{"id":58900,"date":"2024-06-16T23:45:05","date_gmt":"2024-06-16T15:45:05","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=58900"},"modified":"2024-06-16T23:45:05","modified_gmt":"2024-06-16T15:45:05","slug":"%e5%bd%93%e7%94%9f%e7%89%a9%e4%bf%a1%e6%81%af%e9%81%87%e4%b8%8a%e6%b7%b1%e5%ba%a6%e5%ad%a6%e4%b9%a0%ef%bc%8c%e4%bc%9a%e6%93%a6%e5%87%ba%e6%80%8e%e4%b9%88%e7%9a%84%e7%81%ab%e8%8a%b1%ef%bc%9f%e8%bf%99","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=58900","title":{"rendered":"\u5f53\u751f\u7269\u4fe1\u606f\u9047\u4e0a\u6df1\u5ea6\u5b66\u4e60\uff0c\u4f1a\u64e6\u51fa\u600e\u4e48\u7684\u706b\u82b1\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e26\u4f60\u611f\u53d7\u6df1\u5ea6\u5b66\u4e60\u7684\u9b45\u529b\uff01"},"content":{"rendered":"


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14px;\">\u9898\u76ee\uff1a\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u548c\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc\u786e\u5b9a\u4e86\u4e00\u4e2a\u65b0\u7684\u809d\u7ec6\u80de\u764c\u4e9a\u578b<o:p><\/o:p><\/span><\/p>\n<p><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;font-size: 14px;\">\u6742\u5fd7\uff1aCancer Biomarkers<o:p><\/o:p><\/span><\/p>\n<p><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;font-size: 14px;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=3.828<o:p><\/o:p><\/span><\/p>\n<p><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;font-size: 14px;\">\u53d1\u8868\u65f6\u95f4\uff1a2022\u5e749\u6708<\/span><\/p>\n<p><br \/><\/p>\n<\/section>\n<section style=\"font-size: 16px;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(32, 70, 126);border-width: 0px;border-radius: 30px;border-style: none;border-color: rgb(62, 62, 62);overflow: hidden;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(255, 255, 255);line-height: 1.8;letter-spacing: 5px;padding-right: 25px;padding-left: 25px;\">\n<p><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"font-size: 16px;\">\n<p><span style=\"font-size: 14px;\">\u5728\u4e16\u754c\u4e0a\u6700\u5e38\u89c1\u7684\u764c\u75c7\u4e2d\uff0c\u809d\u7ec6\u80de\u764c(HCC)\u6392\u540d\u7b2c\u4e94\uff0c\u4e5f\u662f\u5bfc\u81f4\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u4e09\u5927\u539f\u56e0\u4e4b\u4e00\u3002\u5728\u5317\u7f8e\u548c\u6b27\u6d32\uff0c\u8fd9\u4e9b\u5386\u53f2\u4e0a\u8f83\u4f4e\u7684HCC\u53d1\u75c5\u7387\u8fd1\u5e74\u6765\u6709\u6240\u589e\u52a0\u3002\u4e14\u7531\u4e8e\u75be\u75c5\u65e9\u671f\u7f3a\u4e4f\u7279\u5f02\u6027\u7279\u5f81\uff0c\u60a3\u8005\u901a\u5e38\u5728\u75be\u75c5\u8fdb\u5c55\u7684\u665a\u671f\u88ab\u8bca\u65ad\u51fa\u6765\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u4e00\u79cd\u51c6\u786e\u9884\u6d4bHCC\u60a3\u8005\u9884\u540e\u751f\u5b58\u98ce\u9669\u7684\u6a21\u578b\uff0c\u4ee5\u6307\u5bfc\u4e34\u5e8a\u6cbb\u7597\u3002<\/span><span style=\"font-family: "Times New Roman";font-size: 13px;\"><o:p><\/o:p><\/span><\/p>\n<p><span style=\"font-size: 14px;\"><br \/><\/span><\/p>\n<\/section>\n<section style=\"font-size: 16px;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(32, 70, 126);border-width: 0px;border-radius: 30px;border-style: none;border-color: rgb(62, 62, 62);overflow: hidden;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(255, 255, 255);line-height: 1.8;letter-spacing: 5px;padding-right: 25px;padding-left: 25px;\">\n<p><strong>\u6570\u636e\u6765\u6e90<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"font-size: 16px;\">\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.30453879941434847\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-08-07_\u5f53\u751f\u7269\u4fe1\u606f\u9047\u4e0a\u6df1\u5ea6\u5b66\u4e60\uff0c\u4f1a\u64e6\u51fa\u600e\u4e48\u7684\u706b\u82b1\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e26\u4f60\u611f\u53d7\u6df1\u5ea6\u5b66\u4e60\u7684\u9b45\u529b\uff01\/2_rx9TWU3zmEHORPyGvBY7M71uuyRglg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxkQdNGeWtDGfzAUzolwgtQDGbcHSVdicRnbUmsghRicgubzwrx9TWU3zmEHORPyGvBY7M71uuyRglg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"683\" style=\"\" \/><\/p>\n<p style=\"text-align: center;\"><br \/><\/p>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;font-size: 16px;\">\n<section style=\"margin-bottom: 10px;text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(32, 70, 126);border-width: 0px;border-radius: 30px;border-style: none;border-color: rgb(62, 62, 62);overflow: hidden;\">\n<section powered-by=\"xiumi.us\">\n<section style=\"padding-right: 25px;padding-left: 25px;color: rgb(255, 255, 255);line-height: 1.8;letter-spacing: 5px;\">\n<p><strong>\u7814\u7a76\u6d41\u7a0b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;font-size: 16px;\">\n<p><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u7b2c\u4e00\u6b65\u662f\u4eceTCGA-LIHC\u548cGSE112790\u4e24\u4e2a\u9879\u76ee\u4e2d\u9274\u5b9a\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u3002\u4f7f\u7528\u5355\u53d8\u91cfCOX\u548c\u591a\u53d8\u91cfCOX\u56de\u5f52\u5206\u6790\u6765\u8fdb\u4e00\u6b65\u8bc6\u522b\u4e0e\u751f\u5b58\u76f8\u5173\u7684\u57fa\u56e0\u3002\u5c06\u751f\u5b58\u76f8\u5173\u57fa\u56e0\u653e\u5165KMeans\u4e2d\u4ee5\u805a\u7c7b\u4e24\u79cd\u7c7b\u578b\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\u3002\u7136\u540e\u5206\u522b\u4f7f\u7528\u968f\u673a\u68ee\u6797\u548cLASSO\u56de\u5f52\u7b97\u6cd5\u6765\u5e2e\u52a9\u8bc6\u522b\u5f71\u54cd\u809d\u7ec6\u80de\u764c\u60a3\u8005\u9884\u540e\u7684\u5173\u952e\u57fa\u56e0\u3002\u5176\u6b21\uff0c\u901a\u8fc7\u4e00\u90e8\u5206\u6837\u672c\u8bad\u7ec3DNN\uff0c\u4f7f\u7528DNN\u4e0d\u719f\u6089\u7684\u53e6\u4e00\u90e8\u5206\u6570\u636e\u6765\u9884\u6d4b\u60a3\u8005\u7684\u4e9a\u578b\u3002\u6700\u7ec8\u4f7f\u7528Kaplan-Meier\u65b9\u6cd5\u6765\u8bc4\u4f30\u6548\u679c\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><br \/><\/span><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.7022900763358778\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-08-07_\u5f53\u751f\u7269\u4fe1\u606f\u9047\u4e0a\u6df1\u5ea6\u5b66\u4e60\uff0c\u4f1a\u64e6\u51fa\u600e\u4e48\u7684\u706b\u82b1\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e26\u4f60\u611f\u53d7\u6df1\u5ea6\u5b66\u4e60\u7684\u9b45\u529b\uff01\/3_OWrmS8z5kXpiaMU99yiarich683YCw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxkQdNGeWtDGfzAUzolwgtQRJ9iaemoHwcpVfgqRYaf9zLyJqX4OWrmS8z5kXpiaMU99yiarich683YCw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"655\" style=\"\" \/><\/p>\n<\/section>\n<p style=\"background: rgb(255, 255, 255);\"><br \/><\/p>\n<\/section>\n<section style=\"font-size: 16px;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(32, 70, 126);border-width: 0px;border-radius: 30px;border-style: none;border-color: rgb(62, 62, 62);overflow: hidden;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(255, 255, 255);line-height: 1.8;letter-spacing: 5px;padding-right: 25px;padding-left: 25px;\">\n<p><strong>\u4e3b\u8981\u7ed3\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;margin: 20px 0%;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(204, 223, 237);border-width: 0px;border-radius: 0px 50px 50px 0px;border-style: none;border-color: rgb(62, 62, 62);padding-right: 10px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row nowrap;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(60, 86, 125);border-width: 0px;border-radius: 0px 50px 50px 0px;border-style: none;border-color: rgb(62, 62, 62);\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;line-height: 2;padding-right: 15px;padding-left: 15px;\">\n<p><span style=\"font-size: 16px;\"><strong style=\"\"><span style=\"color: rgb(255, 255, 254);font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;letter-spacing: 2px;\">1.<\/span><\/strong><\/span><strong><span style=\"font-size: 12pt;letter-spacing: 0.034em;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;color: rgb(255, 255, 255);\">\u5dee\u5f02\u57fa\u56e0\u7684\u7b5b\u9009\u4e0e\u9274\u5b9a<\/span><\/strong><strong style=\"color: rgb(255, 255, 255);letter-spacing: 0.034em;\"><span style=\"font-family: "Microsoft YaHei UI";letter-spacing: 0.4pt;\"><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"font-size: 16px;\">\n<p><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;font-size: 14px;\">\u4f7f\u7528\u201cLimma\u201d\u5305\u5bf9GSE112790\u6570\u636e\u8fdb\u884c\u5dee\u5f02\u8868\u8fbe\u5206\u6790\uff0c\u7ed3\u679c\u5982\u56fe1(A)\u6240\u793a\uff0c\u83b7\u5f97624\u4e2a\u4e0b\u8c03\u57fa\u56e0\u548c794\u4e2a\u4e0a\u8c03\u57fa\u56e0\u3002\u540c\u65f6\u5bf9TCGA-LIHC\u6570\u636e\u8fdb\u884c\u5dee\u5f02\u8868\u8fbe\u5206\u6790\uff0c\u5982\u56fe1(B)\u6240\u793a\uff0c\u83b7\u5f97464\u4e2a\u4e0b\u8c03\u57fa\u56e0\u548c2394\u4e2a\u4e0a\u8c03\u57fa\u56e0\u3002\u4e14\u56fe1(C)\u5c55\u793a\u4e86\u6240\u6709\u7684\u5dee\u5f02\u57fa\u56e0\u70ed\u56fe\u3002\u4e14\u4ece\u4e24\u6b21\u5dee\u5f02\u5206\u6790\u4e2d\u6311\u9009\u4e86\u91cd\u53e0\u57fa\u56e0\uff0c\u5982\u56fe1(D)\u6240\u793a\u3002<\/span><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-family: "Times New Roman";color: rgb(255, 0, 0);font-size: 12pt;\"><o:p><\/o:p><\/span><\/span><\/p>\n<p style=\"background: rgb(255, 255, 255);\"><span style=\"mso-spacerun:"yes";font-family:"Microsoft YaHei UI";mso-bidi-font-family:\u5b8b\u4f53;color:rgb(51,51,51);letter-spacing:0.4000pt;font-size:11.0000pt;mso-font-kerning:0.0000pt;\"><o:p><\/o:p><\/span><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"1\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-08-07_\u5f53\u751f\u7269\u4fe1\u606f\u9047\u4e0a\u6df1\u5ea6\u5b66\u4e60\uff0c\u4f1a\u64e6\u51fa\u600e\u4e48\u7684\u706b\u82b1\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e26\u4f60\u611f\u53d7\u6df1\u5ea6\u5b66\u4e60\u7684\u9b45\u529b\uff01\/4_Zc61RKV6XaT08ib9S4PxuO4oiaJBwg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxkQdNGeWtDGfzAUzolwgtQYIgF5ShQFwTicyS5vyaRapo1HUhZc61RKV6XaT08ib9S4PxuO4oiaJBwg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"693\" style=\"\" \/><\/p>\n<p style=\"text-align: center;font-size: 16px;\"><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;color: rgb(136, 136, 136);font-size: 12px;\">\u56fe1 GSE112790\u548cTCGA-LIHC\u6570\u636e\u5dee\u5f02\u8868\u8fbe\u5206\u6790<\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: center;font-size: 16px;\"><br \/><\/p>\n<\/section>\n<section style=\"font-size: 16px;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;margin: 20px 0%;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(204, 223, 237);border-width: 0px;border-radius: 0px 50px 50px 0px;border-style: none;border-color: rgb(62, 62, 62);padding-right: 10px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row nowrap;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(60, 86, 125);border-width: 0px;border-radius: 0px 50px 50px 0px;border-style: none;border-color: rgb(62, 62, 62);\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;color: rgb(255, 255, 254);line-height: 2;letter-spacing: 2px;padding-right: 15px;padding-left: 15px;font-family: PingFangSC-light;font-size: 14px;\">\n<p><span style=\"font-size: 16px;\"><strong>2.<\/strong><\/span><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><strong><span style=\"font-size: 12pt;\">HCC<\/span><span style=\"font-size: 12pt;\">\u751f\u5b58\u76f8\u5173\u5173\u952e\u57fa\u56e0\u7684\u9009\u62e9<\/span><\/strong><\/span><strong><span style=\"font-size: 12pt;font-family: \u5b8b\u4f53;\"><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"font-size: 16px;\">\n<p><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u4f7f\u7528\u5355\u53d8\u91cfCOX\u56de\u5f52\u6a21\u578b\u6765\u68c0\u9a8c\u6bcf\u4e2a\u57fa\u56e0\u7684\u9884\u540e\u5f71\u54cd\u3002\u7b5b\u67e5\u9608\u503cp < 0.05\u7684\u57fa\u56e0\uff0c\u63d0\u793a\u5176\u9884\u540e\u6548\u679c\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u57fa\u4e8e\u5355\u56e0\u7d20COX\u7ed3\u679c\uff0c\u8fdb\u4e00\u6b65\u8003\u8651\u4e34\u5e8a\u56e0\u7d20\uff0c\u5305\u62ec\u6027\u522b\u3001\u5e74\u9f84\u3001T\u5206\u671f\u3001\u5206\u671f\u548c\u5206\u7ea7\u5206\u671f\u3002\u7136\u540e\u901a\u8fc7\u591a\u5143COX\u56de\u5f52\u8ba1\u7b97\u5404\u57fa\u56e0\u7684\u56de\u5f52\u7cfb\u6570\u3001\u98ce\u9669\u6bd4\u3001\u76f8\u5e94\u7684\u7f6e\u4fe1\u533a\u95f4\u548cp\u503c\u3002\u6700\u7ec8\u5f97\u5230\u4e86546\u4e2a\u7b26\u5408\u6761\u4ef6\u7684\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u3002<\/span><\/p>\n<p style=\"background: rgb(255, 255, 255);text-align: center;\"><br \/><\/p>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;font-size: 16px;letter-spacing: 0.578px;white-space: normal;\">\n<section style=\"margin-top: 20px;margin-bottom: 20px;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\">\n<section style=\"padding-right: 10px;display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(204, 223, 237);border-width: 0px;border-radius: 0px 50px 50px 0px;border-style: none;border-color: rgb(62, 62, 62);\">\n<section powered-by=\"xiumi.us\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row nowrap;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(60, 86, 125);border-width: 0px;border-radius: 0px 50px 50px 0px;border-style: none;border-color: rgb(62, 62, 62);\">\n<section powered-by=\"xiumi.us\">\n<section style=\"padding-right: 15px;padding-left: 15px;text-align: justify;color: rgb(255, 255, 254);line-height: 2;letter-spacing: 2px;font-family: PingFangSC-light;font-size: 14px;\">\n<p><span style=\"font-size: 16px;\"><strong>3.<\/strong><strong>\u57fa\u4e8e\u65e0\u76d1\u7763k\u5747\u503c\u805a\u7c7b\u7684\u4e24\u4e2a\u65b0\u4e9a\u578b<\/strong><\/span><strong style=\"color: rgb(255, 255, 255);font-size: 16px;\"><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"background: rgb(255, 255, 255);\"><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;font-size: 14px;letter-spacing: 0.034em;\">\u5f97\u5230\u751f\u5b58\u76f8\u5173\u7684\u5173\u952e\u57fa\u56e0\u540e\uff0c\u5229\u7528\u65e0\u76d1\u7763K-means\u8ddd\u79bb\u4e2d\u7684PAM\u51fd\u6570\u8ba1\u7b97\u4e0d\u540cK\u503c\u4e0b\u7684\u7c07\u95f4\u8f6e\u5ed3\u5bbd\u5ea6\uff0c\u5176\u805a\u7c7b\u6548\u679c\u5982\u56fe2(A)\u6240\u793a\u3002\u53ef\u4ee5\u770b\u5230\uff0c\u5f53K=2\u65f6\uff0cK-means\u6a21\u578b\u7684\u805a\u7c7b\u6548\u679c\u6700\u4f73\u3002\u5176\u7a7a\u95f4\u5206\u5e03\u5982\u56fe2(B)\u6240\u793a\u3002365\u4f8b\u60a3\u8005\u88ab\u5206\u4e3a\u4e24\u79cd\u65b0\u7684\u4e9a\u578b\u5305\u542b243\u4f8b\u4f4e\u5371\u60a3\u8005(C1)\u548c122\u4f8b\u9ad8\u5371\u60a3\u8005(C2)\u3002\u968f\u540e\u91c7\u7528Kaplan-Meier\u65b9\u6cd5\u5206\u6790\u4e24\u79cd\u4e9a\u578b\u7684\u751f\u5b58\u7387\uff0cK-M\u66f2\u7ebf\u5982\u56fe2(C)\u6240\u793a(p < 0.0001)\u3002\u8be5\u6a21\u578bROC\u66f2\u7ebf\u7684\u5177\u4f53\u53c2\u6570\u56fe2(D)\u3002\u6700\u540e\u6bd4\u8f83\u4e86\u4e24\u79cd\u4e9a\u578b\u4e2d\u4e0d\u540cAJCC\u5206\u7ea7\u60a3\u8005\u7684\u6bd4\u4f8b\uff0c\u7ed3\u679c\u5982\u56fe2(E)\u548c2(F)\u6240\u793a\uff0c\u53ef\u4ee5\u53d1\u73b0\u665a\u671f\u764c\u75c7\u60a3\u8005\u5728\u9ad8\u5371\u4e9a\u578b\u4e2d\u7684\u6bd4\u4f8b\u8fdc\u9ad8\u4e8e\u665a\u671f\u764c\u75c7\u60a3\u8005\u5728\u4f4e\u5371\u4e9a\u578b\u4e2d\u7684\u6bd4\u4f8b\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"1.170556552962298\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-08-07_\u5f53\u751f\u7269\u4fe1\u606f\u9047\u4e0a\u6df1\u5ea6\u5b66\u4e60\uff0c\u4f1a\u64e6\u51fa\u600e\u4e48\u7684\u706b\u82b1\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e26\u4f60\u611f\u53d7\u6df1\u5ea6\u5b66\u4e60\u7684\u9b45\u529b\uff01\/5_FPRIRZYznH5axbiaDVr82P2XhVzOyA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxkQdNGeWtDGfzAUzolwgtQoByeehVdpLDzNdkdMKaPLNDa0FPRIRZYznH5axbiaDVr82P2XhVzOyA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"557\" style=\"\" \/><\/p>\n<p style=\"text-align: center;font-size: 16px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u56fe2 \u65e0\u76d1\u7763K-means\u6a21\u578b\u805a\u7c7b\u5206\u6790<\/span><\/p>\n<p style=\"text-align: center;\"><br \/><\/p>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;font-size: 16px;letter-spacing: 0.578px;white-space: normal;\">\n<section style=\"margin-top: 20px;margin-bottom: 20px;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\">\n<section style=\"padding-right: 10px;display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(204, 223, 237);border-width: 0px;border-radius: 0px 50px 50px 0px;border-style: none;border-color: rgb(62, 62, 62);\">\n<section powered-by=\"xiumi.us\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row nowrap;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(60, 86, 125);border-width: 0px;border-radius: 0px 50px 50px 0px;border-style: none;border-color: rgb(62, 62, 62);\">\n<section powered-by=\"xiumi.us\">\n<section style=\"padding-right: 15px;padding-left: 15px;text-align: justify;color: rgb(255, 255, 254);line-height: 2;letter-spacing: 2px;font-family: PingFangSC-light;font-size: 14px;\">\n<p><span style=\"font-size: 16px;\"><strong>4<\/strong><\/span><span style=\"color: rgb(255, 255, 255);font-size: 16px;\"><strong>.<\/strong><\/span><strong><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><span style=\"font-size: 12pt;\">\u968f\u673a\u68ee\u6797\u548c<\/span><span style=\"font-size: 12pt;\">LASSO<\/span><span style=\"font-size: 12pt;\">\u964d\u7ef4<\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><span style=\"font-size: 14px;\">\u968f\u673a\u68ee\u6797\u6a21\u578b\u7684\u51b3\u7b56\u6811\u6570\u91cf\u53c2\u6570\uff08<\/span>ntree<span style=\"font-size: 14px;\">\uff09\u7531\u9519\u8bef\u6811\u56fe\u4f18\u5316\uff08\u56fe <\/span><span style=\"font-size: 14px;\">3A<\/span><span style=\"font-size: 14px;\">\uff09\uff0c<\/span><span style=\"font-size: 14px;\">\u201cmtry\u201d<\/span><span style=\"font-size: 14px;\">\u4f7f\u7528\u9ed8\u8ba4\u53c2\u6570\u3002\u8fd9\u6a21\u578b\u7684\u7279\u5f81\u5411\u91cf\u662f\u751f\u5b58\u76f8\u5173\u57fa\u56e0\uff0c\u5e76\u4e14\u7c7b\u522b\u5411\u91cf\u4f7f\u7528\u9ad8\u98ce\u9669\u548c\u4f4e\u98ce\u9669\u4e9a\u578b\u3002\u7ecf\u8fc7\u53cd\u590d\u8bad\u7ec3\uff0c\u6a21\u578b\u7684\u51fa\u888b\u8bef\u5dee\u7387\u4e3a<\/span><span style=\"font-size: 14px;\">4.66%<\/span><span style=\"font-size: 14px;\">\u3002\u5c06\u63a5\u8fd1\u5ea6\u77e9\u9635\u8f6c\u5316\u4e3a\u8ddd\u79bb\u77e9\u9635\uff0c\u8ba1\u7b97\u6bcf\u4e2a<\/span><span style=\"font-size: 14px;\">MDS<\/span><span style=\"font-size: 14px;\">\u8f74\u7684\u91cd\u8981\u6027\u3002\u4ece\u800c\u7ed8\u5236<\/span><span style=\"font-size: 14px;\">MDS<\/span><span style=\"font-size: 14px;\">\u56fe<\/span><span style=\"font-size: 14px;\">(<\/span><span style=\"font-size: 14px;\">\u56fe<\/span><span style=\"font-size: 14px;\">3B)<\/span><span style=\"font-size: 14px;\">\u3002\u9ad8\u5371\u548c\u4f4e\u5371\u60a3\u8005\u7684\u6837\u672c\u5206\u5e03\u5728<\/span><span style=\"font-size: 14px;\">MDS1<\/span><span style=\"font-size: 14px;\">\u8f74\u7684\u4e24\u7aef\uff0c\u76f8\u5e94\u7684<\/span><span style=\"font-size: 14px;\">ROC<\/span><span style=\"font-size: 14px;\">\u66f2\u7ebf<\/span><span style=\"font-size: 14px;\">(<\/span><span style=\"font-size: 14px;\">\u56fe<\/span><span style=\"font-size: 14px;\">3C)<\/span><span style=\"font-size: 14px;\">\u4e5f\u9a8c\u8bc1\u4e86\u968f\u673a\u68ee\u6797\u6a21\u578b\u7684\u53ef\u9760\u6027\u3002\u6839\u636e\u57fa\u5c3c\u7cfb\u6570\u4ece\u9ad8\u5230\u4f4e\u5bf9\u57fa\u56e0\u8fdb\u884c\u6392\u5e8f\uff0c\u8f93\u51fa\u6700\u91cd\u8981\u7684\u524d<\/span><span style=\"font-size: 14px;\">50<\/span><span style=\"font-size: 14px;\">\u4e2a\u57fa\u56e0<\/span><span style=\"font-size: 14px;\">(<\/span><span style=\"font-size: 14px;\">\u56fe<\/span><span style=\"font-size: 14px;\">3D)<\/span><span style=\"font-size: 14px;\">\u3002<\/span><o:p><\/o:p><\/span><\/p>\n<p><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><span style=\"font-size: 14px;\">\u4f7f\u7528<\/span>R<span style=\"font-size: 14px;\">\u5305<\/span>\u201cglmnet\u201d<span style=\"font-size: 14px;\">\u5b9e\u73b0<\/span>LASSO<span style=\"font-size: 14px;\">\u903b\u8f91\u56de\u5f52\uff0c\u65cf\u53c2\u6570\u8bbe\u7f6e\u4e3a<\/span>\u201c<span style=\"font-size: 14px;\">\u4e8c\u9879\u5f0f<\/span>\u201d<span style=\"font-size: 14px;\">\u3002\u4e0d\u65ad\u589e\u5927\u60e9\u7f5a<\/span>(Lambda)<span style=\"font-size: 14px;\">\uff0c\u4f7f\u6a21\u578b\u4e2d\u5404\u57fa\u56e0\u7684\u7cfb\u6570\u8c03\u6574\u4e3a\u8d8b\u4e8e<\/span>0<span style=\"font-size: 14px;\">\uff0c\u7cfb\u6570\u53ef\u89c6\u5316\u5982\u56fe<\/span>4A<span style=\"font-size: 14px;\">\u548c<\/span>4B<span style=\"font-size: 14px;\">\u6240\u793a\u3002\u4ea4\u53c9\u9a8c\u8bc1\u662f\u4f18\u5316\u6a21\u578b\u4ee5\u786e\u4fdd\u6a21\u578b\u7684\u5747\u65b9\u8bef\u5dee\u6ee1\u8db3\u8981\u6c42\u7684\u4e00\u4e2a\u5f88\u597d\u7684\u9009\u62e9<\/span>(<span style=\"font-size: 14px;\">\u56fe<\/span>4C)<span style=\"font-size: 14px;\">\u3002\u6bcf\u4e2a\u6a21\u578b\u5bf9\u5e94\u7684<\/span>ROC<span style=\"font-size: 14px;\">\u66f2\u7ebf\u4e0b\u9762\u79ef\u5b58\u50a8\u5728<\/span>AUC<span style=\"font-size: 14px;\">\u4e2d\u5e76\u8f93\u51fa<\/span>(<span style=\"font-size: 14px;\">\u56fe<\/span>4D)<span style=\"font-size: 14px;\">\uff0c\u5176\u4e2d<\/span>AUC<span style=\"font-size: 14px;\">\u503c\u5747\u5927\u4e8e<\/span>0.9<span style=\"font-size: 14px;\">\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"1.0389610389610389\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-08-07_\u5f53\u751f\u7269\u4fe1\u606f\u9047\u4e0a\u6df1\u5ea6\u5b66\u4e60\uff0c\u4f1a\u64e6\u51fa\u600e\u4e48\u7684\u706b\u82b1\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e26\u4f60\u611f\u53d7\u6df1\u5ea6\u5b66\u4e60\u7684\u9b45\u529b\uff01\/6_NDvHkTuEoF5TPoaF0IADpWS1njaQww.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxkQdNGeWtDGfzAUzolwgtQvRicqXHFz5BjM9qfbQYLaa33eNDvHkTuEoF5TPoaF0IADpWS1njaQww\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"693\" style=\"\" \/><\/p>\n<p style=\"text-align: center;font-size: 16px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u56fe3 \u968f\u673a\u68ee\u6797\u4e2d\u5019\u9009\u57fa\u56e0\u7684\u8bc6\u522b<\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.6782106782106783\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-08-07_\u5f53\u751f\u7269\u4fe1\u606f\u9047\u4e0a\u6df1\u5ea6\u5b66\u4e60\uff0c\u4f1a\u64e6\u51fa\u600e\u4e48\u7684\u706b\u82b1\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e26\u4f60\u611f\u53d7\u6df1\u5ea6\u5b66\u4e60\u7684\u9b45\u529b\uff01\/7_3KgFcprlb5gKGJFnqjUMhibmMNmNvQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxkQdNGeWtDGfzAUzolwgtQbc5NXelFUnzVPpMrpNL98AcB33KgFcprlb5gKGJFnqjUMhibmMNmNvQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"693\" style=\"\" \/><\/p>\n<p style=\"text-align: center;font-size: 16px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u56fe4 LASSO\u4e2d\u5019\u9009\u57fa\u56e0\u7684\u8bc6\u522b<\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: center;font-size: 16px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><br \/><\/span><\/p>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;font-size: 16px;letter-spacing: 0.578px;white-space: normal;\">\n<section style=\"margin-top: 20px;margin-bottom: 20px;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\">\n<section style=\"padding-right: 10px;display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(204, 223, 237);border-width: 0px;border-radius: 0px 50px 50px 0px;border-style: none;border-color: rgb(62, 62, 62);\">\n<section powered-by=\"xiumi.us\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row nowrap;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(60, 86, 125);border-width: 0px;border-radius: 0px 50px 50px 0px;border-style: none;border-color: rgb(62, 62, 62);\">\n<section powered-by=\"xiumi.us\">\n<section style=\"padding-right: 15px;padding-left: 15px;text-align: justify;line-height: 2;letter-spacing: 2px;font-size: 14px;\">\n<p><span style=\"font-size: 16px;\"><strong style=\"\"><span style=\"font-family:PingFangSC-light;\"><span style=\"color:#fffffe;\">5<\/span><span style=\"color:#ffffff;\">.<\/span><\/span><span style=\"font-family:Helvetica Neue, Helvetica, Hiragino Sans GB, Microsoft YaHei, Arial, sans-serif;color: rgb(255, 255, 255);\">DNN\u9884\u6d4b\u6a21\u578b\u7684\u5efa\u7acb<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><span style=\"font-size: 14px;\">\u5229\u7528<\/span><span style=\"font-size: 14px;\">Lasso<\/span><span style=\"font-size: 14px;\">\u6a21\u578b\u4e2d\u7cfb\u6570\u90e8\u4f4d<\/span><span style=\"font-size: 14px;\">0<\/span><span style=\"font-size: 14px;\">\u7684\u57fa\u56e0\u4e0e\u968f\u673a\u68ee\u6797\u7b5b\u9009\u7684<\/span><span style=\"font-size: 14px;\">T<\/span><\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">OP 50<\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><span style=\"font-size: 14px;\">\u57fa\u56e0\u8fdb\u884c\u6bd4\u8f83\uff0c\u6700\u540e\u5982\u56fe<\/span><span style=\"font-size: 14px;\">5(<\/span><\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">A)<\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><span style=\"font-size: 14px;\">\u6240\u793a\uff0c\u5f97\u5230<\/span><span style=\"font-size: 14px;\">1<\/span><\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">7<\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u4e2a\u57fa\u56e0\uff0c\u5c06\u8fd9<\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">17<span style=\"font-size: 14px;\">\u4e2a\u57fa\u56e0\u4f5c\u4e3a<\/span><span style=\"font-size: 14px;\">DNN<\/span><span style=\"font-size: 14px;\">\u6a21\u578b\u8bad\u7ec3\u7684\u7279\u5f81\u5411\u91cf\uff0c\u7c7b\u522b\u5411\u91cf\u4e3a\u65e0\u76d1\u7763\u805a\u7c7b\u5f97\u5230\u7684\u4e24<\/span><\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u7ec4\u4e9a\u578b\u3002\u5c06\u5177\u6709\u5b8c\u6574\u4e34\u5e8a\u6570\u636e\u7684<\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">TCGA-LIHC<span style=\"font-size: 14px;\">\u6570\u636e\u96c6\u968f\u673a<\/span><\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u5212\u5206\u4e09\u5206\u4e4b\u4e00\u4f5c\u4e3a\u6a21\u578b\u7684\u9884\u6d4b\u96c6\uff0c\u5176\u4f59\u4e09\u5206\u4e4b\u4e8c\u6837\u672c\u4f5c\u4e3a\u8bad\u7ec3\u96c6\u3002<span style=\"font-size: 14px;\">\u56fe<\/span><span style=\"font-size: 14px;\">5(<\/span><\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">C-F)<\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u5c55\u793a\u4e86\u8bad\u7ec3\u8fc7\u7a0b\u4e2d\u6570\u636e\u96c6\u7684\u4ea4\u53c9\u71b5\u635f\u5931\u3002\u5c06<\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">DNN<span style=\"font-size: 14px;\">\u9884\u6d4b\u7ed3\u679c\u548c<\/span><span style=\"font-size: 14px;\">K-Means<\/span><span style=\"font-size: 14px;\">\u805a\u7c7b\u7ed3\u679c\u653e\u5165\u6df7\u6dc6\u77e9\u9635<\/span><\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><span style=\"font-size: 14px;\">\u7ed3\u679c\u5982\u56fe<\/span><span style=\"font-size: 14px;\">5<\/span><\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">(B)<\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><span style=\"font-size: 14px;\">\u3002\u6700\u7ec8\u5c06\u9884\u6d4b\u96c6\u653e\u5165\u8bad\u7ec3\u5b8c\u6210\u7684<\/span><span style=\"font-size: 14px;\">K<\/span><\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">NN<\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><span style=\"font-size: 14px;\">\u6a21\u578b\uff0c\u5229\u7528\u9884\u6d4b\u7ed3\u679c\u7ed8\u5236\u751f\u5b58\u66f2\u7ebf\uff0c\u5982\u56fe<\/span><span style=\"font-size: 14px;\">5<\/span><\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">(G)<\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><span style=\"font-size: 14px;\">\u6240\u793a\uff0c\u53ef\u4ee5\u770b\u51fa\u8be5\u6a21\u578b\u53ef\u4ee5\u51c6\u786e\u9884\u6d4b\u60a3\u8005\u7684\u4e9a\u578b<\/span><span style=\"font-size: 14px;\">(p<\/span><\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">=0.00027)<\/span><span style=\"font-size: 14px;font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u3002<\/span><\/span><\/p>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;font-size: 16px;letter-spacing: 0.578px;white-space: normal;\">\n<section style=\"margin-top: 20px;margin-bottom: 20px;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;\">\n<section style=\"padding-right: 10px;display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(204, 223, 237);border-width: 0px;border-radius: 0px 50px 50px 0px;border-style: none;border-color: rgb(62, 62, 62);\">\n<section powered-by=\"xiumi.us\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row nowrap;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(60, 86, 125);border-width: 0px;border-radius: 0px 50px 50px 0px;border-style: none;border-color: rgb(62, 62, 62);\">\n<section powered-by=\"xiumi.us\">\n<section style=\"padding-right: 15px;padding-left: 15px;text-align: justify;line-height: 2;letter-spacing: 2px;font-size: 14px;\">\n<p><span style=\"font-size: 16px;\"><strong><span style=\"color:#fffffe;font-family: PingFangSC-light;\">6<\/span><span style=\"color: rgb(255, 255, 255);\"><span style=\"font-family:PingFangSC-light;\">.<\/span><span style=\"font-family:Helvetica Neue, Helvetica, Hiragino Sans GB, Microsoft YaHei, Arial, sans-serif;\">\u57fa\u56e0\u96c6\u5bcc\u96c6\u5206\u6790\u7ed3\u679c<\/span><\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;font-size: 14px;\">\u4f7f\u7528R\u5305\u201cenrichment go\u201d\u548c\u201cenrichment kegg\u201d\u5bf9\u5dee\u5f02\u57fa\u56e0\u8fdb\u884c\u8d85\u51e0\u4f55\u5206\u5e03\u68c0\u9a8c\u5206\u6790\u3002\u5982\u56fe6\u6240\u793a\u4e3aKEGG\u5bcc\u96c6\u5206\u6790\u7ed3\u679c\uff0c\u5982\u56fe7\u6240\u793a\u4e3aGO\u5bcc\u96c6\u5206\u6790\u7ed3\u679c\u3002\u4f7f\u7528MSigDB\u6570\u636e\u5e93\u4f5c\u4e3a\u80cc\u666f\u57fa\u56e0\u96c6\uff0c\u6765\u5c55\u5f00GSEA\u5206\u6790\u3002\u7ed3\u679c\u5982\u56fe8(A)\u548c8(B)\u5c55\u793a\u4e86\u4e0a\u8c03\u3001\u4e0b\u8c03\u57fa\u56e0\u6240\u5bcc\u96c6\u76848\u6761\u901a\u8def\u3002<span style=\"font-size: 14px;font-family: "Times New Roman";\"><o:p><\/o:p><\/span><\/span><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"1.4597364568081992\" data-s=\"300,640\" 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src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-08-07_\u5f53\u751f\u7269\u4fe1\u606f\u9047\u4e0a\u6df1\u5ea6\u5b66\u4e60\uff0c\u4f1a\u64e6\u51fa\u600e\u4e48\u7684\u706b\u82b1\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e26\u4f60\u611f\u53d7\u6df1\u5ea6\u5b66\u4e60\u7684\u9b45\u529b\uff01\/9_WueHnWwvATcicHkgOcPaRPCKhTWIbw.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxkQdNGeWtDGfzAUzolwgtQQ7IPrPz0GKMz32zaDKfSK2gLaWueHnWwvATcicHkgOcPaRPCKhTWIbw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"693\" style=\"\" \/><\/p>\n<p style=\"text-align: center;font-size: 16px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u56fe6  C1\u548cC2\u4e4b\u95f4\u7684KEGG\u901a\u8def\u5bcc\u96c6\u5206\u6790<\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.9206349206349206\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-08-07_\u5f53\u751f\u7269\u4fe1\u606f\u9047\u4e0a\u6df1\u5ea6\u5b66\u4e60\uff0c\u4f1a\u64e6\u51fa\u600e\u4e48\u7684\u706b\u82b1\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e26\u4f60\u611f\u53d7\u6df1\u5ea6\u5b66\u4e60\u7684\u9b45\u529b\uff01\/10_EVBklkRR4GMXDXhiaiaHd5avsI9gkA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxkQdNGeWtDGfzAUzolwgtQKDmRNTz17UicQ44BHgIp2VIPuWlEVBklkRR4GMXDXhiaiaHd5avsI9gkA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"693\" style=\"\" \/><\/p>\n<p style=\"text-align: center;font-size: 16px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u56fe7  \u57fa\u56e0\u672c\u4f53(GO)\u529f\u80fd\u5bcc\u96c6\u5206\u6790<\/span><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"1.1443001443001444\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2023-08-07_\u5f53\u751f\u7269\u4fe1\u606f\u9047\u4e0a\u6df1\u5ea6\u5b66\u4e60\uff0c\u4f1a\u64e6\u51fa\u600e\u4e48\u7684\u706b\u82b1\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5e26\u4f60\u611f\u53d7\u6df1\u5ea6\u5b66\u4e60\u7684\u9b45\u529b\uff01\/11_SGLlMLBgeCKMEkW1mg6CGE2hNTGiaQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxkQdNGeWtDGfzAUzolwgtQVkol4icCE7nguE7oic0hu0baHZfSGLlMLBgeCKMEkW1mg6CGE2hNTGiaQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"693\" style=\"\" \/><\/p>\n<p style=\"text-align: center;font-size: 16px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\">\u56fe8  GSEA\u5bcc\u96c6\u5206\u6790\u7ed3\u679c<\/span><span style=\"letter-spacing: 0.034em;\"><\/span><\/p>\n<p style=\"text-align: center;font-size: 16px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;\"><\/span><o:p><\/o:p><\/p>\n<p style=\"text-align: center;font-size: 16px;\"><span style=\"letter-spacing: 0.034em;\"><\/span><o:p><\/o:p><\/p>\n<\/section>\n<section style=\"font-size: 16px;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 10%;height: auto;background-color: rgb(32, 70, 126);border-width: 0px;border-radius: 30px;border-style: none;border-color: rgb(62, 62, 62);overflow: hidden;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(255, 255, 255);line-height: 1.8;letter-spacing: 5px;padding-right: 25px;padding-left: 25px;\">\n<p><strong>\u5c0f\u7ed3<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"background: rgb(255, 255, 255);\"><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;font-size: 14px;letter-spacing: 0.034em;\">\u8fd9\u7bc7\u6587\u7ae0\u4f7f\u7528\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u7b5b\u9009\u51fa<\/span><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;font-size: 14px;letter-spacing: 0.034em;\">17\u4e2aHCC\u60a3\u8005\u7684\u751f\u5b58\u76f8\u5173\u57fa\u56e0\uff0c\u5e76\u57fa\u4e8e\u8fd9\u4e9b\u57fa\u56e0\u8bad\u7ec3DNN\u6a21\u578b\u6765\u9884\u6d4bHCC\u60a3\u8005\u7684\u751f\u5b58\u98ce\u9669\u3002<\/span><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;font-size: 14px;letter-spacing: 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