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0px 5px 3px;\">\n<section style=\"text-align: center;transform: translate3d(2px, 0px, 0px);margin-top: -14px;margin-bottom: -14px;\" powered-by=\"xiumi.us\">\n<p>{ \u70b9\u51fb\u84dd\u5b57\uff0c\u5173\u6ce8\u6211\u4eec }<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u5e38\u7528\u7684\u6570\u636e\u5e93\uff0c\u4e3b\u8981\u4e3aOpenGWAS\u3001GWAS Catalog\u548cPhenoscanner\u4e09\u4e2a\u3002\u4eca\u5929\uff0c\u5c0f\u5e08\u59b9\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e00\u4e0b\u83b7\u53d6GWAS Catalog\u6570\u636e\u5e93\u6570\u636e\u7684\u201cgwasrapidd\u201d\u5305\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">gwasrapidd\u5305\u4e8e\u8fd1\u671f\u52a0\u5165CRAN\uff0c\u610f\u5473\u7740\u54b1\u53ef\u4ee5\u4f7f\u7528install\u3002Packages\u5b89\u88c5gwasrapidd\u5305\u4e86\u3002<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">install.packages(<span class=\"code-snippet__string\">\"gwasrapidd\"<\/span>) <span class=\"code-snippet__comment\">#\u5b89\u88c5gwasrapidd\u5305<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">library(gwasrapidd) <span class=\"code-snippet__comment\">#\u5f15\u7528gwasrapidd\u5305<\/span><\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u9996\u5148\u662fget_studies()\u51fd\u6570\uff0cget_studies()\u51fd\u6570\u6709\u4ee5\u4e0b\u53c2\u6570\u53ef\u9009\uff0c\u54b1\u4eec\u8fd9\u91cc\u5c31\u4ee5\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e3a\u4f8b\u7ed9\u5927\u5bb6\u6f14\u793a\u4e00\u4e0b\u3002<\/p>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.572202166064982\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_YbGPQfLqIuZUmiaQjO99ic5ul1gKzw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXEe3iaxofhb7z6dUQeP1TETCYib3hnRic6Bg1eulrAPR2zL3slMYbGPQfLqIuZUmiaQjO99ic5ul1gKzw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"554\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">\u901a\u8fc7efo_trait\u53c2\u6570\u6307\u5b9a\u67e5\u8be2\u6709\u5173\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u6587\u7ae0<\/span><\/code><code><span class=\"code-snippet_outer\">my_studies <- get_studies(efo_trait = <span class=\"code-snippet__string\">'autoimmune disease'<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">n(my_studies)<span class=\"code-snippet__comment\">#\u67e5\u770b\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u53d1\u6587\u91cf<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">my_studies@studies$study_id<span class=\"code-snippet__comment\">#\u83b7\u53d6\u6587\u7ae0\u7684id<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">my_studies@publications$title<span class=\"code-snippet__comment\">#\u67e5\u8be2\u6587\u7ae0\u9898\u76ee<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">open_in_pubmed(my_studies@publications$pubmed_id)<span class=\"code-snippet__comment\">#\u5728\u6d4f\u89c8\u5668\u4e2d\u5feb\u901f\u6253\u5f00pubmed\u754c\u9762<\/span><\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.48185483870967744\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_QEt96f2CmlJCm75atmKKUrbtb19IkQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXEe3iaxofhb7z6dUQeP1TETwOvfibXKbg0WXXM9w5mSm6aMFQEt96f2CmlJCm75atmKKUrbtb19IkQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"496\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u63a5\u4e0b\u6765\u662fget_associations()\u51fd\u6570\uff0c<br \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">my_associations<-get_associations(study_id=my_studies@studies$study_id)<\/span><\/code><code><span class=\"code-snippet_outer\">slotNames(my_associations)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.12454873646209386\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_dicetibr5hZ7dzNHUibG0VzW8r4JQw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXEe3iaxofhb7z6dUQeP1TETnN6YtFrKsPgj9DFnQgoOSlGEv8Wdicetibr5hZ7dzNHUibG0VzW8r4JQw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"554\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">get_associations()\u51fd\u6570\u4f1a\u8fd4\u56de6\u4e2aslot\uff0c\u5206\u522b\u4e3a\u5173\u8054\u503c\u5927\u5c0f\uff0c\u4f4d\u70b9\u4fe1\u606f\uff0c\u98ce\u9669\u7b49\u4f4d\u57fa\u56e0\u4fe1\u606f\uff0c\u57fa\u56e0\u4fe1\u606f\uff0c\u57fa\u56e0\u7684ENSEMBL\u7f16\u7801\u548c\u57fa\u56e0\u7684ENTREZ\u7f16\u7801\u4fe1\u606f\uff0c\u54b1\u5148\u628aP\u503c\u5c0f\u4e8ee-6\u7684\u4f4d\u70b9\u63d0\u53d6\u51fa\u6765<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">dplyr::filter(my_associations@associations, pvalue <<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__number\">1e-6<\/span>) %>%tidyr::drop_na(pvalue) %>% dplyr::pull(association_id) -><\/span><\/code><code><span class=\"code-snippet_outer\">association_ids<\/span><\/code><code><span class=\"code-snippet_outer\">my_associations2 <- my_associations[association_ids]<\/span><\/code><code><span class=\"code-snippet_outer\">n(my_associations2)<span class=\"code-snippet__comment\">#\u67e5\u770b\u663e\u8457SNP\u7684\u4e2a\u6570<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">my_associations2@risk_alleles[<span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">'variant_id'<\/span>, <span class=\"code-snippet__string\">'risk_allele'<\/span>, <span class=\"code-snippet__string\">'risk_frequency'<\/span>)] %>%print(n = <span class=\"code-snippet__literal\">Inf<\/span>)<span class=\"code-snippet__comment\">#\u663e\u793a\u663e\u8457\u4fe1\u53f7\u4f4d\u70b9\u7684RS ID\uff0c risk allele, <\/span><\/span><\/code><code><span class=\"code-snippet_outer\">\u9891\u7387<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.37184115523465705\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_zjQEejYj05Ey2HPKc9gibdNlkoprJg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXEe3iaxofhb7z6dUQeP1TET3SIIGPSmfLjn8KibC7dbStOH91zjQEejYj05Ey2HPKc9gibdNlkoprJg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"554\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u63a5\u4e0b\u6765\u54b1\u4f7f\u7528get_studies()\u83b7\u53d6\u542b\u6709\u7279\u5b9a\u4f4d\u70b9\u7684\u6587\u732e\uff0c\u54b1\u5c31\u6311rs11580078\u6765\u7ec3\u7ec3\u624b<br \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">s2 <- get_studies(variant_id = <span class=\"code-snippet__string\">'rs11580078'<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">s2@publications$title<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.14620938628158844\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_CfrXr6vYUP7JJvM5u3BZ0CUCfDas5g.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXEe3iaxofhb7z6dUQeP1TETQ5tk3rhIvqmvNl8ibpgHgWPcWCfrXr6vYUP7JJvM5u3BZ0CUCfDas5g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"554\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u597d\u5566\uff0cgwasrapidd\u5305\u6559\u7a0b\u5c31\u5230\u8fd9\u91cc\u5427\uff0c\u76f8\u4fe1\u901a\u8fc7\u4e0a\u9762\u7684\u6559\u7a0b\u5927\u5bb6\u53ef\u4ee5\u53d1\u73b0\uff0cgwasrapidd\u5305\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u5feb\u901f\u67e5\u8be2GWAS Catalog\u6570\u636e\u5e93\u4e2d\u60f3\u8981\u7684\u6570\u636e\u4fe1\u606f\uff0c\u867d\u7136\u201cgwasrapidd\u201d\u5305\u5728Github\u4e0a\u5df2\u5b58\u5728\u597d\u51e0\u5e74\u4e86\uff0c\u4f46\u76f4\u5230\u6700\u8fd1\u624d\u52a0\u5165\u5230CRAN\u91cc\uff0c\u76ee\u524d\u6765\u770b\uff0c\u8be5\u5305\u8fd8\u662f\u6bd4\u8f83\u7a33\u5b9a\u548c\u53ef\u9760\u7684\uff0c\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u8d76\u5feb\u5b66\u8d77\u6765\u5427\uff01<\/p>\n<section style=\"font-size: 16px;\">\n<section powered-by=\"xiumi.us\" style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;\">\n<section style=\"display: 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onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/RpJ9AibwAxrHda7noEqDcniacdL1ZtgwuZceOSlFQGLmVsUCMtCaEdjYDkEiakicI8ibmMicsbTqIib079asIZ4uKuS6Q\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"541\" style=\"letter-spacing: 0.034em;vertical-align: inherit;width: 135.75px;\" data-recalc-dims=\"1\" \/><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;min-width: 5%;height: auto;\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\">\n<section style=\"padding-right: 10px;padding-left: 10px;display: inline-block;vertical-align: top;width: auto;align-self: flex-start;flex: 0 0 auto;min-width: 5%;box-shadow: none;background-color: rgb(255, 255, 255);\">\n<section 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{"id":57422,"date":"2024-06-16T19:17:38","date_gmt":"2024-06-16T11:17:38","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=57422"},"modified":"2024-06-16T19:17:38","modified_gmt":"2024-06-16T11:17:38","slug":"r%e5%8c%85gwasrapidd%ef%bc%9agwas-catalog%e6%95%b0%e6%8d%ae%e7%9a%84%e8%8e%b7%e5%8f%96","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=57422","title":{"rendered":"R\u5305\u201cgwasrapidd\u201d\uff1aGWAS Catalog\u6570\u636e\u7684\u83b7\u53d6"},"content":{"rendered":"

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0px 5px 3px;\">\n<section style=\"text-align: center;transform: translate3d(2px, 0px, 0px);margin-top: -14px;margin-bottom: -14px;\" powered-by=\"xiumi.us\">\n<p>{ \u70b9\u51fb\u84dd\u5b57\uff0c\u5173\u6ce8\u6211\u4eec }<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u5e38\u7528\u7684\u6570\u636e\u5e93\uff0c\u4e3b\u8981\u4e3aOpenGWAS\u3001GWAS Catalog\u548cPhenoscanner\u4e09\u4e2a\u3002\u4eca\u5929\uff0c\u5c0f\u5e08\u59b9\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e00\u4e0b\u83b7\u53d6GWAS Catalog\u6570\u636e\u5e93\u6570\u636e\u7684\u201cgwasrapidd\u201d\u5305\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">gwasrapidd\u5305\u4e8e\u8fd1\u671f\u52a0\u5165CRAN\uff0c\u610f\u5473\u7740\u54b1\u53ef\u4ee5\u4f7f\u7528install\u3002Packages\u5b89\u88c5gwasrapidd\u5305\u4e86\u3002<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">install.packages(<span class=\"code-snippet__string\">\"gwasrapidd\"<\/span>) <span class=\"code-snippet__comment\">#\u5b89\u88c5gwasrapidd\u5305<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">library(gwasrapidd) <span class=\"code-snippet__comment\">#\u5f15\u7528gwasrapidd\u5305<\/span><\/span><\/code><\/pre>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u9996\u5148\u662fget_studies()\u51fd\u6570\uff0cget_studies()\u51fd\u6570\u6709\u4ee5\u4e0b\u53c2\u6570\u53ef\u9009\uff0c\u54b1\u4eec\u8fd9\u91cc\u5c31\u4ee5\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e3a\u4f8b\u7ed9\u5927\u5bb6\u6f14\u793a\u4e00\u4e0b\u3002<\/p>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.572202166064982\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_YbGPQfLqIuZUmiaQjO99ic5ul1gKzw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXEe3iaxofhb7z6dUQeP1TETCYib3hnRic6Bg1eulrAPR2zL3slMYbGPQfLqIuZUmiaQjO99ic5ul1gKzw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"554\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">\u901a\u8fc7efo_trait\u53c2\u6570\u6307\u5b9a\u67e5\u8be2\u6709\u5173\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u6587\u7ae0<\/span><\/code><code><span class=\"code-snippet_outer\">my_studies <- get_studies(efo_trait = <span class=\"code-snippet__string\">'autoimmune disease'<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">n(my_studies)<span class=\"code-snippet__comment\">#\u67e5\u770b\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u53d1\u6587\u91cf<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">my_studies@studies$study_id<span class=\"code-snippet__comment\">#\u83b7\u53d6\u6587\u7ae0\u7684id<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">my_studies@publications$title<span class=\"code-snippet__comment\">#\u67e5\u8be2\u6587\u7ae0\u9898\u76ee<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">open_in_pubmed(my_studies@publications$pubmed_id)<span class=\"code-snippet__comment\">#\u5728\u6d4f\u89c8\u5668\u4e2d\u5feb\u901f\u6253\u5f00pubmed\u754c\u9762<\/span><\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.48185483870967744\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_QEt96f2CmlJCm75atmKKUrbtb19IkQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXEe3iaxofhb7z6dUQeP1TETwOvfibXKbg0WXXM9w5mSm6aMFQEt96f2CmlJCm75atmKKUrbtb19IkQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"496\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u63a5\u4e0b\u6765\u662fget_associations()\u51fd\u6570\uff0c<br \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">my_associations<-get_associations(study_id=my_studies@studies$study_id)<\/span><\/code><code><span class=\"code-snippet_outer\">slotNames(my_associations)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.12454873646209386\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_dicetibr5hZ7dzNHUibG0VzW8r4JQw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXEe3iaxofhb7z6dUQeP1TETnN6YtFrKsPgj9DFnQgoOSlGEv8Wdicetibr5hZ7dzNHUibG0VzW8r4JQw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"554\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">get_associations()\u51fd\u6570\u4f1a\u8fd4\u56de6\u4e2aslot\uff0c\u5206\u522b\u4e3a\u5173\u8054\u503c\u5927\u5c0f\uff0c\u4f4d\u70b9\u4fe1\u606f\uff0c\u98ce\u9669\u7b49\u4f4d\u57fa\u56e0\u4fe1\u606f\uff0c\u57fa\u56e0\u4fe1\u606f\uff0c\u57fa\u56e0\u7684ENSEMBL\u7f16\u7801\u548c\u57fa\u56e0\u7684ENTREZ\u7f16\u7801\u4fe1\u606f\uff0c\u54b1\u5148\u628aP\u503c\u5c0f\u4e8ee-6\u7684\u4f4d\u70b9\u63d0\u53d6\u51fa\u6765<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">dplyr::filter(my_associations@associations, pvalue <<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__number\">1e-6<\/span>) %>%tidyr::drop_na(pvalue) %>% dplyr::pull(association_id) -><\/span><\/code><code><span class=\"code-snippet_outer\">association_ids<\/span><\/code><code><span class=\"code-snippet_outer\">my_associations2 <- my_associations[association_ids]<\/span><\/code><code><span class=\"code-snippet_outer\">n(my_associations2)<span class=\"code-snippet__comment\">#\u67e5\u770b\u663e\u8457SNP\u7684\u4e2a\u6570<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">my_associations2@risk_alleles[<span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">'variant_id'<\/span>, <span class=\"code-snippet__string\">'risk_allele'<\/span>, <span class=\"code-snippet__string\">'risk_frequency'<\/span>)] %>%print(n = <span class=\"code-snippet__literal\">Inf<\/span>)<span class=\"code-snippet__comment\">#\u663e\u793a\u663e\u8457\u4fe1\u53f7\u4f4d\u70b9\u7684RS ID\uff0c risk allele, <\/span><\/span><\/code><code><span class=\"code-snippet_outer\">\u9891\u7387<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.37184115523465705\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_zjQEejYj05Ey2HPKc9gibdNlkoprJg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXEe3iaxofhb7z6dUQeP1TET3SIIGPSmfLjn8KibC7dbStOH91zjQEejYj05Ey2HPKc9gibdNlkoprJg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"554\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u63a5\u4e0b\u6765\u54b1\u4f7f\u7528get_studies()\u83b7\u53d6\u542b\u6709\u7279\u5b9a\u4f4d\u70b9\u7684\u6587\u732e\uff0c\u54b1\u5c31\u6311rs11580078\u6765\u7ec3\u7ec3\u624b<br \/><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">s2 <- get_studies(variant_id = <span class=\"code-snippet__string\">'rs11580078'<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">s2@publications$title<\/span><\/code><\/pre>\n<\/section>\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.14620938628158844\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_CfrXr6vYUP7JJvM5u3BZ0CUCfDas5g.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEXEe3iaxofhb7z6dUQeP1TETQ5tk3rhIvqmvNl8ibpgHgWPcWCfrXr6vYUP7JJvM5u3BZ0CUCfDas5g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"554\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u597d\u5566\uff0cgwasrapidd\u5305\u6559\u7a0b\u5c31\u5230\u8fd9\u91cc\u5427\uff0c\u76f8\u4fe1\u901a\u8fc7\u4e0a\u9762\u7684\u6559\u7a0b\u5927\u5bb6\u53ef\u4ee5\u53d1\u73b0\uff0cgwasrapidd\u5305\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u5feb\u901f\u67e5\u8be2GWAS Catalog\u6570\u636e\u5e93\u4e2d\u60f3\u8981\u7684\u6570\u636e\u4fe1\u606f\uff0c\u867d\u7136\u201cgwasrapidd\u201d\u5305\u5728Github\u4e0a\u5df2\u5b58\u5728\u597d\u51e0\u5e74\u4e86\uff0c\u4f46\u76f4\u5230\u6700\u8fd1\u624d\u52a0\u5165\u5230CRAN\u91cc\uff0c\u76ee\u524d\u6765\u770b\uff0c\u8be5\u5305\u8fd8\u662f\u6bd4\u8f83\u7a33\u5b9a\u548c\u53ef\u9760\u7684\uff0c\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u8d76\u5feb\u5b66\u8d77\u6765\u5427\uff01<\/p>\n<section style=\"font-size: 16px;\">\n<section powered-by=\"xiumi.us\" style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 192.641px;align-self: center;flex: 0 0 auto;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 0.5em;margin-bottom: 0.5em;\">\n<section style=\"border-top: 1px dashed rgb(249, 172, 172);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"margin-right: 20px;margin-left: 20px;display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: -3px;\">\n<section style=\"text-align: justify;color: rgb(246, 207, 63);font-size: 20px;\">\n<p style=\"text-align: center;white-space: normal;\">\u2605<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 192.656px;align-self: center;flex: 0 0 auto;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 0.5em;margin-bottom: 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