{"id":59903,"date":"2024-06-17T10:34:08","date_gmt":"2024-06-17T02:34:08","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=59903"},"modified":"2024-06-17T10:34:08","modified_gmt":"2024-06-17T02:34:08","slug":"%e5%8d%95%e7%bb%86%e8%83%9e%e6%95%b0%e6%8d%ae%e6%8c%96%e6%8e%98%e4%b9%9f%e5%8d%b7%e4%b8%8a%e5%a4%a9%e4%ba%86%ef%bc%9f11%e5%88%86%e7%ba%af%e5%88%86%e6%9e%90%e6%9c%80%e6%96%b0%e6%8a%a5%e9%81%93","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=59903","title":{"rendered":"\u5355\u7ec6\u80de\u6570\u636e\u6316\u6398\u4e5f\u5377\u4e0a\u5929\u4e86\uff1f11\u5206+\u7eaf\u5206\u6790\u6700\u65b0\u62a5\u9053\uff1a\u8fd9\u4e2aR\u5305\u89e3\u9501\u5355\u7ec6\u80de\u6316\u6398\u65b0\u59ff\u52bf\u5566\uff01"},"content":{"rendered":"


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16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010201\" data-ratio=\"0.8443271767810027\" data-type=\"png\" data-w=\"379\" height=\"155 .1400146484375\" width=\"183 .74002075195312\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_2vV3dvq1ia2dNGm9HSwWuibcicJHQg.png?resize=183%2C155\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LTOPdIbQTQff3FRP1fvanVIh4QNdIcMx80DBTM8j5ibbFKmrbqx2vV3dvq1ia2dNGm9HSwWuibcicJHQg\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u597d\u7684\u5206\u6790\u5de5\u5177\u80fd\u4e3a\u6211\u4eec\u7684\u6587\u7ae0\u6dfb\u5f69\u4e0d\u5c11\u3002\u5c0f\u9014\u4eca\u5929\u5e26\u6765\u4e00\u4efd\u5927\u793c<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">SCORPION\uff0c\u8fd9\u4e2a\u5de5\u5177\u53ef\u4ee5\u66f4\u597d\u5730\u5904\u7406\u6211\u4eec\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6570\u636e\uff0c\u65e0\u8bba\u662f\u81ea\u6d4b\u6570\u636e\u8fd8\u662f\u6316\u6398\u7684\u516c\u5171\u6570\u636e\uff0c\u7814\u7a76\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u751a\u81f3\u662f\u4fe1\u53f7\u901a\u8def\u7b80\u76f4\u201c\u4e00\u952e\u83b7\u53d6\u201d\uff0c\u5de5\u5177\u4e5f\u5f00\u53d1\u4e3aR\u5305\u4f9b\u5927\u5bb6\u4f7f\u7528\u5566\uff01<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">\uff08https:\/\/CRAN.R-project.org\/package=SCORPION\uff09<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u3002\u5b66\u4f1a\u4f7f\u7528\u65b0R\u5305\u5c31\u80fd\u8ba9\u6587\u7ae0\u66f4\u4e0a\u4e00\u5c42\u697c\u5566\uff0c\u5feb\u6765\u5feb\u6765\uff1a<\/span><\/span><\/section>\n<section style=\"font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: windowtext;font-weight: normal;\">1.<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5f00\u53d1<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">SCORPION\u7b97\u6cd5\uff0c\u5e76\u8bc1\u660e\u76f8\u5bf9PIDC\u3001PPCOR\u7b4912\u79cd\u7c7b\u4f3c\u7b97\u6cd5\u7684\u4f18\u8d8a\u6027<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u3002<\/span><\/span><\/section>\n<section style=\"font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: windowtext;font-weight: normal;\">2.<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5e94\u7528\u4e24\u9879\u6570\u636e\u96c6<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">\u8bc4\u4f30SCORPION\u5bf9\u8f6c\u5f55\u56e0\u5b50\u8c03\u63a7\u7f51\u7edc\u53d1\u751f\u53d8\u5316\u7684\u68c0\u6d4b\u80fd\u529b<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u3002<\/span><\/span><\/section>\n<section style=\"font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: windowtext;font-weight: normal;\">3.<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5bf9\u516c\u5f00\u7684scRNA-seq\u6570\u636e\u5e94\u7528SCORPION\u5de5\u5177\uff0c<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">\u6784\u5efa\u8f6c\u5f55\u7ec4\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff0c\u8bc1\u660e\u5bf9\u7ec6\u80de\u5206\u578b\u548c\u75be\u75c5\u5206\u7c7b\u7684\u5b9e\u7528\u6027<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-left: 18pt;text-indent: -18pt;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: windowtext;font-weight: normal;\">4.<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6839\u636e\u7ed3\u76f4\u80a0\u764cCRC\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u6570\u636e\uff0c\u4f7f\u7528<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">SCORPION\u5206\u6790\u4e0d\u540c\u7a0b\u5ea6\u7684\u75c5\u53d8\u7ec4\u7ec7\u7ec6\u80de\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u53d8\u5316\uff0c\u8868\u5f81\u5f71\u54cd\u60a3\u8005\u751f\u5b58\u7684\u80bf\u7624\u5185\u7279\u5f81<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\uff0c\u8bc6\u522b\u65b0\u7684\u751f\u7269\u6807\u5fd7\u7269\u548c\u9776\u6807\u3002<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u73b0\u6210\u7684\u5de5\u5177\u5949\u4e0a\uff0c\u5c0f\u9014\u8bb2\u5b8c\u5927\u5bb6\u53ef\u8981\u597d\u597d\u8bd5\u8bd5\u5462\uff01<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(255, 0, 0);font-weight: bold;\" background:=\"background:\" mso-highlight:=\"mso-highlight:\">\u60f3\u7528\u7c7b\u4f3c\u7684\u751f\u4fe1\u5de5\u5177\u4e3a\u81ea\u5df1\u7684\u6587\u7ae0\u9526\u4e0a\u6dfb\u82b1\uff1f\u53c8\u600e\u6837\u548c\u70ed\u70b9\u8bdd\u9898\u6574\u5408\u5206\u6790\uff1f\u6216\u662f\u62c5\u5fc3\u9009\u9898\u62c9\u8de8\uff1f\u5c0f\u9014\u7684\u670d\u52a1\u5927\u793c\u5305\u4e00\u5b9a\u80fd\u4e3a\u4f60\u7684SCI\u4e4b\u8def\u62ab\u8346\u65a9\u68d8\uff01<\/span><span style=\"font-size: 16px;line-height: 200%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\" background:=\"background:\" mso-highlight:=\"mso-highlight:\">~<\/span><\/span><\/section>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-imgfileid=\"100006476\" data-ratio=\"1\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"430\" style=\"width: 182px;height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_f6PG40Qrdu5e9B1iaIMItPiajABYWA-11.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxqaqPbQprPd4vw8Ytp0cprbzXiakMDdFriaB6B59ibhlBCrNyQFf6PG40Qrdu5e9B1iaIMItPiajABYWA\/640?wx_fmt=jpeg'\" data-recalc-dims=\"1\" \/><\/p>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 200%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\" background:=\"background:\" mso-highlight:=\"mso-highlight:\"><\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010198\" data-ratio=\"0.4283746556473829\" data-type=\"png\" data-w=\"726\" height=\"237 .0\" width=\"553 .2100219726562\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_ME49syQ55xjMqQlXgAlw833pMUeH6Q.png?resize=553%2C237\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LTOPdIbQTQff3FRP1fvanVI3lRFZRN2lic0zVSZBt7Ixr8h3ME49syQ55xjMqQlXgAlw833pMUeH6Q\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: -21pt;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u9898\u76ee\uff1a\u57fa\u4e8e\u9ad8\u901a\u91cf\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5b66\u6570\u636e\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u7684\u7fa4\u4f53\u6c34\u5e73\u6bd4\u8f83<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: -21pt;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);font-style: italic;\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6742\u5fd7\uff1anature computational science<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: -21pt;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">11.3<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: -21pt;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Wingdings;font-variant: normal;text-transform: none;color: rgb(237, 125, 49);\">l<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u53d1\u8868\u65f6\u95f4\uff1a2024\u5e74<\/span><span style=\"font-size: 16px;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">3<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6708<\/span><\/span><\/section>\n<section style=\"text-align: justify;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-left: 21pt;text-indent: -21pt;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\"><span style=\"outline: 0px;font-size: 16px;letter-spacing: 0.544px;font-family: system-ui, -apple-system, "system-ui", "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);color: rgb(0, 82, 255);\"><span style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><\/strong><\/span><\/span><\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u7814\u7a76\u80cc\u666f<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u771f\u6838\u751f\u7269\u4e2d\u57fa\u56e0\u8868\u8fbe\u53d7\u5230\u8f6c\u5f55\u56e0\u5b50\u7684\u4e25\u683c\u8c03\u63a7\uff0c\u8c03\u63a7\u76f8\u4e92\u4f5c\u7528\u7684\u6539\u53d8\u53ef\u80fd\u5bfc\u81f4\u5f02\u5e38\u8868\u8fbe\u8c31\u548c\u75c5\u53d8\u8868\u578b\u3002\u8f6c\u5f55\u7ec4\u5b66\u6570\u636e\u53ef\u4ee5\u901a\u8fc7\u68c0\u67e5\u57fa\u56e0\u7684\u5171\u8868\u8fbe\u6a21\u5f0f\u6765\u63a8\u65ad\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff0c\u8fd9\u4e9b\u57fa\u56e0\u662f\u76f8\u540c\u8c03\u63a7\u7a0b\u5e8f\u7684\u4e00\u90e8\u5206\u3002\u5229\u7528<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">sc\u6216snRNA-seq\u6570\u636e\u4e2d\u7684\u57fa\u56e0\u8868\u8fbe\u53d8\u5f02\u6027\uff0c\u5728\u5355\u4e2a\u6837\u672c\u4e2d\u63a8\u65ad\u51fa\u6bcf\u79cd\u7ec6\u80de\u7c7b\u578b\u6216\u7ec6\u80de\u72b6\u6001\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u662f\u53ef\u80fd\u7684\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4e3a\u4e86\u786e\u5b9a\u5bfc\u81f4\u7fa4\u4f53\u5185\u6837\u672c\u95f4\u8868\u578b\u53d8\u5316\u7684\u4e00\u81f4\u673a\u5236\u6a21\u5f0f\uff0c\u8f6c\u5f55\u56e0\u5b50\u53ca\u5176\u9776\u57fa\u56e0\u76f8\u4e92\u4f5c\u7528\u4e4b\u95f4\u7684\u751f\u7269\u5b66\u53d8\u5f02\u6027\u5e94\u8be5\u7406\u60f3\u5730\u8de8\u591a\u4e2a\u6837\u672c\u8fdb\u884c\u5efa\u6a21\u3002\u4f7f\u7528<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">sc\u6216snRNA-seq<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u7684\u9ad8\u901a\u91cf\u6570\u636e\u6765\u521b\u5efa\u53ef\u6bd4\u8f83\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u662f\u4e00\u9879\u8270\u5de8\u7684\u4efb\u52a1\uff0c\u8fd9\u7c7b\u6570\u636e\u9ad8\u5ea6\u7a00\u758f\uff0c\u5e76\u4e14\u6587\u5e93\u51c6\u5907\u8fc7\u7a0b\u4e2d\u7684\u975e\u751f\u7269\u5b66\u56e0\u7d20\u7ecf\u5e38\u5f71\u54cd\u6570\u636e\uff0c\u9700\u8981\u5f00\u53d1\u9ad8\u6548\u7684\u6280\u672f\u3002<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6570\u636e\u6765\u6e90<\/span><\/section>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\" style=\"margin-left: 0px;border-width: initial;border-style: none;border-color: initial;border-collapse: collapse;width: 100%;\">\n<tbody>\n<tr>\n<td width=\"94\" valign=\"top\" style=\"width:70.75pt;background:#9CC4E6;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: bold;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">\u6570\u636e\u96c6<\/span><\/section>\n<\/td>\n<td width=\"90\" valign=\"top\" style=\"width:67.8pt;background:#9CC4E6;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: bold;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">\u6570\u636e\u5e93<\/span><\/section>\n<\/td>\n<td width=\"79\" valign=\"top\" style=\"width:59.05pt;background:#9CC4E6;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: bold;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">\u6570\u636e\u7c7b\u578b<\/span><\/section>\n<\/td>\n<td width=\"305\" valign=\"top\" style=\"width:228.5pt;background:#9CC4E6;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: bold;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">\u8be6\u7ec6\u5185\u5bb9<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"94\" valign=\"top\" style=\"width:70.75pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">GSE132465<\/span><\/section>\n<\/td>\n<td width=\"90\" valign=\"top\" style=\"width:67.8pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;letter-spacing: 1px;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"79\" valign=\"top\" style=\"width:59.05pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;letter-spacing: 1px;\">scRNA-seq<\/span><\/section>\n<\/td>\n<td width=\"305\" valign=\"top\" style=\"width:228.5pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">23\u4f8b\u539f\u53d1\u6027CRC\u60a3\u8005\u548c10\u4efd\u5339\u914d\u7684\u6b63\u5e38\u7c98\u819c\u6837\u672c\u768463,689\u4e2a\u7ec6\u80de\u7684\u5355\u7ec6\u80de 3′ RNA \u6d4b\u5e8f\u6570\u636e<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"94\" valign=\"top\" style=\"width:70.75pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">GSE144735<\/span><\/section>\n<\/td>\n<td width=\"90\" valign=\"top\" style=\"width:67.8pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;letter-spacing: 1px;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"79\" valign=\"top\" style=\"width:59.05pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;letter-spacing: 1px;\">scRNA-seq<\/span><\/section>\n<\/td>\n<td width=\"305\" valign=\"top\" style=\"width:228.5pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;\">6<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;\">\u4f8b<\/span><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;\">CRC\u60a3\u8005\u7684\u6838\u5fc3\u548c\u8fb9\u7f18\u80bf\u7624\u533a\u57df\u4ee5\u53ca\u5339\u914d\u7684\u6b63\u5e38\u7c98\u819c\u768427,414\u4e2a\u7ec6\u80de\u7684\u5355\u7ec6\u80de3′ RNA\u6d4b\u5e8f\u6570\u636e<\/span><\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"94\" valign=\"top\" style=\"width:70.75pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">HRA000979<\/span><\/section>\n<\/td>\n<td width=\"90\" valign=\"top\" style=\"width:67.8pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;letter-spacing: 1px;\">GSA<\/span><\/section>\n<\/td>\n<td width=\"79\" valign=\"top\" style=\"width:59.05pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;letter-spacing: 1px;\">scRNA-seq<\/span><\/section>\n<\/td>\n<td width=\"305\" valign=\"top\" style=\"width:228.5pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;\"> 5\u540dCRC<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;\">\u60a3\u8005\u7684 scRNA-seq \u6570\u636e<\/span><\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"94\" valign=\"top\" style=\"width:70.75pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">E-MTAB-8107<\/span><\/section>\n<\/td>\n<td width=\"90\" valign=\"top\" style=\"width:67.8pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">ArrayExpress<\/span><\/section>\n<\/td>\n<td width=\"79\" valign=\"top\" style=\"width:59.05pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;letter-spacing: 1px;\">scRNA-seq<\/span><\/section>\n<\/td>\n<td width=\"305\" valign=\"top\" style=\"width:228.5pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">\u5375\u5de2\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u548c\u4e73\u817a\u764c\u7684\u5355\u7ec6\u80de RNA \u6d4b\u5e8f<\/span><\/section>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"94\" valign=\"top\" style=\"width:70.75pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">GSE178318<\/span><\/section>\n<\/td>\n<td width=\"90\" valign=\"top\" style=\"width:67.8pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;letter-spacing: 1px;\">GEO<\/span><\/section>\n<\/td>\n<td width=\"79\" valign=\"top\" style=\"width:59.05pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;font-family: Calibri;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;letter-spacing: 1px;\">scRNA-seq<\/span><\/section>\n<\/td>\n<td width=\"305\" valign=\"top\" style=\"width:228.5pt;background:#FFFFFF;border-top:solid #5B9BD5 1.0pt;mso-border-top-alt:solid #5B9BD5 0.5pt;border-left:solid #5B9BD5 1.0pt;mso-border-left-alt:solid #5B9BD5 0.5pt;border-bottom:solid #5B9BD5 1.0pt;mso-border-bottom-alt:solid #5B9BD5 0.5pt;border-right:solid #5B9BD5 1.0pt;mso-border-right-alt:solid #5B9BD5 0.5pt;padding:0pt 5.4pt 0pt 5.4pt;\">\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;break-before: auto;break-after: auto;word-break: normal;direction: ltr;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(0, 0, 0);font-weight: normal;vertical-align: baseline;font-size: 16px;letter-spacing: 1px;\">\u6cbb\u7597\u548c\u672a\u6cbb\u7597\u60a3\u8005\u7684CRC\u809d\u8f6c\u79fb\u7684\u5355\u7ec6\u80de\u8868\u8fbe\u8c31<\/span><\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u7814\u7a76\u601d\u8def<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u63d0\u51fa\u4e86SCORPION (single-cell Oriented Reconstruction of PANDA individual Optimized gene regulatory Networks)\uff0c\u8fd9\u662f\u4e00\u4e2a\u4f7f\u7528\u5355\u7ec6\u80de\/\u7ec6\u80de\u6838RNA-seq\u6570\u636e\u7c97\u7c92\u5ea6\u6765\u964d\u4f4e\u7a00\u758f\u6027\u5e76\u63d0\u9ad8\u68c0\u6d4b\u8fd9\u4e9b\u6570\u636e\u4e2d\u76f8\u5173\u7ed3\u6784\u80fd\u529b\u7684\u5de5\u5177\uff0c\u4f7f\u7528\u8c03\u8282\u7f51\u7edc\u91cd\u5efa\u7b97\u6cd5(PANDA)\u5c06\u751f\u6210\u7684\u7c97\u7c92\u5ea6\u6570\u636e\u7528\u4e8e\u91cd\u5efa\u57fa\u56e0\u8c03\u8282\u7f51\u7edc\u3002\u5229\u7528\u5408\u6210\u6570\u636e\u53d1\u73b0SCORPION\u4f18\u4e8e\u73b0\u6709\u768412\u79cd\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u91cd\u5efa\u6280\u672f\u3002\u901a\u8fc7\u76d1\u7763\u5b9e\u9a8c\uff0c\u4f5c\u8005\u53d1\u73b0SCORPION\u53ef\u4ee5\u51c6\u786e\u8bc6\u522b\u91ce\u751f\u578b\u548c\u8f6c\u5f55\u56e0\u5b50\u5e72\u6270\u7ec6\u80de\u4e4b\u95f4\u8c03\u8282\u7f51\u7edc\u7684\u5dee\u5f02\u3002\u4f7f\u7528\u542b200,436\u4e2a\u6765\u81ea\u7ed3\u76f4\u80a0\u764c\u548c\u90bb\u8fd1\u5065\u5eb7\u7ec4\u7ec7\u7684\u7ec6\u80de\u7684<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">scRNA-seq<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6d4b\u5e8f\u56fe\u8c31\uff0c\u8bc1\u660e\u4e86SCORPION\u5728\u7fa4\u4f53\u6c34\u5e73\u5206\u6790\u4e2d\u7684\u53ef\u6269\u5c55\u6027\u3002SCORPION\u68c0\u6d4b\u5230\u7684\u80bf\u7624\u5185\u548c\u80bf\u7624\u95f4\u533a\u57df\u4e4b\u95f4\u7684\u5dee\u5f02\u4e0e\u5df2\u6709\u7684\u5bf9\u5927\u591a\u6570\u7ed3\u80a0\u764c\u7684\u67d3\u8272\u4f53\u4e0d\u7a33\u5b9a\u9014\u5f84\uff08CIN\uff09\u75be\u75c5\u8fdb\u5c55\u7684\u7406\u89e3\u4e00\u81f4\uff0c\u5e76\u9610\u660e\u4e86\u53ef\u80fd\u5f71\u54cd\u60a3\u8005\u751f\u5b58\u7684\u8868\u578b\u8c03\u8282\u56e0\u5b50\u3002<\/span><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u4e3b\u8981\u7ed3\u679c<\/span><span style=\"font-size: 16px;letter-spacing: 1px;text-indent: 0pt;\">         <\/span><o:p style=\"font-size: 16px;letter-spacing: 1px;text-indent: 0pt;\"> <\/o:p><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">1.  SCORPION\u7b97\u6cd5<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"letter-spacing: 1px;font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">SCORPION\u901a\u8fc7\u4e94\u4e2a\u8fed\u4ee3\u6b65\u9aa4\uff0c\u4ece\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u4e2d\u751f\u6210\u53ef\u6bd4\u8f83\u7684\u3001\u5b8c\u5168\u8fde\u63a5\u7684\u3001\u52a0\u6743\u7684\u548c\u5b9a\u5411\u7684\u8f6c\u5f55\u7ec4\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff0c\u9002\u7528\u4e8e\u7fa4\u4f53\u6c34\u5e73\u7684\u7814\u7a76(\u56fe1a)\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u9996\u5148\u901a\u8fc7\u6298\u53e0k\u4e2a\u5728\u591a\u7ef4RNA-seq\u6570\u636e\u7684\u4f4e\u7ef4\u8868\u793a\u4e2d\u8bc6\u522b\u7684\u6700\u76f8\u4f3c\u7684\u7ec6\u80de\u3002\u7b2c\u4e8c\u6b65\u6784\u5efa\u4e09\u4e2a\u4e0d\u540c\u7684\u521d\u59cb\u672a\u7ec6\u5316\u7f51\u7edc\uff1a\u5171\u540c\u76d1\u7ba1\u7f51\u7edc\u3001\u5408\u4f5c\u7f51\u7edc\u548c\u76d1\u7ba1\u7f51\u7edc\u3002\u4e4b\u540e\u8bbe\u8ba1\u4e00\u4e2a\u4fee\u6539\u7248\u672c\u7684\u8c37\u672c\u76f8\u4f3c\u6027\u7528\u4e8e\u89e3\u91ca\u8fde\u7eed\u503c\u6765\u751f\u6210\u53ef\u7528\u6027\u7f51\u7edc(Aij)\uff0c\u8868\u793a\u4ece\u57fa\u56e0j\u5230\u8f6c\u5f55\u56e0\u5b50i\u7684\u4fe1\u606f\u6d41\u3002\u6b64\u5916\u901a\u8fc7\u8ba1\u7b97\u5408\u4f5c\u7f51\u7edc\u4e0e\u76d1\u7ba1\u7f51\u7edc\u7684\u76f8\u4f3c\u5ea6\uff0c\u751f\u6210\u8d23\u4efb\u7f51\u7edc(Rij)\uff0c\u8868\u793a\u4ece\u8f6c\u5f55\u56e0\u5b50i\u6d41\u5411\u57fa\u56e0j\u7684\u4fe1\u606f\u3002\u5728\u7b2c\u56db\u6b65\u4e2d\u8ba1\u7b97\u53ef\u7528\u6027\u548c\u8d23\u4efb\u7f51\u7edc\u7684\u5e73\u5747\u503c\uff0c\u5e76\u66f4\u65b0\u76d1\u7ba1\u7f51\u7edc\u3002\u5408\u4f5c\u548c\u5171\u540c\u76d1\u7ba1\u7f51\u7edc\u5728\u7b2c\u4e94\u6b65\u4e2d\u4f7f\u7528\u66f4\u65b0\u7684\u76d1\u7ba1\u7f51\u7edc\u4e2d\u5305\u542b\u7684\u65b0\u4fe1\u606f\u8fdb\u884c\u66f4\u65b0\u3002\u6b65\u9aa43\u5230\u6b65\u9aa45\u8fed\u4ee3\u91cd\u590d\uff0c\u76f4\u5230\u7f51\u7edc\u4e4b\u95f4\u7684\u6c49\u660e\u8ddd\u79bb\u8fbe\u5230\u7528\u6237\u5b9a\u4e49\u7684\u9608\u503c(\u9ed8\u8ba40.001)\u3002\uff08<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">ps\uff1a\u8bc4\u5206\u6a21\u578b\u53ef\u4ee5\u770b\u770b\u539f\u6587\u732e\u662f\u600e\u4e48\u505a\u7684\uff0c\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc\u53ef\u662f\u72ec\u7279\u7684\u52a0\u5206\u9879\u54e6\uff01<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\uff09<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010199\" data-ratio=\"0.5259259259259259\" data-type=\"png\" data-w=\"1080\" height=\"291 .2699890136719\" width=\"553 .5400390625\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_piameOc5xVTvXY0oE5KjiaI89zvhww.png?resize=553%2C291\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LTOPdIbQTQff3FRP1fvanVITOiacdnHs4741bx7xtGBqdWLrVxpiameOc5xVTvXY0oE5KjiaI89zvhww\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">\u56fe1  SCORPION\u53bb\u7a00\u758f\u5316\u7684\u6982\u8ff0\u548c\u57fa\u51c6<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">2.  \u4e0e\u73b0\u6709\u65b9\u6cd5\u7684\u6bd4\u8f83<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u6d4b\u8bd5<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">SCORPION<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4e0e\u5176\u4ed6\u7b97\u6cd5\u7684\u6027\u80fd\uff0c\u4f7f\u7528BEELINE\u5bf9\u7f51\u7edc\u6784\u5efa\u7b97\u6cd5\u8fdb\u884c\u4e86\u7cfb\u7edf\u6bd4\u8f83\u3002\u5bf9SCORPION\u8fdb\u884c12\u79cd\u4e0d\u540c\u7b97\u6cd5\u7684\u6d4b\u8bd5\u548c\u6bd4\u8f83\u3002SCORPION\u4ea7\u751f\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u7684\u7cbe\u786e\u5ea6\u548c\u7075\u654f\u5ea6\u63d0\u9ad818.75%\u3002\u6b64\u5916\u4f7f\u7528\u4e03\u4e2a\u4e0e\u7f51\u7edc\u6784\u5efa\u76f8\u5173\u7684\u4e0d\u540c\u6307\u6807\u7684\u5176\u4ed6\u65b9\u6cd5\u76f8\u6bd4\uff0cSCORPION\u59cb\u7ec8\u5e73\u5747\u6392\u540d\u7b2c\u4e00(\u56fe1b)\u3002<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u7531\u4e8e\u5c06\u8f6c\u5f55\u56e0\u5b50\u7ed3\u5408\u7684\u5148\u9a8c\u4fe1\u606f\u7eb3\u5165\u8c03\u63a7\u7f51\u7edc\u91cd\u5efa\u7b97\u6cd5\u53ef\u4ee5\u63d0\u9ad8\u5bf9\u8c03\u63a7\u7684\u9884\u6d4b\u3002\u4f5c\u8005\u6d4b\u8bd5SCORPION\u5728\u5408\u6210\u6570\u636e\u4e0a\u7684\u4f18\u5316\u65b9\u6cd5\u540e\uff0c\u5c06\u5b8c\u6574\u7684SCORPION\u6846\u67b6\u2014\u2014SuperCells\u548c\u4fe1\u606f\u5728\u5148\u524d\u7684\u76d1\u7ba1\u3001\u5408\u4f5c\u548c\u5171\u540c\u76d1\u7ba1\u7f51\u7edc\u4e4b\u95f4\u4f20\u9012\u2014\u2014\u76f4\u63a5\u5e94\u7528\u4e8e\u6574\u7406\u7684\u771f\u5b9e\u6570\u636e\u96c6\uff0c\u5e76\u8bc4\u4f30\u751f\u6210\u7684\u57fa\u56e0\u76d1\u7ba1\u7f51\u7edc\u7684\u751f\u7269\u5b66\u76f8\u5173\u6027\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">3.  \u68c0\u6d4b\u8f6c\u5f55\u56e0\u5b50\u6d3b\u6027\u7684\u53d8\u5316<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u4f5c\u8005\u4f7f\u7528\u4e24\u4e2a\u6570\u636e\u96c6\u8bc4\u4f30SCORPION\u3002\u6570\u636e\u96c6\u4e00\u901a\u8fc7\u53cc\u6572\u9664\u5b9e\u9a8c\u68c0\u6d4bHnf4\u03b1\u548cHnf4\u03b3\u8f6c\u5f55\u56e0\u5b50\u5728\u5c0f\u9f20\u80a0\u4e0a\u76ae\u4e2d\u7684\u5197\u4f59\u4f5c\u7528\u3002\u6570\u636e\u96c6\u4e8c\u7814\u7a76DUX4\u8f6c\u5f55\u56e0\u5b50\u8fc7\u8868\u8fbe\u5728\u4eba\u80da\u80ce\u5e72\u7ec6\u80de(ESCs)\u7684\u4f53\u5916\u4eba\u53d7\u7cbe\u5375\u57fa\u56e0\u7ec4\u6fc0\u6d3b\u6837\u8f6c\u5f55\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u6570\u636e\u96c6\u4e00\u6784\u5efa\u4e86\u4e24\u4e2a\u72ec\u7acb\u7684\u5355\u7ec6\u80de\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff0c\u4f5c\u8005\u4f7f\u7528\u4e24\u4e2a\u7f51\u7edc\u4e2d\u91cd\u53e0\u76842990\u4e2a\u57fa\u56e0\u7684\u8c03\u63a7\u673a\u5236\u7684\u5b50\u7f51\u7edc\u8fdb\u884c\u6bd4\u8f83\uff0c\u5173\u6ce8Hnf4\u03b1\u548cHnf4\u03b3\u8f6c\u5f55\u56e0\u5b50\u8fb9\u7f18\u6743\u91cd\u7684\u5dee\u5f02\u3002\u89c2\u5bdf\u5230\u53d7\u5e72\u6270\u7684\u8f6c\u5f55\u56e0\u5b50\u4e0e\u5176\u9776\u57fa\u56e0\u4e4b\u95f4\u7684\u94fe\u63a5<\/span><\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u6743\u91cd\u53d1\u751f\u4e86\u53d8\u5316(\u56fe2a,e)\u3002\u914d\u5bf9\u7684\u6743\u91cd\u5dee\u5f02\u663e\u8457\uff0c\u4e14\u4e0b\u8c03\u8d8b\u52bf\u4e00\u81f4(\u56fe2b,f)\u3002\u6572\u9664Hnf4\u03b1\u548cHnf4\u03b3\u540e\u5206\u522b\u53d1\u73b0221\u548c211\u4e2a\u5927\u53d8\u5316(\u56fe2c,g)\uff0c\u7a81\u51fa\u4e8684\u4e2a\u5171\u4eab\u57fa\u56e0\u7684\u6fc0\u6d3b\u4fe1\u53f7\u964d\u4f4e(\u4e0b\u8c03)\u3002\u4f7f\u7528\u8f6c\u5f55\u56e0\u5b50\u4e0e\u5176\u9776\u57fa\u56e0\u95f4\u7684\u8fde\u63a5\u6743\u91cd\u7684\u914d\u5bf9\u5dee\u5f02\u8fdb\u884cGSEA\u65f6\uff0c\u53d1\u73b0Hnf4\u03b1\u548cHnf4\u03b3\u6270\u52a8\u5bf9\u964d\u4f4e\u4e0e\u80a0\u7ec6\u80de\u540c\u6027\u53d1\u80b2\u76f8\u5173\u7684\u5178\u578b\u6807\u8bb0\u57fa\u56e0\u7684\u8868\u8fbe\u6709\u663e\u8457\u5f71\u54cd(\u56fe2d,h)\uff0c\u4e0e\u6570\u636e\u96c6\u7684\u539f\u7ed3\u8bba\u4e00\u81f4\u3002<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5bf9\u6570\u636e\u96c6\u4e8c\uff0c\u4f5c\u8005\u4e5f\u6784\u5efa\u4e24\u4e2a\u72ec\u7acb\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff0c\u6a21\u62df<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">WT<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4eba\u7c7bESCs\u7684\u8c03\u63a7\u673a\u5236\u53caDUX4\u8f6c\u5f55\u56e0\u5b50\u8fc7\u8868\u8fbe\u7684\u5f71\u54cd(\u56fe<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">2l)\u3002\u6bd4\u8f83\u4e24\u4e2a\u7f51\u7edc\u4e2dDUX4\u7684\u8f6c\u5f55\u56e0\u5b50\u6d3b\u6027\u65f6\uff0c<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u6ce8\u610f\u5230\u8f6c\u5f55\u56e0\u5b50\u8fc7\u8868\u8fbe\u524d\u540e\u94fe\u63a5\u6743\u91cd\u5206\u5e03\u7684\u53d8\u5316(\u56fe2j)\uff0cDUX4\u4e0e\u5176\u9776\u57fa\u56e0\u4e4b\u95f4\u7684\u8fde\u63a5\u6743\u7684\u6210\u5bf9\u5dee\u5f02\u663e\u8457\u5411\u6b63\u65b9\u5411\u79fb\u52a8(\u56fe2k)\uff0c\u8bf1\u5bfc\u5176\u9776\u57fa\u56e0\u4e0a\u8c03\u3002\u5229\u7528DUX4\u53ca\u5176\u9776\u57fa\u56e0\u4e4b\u95f4\u7684\u8fde\u9501\u6743\u7684\u914d\u5bf9\u5dee\u5f02\u8fdb\u884cGSEA\uff0c\u53d1\u73b0\u8fd9\u4e9b\u4e0e8c\u6837\u7ec6\u80de\u4e2d\u9ad8\u8868\u8fbe\u57fa\u56e0\u7684\u8fc7\u8868\u8fbe\u5448\u6b63\u76f8\u5173(\u56fe2<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">m)\u3002<\/span><\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u7efc\u4e0aSCORPION\u53ef\u4ee5\u68c0\u6d4b\u5230\u8f6c\u5f55\u56e0\u5b50\u6d3b\u6027\u7684\u5b9e\u9a8c\u9776\u5411\u53d8\u5316\uff0c\u5e76\u4ee3\u8868\u8fd9\u4e9b\u53d8\u5316\u5bf9\u7531\u6b64\u4ea7\u751f\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u7684\u5f71\u54cd\u3002   <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010200\" data-ratio=\"0.375\" data-type=\"png\" data-w=\"1080\" height=\"207 .33999633789062\" width=\"552 .8099975585938\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_9FA96icic77rUlKcXZbIQH165ffMBw.png?resize=552%2C207\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LTOPdIbQTQff3FRP1fvanVIumXER2yQBYk3lKTwib61ic7DZdHa9FA96icic77rUlKcXZbIQH165ffMBw\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><img decoding=\"async\" loading=\"lazy\" data-imgfileid=\"100010202\" data-ratio=\"0.33425925925925926\" data-type=\"png\" data-w=\"1080\" height=\"184 .79998779296875\" width=\"553 .6799926757812\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_VScZk0lTwO2dHqibVKvcAIRjtdbm7g.png?resize=553%2C184\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LTOPdIbQTQff3FRP1fvanVIrPEcXeTeianM0pneUj65yebpwNVScZk0lTwO2dHqibVKvcAIRjtdbm7g\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: normal;font-size: 16px;letter-spacing: 1px;\">\u56fe2  \u8bc4\u4f30SCORPION\u68c0\u6d4b\u8f6c\u5f55\u56e0\u5b50\u6d3b\u6027\u53d8\u5316\u53ca\u5176\u5bf9\u9776\u57fa\u56e0\u5f71\u54cd\u7684\u80fd\u529b<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">4.  \u53cd\u6620\u7ec6\u80de\u8eab\u4efd\u548c\u75be\u75c5\u72b6\u6001<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u6536\u96c65\u4e2a<\/span><\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;letter-spacing: 1px;\">\u516c\u5f00\u7684scRNA-seq\u6570\u636e\uff0c\u8d28\u63a7\u540e\u4fdd\u7559200,439\u4e2a(\u56fe3a-d)\u3002\u4f7f\u7528\u5178\u578b\u6807\u8bb0\u6ce8\u91ca\u7ec6\u80de\u540e\uff0c\u7528SCORPION\u4e3a\u56fe\u8c31\u4e2d\u6bcf\u4e2a\u6837\u672c\u4e2d\u7684\u6bcf\u79cd\u7ec6\u80de\u7c7b\u578b\u751f\u6210\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff0c\u5171\u6784<\/span><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5efa\u4e86560\u4e2a\u8f6c\u5f55\u7ec4\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff0c\u6bcf\u4e2a\u7f51\u7edc\u4e2d622\u4e2a\u8f6c\u5f55\u56e0\u5b50\u5bf917,425\u4e2a\u9776\u57fa\u56e0(\u603b\u8ba110,838,350\u4e2a\u94fe\u63a5)\u7684\u8c03\u63a7\u4f5c\u7528\u3002\u4f5c\u8005\u4f7f\u7528\u7f51\u7edc\u7684\u5ea6(\u4ece\u6240\u6709\u8f6c\u5f55\u56e0\u5b50\u5230\u4e00\u4e2a\u57fa\u56e0\u7684\u6743\u91cd\u4e4b\u548c)\u751f\u6210\u5305\u542b\u5728\u7f51\u7edc\u4e2d\u7684\u4fe1\u606f\u7684t\u5206\u5e03\u968f\u673a\u90bb\u5c45\u5d4c\u5165(t-SNE)\u4f4e\u7ef4\u8868\u793a\u3002\u53d1\u73b0\u65e0\u8bba\u54ea\u4e2a\u7ec4\u7ec7\uff0c\u76f8\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u7f51\u7edc\u90fd\u4f1a\u805a\u96c6\u5728\u4e00\u8d77(\u56fe3e)\u3002\uff08<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;color: rgb(46, 117, 182);font-weight: bold;\">ps\uff1a\u4e0d\u540c\u5de5\u5177\u7684\u5bf9\u6bd4\u53ef\u4ee5\u63d0\u9ad8\u6587\u7ae0\u8bf4\u670d\u529b\u54e6\uff0c\u60f3\u4e86\u89e3\u5b66\u4e60\u7684\u5feb\u6765@\u5c0f\u9014\u54df~~<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\uff09<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010203\" data-ratio=\"0.48703703703703705\" data-type=\"png\" data-w=\"1080\" height=\"269 .6000061035156\" width=\"553 .47998046875\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_bsBmyibRh4t6gMLZ52s5vrQOtic0IQ.png?resize=553%2C269\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LTOPdIbQTQff3FRP1fvanVI1CRiakrNm1fD1HpaO0Ta7CmRBV8bsBmyibRh4t6gMLZ52s5vrQOtic0IQ\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">\u56fe3  \u7ed3\u76f4\u80a0\u764c\u548c\u90bb\u8fd1\u5065\u5eb7\u7ec4\u7ec7\u8f6c\u5f55\u7ec4\u548c\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u7684\u4f4e\u7ef4\u8868\u793a<\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">          <o:p> <\/o:p><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">5.  \u63ed\u793a\u7ed3\u76f4\u80a0\u764c\u7684\u53d1\u5c55\u6a21\u5f0f<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4f5c\u8005\u5c06\u91cd\u70b9\u7814\u7a76\u7ed3\u76f4\u80a0\u764c\u4e2d\u9a71\u52a8\u4e0a\u76ae\u7ec6\u80de\u75be\u75c5\u8fdb\u5c55\u7684\u5206\u5b50\u673a\u5236\u3002\u5728\u56db\u79cd\u7ec4\u7ec7\u4e2d\u9009\u62e9\u4e86149\u4e2a\u5355\u7ec6\u80de\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff0c\u7528\u7ebf\u6027\u56de\u5f52\u7814\u7a76\u4e86622\u4e2a\u8f6c\u5f55\u56e0\u5b50\u4e0e15,325\u4e2a\u9776\u57fa\u56e0\u4e4b\u95f4\u76849,532,150\u4e2a\u94fe\u63a5\u3002\u4f5c\u8005\u63a8\u65ad\u5065\u5eb7\u7684\u90bb\u8fd1\u7ec4\u7ec7(\u7f16\u7801\u4e3a1)\u6cbf\u8fb9\u754c\u8fc7\u6e21\u8f6c\u5316\u4e3a\u6076\u6027\u7ec4\u7ec7(\u7f16\u7801\u4e3a2)\uff0c\u80bf\u7624\u6838\u5fc3\u7ec4\u7ec7(\u7f16\u7801\u4e3a3)\u548c\u8f6c\u79fb\u7ec4\u7ec7(\u7f16\u7801\u4e3a4)\u7684\u75be\u75c5\u4fe1\u53f7\u5c06\u589e\u52a0\u3002\u8ba1\u7b97\u03b2\u7cfb\u6570\u5e76\u5bf9\u6bcf\u4e2a\u73af\u8282\u7684\u591a\u91cd\u6d4b\u8bd5P\u503c\u8fdb\u884c\u4e86\u76f8\u5173\u8c03\u6574(\u56fe4a)\uff0c\u53d1\u73b05,202,588\u4e2a\u94fe\u63a5\u7684\u03b2\u7edd\u5bf9\u503c\u5927\u4e8e0\uff0c\u5e76\u5c06\u8fd9\u4e9b\u03b2\u7cfb\u6570\u4f5c\u4e3a\u751f\u6210\u7684\u4ee3\u8868\u7ed3\u76f4\u80a0\u764c\u8fdb\u5c55\u7684\u7f51\u7edc\u4e2d\u7684\u6743\u91cd(\u56fe5)\u3002\u4e00\u4e9b\u786e\u5b9a\u7684\u76f8\u4e92\u4f5c\u7528\u5177\u6709\u7ed3\u76f4\u80a0\u80bf\u7624\u751f\u957f\u548c\u53d1\u5c55\u6240\u5fc5\u9700\u7684\u81f4\u764c\u8f6c\u5316\u6a21\u5f0f\u4e00\u81f4\u7684\u65b9\u5411(\u56fe4a)\u3002\u8ba1\u7b97\u8f6c\u5f55\u56e0\u5b50\u7684\u603b\u4f53\u5173\u8054\u4f5c\u4e3a\u6bcf\u4e2a\u8f6c\u5f55\u56e0\u5b50\u4e0e\u5176\u9776\u57fa\u56e0\u7684\u6240\u6709\u03b2\u7cfb\u6570\u7684(\u5916\u5ea6)\u603b\u548c\u3002\u4f5c\u8005\u53d1\u73b0\u5728\u7ed3\u76f4\u80a0\u764c\u53d1\u751f\u8fc7\u7a0b\u4e2d\u4e0e\u4e4b\u6700\u76f8\u5173\u768410\u4e2a\u8f6c\u5f55\u56e0\u5b50\u548c\u8f93\u51fa\u5ea6\u964d\u4f4e\u7684\u524d<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">10\u4e2a<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u76f8\u5173\u8f6c\u5f55\u56e0\u5b50(\u56fe4b)\u3002\u4f5c\u8005\u8fd8\u901a\u8fc7\u7ebf\u6027\u56de\u5f52\uff0c\u4f7f\u7528\u805a\u5408\u6743\u91cd\u5411\u91cf\u8868\u793a\u6bcf\u4e2a\u57fa\u56e0\u5728\u75be\u75c5\u8fdb\u5c55\u671f\u95f4\u7684\u53d8\u5316\u7387\uff0c\u7136\u540e\u7528\u764c\u75c7\u7684\u6807\u5fd7\u8bc4\u4f30\u57fa\u56e0\u96c6\u5bcc\u96c6\u3002\u53d1\u73b0Hedgehog\u4fe1\u53f7\u3001Wnt\/\u03b2catenin\u4fe1\u53f7\u7b49\u7ed3\u76f4\u80a0\u764cCIN\u901a\u8def\u4e0a\u8c03\u3002<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u63a5\u4e0b\u6765\u4f5c\u8005\u8bc1\u660eSCORPION\u5728\u8bc6\u522b\u4e0d\u540c\u6761\u4ef6\u4e0b\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u5dee\u5f02\u65b9\u9762\u7684\u6f5c\u529b\u3002\u72ec\u7acb\u8ba1\u7b97\u6bcf\u4e2a\u7f51\u7edc\u4e2d622\u4e2a\u8f6c\u5f55\u56e0\u5b50\u4e2d\u7684\u6bcf\u4e2a\u8f6c\u5f55\u56e0\u5b50\u7684\u8f6c\u5f55\u56e0\u5b50\u9776\u5411(out\u5ea6)(\u56fe6a)\u3002\u6bd4\u8f83\u4e24\u7ec4\u53d1\u73b0118\u4e2a\u8f6c\u5f55\u56e0\u5b50\u5728\u53f3\u4fa7\u7ed3\u76f4\u80a0\u764c\u4e2d\u6d3b\u6027\u589e\u5f3a\uff0c\u800c\u5728\u5de6\u4fa7\u7ed3\u76f4\u80a0\u764c\u4e2d\u9776\u5411\u6027\u589e\u5f3a\u7684\u8f6c\u5f55\u56e0\u5b50\u4e3a287\u4e2a(\u56fe6b)\u3002\u5728\u5de6\u4fa7\u7ed3\u76f4\u80a0\u764c\u7684\u524d\u5341\u5927\u6d3b\u6027\u8f6c\u5f55\u56e0\u5b50\u4e2d(\u56fe6c)\uff0c\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u76f8\u5173\u7684\u8f6c\u5f55\u56e0\u5b50NFYA\u548cCEBPG\u663e\u8457\u5bcc\u96c6\u3002\u5728\u53f3\u4fa7\u7684\u7ec6\u80de\u4e2d(\u56fe6d)\uff0c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50(TNF)\u4fe1\u53f7\u76f8\u5173\u7684\u8f6c\u5f55\u56e0\u5b50\u901a\u8fc7\u6838\u56e0\u5b50\u03baB\u3002\u5206\u6790\u4e2d\u53d1\u73b0\u7684\u5de6\u53f3\u4e24\u4fa7\u7ed3\u76f4\u80a0\u764c\u5dee\u5f02\u6700\u663e\u8457\u7684\u9a71\u52a8\u56e0\u7d20\u5206\u522b\u662fZNF350\u548cNFKB2\u3002<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u4ea4\u53c9\u9a8c\u8bc1\u90e8\u5206\uff0c\u9996\u5148\u6bd4\u8f83TCGA<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: "Times New Roman";font-variant: normal;text-transform: none;\">-COAD\u548cTCGA-READ\u4e2d<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u5de6\u4fa7\u548c\u53f3\u4fa7\u7ed3\u76f4\u80a0\u764c\u7684\u539f\u53d1\u80bf\u7624\u60a3\u8005NFKB2\u8868\u8fbe\u7684\u5e73\u5747\u751f\u5b58\u7387\uff0c\u8bc1\u5b9e\u4e86NFKB2\u8868\u8fbe\u6c34\u5e73\u4e0e\u60a3\u8005\u5e73\u5747\u751f\u5b58\u7387\u7684\u76f8\u5173\u6027(\u56fe6 e)\u3002\u968f\u540e\u6bd4\u8f83\u4e86\u8fd9\u4e24\u79cd\u8f6c\u5f55\u56e0\u5b50\u5728\u80a0\u5de6\u4fa7\u548c\u53f3\u4fa7\u539f\u53d1\u6027\u7ed3\u76f4\u80a0\u80bf\u7624\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73(\u56fe6f,g)\u3002\u7efc\u4e0a\u5f3a\u8c03SCORPION\u4e0d\u4ec5\u80fd\u591f\u8bc6\u522b\u5f71\u54cd\u60a3\u8005\u751f\u5b58\u7684\u80bf\u7624\u5185\u7279\u5f81\uff0c\u8fd8\u80fd\u591f\u8bc6\u522b\u65b0\u7684\u751f\u7269\u6807\u5fd7\u7269\u548c\u9002\u5f53\u7684\u9776\u6807\uff0c\u4e3a\u60a3\u8005\u5f00\u53d1\u836f\u7269\u9009\u62e9\u3002<\/span><\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010204\" data-ratio=\"0.6324074074074074\" data-type=\"png\" data-w=\"1080\" height=\"349 .94000244140625\" width=\"553 .6099853515625\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/9_INpMwj8hKZqCxrXrDXmsRCKmMSR0bw.png?resize=553%2C349\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LTOPdIbQTQff3FRP1fvanVIicPlOtnrgEibeM7BaicOib8AvOlaINpMwj8hKZqCxrXrDXmsRCKmMSR0bw\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;\">\u56fe4  \u7ed3\u76f4\u80a0\u764c\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\u4e0a\u76ae\u7ec6\u80de\u5dee\u5f02\u7f51\u7edc\u5206\u6790<\/span>    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010206\" data-ratio=\"1.001031991744066\" data-type=\"png\" data-w=\"969\" height=\"496 .4100341796875\" width=\"497 .010009765625\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/10_mGk95TwZMRMUr2cN7apDMasUMViang.png?resize=497%2C496\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LTOPdIbQTQff3FRP1fvanVIhazAliaALHiaJQiapOLUhkSMAB8hmGk95TwZMRMUr2cN7apDMasUMViang\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">\u56fe5  \u7ed3\u76f4\u80a0\u764c\u8fdb\u5c55\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: Calibri;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\"><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010207\" data-ratio=\"0.47314814814814815\" data-type=\"png\" data-w=\"1080\" height=\"260 .94000244140625\" width=\"552 .2100219726562\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/11_rLH9wGXzJonOUiagSTOEib5YZWdofA.png?resize=552%2C260\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LTOPdIbQTQff3FRP1fvanVIj3wqLO3iaKjrV0GjtEYpVicO96f8rLH9wGXzJonOUiagSTOEib5YZWdofA\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><img decoding=\"async\" loading=\"lazy\" class=\"rich_pages wxw-img\" data-imgfileid=\"100010205\" data-ratio=\"0.6185185185185185\" data-type=\"png\" data-w=\"1080\" height=\"341 .6700134277344\" width=\"552 .5399780273438\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/12_0KAftoMoTRLhia8ZByzoqkaw99pbUw.png?resize=552%2C341\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/hud5kpqc1LTOPdIbQTQff3FRP1fvanVIfEqaEHq59gF9KcP4ict1KHhMPd0KAftoMoTRLhia8ZByzoqkaw99pbUw\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/span><span style=\"font-size: 16px;letter-spacing: 1px;\">    <\/span><o:page><\/o:page><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-size: 16px;letter-spacing: 1px;\">\u56fe6  \u5de6\u53f3\u4e24\u4fa7\u7ed3\u76f4\u80a0\u764c\u4e0a\u76ae\u7ec6\u80de\u7684\u8c03\u8282\u5dee\u5f02<\/span><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><br \/><\/section>\n<section style=\"margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;text-align: justify;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;font-size: 16px;letter-spacing: 1px;\">\u6587\u7ae0\u5c0f\u7ed3<\/span><\/section>\n<section style=\"text-align: justify;margin-left: 0pt;text-indent: 0pt;font-size: 10.5pt;font-family: Calibri;font-weight: normal;margin-top: 8px;margin-bottom: 24px;line-height: 1.6em;\"><span style=\"font-size: 16px;letter-spacing: 1px;\"><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;text-decoration: none;\">\u5fc3\u52a8\u4e86\u5417\uff01\u7fa1\u6155\u4e86\u5417\uff01\u540d\u526f\u5176\u5b9e\u7684SCORPION\u5de5\u5177\uff0c\u5728\u5176\u4ed6\u65b9\u5411\u7684\u751f\u4fe1\u5206\u6790\u4e2d\u4e5f\u662f\u80fd\u5927\u653e\u5f02\u5f69\u7684\u5462\uff01<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;text-decoration: none;background: rgb(255, 255, 0);\">\u6709\u505a\u76f8\u4f3c\u7c7b\u578b\u7814\u7a76\u7684\u5c0f\u4f19\u4f34\u53ef\u8981\u6293\u7d27\u4e86\uff0c\u8bf4\u4e0d\u5b9a\u5c0f\u9014\u4e0b\u4e00\u7bc7\u5c31\u8981\u5411\u5927\u5bb6\u63a8\u9001\u4f60\u7684\u6587\u7ae0\u54e6\uff01<\/span><span style=\"font-size: 16px;line-height: 150%;font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;color: rgb(255, 0, 0);font-weight: bold;text-decoration: none;background: rgb(255, 255, 0);\">\u60f3\u4e3a\u81ea\u5df1\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u5206\u6790\u518d\u63d0\u63d0\u901f\uff1f\u6216\u8005\u60f3\u5e94\u7528\u5728\u5176\u4ed6\u7684\u75be\u75c5\u5206\u6790\u5417\uff1f\u4e13\u4e1a\u7684\u5c0f\u9014\u4e00\u5b9a\u5e2e\u4f60\u5b9e\u73b0\u51b2\u5206\uff01<\/span><\/span><\/section>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018240\" data-ratio=\"1\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/13_B2jkicacLzPjw4xMSqVvoucZjonVDA-8.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg&from=appmsg'\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018242\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/14_7TvAyUibd1TPhJmZfialJtv6tu2SEg-9.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-recalc-dims=\"1\" \/><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100018241\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/15_9N02aBaau07RufXeXRLmvAHsrFZxtw-7.jpg?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-recalc-dims=\"1\" \/><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" 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