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style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.37130801687763715\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_c2Cqd0kJeKHDAic3qjBic0Lj2rzIJg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPHEhGT1F6DI6EgqcycfCWFBHGZQc2Cqd0kJeKHDAic3qjBic0Lj2rzIJg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"948\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#install.packages(\"BiocManager\")<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#BiocManager::install('ConsensusClusterPlus')#\u5c0f\u4f19\u4f34\u6ca1\u6709\u7684\u81ea\u5df1\u8981\u4e0b\u8f7d\u4e00\u4e0b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">library(tidyverse)<\/span><\/code><code><span class=\"code-snippet_outer\">library(ConsensusClusterPlus)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5bfc\u5165\u6570\u636e<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">exp <- read.table(<span class=\"code-snippet__string\">\"text1.txt\"<\/span>,sep = <span class=\"code-snippet__string\">\"t\"<\/span>,row.names = <span class=\"code-snippet__number\">1<\/span>,check.names = <span class=\"code-snippet__built_in\">F<\/span>,stringsAsFactors = <span class=\"code-snippet__built_in\">F<\/span>,header = <span class=\"code-snippet__built_in\">T<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">d=as.matrix(<span class=\"code-snippet__built_in\">exp<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">gene <- <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"MMP9\"<\/span>,<span class=\"code-snippet__string\">\"CCND1\"<\/span>,<span class=\"code-snippet__string\">\"STAT1\"<\/span>,<span class=\"code-snippet__string\">\"AR\"<\/span>,<span class=\"code-snippet__string\">\"AKR1C3\"<\/span>,<span class=\"code-snippet__string\">\"GSTP1\"<\/span>,<span class=\"code-snippet__string\">\"PGR\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">d <- d[gene,]<\/span><\/code><code><span class=\"code-snippet_outer\">mads=apply(d,<span class=\"code-snippet__number\">1<\/span>,mad)<\/span><\/code><code><span class=\"code-snippet_outer\">d=d[rev(order(mads))[<span class=\"code-snippet__number\">1<\/span>:<span class=\"code-snippet__number\">7<\/span>],] <span class=\"code-snippet__comment\">#7\u662f\u57fa\u56e0\u4e2a\u6570<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">d = sweep(d,<span class=\"code-snippet__number\">1<\/span>, apply(d,<span class=\"code-snippet__number\">1<\/span>,median,na.rm=<span class=\"code-snippet__built_in\">T<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">title=(<span class=\"code-snippet__string\">\"JULEI\"<\/span>) <span class=\"code-snippet__comment\">##\u6587\u4ef6\u5939\u8f93\u51fa\u56fe\u7247\u7684\u4f4d\u7f6e<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">set.seed(<span class=\"code-snippet__number\">1<\/span>) <span class=\"code-snippet__comment\">#\u6211\u53d1\u73b0\u8bbe\u4e0d\u8bbe\u7f6e\u79cd\u5b50\u90fd\u4e00\u6837<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8fd9\u91cc\u5c0f\u82b1\u9009\u53d6\u81ea\u5df1\u7684\u793a\u4f8b\u6570\u636e\uff0c\u5c0f\u4f19\u4f34\u4eec\u6574\u7406\u81ea\u5df1\u60f3\u53bb\u805a\u7c7b\u7684\u57fa\u56e0\u3002<\/span><\/span><\/code><\/pre>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u7136\u540e\u6211\u4eec\u6253\u5f00JULEI\u8fd9\u4e2a\u6587\u4ef6\u5939\u4f1a\u53d1\u73b0\u5f97\u5230\u4e86\u805a\u7c7b\u7684\u7ed3\u679c\uff1a<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9784615384615385\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_iaRtdFzJ7rd4PAjx2mrOyicXneBEdA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPRGDhbmMWxaY3C8PdKeNESftzKUiaRtdFzJ7rd4PAjx2mrOyicXneBEdA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"650\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p><strong>\u4e00\u81f4\u6027\u77e9\u9635<\/strong><\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.010886469673406\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_w5UMIKCa6JU6ibVP2ISYbFbujDst3g.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPErPcGmiblq9JyP7dksKpuDFQdBw5UMIKCa6JU6ibVP2ISYbFbujDst3g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"643\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p><strong>\u4e00\u81f4\u6027\u7d2f\u79ef\u5206\u5e03\u51fd\u6570\u56fe<\/strong><\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.0121765601217656\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_PEev5QfOp82DoBOBkbxtMZC3MaPDew.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPdrvTgkEuX8ZvicYxAF47HU0BUPEev5QfOp82DoBOBkbxtMZC3MaPDew\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"657\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p><strong>\u788e\u77f3\u56fe<\/strong><\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_Er8BvUv4PGbibviaqMhuvhqMjg8qow.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPCeWqAibEuMsWfcyNazrydeY1IRREr8BvUv4PGbibviaqMhuvhqMjg8qow\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"652\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u5728\u8fd9\u91cc\u5c0f\u82b1\u5c31\u4e0d\u5168\u90e8\u5c55\u793a\u4e86\uff0c\u5c0f\u4f19\u4f34\u4eec\u81ea\u5df1\u505a\u7684\u8bdd\u53ef\u4ee5\u6162\u6162\u770b\u3002<\/p>\n<p>\u4ece\u4e0a\u8ff0\u788e\u77f3\u56fe\u770b\u51fa\u5462\uff0c\u5728k=7,k=8\u5de6\u53f3\u65f6\u5019\u5462\uff0c\u6bd4\u8f83\u5e73\u7a33\uff0c\u524d\u9762K=3\uff0c\u548ck=4\u8fd9\u4e24\u4e2a\u5206\u7ec4\u6570\u95f4\u76f8\u5bf9\u5dee\u503c\u53d8\u5316\u8d8a\u5927\uff0c\u8bf4\u660e\u8be5\u5206\u7ec4\u8d8a\u6709\u4ef7\u503c\u3002\u5c0f\u4f19\u4f34\u9700\u8981\u5bf9\u75c7\u4e0b\u836f\uff0c\u67e5\u770b\u81ea\u5df1\u805a\u7c7b\u7684\u7ed3\u679c\u8fdb\u884c\u89e3\u91ca\u548c\u540e\u7eed\u7684\u5206\u6790\u3002<\/p>\n<p>\u56fe\u4e2dK\u503c\u5462\u5c31\u4ee3\u8868\u7c07\uff0c<\/p>\n<p>\u63a5\u4e0b\u6765\u6211\u4eec\u7ed8\u5236\u53e6\u4e00\u7ec4\u56fe\uff1a<\/p>\n<\/section>\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-width: 1px;border-radius: 8px;border-style: dotted;border-color: rgb(0, 0, 0);overflow: hidden;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"margin: 15px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(62, 62, 62);padding-right: 15px;padding-left: 15px;\">\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">\u805a\u7c7b\u4e00\u81f4\u6027(cluster-consensus)\u4ee5\u53ca\u6837\u54c1\u4e00\u81f4\u6027(item-consensus)<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">title=title,clusterAlg=”hc”,distance=”pearson”,seed=1,plot=”pdf”)<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">results[[2]][[“consensusMatrix”]][1:5,1:5]<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">results[[2]][[“consensusTree”]]<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">results[[2]][[“consensusClass”]][1:5]<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">icl = calcICL(results,title=title,plot=”pdf”) ##\u753b\u53e6\u4e00\u7ec4\u56fe\u7247<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u7ed3\u679c\u5982\u4e0b\uff1a<\/p>\n<p>\u805a\u7c7b\u4e00\u81f4\u6027(cluster-consensus)<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6444780635400907\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_Yygcp0dgwOgBicpOoicJWNMtAKRf8Q.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPdzr3RlhtWe7xY2vGdV2wHCvn94Yygcp0dgwOgBicpOoicJWNMtAKRf8Q\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"661\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p powered-by=\"xiumi.us\">\u6837\u54c1\u4e00\u81f4\u6027(item-consensus)<\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.2962406015037594\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_2cCSSymLt3d9yp3bySLc28ibUN2h6A.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPDY3GqNumzTg6tnOOXENssghGR2cCSSymLt3d9yp3bySLc28ibUN2h6A\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"665\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u5c0f\u4f19\u4f34\u4eec\u628a\u9700\u8981\u90a3\u4e9b\u56fe\u7247\u8fdb\u884c\u5c55\u793a\u5c31\u53ef\u4ee5\u4e86\u3002<\/p>\n<p>#\u4e0a\u8ff0\u5c31\u662f\u7ed8\u5236\u53e6\u4e00\u7ec4\u56fe\uff0c\u7136\u800c\u6211\u4eec\u8fd8\u9700\u8981\u505a\u7684\u662f\u628a\u7ed3\u679c\u4fdd\u5b58\u4e0b\u6765\u3002<\/p>\n<\/section>\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-width: 1px;border-radius: 8px;border-style: dotted;border-color: rgb(0, 0, 0);overflow: hidden;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"margin: 15px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(62, 62, 62);padding-right: 15px;padding-left: 15px;\">\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">group<-results[[2]][[“consensusClass”]]<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">group<-as.data.frame(group)<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">group$group <- factor(group$group,levels=c(1,2))<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">save(group,file = “group_AY.Rda”)#\u8fd9\u91cc\u628a\u5206\u7ec4\u7ed3\u679c\u4fdd\u5b58<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u7136\u800c\uff0c\u53c8\u4f1a\u6709\u5c0f\u4f19\u4f34\u4f1a\u95ee\u5982\u4f55\u5c55\u793a\u805a\u7c7b\u540e\u7684\u6548\u679c\u5462\u3002<\/p>\n<p>\u5c0f\u82b1\u5728\u8fd9\u91cc\u6559\u5927\u5bb6\u4e00\u79cd\u65b9\u5f0f\u7528\u70ed\u56fe\u7684\u65b9\u5f0f\u8fdb\u5c55\u5c55\u793a\uff0c<\/p>\n<p>\u7ed8\u5236ConsensusClusterPlus\u540e\u7684\u70ed\u56fe\uff1a<\/p>\n<p>\u8fd9\u4e2a\u65f6\u5019\u5c31\u7528\u5230\u4e0a\u8ff0\u54b1\u4eec\u4fdd\u5b58\u7684\u5206\u7ec4\u4fe1\u606f\u4e86\uff1a<\/p>\n<p>\u8ddf\u7740\u5c0f\u82b1\u7684\u4ee3\u7801\u5f80\u4e0b\u8dd1\u5c31\u53ef\u4ee5\u5566\uff01<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">library(pheatmap)<span class=\"code-snippet__comment\">#\u8c03\u7528\u4e00\u4e0b\u70ed\u56fe\u7684\u5305<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">group <- group %>%<\/span><\/code><code><span class=\"code-snippet_outer\">rownames_to_column(<span class=\"code-snippet__string\">\"sample\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">annotation <- group %>% arrange(group) %>% column_to_rownames(<span class=\"code-snippet__string\">\"sample\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">a <- group %>% arrange(group) %>% mutate(sample=substring(.$sample,<span class=\"code-snippet__number\">1<\/span>,<span class=\"code-snippet__number\">12<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">b <- t(exp_gene) %>%<\/span><\/code><code><span class=\"code-snippet_outer\">as.data.frame() %>%<\/span><\/code><code><span class=\"code-snippet_outer\">rownames_to_column(<span class=\"code-snippet__string\">\"sample\"<\/span>) %>%<\/span><\/code><code><span class=\"code-snippet_outer\">mutate(sample=substring(.$sample,<span class=\"code-snippet__number\">1<\/span>,<span class=\"code-snippet__number\">12<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">c <- inner_join(a,b,<span class=\"code-snippet__string\">\"sample\"<\/span>) %>% .[,-<span class=\"code-snippet__number\">2<\/span>] %>% column_to_rownames(<span class=\"code-snippet__string\">\"sample\"<\/span>) %>% t(.)<\/span><\/code><code><span class=\"code-snippet_outer\">pheatmap(<span class=\"code-snippet__built_in\">c<\/span>,annotation = annotation,<\/span><\/code><code><span class=\"code-snippet_outer\">cluster_cols = <span class=\"code-snippet__built_in\">F<\/span>,fontsize=<span class=\"code-snippet__number\">5<\/span>,fontsize_row=<span class=\"code-snippet__number\">5<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">scale=<span class=\"code-snippet__string\">\"row\"<\/span>,show_colnames=<span class=\"code-snippet__built_in\">F<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">fontsize_col=<span class=\"code-snippet__number\">3<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">bk <- <span class=\"code-snippet__built_in\">c<\/span>(seq(-<span class=\"code-snippet__number\">5<\/span>,-<span class=\"code-snippet__number\">0.1<\/span>,by=<span class=\"code-snippet__number\">0.01<\/span>),seq(<span class=\"code-snippet__number\">0<\/span>,<span class=\"code-snippet__number\">5<\/span>,by=<span class=\"code-snippet__number\">0.01<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">pheatmap(<span class=\"code-snippet__built_in\">c<\/span>,annotation = annotation,<\/span><\/code><code><span class=\"code-snippet_outer\">annotation_colors = <span class=\"code-snippet__built_in\">list<\/span>(group = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"1\"<\/span> =<span class=\"code-snippet__string\">\"#8B1C62\"<\/span>,<span class=\"code-snippet__string\">\"2\"<\/span>= <span class=\"code-snippet__string\">\"#EE9572\"<\/span>)),<\/span><\/code><code><span class=\"code-snippet_outer\">cluster_cols = <span class=\"code-snippet__built_in\">F<\/span>,fontsize=<span class=\"code-snippet__number\">10<\/span>,fontsize_row=<span class=\"code-snippet__number\">10<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">scale=<span class=\"code-snippet__string\">\"row\"<\/span>,show_colnames=<span class=\"code-snippet__built_in\">F<\/span>,cluster_row = <span class=\"code-snippet__built_in\">F<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">color = <span class=\"code-snippet__built_in\">c<\/span>(colorRampPalette(colors = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"#551A8B\"<\/span>,<span class=\"code-snippet__string\">\"white\"<\/span>))(<span class=\"code-snippet__built_in\">length<\/span>(bk)\/<span class=\"code-snippet__number\">2<\/span>),colorRampPalette(colors = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"white\"<\/span>,<span class=\"code-snippet__string\">\"#CD3700\"<\/span>))(<span class=\"code-snippet__built_in\">length<\/span>(bk)\/<span class=\"code-snippet__number\">2<\/span>)),<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#legend_breaks=seq(-3,3,1),<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">fontsize_col=<span class=\"code-snippet__number\">3<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">dev.off()<\/span><\/code><\/pre>\n<\/section>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u8fd9\u91cc\u70ed\u56fe\u7684\u53c2\u6570\u6bd4\u5982\uff1a\u989c\u8272\u7684\u7ed8\u5236\u90fd\u53ef\u4ee5\u6839\u636e\u5c0f\u4f19\u4f34\u81ea\u5df1\u7684\u9700\u6c42\u6765\u4fee\u6539\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5259259259259259\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_q1yIwGAF1MUEicOCBU9mUFald0gc2A.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZP0NRwcRrDGq78tTSr1cXXwsqS5q1yIwGAF1MUEicOCBU9mUFald0gc2A\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u6548\u679c\u5c31\u51fa\u6765\u4e86\uff0c\u53ef\u4ee5\u770b\u51fa\u6765\u5728MMP9\u548cCCND1\u7b49\u8fd9\u51e0\u4e2a\u57fa\u56e0\u805a\u7c7b\u6548\u679c\u6bd4\u8f83\u660e\u663e\uff0c\u5c0f\u82b1\u5728\u8fd9\u91cc\u5c55\u793a\u7684\u662fK=2\u60c5\u51b5\u4e0b\u805a\u7c7b\u7684\u70ed\u56fe\u3002\u5c0f\u4f19\u4f34\u4eec\u81ea\u5df1\u9009\u62e9K\u7684\u503c\u8fdb\u884c\u7ed8\u5236\u3002<\/p>\n<p>\u4e0b\u9762\u5c31\u53ef\u4ee5\u6839\u636e\u805a\u7c7b\u7684\u7ed3\u679c\u53bb\u540e\u7eed\u7684\u5206\u6790\u4e86\u3002\u6bd4\u5982;\u5206\u7ec4\u7684ssGSEA\u7b49\u7b49\u3002<\/p>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 98%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;height: auto;border-style: solid;border-width: 2px;border-color: rgb(160, 160, 160);padding: 27px;\">\n<section style=\"text-align: justify;line-height: 1.6;letter-spacing: 0px;padding-right: 6px;padding-left: 6px;\" powered-by=\"xiumi.us\">\n<p>\u5c0f\u4f19\u4f34\u4eec\u9700\u8981\u591a\u591a\u5b66\u4e60\u4ee3\u7801\u7684\u542b\u4e49\uff0c\u4ee5\u53ca\u5bf9\u56fe\u7247\u7684\u7406\u89e3\u624d\u80fd\uff0c\u66f4\u597d\u7684\u53bb\u8fd0\u7528\u3002<\/p>\n<p>\u4e0a\u8ff0\u5c31\u662f\u5bf9\u65e0\u76d1\u7763\u805a\u7c7b\u6cd5\u7684\u5b66\u4e60\u3002\u5c0f\u4f19\u4f34\u4eec\u662f\u5426\u5b66\u4f1a\u4e86\u5462<\/p>\n<p><br \/><\/p>\n<p>\u6b22\u8fce\u4f7f\u7528\uff1a\u4e91\u751f\u4fe1 – 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\/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzAwNjE0MDY3MQ==&mid=2650761303&idx=2&sn=6f73471d1e82c56c0b2160d0fcd32d53&scene=21#wechat_redirect\" textvalue=\"\" linktype=\"image\" imgurl=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/KDvR2NrGicSYCoxhZfqr5L0fxy3C9eSFdt72DV7zqsmrNaiaaoOhic3sHzUpBN4r4MaBCk9p9v16yZwvMvS5nM7sQ\/0?wx_fmt=jpeg\" imgdata=\"[object Object]\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.35083798882681566\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_pBN4r4MaBCk9p9v16yZwvMvS5nM7sQ-1.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/KDvR2NrGicSYCoxhZfqr5L0fxy3C9eSFdt72DV7zqsmrNaiaaoOhic3sHzUpBN4r4MaBCk9p9v16yZwvMvS5nM7sQ\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"895\" style=\"\" data-recalc-dims=\"1\" \/><\/span><\/a><br \/><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.3488888888888889\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_uKaqczIP6EMQhkT9sW7c1bKv6z9AAg-1.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/KDvR2NrGicSYCoxhZfqr5L0fxy3C9eSFdD9CpdQZl2iaySUTmNepgg2BpMuKaqczIP6EMQhkT9sW7c1bKv6z9AAg\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"900\" style=\"\" data-recalc-dims=\"1\" \/><\/p>\n<p powered-by=\"xiumi.us\">\uff08\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8df3\u8f6c\uff09<br \/><\/p>\n<section style=\"text-align: left;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section 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powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 50px;height: 40px;vertical-align: top;overflow: hidden;\">\n<section style=\"text-align: center;margin-right: 0%;margin-left: 0%;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7709090909090909\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_bS22fjgcooMQdszII7jt5cCSRvFoNA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPsvzeIO692C9QiaVoMOZY0VVjKbS22fjgcooMQdszII7jt5cCSRvFoNA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"275\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"display: none;margin-bottom: 24px;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<div class=\"msg_source_url\"><a href=\"http:\/\/www.biocloudservice.com\/home.html\" target=\"_blank\" rel=\"noopener\">\u9605\u8bfb\u539f\u6587<\/a><\/div>\n<p><\/content><\/p>\n<div class=\"msg_source_url\"><a href=\"http:\/\/www.biocloudservice.com\/home.html\" target=\"_blank\" rel=\"noopener\">\u9605\u8bfb\u539f\u6587<\/a><\/div>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8ddf\u7740\u5c0f\u82b1Get\u65e0\u76d1\u7763\u805a\u7c7b\uff01-ConsensusClusterPlus \u5c0f\u82b1 \u751f\u4fe1\u679c&nb […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/59428"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=59428"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/59428\/revisions"}],"predecessor-version":[{"id":59441,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/59428\/revisions\/59441"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=59428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=59428"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=59428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

{"id":59428,"date":"2024-06-17T08:03:41","date_gmt":"2024-06-17T00:03:41","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=59428"},"modified":"2024-06-17T08:03:41","modified_gmt":"2024-06-17T00:03:41","slug":"%e8%b7%9f%e7%9d%80%e5%b0%8f%e8%8a%b1get%e6%97%a0%e7%9b%91%e7%9d%a3%e8%81%9a%e7%b1%bb%ef%bc%81-consensusclusterplus","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=59428","title":{"rendered":"\u8ddf\u7740\u5c0f\u82b1Get\u65e0\u76d1\u7763\u805a\u7c7b\uff01-ConsensusClusterPlus"},"content":{"rendered":"

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powered-by=\"xiumi.us\">\n<p>\u5c0f\u4f19\u4f34\u5728\u505a\u751f\u4fe1\u5206\u6790\u7684\u65f6\u5019\uff0c\u4f1a\u7ecf\u5e38\u89c1\u5230\u805a\u7c7b\u8fd9\u4e2a\u540d\u8bcd\uff0c\u5374\u4e0d\u77e5\u9053\u662f\u4ec0\u4e48\u610f\u4e49\u3002\u5176\u5b9e\u5e73\u65f6\u6211\u4eec\u505a\u57fa\u56e0\u70ed\u56fe\u65f6\u5019\u5c31\u7528\u5230\u4e86\u805a\u7c7b\u7684\u601d\u60f3\u3002\u6709\u7684\u5c0f\u4f19\u4f34\u5728\u505a\u764c\u75c7\u5206\u6790\u65f6\u5019\uff0c\u4e5f\u89c1\u8fc7\u7ed9\u75be\u75c5\u505a\u5206\u5b50\u4e9a\u578b\uff0c\u8fd9\u4e2a\u65f6\u5019\u65e0\u76d1\u7763\u805a\u7c7b\u5c31\u6d3e\u4e0a\u7528\u573a\u4e86\u3002<\/p>\n<p>\u6240\u4ee5\u4eca\u5929\u5c0f\u82b1\u5e26\u5927\u5bb6\u4e86\u89e3\u65e0\u76d1\u7763\u805a\u7c7b\uff0c\u5e76\u5b66\u4e60\u5982\u4f55\u4f7f\u7528\u5b83\u3002<\/p>\n<p>\u9996\u5148\u6211\u4eec\u5148\u5927\u81f4\u4e86\u89e3\u4e00\u4e0b\u4ec0\u4e48\u662f\u65e0\u76d1\u7763\u805a\u7c7b\u3002\u5c31\u597d\u6bd4\u4e00\u81f4\u6027\u805a\u7c7b\u65b9\u6cd5\u5305\u62ec\u4ece\u4e00\u7ec4\u9879\u76ee\u4e2d\u8fdb\u884c\u6b21\u62bd\u6837\uff0c\u4f8b\u5982\u5fae\u9635\u5217\uff0c\u5e76\u786e\u5b9a\u7279\u5b9a\u7c07\u8ba1\u6570\uff08k\uff09\u7684\u7c07\u3002\u7136\u540e\uff0c\u5bf9\u5171\u8bc6\u503c\uff0c\u4e24\u4e2a\u9879\u76ee\u5360\u5728\u540c\u4e00\u5b50\u6837\u672c\u4e2d\u53d1\u751f\u7684\u6b21\u6570\u4e2d\u6709\u76f8\u540c\u7684\u805a\u7c7b\uff0c\u8ba1\u7b97\u5e76\u5b58\u50a8\u5728\u6bcf\u4e2ak\u7684\u5bf9\u79f0\u4e00\u81f4\u77e9\u9635\u4e2d\u3002<\/p>\n<p>\u5177\u4f53\u7684\u542b\u4e49\u6211\u4eec\u4e0d\u5728\u6b64\u4e00\u4e00\u8d58\u8ff0\u3002<\/p>\n<p>\u5c0f\u82b1\u5728\u8fd9\u91cc\u7528\u5230\u7684\u662fConsensusClusterPlus\u8fd9\u4e2a\u5305\u5bf9\u57fa\u56e0\u8fdb\u884c\u805a\u7c7b\u3002<\/p>\n<p>\u6240\u9700\u8981\u7684\u662f\u4e0b\u9762\u8fd9\u79cd\u683c\u5f0f\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\uff1a<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.37130801687763715\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/1_c2Cqd0kJeKHDAic3qjBic0Lj2rzIJg.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPHEhGT1F6DI6EgqcycfCWFBHGZQc2Cqd0kJeKHDAic3qjBic0Lj2rzIJg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"948\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#install.packages(\"BiocManager\")<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#BiocManager::install('ConsensusClusterPlus')#\u5c0f\u4f19\u4f34\u6ca1\u6709\u7684\u81ea\u5df1\u8981\u4e0b\u8f7d\u4e00\u4e0b<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">library(tidyverse)<\/span><\/code><code><span class=\"code-snippet_outer\">library(ConsensusClusterPlus)<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u5bfc\u5165\u6570\u636e<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">exp <- read.table(<span class=\"code-snippet__string\">\"text1.txt\"<\/span>,sep = <span class=\"code-snippet__string\">\"t\"<\/span>,row.names = <span class=\"code-snippet__number\">1<\/span>,check.names = <span class=\"code-snippet__built_in\">F<\/span>,stringsAsFactors = <span class=\"code-snippet__built_in\">F<\/span>,header = <span class=\"code-snippet__built_in\">T<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">d=as.matrix(<span class=\"code-snippet__built_in\">exp<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">gene <- <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"MMP9\"<\/span>,<span class=\"code-snippet__string\">\"CCND1\"<\/span>,<span class=\"code-snippet__string\">\"STAT1\"<\/span>,<span class=\"code-snippet__string\">\"AR\"<\/span>,<span class=\"code-snippet__string\">\"AKR1C3\"<\/span>,<span class=\"code-snippet__string\">\"GSTP1\"<\/span>,<span class=\"code-snippet__string\">\"PGR\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">d <- d[gene,]<\/span><\/code><code><span class=\"code-snippet_outer\">mads=apply(d,<span class=\"code-snippet__number\">1<\/span>,mad)<\/span><\/code><code><span class=\"code-snippet_outer\">d=d[rev(order(mads))[<span class=\"code-snippet__number\">1<\/span>:<span class=\"code-snippet__number\">7<\/span>],] <span class=\"code-snippet__comment\">#7\u662f\u57fa\u56e0\u4e2a\u6570<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">d = sweep(d,<span class=\"code-snippet__number\">1<\/span>, apply(d,<span class=\"code-snippet__number\">1<\/span>,median,na.rm=<span class=\"code-snippet__built_in\">T<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">title=(<span class=\"code-snippet__string\">\"JULEI\"<\/span>) <span class=\"code-snippet__comment\">##\u6587\u4ef6\u5939\u8f93\u51fa\u56fe\u7247\u7684\u4f4d\u7f6e<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">set.seed(<span class=\"code-snippet__number\">1<\/span>) <span class=\"code-snippet__comment\">#\u6211\u53d1\u73b0\u8bbe\u4e0d\u8bbe\u7f6e\u79cd\u5b50\u90fd\u4e00\u6837<\/span><\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#\u8fd9\u91cc\u5c0f\u82b1\u9009\u53d6\u81ea\u5df1\u7684\u793a\u4f8b\u6570\u636e\uff0c\u5c0f\u4f19\u4f34\u4eec\u6574\u7406\u81ea\u5df1\u60f3\u53bb\u805a\u7c7b\u7684\u57fa\u56e0\u3002<\/span><\/span><\/code><\/pre>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u7136\u540e\u6211\u4eec\u6253\u5f00JULEI\u8fd9\u4e2a\u6587\u4ef6\u5939\u4f1a\u53d1\u73b0\u5f97\u5230\u4e86\u805a\u7c7b\u7684\u7ed3\u679c\uff1a<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9784615384615385\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_iaRtdFzJ7rd4PAjx2mrOyicXneBEdA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPRGDhbmMWxaY3C8PdKeNESftzKUiaRtdFzJ7rd4PAjx2mrOyicXneBEdA\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"650\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p><strong>\u4e00\u81f4\u6027\u77e9\u9635<\/strong><\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.010886469673406\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_w5UMIKCa6JU6ibVP2ISYbFbujDst3g.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPErPcGmiblq9JyP7dksKpuDFQdBw5UMIKCa6JU6ibVP2ISYbFbujDst3g\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"643\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p><strong>\u4e00\u81f4\u6027\u7d2f\u79ef\u5206\u5e03\u51fd\u6570\u56fe<\/strong><\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.0121765601217656\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_PEev5QfOp82DoBOBkbxtMZC3MaPDew.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPdrvTgkEuX8ZvicYxAF47HU0BUPEev5QfOp82DoBOBkbxtMZC3MaPDew\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"657\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p><strong>\u788e\u77f3\u56fe<\/strong><\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_Er8BvUv4PGbibviaqMhuvhqMjg8qow.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPCeWqAibEuMsWfcyNazrydeY1IRREr8BvUv4PGbibviaqMhuvhqMjg8qow\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"652\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u5728\u8fd9\u91cc\u5c0f\u82b1\u5c31\u4e0d\u5168\u90e8\u5c55\u793a\u4e86\uff0c\u5c0f\u4f19\u4f34\u4eec\u81ea\u5df1\u505a\u7684\u8bdd\u53ef\u4ee5\u6162\u6162\u770b\u3002<\/p>\n<p>\u4ece\u4e0a\u8ff0\u788e\u77f3\u56fe\u770b\u51fa\u5462\uff0c\u5728k=7,k=8\u5de6\u53f3\u65f6\u5019\u5462\uff0c\u6bd4\u8f83\u5e73\u7a33\uff0c\u524d\u9762K=3\uff0c\u548ck=4\u8fd9\u4e24\u4e2a\u5206\u7ec4\u6570\u95f4\u76f8\u5bf9\u5dee\u503c\u53d8\u5316\u8d8a\u5927\uff0c\u8bf4\u660e\u8be5\u5206\u7ec4\u8d8a\u6709\u4ef7\u503c\u3002\u5c0f\u4f19\u4f34\u9700\u8981\u5bf9\u75c7\u4e0b\u836f\uff0c\u67e5\u770b\u81ea\u5df1\u805a\u7c7b\u7684\u7ed3\u679c\u8fdb\u884c\u89e3\u91ca\u548c\u540e\u7eed\u7684\u5206\u6790\u3002<\/p>\n<p>\u56fe\u4e2dK\u503c\u5462\u5c31\u4ee3\u8868\u7c07\uff0c<\/p>\n<p>\u63a5\u4e0b\u6765\u6211\u4eec\u7ed8\u5236\u53e6\u4e00\u7ec4\u56fe\uff1a<\/p>\n<\/section>\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-width: 1px;border-radius: 8px;border-style: dotted;border-color: rgb(0, 0, 0);overflow: hidden;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"margin: 15px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(62, 62, 62);padding-right: 15px;padding-left: 15px;\">\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">\u805a\u7c7b\u4e00\u81f4\u6027(cluster-consensus)\u4ee5\u53ca\u6837\u54c1\u4e00\u81f4\u6027(item-consensus)<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">title=title,clusterAlg=”hc”,distance=”pearson”,seed=1,plot=”pdf”)<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">results[[2]][[“consensusMatrix”]][1:5,1:5]<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">results[[2]][[“consensusTree”]]<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">results[[2]][[“consensusClass”]][1:5]<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">icl = calcICL(results,title=title,plot=”pdf”) ##\u753b\u53e6\u4e00\u7ec4\u56fe\u7247<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u7ed3\u679c\u5982\u4e0b\uff1a<\/p>\n<p>\u805a\u7c7b\u4e00\u81f4\u6027(cluster-consensus)<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.6444780635400907\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_Yygcp0dgwOgBicpOoicJWNMtAKRf8Q.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPdzr3RlhtWe7xY2vGdV2wHCvn94Yygcp0dgwOgBicpOoicJWNMtAKRf8Q\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"661\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<p powered-by=\"xiumi.us\">\u6837\u54c1\u4e00\u81f4\u6027(item-consensus)<\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.2962406015037594\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_2cCSSymLt3d9yp3bySLc28ibUN2h6A.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZPDY3GqNumzTg6tnOOXENssghGR2cCSSymLt3d9yp3bySLc28ibUN2h6A\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"665\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u5c0f\u4f19\u4f34\u4eec\u628a\u9700\u8981\u90a3\u4e9b\u56fe\u7247\u8fdb\u884c\u5c55\u793a\u5c31\u53ef\u4ee5\u4e86\u3002<\/p>\n<p>#\u4e0a\u8ff0\u5c31\u662f\u7ed8\u5236\u53e6\u4e00\u7ec4\u56fe\uff0c\u7136\u800c\u6211\u4eec\u8fd8\u9700\u8981\u505a\u7684\u662f\u628a\u7ed3\u679c\u4fdd\u5b58\u4e0b\u6765\u3002<\/p>\n<\/section>\n<section style=\"justify-content: flex-start;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-width: 1px;border-radius: 8px;border-style: dotted;border-color: rgb(0, 0, 0);overflow: hidden;align-self: flex-start;flex: 0 0 auto;\">\n<section style=\"margin: 15px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(62, 62, 62);padding-right: 15px;padding-left: 15px;\">\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">group<-results[[2]][[“consensusClass”]]<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">group<-as.data.frame(group)<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">group$group <- factor(group$group,levels=c(1,2))<\/span><\/p>\n<p><span style=\"text-shadow: rgb(255, 253, 231) 0.766044px 0.642788px 2px;\">save(group,file = “group_AY.Rda”)#\u8fd9\u91cc\u628a\u5206\u7ec4\u7ed3\u679c\u4fdd\u5b58<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u7136\u800c\uff0c\u53c8\u4f1a\u6709\u5c0f\u4f19\u4f34\u4f1a\u95ee\u5982\u4f55\u5c55\u793a\u805a\u7c7b\u540e\u7684\u6548\u679c\u5462\u3002<\/p>\n<p>\u5c0f\u82b1\u5728\u8fd9\u91cc\u6559\u5927\u5bb6\u4e00\u79cd\u65b9\u5f0f\u7528\u70ed\u56fe\u7684\u65b9\u5f0f\u8fdb\u5c55\u5c55\u793a\uff0c<\/p>\n<p>\u7ed8\u5236ConsensusClusterPlus\u540e\u7684\u70ed\u56fe\uff1a<\/p>\n<p>\u8fd9\u4e2a\u65f6\u5019\u5c31\u7528\u5230\u4e0a\u8ff0\u54b1\u4eec\u4fdd\u5b58\u7684\u5206\u7ec4\u4fe1\u606f\u4e86\uff1a<\/p>\n<p>\u8ddf\u7740\u5c0f\u82b1\u7684\u4ee3\u7801\u5f80\u4e0b\u8dd1\u5c31\u53ef\u4ee5\u5566\uff01<\/p>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"r\"><code><span class=\"code-snippet_outer\">library(pheatmap)<span class=\"code-snippet__comment\">#\u8c03\u7528\u4e00\u4e0b\u70ed\u56fe\u7684\u5305<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">group <- group %>%<\/span><\/code><code><span class=\"code-snippet_outer\">rownames_to_column(<span class=\"code-snippet__string\">\"sample\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">annotation <- group %>% arrange(group) %>% column_to_rownames(<span class=\"code-snippet__string\">\"sample\"<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">a <- group %>% arrange(group) %>% mutate(sample=substring(.$sample,<span class=\"code-snippet__number\">1<\/span>,<span class=\"code-snippet__number\">12<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">b <- t(exp_gene) %>%<\/span><\/code><code><span class=\"code-snippet_outer\">as.data.frame() %>%<\/span><\/code><code><span class=\"code-snippet_outer\">rownames_to_column(<span class=\"code-snippet__string\">\"sample\"<\/span>) %>%<\/span><\/code><code><span class=\"code-snippet_outer\">mutate(sample=substring(.$sample,<span class=\"code-snippet__number\">1<\/span>,<span class=\"code-snippet__number\">12<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">c <- inner_join(a,b,<span class=\"code-snippet__string\">\"sample\"<\/span>) %>% .[,-<span class=\"code-snippet__number\">2<\/span>] %>% column_to_rownames(<span class=\"code-snippet__string\">\"sample\"<\/span>) %>% t(.)<\/span><\/code><code><span class=\"code-snippet_outer\">pheatmap(<span class=\"code-snippet__built_in\">c<\/span>,annotation = annotation,<\/span><\/code><code><span class=\"code-snippet_outer\">cluster_cols = <span class=\"code-snippet__built_in\">F<\/span>,fontsize=<span class=\"code-snippet__number\">5<\/span>,fontsize_row=<span class=\"code-snippet__number\">5<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">scale=<span class=\"code-snippet__string\">\"row\"<\/span>,show_colnames=<span class=\"code-snippet__built_in\">F<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">fontsize_col=<span class=\"code-snippet__number\">3<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">bk <- <span class=\"code-snippet__built_in\">c<\/span>(seq(-<span class=\"code-snippet__number\">5<\/span>,-<span class=\"code-snippet__number\">0.1<\/span>,by=<span class=\"code-snippet__number\">0.01<\/span>),seq(<span class=\"code-snippet__number\">0<\/span>,<span class=\"code-snippet__number\">5<\/span>,by=<span class=\"code-snippet__number\">0.01<\/span>))<\/span><\/code><code><span class=\"code-snippet_outer\">pheatmap(<span class=\"code-snippet__built_in\">c<\/span>,annotation = annotation,<\/span><\/code><code><span class=\"code-snippet_outer\">annotation_colors = <span class=\"code-snippet__built_in\">list<\/span>(group = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"1\"<\/span> =<span class=\"code-snippet__string\">\"#8B1C62\"<\/span>,<span class=\"code-snippet__string\">\"2\"<\/span>= <span class=\"code-snippet__string\">\"#EE9572\"<\/span>)),<\/span><\/code><code><span class=\"code-snippet_outer\">cluster_cols = <span class=\"code-snippet__built_in\">F<\/span>,fontsize=<span class=\"code-snippet__number\">10<\/span>,fontsize_row=<span class=\"code-snippet__number\">10<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">scale=<span class=\"code-snippet__string\">\"row\"<\/span>,show_colnames=<span class=\"code-snippet__built_in\">F<\/span>,cluster_row = <span class=\"code-snippet__built_in\">F<\/span>,<\/span><\/code><code><span class=\"code-snippet_outer\">color = <span class=\"code-snippet__built_in\">c<\/span>(colorRampPalette(colors = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"#551A8B\"<\/span>,<span class=\"code-snippet__string\">\"white\"<\/span>))(<span class=\"code-snippet__built_in\">length<\/span>(bk)\/<span class=\"code-snippet__number\">2<\/span>),colorRampPalette(colors = <span class=\"code-snippet__built_in\">c<\/span>(<span class=\"code-snippet__string\">\"white\"<\/span>,<span class=\"code-snippet__string\">\"#CD3700\"<\/span>))(<span class=\"code-snippet__built_in\">length<\/span>(bk)\/<span class=\"code-snippet__number\">2<\/span>)),<\/span><\/code><code><span class=\"code-snippet_outer\"><span class=\"code-snippet__comment\">#legend_breaks=seq(-3,3,1),<\/span><\/span><\/code><code><span class=\"code-snippet_outer\">fontsize_col=<span class=\"code-snippet__number\">3<\/span>)<\/span><\/code><code><span class=\"code-snippet_outer\">dev.off()<\/span><\/code><\/pre>\n<\/section>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u8fd9\u91cc\u70ed\u56fe\u7684\u53c2\u6570\u6bd4\u5982\uff1a\u989c\u8272\u7684\u7ed8\u5236\u90fd\u53ef\u4ee5\u6839\u636e\u5c0f\u4f19\u4f34\u81ea\u5df1\u7684\u9700\u6c42\u6765\u4fee\u6539\u3002<\/p>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5259259259259259\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_q1yIwGAF1MUEicOCBU9mUFald0gc2A.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/KDvR2NrGicSYBCJ7sE3jUBW7JTbSD1ibZP0NRwcRrDGq78tTSr1cXXwsqS5q1yIwGAF1MUEicOCBU9mUFald0gc2A\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"padding-right: 12px;padding-left: 12px;\" powered-by=\"xiumi.us\">\n<p>\u6548\u679c\u5c31\u51fa\u6765\u4e86\uff0c\u53ef\u4ee5\u770b\u51fa\u6765\u5728MMP9\u548cCCND1\u7b49\u8fd9\u51e0\u4e2a\u57fa\u56e0\u805a\u7c7b\u6548\u679c\u6bd4\u8f83\u660e\u663e\uff0c\u5c0f\u82b1\u5728\u8fd9\u91cc\u5c55\u793a\u7684\u662fK=2\u60c5\u51b5\u4e0b\u805a\u7c7b\u7684\u70ed\u56fe\u3002\u5c0f\u4f19\u4f34\u4eec\u81ea\u5df1\u9009\u62e9K\u7684\u503c\u8fdb\u884c\u7ed8\u5236\u3002<\/p>\n<p>\u4e0b\u9762\u5c31\u53ef\u4ee5\u6839\u636e\u805a\u7c7b\u7684\u7ed3\u679c\u53bb\u540e\u7eed\u7684\u5206\u6790\u4e86\u3002\u6bd4\u5982;\u5206\u7ec4\u7684ssGSEA\u7b49\u7b49\u3002<\/p>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 98%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;height: auto;border-style: solid;border-width: 2px;border-color: rgb(160, 160, 160);padding: 27px;\">\n<section style=\"text-align: justify;line-height: 1.6;letter-spacing: 0px;padding-right: 6px;padding-left: 6px;\" powered-by=\"xiumi.us\">\n<p>\u5c0f\u4f19\u4f34\u4eec\u9700\u8981\u591a\u591a\u5b66\u4e60\u4ee3\u7801\u7684\u542b\u4e49\uff0c\u4ee5\u53ca\u5bf9\u56fe\u7247\u7684\u7406\u89e3\u624d\u80fd\uff0c\u66f4\u597d\u7684\u53bb\u8fd0\u7528\u3002<\/p>\n<p>\u4e0a\u8ff0\u5c31\u662f\u5bf9\u65e0\u76d1\u7763\u805a\u7c7b\u6cd5\u7684\u5b66\u4e60\u3002\u5c0f\u4f19\u4f34\u4eec\u662f\u5426\u5b66\u4f1a\u4e86\u5462<\/p>\n<p><br \/><\/p>\n<p>\u6b22\u8fce\u4f7f\u7528\uff1a\u4e91\u751f\u4fe1 – \u5b66\u751f\u7269\u4fe1\u606f\u5b66 (biocloudservice.com)<\/p>\n<p><br \/><\/p>\n<p>\u5982\u679c\u60f3\u7528\u670d\u52a1\u5668\u53ef\u4ee5\u8054\u7cfb\u5fae\u4fe1\uff1a18502195490\uff08\u5feb\u6765\u8054\u7cfb\u6211\u4eec\u4f7f\u7528\u5427\uff01\uff09<\/p>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;display: flex;flex-flow: row;transform: translate3d(40px, 0px, 0px);margin-bottom: -40px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;min-width: 5%;height: auto;\">\n<section style=\"transform: rotateZ(45deg);\" powered-by=\"xiumi.us\">\n<section style=\"text-align: center;\">\n<section style=\"display: inline-block;width: 26px;height: 26px;vertical-align: top;overflow: hidden;background-color: rgb(255, 255, 255);border-left: 1px solid rgb(160, 160, 160);border-bottom-left-radius: 0px;\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p><br 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