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(MeTIL)\u5f97\u5206\uff0c\u5e76\u6839\u636e\u514d\u75ab\u68c0\u67e5\u70b9\u8868\u8fbe\u548c\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u5bcc\u96c6\u7ed8\u5236\u70ed\u56fe\u3002\u53ef\u4ee5\u901a\u8fc7\u4e0a\u4f20\u81ea\u6709\u6570\u636e\u8fdb\u884c\u5206\u6790\u5566\uff0c\u6570\u636e\u6a21\u677f\u53ef\u4ee5\u53c2\u8003\u5de6\u4e0a\u89d2~<\/span><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\"><br \/><\/span><\/p>\n<p style=\"text-align:center;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.3470533208606174\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_MwXjmoAy9TQkxroR6tw7uuYpTW15xQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZy15VIVVOS8NZGzAqibiaYErFRCMwXjmoAy9TQkxroR6tw7uuYpTW15xQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1069\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\"><br \/><\/span><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u8fd9\u662f\u4e0a\u4f20\u6570\u636e\u754c\u9762\uff1a<\/span><\/p>\n<p style=\"text-align:center;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.29542302357836336\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_4Qnxm8hlzm2jW048DurZZl22THmqoA-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZV6Dv70xK1p8B0ExDz9CwF0h04Qnxm8hlzm2jW048DurZZl22THmqoA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"721\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u3010\u6ce8\u610f\u3011<\/span><\/p>\n<\/section>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">1. \u5bf9\u53c2\u6570\u8fdb\u884c\u8bbe\u7f6e\u3002\u8fd9\u91cc\uff0c\u5fc5\u987b\u8f93\u5165\u53c2\u6570\u6709 4 \u4e2a\u662f-ann,-met,-Exp \u548c sign,ann \u8868<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u793a\u4e9a\u578b\u6ce8\u91ca\u4fe1\u606f\uff1bmet \u8868\u793a\u7532\u57fa\u5316\u6570\u636e\uff1bExp \u8868\u793a\u8868\u8fbe\u77e9\u9635\uff1bsign \u8868\u793a\u514d\u75ab\u7b7e\u540d\u6587\u4ef6\u3002<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">2. \u70b9\u51fb\u4e0a\u4f20\u6570\u636e \u8f93\u5165***\u6587\u4ef6\uff0c\u8f93\u5165\u7684\u6587\u4ef6\u540d\u5fc5\u987b\u548c\u793a\u4f8b\u6587\u4ef6\u540d\u4e00\u81f4\uff0c\u4e14\u90fd\u662f\u82f1\u6587\u65e0\u7279\u6b8a\u5b57\u7b26\u3002\u5982\u679c\u4f7f\u7528\u81ea\u6709\u6570\u636e\u65f6\uff0c\u9700\u6ce8\u610f\u6587\u4ef6\u540d\u548c\u5bf9\u5e94\u7684\u5185\u5bb9\u8981\u5339\u914d\uff0c\u4ee5\u53ca\u8f93\u5165\u6570\u636e\u91cc\u7684\u884c\u540d\u5217\u540d\u7b49\u7b49\u3002<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">3. \u5982\u6709\u975e\u6587\u4ef6\u7c7b\u53c2\u6570\uff0c\u70b9\u51fb \u8f93\u5165\u53c2\u6570\u5bf9\u5e94\u7684\u503c,\u9ed8\u8ba4\u6bd4\u5982 pvalue\u503c\u662f0.05 gene\u503c\u662f TP53.<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><br \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u5c0f\u679c\u5e26\u5927\u5bb6\u4e00\u8d77\u770b\u770b\u7ed3\u679c\u5982\u4f55\u5427\uff1a<\/span><\/p>\n<p style=\"text-align:center;letter-spacing: 0.578px;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.8447937131630648\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_fD8kIdnicLOyYuKwibzpjK7ia6iajg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZTrsIwvJ8Q6ia5EPNYuCVNxCUJzLaIfD8kIdnicLOyYuKwibzpjK7ia6iajg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"509\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">1. TCGA_log2TPM_hugo.txt<\/span><\/p>\n<p style=\"text-align:center;letter-spacing: 0.578px;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.17777777777777778\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_okjoY5q4ZlN7cgumic7APTPAicvWag-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZaGhQHvm2NavPUTJQXFkibL9ko62okjoY5q4ZlN7cgumic7APTPAicvWag\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u6ce8\uff1a\u7ecf\u8fc7 log2\u5904\u7406\u8fc7\u7684\u8868\u8fbe\u77e9\u9635\u3002<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><br \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">2. TCGA_log2TPM_hugo_ESTIMATE.txt<\/span><\/p>\n<p style=\"text-align:center;letter-spacing: 0.578px;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.34658511722731905\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_8tQNDgprPGujPPrVcqMnnicWE3umTg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZ2zDBSc31kl8PQDJesxqpTEHl78tQNDgprPGujPPrVcqMnnicWE3umTg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"981\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u6ce8\uff1a\u7ecf\u8fc7\u683c\u5f0f\u8f6c\u5316\u7684\u8868\u8fbe\u77e9\u9635\uff0c\u589e\u52a0\u4e86\u4e00\u5217 Description<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><br \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">3. TCGA_log2TPM_hugo_estimate_score.txt<\/span><\/p>\n<p style=\"text-align:center;letter-spacing: 0.578px;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.3494845360824742\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_2nnfPmYHXDNByOEkP0OScR88RTuZuA-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZS9UahdZxCg5iczvFoPOTacZyl2nnfPmYHXDNByOEkP0OScR88RTuZuA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"970\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u6ce8\uff1a\u8ba1\u7b97 immune\/stromal<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><br \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">4. TIME.pdf<\/span><\/p>\n<p style=\"text-align:center;letter-spacing: 0.578px;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"1.02863436123348\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_ibyAhu3nFlaJcYeOBLmKpGiaupoPEQ-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZKE6OZABdswz3Sn950d4jH3hELoibyAhu3nFlaJcYeOBLmKpGiaupoPEQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"454\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u6ce8\uff1a\u6a2a\u5750\u6807\u8868\u793a\u4e0d\u540c\u7684\u80bf\u7624\u6837\u672c\uff1b<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">ImmuneScore\u662f\u8bc4\u4f30\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u7a0b\u5ea6\u7684\u6307\u6807\uff1b<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">StromalScore\u662f\u4e00\u79cd\u8861\u91cf\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u95f4\u8d28\u6210\u5206\u6bd4\u4f8b\u7684\u6307\u6807\uff1b<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">CMOIC \u662f\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u514d\u75ab\u7ec6\u80de\u4e0e\u80bf\u7624\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u4e00\u4e2a\u8ba1\u7b97\u6a21\u578b\uff0cCS1-4\u662f\u56db\u79cd\u514d\u75ab\u68c0\u67e5\u70b9\uff1b<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">TIME\u662f\u6307\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\uff1b<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">MeTIL\u5f97\u5206\u662f\u8861\u91cf\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\uff0c\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u7684DNA\u7532\u57fa\u5316\u6c34\u5e73\u7684\u4e00\u4e2a\u6307\u6807\u3002<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\"><br \/><\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u770b\u4e86\u5c0f\u679c\u7684\u4ecb\u7ecd\u662f\u4e0d\u662f\u60f3\u8981\u8feb\u4e0d\u53ca\u5f85\u5730\u8bd5\u4e00\u4e0b\u4e86\u5462\uff1f<\/span><\/p>\n<section style=\"margin-bottom: 0px;letter-spacing: 0.578px;white-space: normal;font-size: 16px;\">\n<section>\n<section powered-by=\"xiumi.us\">\n<p style=\"text-align: center;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"105054\" style=\"margin-bottom: 0px;letter-spacing: 0.578px;white-space: normal;font-size: 16px;\">\n<section style=\"margin: 10px auto;text-align: center;\">\n<section style=\"padding-top: 30px;padding-bottom: 30px;background-color: rgb(242, 246, 255);border-radius: 7px;\">\n<section style=\"display: flex;justify-content: space-evenly;align-items: center;\">\n<section data-width=\"26%\" style=\"width: 150.266px;\">\n<section style=\"padding: 7px;border-radius: 15px;box-shadow: rgba(169, 187, 223, 0.45) 4px 4px 8px, rgb(255, 255, 255) -2.5px -2.5px 5px;\">\n<section data-width=\"100%\" style=\"width: 136.266px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"136\" data-cropsely1=\"0\" data-cropsely2=\"137\" data-ratio=\"1\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_jEYQoRbKh3HUg3IGgzymibpTnmaM6Q.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAwIX3hF1ZZeqvXLknM5Oq7CDG9YFpmvU1ge12vc3NvibhViceQjEYQoRbKh3HUg3IGgzymibpTnmaM6Q\/640?wx_fmt=jpeg'\" data-type=\"png\" data-w=\"430\" data-width=\"100%\" style=\"height: 137px;vertical-align: inherit;width: 137px;display: block;border-radius: 7px;\" title=\"\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801.png\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<section data-width=\"62%\" style=\"width: 358.359px;\">\n<section style=\"display: inline-block;\">\n<section style=\"padding: 7px 15px;border-radius: 20px;box-shadow: rgba(169, 187, 223, 0.45) 6px 6px 8px inset, rgb(255, 255, 255) -2.5px -2.5px 5px inset;\">\n<section data-brushtype=\"text\" style=\"font-size: 14px;letter-spacing: 1.5px;color: rgb(111, 133, 172);\">\n<p style=\"text-indent: 0em;line-height: 1.75em;\"><span style=\"letter-spacing: 0.5px;\"><span style=\"letter-spacing: 1.5px;\">\u626b\u7801\u52a0\u5c0f\u679c<\/span><\/span><\/p>\n<p style=\"text-indent: 0em;line-height: 1.75em;\"><span style=\"letter-spacing: 0.5px;\"><span style=\"letter-spacing: 1.5px;\">\u9886\u53d6\u751f\u4fe1\u5927\u793c\u5305<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-bottom: 0px;letter-spacing: 0.578px;white-space: normal;caret-color: rgba(0, 0, 0, 0);font-size: 16px;\">\n<section>\n<section style=\"margin-top: 0.5em;\">\n<section style=\"padding: 0.5em;border-width: 1px;border-style: solid;box-shadow: rgb(226, 226, 226) 0px 16px 1px -13px;border-color: rgb(0, 150, 136);\">\n<section style=\"text-align: left;\">\n<section style=\"color: rgb(255, 129, 36);text-align: justify;\">\n<section style=\"margin-bottom: 8px;\">\n<p style=\"text-indent: 0em;line-height: 1.75em;\"><span style=\"letter-spacing: 0.5px;\">\u70b9\u51fb<strong><span style=\"color: rgb(0, 150, 136);\">\u201c\u9605\u8bfb\u539f\u6587\u201d<\/span><\/strong>\u7acb\u523b\u62e5\u6709<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-bottom: 8px;font-size: 32px;color: rgb(0, 150, 136);\">\n<p style=\"text-indent: 0em;line-height: 1.75em;\"><span style=\"letter-spacing: 0.5px;\">\u2193\u2193\u2193<\/span><span style=\"letter-spacing: 0.5px;text-indent: 0em;\"><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"display: none;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<div class=\"msg_source_url\"><a href=\"http:\/\/www.biocloudservice.com\/home.html\" target=\"_blank\" rel=\"noopener\">\u9605\u8bfb\u539f\u6587<\/a><\/div>\n<p><\/content><\/p>\n<div class=\"msg_source_url\"><a 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1.5em;\">\u563f\u5927\u5bb6\uff01\u597d\u4e45\u4e0d\u89c1\uff0c\u4eca\u5929\u6211\u4eec\u6765\u5b66\u4e60\u4e00\u4e2a\u65b0\u7684R\u5305\uff0c\u5b83\u53ef\u4ee5\u7528\u6765\u8fdb\u884c\u514d\u75ab\u5f97\u5206\u7684\u8ba1\u7b97\uff0c\u5e76\u7ed8\u5236\u7bb1\u7ebf\u56fe\u8fdb\u884c\u7ed3\u679c\u5c55\u793a\u3002\u611f\u5174\u8da3\u7684\u8bdd\u5c31\u548c\u5c0f\u679c\u4e00\u8d77\u5b66\u8d77\u6765\u5427\uff01<\/span><\/p>\n<p style=\"text-align:justify;text-indent: 0em;line-height: 1.75em;\"><span style=\"font-size: 14px;letter-spacing: 0.5px;line-height: 2em;\"><span style=\"font-family: \u5b8b\u4f53;\"><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<section style=\"height: 0px;overflow: hidden;\"><br \/><\/section>\n<section>\n<section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;text-align: center;height: 0px;overflow: hidden;\"><br \/><\/section>\n<section>\n<section style=\"margin-bottom: 8px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;caret-color: red;\">\u5728\u80bf\u7624\u514d\u75ab\u73af\u5883\u5bcc\u96c6\u5206\u6790\u4e2d\uff0cDNA\u7532\u57fa\u5316\u6c34\u5e73\u53ef\u4ee5\u7528\u6765\u63a8\u65ad\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u7684\u8868\u8fbe\u60c5\u51b5\u548c\u529f\u80fd\u72b6\u6001\u3002\u4f8b\u5982\uff0c\u5982\u679c\u67d0\u4e2a\u57fa\u56e0\u7684\u542f\u52a8\u5b50\u533a\u57dfCpG\u5c9b\u4e0a\u7684\u7532\u57fa\u5316\u6c34\u5e73\u8f83\u9ad8\uff0c\u5c31\u610f\u5473\u7740\u8be5\u57fa\u56e0\u5728\u8be5\u6837\u672c\u4e2d\u88ab\u6c89\u9ed8\u6216\u8868\u8fbe\u4e0b\u8c03\u3002\u76f8\u53cd\uff0c\u5982\u679c\u67d0\u4e2a\u57fa\u56e0\u7684\u542f\u52a8\u5b50\u533a\u57dfCpG\u5c9b\u4e0a\u7684\u7532\u57fa\u5316\u6c34\u5e73\u8f83\u4f4e\uff0c\u5c31\u610f\u5473\u7740\u8be5\u57fa\u56e0\u5728\u8be5\u6837\u672c\u4e2d\u88ab\u6fc0\u6d3b\u6216\u8868\u8fbe\u4e0a\u8c03\u3002<\/span><\/section>\n<section style=\"letter-spacing: 0.578px;\">\n<p><br \/><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u514d\u75ab\u8868\u8fbe\u548c\u80bf\u7624\u514d\u75ab\u73af\u5883\u5bcc\u96c6\u5206\u6790\u7528\u4e8e\u7814\u7a76\u80bf\u7624\u7ec4\u7ec7\u4e2d\u4e0e\u514d\u75ab\u76f8\u5173\u7684\u57fa\u56e0\u8868\u8fbe\u6c34\u5e73\u53ca\u5176\u5173\u8054\u7684\u751f\u7269\u5b66\u8fc7\u7a0b\uff0c\u5176\u7ed3\u679c\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u66f4\u597d\u5730\u4e86\u89e3\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u673a\u5236\uff0c\u5e76\u4e3a\u4e34\u5e8a\u6cbb\u7597\u63d0\u4f9b\u6307\u5bfc\u3002<\/span><\/p>\n<p><br \/><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u4e91\u751f\u4fe1\u5e73\u53f0\u63d0\u4f9b\u4e86\u7ebf\u4e0a\u7684\u514d\u75ab\u8868\u8fbe\u548c\u80bf\u7624\u514d\u75ab\u73af\u5883\u5bcc\u96c6\u5206\u6790\uff0c\u5b83\u6839\u636e\u7532\u57fa\u5316\u8ba1\u7b97 DNA methylation of tumour-infiltrating lymphocyte (MeTIL)\u5f97\u5206\uff0c\u5e76\u6839\u636e\u514d\u75ab\u68c0\u67e5\u70b9\u8868\u8fbe\u548c\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u5bcc\u96c6\u7ed8\u5236\u70ed\u56fe\u3002\u53ef\u4ee5\u901a\u8fc7\u4e0a\u4f20\u81ea\u6709\u6570\u636e\u8fdb\u884c\u5206\u6790\u5566\uff0c\u6570\u636e\u6a21\u677f\u53ef\u4ee5\u53c2\u8003\u5de6\u4e0a\u89d2~<\/span><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\"><br \/><\/span><\/p>\n<p style=\"text-align:center;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.3470533208606174\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_MwXjmoAy9TQkxroR6tw7uuYpTW15xQ.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZy15VIVVOS8NZGzAqibiaYErFRCMwXjmoAy9TQkxroR6tw7uuYpTW15xQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1069\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\"><br \/><\/span><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u8fd9\u662f\u4e0a\u4f20\u6570\u636e\u754c\u9762\uff1a<\/span><\/p>\n<p style=\"text-align:center;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.29542302357836336\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_4Qnxm8hlzm2jW048DurZZl22THmqoA-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZV6Dv70xK1p8B0ExDz9CwF0h04Qnxm8hlzm2jW048DurZZl22THmqoA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"721\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u3010\u6ce8\u610f\u3011<\/span><\/p>\n<\/section>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">1. \u5bf9\u53c2\u6570\u8fdb\u884c\u8bbe\u7f6e\u3002\u8fd9\u91cc\uff0c\u5fc5\u987b\u8f93\u5165\u53c2\u6570\u6709 4 \u4e2a\u662f-ann,-met,-Exp \u548c sign,ann \u8868<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u793a\u4e9a\u578b\u6ce8\u91ca\u4fe1\u606f\uff1bmet \u8868\u793a\u7532\u57fa\u5316\u6570\u636e\uff1bExp \u8868\u793a\u8868\u8fbe\u77e9\u9635\uff1bsign \u8868\u793a\u514d\u75ab\u7b7e\u540d\u6587\u4ef6\u3002<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">2. \u70b9\u51fb\u4e0a\u4f20\u6570\u636e \u8f93\u5165***\u6587\u4ef6\uff0c\u8f93\u5165\u7684\u6587\u4ef6\u540d\u5fc5\u987b\u548c\u793a\u4f8b\u6587\u4ef6\u540d\u4e00\u81f4\uff0c\u4e14\u90fd\u662f\u82f1\u6587\u65e0\u7279\u6b8a\u5b57\u7b26\u3002\u5982\u679c\u4f7f\u7528\u81ea\u6709\u6570\u636e\u65f6\uff0c\u9700\u6ce8\u610f\u6587\u4ef6\u540d\u548c\u5bf9\u5e94\u7684\u5185\u5bb9\u8981\u5339\u914d\uff0c\u4ee5\u53ca\u8f93\u5165\u6570\u636e\u91cc\u7684\u884c\u540d\u5217\u540d\u7b49\u7b49\u3002<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">3. \u5982\u6709\u975e\u6587\u4ef6\u7c7b\u53c2\u6570\uff0c\u70b9\u51fb \u8f93\u5165\u53c2\u6570\u5bf9\u5e94\u7684\u503c,\u9ed8\u8ba4\u6bd4\u5982 pvalue\u503c\u662f0.05 gene\u503c\u662f TP53.<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><br \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u5c0f\u679c\u5e26\u5927\u5bb6\u4e00\u8d77\u770b\u770b\u7ed3\u679c\u5982\u4f55\u5427\uff1a<\/span><\/p>\n<p style=\"text-align:center;letter-spacing: 0.578px;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.8447937131630648\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_fD8kIdnicLOyYuKwibzpjK7ia6iajg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZTrsIwvJ8Q6ia5EPNYuCVNxCUJzLaIfD8kIdnicLOyYuKwibzpjK7ia6iajg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"509\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">1. TCGA_log2TPM_hugo.txt<\/span><\/p>\n<p style=\"text-align:center;letter-spacing: 0.578px;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.17777777777777778\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_okjoY5q4ZlN7cgumic7APTPAicvWag-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZaGhQHvm2NavPUTJQXFkibL9ko62okjoY5q4ZlN7cgumic7APTPAicvWag\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u6ce8\uff1a\u7ecf\u8fc7 log2\u5904\u7406\u8fc7\u7684\u8868\u8fbe\u77e9\u9635\u3002<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><br \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">2. TCGA_log2TPM_hugo_ESTIMATE.txt<\/span><\/p>\n<p style=\"text-align:center;letter-spacing: 0.578px;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.34658511722731905\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_8tQNDgprPGujPPrVcqMnnicWE3umTg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZ2zDBSc31kl8PQDJesxqpTEHl78tQNDgprPGujPPrVcqMnnicWE3umTg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"981\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u6ce8\uff1a\u7ecf\u8fc7\u683c\u5f0f\u8f6c\u5316\u7684\u8868\u8fbe\u77e9\u9635\uff0c\u589e\u52a0\u4e86\u4e00\u5217 Description<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><br \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">3. TCGA_log2TPM_hugo_estimate_score.txt<\/span><\/p>\n<p style=\"text-align:center;letter-spacing: 0.578px;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"0.3494845360824742\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_2nnfPmYHXDNByOEkP0OScR88RTuZuA-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZS9UahdZxCg5iczvFoPOTacZyl2nnfPmYHXDNByOEkP0OScR88RTuZuA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"970\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u6ce8\uff1a\u8ba1\u7b97 immune\/stromal<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><br \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">4. TIME.pdf<\/span><\/p>\n<p style=\"text-align:center;letter-spacing: 0.578px;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-ratio=\"1.02863436123348\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_ibyAhu3nFlaJcYeOBLmKpGiaupoPEQ-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/zcicibWZessAyhg8icSDEe6yrt3jEHKQFJZKE6OZABdswz3Sn950d4jH3hELoibyAhu3nFlaJcYeOBLmKpGiaupoPEQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"454\" style=\"width: 100%;\" data-recalc-dims=\"1\" \/><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u6ce8\uff1a\u6a2a\u5750\u6807\u8868\u793a\u4e0d\u540c\u7684\u80bf\u7624\u6837\u672c\uff1b<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">ImmuneScore\u662f\u8bc4\u4f30\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u7a0b\u5ea6\u7684\u6307\u6807\uff1b<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">StromalScore\u662f\u4e00\u79cd\u8861\u91cf\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u95f4\u8d28\u6210\u5206\u6bd4\u4f8b\u7684\u6307\u6807\uff1b<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">CMOIC \u662f\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u514d\u75ab\u7ec6\u80de\u4e0e\u80bf\u7624\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u4e00\u4e2a\u8ba1\u7b97\u6a21\u578b\uff0cCS1-4\u662f\u56db\u79cd\u514d\u75ab\u68c0\u67e5\u70b9\uff1b<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">TIME\u662f\u6307\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\uff1b<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">MeTIL\u5f97\u5206\u662f\u8861\u91cf\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\uff0c\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u7684DNA\u7532\u57fa\u5316\u6c34\u5e73\u7684\u4e00\u4e2a\u6307\u6807\u3002<\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\"><br \/><\/span><\/p>\n<p style=\"text-align:justify;letter-spacing: 0.578px;\"><span style=\"font-size: 14px;letter-spacing: 0.578px;line-height: 1.57em;\">\u770b\u4e86\u5c0f\u679c\u7684\u4ecb\u7ecd\u662f\u4e0d\u662f\u60f3\u8981\u8feb\u4e0d\u53ca\u5f85\u5730\u8bd5\u4e00\u4e0b\u4e86\u5462\uff1f<\/span><\/p>\n<section style=\"margin-bottom: 0px;letter-spacing: 0.578px;white-space: normal;font-size: 16px;\">\n<section>\n<section powered-by=\"xiumi.us\">\n<p style=\"text-align: center;\"><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"105054\" style=\"margin-bottom: 0px;letter-spacing: 0.578px;white-space: normal;font-size: 16px;\">\n<section style=\"margin: 10px auto;text-align: center;\">\n<section style=\"padding-top: 30px;padding-bottom: 30px;background-color: rgb(242, 246, 255);border-radius: 7px;\">\n<section style=\"display: flex;justify-content: space-evenly;align-items: center;\">\n<section data-width=\"26%\" style=\"width: 150.266px;\">\n<section style=\"padding: 7px;border-radius: 15px;box-shadow: rgba(169, 187, 223, 0.45) 4px 4px 8px, rgb(255, 255, 255) -2.5px -2.5px 5px;\">\n<section data-width=\"100%\" style=\"width: 136.266px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"136\" data-cropsely1=\"0\" data-cropsely2=\"137\" data-ratio=\"1\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_jEYQoRbKh3HUg3IGgzymibpTnmaM6Q.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAwIX3hF1ZZeqvXLknM5Oq7CDG9YFpmvU1ge12vc3NvibhViceQjEYQoRbKh3HUg3IGgzymibpTnmaM6Q\/640?wx_fmt=jpeg'\" data-type=\"png\" data-w=\"430\" data-width=\"100%\" style=\"height: 137px;vertical-align: inherit;width: 137px;display: block;border-radius: 7px;\" title=\"\u5c0f\u4e91-\u5fae\u4fe1\u4e8c\u7ef4\u7801.png\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<section data-width=\"62%\" style=\"width: 358.359px;\">\n<section style=\"display: inline-block;\">\n<section style=\"padding: 7px 15px;border-radius: 20px;box-shadow: rgba(169, 187, 223, 0.45) 6px 6px 8px inset, rgb(255, 255, 255) -2.5px -2.5px 5px inset;\">\n<section data-brushtype=\"text\" style=\"font-size: 14px;letter-spacing: 1.5px;color: rgb(111, 133, 172);\">\n<p style=\"text-indent: 0em;line-height: 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