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rgb(249, 172, 172) 0px 0px 5px 3px;\">\n<section style=\"text-align: center;transform: translate3d(2px, 0px, 0px);margin-top: -14px;margin-bottom: -14px;\" powered-by=\"xiumi.us\">\n<p>{ \u70b9\u51fb\u84dd\u5b57\uff0c\u5173\u6ce8\u6211\u4eec }<\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u4e0a\u56de\u5c0f\u5e08\u59b9\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e86ConsensusClusterPlus\uff0c\u5e76\u4e14\u7528GEO\u6570\u636e\u5e93\u4e2d\u7684GSE10245\u6570\u636e\u96c6\u8fdb\u884c\u4e86\u5b9e\u64cd\uff0c\u5927\u5bb6\u8fd8\u8bb0\u5f97\u8fd9\u4e24\u884c\u53ef\u4ee5\u5e26\u676514\u5f20\u56fe\u7684\u4ee3\u7801\u5417\uff5e<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">ccp <- ConsensusClusterPlus(data, maxK=<span class=\"code-snippet__number\">5<\/span>, reps=<span class=\"code-snippet__number\">100<\/span>, distance=<span class=\"code-snippet__string\">\"pearson\"<\/span>, clusterAlg=<span class=\"code-snippet__string\">\"km\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">icl <- calcICL(ccp)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;\">\n<section style=\"transform: scale(0.77);transform-origin: center center;margin-top: -6px;margin-bottom: -6px;\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 40px;height: 40px;vertical-align: top;overflow: hidden;background-color: rgb(249, 172, 172);border-width: 0px;border-radius: 65px;border-style: none;border-color: rgb(62, 62, 62);\">\n<section 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style=\"text-align: left;margin-top: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(62, 62, 62);\">\n<p><strong>\u4eca\u5929\u5c31\u8ba9\u5c0f\u5e08\u59b9\u6765\u8ddf\u5927\u5bb6\u89e3\u91ca\u4e00\u4e0b\u8fd914\u5f20\u56fe\u7684\u610f\u4e49\u5427\uff5e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-bottom: 8px;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(237, 164, 171);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u7b2c\u4e00\u5f20\u662f\u4e00\u81f4\u6027\u7684\u989c\u8272\u56fe\u4f8b\uff0c\u8868\u793a\u4e00\u81f4\u6027\u8d8a\u9ad8\uff0c\u989c\u8272\u8d8a\u6df1\u3002\u8fd9\u91cc\u805a\u7c7b\u5206\u6790\u7684\u4e00\u81f4\u6027\uff08cluster analysis consistency\uff09\u662f\u6307\u5728\u8fdb\u884c\u805a\u7c7b\u5206\u6790\u65f6\uff0c\u901a\u8fc7\u4e0d\u540c\u7684\u65b9\u6cd5\u6216\u53c2\u6570\u5f97\u5230\u7684\u805a\u7c7b\u7ed3\u679c\u4e4b\u95f4\u7684\u76f8\u4f3c\u7a0b\u5ea6\u6216\u4e00\u81f4\u6027\u3002\u5728\u805a\u7c7b\u5206\u6790\u4e2d\uff0c\u901a\u5e38\u4f1a\u4f7f\u7528\u4e0d\u540c\u7684\u805a\u7c7b\u7b97\u6cd5\u3001\u8ddd\u79bb\u5ea6\u91cf\u65b9\u6cd5\u3001\u805a\u7c7b\u6570\u76ee\u7b49\u53c2\u6570\uff0c\u8fd9\u4e9b\u4e0d\u540c\u7684\u9009\u62e9\u53ef\u80fd\u4f1a\u5bfc\u81f4\u4e0d\u540c\u7684\u805a\u7c7b\u7ed3\u679c\u3002\u56e0\u6b64\uff0c\u805a\u7c7b\u5206\u6790\u7684\u4e00\u81f4\u6027\u662f\u6307\u901a\u8fc7\u4e0d\u540c\u7684\u9009\u62e9\u5f97\u5230\u7684\u805a\u7c7b\u7ed3\u679c\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\u7a0b\u5ea6\uff0c\u5373\u4e0d\u540c\u7684\u9009\u62e9\u662f\u5426\u4f1a\u5bfc\u81f4\u76f8\u4f3c\u6216\u4e0d\u540c\u7684\u805a\u7c7b\u7ed3\u679c\u3002\u4e00\u81f4\u6027\u8d8a\u9ad8\uff0c\u8868\u793a\u4e24\u4e2a\u6837\u672c\u603b\u662f\u88ab\u5206\u5230\u4e00\u8d77\uff0c\u4e00\u81f4\u6027\u8d8a\u4f4e\uff0c\u5219\u8868\u793a\u4e24\u4e2a\u6837\u672c\u5f88\u5c11\u88ab\u5206\u5230\u4e00\u8d77\u3002<\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9241573033707865\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_dcxbeicsfPV0MZZAZicrrCmFVgxibg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNBcibXNksKj5nwUO369z32sEvGEp3dcxbeicsfPV0MZZAZicrrCmFVgxibg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"712\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u63a5\u4e0b\u6765\u7684\u56db\u5f20\u70ed\u56fe\u5bf9\u5e94\u7684\u5c31\u662f\u4e0d\u540c\u5206\u7c7b\u6570\u91cf\uff08\u6ce8\u610f\uff0c\u8fd9\u91cc\u6211\u4eec\u8bbe\u7f6e\u6700\u5927\u5206\u7c7b\u6570\u91cfmaxK\u4e3a5\uff0c\u6240\u4ee5\u4f1a\u6709\u5206\u4e3a2\u7c7b\u30013\u7c7b\u30014\u7c7b\u30015\u7c7b\u56db\u79cd\u60c5\u51b5\uff09<br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.38996138996139\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_AB2xan4s43LkowtLwzOgF2F6eFGS6g.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNSDiaxm9soeGA5kfl74EmsprWcAB2xan4s43LkowtLwzOgF2F6eFGS6g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"518\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.320754716981132\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_P4pHyb64Kkvncuh0FyicgicYtdFicA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNJrBJWRqgIq3DZ5vibtkUjvauxjwFP4pHyb64Kkvncuh0FyicgicYtdFicA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"530\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.193103448275862\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_FpXx1fpWNQibia2ib027SbqJTBaqCg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNK4G86A9OBZqJOUozrPIXpd59QvaFpXx1fpWNQibia2ib027SbqJTBaqCg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"580\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.2304964539007093\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_rC3TX3aHuOQpaayJ3K8JAQU4mT09dQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNFicjwFwsRvP0wVeLy04g34OKyrC3TX3aHuOQpaayJ3K8JAQU4mT09dQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"564\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u7b2c6\u5f20\u56fe\uff0c\u4e00\u81f4\u6027\u7d2f\u79ef\u5206\u5e03\u51fd\u6570\u56fe\uff0c\u8fd9\u4e5f\u662f\u7528\u4e8e\u8bc4\u4f30\u805a\u7c7b\u5206\u6790\u4e00\u81f4\u6027\u7684\u4e00\u79cd\u5e38\u7528\u53ef\u89c6\u5316\u5de5\u5177\u3002\u5b83\u901a\u5e38\u7528\u4e8e\u6bd4\u8f83\u4e0d\u540c\u805a\u7c7b\u65b9\u6cd5\u6216\u53c2\u6570\u4e0b\u5f97\u5230\u7684\u805a\u7c7b\u7ed3\u679c\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\u7a0b\u5ea6\u3002<br \/><\/p>\n<p style=\"white-space: normal;\">\u5728CCDF\u56fe\u4e2d\uff0cx\u8f74\u8868\u793a\u805a\u7c7b\u7ed3\u679c\u7684\u4e00\u81f4\u6027\u5f97\u5206\uff0c\u901a\u5e38\u662f\u4f7f\u7528\u5185\u90e8\u8bc4\u4ef7\u6307\u6807\uff08\u5982\u8f6e\u5ed3\u7cfb\u6570\u3001Davies-Bouldin\u6307\u6570\u7b49\uff09\u6216\u5916\u90e8\u8bc4\u4ef7\u6307\u6807\uff08\u5982Adjusted Rand Index\u3001Normalized Mutual Information\u7b49\uff09\u8fdb\u884c\u8ba1\u7b97\u3002y\u8f74\u8868\u793a\u4e00\u81f4\u6027\u5f97\u5206\u7684\u5206\u4f4d\u6570\uff0c\u901a\u5e38\u662f\u4ece0\u52301\u7684\u8303\u56f4\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5805555555555556\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_jm4EPUn75v8lkWCwLQHCvfkvRScCxg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNhKypWqeia12SpPAuDlSGOrZAVjm4EPUn75v8lkWCwLQHCvfkvRScCxg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5177\u4f53\u6765\u8bf4\uff0cCCDF\u56fe\u7684\u7ed8\u5236\u8fc7\u7a0b\u901a\u5e38\u5305\u62ec\u4ee5\u4e0b\u51e0\u4e2a\u6b65\u9aa4\uff1a<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<ol style=\"padding-left: 40px;list-style-position: outside;\" class=\"list-paddingleft-1\" powered-by=\"xiumi.us\">\n<li>\n<p>\u5bf9\u4e8e\u4e0d\u540c\u7684\u805a\u7c7b\u65b9\u6cd5\u6216\u53c2\u6570\uff0c\u8ba1\u7b97\u5176\u5bf9\u5e94\u7684\u4e00\u81f4\u6027\u5f97\u5206\uff0c\u5e76\u5c06\u8fd9\u4e9b\u5f97\u5206\u6309\u7167\u4ece\u9ad8\u5230\u4f4e\u7684\u987a\u5e8f\u6392\u5217\u3002<\/p>\n<\/li>\n<li>\n<p>\u5bf9\u4e8e\u6bcf\u4e2a\u4e00\u81f4\u6027\u5f97\u5206\uff0c\u8ba1\u7b97\u5176\u5bf9\u5e94\u7684\u5206\u4f4d\u6570\u3002\u4f8b\u5982\uff0c\u5982\u679c\u670910\u4e2a\u4e00\u81f4\u6027\u5f97\u5206\uff0c\u5176\u4e2d\u6700\u9ad8\u7684\u4e00\u81f4\u6027\u5f97\u5206\u7684\u5206\u4f4d\u6570\u4e3a1\uff0c\u6700\u4f4e\u7684\u4e00\u81f4\u6027\u5f97\u5206\u7684\u5206\u4f4d\u6570\u4e3a0.1\u3002<\/p>\n<\/li>\n<li>\n<p>\u5c06\u4e00\u81f4\u6027\u5f97\u5206\u6309\u7167\u4ece\u9ad8\u5230\u4f4e\u7684\u987a\u5e8f\u7ed8\u5236\u5728x\u8f74\u4e0a\uff0c\u5c06\u5206\u4f4d\u6570\u7ed8\u5236\u5728y\u8f74\u4e0a\uff0c\u7136\u540e\u8fde\u63a5\u6240\u6709\u6570\u636e\u70b9\uff0c\u5f62\u6210\u4e00\u6761\u66f2\u7ebf\u3002\u8fd9\u6761\u66f2\u7ebf\u8868\u793a\u4e86\u4e0d\u540c\u4e00\u81f4\u6027\u5f97\u5206\u5728\u6570\u636e\u96c6\u4e2d\u7684\u5206\u5e03\u60c5\u51b5\u3002<\/p>\n<\/li>\n<li>\n<p>\u5f53CDF\u8fbe\u5230\u4e00\u4e2a\u8fd1\u4f3c\u6700\u5927\u503c\u65f6\uff0c\u6b64\u65f6\u7684\u805a\u7c7b\u5206\u6790\u7ed3\u679c\u6700\u53ef\u9760\uff0c\u5bf9\u5e94\u7684k\u503c\u5c31\u662f\u6700\u4f73k\u503c\uff0c\u5f97\u5230\u7684\u5206\u7c7b\u5c31\u662f\u6700\u4f73\u5206\u7c7b\u3002\u5373\u8003\u8651CDF\u4e0b\u964d\u5761\u5ea6\u5c0f\u7684k\u503c\u3002<br 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normal;\">\u901a\u8fc7\u89c2\u5bdfCCDF\u56fe\uff0c\u6211\u4eec\u53ef\u4ee5\u6bd4\u8f83\u4e0d\u540c\u805a\u7c7b\u65b9\u6cd5\u6216\u53c2\u6570\u4e0b\u5f97\u5230\u7684\u805a\u7c7b\u7ed3\u679c\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\u7a0b\u5ea6\u3002\u5982\u679c\u4e0d\u540c\u805a\u7c7b\u65b9\u6cd5\u6216\u53c2\u6570\u5f97\u5230\u7684\u805a\u7c7b\u7ed3\u679c\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\u7a0b\u5ea6\u8f83\u9ad8\uff0c\u90a3\u4e48CCDF\u56fe\u7684\u66f2\u7ebf\u4f1a\u6bd4\u8f83\u9661\u5ced\uff0c\u8868\u793a\u9ad8\u4e00\u81f4\u6027\u5f97\u5206\u7684\u805a\u7c7b\u7ed3\u679c\u5360\u636e\u4e86\u8f83\u5927\u7684\u6bd4\u4f8b\u3002\u76f8\u53cd\uff0c\u5982\u679c\u4e0d\u540c\u805a\u7c7b\u65b9\u6cd5\u6216\u53c2\u6570\u5f97\u5230\u7684\u805a\u7c7b\u7ed3\u679c\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\u7a0b\u5ea6\u8f83\u4f4e\uff0c\u90a3\u4e48CCDF\u56fe\u7684\u66f2\u7ebf\u4f1a\u6bd4\u8f83\u5e73\u7f13\uff0c\u8868\u793a\u9ad8\u4e00\u81f4\u6027\u5f97\u5206\u7684\u805a\u7c7b\u7ed3\u679c\u5360\u636e\u4e86\u8f83\u5c0f\u7684\u6bd4\u4f8b\u3002<\/p>\n<p style=\"white-space: normal;\">\u7b2c7\u5f20\u662f\u788e\u77f3\u56fe\uff0c\u8fd9\u5f20\u56fe\u5c55\u793a\u4e86 k \u548c k-1 \u76f8\u6bd4CDF\u66f2\u7ebf\u4e0b\u9762\u79ef\u7684\u76f8\u5bf9\u53d8\u5316\u3002\u5f53k = 2\u65f6\uff0c\u56e0\u4e3a\u6ca1\u6709k=1\uff0c\u6240\u4ee5\u7b2c\u4e00\u4e2a\u70b9\u8868\u793a\u7684\u662fk=2\u65f6CDF\u66f2\u7ebf\u4e0b\u603b\u9762\u79ef\u3002\u53ef\u4ee5\u770b\u5230\u5206\u7c7bk\u4ece3\u589e\u52a0\u52304\u65f6\u9762\u79ef\u53d8\u5316\u9887\u5927\uff0c\u800c\u4ece4\u589e\u52a0\u52305\u65f6\u53d8\u5316\u4e0d\u5927\uff0c\u7531\u6b64\u53ef\u89c1\u5206\u7c7b\u65704\u662f\u6bd4\u8f83\u5408\u9002\u7684\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6018518518518519\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_nFdaXZVBTGdRSAOguVicdbTUujIsWQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNmjcJibdcdJ3LeHpADVvscMAtRicnFdaXZVBTGdRSAOguVicdbTUujIsWQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u7b2c8\u5f20\u662f\u8ddf\u8e2a\u56fe\uff0ctracking plot<br \/><\/p>\n<p style=\"white-space: normal;\">\u8be5\u56fe\u50cf\u4e0b\u65b9\u7684\u9ed1\u8272\u6761\u7eb9\u8868\u793a\u6837\u54c1\uff0c\u5c55\u793a\u7684\u662f\u6837\u54c1\u5728k\u53d6\u4e0d\u540c\u7684\u503c\u65f6\uff0c\u5f52\u5c5e\u7684\u5206\u7c7b\u60c5\u51b5\uff0c\u4e0d\u540c\u989c\u8272\u7684\u8272\u5757\u4ee3\u8868\u4e0d\u540c\u7684\u5206\u7c7b\u3002\u53d6\u4e0d\u540ck\u503c\u524d\u540e\u7ecf\u5e38\u6539\u53d8\u989c\u8272\u5206\u7c7b\u7684\u6837\u54c1\u4ee3\u8868\u5176\u5206\u7c7b\u4e0d\u7a33\u5b9a\u3002\u82e5\u5206\u7c7b\u4e0d\u7a33\u5b9a\u7684\u6837\u672c\u592a\u591a\uff0c\u5219\u8bf4\u660e\u8be5k\u503c\u4e0b\u7684\u5206\u7c7b\u4e0d\u7a33\u5b9a<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6240740740740741\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_w8aA30ogwVBQnkic5mMo01K06MtxKQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNGq13yFCfqY9lWWia3ia0KagF21Uw8aA30ogwVBQnkic5mMo01K06MtxKQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u63a5\u4e0b\u6765\u518d\u89e3\u91ca\u4e00\u4e0bcalcICL\u5f97\u5230\u7684\u56fe\u50cf\uff5e<br \/><\/p>\n<p style=\"white-space: normal;\">\u524d\u56db\u5f20\u56fe\u662f\u6837\u672c\u4e00\u81f4\u6027\u56fe\uff0c\u4ed6\u4eec\u7684\u7eb5\u5750\u6807\u4ee3\u8868Item-consensus values\u3002k\u503c\u4e0d\u540c\u65f6\uff0c\u6bcf\u4e2a\u6837\u672c\u90fd\u4f1a\u6709\u4e00\u4e2a\u5bf9\u5e94\u4e0d\u540c\u7c07\u7684item-consensus values\u3002\u7ad6\u6761\u4ee3\u8868\u6bcf\u4e00\u4e2a\u6837\u672c\uff0c\u7ad6\u6761\u7684\u9ad8\u5ea6\u4ee3\u8868\u8be5\u6837\u672c\u7684\u603bitem-consensus values\u3002\u6bcf\u4e2a\u6837\u672c\u7684\u4e0a\u65b9\u90fd\u6709\u4e00\u4e2a\u5c0f\u53c9\u53c9\uff0c\u5c0f\u53c9\u53c9\u7684\u989c\u8272\u4ee3\u8868\u8be5\u6837\u672c\u88ab\u5206\u5230\u4e86\u54ea\u4e00\u7c07\u3002\u4ece\u8fd9\u5f20\u56fe\uff0c\u53ef\u4ee5\u770b\u5230\u6bcf\u4e2a\u6837\u672c\u7684\u5206\u7c7b\u662f\u5426\u8db3\u591f\u201c\u7eaf\u51c0\u201d\uff0c\u4ece\u800c\u5e2e\u52a9\u51b3\u5b9ak\u503c\u3002\u4f8b\u5982\u5f53k=5\u65f6\uff0c\u6837\u672c\u7684\u5206\u7c7b\u53d8\u5f97\u6ca1\u6709\u90a3\u4e48\u7eaf\u51c0\uff0c\u8bf4\u660ek=4\u624d\u662f\u5408\u9002\u7684\uff0c\u8fd9\u548c\u788e\u77f3\u56fe\u7ed9\u5230\u7684\u7ed3\u679c\u4e00\u81f4\u3002\u6761\u5f62\u7684\u77e9\u5f62\u6309\u4ece\u4e0b\u5230\u4e0a\u9012\u589e\u7684\u503c\u6392\u5217\u3002\u9876\u90e8\u7684\u661f\u53f7\u8868\u793a\u6bcf\u4e2a\u6837\u672c\u7684consensus cluster\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5638888888888889\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_ArphGwdHdIB4aglgrISWGBsP3s0fhA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNq6iavtW8SNHMkGKyZ5rDFSrOHArphGwdHdIB4aglgrISWGBsP3s0fhA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.18425925925925926\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_s2ktibslQxh75gE8UojUz8msMEpwVA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNDQQkQoXX07fWMYcOMnnfq5o6Js2ktibslQxh75gE8UojUz8msMEpwVA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u63a5\u4e0b\u6765\u662f\u805a\u7c7b\u4e00\u81f4\u6027\u56fe \u6b64\u56fe\u5c55\u793a\u7684\u662f\u4e0d\u540ck\u503c\u4e0b\uff0c\u6bcf\u4e2a\u5206\u7c7b\u7684cluster-consensus value\uff08\u8be5\u7c07\u4e2d\u6210\u5458pairwise consensus values\u7684\u5747\u503c\uff09\u3002\u8be5\u503c\u8d8a\u9ad8\uff08\u4f4e\uff09\u4ee3\u8868\u7a33\u5b9a\u6027\u8d8a\u9ad8\uff08\u4f4e\uff09\u3002\u53ef\u7528\u4e8e\u5224\u65ad\u540c\u4e00k\u503c\u4e0b\u4ee5\u53ca\u4e0d\u540ck\u503c\u4e4b\u95f4cluster-consensus value\u7684\u9ad8\u4f4e\u3002<\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.1925925925925926\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_aUtogZCbFibhad76jFwaF6bOYpUFZw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNogvTpxnLicb3CVh80kq0j6zmkfiaUtogZCbFibhad76jFwaF6bOYpUFZw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: 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nowrap;\">\n<section style=\"margin-right: 10px;display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;height: auto;align-self: center;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"background-color: rgb(249, 172, 172);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"margin-right: 10px;padding-right: 8px;padding-left: 8px;display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;border-style: solid;border-width: 1px;border-color: rgb(249, 172, 172);\">\n<section powered-by=\"xiumi.us\" style=\"text-align: justify;color: rgb(249, 172, 172);\">\n<p>E<\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 10px;padding-right: 8px;padding-left: 8px;display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 0 0 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rgb(249, 172, 172) 0px 0px 5px 3px;\">\n<section style=\"text-align: center;transform: translate3d(2px, 0px, 0px);margin-top: -14px;margin-bottom: -14px;\" powered-by=\"xiumi.us\">\n<p>{ \u70b9\u51fb\u84dd\u5b57\uff0c\u5173\u6ce8\u6211\u4eec }<\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u4e0a\u56de\u5c0f\u5e08\u59b9\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e86ConsensusClusterPlus\uff0c\u5e76\u4e14\u7528GEO\u6570\u636e\u5e93\u4e2d\u7684GSE10245\u6570\u636e\u96c6\u8fdb\u884c\u4e86\u5b9e\u64cd\uff0c\u5927\u5bb6\u8fd8\u8bb0\u5f97\u8fd9\u4e24\u884c\u53ef\u4ee5\u5e26\u676514\u5f20\u56fe\u7684\u4ee3\u7801\u5417\uff5e<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">ccp <- ConsensusClusterPlus(data, maxK=<span class=\"code-snippet__number\">5<\/span>, reps=<span class=\"code-snippet__number\">100<\/span>, distance=<span class=\"code-snippet__string\">\"pearson\"<\/span>, clusterAlg=<span class=\"code-snippet__string\">\"km\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">icl <- calcICL(ccp)<\/span><\/code><\/pre>\n<\/section>\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;\">\n<section style=\"transform: scale(0.77);transform-origin: center center;margin-top: -6px;margin-bottom: -6px;\" powered-by=\"xiumi.us\">\n<section style=\"\">\n<section style=\"display: inline-block;width: 40px;height: 40px;vertical-align: top;overflow: hidden;background-color: rgb(249, 172, 172);border-width: 0px;border-radius: 65px;border-style: none;border-color: rgb(62, 62, 62);\">\n<section 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inline-block;vertical-align: top;width: 20px;flex: 0 0 auto;align-self: flex-start;height: auto;line-height: 0;border-width: 0px;border-style: none;border-color: rgb(62, 62, 62);overflow: hidden;\">\n<section style=\"transform: rotateZ(305deg);\" powered-by=\"xiumi.us\">\n<section style=\"text-align: left;margin-right: 0%;margin-bottom: 18px;margin-left: 0%;transform: translate3d(-13px, 0px, 0px);\">\n<section style=\"display: inline-block;width: 20px;height: 8px;vertical-align: top;overflow: hidden;background-color: rgb(255, 255, 255);border-radius: 50%;border-width: 0px;border-style: none;border-color: rgb(62, 62, 62);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 100 100 0%;height: auto;padding-left: 10px;\">\n<section style=\"text-align: left;margin-top: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(62, 62, 62);\">\n<p><strong>\u4eca\u5929\u5c31\u8ba9\u5c0f\u5e08\u59b9\u6765\u8ddf\u5927\u5bb6\u89e3\u91ca\u4e00\u4e0b\u8fd914\u5f20\u56fe\u7684\u610f\u4e49\u5427\uff5e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-bottom: 8px;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(237, 164, 171);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u7b2c\u4e00\u5f20\u662f\u4e00\u81f4\u6027\u7684\u989c\u8272\u56fe\u4f8b\uff0c\u8868\u793a\u4e00\u81f4\u6027\u8d8a\u9ad8\uff0c\u989c\u8272\u8d8a\u6df1\u3002\u8fd9\u91cc\u805a\u7c7b\u5206\u6790\u7684\u4e00\u81f4\u6027\uff08cluster analysis consistency\uff09\u662f\u6307\u5728\u8fdb\u884c\u805a\u7c7b\u5206\u6790\u65f6\uff0c\u901a\u8fc7\u4e0d\u540c\u7684\u65b9\u6cd5\u6216\u53c2\u6570\u5f97\u5230\u7684\u805a\u7c7b\u7ed3\u679c\u4e4b\u95f4\u7684\u76f8\u4f3c\u7a0b\u5ea6\u6216\u4e00\u81f4\u6027\u3002\u5728\u805a\u7c7b\u5206\u6790\u4e2d\uff0c\u901a\u5e38\u4f1a\u4f7f\u7528\u4e0d\u540c\u7684\u805a\u7c7b\u7b97\u6cd5\u3001\u8ddd\u79bb\u5ea6\u91cf\u65b9\u6cd5\u3001\u805a\u7c7b\u6570\u76ee\u7b49\u53c2\u6570\uff0c\u8fd9\u4e9b\u4e0d\u540c\u7684\u9009\u62e9\u53ef\u80fd\u4f1a\u5bfc\u81f4\u4e0d\u540c\u7684\u805a\u7c7b\u7ed3\u679c\u3002\u56e0\u6b64\uff0c\u805a\u7c7b\u5206\u6790\u7684\u4e00\u81f4\u6027\u662f\u6307\u901a\u8fc7\u4e0d\u540c\u7684\u9009\u62e9\u5f97\u5230\u7684\u805a\u7c7b\u7ed3\u679c\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\u7a0b\u5ea6\uff0c\u5373\u4e0d\u540c\u7684\u9009\u62e9\u662f\u5426\u4f1a\u5bfc\u81f4\u76f8\u4f3c\u6216\u4e0d\u540c\u7684\u805a\u7c7b\u7ed3\u679c\u3002\u4e00\u81f4\u6027\u8d8a\u9ad8\uff0c\u8868\u793a\u4e24\u4e2a\u6837\u672c\u603b\u662f\u88ab\u5206\u5230\u4e00\u8d77\uff0c\u4e00\u81f4\u6027\u8d8a\u4f4e\uff0c\u5219\u8868\u793a\u4e24\u4e2a\u6837\u672c\u5f88\u5c11\u88ab\u5206\u5230\u4e00\u8d77\u3002<\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9241573033707865\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_dcxbeicsfPV0MZZAZicrrCmFVgxibg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNBcibXNksKj5nwUO369z32sEvGEp3dcxbeicsfPV0MZZAZicrrCmFVgxibg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"712\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u63a5\u4e0b\u6765\u7684\u56db\u5f20\u70ed\u56fe\u5bf9\u5e94\u7684\u5c31\u662f\u4e0d\u540c\u5206\u7c7b\u6570\u91cf\uff08\u6ce8\u610f\uff0c\u8fd9\u91cc\u6211\u4eec\u8bbe\u7f6e\u6700\u5927\u5206\u7c7b\u6570\u91cfmaxK\u4e3a5\uff0c\u6240\u4ee5\u4f1a\u6709\u5206\u4e3a2\u7c7b\u30013\u7c7b\u30014\u7c7b\u30015\u7c7b\u56db\u79cd\u60c5\u51b5\uff09<br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.38996138996139\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_AB2xan4s43LkowtLwzOgF2F6eFGS6g.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNSDiaxm9soeGA5kfl74EmsprWcAB2xan4s43LkowtLwzOgF2F6eFGS6g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"518\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.320754716981132\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_P4pHyb64Kkvncuh0FyicgicYtdFicA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNJrBJWRqgIq3DZ5vibtkUjvauxjwFP4pHyb64Kkvncuh0FyicgicYtdFicA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"530\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.193103448275862\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_FpXx1fpWNQibia2ib027SbqJTBaqCg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNK4G86A9OBZqJOUozrPIXpd59QvaFpXx1fpWNQibia2ib027SbqJTBaqCg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"580\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.2304964539007093\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_rC3TX3aHuOQpaayJ3K8JAQU4mT09dQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNFicjwFwsRvP0wVeLy04g34OKyrC3TX3aHuOQpaayJ3K8JAQU4mT09dQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"564\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u7b2c6\u5f20\u56fe\uff0c\u4e00\u81f4\u6027\u7d2f\u79ef\u5206\u5e03\u51fd\u6570\u56fe\uff0c\u8fd9\u4e5f\u662f\u7528\u4e8e\u8bc4\u4f30\u805a\u7c7b\u5206\u6790\u4e00\u81f4\u6027\u7684\u4e00\u79cd\u5e38\u7528\u53ef\u89c6\u5316\u5de5\u5177\u3002\u5b83\u901a\u5e38\u7528\u4e8e\u6bd4\u8f83\u4e0d\u540c\u805a\u7c7b\u65b9\u6cd5\u6216\u53c2\u6570\u4e0b\u5f97\u5230\u7684\u805a\u7c7b\u7ed3\u679c\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\u7a0b\u5ea6\u3002<br \/><\/p>\n<p style=\"white-space: normal;\">\u5728CCDF\u56fe\u4e2d\uff0cx\u8f74\u8868\u793a\u805a\u7c7b\u7ed3\u679c\u7684\u4e00\u81f4\u6027\u5f97\u5206\uff0c\u901a\u5e38\u662f\u4f7f\u7528\u5185\u90e8\u8bc4\u4ef7\u6307\u6807\uff08\u5982\u8f6e\u5ed3\u7cfb\u6570\u3001Davies-Bouldin\u6307\u6570\u7b49\uff09\u6216\u5916\u90e8\u8bc4\u4ef7\u6307\u6807\uff08\u5982Adjusted Rand Index\u3001Normalized Mutual Information\u7b49\uff09\u8fdb\u884c\u8ba1\u7b97\u3002y\u8f74\u8868\u793a\u4e00\u81f4\u6027\u5f97\u5206\u7684\u5206\u4f4d\u6570\uff0c\u901a\u5e38\u662f\u4ece0\u52301\u7684\u8303\u56f4\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5805555555555556\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_jm4EPUn75v8lkWCwLQHCvfkvRScCxg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNhKypWqeia12SpPAuDlSGOrZAVjm4EPUn75v8lkWCwLQHCvfkvRScCxg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5177\u4f53\u6765\u8bf4\uff0cCCDF\u56fe\u7684\u7ed8\u5236\u8fc7\u7a0b\u901a\u5e38\u5305\u62ec\u4ee5\u4e0b\u51e0\u4e2a\u6b65\u9aa4\uff1a<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<\/section>\n<ol style=\"padding-left: 40px;list-style-position: outside;\" class=\"list-paddingleft-1\" powered-by=\"xiumi.us\">\n<li>\n<p>\u5bf9\u4e8e\u4e0d\u540c\u7684\u805a\u7c7b\u65b9\u6cd5\u6216\u53c2\u6570\uff0c\u8ba1\u7b97\u5176\u5bf9\u5e94\u7684\u4e00\u81f4\u6027\u5f97\u5206\uff0c\u5e76\u5c06\u8fd9\u4e9b\u5f97\u5206\u6309\u7167\u4ece\u9ad8\u5230\u4f4e\u7684\u987a\u5e8f\u6392\u5217\u3002<\/p>\n<\/li>\n<li>\n<p>\u5bf9\u4e8e\u6bcf\u4e2a\u4e00\u81f4\u6027\u5f97\u5206\uff0c\u8ba1\u7b97\u5176\u5bf9\u5e94\u7684\u5206\u4f4d\u6570\u3002\u4f8b\u5982\uff0c\u5982\u679c\u670910\u4e2a\u4e00\u81f4\u6027\u5f97\u5206\uff0c\u5176\u4e2d\u6700\u9ad8\u7684\u4e00\u81f4\u6027\u5f97\u5206\u7684\u5206\u4f4d\u6570\u4e3a1\uff0c\u6700\u4f4e\u7684\u4e00\u81f4\u6027\u5f97\u5206\u7684\u5206\u4f4d\u6570\u4e3a0.1\u3002<\/p>\n<\/li>\n<li>\n<p>\u5c06\u4e00\u81f4\u6027\u5f97\u5206\u6309\u7167\u4ece\u9ad8\u5230\u4f4e\u7684\u987a\u5e8f\u7ed8\u5236\u5728x\u8f74\u4e0a\uff0c\u5c06\u5206\u4f4d\u6570\u7ed8\u5236\u5728y\u8f74\u4e0a\uff0c\u7136\u540e\u8fde\u63a5\u6240\u6709\u6570\u636e\u70b9\uff0c\u5f62\u6210\u4e00\u6761\u66f2\u7ebf\u3002\u8fd9\u6761\u66f2\u7ebf\u8868\u793a\u4e86\u4e0d\u540c\u4e00\u81f4\u6027\u5f97\u5206\u5728\u6570\u636e\u96c6\u4e2d\u7684\u5206\u5e03\u60c5\u51b5\u3002<\/p>\n<\/li>\n<li>\n<p>\u5f53CDF\u8fbe\u5230\u4e00\u4e2a\u8fd1\u4f3c\u6700\u5927\u503c\u65f6\uff0c\u6b64\u65f6\u7684\u805a\u7c7b\u5206\u6790\u7ed3\u679c\u6700\u53ef\u9760\uff0c\u5bf9\u5e94\u7684k\u503c\u5c31\u662f\u6700\u4f73k\u503c\uff0c\u5f97\u5230\u7684\u5206\u7c7b\u5c31\u662f\u6700\u4f73\u5206\u7c7b\u3002\u5373\u8003\u8651CDF\u4e0b\u964d\u5761\u5ea6\u5c0f\u7684k\u503c\u3002<br 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normal;\">\u901a\u8fc7\u89c2\u5bdfCCDF\u56fe\uff0c\u6211\u4eec\u53ef\u4ee5\u6bd4\u8f83\u4e0d\u540c\u805a\u7c7b\u65b9\u6cd5\u6216\u53c2\u6570\u4e0b\u5f97\u5230\u7684\u805a\u7c7b\u7ed3\u679c\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\u7a0b\u5ea6\u3002\u5982\u679c\u4e0d\u540c\u805a\u7c7b\u65b9\u6cd5\u6216\u53c2\u6570\u5f97\u5230\u7684\u805a\u7c7b\u7ed3\u679c\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\u7a0b\u5ea6\u8f83\u9ad8\uff0c\u90a3\u4e48CCDF\u56fe\u7684\u66f2\u7ebf\u4f1a\u6bd4\u8f83\u9661\u5ced\uff0c\u8868\u793a\u9ad8\u4e00\u81f4\u6027\u5f97\u5206\u7684\u805a\u7c7b\u7ed3\u679c\u5360\u636e\u4e86\u8f83\u5927\u7684\u6bd4\u4f8b\u3002\u76f8\u53cd\uff0c\u5982\u679c\u4e0d\u540c\u805a\u7c7b\u65b9\u6cd5\u6216\u53c2\u6570\u5f97\u5230\u7684\u805a\u7c7b\u7ed3\u679c\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\u7a0b\u5ea6\u8f83\u4f4e\uff0c\u90a3\u4e48CCDF\u56fe\u7684\u66f2\u7ebf\u4f1a\u6bd4\u8f83\u5e73\u7f13\uff0c\u8868\u793a\u9ad8\u4e00\u81f4\u6027\u5f97\u5206\u7684\u805a\u7c7b\u7ed3\u679c\u5360\u636e\u4e86\u8f83\u5c0f\u7684\u6bd4\u4f8b\u3002<\/p>\n<p style=\"white-space: normal;\">\u7b2c7\u5f20\u662f\u788e\u77f3\u56fe\uff0c\u8fd9\u5f20\u56fe\u5c55\u793a\u4e86 k \u548c k-1 \u76f8\u6bd4CDF\u66f2\u7ebf\u4e0b\u9762\u79ef\u7684\u76f8\u5bf9\u53d8\u5316\u3002\u5f53k = 2\u65f6\uff0c\u56e0\u4e3a\u6ca1\u6709k=1\uff0c\u6240\u4ee5\u7b2c\u4e00\u4e2a\u70b9\u8868\u793a\u7684\u662fk=2\u65f6CDF\u66f2\u7ebf\u4e0b\u603b\u9762\u79ef\u3002\u53ef\u4ee5\u770b\u5230\u5206\u7c7bk\u4ece3\u589e\u52a0\u52304\u65f6\u9762\u79ef\u53d8\u5316\u9887\u5927\uff0c\u800c\u4ece4\u589e\u52a0\u52305\u65f6\u53d8\u5316\u4e0d\u5927\uff0c\u7531\u6b64\u53ef\u89c1\u5206\u7c7b\u65704\u662f\u6bd4\u8f83\u5408\u9002\u7684\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6018518518518519\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_nFdaXZVBTGdRSAOguVicdbTUujIsWQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNmjcJibdcdJ3LeHpADVvscMAtRicnFdaXZVBTGdRSAOguVicdbTUujIsWQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u7b2c8\u5f20\u662f\u8ddf\u8e2a\u56fe\uff0ctracking plot<br \/><\/p>\n<p style=\"white-space: normal;\">\u8be5\u56fe\u50cf\u4e0b\u65b9\u7684\u9ed1\u8272\u6761\u7eb9\u8868\u793a\u6837\u54c1\uff0c\u5c55\u793a\u7684\u662f\u6837\u54c1\u5728k\u53d6\u4e0d\u540c\u7684\u503c\u65f6\uff0c\u5f52\u5c5e\u7684\u5206\u7c7b\u60c5\u51b5\uff0c\u4e0d\u540c\u989c\u8272\u7684\u8272\u5757\u4ee3\u8868\u4e0d\u540c\u7684\u5206\u7c7b\u3002\u53d6\u4e0d\u540ck\u503c\u524d\u540e\u7ecf\u5e38\u6539\u53d8\u989c\u8272\u5206\u7c7b\u7684\u6837\u54c1\u4ee3\u8868\u5176\u5206\u7c7b\u4e0d\u7a33\u5b9a\u3002\u82e5\u5206\u7c7b\u4e0d\u7a33\u5b9a\u7684\u6837\u672c\u592a\u591a\uff0c\u5219\u8bf4\u660e\u8be5k\u503c\u4e0b\u7684\u5206\u7c7b\u4e0d\u7a33\u5b9a<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6240740740740741\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_w8aA30ogwVBQnkic5mMo01K06MtxKQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNGq13yFCfqY9lWWia3ia0KagF21Uw8aA30ogwVBQnkic5mMo01K06MtxKQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u63a5\u4e0b\u6765\u518d\u89e3\u91ca\u4e00\u4e0bcalcICL\u5f97\u5230\u7684\u56fe\u50cf\uff5e<br \/><\/p>\n<p style=\"white-space: normal;\">\u524d\u56db\u5f20\u56fe\u662f\u6837\u672c\u4e00\u81f4\u6027\u56fe\uff0c\u4ed6\u4eec\u7684\u7eb5\u5750\u6807\u4ee3\u8868Item-consensus values\u3002k\u503c\u4e0d\u540c\u65f6\uff0c\u6bcf\u4e2a\u6837\u672c\u90fd\u4f1a\u6709\u4e00\u4e2a\u5bf9\u5e94\u4e0d\u540c\u7c07\u7684item-consensus values\u3002\u7ad6\u6761\u4ee3\u8868\u6bcf\u4e00\u4e2a\u6837\u672c\uff0c\u7ad6\u6761\u7684\u9ad8\u5ea6\u4ee3\u8868\u8be5\u6837\u672c\u7684\u603bitem-consensus values\u3002\u6bcf\u4e2a\u6837\u672c\u7684\u4e0a\u65b9\u90fd\u6709\u4e00\u4e2a\u5c0f\u53c9\u53c9\uff0c\u5c0f\u53c9\u53c9\u7684\u989c\u8272\u4ee3\u8868\u8be5\u6837\u672c\u88ab\u5206\u5230\u4e86\u54ea\u4e00\u7c07\u3002\u4ece\u8fd9\u5f20\u56fe\uff0c\u53ef\u4ee5\u770b\u5230\u6bcf\u4e2a\u6837\u672c\u7684\u5206\u7c7b\u662f\u5426\u8db3\u591f\u201c\u7eaf\u51c0\u201d\uff0c\u4ece\u800c\u5e2e\u52a9\u51b3\u5b9ak\u503c\u3002\u4f8b\u5982\u5f53k=5\u65f6\uff0c\u6837\u672c\u7684\u5206\u7c7b\u53d8\u5f97\u6ca1\u6709\u90a3\u4e48\u7eaf\u51c0\uff0c\u8bf4\u660ek=4\u624d\u662f\u5408\u9002\u7684\uff0c\u8fd9\u548c\u788e\u77f3\u56fe\u7ed9\u5230\u7684\u7ed3\u679c\u4e00\u81f4\u3002\u6761\u5f62\u7684\u77e9\u5f62\u6309\u4ece\u4e0b\u5230\u4e0a\u9012\u589e\u7684\u503c\u6392\u5217\u3002\u9876\u90e8\u7684\u661f\u53f7\u8868\u793a\u6bcf\u4e2a\u6837\u672c\u7684consensus cluster\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5638888888888889\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_ArphGwdHdIB4aglgrISWGBsP3s0fhA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNq6iavtW8SNHMkGKyZ5rDFSrOHArphGwdHdIB4aglgrISWGBsP3s0fhA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.18425925925925926\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_s2ktibslQxh75gE8UojUz8msMEpwVA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNDQQkQoXX07fWMYcOMnnfq5o6Js2ktibslQxh75gE8UojUz8msMEpwVA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u63a5\u4e0b\u6765\u662f\u805a\u7c7b\u4e00\u81f4\u6027\u56fe \u6b64\u56fe\u5c55\u793a\u7684\u662f\u4e0d\u540ck\u503c\u4e0b\uff0c\u6bcf\u4e2a\u5206\u7c7b\u7684cluster-consensus value\uff08\u8be5\u7c07\u4e2d\u6210\u5458pairwise consensus values\u7684\u5747\u503c\uff09\u3002\u8be5\u503c\u8d8a\u9ad8\uff08\u4f4e\uff09\u4ee3\u8868\u7a33\u5b9a\u6027\u8d8a\u9ad8\uff08\u4f4e\uff09\u3002\u53ef\u7528\u4e8e\u5224\u65ad\u540c\u4e00k\u503c\u4e0b\u4ee5\u53ca\u4e0d\u540ck\u503c\u4e4b\u95f4cluster-consensus value\u7684\u9ad8\u4f4e\u3002<\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.1925925925925926\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_aUtogZCbFibhad76jFwaF6bOYpUFZw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNogvTpxnLicb3CVh80kq0j6zmkfiaUtogZCbFibhad76jFwaF6bOYpUFZw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: 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