{"id":57430,"date":"2024-06-16T19:18:37","date_gmt":"2024-06-16T11:18:37","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=57430"},"modified":"2024-06-16T19:18:37","modified_gmt":"2024-06-16T11:18:37","slug":"%e4%b9%b3%e9%85%b8%e5%8c%96%e4%bf%ae%e9%a5%b0%e5%a6%82%e6%ad%a4%e7%ae%80%e5%8d%95%ef%bc%9f%e5%a4%8d%e6%97%a6%e5%a4%a7%e5%ad%a6%e9%99%84%e5%b1%9e%e8%82%bf%e7%98%a4%e5%8c%bb%e9%99%a2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=57430","title":{"rendered":"\u201c\u4e73\u9178\u5316\u4fee\u9970\u201d\u5982\u6b64\u7b80\u5355\uff1f\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u674e\u5927\u536b\u56e2\u961f\u4ece\u591a\u7ef4\u89d2\u5ea6\u5efa\u7acb\u80bf\u7624\u9884\u540e\u6a21\u578b\u53d17\u5206+\uff01"},"content":{"rendered":"


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24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u4e2d\u8fdb\u884c\u9a8c\u8bc1\u3002\u591a\u7ef4\u89d2\u5ea6\u6253\u9020\u4e86\u4e00\u7bc7\u9884\u540e\u6587~\u91cc\u9762\u7684\u751f\u4fe1\u5206\u6790\u624b\u6bb5\u503c\u5f97\u5b66\u4e60\uff0c\u5fc3\u52a8\u4e0d\u5982\u884c\u52a8\u8d77\u6765\u5427\uff01<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(255, 0, 0);font-weight: bold;\">\uff08ps\uff1a\u5173\u6ce8\u9986\u957f\uff0c\u6211\u6709\u5f88\u591a\u751f\u4fe1\u70ed\u70b9\u548c\u601d\u8def\u5e2e\u4f60\u5feb\u901f\u4e0a\u5206 ~\uff09<\/span><span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018544\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-53.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 193px;height: 193px;\" data-recalc-dims=\"1\" \/><\/p>\n<section style=\"margin-left: 0pt;outline: 0px;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;text-indent: 0em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(255, 0, 0);font-weight: bold;\"><\/span><\/section>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018553\" data-ratio=\"0.4948064211520302\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_jyiaLsMkDhsMM90zj5MvMHn6CZRS5g.png?resize=553%2C274\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6YwHtcjt99MQrrN4ia8JdBMuWJOicQZzHNFnic8OvuzHzYibd9TjyiaLsMkDhsMM90zj5MvMHn6CZRS5g\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"1059\" height=\"274 .0\" style=\"outline: 0px;visibility: visible !important;width: 553.734px !important;\" width=\"553 .739990234375\" data-recalc-dims=\"1\"><\/span><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 21pt;outline: 0px;font-size: 12pt;font-family: "Times New Roman";text-indent: -21pt;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: Wingdings;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(237, 125, 49);\">l<span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-stretch: normal;font-size: 7pt;line-height: normal;font-family: "Times New Roman";\"><\/span><\/span><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u9898\u76ee\uff1a\u4e00\u4e2a\u591a\u7ef4\u7684\u65b9\u6cd5\u9610\u660e\u4e73\u9178\u5316\u76f8\u5173\u7684\u6807\u5fd7\u7269\u7684\u590d\u6742\u6027\u5728\u7ed3\u80a0\u76f4\u80a0\u764c\u7684\u9884\u540e\u548c\u6cbb\u7597\u89c1\u89e3<\/span>    <o:page style=\"outline: 0px;\"><\/o:page><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 21pt;outline: 0px;font-size: 12pt;font-family: "Times New Roman";text-indent: -21pt;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: Wingdings;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(237, 125, 49);\">l<span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-stretch: normal;font-size: 7pt;line-height: normal;font-family: "Times New Roman";\"><\/span><\/span><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u6742\u5fd7\uff1aJournal of Translational Medicine<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 21pt;outline: 0px;font-size: 12pt;font-family: "Times New Roman";text-indent: -21pt;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: Wingdings;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(237, 125, 49);\">l<span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-stretch: normal;font-size: 7pt;line-height: normal;font-family: "Times New Roman";\"><\/span><\/span><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=7.4<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 21pt;outline: 0px;font-size: 12pt;font-family: "Times New Roman";text-indent: -21pt;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: Wingdings;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(237, 125, 49);\">l<span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-stretch: normal;font-size: 7pt;line-height: normal;font-family: "Times New Roman";\"><\/span><\/span><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e742\u6708<\/span><\/section>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;color: rgb(0, 82, 255);\">\u7814\u7a76\u80cc\u666f<\/span><\/section>\n<p style=\"margin-top: 7.8pt;margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(0, 0, 0);\"><span style=\"outline: 0px;\">\u7ed3\u76f4\u80a0\u764c\uff08<\/span><span class=\"wx_search_keyword_wrap\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;\">CRC<\/span><span style=\"outline: 0px;\">\uff09\u662f\u4e16\u754c\u4e0a\u6700\u5e38\u89c1\u7684\u8bca\u65ad\u764c\u75c7\u4e4b\u4e00\uff0c\u65e9\u671f\u8bca\u65ad\u548c\u7cbe\u786e\u6cbb\u7597\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u60a3\u8005\u751f\u5b58\u7387\u3002\u6b64\u5916\uff0c\u5e38\u7528\u7684\u7ed3\u76f4\u80a0\u764c\u6cbb\u7597\u836f\u7269\u5728\u5316\u7597\u521d\u671f\u8868\u73b0\u51fa\u7597\u6548\u3002\u4e73\u9178\u5316\u662f\u7ffb\u8bd1\u540e\u4fee\u9970\uff08PTMs\uff09\u9886\u57df\u7684\u65b0\u8d21\u732e\u8005\uff0c\u7ed3\u76f4\u80a0\u764c\u7ec6\u80de\u901a\u5e38\u8868\u73b0\u51fa\u4ee3\u8c22\u7279\u5f81\uff0c\u5305\u62ec\u4e73\u9178\u79ef\u7d2f\uff0c\u5f71\u54cd\u80bf\u7624\u7684\u8d77\u59cb\u3001\u53d1\u80b2\u548c\u514d\u75ab\u73af\u5883\u3002\u4e73\u9170\u5316\u5728\u5404\u79cd\u80bf\u7624\u4e2d\u8868\u73b0\u51fa\u5931\u8c03\u3002\u7136\u800c\uff0c\u5b83\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u590d\u6742\u53c2\u4e0e\uff0c\u7279\u522b\u662f\u975e\u7ec4\u86cb\u767d\u4e73\u9170\u5316\u53ca\u5176\u4e0e\u4ee3\u8c22\u548c\u514d\u75ab\u9003\u907f\u7684\u4ea4\u53c9\uff0c\u4ecd\u7136\u662f\u4e2a\u8c1c\u3002<\/span><\/span><\/p>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;color: rgb(0, 82, 255);\">\u6570\u636e\u6765\u6e90<\/span><\/section>\n<table cellspacing=\"0\" cellpadding=\"0\" width=\"677\">\n<tbody style=\"outline: 0px;\">\n<tr style=\"outline: 0px;\">\n<td width=\"76\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-top-width: 1pt;border-top-color: rgb(91, 155, 213);border-right: none;border-bottom-width: 1pt;border-bottom-color: rgb(91, 155, 213);border-left-width: 1pt;border-left-color: rgb(91, 155, 213);background: rgb(91, 155, 213);\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">\u6570\u636e\u96c6\/\u961f\u5217<\/span><span style=\"outline: 0px;font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-top-width: 1pt;border-top-color: rgb(91, 155, 213);border-right: none;border-bottom-width: 1pt;border-bottom-color: rgb(91, 155, 213);border-left-width: 1pt;border-left-color: rgb(156, 194, 229);background: rgb(91, 155, 213);\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">\u6570\u636e\u5e93<\/span><span style=\"outline: 0px;font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\"><\/span><\/section>\n<\/td>\n<td width=\"99\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-top-width: 1pt;border-top-color: rgb(91, 155, 213);border-right: none;border-bottom-width: 1pt;border-bottom-color: rgb(91, 155, 213);border-left-width: 1pt;border-left-color: rgb(156, 194, 229);background: rgb(91, 155, 213);\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">\u6570\u636e\u7c7b\u578b<\/span><span style=\"outline: 0px;font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\"><\/span><\/section>\n<\/td>\n<td width=\"179\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(91, 155, 213) rgb(91, 155, 213) rgb(91, 155, 213) rgb(156, 194, 229);background: rgb(91, 155, 213);\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">\u8be6\u7ec6\u4fe1\u606f<\/span><span style=\"outline: 0px;font-size: 11pt;font-family: "Microsoft YaHei UI";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\"><\/span><\/section>\n<\/td>\n<\/tr>\n<tr style=\"outline: 0px;height: 27.95pt;\">\n<td width=\"76\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\" height=\"27\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">GSE132257<\/span><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\"><\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\" height=\"27\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"99\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\" height=\"27\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">RNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"179\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\" height=\"27\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">10\u4e2aCRC\u6837\u672c<\/span><\/section>\n<\/td>\n<\/tr>\n<tr style=\"outline: 0px;height: 27.95pt;\">\n<td width=\"76\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\" height=\"27\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">GSE39582<\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\" height=\"27\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"99\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\" height=\"27\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">RNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"179\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\" height=\"27\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">579\u4f8b\u75c5\u4eba<\/span><\/section>\n<\/td>\n<\/tr>\n<tr style=\"outline: 0px;height: 27.95pt;\">\n<td width=\"76\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\" height=\"27\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">GSE17536<\/span><\/section>\n<\/td>\n<td width=\"70\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\" height=\"27\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"99\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\" height=\"27\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">RNA-seq\u6570\u636e<\/span><\/section>\n<\/td>\n<td width=\"179\" valign=\"middle\" style=\"padding: 0pt 5.4pt;outline: 0px;word-break: break-all;hyphens: auto;border-width: 1pt;border-color: rgb(156, 194, 229);background: rgb(222, 234, 246);\" height=\"27\">\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(51, 51, 51);letter-spacing: 0.4pt;\">177\u4f8b\u75c5\u4eba<\/span><\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<section style=\"margin-bottom: 0px;outline: 0px;\"><br style=\"outline: 0px;\" \/><\/section>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;color: rgb(0, 82, 255);\">\u7814\u7a76\u601d\u8def<\/span><\/section>\n<section style=\"margin-left: 0pt;outline: 0px;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;text-indent: 0em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u5229\u7528\u7ec4\u7ec7\u5fae\u9635\u5217\u4e0a\u7684<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u5206\u6790<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u4ee5\u53ca\u7ed3\u76f4\u80a0\u7ec6\u80de\u7cfb\u7684\u4e34\u5e8a\u4fe1\u606f\u548c\u514d\u75ab\u8367\u5149\uff0c\u7814\u7a76\u6574\u4f53\u4e73\u9170\u5316\u7684\u5b58\u5728\u53ca\u5176\u4e0e\u7ed3\u76f4\u80a0\u764c\u53d1\u751f\u548c\u8fdb\u5c55\u7684\u5173\u7cfb\u53ca\u5176\u529f\u80fd\u5b9a\u4f4d\u3002\u5229\u7528<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">AUCell<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u7b97\u6cd5\u4ee5\u53ca<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">\u5355\u7ec6\u80deRNA\u6d4b\u5e8f<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u6570\u636e\u4e2d\u7684\u76f8\u5173\u6027\u5206\u6790\uff0c\u4ee5\u53caTCGA\u6570\u636e\u96c6\u4e2d\u7684<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">Cox<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u56de\u5f52\u548c<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\">Lasso<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u56de\u5f52\u5206\u6790\u5e76\u5728GEO\u6570\u636e\u96c6\u4e2d\u5f97\u5230\u8bc1\u5b9e\uff0c\u786e\u5b9a\u4e86\u9884\u6d4b\u7ed3\u76f4\u80a0\u764c\u9884\u540e\u7684\u57fa\u56e0\u7279\u5f81\u3002\u968f\u540e\uff0c\u5206\u6790\u4e73\u9170\u5316\u76f8\u5173\u57fa\u56e0\u98ce\u9669\u4e0e\u4e34\u5e8a\u7279\u5f81\u3001\u7a81\u53d8\u60c5\u51b5\u3001\u751f\u7269\u5b66\u529f\u80fd\u3001\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u3001\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u548c\u836f\u7269\u654f\u611f\u6027\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/section>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018551\" data-ratio=\"1.8018018018018018\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_akIglF56d3uycCz508jQxqqGKy2RQg.png?resize=444%2C800\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6YwHtcjt99MQrrN4ia8JdBMhgiaM01wET2gLKyyFlkwkpp0QiakIglF56d3uycCz508jQxqqGKy2RQg\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"444\" height=\"800 .1199951171875\" style=\"outline: 0px;visibility: visible !important;width: 444.062px !important;\" width=\"444 .07000732421875\" data-recalc-dims=\"1\"><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span>    <o:page style=\"outline: 0px;\"><\/o:page><\/section>\n<section style=\"margin-top: 24px;margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;color: rgb(0, 82, 255);\">\u4e3b\u8981\u7ed3\u679c<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(255, 0, 0);font-weight: bold;background: rgb(255, 255, 0);\"><\/span><\/section>\n<p style=\"margin-top: 0pt;margin-bottom: 16px;margin-left: 18pt;outline: 0px;text-indent: -18pt;font-size: 12pt;font-family: "Times New Roman";line-height: 1.75em;\"><strong style=\"outline: 0px;\"><span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">1.<span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-weight: normal;font-stretch: normal;font-size: 7pt;line-height: normal;\"><\/span><\/span><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\uff0c\u6574\u4f53\u4e73\u9178\u5316\u6c34\u5e73\u4e0a\u8c03\u5e76\u4e0e\u80bf\u7624\u8fdb\u5c55\u76f8\u5173<\/span><\/strong><\/p>\n<section style=\"margin-left: 0pt;outline: 0px;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;text-indent: 0em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u9996\u5148\uff0c\u5bf9CRC\u6837\u672c\u8fdb\u884c\u4e86\u9a8c\u8bc1\uff0c\u53d1\u73b0\u4e0e\u90bb\u8fd1\u7684\u6b63\u5e38\u7ec4\u7ec7\u76f8\u6bd4\uff0c\u764c\u53d8\u7ec4\u7ec7\u4e2d\u7684\u6574\u4f53\u4e73\u9178\u5316\u6c34\u5e73\u5347\u9ad8\uff08\u56fe1A\uff09\u3002\u4e0e\u6b63\u5e38\u7ed3\u80a0\u4e0a\u76ae\u7ec6\u80de\u7cfbNCM46\u76f8\u6bd4\uff0cCRC\u7ec6\u80de\u7cfb\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u8be5\u89c2\u5bdf\u7ed3\u679c\uff08\u56fe1B\uff09\u3002\u6b64\u5916\uff0c\u5229\u7528\u514d\u75ab\u8367\u5149\u6765\u8bc4\u4f30CRC\u7ec6\u80de\u7cfb\u7684\u7efc\u5408\u4e73\u9178\u5316\u72b6\u6001\u3002\u7ed3\u679c\u8868\u660e\uff0c\u8d56\u6c28\u9178\u4e73\u9178\u5316\u5e76\u4e0d\u96c6\u4e2d\u5728\u7ec6\u80de\u6838\u4e2d\uff0c\u4f46\u4e5f\u5b58\u5728\u4e8e\u7ec6\u80de\u8d28\u4e2d\uff0c\u5728\u591a\u79cd\u86cb\u767d\u8d28\u4fee\u9970\u4e2d\u7684\u6d41\u884c\u3002\u5bf9\u4e00\u4e2a\u7efc\u5408\u7684\u7ec4\u7ec7\u82af\u7247\u8fdb\u884c\u4e86\u514d\u75ab\u7ec4\u5316\u67d3\u8272\uff0cCRC\u7ec4\u7ec7\u4e2d\u5168\u7403\u4e73\u5316\u6c34\u5e73\u8f83\u6b63\u5e38\u7ec4\u7ec7\u5927\u5e45\u589e\u52a0\uff08\u56fe1C\uff09\uff0c\u5e76\u4e14\u4e73\u5316\u6c34\u5e73\u968f\u7740\u9636\u6bb5\u7684\u589e\u52a0\u800c\u4e0a\u5347\uff08\u56fe1D\uff09\u3002\u6b64\u5916\uff0c\u65e0\u8bba\u662f\u5728\u65e9\u671f\uff08I-III\u671f\uff09\u548c\u665a\u671f\uff08II\u671f\uff09\u60a3\u8005\u4e2d\uff0c\u8f83\u9ad8\u7684\u6574\u4f53\u4e73\u9178\u5316\u6c34\u5e73\u4e0e\u4e0d\u826f\u9884\u540e\u76f8\u5173\uff08\u56fe1E\uff0cF\uff09\u3002\u901a\u8fc7\u5355\u56e0\u7d20\u548c\u591a\u56e0\u7d20Cox\u56de\u5f52\u5206\u6790\uff0c\u4e73\u9178\u5316\u6c34\u4e3a\u7ed3\u76f4\u80a0\u764c\u7684\u72ec\u7acb\u9884\u540e\u56e0\u7d20\uff08\u56fe1G\uff0cH\uff09\u3002\u9ad8\u4e73\u9178\u5316\u7ec4\u8868\u73b0\u51fa\u66f4\u9ad8\u7684\u590d\u53d1\u7387\u548c\u8fdc\u5904\u8f6c\u79fb\u7387\uff0c\u4ee5\u53ca\u66f4\u665a\u671f\u7684\u80bf\u7624\u5206\u671f\uff08\u56fe1I-K\uff09\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u5f3a\u8c03\u4e86\u4e73\u9178\u5316\u4f5c\u4e3a\u7ed3\u76f4\u80a0\u764c\u9884\u540e\u6807\u5fd7\u7269\u7684\u6f5c\u5728\u610f\u4e49\uff0c\u9610\u660e\u4e86\u5176\u4e0e\u75be\u75c5\u8fdb\u5c55\u548c\u9884\u540e\u7684\u76f8\u5173\u6027\u3002<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/section>\n<p style=\"margin-bottom: 8px;margin-left: 0pt;outline: 0px;text-align: center;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018554\" data-ratio=\"1.0433639947437583\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_W7VPtEHwb7czbRuchZ1vWtZibYNkxg.png?resize=553%2C577\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6YwHtcjt99MQrrN4ia8JdBMSjoDrfcrEYIAnSC1CMrHn9LZ2W7VPtEHwb7czbRuchZ1vWtZibYNkxg\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"761\" height=\"577 .739990234375\" style=\"outline: 0px;visibility: visible !important;width: 553.734px !important;\" width=\"553 .739990234375\" data-recalc-dims=\"1\"><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/p>\n<p style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u56fe1 \u603b\u4f53\u4e73\u9178\u5316\u6c34\u5e73\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u4e0a\u8c03\uff0c\u5e76\u4e0e\u80bf\u7624\u8fdb\u5c55\u76f8\u5173<\/span><\/p>\n<p style=\"margin-top: 0pt;margin-bottom: 16px;margin-left: 18pt;outline: 0px;text-indent: -18pt;font-size: 12pt;font-family: "Times New Roman";line-height: 1.75em;\"><strong style=\"outline: 0px;\"><span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">2.<span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-weight: normal;font-stretch: normal;font-size: 7pt;line-height: normal;\"><\/span><\/span><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u4ece\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u4e2d\u9274\u5b9a\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u4e73\u9178\u5316\u76f8\u5173\u57fa\u56e0\uff08<\/span><span style=\"outline: 0px;\"><span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">LRGs<\/span><\/span><span style=\"outline: 0px;\"><\/span><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\uff09<\/span><\/strong><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/p>\n<section style=\"margin-left: 0pt;outline: 0px;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;text-indent: 0em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u5bf9\u5355\u7ec6\u80de\u6d4b\u5e8f\u6570\u636e\u8fdb\u884c\u4e86\u6df1\u5165\u5206\u6790\uff0c\u5c06\u6240\u6709\u7ec6\u80de\u805a\u4e3a22\u4e2a\u4e0d\u540c\u7684\u7ec4\uff0c\u5982\u56fe2A\u6240\u793a\u300211\u4e2a\u7279\u5b9a\u7ec6\u80de\u7c07\u7684\u5206\u5e03\u5982\u56fe2B\u6240\u793a\u3002\u6839\u636e\u4e2d\u4f4dAUC\u8bc4\u5206\uff0c\u5bf9\u6240\u6709\u7ec6\u80de\u8fdb\u884cLRGs\u7684AUC\u8bc4\u5206\uff0c\u5e76\u5c06\u5176\u5206\u4e3a\u9ad8\u4e73\u5316AUC\u7ec4\u548c\u4f4e\u4e73\u5316AUC\u7ec4\uff08\u56fe2C\uff09\u3002\u5177\u6709\u5927\u91cf\u4e73\u9178\u76f8\u5173\u57fa\u56e0\uff08LRGs\uff09\u7684\u7ec6\u80de\u4e3b\u8981\u662f\u7ea2\u8272\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u5982NK\u7ec6\u80de\u3001T\u7ec6\u80de\u548cB\u7ec6\u80de\uff08\u56fe2D\uff09\u3002\u968f\u540e\uff0c\u5728\u9ad8\u4e73\u9178\u5316\u7ec4\u548c\u4f4e\u4e73\u9178\u5316\u7ec4\u4e4b\u95f4\u9274\u5b9a\u4e86879\u4e2a\u5dee\u5f02\u8868\u8fbe\u7684\u57fa\u56e0\uff08DEGs\uff09\u3002\u6b64\u5916\uff0c\u76f8\u5173\u5206\u6790\u663e\u793a\u4e86\u4e0e\u4e73\u5316\u6d3b\u6027\u6700\u5bc6\u5207\u76f8\u5173\u7684\u524d100\u4e2a\u9ad8\u5ea6\u4e73\u5316\u76f8\u5173\u7684\u57fa\u56e0\uff08CORGs\uff09\uff08\u56fe2E\uff09\u3002\u901a\u8fc7\u57fa\u56e0\u96c6\u53d8\u5f02\u5206\u6790\uff08GSVA\uff09\u3001\u57fa\u56e0\u672c\u4f53\uff08GO\uff09\u5206\u6790\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86LRGs\u76f8\u5173\u7684\u5206\u5b50\u7279\u5f81\u3002\u4e73\u9178\u5316\u5728\u201cMYC\u201d\u3001\u201cPI3K-AKT-mTOR\u201d\u3001\u201c\u7f3a\u6c27\u201d\u7b49\u4fc3\u80bf\u7624\u901a\u8def\u4e2d\u53d1\u6325\u4e86\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u5e76\u4e0e\u514d\u75ab\u76f8\u5173\u901a\u8def\u5982\u201cINTERFERON_GAMMA_RESPONSE\u201d\u3001\u201cIL2_STAT5_SIGNALING\u201d\u548c\u201cTGF_BETA_SIGNALING\u201d\u76f8\u5173\uff08\u56fe2F-H\uff09\u3002<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/section>\n<p style=\"margin-bottom: 8px;margin-left: 0pt;outline: 0px;text-align: center;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018552\" data-ratio=\"0.8813025210084033\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_fbAX9KOqOsicXVQnPgXf41ia08DzUA.png?resize=553%2C488\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6YwHtcjt99MQrrN4ia8JdBMtax3RRGr7dicBs3Tt7YPznpAXjPfbAX9KOqOsicXVQnPgXf41ia08DzUA\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"952\" height=\"488 .010009765625\" style=\"outline: 0px;visibility: visible !important;width: 553.734px !important;\" width=\"553 .739990234375\" data-recalc-dims=\"1\"><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/p>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u56fe2 \u4e0e\u80bf\u7624\u8fdb\u5c55\u76f8\u5173\u4ece\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u4e2d\u9274\u5b9aCRC\u4e2d\u4e73\u9178\u5316\u76f8\u5173\u57fa\u56e0(LRGs)<\/span><\/section>\n<p style=\"margin-top: 0pt;margin-bottom: 16px;margin-left: 18pt;outline: 0px;text-indent: -18pt;font-size: 12pt;font-family: "Times New Roman";line-height: 1.75em;\"><strong style=\"outline: 0px;\"><span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">3.<span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-kerning: auto;font-optical-sizing: auto;font-feature-settings: normal;font-variation-settings: normal;font-variant-position: normal;font-weight: normal;font-stretch: normal;font-size: 7pt;line-height: normal;\"><\/span><\/span><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u65b0\u578b\u7684LRG\u6807\u5fd7\u7269\u63ed\u793a\u4e86\u5bf9\u7ed3\u76f4\u80a0\u764c\u9884\u540e\u7684\u9884\u6d4b\u80fd\u529b<\/span><\/strong><span style=\"outline: 0px;font-family: \u5b8b\u4f53;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/p>\n<section style=\"margin-left: 0pt;outline: 0px;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;text-indent: 0em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u5206\u6790TCGA\u961f\u5217\u6765\u63d0\u53d6LRG\u9884\u540e\u7279\u5f81\u3002\u9996\u5148\uff0c\u901a\u8fc7\u5355\u53d8\u91cfCox\u56de\u5f52\u5206\u6790\u786e\u5b9a\u4e8667\u4e2a\u4e0eCRC\u76f8\u5173\u7684\u5019\u9009\u57fa\u56e0\uff0c\u5982\u70ed\u56fe\uff08\u56fe3A\uff09\u6240\u793a\u3002\u7136\u540e\u91c7\u7528Lasso\u5206\u6790\uff0c\u9274\u5b9a\u4e8623\u4e2a\u57fa\u56e0\uff08\u56fe3B\uff09\u3002\u8fd9\u4e9b\u57fa\u56e0\u7ec4\u6210\u4e00\u4e2aLRG\u8bc4\u5206\u7684\u9884\u6d4b\u6a21\u578b\uff08LRGS\uff09\uff08\u56fe3C\uff09\u3002\u6700\u521d\u768411\u4e2a\u57fa\u56e0\u4e0e\u9ad8\u98ce\u9669\u76f8\u5173\uff0c\u800c\u968f\u540e\u768412\u4e2a\u57fa\u56e0\u4e0e\u4f4e\u98ce\u9669\u76f8\u5173\u3002\u8be5\u7efc\u5408\u6a21\u578b\u6574\u5408\u4e86\u8fd9\u4e9b\u4e2a\u4f53\u57fa\u56e0\u7684\u9884\u6d4b\u80fd\u529b\uff0c\u4ee5\u4f5c\u4e3a\u8bc4\u4f30CRC\u9884\u540e\u7684\u53c2\u8003\u5de5\u5177\u3002<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/section>\n<section style=\"margin-left: 0pt;outline: 0px;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;text-indent: 0em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u6839\u636e\u4e2d\u4f4d\u98ce\u9669\u8bc4\u5206\u5c06\u60a3\u8005\u5206\u4e3a\u9ad8\u3001\u4f4e\u98ce\u9669\u7ec4\uff0c\u8bc4\u4f30LRG\u7279\u5f81\u7684\u9884\u540e\u4ef7\u503c\u3002Kaplan-Meier\u751f\u5b58\u671f\u5206\u6790\u663e\u793a\uff0c\u4e24\u7ec4\u6765\u81eaGSE39582\u548cGSE17536\u7684CRC\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff0c\u6b64\u5916\uff0cROC\u5206\u6790\u663e\u793a1-\u30012-\u30013-\u30014-\u548c5\u5e74\u5bf9TCGA\u8bad\u7ec3\u96c6\u3001GSE39582\u6d4b\u8bd5\u96c6\u548cGSE17536\u6d4b\u8bd5\u96c6\u5177\u6709\u8f83\u5f3a\u7684\u9884\u6d4b\u80fd\u529b\uff08\u56fe3D-F\uff09\u3002<\/span>   <o:page style=\"outline: 0px;\"><\/o:page><\/section>\n<p style=\"margin-bottom: 8px;margin-left: 0pt;outline: 0px;text-align: center;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018555\" data-ratio=\"1.152875175315568\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_ER9q29m46YY2FSllvkUg6o6kKiahog.png?resize=553%2C638\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6YwHtcjt99MQrrN4ia8JdBMoIebduP6jK3xBLNrFsfJSQufhER9q29m46YY2FSllvkUg6o6kKiahog\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"713\" height=\"638 .4100341796875\" style=\"outline: 0px;visibility: visible !important;width: 553.734px !important;\" width=\"553 .739990234375\" data-recalc-dims=\"1\"><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/p>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u56fe3 \u65b0\u578bLRG\u7279\u5f81\u63ed\u793a\u4e86\u5bf9\u7ed3\u76f4\u80a0\u764c\u9884\u540e\u7684\u5f3a\u5927\u9884\u6d4b\u80fd\u529b<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 16px;margin-left: 18pt;outline: 0px;text-indent: -18pt;font-size: 12pt;font-family: "Times New Roman";line-height: 1.75em;\"><strong style=\"outline: 0px;\">4.LRGS\u4e2d\u5173\u952e\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\u7684\u9a8c\u8bc1<\/strong><\/section>\n<section style=\"margin-left: 0pt;outline: 0px;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;text-indent: 0em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">scRNA-seq\u6570\u636e\u5206\u6790\u663e\u793a\uff0cHSPB1\u3001ACTG1\u3001SFPQ\u3001RBM3\u3001LY6E\u3001AP2M1\u3001RAB5C\u3001MED10\u3001RBM17\u3001METTL9\u3001LGALS4\u4e3b\u8981\u5728\u4e0a\u76ae\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u800cLEPROTL1\u3001TERF2IP\u5728T\u548cNK\u7ec6\u80de\u3001ARL4C\u3001ARPC1B\u3001SLC2A3\u3001H2AFY\u3001LITAF\u5728\u5355\u6838\u7ec6\u80de\u5de8\u566c\u7ec6\u80de\u4e2d\u8868\u8fbe\u7a81\u51fa\uff08\u56fe4A\uff09\u3002\u6b64\u5916\uff0cNR1H2\u3001PTTG1\u5728\u6240\u6709\u7ec6\u80de\u7c07\u4e2d\u5747\u68c0\u6d4b\u6c34\u5e73\u8f83\u4f4e\u3002KEGG\u5bcc\u96c6\u5206\u6790\u4e5f\u8868\u660e\uff0cLRGs\u4e0e\u541e\u566c\u5c0f\u4f53\u3001\u6297\u539f\u52a0\u5de5\u548c\u5448\u9012\u7b49\u6709\u5173\uff08\u56fe4B\uff09\u3002\u968f\u540e\uff0c\u5927\u91cfRNA\u8f6c\u5f55\u7ec4\u8fdb\u4e00\u6b65\u5206\u6790\u663e\u793a\uff0cLEPROTL1\u3001SLC2A3\u3001LY6E\u3001ARL4C\u3001AP2M1\u3001RAB5C\u3001LITAF\u4e0e\u514d\u75ab\u8bc4\u5206\u5448\u6b63\u76f8\u5173\uff0c\u800cLLC2A3\u3001LY6E\u6574\u4f53\u4e0e\u514d\u75ab\u7ec6\u80de\u81a8\u80c0\u5448\u8d1f\u76f8\u5173\uff0c LITAF\u3001ARL4C\u3001SLC2A3\u548cLEPROTL1\u4e0e\u51e0\u4e4e\u6240\u6709\u514d\u75ab\u7ec6\u80de\u663e\u8457\u76f8\u5173\u3002\u5bf9\u4e0d\u540c\u7ec6\u80de\u7cfb\u4e2d\u7279\u5f81\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\u8fdb\u884c\u4e86\u5168\u9762\u7684\u8bc4\u4f30\u3002\u4e0e\u6b63\u5e38\u7ec6\u80de\u7cfb\u76f8\u6bd4\uff0cCRC\u7ec6\u80de\u7cfb\u4e2dRBM17\u3001TERF2IP\u3001AP2M1\u3001NR1H2\u3001MED10\u3001HSPA1B\u3001ARL4C\u3001LY6E\u3001ARPC1B\u3001HSPB1\u7684RNA\u8868\u8fbe\u6c34\u5e73\u663e\u8457\u5347\u9ad8\uff08\u56fe4C\uff09\u3002\u6b64\u5916\uff0c\u4e3a\u4e86\u52a0\u5f3a\u8fd9\u4e9b\u57fa\u56e0\u8868\u8fbe\u6539\u53d8\u5728CRC\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86\u5b83\u4eec\u5728\u4e34\u5e8a\u7ec4\u7ec7\u4e2d\u7684\u6c34\u5e73\uff08\u56fe4D\uff09\u3002\u6b64\u5916\uff0c\u7814\u7a76\u6269\u5c55\u5230\u6838\u5fc3\u98ce\u9669\u57fa\u56e0\u7684\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\uff0c\u5305\u62ecAP2M1\u3001LY6E\u3001ARL4C\u3001ARPC1B\u548cTERF2IP\uff0c\u4e0eRNA\u6c34\u5e73\u4e00\u81f4(\u56fe4E-I)\u3002<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/section>\n<p style=\"margin-bottom: 8px;margin-left: 0pt;outline: 0px;text-align: center;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018559\" data-ratio=\"1.1654978962131837\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_okjs1DiaH9nTp9HYT2VRMURlG6Gd7g.png?resize=553%2C645\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6YwHtcjt99MQrrN4ia8JdBMYyqH3suiaSEggUonspKKad2vhXokjs1DiaH9nTp9HYT2VRMURlG6Gd7g\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"713\" height=\"645 .3399658203125\" style=\"outline: 0px;visibility: visible !important;width: 553.734px !important;\" width=\"553 .739990234375\" data-recalc-dims=\"1\"><\/span> <o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u56fe4 \u4ece\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u4e2d\u9274\u5b9aCRC\u4e2d\u4e73\u9178\u5316\u76f8\u5173\u57fa\u56e0(LRGs)<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 16px;margin-left: 18pt;outline: 0px;text-indent: -18pt;font-size: 12pt;font-family: "Times New Roman";line-height: 1.75em;\"><strong style=\"outline: 0px;\">5.\u4e0eLRG\u6807\u5fd7\u7269\u76f8\u5173\u7684\u751f\u7269\u5b66\u673a\u5236\u7684\u9884\u6d4b<\/strong><\/section>\n<section style=\"margin-left: 0pt;outline: 0px;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;text-indent: 0em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u6df1\u5165\u7814\u7a76\u4e86LRGS\u6a21\u578b\u5728TCGA\u961f\u5217\u4e2d\u7684\u57fa\u56e0\u7ec4\u5f02\u8d28\u6027\u3002\u6211\u4eec\u5bf9LRG\u7a81\u53d8\u57fa\u56e0\u7684\u7a81\u53d8\u666f\u89c2\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5e76\u4e0e\u9891\u7e41\u7a81\u53d8\u7684\u57fa\u56e0\u5982APC\u3001TP53\u3001TTN\u548cKRAS\u8fdb\u884c\u4e86\u76f8\u5173\u6027\u5206\u6790\uff08\u56fe5A, 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onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6YwHtcjt99MQrrN4ia8JdBMIpKNRrqU7jEichpGGHib7HLatkFZYBog4YZm6Xl4s5UYuX6MoUUcwtKA\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"685\" height=\"537 .030029296875\" style=\"outline: 0px;visibility: visible !important;width: 553.734px !important;\" width=\"553 .739990234375\" data-recalc-dims=\"1\"><\/span> <o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u56fe5 \u9884\u6d4b\u4e0eLRGs\u98ce\u9669\u76f8\u5173\u7684\u751f\u7269\u5b66\u673a\u5236<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 16px;margin-left: 18pt;outline: 0px;text-indent: -18pt;font-size: 12pt;font-family: 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0px;\">\u5206\u6790\u8868\u660e\u5728\u4f4e\u98ce\u9669\u7ec4\u4e2d\u5177\u6709\u5f3a\u5927\u7684\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff08\u56fe6C\uff09\u3002\u9ad8\u5371\u4eba\u7fa4\u7ec4\u4e2dPD-1\u548cPDCD1\u7b49\u514d\u75ab\u68c0\u67e5\u70b9\u57fa\u56e0\uff08ICCDs\uff09\u7684\u8868\u8fbe\u5347\u9ad8\uff0c\u63d0\u793a\u4e86\u6f5c\u5728\u7684\u6cbb\u7597\u9776\u70b9\uff08\u56fe6D\uff09\u3002\u901a\u8fc7\u591a\u91cd\u514d\u75ab\u7ec4\u5316\uff08mIHC\uff09\u9a8c\u8bc1\u4e86ARL4C\u3001ARPC1B\u548cTERF2IP\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u663e\u8457\u6027\uff0c\u5b83\u4eec\u7684\u8868\u8fbe\u4e0eCD8 T\u7ec6\u80de\u7684\u5b58\u5728\u5448\u8d1f\u76f8\u5173\uff08\u56fe6E\uff0cF\uff09\u3002<\/span><\/span><o:page style=\"outline: 0px;\"><\/o:page><\/p>\n<p style=\"margin-bottom: 8px;margin-left: 0pt;outline: 0px;text-align: center;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018558\" data-ratio=\"1.0392670157068062\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_m3QVgRB7c1GgId1XSHiaQ6BCiac8Ag.png?resize=553%2C575\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6YwHtcjt99MQrrN4ia8JdBMIbdjc8gWWGIoicUNW6HNY6FVjQ7m3QVgRB7c1GgId1XSHiaQ6BCiac8Ag\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"764\" height=\"575 .47998046875\" style=\"outline: 0px;visibility: visible !important;width: 553.734px !important;\" width=\"553 .739990234375\" data-recalc-dims=\"1\"><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: 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style=\"outline: 0px;\"><\/o:page><\/p>\n<p style=\"margin-top: 7.8pt;margin-bottom: 8px;margin-left: 0pt;outline: 0px;text-align: center;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018556\" data-ratio=\"0.7012369172216937\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_tP1iaDGtRnNkM9ZswT8AK2ClnvRMmQ.png?resize=553%2C388\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6YwHtcjt99MQrrN4ia8JdBMh3wV8QqcTLAsqa1KUKyBVB4v7tP1iaDGtRnNkM9ZswT8AK2ClnvRMmQ\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"1051\" height=\"388 .2699890136719\" style=\"outline: 0px;visibility: visible !important;width: 553.734px !important;\" width=\"553 .739990234375\" data-recalc-dims=\"1\"><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/p>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u56fe7 LRG\u6807\u5fd7\u7269\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u9884\u6d4b\u4ef7\u503c<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 16px;margin-left: 18pt;outline: 0px;text-indent: -18pt;font-size: 12pt;font-family: "Times New Roman";line-height: 1.75em;\"><strong style=\"outline: 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style=\"outline: 0px;\"><\/o:page><\/section>\n<p style=\"margin-bottom: 8px;margin-left: 0pt;outline: 0px;text-align: center;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018561\" data-ratio=\"0.7101449275362319\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_JBUHmlTLBSIiakZHkUIkeZtMNdWbRQ.png?resize=553%2C393\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6YwHtcjt99MQrrN4ia8JdBMKzqujLu3wZG5J4Z0XoyVqdYXlJBUHmlTLBSIiakZHkUIkeZtMNdWbRQ\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"1035\" height=\"393 .2099609375\" style=\"outline: 0px;visibility: visible !important;width: 553.734px !important;\" width=\"553 .739990234375\" data-recalc-dims=\"1\"><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;\"><\/span><\/p>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u56fe8 \u7ed3\u5408LRG\u8bc4\u5206\u548c\u4e34\u5e8a\u53c2\u6570\u8fdb\u884c\u7cbe\u786e\u9884\u6d4b\u7684\u5217\u7ebf\u56fe<\/span><\/section>\n<section style=\"margin-top: 0pt;margin-bottom: 16px;margin-left: 18pt;outline: 0px;text-indent: -18pt;font-size: 12pt;font-family: "Times New Roman";line-height: 1.75em;\"><strong style=\"outline: 0px;\">9.\u5bfb\u627e\u9ad8LRGS\u7ec4\u7684\u6f5c\u5728\u6cbb\u7597\u836f\u7269<\/strong><\/section>\n<section style=\"margin-left: 0pt;outline: 0px;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;text-indent: 0em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><span style=\"outline: 0px;\">\u4e3a\u4e86\u786e\u5b9a\u9ad8LRGS CRC\u60a3\u8005\u7684\u6f5c\u5728\u6cbb\u7597\u9009\u62e9\uff0c\u91c7\u7528\u4e86\u5316\u5b66\u836f\u7269\u548c\u9776\u5411\u836f\u7269\u7684\u7efc\u5408\u5206\u6790\u3002\u4eceCTRP\u6570\u636e\u96c6\u4e2d\uff0cGANT-61\u3001NSC23766\u548cPRIMA-1\u6210\u4e3a\u6f5c\u5728\u7684\u5019\u9009\u57fa\u56e0\uff08\u56fe9B\uff09\uff0c\u800cPRISM\u6570\u636e\u96c6\u7a81\u51fa\u4e86\u7f57\u7c73\u5fb7\u86cb\u767d\u9176\u3001<\/span><span class=\"wx_search_keyword_wrap\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;\">\u6d1b\u62c9\u66ff\u5c3c<\/span><span style=\"outline: 0px;\">\u3001\u66ff\u4e8c\u5511-\u78f7\u9178\u76d0\u7b49\uff08\u56fe9C\uff09\u3002\u8fd9\u4e9b\u836f\u7269\u7684AUC\u503c\u5728\u9ad8LRGS\u7ec4\u4e2d\u660e\u663e\u8f83\u4f4e\uff0c\u8868\u660e\u6709\u66f4\u597d\u7684\u654f\u611f\u6027\u3002\u6b64\u5916\uff0c\u5728\u4f4e\u98ce\u9669\u7ec4\u4e2d\uff0c\u987a\u94c2\u3001\u5409\u897f\u4ed6\u6ee8\u548c\u7d2b\u6749\u9187\u7684\u534a\u6291\u5236\u6d53\u5ea6\u503c\u660e\u663e\u4f4e\u4e8e\u9ad8\u98ce\u9669\u7ec4\uff0c\u63d0\u793a\u5bf9\u4f4e\u98ce\u9669\u60a3\u8005\u6709\u6f5c\u5728\u7684\u76ca\u5904\u3002\u76f8\u53cd\uff0c\u5409\u975e\u66ff\u5c3c\u5728\u9ad8\u5371\u7ec4\u4e2d\u7684\u534a\u6291\u5236\u6d53\u5ea6\u8f83\u4f4e\uff0c\u4f7f\u5176\u6210\u4e3a\u66f4\u9002\u5408\u8be5\u7ec4\u7684\u9009\u62e9\uff08\u56fe9D-G\uff09\u30029\u4e2aLRGS\u76f8\u5173\u57fa\u56e0\uff0c\u5305\u62ecARPC1B\u3001TERF2IP\u3001ARL4C\u3001UBE2I\u3001LGALS4\u3001SFPQ\u3001HMGN2\u3001LEPROTL1\u548cH2AFY\uff0c\u4e0e\u7279\u5f02\u6027\u5316\u7597\u836f\u7269\u7684\u654f\u611f\u6027\u76f8\u5173\uff08\u56fe9H\uff09\u3002<\/span><\/span><o:page style=\"outline: 0px;\"><\/o:page><\/section>\n<p style=\"margin-bottom: 8px;margin-left: 0pt;outline: 0px;text-align: center;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;\"><span style=\"outline: 0px;font-family: \u7b49\u7ebf;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018560\" data-ratio=\"1.4905109489051094\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_GjzvrnRBpZbaNltiaSsQ55WStXV6HQ.png?resize=553%2C825\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6YwHtcjt99MQrrN4ia8JdBMHf5wfblj54UYvISCkGggIxOO8GjzvrnRBpZbaNltiaSsQ55WStXV6HQ\/640?wx_fmt=png&tp=wxpic&wxfrom=5&wx_lazy=1&wx_co=1'\" data-type=\"png\" data-w=\"685\" height=\"825 .489990234375\" style=\"outline: 0px;visibility: visible !important;width: 553.734px !important;\" width=\"553 .739990234375\" data-recalc-dims=\"1\"><\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\"><\/span><\/p>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u56fe9 \u7ed3\u5408LRG\u8bc4\u5206\u548c\u4e34\u5e8a\u53c2\u6570\u8fdb\u884c\u7cbe\u786e\u9884\u6d4b\u7684\u5217\u7ebf\u56fe<\/span><o:page style=\"outline: 0px;\"><\/o:page><\/section>\n<section style=\"margin-left: 0pt;outline: 0px;text-indent: 0pt;font-size: 12pt;font-family: \u5b8b\u4f53;text-align: center;line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;font-weight: bold;color: rgb(0, 82, 255);\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/section>\n<section style=\"margin-left: 0pt;outline: 0px;font-size: 12pt;font-family: \u5b8b\u4f53;line-height: 1.75em;text-indent: 0em;\"><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;\">\u672c\u9879\u7814\u7a76\u901a\u8fc7\u6574\u5408\u80bf\u7624\u7ec4\u7ec7\u82af\u7247\u3001TCGA\u6570\u636e\u96c6\u3001GEO\u6570\u636e\u96c6\u7684\u7efc\u5408\u5206\u6790\uff0c\u7ed3\u5408\u8ba1\u7b97\u673a\u7814\u7a76\u548c\u4f53\u5916\u5b9e\u9a8c\uff0c\u786e\u5b9a\u4e86\u4e00\u4e2a\u80fd\u591f\u9884\u6d4b\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u9884\u540e\u768423\u4e2a\u57fa\u56e0\u7684\u4e73\u9170\u5316\u76f8\u5173\u57fa\u56e0\u98ce\u9669\u6a21\u578b\uff0c\u5728\u6539\u5584\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u7ba1\u7406\u548c\u589e\u5f3a\u6cbb\u7597\u6548\u679c\u65b9\u9762\u8868\u73b0\u51fa\u5de8\u5927\u7684\u6f5c\u529b\uff0c\u7279\u522b\u662f\u5728\u4ee3\u8c22\u548c\u514d\u75ab\u9003\u907f\u7684\u4ea4\u53c9\u70b9\u4e0a\u3002\u8fd9\u4e00\u53d1\u73b0\u5f3a\u8c03\u4e86\u7ed3\u76f4\u80a0\u764c\u4e2d\u6574\u4f53\u4e73\u9178\u5316\u7684\u4e34\u5e8a\u76f8\u5173\u6027\uff0c\u5e76\u4e3a\u7ed3\u76f4\u80a0\u764c\u4e2d\u9ad8\u4e73\u9178\u6d53\u5ea6\u7684\u673a\u5236\u7814\u7a76\u548c\u9776\u5411\u6cbb\u7597\u7b56\u7565\u5960\u5b9a\u4e86\u57fa\u7840\u3002\u770b\u6765\u9884\u540e\u6a21\u578b\u8fd8\u662f\u5f88\u5403\u9999\u5450\uff0c\u5b66\u4f1a\u6784\u5efa\u9884\u540e\u6a21\u578b\u7684\u624b\u6cd5\uff0c\u4e0b\u4e00\u7bc77\u5206+\u9ad8\u5206\u6587\u7ae0\u5c31\u662f\u4f60\u5566\uff01\u4f60\u5b66\u4f1a\u4e86\u5417~<\/span><span style=\"outline: 0px;font-size: 12pt;line-height: 24px;font-variant-numeric: normal;font-variant-east-asian: normal;font-variant-alternates: normal;font-variant-position: normal;color: rgb(255, 0, 0);font-weight: bold;\">\u5173\u6ce8\u9986\u957f\uff0c\u70ed\u70b9+\u601d\u8def\u624b\u628a\u624b\u6559\u4f60\uff01<\/span><\/section>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018563\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-53.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'&from=appmsg\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-wrap: wrap;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018565\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/15_7TvAyUibd1TPhJmZfialJtv6tu2SEg-4.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\"><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\"><br \/><\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" 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