e73\u53f0\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">\u4e91\u751f\u4fe1\u5e73\u53f0\u94fe\u63a5\uff1a<\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">http:\/\/www.biocloudservice.com\/home.html\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">\u4e91\u751f\u4fe1\u5e73\u53f0\u94fe\u63a5\uff1a<\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">http:\/\/www.biocloudservice.com\/home.html\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">\u4e91\u751f\u4fe1\u5e73\u53f0\u94fe\u63a5\uff1a<\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">http:\/\/www.biocloudservice.com\/home.html\u3002<\/span><\/section>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100017457\" data-ratio=\"1.6033333333333333\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_NZDs1P5EuYO90qkJv458YF5j5WO8sQ.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxehKmTVMQJQZYpMAYwyg02mT6sRK9vCcB5RwzRibdM1UP62NZDs1P5EuYO90qkJv458YF5j5WO8sQ\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"900\" style=\"\" data-recalc-dims=\"1\"><\/p>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\"><span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\"><\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016984\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_B2jkicacLzPjw4xMSqVvoucZjonVDA-7.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100016986\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/14_7TvAyUibd1TPhJmZfialJtv6tu2SEg-8.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100016985\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/15_9N02aBaau07RufXeXRLmvAHsrFZxtw-6.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;text-wrap: wrap;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"text-align: justify;margin-top: 8px;margin-bottom: 8px;line-height: 1.6em;\"><o:page><\/o:page><\/section>\n<p style=\"display: none;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00\u6587\u641e\u5b9a\u751f\u4fe1\u5206\u6790\u5f3a\u52a9\u653b-\u836f\u654f\u5206\u6790(pRRophetic\u548concoPredict\u5305) \u5c0f\u5e08\u59b9 &nbs […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/57255"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=57255"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/57255\/revisions"}],"predecessor-version":[{"id":57271,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/57255\/revisions\/57271"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=57255"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=57255"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=57255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}