{"id":57318,"date":"2024-06-16T19:10:03","date_gmt":"2024-06-16T11:10:03","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=57318"},"modified":"2024-06-16T19:10:03","modified_gmt":"2024-06-16T11:10:03","slug":"%e8%bf%98%e6%9c%89%e9%ab%98%e6%89%8b%ef%bc%9f%e6%9c%80%e6%96%b0%e5%8d%95%e7%bb%86%e8%83%9e%e6%8c%96%e6%8e%98%e6%80%9d%e8%b7%af%ef%bc%81%e5%8d%97%e6%98%8c%e5%a4%a7%e5%ad%a6%e4%bd%99%e9%b9%8f%e5%9b%a2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=57318","title":{"rendered":"\u8fd8\u6709\u9ad8\u624b\uff1f\u6700\u65b0\u5355\u7ec6\u80de\u6316\u6398\u601d\u8def\uff01\u5357\u660c\u5927\u5b66\u4f59\u9e4f\u56e2\u961f7.1\u5206\uff1a\u673a\u5668\u5b66\u4e60+\u591a\u7ec4\u5b66\u6574\u5408+\u9884\u540e\u9884\u6d4b\uff0c\u6548\u679c\u6760\u6760\u6ef4\uff01"},"content":{"rendered":"


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style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">2\uff0c<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u672c\u6587\u4e2d\u4e0d\u4ec5\u7ed3\u5408\u4e86<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u57fa\u56e0\u7ec4\u5b66<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u3001<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u6279\u91cf\u8f6c\u5f55\u7ec4<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u548c<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\uff0c\u8fd8\u5229\u7528\u8fd9\u4e9b\u6570\u636e\u6765\u6784\u5efa\u66f4\u5168\u9762\u7684\u751f\u7269\u4fe1\u606f\u5b66\u6a21\u578b\uff0c\u63d0\u4f9b\u4e86\u5bf9CM\u66f4\u6df1\u5c42\u6b21\u7684\u7406\u89e3\u548c\u7ba1\u7406\uff1b<\/span><\/span><\/p>\n<p style=\"margin-left: 0pt;text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">3\uff0c<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u672c\u6587\u6784\u5efa\u4e86\u4e00\u4e2a<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u4e34\u5e8a\u8bfa\u83ab\u56fe<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\uff0c\u8fd9\u662f\u4e00\u4e2a\u7efc\u5408\u591a\u4e2a\u4e34\u5e8a\u6307\u6807\u548cCDI\u6a21\u578b\u7684\u5de5\u5177\uff0c\u7528\u4ee5\u63d0\u9ad8\u5bf9CM\u60a3\u8005\u751f\u5b58\u7ed3\u679c\u9884\u6d4b\u7684\u51c6\u786e\u6027\uff1b<\/span><\/span><\/p>\n<p style=\"margin-left: 0pt;text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">4\uff0c<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u672c\u7814\u7a76\u5bf9CDI\u6a21\u578b\u4e2d\u7684\u5173\u952e\u751f\u7269\u6807\u5fd7\u7269\u5728\u5b9e\u9645\u4e34\u5e8a\u6837\u672c\u4e2d\u8fdb\u884c\u9a8c\u8bc1\uff0c\u786e\u4fdd\u4e86\u6a21\u578b\u7684\u5b9e\u9a8c\u57fa\u7840\u548c\u4e34\u5e8a\u5e94\u7528\u7684\u53ef\u9760\u6027\u3002\u60f3\u8981\u53d1\u8868\u9ad8\u5206SCI\u7684\u5c0f\u4f19\u4f34\u4eec\u4e5f\u53ef\u4ee5\u501f\u9274\u4e00\u4e0b\u672c\u6587\u7684\u7814\u7a76\u601d\u8def\u54e6~ <\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(255, 0, 0);font-weight: bold;\">(ps\uff1a\u5982\u4f55<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(255, 0, 0);font-weight: bold;\">\u66f4\u597d\u7684\u5c06\u5355\u7ec6\u80de\u6316\u6398\u548c\u673a\u5668\u5b66\u4e60\u8f7b\u677e\u590d\u73b0\u5e76\u4e14\u5e94\u7528\u5230\u4e34\u5e8a\u533b\u5b66\u836f\u5b66\u76f8\u5173\u9886\u57df\u5462\uff1f\u6709\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u5feb\u626b\u7801\u4ea4\u6d41\u5427\uff01\uff01)\u3002<\/span>  <\/span><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018213\" data-ratio=\"1\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 185px;height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-52.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'\" data-recalc-dims=\"1\" \/><span style=\"font-size: var(--articleFontsize);letter-spacing: 0.034em;text-align: justify;text-indent: 0em;\"><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010797\" data-ratio=\"0.48703703703703705\" data-type=\"png\" data-w=\"1080\" height=\"269 .3999938964844\" width=\"552 .6799926757812\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_bibRRHDzIUgMC4Kw2jP19YJEmnV3RA.png?resize=552%2C269\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRb1aiaPNp6YayM6xanvBh8U9C2MeIkYAs5tzwl7DOuedpb3ZbibRRHDzIUgMC4Kw2jP19YJEmnV3RA\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 21pt;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u9898\u76ee\uff1a\u63a2\u7d22\u4e00\u79cd\u7279\u6b8a\u7684\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u6a21\u5f0f\uff0c\u901a\u8fc7\u673a\u5668\u5b66\u4e60\u9884\u6d4b\u76ae\u80a4\u9ed1\u8272\u7d20\u7624\u514d\u75ab\u6cbb\u7597\u7684\u9884\u540e\u548c\u654f\u611f\u6027<\/span><\/span><\/p>\n<p style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 21pt;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6742\u5fd7\uff1aApoptosis<\/span><\/span><\/p>\n<p style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 21pt;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">7.2<\/span><\/span><\/p>\n<p style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 21pt;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e74<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">4<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6708<\/span><\/span><\/p>\n<p style=\"text-align: justify;font-size: 10.5pt;font-family: \u7b49\u7ebf;font-weight: normal;margin-left: 21pt;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\"><span style=\"outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);font-size: 16px;\"><span style=\"outline: 0px;font-weight: 700;text-indent: -28px;font-family: system-ui, -apple-system, "system-ui", "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;color: rgb(0, 82, 255);letter-spacing: 0.544px;\"><\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u7814\u7a76\u80cc\u666f<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);\">\u4f5c\u8005\u4e3b\u8981\u5173\u6ce8\u76ae\u80a4\u9ed1\u8272\u7d20\u7624\uff08CM\uff09\uff0c\u8d77\u6e90\u4e8e\u9ed1\u8272\u7d20\u7ec6\u80de\u3002\u7d2b\u5916\u7ebf\u66b4\u9732\u3001\u9057\u4f20\u56e0\u7d20\u4e0e\u6bcf\u5e74CM\u7684\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u4e0a\u5347\u6709\u5173\uff0c\u5c3d\u7ba1\u514d\u75ab\u7597\u6cd5\u548c\u9776\u5411\u6cbb\u7597\u5df2\u7ecf\u6539\u5584\u4e86\u65e0\u6cd5\u901a\u8fc7\u624b\u672f\u79fb\u9664\u7684\u665a\u671f\u9ed1\u8272\u7d20\u7624\uff0c\u5e76\u4e14\u8fd9\u4e24\u79cd\u7b56\u7565\u76f8\u6bd4\u5316\u7597\u90fd\u663e\u8457\u63d0\u9ad8\u4e86\u751f\u5b58\u7387\uff0c\u4f46CM\u7684\u6cbb\u7597\u65e0\u6548\u548c\u9884\u540e\u4e0d\u826f\u7684\u6311\u6218\u4f9d\u7136\u5b58\u5728\uff0c\u8fd9\u5f3a\u8c03\u4e86\u8fdb\u4e00\u6b65\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u548c\u7814\u7a76\u7684\u5fc5\u8981\u6027\u3002\u514d\u75ab\u7597\u6cd5\u5728\u6cbb\u7597CM\u65b9\u9762\u7684\u6709\u6548\u6027\u6e90\u4e8e\u5176\u9ad8\u514d\u75ab\u539f\u6027\uff0c\u4f46\u968f\u7740\u80bf\u7624\u7ec6\u80de\u7684\u9002\u5e94\uff0c\u5b83\u4eec\u53ef\u80fd\u5bf9\u514d\u75ab\u7597\u6cd5\u4ea7\u751f\u62b5\u6297\u3002\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\uff08<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(0, 0, 0);\">PCD<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);\">\uff09\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u548c\u6269\u6563\u3002\u4e3a\u4e86\u9632\u6b62\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u9003\u907f\u7ec6\u80de\u6b7b\u4ea1\u5e76\u6301\u7eed\u589e\u6b96\uff0c\u6df1\u5165\u4e86\u89e3\u8fd9\u4e9b\u7ec6\u80de\u6b7b\u4ea1\u6a21\u5f0f\u5bf9\u4e8e\u5f00\u53d1\u66f4\u6709\u6548\u7684\u6cbb\u7597\u7b56\u7565\u81f3\u5173\u91cd\u8981\u3002\u6240\u4ee5\u4f5c\u8005\u63d0\u51fa\u4e86\u4e00\u4e2a\u65b0\u7684\u6807\u5fd7\u7269\uff0c\u7ec6\u80de\u6b7b\u4ea1\u6307\u6570\uff08CDI\uff09\uff0c\u7528\u4e8e\u8bc4\u4f30\u9884\u540e\u3001\u5f02\u8d28\u6027\u53ca\u5bf9\u4e0d\u540c\u6cbb\u7597\u7b56\u7565\u7684\u54cd\u5e94\u3002<\/span>    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010800\" data-ratio=\"0.8324074074074074\" data-type=\"png\" data-w=\"1080\" height=\"460 .6099853515625\" width=\"553 .3400268554688\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_ia2NvgzRicyHB6sTsUFzePuCnlHnxQ.png?resize=553%2C460\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRb1aiaPNp6YayM6xanvBh8UVILSk2W4YLEBOodrMu3MI0iaD4sia2NvgzRicyHB6sTsUFzePuCnlHnxQ\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">1 <\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u7814\u7a76\u7684\u7a0b\u5e8f\u6846\u67b6<\/span><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6570\u636e\u6765\u6e90<\/span><\/p>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"635\" style=\"border-width: initial;border-style: none;border-color: initial;border-collapse: collapse;background: transparent;width: 100%;\">\n<tbody>\n<tr>\n<td width=\"91\" valign=\"top\" style=\"width:68.05pt;background:#5B9BD5;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p style=\"margin: 8px 0pt 0px;text-align: justify;break-after: auto;text-indent: 0em;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-weight: bold;letter-spacing: 1px;\">\u6570\u636e\u96c6<\/span><\/p>\n<\/td>\n<td width=\"234\" valign=\"top\" style=\"width:175.6pt;background:#5B9BD5;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p style=\"margin: 8px 0pt 0px;text-align: justify;break-after: auto;text-indent: 0em;line-height: 1.6em;\"><span style=\"font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6570\u636e\u5e93<\/span><\/p>\n<\/td>\n<td width=\"234\" valign=\"top\" style=\"width:175.6pt;background:#5B9BD5;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p style=\"margin: 8px 0pt 0px;text-align: justify;break-after: auto;text-indent: 0em;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-weight: bold;letter-spacing: 1px;\">\u8be6\u7ec6\u4fe1\u606f<\/span><\/p>\n<\/td>\n<td width=\"76\" valign=\"top\" style=\"width:56.7pt;background:#5B9BD5;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:none;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p style=\"margin: 8px 0pt 0px;text-align: justify;break-after: auto;text-indent: 0em;line-height: 1.6em;\"><span style=\"font-family: "Microsoft YaHei UI";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6570\u91cf<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"91\" valign=\"top\" style=\"width:68.05pt;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p style=\"margin: 8px 0pt 0px;text-align: justify;break-after: auto;text-indent: 0em;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-size: 16px;letter-spacing: 1px;\">\u80bf\u7624\u6837\u672c<\/span><\/p>\n<\/td>\n<td width=\"234\" valign=\"top\" style=\"width:175.6pt;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p style=\"margin: 8px 0pt 0px;text-align: justify;break-after: auto;text-indent: 0em;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-size: 16px;letter-spacing: 1px;\">TCGA\u3001GEO\u3001TIGER<\/span><\/p>\n<\/td>\n<td width=\"234\" valign=\"top\" style=\"width:175.6pt;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p style=\"margin: 8px 0pt 0px;text-align: justify;break-after: auto;text-indent: 0em;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-size: 16px;letter-spacing: 1px;\">\u6db5\u76d612\u4e2a\u4e0d\u540c\u961f\u5217\uff08\u88681\uff09<\/span><\/p>\n<\/td>\n<td width=\"76\" valign=\"top\" style=\"width:56.7pt;background:#DEEAF6;border-top:solid #9CC2E5 1.0pt;mso-border-top-alt:solid #9CC2E5 0.5pt;border-left:solid #9CC2E5 1.0pt;mso-border-left-alt:solid #9CC2E5 0.5pt;border-bottom:solid #9CC2E5 1.0pt;mso-border-bottom-alt:solid #9CC2E5 0.5pt;border-right:solid #9CC2E5 1.0pt;mso-border-right-alt:solid #9CC2E5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<p style=\"margin: 8px 0pt 0px;text-align: justify;break-after: auto;text-indent: 0em;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(51, 51, 51);font-size: 16px;letter-spacing: 1px;\">1831<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u88681<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">12\u4e2a\u7814\u7a76\u961f\u5217\u7684\u8be6\u7ec6\u4fe1\u606f<\/span>    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010798\" data-ratio=\"0.5407407407407407\" data-type=\"png\" data-w=\"1080\" height=\"298 .94000244140625\" width=\"553 .010009765625\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_9mFdCdGpyKZhFhL7g4QIonudbTiaJA.png?resize=553%2C298\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRb1aiaPNp6YayM6xanvBh8UaVeX45Kd3yxUvv13VsqJ3weiaq9mFdCdGpyKZhFhL7g4QIonudbTiaJA\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u7814\u7a76\u601d\u8def<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);\">\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u9996\u5148\u4ece\u4e09\u4e2a\u516c\u5171\u6570\u636e\u5e93\u4e0b\u8f7d\u4e861831\u4e2a\u80bf\u7624\u6837\u672c\uff0c\u6db5\u76d612\u4e2a\u4e0d\u540c\u7684\u961f\u5217\uff0c\u5305\u62ec\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\uff08TCGA\uff09\u3001\u57fa\u56e0\u8868\u8fbe\u7efc\u5408\u6570\u636e\u5e93\uff08GEO\uff09\u548c\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u57fa\u56e0\u8868\u8fbe\u8d44\u6e90\uff08TIGER\uff09\uff0c\u540c\u65f6\u4e0b\u8f7d\u4e86813\u4e2a\u6b63\u5e38\u76ae\u80a4\u7ec4\u7ec7\u7684\u8f6c\u5f55\u7ec4\u6570\u636e\u7528\u4e8e\u6bd4\u5bf9\u3002\u901a\u8fc7\u8fd9\u4e9b\u6570\u636e\uff0c\u4f5c\u8005\u5173\u6ce8\u4e8ePCD\u7684\u591a\u79cd\u5f62\u5f0f\uff0c\u6536\u96c6\u4e86\u4e0ePCD\u76f8\u5173\u76841515\u4e2a\u57fa\u56e0\uff0c\u5e76\u901a\u8fc7\u5355\u6837\u672c\u57fa\u56e0\u96c6\u5bcc\u96c6\u5206\u6790\uff08ssGSEA\uff09\u6765\u8bc4\u4f30\u6bcf\u79cdPCD\u6a21\u5f0f\u7684\u6743\u91cd\u3002\u4f5c\u8005\u91c7\u7528\u4e00\u5143Cox\u56de\u5f52\u5206\u6790\u548cKaplan-Meier\u66f2\u7ebf\u6765\u68c0\u6d4b\u6bcf\u79cdPCD\u6a21\u5f0f\u7684\u9884\u540e\u7279\u6027\u3002\u901a\u8fc7\u5171\u8bc6\u805a\u7c7b\u5206\u6790\uff0c\u4f5c\u8005\u8bc6\u522b\u4e86\u4e0ePCD\u76f8\u5173\u7684CM\u4e9a\u7fa4\uff0c\u5e76\u8fdb\u4e00\u6b65\u8bc4\u4f30\u4e86\u8fd9\u4e9b\u4e9a\u7fa4\u5728\u514d\u75ab\u6cbb\u7597\u54cd\u5e94\u65b9\u9762\u7684\u5dee\u5f02\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u5bf9TCGA-SKCM\u961f\u5217\u8fdb\u884cTIDE\u8bc4\u5206\u4ee5\u9884\u6d4b\u60a3\u8005\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u54cd\u5e94\uff0c\u5e76\u6bd4\u8f83\u4e86\u4e0d\u540cPCD\u76f8\u5173\u4e9a\u7fa4\u95f4\u7684\u529f\u80fd\u548c\u9884\u540e\u5dee\u5f02\u3002\u4f5c\u8005\u8fd8\u8fd0\u7528\u591a\u79cd\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u5efa\u7acb\u4e86\u57fa\u4e8ePCD\u7279\u5f81\u7684\u9884\u540e\u6a21\u578b\uff0c\u5e76\u901a\u8fc7\u591a\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\uff0c\u7ed3\u5408\u8868\u8fbe\u503c\u548c\u76f8\u5173\u7cfb\u6570\uff0c\u6784\u5efa\u4e86\u7ec6\u80de\u6b7b\u4ea1\u6307\u6570\uff08CDI\uff09\u6a21\u578b\u6765\u9884\u6d4bCM\u60a3\u8005\u7684\u9884\u540e\u7279\u5f81\u3002\u6700\u540e\uff0c\u4f5c\u8005\u901a\u8fc7\u529f\u80fd\u5bcc\u96c6\u5206\u6790\u548c\u5355\u7ec6\u80de\u6570\u636e\u5206\u6790\u8fdb\u4e00\u6b65\u63a2\u8ba8\u4e86PCD\u5728\u4e0d\u540c\u7ec6\u80de\u4e9a\u7fa4\u4e2d\u7684\u8868\u8fbe\u548c\u5f71\u54cd\uff0c\u4ee5\u53ca\u901a\u8fc7\u5404\u79cd\u4e34\u5e8a\u4fe1\u606f\u6784\u5efa\u4e86\u7efc\u5408\u7684\u9884\u540e\u540d\u6a21\u56fe\u4ee5\u9a8c\u8bc1CDI\u4f5c\u4e3a\u72ec\u7acb\u9884\u540e\u56e0\u7d20\u7684\u6709\u6548\u6027\u3002<\/span>    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u4e3b\u8981\u7ed3\u679c<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">1. CM\u4e2dPCD<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u7684\u603b\u4f53\u666f\u89c2<\/span><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);\">\u4e3a\u4e86\u5168\u9762\u63a2\u7d22CM\u4e2dPCD\u7684\u666f\u89c2\uff0c\u4f5c\u8005\u5728TCGA-SKCM\u961f\u5217\u4e2d\u4f7f\u7528\u5305\u542b1515\u4e2aPCD\u7684\u57fa\u56e0\u96c6\u6765\u8ba1\u7b9714\u79cdPCD\u6a21\u5f0f\u6c34\u5e73\u3002\u57fa\u4e8e\u8fd9\u4e9b\u7a0b\u5ea6\uff0c\u4f5c\u8005\u7ed8\u5236\u4e86\u6bcf\u79cdPCD\u6a21\u5f0f\u7684Kaplan-Meier\u66f2\u7ebf\uff0c\u4ee5\u5c55\u793aPCD\u5728CM\u4e2d\u7684\u9884\u540e\u7279\u6027\u3002\u5927\u90e8\u5206\u6a21\u5f0f\u5747\u663e\u793a\u51fa\u663e\u8457\u7684\u9884\u540e\u4f5c\u7528\u3002\u4f5c\u8005\u8fdb\u884c\u4e86\u5355\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\uff0c\u5c06\u786b\u952e\u6b7b\u4ea1\u8bc6\u522b\u4e3a\u6700\u663e\u8457\u7684\u98ce\u9669\u56e0\u7d20\uff0c\u800c\u574f\u6b7b\u3001\u70ed\u51cb\u4ea1\u3001\u51cb\u4ea1\u548c\u81ea\u566c\u88ab\u5b9a\u4e49\u4e3a\u4e3b\u8981\u7684\u4fdd\u62a4\u56e0\u7d20\uff08\u56fe2\uff09\u3002<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: bold;\">\u56e0\u6b64\uff0c\u8fd9\u4e94\u79cd\u663e\u8457\u7684PCD\u6a21\u5f0f\u88ab\u9009\u4e3a\u540e\u7eed\u5206\u6790\u7684\u5bf9\u8c61\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010801\" data-ratio=\"0.45\" data-type=\"png\" data-w=\"1080\" height=\"248 .79998779296875\" width=\"553 .1400146484375\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_zwtz5UcBNFB1sE9kVibhAmr0vbEULA.png?resize=553%2C248\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRb1aiaPNp6YayM6xanvBh8UDiawjFAum9icKLYLFuRuicQTkWP7zwtz5UcBNFB1sE9kVibhAmr0vbEULA\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">2 <\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5168\u9762\u63a2\u7d22PCD\u6a21\u5f0f\u7684\u9884\u540e\u666f\u89c2<\/span><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">2. <\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u83b7\u5f97\u4e24\u4e2a\u4e0d\u540c\u7684PCD\u76f8\u5173\u7684CM\u7c07\uff0c\u5e76\u63a2\u7d22\u4e24\u4e2a\u7c07\u4e4b\u95f4\u7684\u9884\u540e\u548c\u514d\u75ab\u6cbb\u7597<\/span><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);\">\u6839\u636e\u4e94\u79cdPCD\u6a21\u5f0f\u7684ssGSEA\u7a0b\u5ea6\uff0c\u5bf9TCGA-SKCM\u961f\u5217\u4e2d\u7684\u6240\u6709457\u4e2a\u80bf\u7624\u6837\u672c\u57fa\u4e8eK\u503c\u8fdb\u884c\u4e86\u805a\u7c7b\uff0c\u88ab\u5206\u4e3a\u4e24\u4e2a\u4e0d\u540c\u7684PCD\u76f8\u5173\u7c07\uff0c\u5bf9\u5e94\u7684CM\u96c6\u5408\u4e3aC1\u548cC2\u3002\u4e24\u4e2a\u7c07\u4e4b\u95f4\u5728\u9884\u540e\u7279\u5f81\u4e0a\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff0cC1\u7684\u603b\u751f\u5b58\u671f\u548c\u75be\u75c5\u7279\u5f02\u6027\u751f\u5b58\u671f\u5747\u4f18\u4e8eC2\uff0c\u8868\u660eC2\u4e0e\u8f83\u5dee\u7684\u9884\u540e\u76f8\u5173\u3002\u6b64\u5916\uff0c\u514d\u75ab\u6cbb\u7597\u7684\u54cd\u5e94\u7387\u5728C1\u4e2d\u9ad8\u4e8eC2\u3002C1\u7684\u529f\u80fd\u5931\u8c03\u5f97\u5206\u663e\u8457\u66f4\u9ad8\uff0c\u800c\u6392\u9664\u5f97\u5206\u663e\u8457\u66f4\u4f4e\u3002\u540c\u65f6\uff0c\u9884\u6d4b\u514d\u75ab\u6cbb\u7597\u6548\u679c\u7684\u4e24\u4e2a\u6807\u8bb0\u7269\uff0c\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u548c\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09\uff0c\u5728C1\u4e2d\u4e5f\u66f4\u9ad8\uff0c\u4e14C1\u4e2d9\u79cd\u5e38\u89c1\u514d\u75ab\u68c0\u67e5\u70b9\uff08ICKs\uff09\u7684\u8868\u8fbe\u6c34\u5e73\u5747\u663e\u8457\u9ad8\u4e8eC2\uff08\u56fe3\uff09\u3002<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: bold;\">C1\u76f8\u6bd4C2\u5728\u514d\u75ab\u6cbb\u7597\u7684\u654f\u611f\u6027\u548c\u6548\u679c\u4e0a\u66f4\u4e3a\u663e\u8457\u3002<\/span>    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010799\" data-ratio=\"1.0685185185185184\" data-type=\"png\" data-w=\"1080\" height=\"543 .4099731445312\" width=\"508 .5400085449219\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_ylldxLusHUicddLLWWyc40ZCbbAPvg.png?resize=508%2C543\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRb1aiaPNp6YayM6xanvBh8UWGMGib9XJ0SOIt6duicoRgy31aYylldxLusHUicddLLWWyc40ZCbbAPvg\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">\u56fe3 PCD\u76f8\u5173\u7684\u4e24\u4e2aCM\u7c07\u7684\u8bc6\u522b<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">3. <\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u4e24\u4e2aPCD\u76f8\u5173\u7c07\u7684\u5dee\u5f02<\/span><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;\">\u4e24\u4e2aPCD\u96c6\u5408\uff08C1\u548cC2\uff09\u5728\u514d\u75ab\u6cbb\u7597\u666f\u89c2\u4e2d\u7684\u663e\u8457\u5dee\u5f02\uff0c\u5e76\u4e14C1\u4e2d\u514d\u75ab\u7ec6\u80de\u7684\u6d78\u6da6\u663e\u8457\u66f4\u4e3a\u4e30\u5bcc\u3002\u6b64\u5916\uff0c\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\uff0c\u4f5c\u4e3a\u9884\u6d4b\u9ed1\u8272\u7d20\u7624\u514d\u75ab\u6cbb\u7597\u6548\u679c\u7684\u53e6\u4e00\u4e2a\u5173\u952e\u751f\u7269\u6807\u5fd7\u7269\uff0c\u4e5f\u5728\u4e24\u4e2a\u96c6\u5408\u4e2d\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u4e3a\u4e86\u5168\u9762\u63a2\u7d22TME\u7684\u7279\u6027\uff0c\u4f5c\u8005\u91c7\u7528\u4e86\u56db\u79cd\u7b97\u6cd5\u8fdb\u884c\u5206\u6790\u3002ssGSEA\u7b97\u6cd5\u663e\u793a\uff0c\u4e0eC2\u76f8\u6bd4\uff0cC1\u96c6\u5408\u7684\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u663e\u8457\u66f4\u4e3a\u4e30\u5bcc\u3002\u540c\u65f6\uff0c\u901a\u8fc7ESTIMATE\u7b97\u6cd5\u8ba1\u7b97\u7684Stromal\u5f97\u5206\u3001\u514d\u75ab\u5f97\u5206\u548cESTIMATE\u5f97\u5206\u5728C1\u4e2d\u4e5f\u90fd\u66f4\u9ad8\uff0c\u800c\u80bf\u7624\u7eaf\u5ea6\u5728C1\u4e2d\u66f4\u4f4e\uff0c\u8868\u660eC2\u4e2d\u7684CM\u80bf\u7624\u6076\u6027\u7a0b\u5ea6\u66f4\u9ad8\uff0cTME\u8f83\u5dee\u3002CIBERSORT\u7684\u7ed3\u679c\u4e5f\u5f3a\u8c03\u4e86C1\u4e0eC2\u76f8\u6bd4\u62e5\u6709\u66f4\u663e\u8457\u548c\u66f4\u4e30\u5bcc\u7684TME\u3002TIMER\u7b97\u6cd5\u5c55\u793a\u4e86C1\u4e2d6\u79cd\u514d\u75ab\u7ec6\u80de\u7684\u66f4\u9ad8\u6d78\u6da6\uff08\u56fe4\uff09\u3002<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u8fd9\u4e9b\u7ed3\u679c\u63ed\u793a\u4e86PCD\u76f8\u5173\u7c07C1\u4e2d\u80bf\u7624\u5fae\u73af\u5883\u7684\u6d3b\u8dc3\u6027\u5bf9\u63d0\u9ad8\u514d\u75ab\u6cbb\u7597\u7684\u6709\u6548\u6027\u5177\u6709\u5173\u952e\u610f\u4e49\u3002<\/span>    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010802\" data-ratio=\"1.339816933638444\" data-type=\"png\" data-w=\"874\" height=\"741 .280029296875\" width=\"553 .280029296875\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_A1ib7icxymVtdgv37JeaVPDVXQOnhw.png?resize=553%2C741\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRb1aiaPNp6YayM6xanvBh8UbJRVLqPyRRBx3sLMQlMoZ9vke7A1ib7icxymVtdgv37JeaVPDVXQOnhw\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">4 <\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4e24\u4e2a\u4e0ePCD\u76f8\u5173\u7684CM\u7c07\u4e4b\u95f4\u7684TME\u7684\u4e0d\u540c\u666f\u89c2\u3002<\/span><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">4. <\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u5171\u8bc6\u9884\u6d4b\u6a21\u578b\u6784\u5efa<\/span><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4e3a\u4e86\u63a2\u7d22\u4e24\u4e2aPCD\u96c6\u5408\uff08C1\u548cC2\uff09\u4e4b\u95f4\u7684\u514d\u75ab\u6cbb\u7597\u54cd\u5e94\u5dee\u5f02\u4ee5\u53caPCD\u7684\u666f\u89c2\uff0c\u4f5c\u8005\u5728\u8f6c\u5f55\u7ec4\u6c34\u5e73\u4e0a\u8fdb\u884c\u4e86\u5dee\u5f02\u8868\u8fbe\u5206\u6790\u3002\u7ed3\u679c\u8bc6\u522b\u51fa963\u4e2a\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u3002\u5c06\u8fd9\u4e9bDEG\u4e0e\u4e94\u79cd\u663e\u8457PCD\u6a21\u5f0f\u76f8\u5173\u76841006\u4e2a\u57fa\u56e0\u91cd\u53e0\uff0c\u8bc6\u522b\u51fa56\u4e2a\u5173\u952ePCD\u7279\u5f81\u57fa\u56e0\u3002\u57fa\u4e8e\u8fd9\u4e9b\u5206\u6790\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u5f00\u53d1\u4e86\u4e00\u4e2a\u4ee5PCD\u4e3a\u4ecb\u5bfc\u7684\u9884\u540e\u6a21\u578b\uff0c\u79f0\u4e3aCDI\uff0c\u4ee5\u9610\u660ePCD\u5728CM\u514d\u75ab\u6cbb\u7597\u54cd\u5e94\u548c\u9884\u540e\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u3002\u9996\u5148\uff0c\u4f5c\u8005\u901a\u8fc7\u5355\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\uff0c\u7b5b\u9009\u51fa\u4e8647\u4e2a\u663e\u8457\u7684\u9884\u540e\u76f8\u5173PCD\u7279\u5f81\u3002\u7136\u540e\uff0c\u5229\u7528\u8fd947\u4e2a\u7279\u5f81\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u751f\u5b58\u65f6\u95f4\u548c\u72b6\u6001\u4f5c\u4e3a\u8f93\u5165\u6570\u636e\uff0c\u5e94\u7528101\u79cd\u7b97\u6cd5\u6a21\u5f0f\u7ec4\u5408\u901a\u8fc710\u79cd\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u5728TCGA-SKCM\u961f\u5217\u4e2d\u8fdb\u884c\u8bad\u7ec3\u3002\u6a21\u578b\u7ed3\u679c\u663e\u793a\uff0c\u9ad8CDI\u503c\u7684\u60a3\u8005\u53ef\u80fd\u8868\u73b0\u51fa\u8f83\u5dee\u7684\u9884\u540e\uff08\u56fe5\uff09\u3002<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u8fd9\u4e00\u7814\u7a76\u8868\u660e\uff0cPCD\u7279\u5f81\u548cCDI\u6a21\u578b\u5728\u9884\u6d4b\u548c\u6539\u8fdbCM\u60a3\u8005\u7684\u6cbb\u7597\u7ed3\u679c\u65b9\u9762\u5177\u6709\u6f5c\u5728\u7684\u91cd\u8981\u4ef7\u503c\u3002<\/span>    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010805\" data-ratio=\"0.8814814814814815\" data-type=\"png\" data-w=\"1080\" height=\"488 .0700378417969\" width=\"553 .4099731445312\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_xcOtoR7xCCrDMicGWSYY7OICUaglIQ.png?resize=553%2C488\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRb1aiaPNp6YayM6xanvBh8U6HGLianPQRicJgNrOFN8icj6OhgVxcOtoR7xCCrDMicGWSYY7OICUaglIQ\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe5\u6784\u5efa\u548c\u9a8c\u8bc1\u9884\u540e\u7279\u5f81<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">5. <\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u5bf9CDI\u6a21\u578b\u7684\u9884\u6d4b\u51c6\u786e\u6027\u548c\u751f\u7269\u5b66\u7279\u6027\u7684\u7cfb\u7edf\u63a2\u7d22<\/span>    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u6536\u96c6\u4e8639\u4e2a\u5148\u524d\u53d1\u8868\u7684\u4e0e\u5404\u79cd\u751f\u7269\u8fc7\u7a0b\u76f8\u5173\u7684\u9884\u540e\u6a21\u578b\u3002\u968f\u540e\uff0c\u4f5c\u8005\u5728\u6240\u6709\u9884\u540e\u6a21\u578b\u7684\u8bad\u7ec3\u96c6\u3001\u6d4b\u8bd5\u96c6\u548c\u9a8c\u8bc1\u96c6\u4e0a\u8fdb\u884c\u4e86\u5355\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\u3002\u5176\u4e2d\u53ea\u6709\u4e03\u4e2a\u6a21\u578b\uff0c\u5305\u62ecCDI\uff0c\u88ab\u786e\u8ba4\u4e3a\u5728\u6240\u6709\u56db\u4e2a\u961f\u5217\u4e2d\u4e00\u81f4\u7684\u98ce\u9669\u56e0\u7d20\uff0c\u51f8\u663e\u4e86\u4f5c\u8005CDI\u6a21\u578b\u7684\u51c6\u786e\u6027\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u6bd4\u8f83\u4e86\u6bcf\u4e2a\u6a21\u578b\u7684C\u6307\u6570\u4e0eCDI\u6a21\u578b\u7684C\u6307\u6570\uff0c\u5e76\u89c2\u5bdf\u5230\u53ea\u6709CDI\u5728\u8bad\u7ec3\u96c6\u3001\u6d4b\u8bd5\u96c6\u548c\u9a8c\u8bc1\u96c6\u4e2d\u8868\u73b0\u51fa\u4f18\u8d8a\u6027\u3002\u5176\u4ed6\u4e00\u4e9b\u6a21\u578b\u4ec5\u5728\u5176\u5404\u81ea\u7684\u8bad\u7ec3\u96c6\u4e2d\u663e\u793a\u51fa\u51c6\u786e\u7684\u9884\u6d4b\uff08\u9ad8C\u6307\u6570\uff09\uff0c\u8fdb\u4e00\u6b65\u7a81\u51fa\u4e86CDI\u7684\u4f18\u8d8a\u7279\u6027\uff08\u56fe6\uff09\u3002<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u8fd9\u4e00\u7814\u7a76\u8868\u660e\uff0cCDI\u6a21\u578b\u5728\u9884\u6d4bCM\u60a3\u8005\u7684\u9884\u540e\u65b9\u9762\u5177\u6709\u663e\u8457\u7684\u6709\u6548\u6027\u548c\u666e\u9002\u6027\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010804\" data-ratio=\"0.7814814814814814\" data-type=\"png\" data-w=\"1080\" height=\"432 .010009765625\" width=\"552 .8099975585938\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_HXJEH5kWZafEcZom0Fc1eLlHw2C7PA.png?resize=552%2C432\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRb1aiaPNp6YayM6xanvBh8UdGUkyylrIrdhQNApicAtiaNSo9HXJEH5kWZafEcZom0Fc1eLlHw2C7PA\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe6\u6bd4\u8f83CDI\u7279\u5f81\u4e0e\u5176\u4ed6\u5df2\u53d1\u8868\u7684CM\u6a21\u578b\u4e4b\u95f4\u7684\u9884\u540e\u51c6\u786e\u6027\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">6. <\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u5728CDI\u6a21\u578b\u4e2d\u7684\u514d\u75ab\u666f\u89c2\u548c\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u7684\u51c6\u786e\u9884\u6d4b<\/span><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4e3a\u4e86\u63a2\u7d22\u901a\u8fc7CDI\u4ecb\u5bfc\u7684\u514d\u75ab\u666f\u89c2\uff0c\u4f5c\u8005\u9996\u5148\u5728GSE115978\u6570\u636e\u96c6\u4e2d\u7814\u7a76\u4e86\u5355\u7ec6\u80de\u6c34\u5e73\u4e0aCDI\u7684\u7279\u5b9a\u5206\u5e03\u3002\u5728\u5bf9\u8d28\u91cf\u8f83\u5dee\u7684\u7ec6\u80de\u8fdb\u884c\u7b5b\u9009\u540e\uff0c\u8bc6\u522b\u51fa10\u79cd\u4e3b\u8981\u7ec6\u80de\u7c7b\u578b\u3002\u51e0\u4e4e\u6240\u6709\u7ec6\u80de\u7c7b\u578b\u4e2d\u7684CDI\u6c34\u5e73\u90fd\u8f83\u9ad8\u3002\u4f5c\u8005\u89c2\u5bdf\u5230\u9ad8CDI\u7ec4\u663e\u793a\u51fa\u66f4\u9ad8\u6bd4\u4f8b\u7684\u591a\u6837\u5316T\u7ec6\u80de\uff0c\u800c\u5176\u4ed6\u7ec6\u80de\u7c7b\u578b\u5728\u4f4eCDI\u7ec4\u4e2d\u66f4\u4e3a\u666e\u904d\uff0c\u8fd9\u4e0e\u5bcc\u96c6\u5206\u6790\u7684\u7ed3\u679c\u4e00\u81f4\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u6bd4\u8f83\u4e86\u9ad8\u548c\u4f4eCDI\u7ec4\u4e4b\u95f4\u7684\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u548c\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09\uff0c\u53d1\u73b0\u8fd9\u4e24\u4e2a\u9884\u6d4b\u514d\u75ab\u6cbb\u7597\u6548\u679c\u7684\u6807\u8bb0\u5728\u4f4eCDI\u7ec4\u4e2d\u8f83\u9ad8\uff08\u56fe7\uff09\u3002<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u7ed3\u679c\u5f3a\u8c03\u4e86CDI\u5728\u7406\u89e3\u548c\u9884\u6d4b\u9ed1\u8272\u7d20\u7624\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u6f5c\u5728\u4ef7\u503c\u3002<\/span>    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010803\" data-ratio=\"0.7925925925925926\" data-type=\"png\" data-w=\"1080\" height=\"438 .27001953125\" width=\"553 .0800170898438\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_0viaWIBKmtQoia10yLHAY5q9RwpaPg.png?resize=553%2C438\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRb1aiaPNp6YayM6xanvBh8Un5JEFrLfrdMs3ib2lxnBpvmqSIv0viaWIBKmtQoia10yLHAY5q9RwpaPg\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe7<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">CDI\u5728CM\u548c\u5176\u4ed6\u764c\u75c7\u961f\u5217\u4e2d\u7684\u9884\u6d4b\u7279\u5f81<\/span><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86\u5176\u5728\u56db\u4e2aCM\u60a3\u8005\u961f\u5217\u4e2d\u9884\u6d4b\u54cd\u5e94\u7684\u80fd\u529b\u3002\u4f4eCDI\u7684\u60a3\u8005\u663e\u793a\u51fa\u66f4\u9ad8\u7684\u514d\u75ab\u6cbb\u7597\u54cd\u5e94\u53ef\u80fd\u6027\uff0c\u4f4eCDI\u7ec4\u7684\u54cd\u5e94\u7387\u5728\u56db\u4e2a\u961f\u5217\u4e2d\u5747\u663e\u8457\u66f4\u9ad8\u3002\u4f5c\u8005\u5c06CDI\u6a21\u578b\u7684\u9884\u6d4b\u7279\u6027\u6269\u5c55\u5230\u5176\u4ed6\u764c\u75c7\uff0c\u6536\u96c6\u4e86\u56db\u4e2a\u5176\u4ed6\u764c\u75c7\u7684\u514d\u75ab\u6cbb\u7597\u961f\u5217\u3002CDI\u6a21\u578b\u5728\u6240\u6709\u56db\u4e2a\u961f\u5217\u4e2d\u5c55\u793a\u4e86\u663e\u8457\u7684\u9884\u540e\u4f5c\u7528\uff0c\u9ad8CDI\u7684\u60a3\u8005\u4e0e\u8f83\u5dee\u7684\u9884\u540e\u76f8\u5173\u3002\u540c\u6837\uff0c\u4f4eCDI\u7ec4\u7684\u54cd\u5e94\u7387\u4e5f\u66f4\u9ad8\uff08\u56fe8\uff09\u3002<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u7ed3\u679c\u8bc1\u5b9e\u4e86CDI\u6a21\u578b\u5728\u9884\u6d4b\u591a\u79cd\u764c\u75c7\u60a3\u8005\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u65b9\u9762\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u6f5c\u529b\u3002<\/span>    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010806\" data-ratio=\"1.3921800947867298\" data-type=\"png\" data-w=\"844\" height=\"770 .8099365234375\" width=\"553 .6799926757812\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_lC6DKs1NjN5fp0wr7UkKsmUuO0UIuw.png?resize=553%2C770\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRb1aiaPNp6YayM6xanvBh8U0JTiaTeiaUtqMZ1z7IXsfn8CpglC6DKs1NjN5fp0wr7UkKsmUuO0UIuw\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe8<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">CDI\u5728TME\u548c\u514d\u75ab\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528<\/span>    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;\">6. <\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u5f3a\u8c03CDI\u7684\u9884\u540e\u4f5c\u7528\uff0c\u5e76\u5c06\u8bfa\u83ab\u6839\u98ce\u9669\u6a21\u578b\u4e0e\u4e34\u5e8a\u4fe1\u606f\u7684\u6574\u5408<\/span><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4e3a\u4e86\u51cf\u5c11\u4ec5\u4f9d\u8d56CDI\u9884\u6d4bCM\u60a3\u8005\u9884\u540e\u7684\u4e0d\u7a33\u5b9a\u6027\u548c\u6f5c\u5728\u504f\u89c1\uff0c\u4f5c\u8005\u6269\u5c55\u4e86\u5206\u6790\u8303\u56f4\uff0c\u5c06\u4e94\u4e2a\u4e34\u5e8a\u6307\u6807\u4e0eCDI\u4e00\u8d77\u6df1\u5165\u9884\u6d4bCM\u7684\u9884\u540e\u3002\u9996\u5148\uff0c\u5355\u53d8\u91cf\u548c\u591a\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\u90fd\u5f3a\u8c03\u4e86CDI\u7684\u5173\u952e\u9884\u540e\u4f5c\u7528\u3002\u968f\u540e\uff0c\u4f5c\u8005\u6574\u5408\u4e86\u5404\u79cd\u4e34\u5e8a\u4fe1\u606f\u548cCDI\u8fdb\u884c\u591a\u53d8\u91cfCox\u56de\u5f52\u548c\u9010\u6b65\u56de\u5f52\u5206\u6790\uff0c\u6784\u5efa\u4e86TCGA-SKCM\u961f\u5217\u4e2d\u7684\u4e00\u4e2a\u7efc\u5408\u8bc4\u5206\u6a21\u578b\uff08\u8bfa\u83ab\u56fe\uff09\u3002\u57fa\u4e8e\u8bfa\u83ab\u56fe\u7684\u516c\u5f0f\uff0c\u8ba1\u7b97\u51fa\u6bcf\u4f4d\u60a3\u8005\u7684\u603b\u5206\uff0c\u5e76\u5728KM\u66f2\u7ebf\u4e2d\u5c55\u793a\u4e86\u8bfa\u83ab\u56fe\u7684\u9884\u540e\u7279\u6027\u3002\u7279\u5b9a\u65f6\u95f4\u95f4\u9694\u7684\u603b\u5206AUC\u4e00\u81f4\u6027\u6700\u9ad8\uff0c\u8fdb\u4e00\u6b65\u5f3a\u8c03\u4e86\u8bfa\u83ab\u56fe\u7684\u5173\u952e\u4f5c\u7528\uff08\u56fe9\uff09\u3002<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u8fd9\u4e00\u7814\u7a76\u8bc1\u660e\u4e86\u7ed3\u5408CDI\u548c\u4e34\u5e8a\u6307\u6807\u7684\u8bfa\u83ab\u56fe\u6a21\u578b\u5728\u63d0\u9ad8CM\u60a3\u8005\u9884\u540e\u9884\u6d4b\u51c6\u786e\u6027\u65b9\u9762\u5177\u6709\u663e\u8457\u4f18\u52bf\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010807\" data-ratio=\"0.49444444444444446\" data-type=\"png\" data-w=\"1080\" height=\"273 .60003662109375\" width=\"553 .4099731445312\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_rNPG31og0icJoYxsREwge6Z9HfAXRg.png?resize=553%2C273\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRb1aiaPNp6YayM6xanvBh8UPEYavzeDJZ34giapMGDiaADyPBYrNPG31og0icJoYxsREwge6Z9HfAXRg\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe9<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">CDI\u7684\u4e34\u5e8a\u7279\u5f81\u53ca\u4e34\u5e8a\u5217\u7ebf\u56fe\u7684\u6784\u5efa<\/span><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-weight: bold;letter-spacing: 1px;\">6. CDI\u6a21\u578b\u9884\u6d4b\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5bf9\u9776\u5411\u6cbb\u7597\u548c\u5316\u7597\u836f\u7269\u7684\u654f\u611f\u6027<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u8bc4\u4f30\u4e86\u4e24\u79cd\u5e38\u7528\u9776\u5411\u6cbb\u7597\u836f\u7269\u7684IC50\u503c\u3002\u5206\u6790\u663e\u793a\uff0c\u8fbe\u4f2f\u62c9\u82ac\u5728\u4f4eCDI\u7ec4\u4e2d\u7684IC50\u503c\u8f83\u4f4e\uff0c\u663e\u793a\u51fa\u4e0eCDI\u7684\u663e\u8457\u6b63\u76f8\u5173\uff0c\u800c\u66f2\u7f8e\u66ff\u5c3c\u5728\u9ad8CDI\u7ec4\u4e2d\u7684IC50\u503c\u8f83\u4f4e\uff0c\u4e5f\u5c55\u793a\u4e86\u4e0eCDI\u7684\u663e\u8457\u76f8\u5173\u6027\uff08\u56fe10\uff09\u3002<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u603b\u7684\u6765\u8bf4\uff0c\u4f4eCDI\u7684CM\u60a3\u8005\u53ef\u80fd\u5bf9BRAF\u6291\u5236\u5242\u6709\u66f4\u597d\u7684\u53cd\u5e94\uff0c\u800c\u9ad8CDI\u7684\u60a3\u8005\u53ef\u80fd\u66f4\u53ef\u80fd\u5bf9MEK\u6291\u5236\u5242\u6709\u53cd\u5e94\u3002<\/span>    <\/span><o:page><\/o:page><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u7b49\u7ebf;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010808\" data-ratio=\"0.7814814814814814\" data-type=\"png\" data-w=\"1080\" height=\"432 .8099670410156\" width=\"553 .47998046875\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/14_EFbRRUCIXxtmo6VGkibzribeqMVZJw.png?resize=553%2C432\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LRb1aiaPNp6YayM6xanvBh8UajVFq6M727yhictW1BcSsY9aNdaEFbRRUCIXxtmo6VGkibzribeqMVZJw\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe10\u63a2\u7d22CM\u7684\u6f5c\u5728\u6cbb\u7597\u7b56\u7565\u548c7\u4e2a\u5173\u952e\u6a21\u578b\u7279\u5f81\u7684\u9a8c\u8bc1<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: "Times New Roman";font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"letter-spacing: 1px;font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u5f15\u5165\u4e00\u4e2a\u65b0\u7684\u4e0ePCD\u76f8\u5173\u7684\u9884\u540e\u6807\u5fd7\u7269CDI\uff0c\u8be5\u6307\u6570\u5229\u7528\u4e86\u5728CM\u60a3\u8005\u4e2d\u6307\u5bfc\u6cbb\u7597\u65b9\u6cd5\u7684\u6f5c\u529b\u3002\u8fd9\u4e2a\u9884\u540e\u6807\u5fd7\u7269\u57fa\u4e8e\u4e03\u4e2aPCD\u76f8\u5173\u7279\u5f81\uff08CD28, CYP1B1, JAK3, LAMP3, SFN, STAT4, \u548c TRAF1\uff09\u3002CDI\u6a21\u578b\u63d0\u4f9b\u4e86\u5bf9\u9884\u540e\u3001\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u548c\u6cbb\u7597\u7b56\u7565\u7684\u6307\u5bfc\u3002\u6b64\u5916\uff0c\u8fd8\u6784\u5efa\u4e86\u4e34\u5e8a\u8bfa\u83ab\u56fe\u4ee5\u66f4\u51c6\u786e\u5730\u9884\u6d4b\u751f\u5b58\u7ed3\u679c\u3002\u53e6\u5916\uff0c\u8fd9\u4e03\u4e2aPCD\u76f8\u5173\u7279\u5f81\u5728\u5185\u90e8\u961f\u5217\u4e2d\u7684\u8868\u8fbe\u5f97\u5230\u4e86\u9a8c\u8bc1\uff0c\u8fdb\u4e00\u6b65\u5f3a\u8c03\u4e86\u5176\u6f5c\u5728\u7684\u51c6\u786e\u6027\u548c\u4e34\u5e8a\u610f\u4e49\u3002\u603b\u4f53\u4e0a\uff0c\u7ed3\u5408\u57fa\u56e0\u7ec4\u5b66\u3001\u6279\u91cf\u8f6c\u5f55\u7ec4\u548c\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\uff0c\u4f5c\u8005\u4e3a\u4e34\u5e8a\u667a\u80fd\u548c\u65b0\u7684CM\u7ba1\u7406\u65b9\u6cd5\u63d0\u4f9b\u4e86\u72ec\u7279\u7684\u673a\u4f1a\u3002<\/span><span style=\"letter-spacing: 1px;font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;background: rgb(255, 255, 0);\">\u8fd9\u7bc7\u673a\u5668\u5b66\u4e60\u7ed3\u5408\u4e34\u5e8a\u6570\u636e\u8fdb\u884c\u9884\u6d4b\u7684\u601d\u8def\u4e5f\u975e\u5e38\u5de7\u5999\uff01\u5c0f\u9014\u4e00\u76f4\u90fd\u5728\u4e0d\u65ad\u63a8\u9001\u6700\u65b0\u7684\u751f\u4fe1\u601d\u8def\u54e6\uff01\u5982\u679c\u4f60\u60f3\u8981\u5b66\u4e60\u8fd9\u4e9b\u601d\u8def\uff0c\u6216\u8005\u60f3\u8981\u5b9a\u5236\u66f4\u591a\u521b\u65b0\u6027\u601d\u8def\uff0c\u90a3\u4e48\u5c31\u76f4\u63a5\u8054\u7cfb\u5c0f\u9014\u5427\uff01<\/span><span style=\"letter-spacing: 1px;font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(255, 0, 0);font-weight: bold;background: rgb(255, 255, 0);\">\u6211\u4eec\u4f1a\u5168\u529b\u4ee5\u8d74\uff0c\u4e3a\u4f60\u7684\u79d1\u7814\u5de5\u4f5c\u63d0\u4f9b\u5e2e\u52a9\uff01\u901f\u901f\u8054\u7cfb\u5c0f\u9014\u5427~<\/span>  <\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\">  <\/span><\/p>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018220\" data-ratio=\"1\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-52.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'&from=appmsg\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018222\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/16_7TvAyUibd1TPhJmZfialJtv6tu2SEg-18.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-recalc-dims=\"1\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100018221\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/17_9N02aBaau07RufXeXRLmvAHsrFZxtw-16.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;margin-bottom: 0px;\"><br \/><\/p>\n<p style=\"display: none;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd8\u6709\u9ad8\u624b\uff1f\u6700\u65b0\u5355\u7ec6\u80de\u6316\u6398\u601d\u8def\uff01\u5357\u660c\u5927\u5b66\u4f59\u9e4f\u56e2\u961f7.1\u5206\uff1a\u673a\u5668\u5b66\u4e60+\u591a\u7ec4\u5b66\u6574\u5408+\u9884\u540e\u9884\u6d4b\uff0c\u6548\u679c\u6760\u6760\u6ef4\uff01 \u5c0f\u9014&n […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/57318"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=57318"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/57318\/revisions"}],"predecessor-version":[{"id":57335,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/57318\/revisions\/57335"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=57318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=57318"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=57318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}