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rgb(249, 172, 172) 0px 0px 5px 3px;\">\n<section style=\"text-align: center;transform: translate3d(2px, 0px, 0px);margin-top: -14px;margin-bottom: -14px;\" powered-by=\"xiumi.us\">\n<p>{ \u70b9\u51fb\u84dd\u5b57\uff0c\u5173\u6ce8\u6211\u4eec }<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5728\u751f\u7269\u4fe1\u606f\u5206\u6790\u7684\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4eec\u5e38\u5e38\u9700\u8981\u7528\u5230\u805a\u7c7b\u5206\u6790\uff0c\u4eca\u5929\u5c0f\u5e08\u59b9\u5c31\u7ed9\u5927\u5bb6\u5e26\u6765\u4e00\u4e2a\u805a\u7c7b\u795e\u5668ConsensusClusterPlus\uff5e<\/p>\n<p style=\"white-space: normal;\">ConsensusClusterPlus\u662f\u4e00\u4e2a\u57fa\u4e8e\u5171\u8bc6\u805a\u7c7b\uff08Consensus Clustering\uff09\u7684R\u5305\uff0c\u7528\u4e8e\u5bf9\u9ad8\u7ef4\u6570\u636e\u8fdb\u884c\u805a\u7c7b\u5206\u6790\u3002\u5171\u8bc6\u805a\u7c7b\u662f\u4e00\u79cd\u57fa\u4e8e\u91cd\u590d\u62bd\u6837\u7684\u805a\u7c7b\u65b9\u6cd5\uff0c\u5b83\u901a\u8fc7\u5bf9\u591a\u6b21\u968f\u673a\u62bd\u6837\u5f97\u5230\u7684\u6570\u636e\u5b50\u96c6\u8fdb\u884c\u805a\u7c7b\u5206\u6790\uff0c\u5e76\u5c06\u591a\u6b21\u805a\u7c7b\u7ed3\u679c\u8fdb\u884c\u6574\u5408\uff0c\u4ece\u800c\u5f97\u5230\u66f4\u52a0\u9c81\u68d2\u548c\u7a33\u5b9a\u7684\u805a\u7c7b\u7ed3\u679c\u3002<\/p>\n<p style=\"white-space: normal;\">ConsensusClusterPlus\u5305\u62e5\u6709\u591a\u79cd\u805a\u7c7b\u7b97\u6cd5\u9009\u9879\uff0c\u5305\u62eck-means\u3001hierarchical clustering\u3001PAM\u7b49\u3002\u8be5\u5305\u652f\u6301\u5728\u4e0d\u540c\u805a\u7c7b\u6570\uff08k\u503c\uff09\u4e0b\u8fd0\u884c\u5171\u8bc6\u805a\u7c7b\uff0c\u5e76\u4e14\u80fd\u591f\u81ea\u52a8\u9009\u62e9\u6700\u4f18\u7684\u805a\u7c7b\u6570\uff0c\u540c\u65f6\u8fd8\u63d0\u4f9b\u4e86\u53ef\u89c6\u5316\u5de5\u5177\uff0c\u4f8b\u5982\u8ddf\u8e2a\u56fe\u3001\u5171\u8bc6\u77e9\u9635\u7b49\uff0c\u65b9\u4fbf\u7528\u6237\u5bf9\u805a\u7c7b\u7ed3\u679c\u8fdb\u884c\u5206\u6790\u548c\u89e3\u91ca\u3002<\/p>\n<p style=\"white-space: normal;\">\u5728\u4f7f\u7528ConsensusClusterPlus\u65f6\uff0c\u9700\u8981\u8bbe\u7f6e\u4e00\u4e9b\u53c2\u6570\u4ee5\u83b7\u5f97\u6700\u4f73\u7684\u805a\u7c7b\u7ed3\u679c\u3002\u4e0b\u9762\u662fConsensusClusterPlus\u4e2d\u5e38\u7528\u7684\u53c2\u6570\u4ecb\u7ecd\uff1a<\/p>\n<p style=\"white-space: normal;\"><strong>d\uff1a<\/strong>\u8981\u805a\u7c7b\u7684\u6570\u636e\uff1b\u8981\u4e48\u662f\u4e00\u4e2a\u6570\u636e\u77e9\u9635\uff0c\u5176\u4e2d columns=items\/samples \u548c rows \u662f\u7279\u5f81\u3002\u4f8b\u5982\uff0c\u884c\u4e2d\u57fa\u56e0\u548c\u5217\u4e2d\u5fae\u9635\u5217\u7684\u57fa\u56e0\u8868\u8fbe\u77e9\u9635\uff0c\u6216 ExpressionSet \u5bf9\u8c61\uff0c\u6216\u8ddd\u79bb\u5bf9\u8c61\uff08\u4ec5\u9002\u7528\u4e8e\u6ca1\u6709\u7279\u5f81\u91cd\u91c7\u6837\u7684\u60c5\u51b5\uff09<\/p>\n<p style=\"white-space: normal;\"><strong>distance\uff1a<\/strong>\u8ddd\u79bb\u5ea6\u91cf\u65b9\u6cd5\uff0c\u53ef\u4ee5\u662f\u6b27\u51e0\u91cc\u5f97\u8ddd\u79bb\uff08”euclidean”\uff09\u3001\u76f8\u5173\u7cfb\u6570\uff08”correlation”\uff09\u3001\u76ae\u5c14\u900a\u76f8\u5173\u7cfb\u6570\uff08”pearson”\uff09\u7b49\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>maxK\uff1a<\/strong>\u805a\u7c7b\u6570\u8303\u56f4\uff0c\u6700\u5927\u805a\u7c7b\u6570\uff0c\u9700\u8981\u662f\u4e00\u4e2a\u6574\u6570\u503c\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>seed\uff1a<\/strong>\u4e3a\u53ef\u91cd\u73b0\u7684\u7ed3\u679c\u8bbe\u7f6e\u968f\u673a\u79cd\u5b50\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>reps\uff1a<\/strong>\u91cd\u590d\u6b21\u6570\uff0c\u8868\u793a\u5728\u6bcf\u4e2a\u805a\u7c7b\u6570\u4e0b\u8fdb\u884c\u7684\u968f\u673a\u62bd\u6837\u6b21\u6570\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>pItem\uff1a<\/strong>\u9879\u76ee\uff08\u5217\uff09\u7684\u5b50\u96c6\u5927\u5c0f\uff0c\u8868\u793a\u5728\u6bcf\u4e2a\u91cd\u590d\u4e2d\u8981\u62bd\u6837\u7684\u7279\u5f81\u6570\uff0c\u901a\u5e38\u8bbe\u7f6e\u4e3a\u6570\u636e\u96c6\u7684\u5e73\u65b9\u6839\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>clusterAlg\uff1a<\/strong>\u805a\u7c7b\u7b97\u6cd5\uff0c\u53ef\u4ee5\u662fk-means\uff08”km”\uff09\u3001hierarchical\uff08”hc”\uff09\u3001PAM\uff08”pam”\uff09\u7b49\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>pItemReplace\uff1a<\/strong>\u5728\u6bcf\u4e2a\u91cd\u590d\u4e2d\u662f\u5426\u66ff\u6362\u9009\u5b9a\u7684\u9879\u76ee\uff08\u5217\uff09\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>verbose\uff1a<\/strong>\u662f\u5426\u663e\u793a\u8fed\u4ee3\u8fc7\u7a0b\u7684\u8be6\u7ec6\u4fe1\u606f\uff0c\u5982\u679c\u4e3a TRUE\uff0c\u5219\u5c06\u6d88\u606f\u6253\u5370\u5230\u5c4f\u5e55\u4ee5\u6307\u793a\u8fdb\u5ea6\u3002\u8fd9\u5bf9\u4e8e\u5927\u578b\u6570\u636e\u96c6\u5f88\u6709\u7528\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>verbosePlot\uff1a<\/strong>\u662f\u5426\u663e\u793a\u7ed8\u56fe\u7684\u8be6\u7ec6\u4fe1\u606f\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>tmyPal\uff1a<\/strong>\u5171\u8bc6\u77e9\u9635\u7684\u53ef\u9009\u989c\u8272\u7279\u5f81\u5411\u91cf\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>ml\uff1a<\/strong>\u5148\u524d\u7684\u7ed3\u679c\uff0c\u5982\u679c\u63d0\u4f9b\u5219\u53ea\u505a\u56fe\u5f62\u548c\u8868\u683c\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>title\uff1a<\/strong>\u8f93\u51fa\u76ee\u5f55\u7684\u5b57\u7b26\u503c\u3002\u4ec5\u5f53 plot \u4e0d\u4e3a NULL \u6216 writeTable \u4e3a TRUE \u65f6\u624d\u521b\u5efa\u76ee\u5f55\u3002\u6b64\u6807\u9898\u53ef\u4ee5\u662f\u7edd\u5bf9\u8def\u5f84\u6216\u76f8\u5bf9\u8def\u5f84\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>plot\uff1a<\/strong>\u5b57\u7b26\u503c\u3002NULL – \u6253\u5370\u5230\u5c4f\u5e55\uff0c\u7528\u4e8e\u4f4d\u56fe png \u7684 ‘pdf’\u3001’png’\u3001’pngBMP’\uff0c\u6709\u52a9\u4e8e\u5927\u578b\u6570\u636e\u96c6\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>writeTable\uff1a<\/strong>TRUE – \u5c06\u8f93\u51fa\u548c\u65e5\u5fd7\u5199\u5165 csv\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>weightsItem\uff1a<\/strong>\u7528\u4e8e\u62bd\u6837\u9879\u76ee\u7684\u6743\u91cd\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>weightsFeature\uff1a<\/strong>\u7528\u4e8e\u62bd\u6837\u7279\u5f81\u7684\u6743\u91cd\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>res\uff1a<\/strong>consensusClusterPlus \u7684\u7ed3\u679c\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>innerLinkage\uff1a<\/strong>\u7528\u4e8e\u5b50\u91c7\u6837\u7684\u5206\u5c42\u94fe\u63a5\u65b9\u6cd5\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>finalLinkage\uff1a<\/strong>\u5171\u8bc6\u77e9\u9635\u7684\u5c42\u6b21\u94fe\u63a5\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u63a5\u4e0b\u6765\u5c31\u8ba9\u5c0f\u5e08\u59b9\u4ee5GEO\u6570\u636e\u5e93\u4e2d\u7684GSE10245\u6570\u636e\u96c6\u4e3a\u4f8b\u5e26\u4f60\u4f7f\u7528ConsensusClusterPlus\uff0c\u8be5\u6570\u636e\u96c6\u5305\u542b\u4e86\u4eba\u7c7b\u80ba\u764c\u7ec4\u7ec7\u548c\u6b63\u5e38\u80ba\u7ec4\u7ec7\u7684\u57fa\u56e0\u8868\u8fbe\u6570\u636e\u3002<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5bfc\u5165\u6570\u636e<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">library(GEOquery)<\/span><\/code><code><span class=\"code-snippet_outer\">gse <- getGEO(<span class=\"code-snippet__string\">\"GSE10245\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">data <- exprs(gse[[<span class=\"code-snippet__number\">1<\/span>]])<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6570\u636e\u9884\u5904\u7406\uff0c\u8fdb\u884c\u6570\u636e\u6807\u51c6\u5316<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">library(limma)<\/span><\/code><code><span class=\"code-snippet_outer\">data <- normalizeBetweenArrays(data, method=<span class=\"code-snippet__string\">\"quantile\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5bfc\u5165ConsensusClusterPlus\u5305\uff0c\u5bf9\u6570\u636e\u8fdb\u884c\u805a\u7c7b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">library(ConsensusClusterPlus)<\/span><\/code><code><span class=\"code-snippet_outer\">ccp <- ConsensusClusterPlus(data, maxK=<span class=\"code-snippet__number\">5<\/span>, reps=<span class=\"code-snippet__number\">100<\/span>, distance=<span class=\"code-snippet__string\">\"pearson\"<\/span>, clusterAlg=<span class=\"code-snippet__string\">\"km\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u63a5\u4e0b\u6765\u6211\u4eec\u5c31\u53ef\u4ee5\u5f97\u52308\u5f20\u805a\u7c7b\u7ed3\u679c\u7684\u56fe\u7247\uff0c\u5206\u522b\u662f\uff1a<br \/><\/p>\n<p style=\"white-space: normal;\">\u56db\u79cd\u5206\u7c7b\u7684\u4e00\u81f4\u6027\u77e9\u9635\u548c\u989c\u8272\u7684\u6807\u8bc6<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9241573033707865\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_dcxbeicsfPV0MZZAZicrrCmFVgxibg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNBcibXNksKj5nwUO369z32sEvGEp3dcxbeicsfPV0MZZAZicrrCmFVgxibg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"712\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.38996138996139\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_AB2xan4s43LkowtLwzOgF2F6eFGS6g-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNSDiaxm9soeGA5kfl74EmsprWcAB2xan4s43LkowtLwzOgF2F6eFGS6g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"518\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.320754716981132\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_P4pHyb64Kkvncuh0FyicgicYtdFicA-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNJrBJWRqgIq3DZ5vibtkUjvauxjwFP4pHyb64Kkvncuh0FyicgicYtdFicA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"530\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.193103448275862\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_FpXx1fpWNQibia2ib027SbqJTBaqCg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNK4G86A9OBZqJOUozrPIXpd59QvaFpXx1fpWNQibia2ib027SbqJTBaqCg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"580\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.2304964539007093\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_rC3TX3aHuOQpaayJ3K8JAQU4mT09dQ-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNFicjwFwsRvP0wVeLy04g34OKyrC3TX3aHuOQpaayJ3K8JAQU4mT09dQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"564\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"text-align: center;white-space: normal;\" powered-by=\"xiumi.us\"><span style=\"font-size: 12px;color: rgb(160, 160, 160);\">\u4e00\u81f4\u6027\u7d2f\u79ef\u5206\u5e03\u51fd\u6570\u56fe<\/span><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5805555555555556\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_jm4EPUn75v8lkWCwLQHCvfkvRScCxg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNhKypWqeia12SpPAuDlSGOrZAVjm4EPUn75v8lkWCwLQHCvfkvRScCxg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"text-align: center;white-space: normal;\" powered-by=\"xiumi.us\"><span style=\"font-size: 12px;color: rgb(160, 160, 160);\">\u788e\u77f3\u56fe<\/span><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6018518518518519\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_nFdaXZVBTGdRSAOguVicdbTUujIsWQ-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNmjcJibdcdJ3LeHpADVvscMAtRicnFdaXZVBTGdRSAOguVicdbTUujIsWQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"text-align: center;white-space: normal;\" powered-by=\"xiumi.us\"><span style=\"font-size: 12px;color: rgb(160, 160, 160);\">\u8ddf\u8e2a\u56fe<\/span><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6240740740740741\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_w8aA30ogwVBQnkic5mMo01K06MtxKQ-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNGq13yFCfqY9lWWia3ia0KagF21Uw8aA30ogwVBQnkic5mMo01K06MtxKQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u63a5\u4e0b\u6765\u4f7f\u7528calcICL\u51fd\u6570\u8ba1\u7b97\u805a\u7c7b\u4e00\u81f4\u6027\u548c\u6837\u54c1\u4e00\u81f4\u6027<br \/><\/p>\n<p style=\"white-space: normal;\">icl <- calcICL(ccp)<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5638888888888889\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_ArphGwdHdIB4aglgrISWGBsP3s0fhA-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNq6iavtW8SNHMkGKyZ5rDFSrOHArphGwdHdIB4aglgrISWGBsP3s0fhA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.18425925925925926\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_s2ktibslQxh75gE8UojUz8msMEpwVA-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNDQQkQoXX07fWMYcOMnnfq5o6Js2ktibslQxh75gE8UojUz8msMEpwVA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.1925925925925926\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_aUtogZCbFibhad76jFwaF6bOYpUFZw-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNogvTpxnLicb3CVh80kq0j6zmkfiaUtogZCbFibhad76jFwaF6bOYpUFZw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">ConsensusClusterPlus\u77ed\u77ed\u4e24\u884c\u4ee3\u7801\u5c31\u80fd\u5e26\u6765\u805a\u7c7b\u5206\u6790\u548c14\u5f20\u53ef\u89c6\u5316\u56fe\u7247\uff0c\u662f\u4e0d\u662f\u5f88\u795e\u5947\u5462\uff1f\u76f8\u4fe1\u4e5f\u6709\u8bb8\u591a\u5c0f\u4f19\u4f34\u5bf9\u8fd914\u5f20\u56fe\u7684\u611f\u5230\u56f0\u60d1\uff0c\u4e0b\u4e00\u671f\u5c0f\u5e08\u59b9\u5c06\u7ed9\u5927\u5bb6\u7ec6\u7ec6\u9053\u6765\u6bcf\u5f20\u56fe\u7684\u610f\u4e49\uff5e\u656c\u8bf7\u671f\u5f85\uff5e<\/p>\n<p style=\"white-space: normal;\">\u66f4\u591a\u5b9e\u7528\u65b9\u4fbf\u7684\u5c0f\u5de5\u5177\u5728\u4e91\u751f\u4fe1\u5e73\u53f0\u7b49\u7740\u4f60\u54e6<\/p>\n<p style=\"white-space: normal;\"><strong>http:\/\/www.biocloudservice.com\/home.html<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"letter-spacing: 0.578px;white-space: normal;font-size: 16px;margin-bottom: 24px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;\">\n<section style=\"margin-right: 10px;display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;height: auto;align-self: center;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"background-color: rgb(249, 172, 172);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"margin-right: 10px;padding-right: 8px;padding-left: 8px;display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;border-style: solid;border-width: 1px;border-color: rgb(249, 172, 172);\">\n<section powered-by=\"xiumi.us\" style=\"text-align: justify;color: rgb(249, 172, 172);\">\n<p>E<\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 10px;padding-right: 8px;padding-left: 8px;display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;border-style: solid;border-width: 1px;border-color: rgb(249, 172, 172);\">\n<section powered-by=\"xiumi.us\" style=\"text-align: justify;color: rgb(249, 172, 172);\">\n<p>N<\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 10px;padding-right: 8px;padding-left: 8px;display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;border-style: solid;border-width: 1px;border-color: rgb(249, 172, 172);\">\n<section powered-by=\"xiumi.us\" style=\"text-align: justify;color: rgb(249, 172, 172);\">\n<p>D<\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 100 100 0%;height: auto;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"background-color: rgb(249, 172, 172);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"letter-spacing: 0.578px;white-space: normal;text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.5555555555555556\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_icWAmgGMVEzREAJmM59ov44ziaMCGg-2.jpg?w=640\" 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{"id":59015,"date":"2024-06-17T07:23:12","date_gmt":"2024-06-16T23:23:12","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=59015"},"modified":"2024-06-17T07:23:12","modified_gmt":"2024-06-16T23:23:12","slug":"%e4%b8%a4%e8%a1%8c%e4%bb%a3%e7%a0%8110%e5%bc%a0%e5%9b%be%e7%9a%84%e8%81%9a%e7%b1%bb%e7%a5%9e%e5%99%a8consensusclusterplus%ef%bc%88%e4%b8%8a%ef%bc%89","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=59015","title":{"rendered":"\u4e24\u884c\u4ee3\u780110+\u5f20\u56fe\u7684\u805a\u7c7b\u795e\u5668ConsensusClusterPlus\uff08\u4e0a\uff09"},"content":{"rendered":"

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clustering\u3001PAM\u7b49\u3002\u8be5\u5305\u652f\u6301\u5728\u4e0d\u540c\u805a\u7c7b\u6570\uff08k\u503c\uff09\u4e0b\u8fd0\u884c\u5171\u8bc6\u805a\u7c7b\uff0c\u5e76\u4e14\u80fd\u591f\u81ea\u52a8\u9009\u62e9\u6700\u4f18\u7684\u805a\u7c7b\u6570\uff0c\u540c\u65f6\u8fd8\u63d0\u4f9b\u4e86\u53ef\u89c6\u5316\u5de5\u5177\uff0c\u4f8b\u5982\u8ddf\u8e2a\u56fe\u3001\u5171\u8bc6\u77e9\u9635\u7b49\uff0c\u65b9\u4fbf\u7528\u6237\u5bf9\u805a\u7c7b\u7ed3\u679c\u8fdb\u884c\u5206\u6790\u548c\u89e3\u91ca\u3002<\/p>\n<p style=\"white-space: normal;\">\u5728\u4f7f\u7528ConsensusClusterPlus\u65f6\uff0c\u9700\u8981\u8bbe\u7f6e\u4e00\u4e9b\u53c2\u6570\u4ee5\u83b7\u5f97\u6700\u4f73\u7684\u805a\u7c7b\u7ed3\u679c\u3002\u4e0b\u9762\u662fConsensusClusterPlus\u4e2d\u5e38\u7528\u7684\u53c2\u6570\u4ecb\u7ecd\uff1a<\/p>\n<p style=\"white-space: normal;\"><strong>d\uff1a<\/strong>\u8981\u805a\u7c7b\u7684\u6570\u636e\uff1b\u8981\u4e48\u662f\u4e00\u4e2a\u6570\u636e\u77e9\u9635\uff0c\u5176\u4e2d columns=items\/samples \u548c rows \u662f\u7279\u5f81\u3002\u4f8b\u5982\uff0c\u884c\u4e2d\u57fa\u56e0\u548c\u5217\u4e2d\u5fae\u9635\u5217\u7684\u57fa\u56e0\u8868\u8fbe\u77e9\u9635\uff0c\u6216 ExpressionSet \u5bf9\u8c61\uff0c\u6216\u8ddd\u79bb\u5bf9\u8c61\uff08\u4ec5\u9002\u7528\u4e8e\u6ca1\u6709\u7279\u5f81\u91cd\u91c7\u6837\u7684\u60c5\u51b5\uff09<\/p>\n<p style=\"white-space: normal;\"><strong>distance\uff1a<\/strong>\u8ddd\u79bb\u5ea6\u91cf\u65b9\u6cd5\uff0c\u53ef\u4ee5\u662f\u6b27\u51e0\u91cc\u5f97\u8ddd\u79bb\uff08”euclidean”\uff09\u3001\u76f8\u5173\u7cfb\u6570\uff08”correlation”\uff09\u3001\u76ae\u5c14\u900a\u76f8\u5173\u7cfb\u6570\uff08”pearson”\uff09\u7b49\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>maxK\uff1a<\/strong>\u805a\u7c7b\u6570\u8303\u56f4\uff0c\u6700\u5927\u805a\u7c7b\u6570\uff0c\u9700\u8981\u662f\u4e00\u4e2a\u6574\u6570\u503c\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>seed\uff1a<\/strong>\u4e3a\u53ef\u91cd\u73b0\u7684\u7ed3\u679c\u8bbe\u7f6e\u968f\u673a\u79cd\u5b50\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>reps\uff1a<\/strong>\u91cd\u590d\u6b21\u6570\uff0c\u8868\u793a\u5728\u6bcf\u4e2a\u805a\u7c7b\u6570\u4e0b\u8fdb\u884c\u7684\u968f\u673a\u62bd\u6837\u6b21\u6570\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>pItem\uff1a<\/strong>\u9879\u76ee\uff08\u5217\uff09\u7684\u5b50\u96c6\u5927\u5c0f\uff0c\u8868\u793a\u5728\u6bcf\u4e2a\u91cd\u590d\u4e2d\u8981\u62bd\u6837\u7684\u7279\u5f81\u6570\uff0c\u901a\u5e38\u8bbe\u7f6e\u4e3a\u6570\u636e\u96c6\u7684\u5e73\u65b9\u6839\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>clusterAlg\uff1a<\/strong>\u805a\u7c7b\u7b97\u6cd5\uff0c\u53ef\u4ee5\u662fk-means\uff08”km”\uff09\u3001hierarchical\uff08”hc”\uff09\u3001PAM\uff08”pam”\uff09\u7b49\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>pItemReplace\uff1a<\/strong>\u5728\u6bcf\u4e2a\u91cd\u590d\u4e2d\u662f\u5426\u66ff\u6362\u9009\u5b9a\u7684\u9879\u76ee\uff08\u5217\uff09\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>verbose\uff1a<\/strong>\u662f\u5426\u663e\u793a\u8fed\u4ee3\u8fc7\u7a0b\u7684\u8be6\u7ec6\u4fe1\u606f\uff0c\u5982\u679c\u4e3a TRUE\uff0c\u5219\u5c06\u6d88\u606f\u6253\u5370\u5230\u5c4f\u5e55\u4ee5\u6307\u793a\u8fdb\u5ea6\u3002\u8fd9\u5bf9\u4e8e\u5927\u578b\u6570\u636e\u96c6\u5f88\u6709\u7528\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>verbosePlot\uff1a<\/strong>\u662f\u5426\u663e\u793a\u7ed8\u56fe\u7684\u8be6\u7ec6\u4fe1\u606f\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>tmyPal\uff1a<\/strong>\u5171\u8bc6\u77e9\u9635\u7684\u53ef\u9009\u989c\u8272\u7279\u5f81\u5411\u91cf\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>ml\uff1a<\/strong>\u5148\u524d\u7684\u7ed3\u679c\uff0c\u5982\u679c\u63d0\u4f9b\u5219\u53ea\u505a\u56fe\u5f62\u548c\u8868\u683c\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>title\uff1a<\/strong>\u8f93\u51fa\u76ee\u5f55\u7684\u5b57\u7b26\u503c\u3002\u4ec5\u5f53 plot \u4e0d\u4e3a NULL \u6216 writeTable \u4e3a TRUE \u65f6\u624d\u521b\u5efa\u76ee\u5f55\u3002\u6b64\u6807\u9898\u53ef\u4ee5\u662f\u7edd\u5bf9\u8def\u5f84\u6216\u76f8\u5bf9\u8def\u5f84\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>plot\uff1a<\/strong>\u5b57\u7b26\u503c\u3002NULL – \u6253\u5370\u5230\u5c4f\u5e55\uff0c\u7528\u4e8e\u4f4d\u56fe png \u7684 ‘pdf’\u3001’png’\u3001’pngBMP’\uff0c\u6709\u52a9\u4e8e\u5927\u578b\u6570\u636e\u96c6\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>writeTable\uff1a<\/strong>TRUE – \u5c06\u8f93\u51fa\u548c\u65e5\u5fd7\u5199\u5165 csv\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>weightsItem\uff1a<\/strong>\u7528\u4e8e\u62bd\u6837\u9879\u76ee\u7684\u6743\u91cd\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>weightsFeature\uff1a<\/strong>\u7528\u4e8e\u62bd\u6837\u7279\u5f81\u7684\u6743\u91cd\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>res\uff1a<\/strong>consensusClusterPlus \u7684\u7ed3\u679c\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>innerLinkage\uff1a<\/strong>\u7528\u4e8e\u5b50\u91c7\u6837\u7684\u5206\u5c42\u94fe\u63a5\u65b9\u6cd5\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>finalLinkage\uff1a<\/strong>\u5171\u8bc6\u77e9\u9635\u7684\u5c42\u6b21\u94fe\u63a5\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u63a5\u4e0b\u6765\u5c31\u8ba9\u5c0f\u5e08\u59b9\u4ee5GEO\u6570\u636e\u5e93\u4e2d\u7684GSE10245\u6570\u636e\u96c6\u4e3a\u4f8b\u5e26\u4f60\u4f7f\u7528ConsensusClusterPlus\uff0c\u8be5\u6570\u636e\u96c6\u5305\u542b\u4e86\u4eba\u7c7b\u80ba\u764c\u7ec4\u7ec7\u548c\u6b63\u5e38\u80ba\u7ec4\u7ec7\u7684\u57fa\u56e0\u8868\u8fbe\u6570\u636e\u3002<\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5bfc\u5165\u6570\u636e<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">library(GEOquery)<\/span><\/code><code><span class=\"code-snippet_outer\">gse <- getGEO(<span class=\"code-snippet__string\">\"GSE10245\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">data <- exprs(gse[[<span class=\"code-snippet__number\">1<\/span>]])<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u6570\u636e\u9884\u5904\u7406\uff0c\u8fdb\u884c\u6570\u636e\u6807\u51c6\u5316<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">library(limma)<\/span><\/code><code><span class=\"code-snippet_outer\">data <- normalizeBetweenArrays(data, method=<span class=\"code-snippet__string\">\"quantile\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5bfc\u5165ConsensusClusterPlus\u5305\uff0c\u5bf9\u6570\u636e\u8fdb\u884c\u805a\u7c7b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">library(ConsensusClusterPlus)<\/span><\/code><code><span class=\"code-snippet_outer\">ccp <- ConsensusClusterPlus(data, maxK=<span class=\"code-snippet__number\">5<\/span>, reps=<span class=\"code-snippet__number\">100<\/span>, distance=<span class=\"code-snippet__string\">\"pearson\"<\/span>, clusterAlg=<span class=\"code-snippet__string\">\"km\"<\/span>)<\/span><\/code><\/pre>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u63a5\u4e0b\u6765\u6211\u4eec\u5c31\u53ef\u4ee5\u5f97\u52308\u5f20\u805a\u7c7b\u7ed3\u679c\u7684\u56fe\u7247\uff0c\u5206\u522b\u662f\uff1a<br \/><\/p>\n<p style=\"white-space: normal;\">\u56db\u79cd\u5206\u7c7b\u7684\u4e00\u81f4\u6027\u77e9\u9635\u548c\u989c\u8272\u7684\u6807\u8bc6<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9241573033707865\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_dcxbeicsfPV0MZZAZicrrCmFVgxibg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNBcibXNksKj5nwUO369z32sEvGEp3dcxbeicsfPV0MZZAZicrrCmFVgxibg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"712\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.38996138996139\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_AB2xan4s43LkowtLwzOgF2F6eFGS6g-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNSDiaxm9soeGA5kfl74EmsprWcAB2xan4s43LkowtLwzOgF2F6eFGS6g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"518\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.320754716981132\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_P4pHyb64Kkvncuh0FyicgicYtdFicA-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNJrBJWRqgIq3DZ5vibtkUjvauxjwFP4pHyb64Kkvncuh0FyicgicYtdFicA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"530\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.193103448275862\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_FpXx1fpWNQibia2ib027SbqJTBaqCg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNK4G86A9OBZqJOUozrPIXpd59QvaFpXx1fpWNQibia2ib027SbqJTBaqCg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"580\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.2304964539007093\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_rC3TX3aHuOQpaayJ3K8JAQU4mT09dQ-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNFicjwFwsRvP0wVeLy04g34OKyrC3TX3aHuOQpaayJ3K8JAQU4mT09dQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"564\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"text-align: center;white-space: normal;\" powered-by=\"xiumi.us\"><span style=\"font-size: 12px;color: rgb(160, 160, 160);\">\u4e00\u81f4\u6027\u7d2f\u79ef\u5206\u5e03\u51fd\u6570\u56fe<\/span><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5805555555555556\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_jm4EPUn75v8lkWCwLQHCvfkvRScCxg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNhKypWqeia12SpPAuDlSGOrZAVjm4EPUn75v8lkWCwLQHCvfkvRScCxg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"text-align: center;white-space: normal;\" powered-by=\"xiumi.us\"><span style=\"font-size: 12px;color: rgb(160, 160, 160);\">\u788e\u77f3\u56fe<\/span><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6018518518518519\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_nFdaXZVBTGdRSAOguVicdbTUujIsWQ-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNmjcJibdcdJ3LeHpADVvscMAtRicnFdaXZVBTGdRSAOguVicdbTUujIsWQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"text-align: center;white-space: normal;\" powered-by=\"xiumi.us\"><span style=\"font-size: 12px;color: rgb(160, 160, 160);\">\u8ddf\u8e2a\u56fe<\/span><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6240740740740741\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_w8aA30ogwVBQnkic5mMo01K06MtxKQ-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNGq13yFCfqY9lWWia3ia0KagF21Uw8aA30ogwVBQnkic5mMo01K06MtxKQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u63a5\u4e0b\u6765\u4f7f\u7528calcICL\u51fd\u6570\u8ba1\u7b97\u805a\u7c7b\u4e00\u81f4\u6027\u548c\u6837\u54c1\u4e00\u81f4\u6027<br \/><\/p>\n<p style=\"white-space: normal;\">icl <- calcICL(ccp)<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5638888888888889\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_ArphGwdHdIB4aglgrISWGBsP3s0fhA-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNq6iavtW8SNHMkGKyZ5rDFSrOHArphGwdHdIB4aglgrISWGBsP3s0fhA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.18425925925925926\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_s2ktibslQxh75gE8UojUz8msMEpwVA-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNDQQkQoXX07fWMYcOMnnfq5o6Js2ktibslQxh75gE8UojUz8msMEpwVA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.1925925925925926\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_aUtogZCbFibhad76jFwaF6bOYpUFZw-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/oCSOtP61aEVf1VJJZOUxwO2pKGibibNzWNogvTpxnLicb3CVh80kq0j6zmkfiaUtogZCbFibhad76jFwaF6bOYpUFZw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">ConsensusClusterPlus\u77ed\u77ed\u4e24\u884c\u4ee3\u7801\u5c31\u80fd\u5e26\u6765\u805a\u7c7b\u5206\u6790\u548c14\u5f20\u53ef\u89c6\u5316\u56fe\u7247\uff0c\u662f\u4e0d\u662f\u5f88\u795e\u5947\u5462\uff1f\u76f8\u4fe1\u4e5f\u6709\u8bb8\u591a\u5c0f\u4f19\u4f34\u5bf9\u8fd914\u5f20\u56fe\u7684\u611f\u5230\u56f0\u60d1\uff0c\u4e0b\u4e00\u671f\u5c0f\u5e08\u59b9\u5c06\u7ed9\u5927\u5bb6\u7ec6\u7ec6\u9053\u6765\u6bcf\u5f20\u56fe\u7684\u610f\u4e49\uff5e\u656c\u8bf7\u671f\u5f85\uff5e<\/p>\n<p style=\"white-space: normal;\">\u66f4\u591a\u5b9e\u7528\u65b9\u4fbf\u7684\u5c0f\u5de5\u5177\u5728\u4e91\u751f\u4fe1\u5e73\u53f0\u7b49\u7740\u4f60\u54e6<\/p>\n<p style=\"white-space: normal;\"><strong>http:\/\/www.biocloudservice.com\/home.html<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"letter-spacing: 0.578px;white-space: normal;font-size: 16px;margin-bottom: 24px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;\">\n<section style=\"margin-right: 10px;display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;height: auto;align-self: center;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"background-color: rgb(249, 172, 172);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"margin-right: 10px;padding-right: 8px;padding-left: 8px;display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;border-style: solid;border-width: 1px;border-color: rgb(249, 172, 172);\">\n<section powered-by=\"xiumi.us\" style=\"text-align: justify;color: rgb(249, 172, 172);\">\n<p>E<\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 10px;padding-right: 8px;padding-left: 8px;display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;border-style: solid;border-width: 1px;border-color: rgb(249, 172, 172);\">\n<section powered-by=\"xiumi.us\" style=\"text-align: justify;color: rgb(249, 172, 172);\">\n<p>N<\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 10px;padding-right: 8px;padding-left: 8px;display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 0 0 auto;min-width: 5%;height: auto;border-style: solid;border-width: 1px;border-color: rgb(249, 172, 172);\">\n<section powered-by=\"xiumi.us\" style=\"text-align: justify;color: rgb(249, 172, 172);\">\n<p>D<\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;flex: 100 100 0%;height: auto;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"background-color: rgb(249, 172, 172);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"letter-spacing: 0.578px;white-space: normal;text-align: center;margin-bottom: 24px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.5555555555555556\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_icWAmgGMVEzREAJmM59ov44ziaMCGg-2.jpg?w=640\" 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[…]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/59015"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=59015"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/59015\/revisions"}],"predecessor-version":[{"id":59028,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/59015\/revisions\/59028"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=59015"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=59015"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=59015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}