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255);text-align: right;letter-spacing: 4px;\" powered-by=\"xiumi.us\">\n<p><strong>\u70b9\u51fb\u84dd\u5b57<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;border-left: 4px solid rgb(242, 183, 183);border-bottom-left-radius: 0px;flex: 100 100 0%;align-self: stretch;height: auto;padding: 3px 10px;background-color: rgba(254, 245, 240, 0.8);\">\n<section style=\"color: rgb(181, 126, 121);font-size: 17px;letter-spacing: 4px;\" powered-by=\"xiumi.us\">\n<p><strong>\u5173\u6ce8\u5c0f\u56fe<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5c0f\u56fe\u5728\u4e0a\u4e00\u7bc7\u6587\u7ae0\uff1a<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247483730&idx=1&sn=abc7095012e15da0a0c27ec4d79ec243&chksm=c1b17caff6c6f5b93c5fc3b02da32d7e65aaf6063f50cde671373bf81595115c30ae0235ffb1&scene=21#wechat_redirect\" textvalue=\"GSEA\u5bcc\u96c6\u5206\u6790\u2014\u2014\u770b\u4e86\u4e4b\u540e\uff0c\u5c0f\u5b66\u4e09\u5e74\u7ea7\u7684\u59b9\u59b9\u90fd\u5b66\u4f1a\u4e86\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\"><span style=\"text-decoration: underline;\"><strong>GSEA\u5bcc\u96c6\u5206\u6790\u2014\u2014\u770b\u4e86\u4e4b\u540e\uff0c\u5c0f\u5b66\u4e09\u5e74\u7ea7\u7684\u59b9\u59b9\u90fd\u5b66\u4f1a\u4e86\uff01<\/strong><\/span><\/a><span style=\"text-decoration: underline;\"><\/span>\u4e2d\uff0c\u4ecb\u7ecd\u4e86\u5982\u4f55\u4f7f\u7528 GSEA\u8fdb\u884c\u5bcc\u96c6\u5206\u6790\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u6709\u5c0f\u4f19\u4f34\u7eb7\u7eb7\u53cd\u6620\uff0cGSEA\u7ed3\u679c\u4e0d\u4f1a\u89e3\u8bfb<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: 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onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhYfZxaDrGISeKyruiaJUhVjhotYrGtnJTCC1CoXcpoOS9M7RxTk6NJGA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"365\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u70b9\u51fb<span style=\"color: rgb(225, 109, 109);\"><strong>index.html<\/strong><\/span><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.47962962962962963\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_KiaCzlwXfW9KtGXwtJdCEkYM8GuXNw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhfbldx09Hq52IWDjVHVRYG6XJdKiaCzlwXfW9KtGXwtJdCEkYM8GuXNw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u7f51\u9875\u62a5\u544a\u4e2d<span style=\"text-decoration: underline;\">\u4e0b\u5212\u7ebf<\/span>\u90e8\u5206\u90fd\u53ef\u4ee5\u70b9\u51fb\uff0c\u94fe\u63a5\u5230\u5176\u4ed6\u7f51\u9875\u6216\u8005\u6587\u4ef6\u67e5\u770b\u5177\u4f53\u4fe1\u606f\u3002<\/p>\n<p style=\"white-space: normal;\">\u70b9\u51fb<strong><span style=\"color: rgb(225, 109, 109);\">Snapshot<\/span><\/strong>\u4f1a\u51fa\u73b0\u8fd9114\u6761\u901a\u8def\u7684\u6761\u5f62\u7801\u5bcc\u96c6\u56fe\uff0c\u5982\u4e0b\uff1a<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7324074074074074\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_313NsAnkS4w5ScYibsmibK5FNKq1xg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZh3p2WMFFibNvh8UKv75jRm4z78gm313NsAnkS4w5ScYibsmibK5FNKq1xg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u70b9\u51fb<span style=\"color: rgb(225, 109, 109);\"><strong>enrichment results in html format<\/strong><\/span>\u5219\u4f1a\u663e\u793a\u8fd9114\u6761\u901a\u8def\u7684\u5bcc\u96c6\u8be6\u60c5\uff1a<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.1712962962962963\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_pttQz5zziaEE766yxBcX7byPXVtZuA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhYmibwo6aLwVAdnguG9NIAXnKrnpttQz5zziaEE766yxBcX7byPXVtZuA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"display: flex;flex-flow: row nowrap;margin: 10px 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-bottom: 3px solid rgb(242, 183, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;align-self: flex-start;height: auto;padding-bottom: 3px;\">\n<section style=\"text-align: justify;font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u8bfb\u5230\u8fd9\u91cc\uff0c\u60f3\u5fc5\u56fe\u4e2d\u7684\u7f29\u5199\u5c0f\u4f19\u4f34\u770b\u7684\u4e00\u5934\u96fe\u6c34\u5427\uff0c\u5c0f\u56fe\u6765\u4e00\u4e00\u9053\u6765<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>GS\uff1a<\/strong>\u57fa\u56e0\u96c6\u7684\u540d\u79f0\uff08GO term\u6216KEGG pathway\u540d\u79f0\uff09<\/p>\n<p style=\"white-space: normal;\"><strong>Size\uff1a<\/strong>\u901a\u8def\/\u6761\u76ee\u4e0b\u5305\u542b\u7684\u57fa\u56e0\u6570\u76ee\uff08\u7ecf\u8fc7\u6761\u4ef6\u7b5b\u9009\u540e\u7684\u503c\uff09<\/p>\n<p style=\"white-space: normal;\"><strong>ES\uff1a<\/strong>\u5bcc\u96c6\u5f97\u5206\uff08enrichment score\uff09<\/p>\n<p style=\"white-space: normal;\"><strong>NES\uff1a<\/strong>ES\u7684\u6807\u51c6\u5316\u503c\uff08normalized enrichment score\uff09\uff0c\u540c\u65f6\u8003\u8651\u57fa\u56e0\u96c6\u7684\u4e2a\u6570\u53ca\u57fa\u56e0\u6570\u76ee\uff0cNES\u7684\u503c\u4ee3\u8868\u8be5\u57fa\u56e0\u96c6\u4e2d\u7684\u57fa\u56e0\u5728\u6574\u4f53\u57fa\u56e0\u6392\u5e8f\u5217\u8868\u4e2d\u7684\u5bcc\u96c6\u7a0b\u5ea6\u3002\u7b80\u5355\u7406\u89e3NES\u4e3a\u6b63\u503c\u57fa\u56e0\u96c6\u4e0a\u8c03\uff0c\u8d1f\u503c\u57fa\u56e0\u96c6\u4e0b\u8c03\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>NOM p-val\uff1a<\/strong>P-value\uff0c\u9488\u5bf9ES\u7684\u6392\u5217\u68c0\u9a8c\uff0c\u8868\u793a\u57fa\u56e0\u96c6\u5bcc\u96c6\u7684\u663e\u8457\u6027<\/p>\n<p style=\"white-space: normal;\"><strong>FDR q-val\uff1a<\/strong>FDR\u6cd5\u6821\u6b63\u7684p\u503c<\/p>\n<p style=\"white-space: normal;\"><strong>FWER p-val\uff1a<\/strong>\u7528FWER\u6cd5\uff08Bonferonni\u6821\u6b63\uff09\u6821\u6b63\u540e\u7684P\u503c<\/p>\n<p style=\"white-space: normal;\"><strong>RANK AT MAX\uff1a<\/strong>\u5f53ES\u503c\u8fbe\u5230\u6700\u5927\u65f6\u5bf9\u5e94\u7684\u90a3\u4e2a\u57fa\u56e0\u5728\u6392\u5e8f\u597d\u7684\u57fa\u56e0\u5217\u8868\u4e2d\u6240\u5904\u7684\u4f4d\u7f6e<\/p>\n<p style=\"white-space: normal;\"><strong>LEADING \uff1a<\/strong>\u6838\u5fc3\u57fa\u56e0\u96c6\uff0c\u5bf9ES\u8d21\u732e\u6700\u5927\u7684\u57fa\u56e0\u6210\u5458\uff1b\u8be5\u5904\u67093\u4e2a\u7edf\u8ba1\u503c\uff1a<\/p>\n<p style=\"white-space: normal;\"><strong>tags\uff1a<\/strong>\u6838\u5fc3\u57fa\u56e0\u96c6\u5360\u8be5\u57fa\u56e0\u96c6\u4e2d\u57fa\u56e0\u603b\u6570\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n<p style=\"white-space: normal;\"><strong>list\uff1a<\/strong>\u6838\u5fc3\u57fa\u56e0\u5360\u6240\u6709\u57fa\u56e0\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n<p style=\"white-space: normal;\"><strong>signal\uff1a<\/strong>\u5c06\u524d\u4e24\u9879\u7edf\u8ba1\u6570\u636e\u5408\u5728\u4e00\u8d77\u8ba1\u7b97\u51fa\u7684\u5bcc\u96c6\u4fe1\u53f7\u5f3a\u5ea6\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u4e00\u822c\u8ba4\u4e3a|NES|>1\uff0cNOM p-val<0.05\uff0cFDR q-val<0.25\u7684\u901a\u8def\u662f\u663e\u8457\u5bcc\u96c6\u7684\u3002<\/p>\n<p style=\"white-space: normal;\">\u70b9\u51fbdetail\u67e5\u770b\u57fa\u56e0\u96c6\u5bcc\u96c6\u7684\u8be6\u7ec6\u7ed3\u679c\uff0cGSEA\u9ed8\u8ba4\u5c55\u793a\u524d20\u4e2a\u57fa\u56e0\u96c6\u7ed3\u679c\u3002\u4ee5RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY\u901a\u8def\u4e3a\u4f8b\uff1a<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u6253\u5f00\u540e\uff0c\u9875\u9762\u5982\u4e0b\uff1a<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.44722222222222224\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_EFRwMOf8gibNykdkcuude7YmdFC1GQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhUjld6OtLf7MAt3qiaFpen8ZMNrEFRwMOf8gibNykdkcuude7YmdFC1GQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"display: flex;flex-flow: row nowrap;margin: 10px 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-bottom: 3px solid rgb(242, 183, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;align-self: flex-start;height: auto;padding-bottom: 3px;\">\n<section style=\"text-align: justify;font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u770b\u6765\u53c8\u5230\u89e3\u8bfb\u65f6\u95f4\u4e86\u2014\u2014<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u5982\u4e0a\u56fe\uff0c\u63cf\u8ff0\u7684\u4fe1\u606f\u4e3a\uff1aRIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY \u901a\u8def\u5728A\u7ec4\u4e0a\u8c03\uff08\u663e\u8457\u5bcc\u96c6\u5728 A \u7684\u9876\u7aef\uff09\uff0c\u7136\u540e\u662f\u5426\u663e\u8457\u5462\uff1f\u540e\u9762\u7684 ES\u3001NES\u3001pval\u3001FDR \u7b49\u7edf\u8ba1\u503c\u7ed9\u51fa\u4e86\u7b54\u6848\u3002<br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5898148148148148\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_3pMrzqlT59EaZhNKhBELia5hQHPU3A.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhtt3XNjEI15zdBwiadlkZlcEVpX3pMrzqlT59EaZhNKhBELia5hQHPU3A\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"display: flex;flex-flow: row nowrap;margin: 10px 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-bottom: 3px solid rgb(242, 183, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;align-self: flex-start;height: auto;padding-bottom: 3px;\">\n<section style=\"text-align: justify;font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u518d\u63a5\u518d\u5389\u2014\u2014<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5982\u4e0a\u56fe\uff0c\u5bcc\u96c6\u56fe\u4e00\u5171\u5206\u4e3a\u4e0a\u4e2d\u4e0b 3 \u90e8\u5206\uff1a<br \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u7b2c\u4e00\u90e8\u5206 ES \u6298\u7ebf\u56fe\uff1a<\/strong>\u663e\u793a\u4e86\u5f53\u5206\u6790\u6cbf\u7740\u6392\u5e8f\u57fa\u56e0\u96c6\u6309\u6392\u5e8f\u8ba1\u7b97\u65f6\uff0cES \u503c\u5728\u8ba1\u7b97\u5230\u6bcf\u4e2a\u4f4d\u7f6e\u65f6\u7684\u5c55\u793a\u3002\u6700\u9ad8\u5cf0\u5904\u7684ES\u5f97\u5206\u662f\u57fa\u56e0\u96c6\u7684 ES \u503c\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u7b2c\u4e8c\u90e8\u5206 hits \u56fe\uff1a<\/strong>\u4fd7\u79f0\u6761\u5f62\u7801\u56fe\uff0c\u7528\u7ebf\u6761\u6216\u8005 hit \u6807\u8bb0\u4e86\u901a\u8def\u57fa\u56e0\u96c6\u4e2d\u6210\u5458\u51fa\u73b0\u5728\u57fa\u56e0\u6392\u5e8f\u5217\u8868\u4e2d\u7684\u4f4d\u7f6e\u3002leading edge subset \u5c31\u662f\uff080,0\uff09\u5230\u7eff\u8272\u66f2\u7ebf\u5cf0\u503c ES \u51fa\u73b0\u5bf9\u5e94\u7684\u8fd9\u90e8\u5206\u57fa\u56e0\uff08x\u8f740\u5230\u865a\u7ebf\u90a3\u90e8\u5206\uff09\u3002<\/p>\n<p style=\"white-space: normal;\">\u6240\u8c13Leading-edge subset\uff0c\u5c31\u662f\u5bf9\u5bcc\u96c6\u5f97\u5206\u8d21\u732e\u6700\u5927\u7684\u57fa\u56e0\u6210\u5458\u3002\u5982\u679cES\u5f97\u5206\u90fd\u662f\u6b63\u503c\uff08\u5982\u4e0a\u56fe\u6240\u793a\uff09\uff0c\u90a3\u4e48Leading-edge subset\u5c31\u5728\u5cf0\u503cES\u7684\u5de6\u4fa7\uff0c\u53cd\u4e4b\u5219\u5728\u53f3\u4fa7\uff08\u5e95\u90e8\u5bcc\u96c6 = A\/C \u4e0b\u8c03\u8868\u8fbe = C\u7ec4\u9ad8\u8868\u8fbe\uff09\u3002\u90a3\u4e48\u6839\u636e\u672c\u56fe\u6211\u4eec\u5f88\u5bb9\u6613\u770b\u51fa\uff0c\u8be5\u901a\u8def\u5728 A \u7ec4\u9ad8\u8868\u8fbe\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u7b2c\u4e09\u90e8\u5206\u662f\u6392\u5e8f\u540e\u6240\u6709\u57fa\u56e0 rank \u503c\u7684\u5206\u5e03<\/strong>\uff0c\u70ed\u56fe\u7ea2\u8272\u90e8\u5206\u5bf9\u5e94\u7684\u57fa\u56e0\u5728 A \u7ec4\u9ad8\u8868\u8fbe\uff0c\u84dd\u8272\u90e8\u5206\u5bf9\u5e94\u7684\u57fa\u56e0\u5728 C\u7ec4\u9ad8\u8868\u8fbe\uff0c\u6bcf\u4e2a\u57fa\u56e0\u5bf9\u5e94\u7684\u4fe1\u566a\u6bd4\uff08Signal2noise\uff0c\u524d\u9762\u9009\u62e9\u7684\u6392\u5e8f\u503c\u8ba1\u7b97\u65b9\u5f0f\uff09\u4ee5\u7070\u8272\u9762\u79ef\u56fe\u5c55\u793a\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6435185185185185\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_y7ibNAsBwf38ZsMz3m7icicflqIPTA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhvVUjLDpPUaf945BDNicgeXwVEPlZy7ibNAsBwf38ZsMz3m7icicflqIPTA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9453703703703704\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_aO0nTPhtKeDqABafhYTygH1mGRHYEg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhF4OhbPzVxjz8UQEMZCLrMWTfiaO0nTPhtKeDqABafhYTygH1mGRHYEg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u7ed3\u679c\u4e2d\u8be6\u7ec6\u7ed9\u51fa\u4e86\u8be5\u57fa\u56e0\u96c6\u4e0b\u5305\u542b\u7684\u57fa\u56e0\u7684\u5177\u4f53\u4fe1\u606f\u548c\u524d100\u4e2a\u57fa\u56e0\u4f7f\u7528\u70ed\u56fe\u8fdb\u884c\u5c55\u793a\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u770b\u8fc7\u5c0f\u56fe\u7684\u89e3\u8bfb\u540e\u662f\u4e0d\u662f\u53d1\u73b0GSEA\u4e5f\u4e0d\u8fc7\u5982\u6b64\uff1f\u4e0b\u8bfe\u540e\u8d76\u7d27\u884c\u52a8\u8d77\u6765\u8ba9\u5c0f\u56fe\u770b\u770b\u5927\u5bb6\u7684\u5b66\u4e60\u6210\u679c\uff0c\u6b22\u8fce\u5728\u8bc4\u8bba\u533a\u4e00\u8d77\u8ba8\u8bba\uff01<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;border-color: rgb(176, 176, 176);padding: 7px;\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: 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<\/a><\/span><em id=\"publish_time\" class=\"rich_media_meta rich_media_meta_text\">2023-07-14 19:00:44<\/em><\/div>\n<p><content><\/p>\n<div class=\"reprint\">\n<p>\u8f6c\u81ea\u516c\u4f17\u53f7\uff1a\u751f\u4fe1\u56fe<br \/><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247483755&idx=1&sn=3e563339dc16d85b4b2cf8562af1c6d1\" target=\"_blank\" title=\"\u9605\u8bfb\u539f\u6587\" rel=\"noopener\">http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247483755&idx=1&sn=3e563339dc16d85b4b2cf8562af1c6d1<\/a><\/p>\n<\/div>\n<section style=\"font-size: 16px;margin-bottom: 24px;\">\n<section style=\"display: flex;flex-flow: row nowrap;margin: 10px 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: 50%;background-color: rgb(242, 183, 183);margin-right: 3px;flex: 0 0 auto;align-self: flex-end;height: auto;padding: 3px 10px;\">\n<section style=\"font-size: 17px;color: rgb(255, 255, 255);text-align: right;letter-spacing: 4px;\" powered-by=\"xiumi.us\">\n<p><strong>\u70b9\u51fb\u84dd\u5b57<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: auto;border-left: 4px solid rgb(242, 183, 183);border-bottom-left-radius: 0px;flex: 100 100 0%;align-self: stretch;height: auto;padding: 3px 10px;background-color: rgba(254, 245, 240, 0.8);\">\n<section style=\"color: rgb(181, 126, 121);font-size: 17px;letter-spacing: 4px;\" powered-by=\"xiumi.us\">\n<p><strong>\u5173\u6ce8\u5c0f\u56fe<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5c0f\u56fe\u5728\u4e0a\u4e00\u7bc7\u6587\u7ae0\uff1a<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247483730&idx=1&sn=abc7095012e15da0a0c27ec4d79ec243&chksm=c1b17caff6c6f5b93c5fc3b02da32d7e65aaf6063f50cde671373bf81595115c30ae0235ffb1&scene=21#wechat_redirect\" textvalue=\"GSEA\u5bcc\u96c6\u5206\u6790\u2014\u2014\u770b\u4e86\u4e4b\u540e\uff0c\u5c0f\u5b66\u4e09\u5e74\u7ea7\u7684\u59b9\u59b9\u90fd\u5b66\u4f1a\u4e86\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\"><span style=\"text-decoration: underline;\"><strong>GSEA\u5bcc\u96c6\u5206\u6790\u2014\u2014\u770b\u4e86\u4e4b\u540e\uff0c\u5c0f\u5b66\u4e09\u5e74\u7ea7\u7684\u59b9\u59b9\u90fd\u5b66\u4f1a\u4e86\uff01<\/strong><\/span><\/a><span style=\"text-decoration: underline;\"><\/span>\u4e2d\uff0c\u4ecb\u7ecd\u4e86\u5982\u4f55\u4f7f\u7528 GSEA\u8fdb\u884c\u5bcc\u96c6\u5206\u6790\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u6709\u5c0f\u4f19\u4f34\u7eb7\u7eb7\u53cd\u6620\uff0cGSEA\u7ed3\u679c\u4e0d\u4f1a\u89e3\u8bfb<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u90a3\u4e48\u597d\uff0c\u54b3\u54b3~\u5c0f\u56fe\u3010\u4e00\u6587\u4e00\u5206\u949f\u3011\u8bfe\u5802\u5f00\u8bfe<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"display: flex;flex-flow: row nowrap;margin: 10px 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-bottom: 3px solid rgb(242, 183, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;align-self: flex-start;height: auto;padding-bottom: 3px;\">\n<section style=\"text-align: justify;font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u4eca\u5929\u5c0f\u56fe\u8981\u89e3\u51b3\u7684\u95ee\u9898\u4fbf\u662f\uff1a<span style=\"color: rgb(110, 75, 36);\">GSEA \u7684\u5206\u6790\u7ed3\u679c\u600e\u4e48\u770b\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u8bdd\u4e0d\u591a\u8bf4~\u73b0\u5728\u5f00\u59cb<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u5c0f\u56fe\u6536\u5230GSEA\u5206\u6790\u7ed3\u679c\u540e\uff0c\u6253\u5f00GSEA\u6587\u4ef6\u5939\uff0c\u53ef\u4ee5\u901a\u8fc7\u641c\u7d22\u201cindex\u201d\uff0c\u67e5\u770bGSEA\u5206\u6790\u7ed3\u679c\uff1a<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6328767123287671\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_YrGtnJTCC1CoXcpoOS9M7RxTk6NJGA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhYfZxaDrGISeKyruiaJUhVjhotYrGtnJTCC1CoXcpoOS9M7RxTk6NJGA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"365\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u70b9\u51fb<span style=\"color: rgb(225, 109, 109);\"><strong>index.html<\/strong><\/span><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.47962962962962963\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_KiaCzlwXfW9KtGXwtJdCEkYM8GuXNw.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhfbldx09Hq52IWDjVHVRYG6XJdKiaCzlwXfW9KtGXwtJdCEkYM8GuXNw\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u7f51\u9875\u62a5\u544a\u4e2d<span style=\"text-decoration: underline;\">\u4e0b\u5212\u7ebf<\/span>\u90e8\u5206\u90fd\u53ef\u4ee5\u70b9\u51fb\uff0c\u94fe\u63a5\u5230\u5176\u4ed6\u7f51\u9875\u6216\u8005\u6587\u4ef6\u67e5\u770b\u5177\u4f53\u4fe1\u606f\u3002<\/p>\n<p style=\"white-space: normal;\">\u70b9\u51fb<strong><span style=\"color: rgb(225, 109, 109);\">Snapshot<\/span><\/strong>\u4f1a\u51fa\u73b0\u8fd9114\u6761\u901a\u8def\u7684\u6761\u5f62\u7801\u5bcc\u96c6\u56fe\uff0c\u5982\u4e0b\uff1a<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7324074074074074\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_313NsAnkS4w5ScYibsmibK5FNKq1xg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZh3p2WMFFibNvh8UKv75jRm4z78gm313NsAnkS4w5ScYibsmibK5FNKq1xg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u70b9\u51fb<span style=\"color: rgb(225, 109, 109);\"><strong>enrichment results in html format<\/strong><\/span>\u5219\u4f1a\u663e\u793a\u8fd9114\u6761\u901a\u8def\u7684\u5bcc\u96c6\u8be6\u60c5\uff1a<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.1712962962962963\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_pttQz5zziaEE766yxBcX7byPXVtZuA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhYmibwo6aLwVAdnguG9NIAXnKrnpttQz5zziaEE766yxBcX7byPXVtZuA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"display: flex;flex-flow: row nowrap;margin: 10px 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-bottom: 3px solid rgb(242, 183, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;align-self: flex-start;height: auto;padding-bottom: 3px;\">\n<section style=\"text-align: justify;font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u8bfb\u5230\u8fd9\u91cc\uff0c\u60f3\u5fc5\u56fe\u4e2d\u7684\u7f29\u5199\u5c0f\u4f19\u4f34\u770b\u7684\u4e00\u5934\u96fe\u6c34\u5427\uff0c\u5c0f\u56fe\u6765\u4e00\u4e00\u9053\u6765<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>GS\uff1a<\/strong>\u57fa\u56e0\u96c6\u7684\u540d\u79f0\uff08GO term\u6216KEGG pathway\u540d\u79f0\uff09<\/p>\n<p style=\"white-space: normal;\"><strong>Size\uff1a<\/strong>\u901a\u8def\/\u6761\u76ee\u4e0b\u5305\u542b\u7684\u57fa\u56e0\u6570\u76ee\uff08\u7ecf\u8fc7\u6761\u4ef6\u7b5b\u9009\u540e\u7684\u503c\uff09<\/p>\n<p style=\"white-space: normal;\"><strong>ES\uff1a<\/strong>\u5bcc\u96c6\u5f97\u5206\uff08enrichment score\uff09<\/p>\n<p style=\"white-space: normal;\"><strong>NES\uff1a<\/strong>ES\u7684\u6807\u51c6\u5316\u503c\uff08normalized enrichment score\uff09\uff0c\u540c\u65f6\u8003\u8651\u57fa\u56e0\u96c6\u7684\u4e2a\u6570\u53ca\u57fa\u56e0\u6570\u76ee\uff0cNES\u7684\u503c\u4ee3\u8868\u8be5\u57fa\u56e0\u96c6\u4e2d\u7684\u57fa\u56e0\u5728\u6574\u4f53\u57fa\u56e0\u6392\u5e8f\u5217\u8868\u4e2d\u7684\u5bcc\u96c6\u7a0b\u5ea6\u3002\u7b80\u5355\u7406\u89e3NES\u4e3a\u6b63\u503c\u57fa\u56e0\u96c6\u4e0a\u8c03\uff0c\u8d1f\u503c\u57fa\u56e0\u96c6\u4e0b\u8c03\u3002<\/p>\n<p style=\"white-space: normal;\"><strong>NOM p-val\uff1a<\/strong>P-value\uff0c\u9488\u5bf9ES\u7684\u6392\u5217\u68c0\u9a8c\uff0c\u8868\u793a\u57fa\u56e0\u96c6\u5bcc\u96c6\u7684\u663e\u8457\u6027<\/p>\n<p style=\"white-space: normal;\"><strong>FDR q-val\uff1a<\/strong>FDR\u6cd5\u6821\u6b63\u7684p\u503c<\/p>\n<p style=\"white-space: normal;\"><strong>FWER p-val\uff1a<\/strong>\u7528FWER\u6cd5\uff08Bonferonni\u6821\u6b63\uff09\u6821\u6b63\u540e\u7684P\u503c<\/p>\n<p style=\"white-space: normal;\"><strong>RANK AT MAX\uff1a<\/strong>\u5f53ES\u503c\u8fbe\u5230\u6700\u5927\u65f6\u5bf9\u5e94\u7684\u90a3\u4e2a\u57fa\u56e0\u5728\u6392\u5e8f\u597d\u7684\u57fa\u56e0\u5217\u8868\u4e2d\u6240\u5904\u7684\u4f4d\u7f6e<\/p>\n<p style=\"white-space: normal;\"><strong>LEADING \uff1a<\/strong>\u6838\u5fc3\u57fa\u56e0\u96c6\uff0c\u5bf9ES\u8d21\u732e\u6700\u5927\u7684\u57fa\u56e0\u6210\u5458\uff1b\u8be5\u5904\u67093\u4e2a\u7edf\u8ba1\u503c\uff1a<\/p>\n<p style=\"white-space: normal;\"><strong>tags\uff1a<\/strong>\u6838\u5fc3\u57fa\u56e0\u96c6\u5360\u8be5\u57fa\u56e0\u96c6\u4e2d\u57fa\u56e0\u603b\u6570\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n<p style=\"white-space: normal;\"><strong>list\uff1a<\/strong>\u6838\u5fc3\u57fa\u56e0\u5360\u6240\u6709\u57fa\u56e0\u7684\u767e\u5206\u6bd4\uff1b<\/p>\n<p style=\"white-space: normal;\"><strong>signal\uff1a<\/strong>\u5c06\u524d\u4e24\u9879\u7edf\u8ba1\u6570\u636e\u5408\u5728\u4e00\u8d77\u8ba1\u7b97\u51fa\u7684\u5bcc\u96c6\u4fe1\u53f7\u5f3a\u5ea6\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u4e00\u822c\u8ba4\u4e3a|NES|>1\uff0cNOM p-val<0.05\uff0cFDR q-val<0.25\u7684\u901a\u8def\u662f\u663e\u8457\u5bcc\u96c6\u7684\u3002<\/p>\n<p style=\"white-space: normal;\">\u70b9\u51fbdetail\u67e5\u770b\u57fa\u56e0\u96c6\u5bcc\u96c6\u7684\u8be6\u7ec6\u7ed3\u679c\uff0cGSEA\u9ed8\u8ba4\u5c55\u793a\u524d20\u4e2a\u57fa\u56e0\u96c6\u7ed3\u679c\u3002\u4ee5RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY\u901a\u8def\u4e3a\u4f8b\uff1a<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u6253\u5f00\u540e\uff0c\u9875\u9762\u5982\u4e0b\uff1a<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.44722222222222224\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_EFRwMOf8gibNykdkcuude7YmdFC1GQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhUjld6OtLf7MAt3qiaFpen8ZMNrEFRwMOf8gibNykdkcuude7YmdFC1GQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"display: flex;flex-flow: row nowrap;margin: 10px 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-bottom: 3px solid rgb(242, 183, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;align-self: flex-start;height: auto;padding-bottom: 3px;\">\n<section style=\"text-align: justify;font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u770b\u6765\u53c8\u5230\u89e3\u8bfb\u65f6\u95f4\u4e86\u2014\u2014<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\">\u5982\u4e0a\u56fe\uff0c\u63cf\u8ff0\u7684\u4fe1\u606f\u4e3a\uff1aRIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY \u901a\u8def\u5728A\u7ec4\u4e0a\u8c03\uff08\u663e\u8457\u5bcc\u96c6\u5728 A \u7684\u9876\u7aef\uff09\uff0c\u7136\u540e\u662f\u5426\u663e\u8457\u5462\uff1f\u540e\u9762\u7684 ES\u3001NES\u3001pval\u3001FDR \u7b49\u7edf\u8ba1\u503c\u7ed9\u51fa\u4e86\u7b54\u6848\u3002<br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5898148148148148\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_3pMrzqlT59EaZhNKhBELia5hQHPU3A.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhtt3XNjEI15zdBwiadlkZlcEVpX3pMrzqlT59EaZhNKhBELia5hQHPU3A\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"display: flex;flex-flow: row nowrap;margin: 10px 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-bottom: 3px solid rgb(242, 183, 183);border-bottom-right-radius: 0px;flex: 0 0 auto;align-self: flex-start;height: auto;padding-bottom: 3px;\">\n<section style=\"text-align: justify;font-size: 18px;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>\u518d\u63a5\u518d\u5389\u2014\u2014<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5982\u4e0a\u56fe\uff0c\u5bcc\u96c6\u56fe\u4e00\u5171\u5206\u4e3a\u4e0a\u4e2d\u4e0b 3 \u90e8\u5206\uff1a<br \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u7b2c\u4e00\u90e8\u5206 ES \u6298\u7ebf\u56fe\uff1a<\/strong>\u663e\u793a\u4e86\u5f53\u5206\u6790\u6cbf\u7740\u6392\u5e8f\u57fa\u56e0\u96c6\u6309\u6392\u5e8f\u8ba1\u7b97\u65f6\uff0cES \u503c\u5728\u8ba1\u7b97\u5230\u6bcf\u4e2a\u4f4d\u7f6e\u65f6\u7684\u5c55\u793a\u3002\u6700\u9ad8\u5cf0\u5904\u7684ES\u5f97\u5206\u662f\u57fa\u56e0\u96c6\u7684 ES \u503c\u3002<\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u7b2c\u4e8c\u90e8\u5206 hits \u56fe\uff1a<\/strong>\u4fd7\u79f0\u6761\u5f62\u7801\u56fe\uff0c\u7528\u7ebf\u6761\u6216\u8005 hit \u6807\u8bb0\u4e86\u901a\u8def\u57fa\u56e0\u96c6\u4e2d\u6210\u5458\u51fa\u73b0\u5728\u57fa\u56e0\u6392\u5e8f\u5217\u8868\u4e2d\u7684\u4f4d\u7f6e\u3002leading edge subset \u5c31\u662f\uff080,0\uff09\u5230\u7eff\u8272\u66f2\u7ebf\u5cf0\u503c ES \u51fa\u73b0\u5bf9\u5e94\u7684\u8fd9\u90e8\u5206\u57fa\u56e0\uff08x\u8f740\u5230\u865a\u7ebf\u90a3\u90e8\u5206\uff09\u3002<\/p>\n<p style=\"white-space: normal;\">\u6240\u8c13Leading-edge subset\uff0c\u5c31\u662f\u5bf9\u5bcc\u96c6\u5f97\u5206\u8d21\u732e\u6700\u5927\u7684\u57fa\u56e0\u6210\u5458\u3002\u5982\u679cES\u5f97\u5206\u90fd\u662f\u6b63\u503c\uff08\u5982\u4e0a\u56fe\u6240\u793a\uff09\uff0c\u90a3\u4e48Leading-edge subset\u5c31\u5728\u5cf0\u503cES\u7684\u5de6\u4fa7\uff0c\u53cd\u4e4b\u5219\u5728\u53f3\u4fa7\uff08\u5e95\u90e8\u5bcc\u96c6 = A\/C \u4e0b\u8c03\u8868\u8fbe = C\u7ec4\u9ad8\u8868\u8fbe\uff09\u3002\u90a3\u4e48\u6839\u636e\u672c\u56fe\u6211\u4eec\u5f88\u5bb9\u6613\u770b\u51fa\uff0c\u8be5\u901a\u8def\u5728 A \u7ec4\u9ad8\u8868\u8fbe\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\"><strong>\u7b2c\u4e09\u90e8\u5206\u662f\u6392\u5e8f\u540e\u6240\u6709\u57fa\u56e0 rank \u503c\u7684\u5206\u5e03<\/strong>\uff0c\u70ed\u56fe\u7ea2\u8272\u90e8\u5206\u5bf9\u5e94\u7684\u57fa\u56e0\u5728 A \u7ec4\u9ad8\u8868\u8fbe\uff0c\u84dd\u8272\u90e8\u5206\u5bf9\u5e94\u7684\u57fa\u56e0\u5728 C\u7ec4\u9ad8\u8868\u8fbe\uff0c\u6bcf\u4e2a\u57fa\u56e0\u5bf9\u5e94\u7684\u4fe1\u566a\u6bd4\uff08Signal2noise\uff0c\u524d\u9762\u9009\u62e9\u7684\u6392\u5e8f\u503c\u8ba1\u7b97\u65b9\u5f0f\uff09\u4ee5\u7070\u8272\u9762\u79ef\u56fe\u5c55\u793a\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6435185185185185\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_y7ibNAsBwf38ZsMz3m7icicflqIPTA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhvVUjLDpPUaf945BDNicgeXwVEPlZy7ibNAsBwf38ZsMz3m7icicflqIPTA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9453703703703704\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_aO0nTPhtKeDqABafhYTygH1mGRHYEg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhF4OhbPzVxjz8UQEMZCLrMWTfiaO0nTPhtKeDqABafhYTygH1mGRHYEg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u7ed3\u679c\u4e2d\u8be6\u7ec6\u7ed9\u51fa\u4e86\u8be5\u57fa\u56e0\u96c6\u4e0b\u5305\u542b\u7684\u57fa\u56e0\u7684\u5177\u4f53\u4fe1\u606f\u548c\u524d100\u4e2a\u57fa\u56e0\u4f7f\u7528\u70ed\u56fe\u8fdb\u884c\u5c55\u793a\u3002<br \/><\/p>\n<p style=\"white-space: normal;\"><br \/><\/p>\n<p style=\"white-space: normal;\">\u770b\u8fc7\u5c0f\u56fe\u7684\u89e3\u8bfb\u540e\u662f\u4e0d\u662f\u53d1\u73b0GSEA\u4e5f\u4e0d\u8fc7\u5982\u6b64\uff1f\u4e0b\u8bfe\u540e\u8d76\u7d27\u884c\u52a8\u8d77\u6765\u8ba9\u5c0f\u56fe\u770b\u770b\u5927\u5bb6\u7684\u5b66\u4e60\u6210\u679c\uff0c\u6b22\u8fce\u5728\u8bc4\u8bba\u533a\u4e00\u8d77\u8ba8\u8bba\uff01<\/p>\n<\/section>\n<p style=\"white-space: normal;\" powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;border-color: rgb(176, 176, 176);padding: 7px;\">\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: rgba(249, 238, 237, 0.5);padding: 18px;\">\n<section style=\"\" powered-by=\"xiumi.us\">\n<section style=\"text-align: justify;font-size: 14px;\">\n<p style=\"white-space: normal;\">\u6709\u5174\u8da3\u7684\u670b\u53cb\u53ef\u4ee5\u7ee7\u7eed\u5173\u6ce8\u5c0f\u56fe\u7684\u5fae\u4fe1\u516c\u4f17\u53f7\uff08\u751f\u4fe1\u56fe\uff09\u548c\u4f7f\u7528\u4e91\u751f\u4fe1\u751f\u7269\u4fe1\u606f\u5b66\u5e73\u53f0\u8fdb\u884c\u96f6\u4ee3\u7801\u5206\u6790\u3002\u6211\u4eec\u4e0b\u671f\u518d\u89c1~<\/p>\n<p style=\"white-space: normal;\">\u6b22\u8fce\u4f7f\u7528\uff1a\u4e91\u751f\u4fe1\u5e73\u53f0 ( http:\/\/www.biocloudservice.com\/home.html)<\/p>\n<\/section>\n<\/section>\n<section style=\"transform: scale(0.5);transform-origin: center center;margin-top: -65px;margin-bottom: -65px;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_VAvCWAzbEQawQ0VkKASfFbekK48tKw.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/2wJ7bWfS0Qus89ZkibCnWkhoHp3TL3VZhZtZzJd7O7sqaSKCSAFeHbvJFVAvCWAzbEQawQ0VkKASfFbekK48tKw\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"258\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:28.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:28.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;background-color: rgb(249, 174, 165);padding: 10px 0px;\" width=\"96.3700%\">\n<section style=\"line-height: 1;text-align: center;font-size: 17px;color: rgb(255, 255, 255);letter-spacing: 5px;\" powered-by=\"xiumi.us\">\n<p><strong>\u5f80\u671f\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:28.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:28.classicTable1:1.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<p powered-by=\"xiumi.us\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247483741&idx=1&sn=39674bd0f28be4148fa07665bb9c0636&chksm=c1b17ca0f6c6f5b6cf63b01fdde27d73e61d5f8cfa2cddf644b400a32c6489de27a83b5b0b10&scene=21#wechat_redirect\" textvalue=\"Volcano plot\u2014\u2014\u522b\u518d\u95ee\u6211\u8fd9\u4e3a\u4ec0\u4e48\u662f\u706b\u5c71\u56fe\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\"><span style=\"letter-spacing: 0.034em;\">Volcano plot<\/span><span style=\"letter-spacing: 0.034em;\">\u2014\u2014<\/span><span style=\"letter-spacing: 0.034em;\">\u522b\u518d\u95ee\u6211\u8fd9\u4e3a\u4ec0\u4e48\u662f\u706b\u5c71\u56fe<\/span><\/a><span style=\"letter-spacing: 0.034em;\"><\/span><\/p>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:28.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:28.classicTable1:2.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: middle;border-width: 0px;align-self: center;flex: 0 0 auto;\">\n<p powered-by=\"xiumi.us\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&mid=2247483730&idx=1&sn=abc7095012e15da0a0c27ec4d79ec243&chksm=c1b17caff6c6f5b93c5fc3b02da32d7e65aaf6063f50cde671373bf81595115c30ae0235ffb1&scene=21#wechat_redirect\" textvalue=\"GSEA\u5bcc\u96c6\u5206\u6790\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">GSEA\u5bcc\u96c6\u5206\u6790<\/a><\/p>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:28.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:28.classicTable1:3.td@@0\" style=\"border-top: 0px none rgb(62, 62, 62);border-right: 0px none rgb(62, 62, 62);border-left: 0px none rgb(62, 62, 62);border-bottom-color: rgb(202, 198, 198);border-bottom-style: dashed;background-color: rgb(247, 247, 247);padding-right: 5px;padding-left: 5px;\" width=\"96.3700%\">\n<section style=\"text-align: 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