{"id":58859,"date":"2024-06-16T23:42:46","date_gmt":"2024-06-16T15:42:46","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=58859"},"modified":"2024-06-16T23:42:46","modified_gmt":"2024-06-16T15:42:46","slug":"%e4%bd%a0%e7%bb%9d%e5%af%b9%e8%83%bd%e6%8b%bf%e4%b8%8b%e7%9a%84if-7%e7%9a%84%e6%96%b0%e6%80%9d%e8%b7%af%ef%bc%81%e5%ad%9f%e5%be%b7%e5%b0%94%e4%b8%8e%e8%8d%af%e9%9d%b6%e7%a0%94%e7%a9%b6%e6%96%b0","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=58859","title":{"rendered":"\u4f60\u7edd\u5bf9\u80fd\u62ff\u4e0b\u7684IF 7+\u7684\u65b0\u601d\u8def\uff01\u5b5f\u5fb7\u5c14\u4e0e\u836f\u9776\u7814\u7a76\u65b0\u7ed3\u5408\uff01\u8fd8\u6709\u836f\u7406\u5b66\u9a8c\u8bc1\u795e\u52a9\u653b\uff01\u56db\u5ddd\u5927\u5b66\u9648\u6c38\u5e73\u56e2\u961f\u73a9\u8f6c\u5b5f\u5fb7\u5c14\uff01\u5feb\u6765\uff01"},"content":{"rendered":"


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title=\"\u9605\u8bfb\u539f\u6587\" rel=\"noopener\">http:\/\/mp.weixin.qq.com\/s?__biz=Mzk0MDQ2MTU0Mg==&mid=2247494095&idx=1&sn=1f537e08ee8fc5e01422291fa7ec5c4c<\/a><\/p>\n<\/div>\n<p style=\"text-align: center;\" data-mpa-powered-by=\"yiban.io\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100017790\" data-ratio=\"0.25980392156862747\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_DNxb0KM6yCibvbKyMibDtACm6r56xg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAwicdLG9TCwxUpk4dYq9sClnZZeD1NY98ib9MVXUibzeoHiaXm0U3DNxb0KM6yCibvbKyMibDtACm6r56xg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"612\" style=\"\" data-recalc-dims=\"1\" \/><\/p>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316(MR)\u5e94\u7528\u9057\u4f20\u53d8\u5f02(\u5de5\u5177\u53d8\u91cf\uff0cIVs)\u6765\u7814\u7a76\u56e0\u679c\u5173\u7cfb\uff0c\u6bd4\u4f20\u7edf\u7684\u6d41\u884c\u75c5\u5b66\u65b9\u6cd5\u5177\u6709\u66f4\u5c11\u7684\u504f\u501a\uff0c\u56e0\u6b64\u5728\u8fd1\u51e0\u5e74\u7814\u7a76\u5341\u5206\u706b\u70ed\u3002\u672c\u6587\u4e5f\u662f\u4ece\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u51fa\u53d1\uff0c\u518d\u52a0\u4e0a\u836f\u7406\u5b66\u9a8c\u8bc1\uff0c\u4e00\u4e3e\u62ff\u4e0b9\u5206\uff0b\u9ad8\u6c34\u5e73\u8bba\u6587\uff0c\u4e00\u8d77\u6765\u770b\u770b\u5427~<\/span><span style=\"text-indent: 0em;font-family: Calibri;font-size: 16px;\"> <\/span><\/span><o:p style=\"text-indent: 0em;font-family: Calibri;font-size: 16px;letter-spacing: 1px;\"><span style=\"letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 16px;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;\">1. \u4f7f\u7528<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 176, 240);font-weight: bold;\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316 (MR) \u65b9\u6cd5\u7814\u7a76ALS<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\uff1aMR\u662f\u4e00\u79cd\u5229\u7528\u9057\u4f20\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\u6765\u8bc4\u4f30\u56e0\u679c\u5173\u7cfb\u7684\u65b9\u6cd5\u3002\u672c\u7814\u7a76\u9996\u6b21\u4f7f\u7528MR\u65b9\u6cd5\u6765\u7814\u7a76ALS\uff08\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff09\u7684\u53d1\u75c5\u673a\u5236\u548c\u6f5c\u5728\u836f\u7269\u9776\u70b9\u3002<\/span><\/span><span style=\"font-family: Calibri;font-size: 16px;text-indent: 0em;\">    <\/span><\/span><o:p style=\"font-family: Calibri;font-size: 16px;letter-spacing: 1px;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 16px;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;\">2. \u7ed3\u5408<\/span><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 176, 240);font-weight: bold;\">eQTL\u548c\u836f\u7269\u9776\u70b9\u6570\u636e\u8fdb\u884c\u7b5b\u9009<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\uff1a\u7814\u7a76\u4eba\u5458\u5c06\u663e\u8457\u7684cis-eQTL\uff08\u8868\u8fbe\u91cf\u9057\u4f20\u8c03\u63a7\u4f4d\u70b9\uff09\u548c\u53ef\u836f\u7269\u9776\u70b9\u57fa\u56e0\u5217\u8868\u8fdb\u884c\u91cd\u53e0\u5206\u6790\uff0c\u7b5b\u9009\u51fa\u4e0eALS\u76f8\u5173\u7684\u6f5c\u5728\u836f\u7269\u9776\u70b9\u57fa\u56e0\u3002<\/span><\/span><span style=\"font-family: Calibri;font-size: 16px;text-indent: 0em;\">  <\/span><\/span><o:p style=\"font-family: Calibri;font-size: 16px;letter-spacing: 1px;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 16px;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;\">3. <\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 176, 240);font-weight: bold;\">\u9a8c\u8bc1\u7ed3\u679c\u7684\u53ef\u9760\u6027<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\uff1a\u4e3a\u4e86\u589e\u52a0\u7ed3\u679c\u7684\u53ef\u9760\u6027\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e0d\u540c\u7684SNP\u9009\u62e9\u53c2\u6570\u548c\u989d\u5916\u7684\u8840\u6db2\u3001\u8111\u90e8\u548c\u810a\u9ad3\u6570\u636e\u5e93\u8fdb\u884c\u9a8c\u8bc1\uff0c\u786e\u8ba4\u4e86TBK1\u3001TNFSF12\u3001RESP18\u548cGPX3\u5728ALS\u4e2d\u7684\u4f5c\u7528\u3002<\/span><\/span><span style=\"font-family: Calibri;font-size: 16px;text-indent: 0em;\">     <\/span><\/span><o:p style=\"font-family: Calibri;font-size: 16px;letter-spacing: 1px;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 16px;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;\">4. <\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 176, 240);font-weight: bold;\">\u63d0\u4f9b\u6f5c\u5728\u7684\u836f\u7269\u9776\u70b9\u5217\u8868<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\uff1a\u7814\u7a76\u4eba\u5458\u603b\u7ed3\u4e86\u6f5c\u5728\u7684\u53ef\u836f\u7269\u9776\u70b9\u57fa\u56e0\u5217\u8868\uff0c\u5e76\u6839\u636e\u8fd9\u4e9b\u57fa\u56e0\u7684MR\u7ed3\u679c\u7ed8\u5236\u4e86\u56fe\u8868\uff0c\u4e3a\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u548c\u836f\u7269\u5f00\u53d1\u63d0\u4f9b\u4e86\u5019\u9009\u9776\u70b9\u3002<\/span><\/span><span style=\"font-family: Calibri;font-size: 16px;text-indent: 0em;\">         <\/span><\/span><o:p style=\"font-family: Calibri;font-size: 16px;letter-spacing: 1px;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u603b\u4e4b\uff0c\u8fd9\u7bc7\u6587\u7ae0\u901a\u8fc7\u521b\u65b0\u7684\u7814\u7a76\u65b9\u6cd5\u548c\u7b5b\u9009\u7b56\u7565\uff0c\u63ed\u793a\u4e86\u4e0eALS\u76f8\u5173\u7684\u6f5c\u5728\u836f\u7269\u9776\u70b9\uff0c\u5e76\u4e3a\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u548c\u6cbb\u7597\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u7ebf\u7d22\u3002\uff08<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(255, 0, 0);font-weight: bold;background: rgb(255, 255, 0);\">\u5404\u4f4d\u5c0f\u4f19\u4f34\u4eec\uff0c\u53d1\u8868\u5230MR\u6587\u7ae0\u53ef\u8c13\u662f\u6253\u5f00\u4e86\u5168\u65b0\u7684\u673a\u9047\u4e4b\u95e8\u554a\uff01MR\u5982\u4eca\u5df2\u7ecf\u201c\u706b\u7206\u5168\u573a\u201d\u60f3\u8981\u5148\u4eba\u4e00\u6b65\uff1f\u90a3\u5c31\u5fc5\u987b\u53ca\u65e9\u52a0\u5165\u6218\u5c40\uff0c\u65e0\u8bba\u662f\u521b\u65b0\u601d\u8def\u8fd8\u662f\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\uff0c\u5c0f\u9014\u90fd\u80fd\u5e2e\u4f60\u767b\u9876\uff0c\u671f\u5f85\u7740\u4f60\u7684\u9ad8\u6c34\u5e73\u8bba\u6587\uff01\uff09<\/span>  <\/span><\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017774\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-58.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 215px;height: 215px;\" data-recalc-dims=\"1\" \/><\/p>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010421\" data-ratio=\"0.512962962962963\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_TiaKAtL4unvcgcuA117YicbCLicFZA.png?resize=553%2C283\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQZX9YFIwA9plmG4JbpfdgOSAAfU5DiaicfmicbWLZdEg3oYpSZ8yTiaKAtL4unvcgcuA117YicbCLicFZA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"283 .60003662109375\" width=\"553 .010009765625\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(238, 130, 47);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u9898\u76ee\uff1a\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u5bf9\u8d25\u8840\u75c7\u548c\u8d25\u8840\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u56e0\u679c\u5f71\u54cd:\u6765\u81ea\u5168\u57fa\u56e0\u7ec4\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u3001\u5355\u7ec6\u80deRNA\u3001\u6574\u4f53<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">RNA\u6d4b\u5e8f\u548c\u7f51\u7edc\u836f\u7406\u5b66\u7684\u89c1\u89e3<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(238, 130, 47);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6742\u5fd7\uff1aJournal of Translational Medicine<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(238, 130, 47);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=7.4<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(238, 130, 47);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u53d1\u8868\u65f6\u95f4\uff1a202<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">4<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5e74<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">1<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6708<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><span style=\"font-weight: 700;text-indent: -28px;background-color: rgb(255, 255, 255);color: rgb(0, 82, 255);font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;outline: 0px;\"><\/span><\/span><\/section>\n<section style=\"text-align: center;direction: ltr;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u7814\u7a76\u80cc\u666f<\/span><\/section>\n<section style=\"text-align: justify;direction: ltr;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u8fd9\u7bc7\u6587\u7ae0\u7684\u7814\u7a76\u80cc\u666f\u662f\u5173\u4e8e\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\uff08ALS\uff09\u7684\u6cbb\u7597\u3002ALS\u662f\u4e00\u79cd\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u76ee\u524d\u5c1a\u65e0\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u4f7f\u7528MR\u65b9\u6cd5\uff0c\u63a2\u7d22\u4e0eALS\u76f8\u5173\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u3002\u901a\u8fc7\u5206\u6790\u5927\u89c4\u6a21\u57fa\u56e0\u7ec4\u6570\u636e\u548c\u4e34\u5e8a\u6570\u636e\uff0c\u786e\u5b9a\u4e86\u4e00\u4e2a\u4e0eALS\u98ce\u9669\u76f8\u5173\u7684\u57fa\u56e0TBK1\uff0c\u5e76\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86\u8be5\u57fa\u56e0\u7684\u529f\u80fd\u548c\u8c03\u63a7\u673a\u5236\u3002\u8fd9\u9879\u7814\u7a76\u4e3aALS\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u65b9\u5411\u548c\u6f5c\u5728\u7684\u836f\u7269\u9776\u70b9\uff0c\u5e0c\u671b\u89e3\u51b3\u9776\u70b9\u672a\u77e5\u673a\u7406\u4e0d\u660e\u6670\u7684\u95ee\u9898\u3002<\/span><\/section>\n<section style=\"direction: ltr;text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: center;direction: ltr;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6570\u636e\u6765\u6e90<\/span><\/section>\n<section style=\"text-align: justify;direction: ltr;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u8fd9\u7bc7\u6587\u7ae0\u7684\u6570\u636e\u6765\u6e90\u4e3b\u8981\u662f\u901a\u8fc7\u5b9e\u9a8c\u548c\u5206\u6790\u83b7\u5f97\u7684\u3002DNA\u4f4d\u7f6e\u5747\u57fa\u4e8e\u4eba\u7c7b\u53c2\u8003\u57fa\u56e0\u7ec4\u6784\u5efahg19 (GRCh37)\uff0c<\/span><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u8111\u7ec4\u7ec7\u7684\u987a\u5f0feQTL\u6570\u636e\u7531\u57fa\u56e0\u578b\u548c\u57fa\u56e0\u8868\u8fbe\u6570\u636e\u8fdb\u884c\uff0c\u6765\u81ea1387\u4e2a\u4e2a\u4f53\uff0c\u5305\u62ec679\u4e2a\u5065\u5eb7\u5bf9\u7167\u3001497\u4e2a\u7cbe\u795e\u5206\u88c2\u75c7\u3001172\u4e2a\u53cc\u76f8\u60c5\u611f\u969c\u788d\u300131\u4e2a\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u548c8\u4e2a\u60c5\u611f\u969c\u788d\u60a3\u8005<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;\">\u3002\u5b9e\u9a8c\u4e2d\u4f7f\u7528\u4e86\u591a\u79cd\u7ec6\u80de\u7cfb\u548c\u8bd5\u5242\uff0c\u5982NSC-34\u7ec6\u80de\u3001THP-1\u7ec6\u80de\u3001Dulbecco’s modified Eagle’s medium\uff08DMEM\uff09\u3001RPMI-1640\u57f9\u517b\u57fa\u7b49\u3002\u901a\u8fc7Western blotting\u548cRT-qPCR\u7b49\u6280\u672f\u5bf9\u86cb\u767d\u8d28\u8868\u8fbe\u6c34\u5e73\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002\u6b64\u5916\uff0c\u8fd8\u4f7f\u7528\u4e86\u7ec6\u80de\u6bd2\u6027\u6d4b\u8bd5\uff08CCK-8 assay\uff09\u6765\u8bc4\u4f30\u7ec6\u80de\u7684\u6bd2\u6027<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: center;direction: ltr;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u7814\u7a76\u601d\u8def<\/span><\/section>\n<section style=\"text-align: justify;direction: ltr;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;\">\u8fd9\u7bc7\u7814\u7a76\u7684\u4e3b\u8981\u601d\u8def\u662f\u901a\u8fc7\u5e94\u7528\u5b5f\u5fb7\u5c14\u968f\u673a\u5316 (MR)\u65b9\u6cd5\uff0c\u7ed3\u5408\u9057\u4f20\u53d8\u5f02\u548c\u57fa\u56e0\u8868\u8fbe\u6570\u636e\uff0c\u6765\u8bc6\u522b\u4e0e\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u76f8\u5173\u7684\u6f5c\u5728\u53ef\u836f\u7269\u9776\u70b9\u3002\u7814\u7a76\u9996\u5148\u6536\u96c6\u4e86\u4e0eALS\u76f8\u5173\u7684\u57fa\u56e0\u8868\u8fbe\u5b9a\u91cf\u6027\u72b6\u4f4d\u70b9\uff08cis-eQTL\uff09\u6570\u636e\uff0c\u5e76\u5c06\u5176\u4f5c\u4e3a\u4ee3\u7406\u53d8\u91cf\u6765\u5206\u6790\u6838\u82f7\u9178\u53d8\u5f02\u4e0e\u57fa\u56e0\u8868\u8fbe\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u7136\u540e\uff0c\u5229\u7528ALS\u7684\u57fa\u56e0\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u7ed3\u679c\uff0c\u901a\u8fc7MR\u5206\u6790\uff0c\u7b5b\u9009\u51fa\u4e0eALS\u98ce\u9669\u76f8\u5173\u7684\u6f5c\u5728\u53ef\u836f\u7269\u9776\u70b9\u3002\u63a5\u4e0b\u6765\uff0c\u901a\u8fc7\u8fdb\u4e00\u6b65\u7684\u5171\u5b9a\u4f4d\u5206\u6790\uff0c\u786e\u5b9a\u4e86\u4e0eALS\u98ce\u9669\u66f4\u5f3a\u76f8\u5173\u7684\u9776\u70b9\u57fa\u56e0\uff0c\u5305\u62ecTBK1\u3001TNFSF12\u3001RESP18\u548cGPX3\u3002\u6700\u540e\uff0c\u7814\u7a76\u901a\u8fc7\u4e00\u7cfb\u5217\u7684\u7b5b\u9009\u6807\u51c6\uff0c\u8bc6\u522b\u51fa\u4e0e\u8fd9\u4e9b\u9776\u70b9\u57fa\u56e0\u76f8\u5173\u7684\u5df2\u6709\u836f\u7269\uff0c\u5982R788\u548cAMX\uff0c\u5e76\u5728ALS\u7ec6\u80de\u6a21\u578b\u4e2d\u9a8c\u8bc1\u4e86\u8fd9\u4e9b\u836f\u7269\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u6574\u4e2a\u7814\u7a76\u7684\u76ee\u6807\u662f\u4e3aALS\u7684\u836f\u7269\u5f00\u53d1\u63d0\u4f9b\u6f5c\u5728\u7684\u9776\u70b9\u548c\u836f\u7269\u5019\u9009\uff0c\u5e76\u4e3a\u8fdb\u4e00\u6b65\u7684\u4e34\u5e8a\u5e94\u7528\u63d0\u4f9b\u57fa\u7840\u3002<\/span><\/section>\n<section style=\"text-align: center;direction: ltr;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010423\" data-ratio=\"0.562037037037037\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_uLNEbqRkEvrNXQXfMboq788BsVNh7g.png?resize=553%2C310\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQZX9YFIwA9plmG4JbpfdgOm7icAltMen0sSKgdrE8UeGO07uLNEbqRkEvrNXQXfMboq788BsVNh7g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"310 .79998779296875\" width=\"553 .2100219726562\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: justify;direction: ltr;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: center;direction: ltr;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u4e3b\u8981\u7ed3\u679c<\/span><\/section>\n<section style=\"text-align: justify;direction: ltr;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">  \u00b7\u57fa\u56e0\u8868\u8fbe\u4e0eALS\u9884\u540e\u7684MR\u5206\u6790<\/span><\/section>\n<section style=\"text-align: justify;direction: ltr;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;\">\u5c06\u663e\u8457\u987a\u5f0f- 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style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;\">MR\u5206\u6790\u7ed3\u679c\u663e\u793a\u542b\u67092\u4e2a\u4ee5\u4e0aSNPs\u7684\u57fa\u56e0IVs\u4ec5\u5b58\u5728\u4e8e\u8840\u6db2\u4e2d\uff0c\u4f5c\u8005\u5bf9\u8fd9\u4e9b\u57fa\u56e0\u8fdb\u884c\u4e86\u654f\u611f\u6027\u5206\u6790\u3002\u654f\u611f\u6027\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u9664STK32C\u3001PXDN\u3001PAM\u3001CD93\u548cSIRPB1\u5916\uff0c\u6240\u6709snp\u5927\u4e8e2\u7684\u57fa\u56e0\u5747\u901a\u8fc7MR-Egger\u548c\u52a0\u6743\u4e2d\u4f4d\u6570\u6cd5\u68c0\u6d4b(P < 0.05)\u3002<\/span><\/span><\/section>\n<section style=\"text-align: center;direction: ltr;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010422\" data-ratio=\"0.5722222222222222\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_h1n6P4bw4zhGmxl5icapofLhlAbZHA.png?resize=553%2C316\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQZX9YFIwA9plmG4JbpfdgOiarTo6FgLIl1T8s2wOEvEdjT0Ph1n6P4bw4zhGmxl5icapofLhlAbZHA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"316 .6700439453125\" width=\"553 .010009765625\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u9ed1\u4f53;font-variant: normal;text-transform: none;\">\u56fe <\/span><span style=\"font-size: 16px;font-family: Arial;font-variant: normal;text-transform: none;\">1<\/span><span style=\"font-size: 16px;font-family: \u9ed1\u4f53;font-variant: normal;text-transform: none;\">\u6f5c\u5728\u836f\u7269\u57fa\u56e0\u7684MR\u548c\u5171\u5b9a\u4f4d\u7ed3\u679c<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u00b7\u53d1\u73b0\u91cd\u65b0\u5229\u7528\u7684\u836f\u7269<\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;\">\u4f5c\u8005\u83b7\u5f97\u4e865\u79cd\u4f5c\u7528\u4e8e3\u4e2aals\u76f8\u5173\u57fa\u56e0\u9776\u70b9\u7684\u836f\u7269\uff0c\u5206\u522b\u662fTBK1\u3001TNFSF12\u548cGPX3(\u88681)\u3002\u6839\u636e\u4f5c\u8005\u7684\u7eb3\u5165\u6807\u51c6\uff0c\u5019\u9009\u836f\u7269\u5206\u4e3a3\u4e2a\u5c42\u6b21:\u8c37\u80f1\u7518\u80bd\u662f\u4e00\u79cd\u53c2\u4e0e\u591a\u79cd\u751f\u7406\u548c\u75c5\u7406\u72b6\u6001\u7684\u4e09\u80bd\u3002\u867d\u7136\u8c37\u80f1\u7518\u80bd\u53ef\u80fd\u62ee\u6297GPX3\u7f3a\u4e4f\u75c7\u5f15\u8d77\u7684\u795e\u7ecf\u6c27\u5316\u5e94\u6fc0\u53cd\u5e94\uff0c\u4f46\u7531\u4e8e\u5176\u5e7f\u8c31\u4f5c\u7528\uff0c\u4f5c\u8005\u5c06\u5176\u6392\u9664\u5728\u521d\u7ea7\u9009\u62e9(\u4e00\u7ea7)\u4e4b\u5916\u3002BIIB023\u548cRG7212\u90fd\u662f\u6297tnfsf12\u6297\u4f53\uff0c\u53ef\u80fd\u8c03\u8282\u795e\u7ecf\u5143\u548c\u80bf\u7624\u7ec4\u7ec7\u7684\u708e\u75c7\u8fc7\u7a0b\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u7814\u7a76(BIIB023\u7684\u6807\u8bc6\u53f7NCT01407406\u548cRG7212\u7684\u6807\u8bc6\u53f7NCT01383733)\u3002<\/span><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;\">\u7531\u4e8e\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u4e0d\u786e\u5b9a\uff0c\u8fd9\u4e24\u79cd\u751f\u7269\u5236\u5242\u672a\u80fd\u901a\u8fc7\u4e8c\u7ea7\u7b5b\u9009\u3002AMX\u662ffda\u6279\u51c6\u7684TBK1\u6291\u5236\u5242\uff0c\u800cR788\u662ffda\u6279\u51c6\u7684SYK\u6291\u5236\u5242\uff0c\u4e0eTBK1\u5177\u6709\u9ad8\u4eb2\u548c\u529b\u3002<\/span><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010420\" data-ratio=\"0.5326192794547225\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_9ELHt24Iop5B3Cc3iaVMbDvaM8Zt8Q.png?resize=491%2C261\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQZX9YFIwA9plmG4JbpfdgOiadhbTubkHz4RoticXx4QYPyMvy9ELHt24Iop5B3Cc3iaVMbDvaM8Zt8Q\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1027\" height=\"261 .8699951171875\" width=\"491 .6099853515625\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u9ed1\u4f53;font-variant: normal;text-transform: none;\">\u56fe <\/span><span style=\"font-size: 16px;font-family: Arial;font-variant: normal;text-transform: none;\">2 3\u4e2aALS\u53ef\u836f\u7269\u57fa\u56e0\u9776\u70b9\u548c5\u4e2a\u73b0\u6709\u836f\u7269\u88ab\u786e\u5b9a\u4e3a\u836f\u7269\u518d\u5229\u7528\u5e94\u7528<\/span><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u00b7AMX\u548cR788\u4f5c\u4e3aTBK1\u6291\u5236\u5242\u7684\u9274\u5b9a<\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;\">R788\u5728\u4f53\u5185\u53ef\u5feb\u901f\u8f6c\u5316\u4e3aR406\uff0c\u800c\u5176\u5728\u7ec6\u80de\u5b9e\u9a8c\u4e2d\u7684\u4ee3\u8c22\u8fc7\u7a0b\u5c1a\u4e0d\u6e05\u695a\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u5355\u72ec\u7684\u5206\u5b50\u5bf9\u63a5\u6a21\u62df\uff0c\u4ee5\u7814\u7a76TBK1\u4e0e\u6bcf\u79cd\u5316\u5b66\u7269\u8d28\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u4f5c\u8005\u7684\u6570\u636e\u663e\u793a\uff0c\u8fd9\u4e24\u79cd\u5316\u5b66\u7269\u8d28\u90fd\u9002\u5408TBK1\u6fc0\u9176\u7ed3\u6784\u57df\uff0c\u5176\u4e2d\u81ea\u7531\u80fd\u5206\u522b\u4e3a- 9.4 kcal\/mol\u548c- 8.9 kcal\/mol(\u56fe3)\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cR406\u4e0eTBK1\u76846\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u5f62\u6210\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\uff0c\u5176\u4e2d5\u4e2a(Ser93\u3001Leu15\u3001Gly139\u3001Asn140\u3001Asp157)\u88ab\u53d1\u73b0\u4f4d\u4e8e\u5e26\u6ce8\u91ca\u7684atp\u7ed3\u5408\u4f4d\u70b9\u6216atp\u888b\u5185(\u56fe3E)\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u9884\u6d4b\u7684R788-TBK1\u76f8\u4e92\u4f5c\u7528\u663e\u793a\u51fa\u6c22\u952e(\u4e0eSer93\u3001Thr96\u3001Leu15\u3001Gly18\u3001Ala21\u3001Asp157\u3001Thr156\u3001Lys137)\u3001\u758f\u6c34\u76f8\u4e92\u4f5c\u7528(\u4e0eLys137\u3001Asp157)\u3001\u5364\u7d20\u952e(\u4e0eThr156)\u548c\u76d0\u6865(\u4e0eLys38)\u3002\u5176\u4e2d\uff0c6\u4e2a\u6c28\u57fa\u9178(Ser93\u3001Leu15\u3001Gly18\u3001Ala21\u3001Lys38\u3001Asp157)\u4f4d\u4e8e\u540c\u4e00\u57fa\u5e8f\u4e2d(\u56fe3)\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660eTBK1\u4e0eR788\u6216R406\u4e4b\u95f4\u5177\u6709\u9ad8\u5ea6\u7684\u76f8\u4e92\u4f5c\u7528\u4eb2\u548c\u6027\uff0c\u5c3d\u7ba1\u5728CETSA\u5b9e\u9a8c\u4e2d\u6ca1\u6709\u53d1\u73b0TBK1\u5728R788\u540e\u7684\u70ed\u7a33\u5b9a\u6027\u53d1\u751f\u660e\u663e\u53d8\u5316\u3002<\/span><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 16px;\">    <\/span><span style=\"font-family: Calibri;font-size: 16px;text-indent: 0em;\">    <\/span><\/span><o:p style=\"font-family: Calibri;font-size: 16px;letter-spacing: 1px;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010424\" data-ratio=\"0.23425925925925925\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_JicAal6bCONwibEU2V7WjofDlnD7pA.png?resize=553%2C129\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQZX9YFIwA9plmG4JbpfdgOc9e1D5LIiav0TEzJj70oxWLof8vJicAal6bCONwibEU2V7WjofDlnD7pA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"129 .66998291015625\" width=\"553 .47998046875\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u9ed1\u4f53;font-variant: normal;text-transform: none;\">\u56fe <\/span><span style=\"font-size: 16px;font-family: Arial;font-variant: normal;text-transform: none;\">3SYK\u4e0eTBK1\u6fc0\u9176\u7ed3\u6784\u57df\u6c28\u57fa\u9178\u5e8f\u5217\u6bd4\u8f83<\/span><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u00b7R788\u548cAMX\u6291\u5236MSA-2\u8bf1\u5bfc\u7684cGAS\/STING\u6fc0\u6d3b<\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;\">\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0cAMX\u4e0eTBK1\u7684\u94f0\u94fe\u533a\u7ed3\u5408\uff0c\u5728\u4ecb\u5bfcTBK1\u548cIKK\u03b5\u7684\u9176\u6d3b\u6027\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002\u4f5c\u8005\u91c7\u7528\u7ec6\u80de\u70ed\u79fb\u6d4b\u5b9a(CETSA)\u6765\u7814\u7a76\u8fd9\u4e24\u79cd\u5316\u5b66\u7269\u8d28\u5bf9TBK1\u70ed\u7a33\u5b9a\u6027\u7684\u5f71\u54cd\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5bf9\u7167\u76f8\u6bd4\uff0c\u572837-60\u00b0C\u7684\u6e29\u5ea6\u8303\u56f4\u5185\uff0cAMX\u5bf9NSC-34\u7ec6\u80de\u88c2\u89e3\u7269\u4e2dTBK1\u70ed\u7a33\u5b9a\u6027\u7684\u5f71\u54cd\u8868\u73b0\u51fa\u4e2d\u7b49\u5dee\u5f02\u3002\u4f5c\u4e3a\u4e00\u79cdSYK\u6291\u5236\u5242\uff0cR788\u53ca\u5176\u6d3b\u6027\u5316\u5408\u7269R406\u5df2\u88ab\u8bc1\u5b9e\u4e0e\u4e00\u7cfb\u5217\u86cb\u767d\u6fc0\u9176\u9776\u70b9\u76f8\u4e92\u4f5c\u7528\uff0c\u5305\u62ecTBK1\u4e5f\u4e0eSYK\u7684\u7ed3\u5408\u4eb2\u548c\u529b(Kd = ~ 19 nM)\u76f8\u5f53\u3002\u5df2\u53d1\u8868\u7684\u5171\u6676\u7ed3\u6784\u8868\u660e\uff0cR406\u5d4c\u5165\u5728SYK\u6fc0\u9176\u7ed3\u6784\u57df\u5185\uff0c\u5360\u636eatp\u7ed3\u5408\u53e3\u888b\u3002\u5b83\u4e0e\u94f0\u94fe\u6b8b\u57faAla451\u5f62\u6210\u4e24\u4e2a\u6c22\u952e\uff0c\u82b3\u9999CH-O\u4e0eGlu449\u4e3b\u7fb0\u57fa\u76f8\u4e92\u4f5c\u7528\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e0a\u8ff0\u6240\u6709\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u6b8b\u57fa\u5728TBK1\u7684ATP\u53e3\u888b\u548cATP\u7ed3\u5408\u533a\u57df\u4e2d\u5b58\u5728\u7684\u5173\u952e\u6c28\u57fa\u9178\u5177\u6709\u76f8\u4f3c\u6027\u3002 <\/span><span style=\"letter-spacing: 1px;\"><span style=\"font-size: 16px;\">   <\/span><span style=\"font-family: Calibri;font-size: 16px;text-indent: 0em;\">   <\/span><\/span><o:p style=\"font-family: Calibri;font-size: 16px;letter-spacing: 1px;text-indent: 0em;\"><span style=\"letter-spacing: 1px;\"> <\/span><\/o:p><\/section>\n<section style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010427\" data-ratio=\"0.5451851851851852\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_9x9pcTkudjicGJmMAIkquL4HFghsXw.png?resize=540%2C294\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQZX9YFIwA9plmG4JbpfdgONQ5xMBuibica4dxqHfEbgkywUWJ9x9pcTkudjicGJmMAIkquL4HFghsXw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"675\" height=\"294 .39996337890625\" width=\"540 .010009765625\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u9ed1\u4f53;font-variant: normal;text-transform: none;\">\u56fe <\/span><span style=\"font-size: 16px;font-family: Arial;font-variant: normal;text-transform: none;\">4R406\u548cSYK\u901a\u8fc7\u5171\u6676\u7ed3\u6784(PDB: 3FQS)\u7684\u76f8\u4e92\u4f5c\u7528<\/span><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u00b7R788\u548cAMX\u6291\u5236ALS\u76f8\u5173\u6bd2\u6027\u86cb\u767d\u4ecb\u5bfc\u7684cGAS\/STING\u4fe1\u53f7\u4f20\u5bfc<\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;\">\u4f5c\u8005\u89c2\u5bdf\u5230\u8d28\u7c92\u8f6c\u67d3\u672c\u8eab\u7531\u4e8e\u5bf9\u7ec6\u80de\u6eb6\u8d28\u4e2d\u53d1\u751f\u7684\u8d28\u7c92DNA\u7684\u57fa\u7840cGAS\/STING\u5e94\u7b54\u800c\u89e6\u53d1TBK 1\u78f7\u9178\u5316\u3002\u6b64\u5916\uff0c\u5728\u7528SOD 1\u548cTDP 43\u76f8\u5173\u8d28\u7c92\u8f6c\u67d3\u7684\u7ec4\u4e2d\u4e5f\u89c2\u5bdf\u5230p-TBK 1\u7684\u8fdb\u4e00\u6b65\u589e\u52a0\uff0c\u8fd9\u8bc1\u5b9e\u4e86ALS\u6bd2\u6027\u86cb\u767d\u5bf9p-TBK 1\u7684\u8bf1\u5bfc\uff08\u56fe5\uff09\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u5e94\u7528\u5f3a\u529b\u9709\u7d20\u8bf1\u5bfc\u7cfb\u7edf\u5728NSC-34\u7ec6\u80de\u5185\u8868\u8fbeTDP 43<\/span><span style=\"letter-spacing: 1px;font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;\">\u548cQ331 K\u7a81\u53d8\u8d28\u7c92\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u8be5\u7cfb\u7edf\u4e2d\uff0cR788\u663e\u8457\u6291\u5236p-TBK 1\u548cp-IRF 3\u3002\u4f5c\u8005\u8fd8\u89c2\u5bdf\u5230AMX\u5904\u7406\u7ec4\u4e2dp-p65\u548cp-IRF 3\u964d\u4f4e\uff0c\u5176\u4e2dp-TBK 1\u662f\u5b8c\u6574\u7684\uff08\u56fe5 \uff09\u3002\u6b64\u5916\uff0cp65\u3001IRF 3\u548cIKK\u03b5\u7684\u603b\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\u4fdd\u6301\u4e0d\u53d8\u3002\u8fd9\u4e00\u53d1\u73b0\u4e0e\u62a5\u544a\u7684\u6291\u5236TBK 1\u548cIKK\u03b5\u7684\u53cc\u91cd\u7279\u5f02\u6027\u4e00\u81f4\u3002\u6b64\u5916\uff0cRT-qPCR\u6570\u636e\u8868\u660e\uff0cR788\u548cAMX\u6291\u5236\u4f5c\u8005\u5728\u8fc7\u5ea6\u8868\u8fbeTDP-43 WT\/Q331 K\u6216SOD 1 WT\/G93 A\u7684NSC-34\u7ec6\u80de\u4e2d\u6d4b\u8bd5\u7684\u6700\u4e0b\u6e38cGAS\/STING\u6548\u5e94\u7269\u7684\u8868\u8fbe\u3002\u4ec5\u5728TDP 43 Q331 K\u7a81\u53d8\u4f53\u4e2d\u89c2\u5bdf\u5230\u5bf9AMX\u7684TNFA\u8868\u8fbe\u7684\u660e\u663e\u6291\u5236\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u5176\u4ed6\u8f6c\u67d3\u5b50\u4e2d\u4e0d\u663e\u8457\u7684\u57fa\u56e0\u8868\u8fbe\u5dee\u5f02\u3002\u81f3\u4e8e\u53e6\u4e00\u79cd\u4e3b\u8981ALS\u76f8\u5173\u57fa\u56e0\u7684\u7ec6\u80de\u6a21\u578b\uff0cqPCR\u7ed3\u679c\u663e\u793a\uff0cR788\u6291\u5236\u8fc7\u8868\u8fbeC9 orf 72 GA 50\/PA 50\u7684NSC-34\u7ec6\u80de\u4e2dIFNB\u3001TNFA\u548cIL-6\u7684\u8868\u8fbe\uff0c\u800cAMX\u4ec5\u6291\u5236IFNB\u7684\u8868\u8fbe\u3002\u4e3a\u6b64\uff0c\u4f5c\u8005\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660eR788\u548cAMX\u5bf9\u67d0\u4e9bALS\u76f8\u5173\u795e\u7ecf\u708e\u75c7\u4e9a\u578b\u5177\u6709\u6f5c\u5728\u7684\u4fdd\u62a4\u4f5c\u7528\u3002 <\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">  <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010426\" data-ratio=\"0.5943502824858757\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_ialfAK4BHHy9xwTFa1ZGLOIkWCdDBQ.png?resize=386%2C229\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQZX9YFIwA9plmG4JbpfdgOVcqsNT9vEqHaRR6ibCReKNvq0jialfAK4BHHy9xwTFa1ZGLOIkWCdDBQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"885\" height=\"229 .39999389648438\" width=\"386 .26995849609375\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u9ed1\u4f53;font-variant: normal;text-transform: none;\">\u56fe <\/span><span style=\"font-size: 16px;font-family: Arial;font-variant: normal;text-transform: none;\">5 R788\u548cAMX\u6291\u5236\u7531TDP-43\/SOD 1\u8bf1\u5bfc\u7684cGAS\/STING\u4f9d\u8d56\u6027\u4fc3\u708e\u4fe1\u53f7\u4f20\u5bfc<\/span><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u00b7ALS\u65e2\u5f80\u53ef\u7528\u836f\u57fa\u56e0\u7684\u8868\u578b\u5168MR\u5206\u6790<\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;\">\u7531\u4e8e\u5927\u591a\u6570\u836f\u7269\u901a\u8fc7\u8840\u6db2\u5faa\u73af\u53d1\u6325\u4f5c\u7528\uff0c\u4f5c\u8005\u8bc4\u4f30\u4e86\u8840\u6db2\u4e2d\u7684TBK1\u9776\u5411\u836f\u7269\u5bf9\u5176\u4ed6\u9002\u5e94\u75c7\u662f\u5426\u6709\u6709\u76ca\u6216\u6709\u5bb3\u7684\u5f71\u54cd\u3002\u5728\u82f1\u56fd\u751f\u7269\u5e93\uff08SAIGE v.0.29\uff09\u4e2d\u5bf9783\u79cd\u975eALS\u75be\u75c5\u6216\u6027\u72b6\u8fdb\u884c\u4e86\u66f4\u5e7f\u6cdb\u7684MR\u7b5b\u67e5\uff0c\u7ed3\u679c\u663e\u793a\u4f7f\u7528Wald\u6bd4\u7387\u65b9\u6cd5\u672a\u53d1\u73b0\u663e\u8457\u76f8\u5173\u6027\uff08FDR < 0.05\uff09\uff0c\u8868\u660e\u8fd9\u4e9b\u836f\u7269\u662f\u5b89\u5168\u7684\u6216\u526f\u4f5c\u7528\u5f88\u5c11\u3002<\/span><\/section>\n<section style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010425\" data-ratio=\"0.4135593220338983\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_UlMoXOt8PQURUubggo0dEhE1qHR5Wg.png?resize=553%2C229\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LQZX9YFIwA9plmG4JbpfdgOydt6kMQqc9oKISvOhsWXJjEqUlMoXOt8PQURUubggo0dEhE1qHR5Wg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"885\" height=\"229 .0\" width=\"553 .6799926757812\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u9ed1\u4f53;font-variant: normal;text-transform: none;\">\u56fe <\/span><span style=\"font-size: 16px;font-family: Arial;font-variant: normal;text-transform: none;\">6R788\/AMX\u548ccGAS-STING\u9014\u5f84\u4e4b\u95f4\u7684\u4fe1\u53f7\u76f8\u4e92\u4f5c\u7528\u7684\u793a\u610f\u56fe<\/span><\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: center;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/section>\n<section style=\"text-align: justify;text-indent: 0em;margin-top: 8px;margin-bottom: 0px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;\">  <\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;\">\u672c\u6587\u7684\u7814\u7a76\u65e8\u5728\u901a\u8fc7\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\uff0c\u63a2\u7d22\u4e0e\u808c\u840e\u7f29\u6027\u4fa7\u7d22\u786c\u5316\u75c7 (ALS) \u76f8\u5173\u7684\u53ef\u836f\u7269\u9776\u70b9\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5728\u8840\u6db2\u548c\u5927\u8111\u4e2d\uff0c\u6709\u4e00\u4e9b\u57fa\u56e0\u8868\u8fbe\u4e0eALS\u98ce\u9669\u76f8\u5173\u3002\u5177\u4f53\u800c\u8a00\uff0c\u5728\u8840\u6db2\u4e2d\uff0cTNFSF13\u548cCD68\u7684\u8868\u8fbe\u4e0e\u964d\u4f4eALS\u98ce\u9669\u76f8\u5173\uff0c\u800cTNFSF12\u3001TBK1\u548cGPX3\u7684\u8868\u8fbe\u4e0e\u589e\u52a0ALS\u98ce\u9669\u76f8\u5173\u3002\u5728\u5927\u8111\u4e2d\uff0cRESP18\u7684\u8868\u8fbe\u4e0e\u589e\u52a0ALS\u98ce\u9669\u76f8\u5173\uff0c\u800cGDF9\u3001PTPRN\u548cGPX3\u7684\u8868\u8fbe\u4e0e\u964d\u4f4eALS\u98ce\u9669\u76f8\u5173\u3002\u800c\u8fd9\u4e9b\u7ed3\u679c\u7684\u4ea7\u751f\u5747\u901a\u8fc7\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u65b9\u6cd5\u5f97\u51fa\uff0c\u7531\u6b64\u53ef\u89c1\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u9488\u5bf9\u591a\u56e0\u7d20\u5206\u6790\u76f8\u5173\u7279\u5f81\u7684\u5f71\u54cd\u5341\u5206\u9760\u8c31\uff01\u8bd5\u60f3\u6362\u4e2a\u4e3b\u9898\uff0c\u540c\u4e2a\u601d\u8def\uff0c\u662f\u4e0d\u662f\u53c8\u6709\u4e00\u7bc7\u9ad8\u5206\u7814\u7a76\u56e0\u679c\u5173\u7cfb\u7684\u8bba\u6587\u51fa\u7089\u5462\uff1f<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(255, 0, 0);font-weight: bold;background: rgb(255, 255, 0);\">\uff08\u5c0f\u9014\u4e00\u76f4\u5728\u4e0d\u65ad\u63d0\u4f9b\u6700\u65b0\u7684\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u601d\u8def\uff0c\u4e3a\u60a8\u5e26\u6765\u524d\u6cbf\u79d1\u7814\u7684\u542f\u793a\uff01\u5982\u679c\u60a8\u5bf9\u8fd9\u4e9b\u601d\u8def\u611f\u5174\u8da3\uff0c\u5e76\u5e0c\u671b\u6df1\u5165\u63a2\u8ba8\u6216\u83b7\u53d6\u66f4\u591a\u521b\u65b0\u6027\u60f3\u6cd5\uff0c\u6b22\u8fce\u626b\u63cf\u4e0b\u65b9\u7684\u4e8c\u7ef4\u7801\uff0c\u4e0e\u5c0f\u9014\u8054\u7cfb\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u60a8\u4e00\u8d77\u63a2\u7d22\u79d1\u5b66\u7684\u8fb9\u754c\uff0c\u4eec\u643a\u624b\u5e76\u8fdb\uff0c\u5171\u540c\u8ffd\u6c42\u95ee\u9f0e\u9ad8\u6c34\u5e73\u8bba\u6587\uff01\uff09<\/span>    <\/span><\/section>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100017778\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_B2jkicacLzPjw4xMSqVvoucZjonVDA-58.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg'&from=appmsg\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100017513\" data-ratio=\"0.7621359223300971\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_XiafCUEp1NqZoBA3F9mvRcJR4PQ1Tw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAyZkFgOs95yxYHqY7n8a8k4wWKhXgwQvZVTwDhgYYDDu7asGXiafCUEp1NqZoBA3F9mvRcJR4PQ1Tw\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"618\" style=\"\" data-recalc-dims=\"1\" \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><br \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;margin-bottom: 0px;\"><br \/><\/p>\n<p style=\"display: none;margin-bottom: 24px;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4f60\u7edd\u5bf9\u80fd\u62ff\u4e0b\u7684IF 7+\u7684\u65b0\u601d\u8def\uff01\u5b5f\u5fb7\u5c14\u4e0e\u836f\u9776\u7814\u7a76\u65b0\u7ed3\u5408\uff01\u8fd8\u6709\u836f\u7406\u5b66\u9a8c\u8bc1\u795e\u52a9\u653b\uff01\u56db\u5ddd\u5927\u5b66\u9648\u6c38\u5e73\u56e2\u961f\u73a9\u8f6c\u5b5f\u5fb7\u5c14\uff01 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/58859"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=58859"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/58859\/revisions"}],"predecessor-version":[{"id":58871,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/58859\/revisions\/58871"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=58859"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=58859"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=58859"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}