{"id":60006,"date":"2024-06-17T10:40:21","date_gmt":"2024-06-17T02:40:21","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=60006"},"modified":"2024-06-17T10:40:21","modified_gmt":"2024-06-17T02:40:21","slug":"buff%e5%8f%a0%e6%bb%a1%e4%ba%86%ef%bc%81%e4%b8%ad%e5%8c%bb%e8%8d%af%e5%8d%95%e7%bb%86%e8%83%9e%e9%93%81%e6%ad%bb%e4%ba%a1%e9%9d%9e%e8%82%bf%e7%98%a4%e7%96%be%e7%97%85%ef%bc%81%ef%bc%81%e7%ac%ac-2","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=60006","title":{"rendered":"Buff\u53e0\u6ee1\u4e86\uff01\u4e2d\u533b\u836f+\u5355\u7ec6\u80de+\u94c1\u6b7b\u4ea1+\u975e\u80bf\u7624\u75be\u75c5\uff01\uff01\u7b2c\u56db\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u4e01\u4e00\u56e2\u961f\u4e2d\u79d1\u9662\u4e8c\u533a9.3\u5206\uff01\u52a9\u529b\u4e2d\u533b\u836f\u521b\u9020\u65b0\u8f89\u714c\uff01"},"content":{"rendered":"


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onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6q2QVQ4SJ12mNjryuyTyeGMB7xbJSKGrbP2USbQ0pAeDIbt2aIJH0ZymhkrUfSlOTKZ326hqZp9w\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" height=\"242.5999755859375\" width=\"553.739990234375\"><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span>    <o:page><\/o:page><\/p>\n<p style=\"text-align: justify;text-indent: 0pt;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-bidi-font-weight:bold;\">\u9898\u76ee\uff1a\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5b66\u63ed\u793a\u4e8611-\u916e-\u03b2-\u4e73\u9999\u9178\u548cz -\u8c37\u53e4\u916e\u5bf9\u7f3a\u8840\u6027\u5352\u4e2d\u7684\u65b0\u534f\u540c\u4f5c\u7528\u673a\u5236<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0pt;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-bidi-font-weight:bold;\">\u6742\u5fd7\uff1aPharmacol Res<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0pt;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-bidi-font-weight:bold;\">\u5f71\u54cd\u56e0\u5b50\uff1aIF=9.3<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0pt;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;mso-bidi-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;mso-bidi-font-weight:bold;\">\u53d1\u8868\u65f6\u95f4\uff1a2023\u5e745\u670823\u65e5<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0pt;margin-bottom: 24px;\"><span 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Roman;font-variant:normal;text-transform:none;\">\u5355\u7ec6\u80deRNA\u6d4b\u5e8f(scRNA-seq)\u4f5c\u4e3a\u751f\u547d\u79d1\u5b66\u63a2\u7d22\u524d\u6cbf\u7684\u4e00\u79cd\u65b0\u5174\u6280\u672f\uff0c\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u764c\u75c7\u3001\u795e\u7ecf\u751f\u7269\u5b66\u3001\u80da\u80ce\u53d1\u80b2\u3001\u514d\u75ab\u5b66\u7b49\u9886\u57df\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0cMCAO\u5c0f\u9f20\u5206\u522b\u7528KBA\u3001Z-GS\u6216\u5176\u6df7\u5408\u7269\u5904\u7406\u3002\u7136\u540e\u53d6\u7f3a\u8840\u534a\u6697\u533a\u7ec4\u7ec7\u8fdb\u884cscRNA-seq\u5206\u6790\uff0c\u4ee5\u63ed\u793aKBA\u4e0eZ-GS\u7684\u534f\u540c\u4f5c\u7528\u673a\u5236\u3002<\/span><\/p>\n<p style=\"text-indent: 24.1pt;text-align: center;margin-bottom: 24px;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);\">\u7814\u7a76\u601d\u8def<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u672c\u7814\u7a76\u91c7\u7528\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5b66\u65b9\u6cd5\u7814\u7a76KBA\u548cZ-GS\u5bf9\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u7684\u534f\u540c\u4f5c\u7528\u53ca\u5176\u673a\u5236\u3002\u8be5\u7814\u7a76\u5206\u4e3a\u4e24\u90e8\u5206\uff1a<\/span>    <o:page><\/o:page><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">(1)\u5efa\u7acbMCAO\u5c0f\u9f20\u6a21\u578b\u5e76\u7ed9\u4e88\u76f8\u5e94\u836f\u7269\u540e\uff0c\u9996\u5148\u5bf9\u53d6\u51fa\u7684\u8111\u7ec4\u7ec7\u8fdb\u884c\u795e\u7ecf\u529f\u80fd\u8bc4\u5206\u4e0e\u514d\u75ab\u8367\u5149\u67d3\u8272\uff0c\u518d\u5206\u79bb\u51fa\u5c0f\u9f20\u8111\u5355\u7ec6\u80de\u5236\u6210\u60ac\u6db2\u540e\u8fdb\u884cscRNA-seq\u5206\u6790\uff0c\u63a5\u7740\u4f7f\u752810\u00d7Genomics Cell Ranger Single Cell 3.0.1 pipeline\u5bf9scRNAseq\u6570\u636e\u8fdb\u884c\u5904\u7406\uff0c\u4f7f\u7528Seurat (version 2.3.1) R\u8f6f\u4ef6\u5305\u901a\u8fc7PCA\u548ct-SNE\u8fdb\u884c\u964d\u7ef4\uff0c\u7136\u540e\u786e\u5b9a\u7ec6\u80de\u7c07\u3002<\/span><\/p>\n<section style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">(2)\u901a\u8fc7\u6280\u672f\u83b7\u5f97\u5c0f\u9f20\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u5171\u540c\u57f9\u517b\u5e76\u8fdb\u884c\u77ed\u6682\u6c27\u7cd6\u5265\u593a(OGD)\uff0c\u63a5\u7740\u8fdb\u884cscRNA-seq\u5206\u6790\u4e0eWestern blotting\u3002<\/span><span style=\"font-family: "Times New Roman";text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\">        <\/span><o:p style=\"font-family: "Times New Roman";text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\"> <\/o:p><span style=\"font-family: "Times New Roman";text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\"><\/span><\/section>\n<p style=\"text-indent: 24.1pt;text-align: center;margin-bottom: 24px;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);\">\u4e3b\u8981\u7ed3\u679c<\/span><\/p>\n<p style=\"text-indent: 24.1pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">KBA+Z-GS\u5904\u7406\u7684\u7f3a\u8840\u534a\u6697\u533a\u5171\u9274\u5b9a\u51fa14\u79cd\u7ec6\u80de\u7c7b\u578b<\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u56fe2A\u4e3a\u5355\u7ec6\u80de\u6d4b\u5e8f\u6d41\u7a0b\u793a\u610f\u56fe\u3002\u4f5c\u8005\u5229\u7528\u8f6c\u5f55\u7ec4\u7279\u5f81\uff0c\u5728\u8fc7\u6ee4\u6389\u4f4e\u8d28\u91cf\u7ec6\u80de\u540e\uff0c\u5bf9\u7ec6\u80de\u7c7b\u578b\u8fdb\u884c\u5206\u7c7b\uff0c\u6700\u7ec8\u5f97\u523031872\u4e2a\u9ad8\u8d28\u91cf\u7ec6\u80de\uff0c\u6309\u7167\u76f8\u4f3c\u7684\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\u5206\u621025\u4e2a\u7ec6\u80de\u7c07(\u56fe2B)\u3002\u901a\u8fc7\u4ea4\u53c9\u53c2\u8003\u6bcf\u4e2a\u7c07\u7279\u6709\u7684\u57fa\u56e0\u7279\u5f81\u548cCellMarker\u6570\u636e\u5e93\u4e2d\u7684\u7ec6\u80de\u7279\u5f81\u5c06\u7ec6\u80de\u5206\u7c7b\u4e3a14\u4e2a\u539f\u4ee3\u7ec6\u80de\u7cfb(\u56fe2B\u548c2C)\u3002\u7531\u56fe\u53ef\u77e5\uff0cMCAO\u7ec4\u548c\u7ed9\u836f\u7ec4\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u5206\u5e03\u660e\u663e\u4e0d\u540c\uff0c\u8fd9\u8868\u660eKBA\u548cZ-GS\u5904\u7406\u5bf9\u5404\u79cd\u7ec6\u80de\u7c7b\u578b\u7684\u4e30\u5ea6\u5177\u6709\u8c03\u8282\u4f5c\u7528(\u56fe2D\u548c2F)\u3002\u5728\u8fd914\u79cd\u7ec6\u80de\u7c7b\u578b\u4e2d\uff0c\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6240\u5360\u6bd4\u4f8b\u6700\u5927\uff0c\u5206\u522b\u4e3a33%\u548c24%(\u56fe2E)\u3002<\/span> 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onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6q2QVQ4SJ12mNjryuyTyeG6PShLPKKtprFKJvZ2UDhAN6a668llufocR8ic8OASWmJX7sQfxN11ZQ\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"714\" style=\"width: 446px;height: 553px;\"><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"text-indent: 24.1pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">KBA-Z-GS\u8c03\u8282\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e9a\u578b\u7684\u7ec6\u80de\u4ee3\u8c22\u548c\u51cb\u4ea1<\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e3a\u4e86\u8fdb\u4e00\u6b65\u9610\u660e\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u591a\u6837\u6027\uff0c\u5c06MCAO\u7ec4\u3001KBA\u7ec4\u3001Z-GS\u7ec4\u3001KBA\uff0bZ-GS\u56db\u7ec4\u768410525\u4e2a\u7ec6\u80de\u8fdb\u4e00\u6b65\u805a\u7c7b\uff0c\u4ece\u800c\u9274\u5b9a\u51fa11\u4e2a\u4e0d\u540c\u7684\u4e9a\u7c07\u3002\u7136\u540e\uff0c\u6839\u636e\u7279\u5b9a\u7684\u6807\u8bb0\u57fa\u56e0\u8868\u8fbe\uff0c\u5c06\u5b83\u4eec\u9274\u5b9a\u4e3a6\u79cd\u4e9a\u578b (\u56fe3A\u548c3B)\u3002MCAO\u548cKBA-Z-GS\u6cbb\u7597\u7ec4\u5728\u5176\u4e9a\u578b\u4e2d\u8868\u73b0\u51fa\u663e\u8457\u7684\u5dee\u5f02(\u56fe3C)\u3002\u7ec6\u80de\u4e9a\u7fa4\u6bd4\u4f8b\u56fe\u6240\u793a\uff0cKBA-Z-GS\u5904\u7406\u6837\u54c1\u4e2dTtr<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e9a\u578b\u7ec6\u80de\u66f4\u4e30\u5bcc(\u56fe3D)\u3002<\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u63a5\u4e0b\u6765\uff0c\u91c7\u7528GSVA\u5206\u6790\u6bcf\u4e2a\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e9a\u578b\u5728\u63a5\u53d7KBA-Z-GS\u5904\u7406\u65f6\u7684\u53cd\u5e94(\u56fe3E)\u3002\u901a\u8fc7\u5206\u6790tr<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e0a\u8c03\u7684DEGs\u548cRab7b<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e0b\u8c03\u7684DEGs\uff0c\u4ece\u4e2d\u7b5b\u9009\u51fa74\u4e2a\u4ea4\u53c9\u57fa\u56e0(\u56fe3F)\u3002\u529f\u80fd\u5206\u6790\u8868\u660e\uff0c\u8fd974\u4e2a\u5dee\u5f02\u57fa\u56e0\u4e0e\u547c\u5438\u7535\u5b50\u4f20\u9012\u94fe\u3001\u6c27\u5316\u78f7\u9178\u5316\u3001ATP\u4ee3\u8c22\u8fc7\u7a0b\u7b49\u8fc7\u7a0b\u5bc6\u5207\u76f8\u5173\u3002\u6b64\u5916\uff0c\u5728tr<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e0b\u8c03\u7684DEGs\u548cRab7b<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e0a\u8c03\u7684DEGs\u4e2d\uff0c\u7b5b\u9009\u5230223\u4e2a\u4e0e\u7ec6\u80de\u6b7b\u4ea1\u3001\u7ec6\u80de\u5206\u5316\u3001\u7ec6\u80de\u53d1\u80b2\u8fc7\u7a0b\u548c\u51cb\u4ea1\u8fc7\u7a0b\u76f8\u5173\u7684\u5171\u6709\u57fa\u56e0(\u56fe3G)\u3002\u7ed3\u679c\u63d0\u793aKBA-Z-GS\u53ef\u80fd\u901a\u8fc7\u8c03\u8282\u7ec6\u80de\u4ee3\u8c22\u548c\u51cb\u4ea1\u5bf9Ttr<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u548cRab7b<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e9a\u578b\u53d1\u6325\u4fdd\u62a4\u4f5c\u7528\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"text-align: justify;text-indent: 0pt;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"415\" data-cropsely1=\"0\" data-cropsely2=\"512\" data-imgfileid=\"100017995\" data-ratio=\"1.2349726775956285\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-26_\u300c\u8f6c\u300dBuff\u53e0\u6ee1\u4e86\uff01\u4e2d\u533b\u836f+\u5355\u7ec6\u80de+\u94c1\u6b7b\u4ea1+\u975e\u80bf\u7624\u75be\u75c5\uff01\uff01\u7b2c\u56db\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u4e01\u4e00\u56e2\u961f\u4e2d\u79d1\u9662\u4e8c\u533a93\u5206\uff01\u52a9\u529b\u4e2d\u533b\u836f\u521b\u9020\u65b0\u8f89\u714c\uff01\/5_JBM6s1lf5iaRu8mEJ1uJUVIlwUwekA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6q2QVQ4SJ12mNjryuyTyeGhb4niblunUJvD7iaDxjb6fu9AianJBM6s1lf5iaRu8mEJ1uJUVIlwUwekA\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"732\" style=\"width: 415px;height: 513px;\"><span style=\"text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\">         <\/span><o:p style=\"text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\"> <\/o:p><\/span><span style=\"font-family: "Times New Roman";text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\"><\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">KBA+Z-GS\u534f\u540c\u8c03\u8282MCAO\u5c0f\u9f20\u5c0f\u80f6\u8d28\u7ec6\u80de\u708e\u75c7\u53cd\u5e94<\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New 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style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e3a\u4e86\u66f4\u597d\u5730\u89e3\u91caKBA\u548cZ-GS\u7684\u534f\u540c\u4f5c\u7528\uff0c\u4f5c\u8005\u5efa\u7acb\u4e86\u4e00\u79cd\u521b\u65b0\u7684\u836f\u7269-\u57fa\u56e0\u534f\u540c\u8c03\u63a7\u6a21\u5f0f\uff0c\u5c06KBA+Z-GS\u8c03\u63a7\u7684\u57fa\u56e0\u5206\u4e3a4\u7c7b\uff1a\u589e\u6548-\u6709\u76ca\u57fa\u56e0(EEBGs)\u3001\u589e\u6548-\u6709\u5bb3\u57fa\u56e0(EEHGs)\u3001\u51cf\u6bd2-\u6709\u76ca\u57fa\u56e0(TRBGs)\u3001\u51cf\u6bd2-\u6709\u5bb3\u57fa\u56e0(TRHGs)\u3002\u6839\u636e\u8be5\u6a21\u5f0f\u5206\u522b\u7b5b\u900959\u3001117\u30010\u548c2\u4e2aDEGS(\u56fe6 J)\u3002\u4ee3\u8868\u6027DEGS\u4e3aSpp1 \u7684EEBGs\u3001Rnf169\u7684 EEHGs\u3001Rps23 \u7684 TRHGs (\u56fe6 K)\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"text-align: justify;text-indent: 0pt;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"430\" data-cropsely1=\"0\" data-cropsely2=\"335\" data-imgfileid=\"100017994\" data-ratio=\"1.2863070539419088\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-26_\u300c\u8f6c\u300dBuff\u53e0\u6ee1\u4e86\uff01\u4e2d\u533b\u836f+\u5355\u7ec6\u80de+\u94c1\u6b7b\u4ea1+\u975e\u80bf\u7624\u75be\u75c5\uff01\uff01\u7b2c\u56db\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u4e01\u4e00\u56e2\u961f\u4e2d\u79d1\u9662\u4e8c\u533a93\u5206\uff01\u52a9\u529b\u4e2d\u533b\u836f\u521b\u9020\u65b0\u8f89\u714c\uff01\/6_W4icfdNz6sEEsHrkNic6yu2OkDmbMA.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6q2QVQ4SJ12mNjryuyTyeGJlRSlaBfJ1dVXNbibhGmZqRfZSTW4icfdNz6sEEsHrkNic6yu2OkDmbMA\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"723\" style=\"width: 430px;height: 553px;\"><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">KBA+Z-GS\u8c03\u8282\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e9a\u578b\u7684\u51cb\u4ea1\u548c\u795e\u7ecf\u7cfb\u7edf\u53d1\u80b2<\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u5728KBA+Z-GS\u8bf1\u5bfc\u540e\u68c0\u6d4b\u5230\u76847718\u4e2a\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e2d\uff0c\u4ece11\u4e2a\u4e9a\u7c07\u4e2d\u9274\u5b9a\u51fa7\u4e2a\u4e9a\u578b (\u56fe7B)\u3002\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e9a\u578b\u5728\u4e0d\u540c\u6837\u54c1\u4e2d\u7684\u6bd4\u4f8b\u5982\u56fe7C-7D\u6240\u793a\u3002KBA\u7ec4Slc7a1<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u548cTtr<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e9a\u578b\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6bd4Z-GS\u7ec4\u66f4\u4e30\u5bcc\uff0c\u800cApod<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e9a\u578b\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e3b\u8981\u5206\u5e03\u5728MCAO\u7ec4\u3002<\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">GSVA\u7ed3\u679c\u663e\u793a\uff0c KBA+Z-GS\u7ec4Ttr<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u548cSt6galnac5<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e9a\u578b\u5177\u6709\u4e0d\u540c\u7684\u529f\u80fd (\u56fe7E)\u3002Ttr<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e0a\u8c03\u7684DEGs\u548cSt6galnac5<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e0b\u8c03\u7684DEGs\u4e2d\u768415\u4e2a\u5171\u6709\u57fa\u56e0\u5982\u56fe7 F\u3002Ttr<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e0b\u8c03\u7684DEGs\u548cSt6galnac5<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e0a\u8c03\u7684DEGs\u7684186\u4e2a\u5171\u6709\u57fa\u56e0\u5982\u56fe7G\u3002\u4ece\u56fe\u53ef\u77e5\uff0c\u5171\u6709\u57fa\u56e0\u4e3b\u8981\u4e0e\u795e\u7ecf\u5143\u7684\u53d1\u80b2\u548c\u5206\u5316\u4ee5\u53ca\u795e\u7ecf\u7cfb\u7edf\u7684\u4ea7\u751f\u548c\u53d1\u751f\u6709\u5173\u3002\u4e0a\u8ff0\u6570\u636e\u8868\u660e\uff0cTtr<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u53ef\u80fd\u662fKBA+Z-GS\u7ec4\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684\u4e00\u4e2a\u5173\u952e\u4e9a\u578b\uff0cKBA+Z-GS\u53ef\u4ee5\u901a\u8fc7Ttr<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><sup>hi<\/sup><\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u6291\u5236MCAO\u5c0f\u9f20\u7ec6\u80de\u51cb\u4ea1\u5e76\u4fc3\u8fdb\u5176\u795e\u7ecf\u7cfb\u7edf\u53d1\u80b2\u53d1\u6325\u4fdd\u62a4\u4f5c\u7528\u3002<\/span>    <span style=\"font-family: "Times New Roman";text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\">         <\/span><o:p style=\"font-family: "Times New Roman";text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\"> <\/o:p><span style=\"font-family: "Times New Roman";text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\"><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0pt;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"445\" data-cropsely1=\"0\" data-cropsely2=\"357\" data-imgfileid=\"100017997\" data-ratio=\"1.2456140350877194\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-26_\u300c\u8f6c\u300dBuff\u53e0\u6ee1\u4e86\uff01\u4e2d\u533b\u836f+\u5355\u7ec6\u80de+\u94c1\u6b7b\u4ea1+\u975e\u80bf\u7624\u75be\u75c5\uff01\uff01\u7b2c\u56db\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u4e01\u4e00\u56e2\u961f\u4e2d\u79d1\u9662\u4e8c\u533a93\u5206\uff01\u52a9\u529b\u4e2d\u533b\u836f\u521b\u9020\u65b0\u8f89\u714c\uff01\/7_WPoiadLKMeWob5MicvKkdCECu7C78Q.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6q2QVQ4SJ12mNjryuyTyeG2aIhPgdLCf3ibwZ1eY9eTkmHs78WPoiadLKMeWob5MicvKkdCECu7C78Q\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"741\" style=\"width: 445px;height: 554px;\"><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0pt;margin-bottom: 24px;\"><span style=\"text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;font-family: "Times New Roman";font-weight: bold;\">KBA+Z-GS\u534f\u540c\u8c03\u8282MCAO\u5c0f<\/span><span style=\"text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;font-family: "Times New Roman";font-weight: bold;\">\u9f20\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u94c1\u6b7b\u4ea1<\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5206\u6790\u4e86KBA\u548cZ-GS\u8054\u5408\u7528\u836f\u4e0e\u5355\u72ec\u7528\u836f\u5728\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e2d\u7684DEGs\u3002\u4e0eKBA\u7ec4\u76f8\u6bd4\uff0cKBA+Z-GS\u7ec4\u5408\u4e0a\u8c03\u57fa\u56e0358\u4e2a\uff0c\u4e0b\u8c03\u57fa\u56e0339\u4e2a (\u56fe10A)\u3002Grm3\u548cMt2\u5206\u522b\u4e3a\u4e0a\u8c03\u4e0e\u4e0b\u8c03\u6700\u591a\u7684DEGs (\u56fe10B)\uff0c\u6839\u636eGSVA\u5206\u6790\uff0cGrm3\u548cMt2 \u57fa\u56e0\u4e3b\u8981\u6d89\u53ca\u201c\u8c37\u80f1\u7518\u80bd\u4ee3\u8c22\u201d\u3001\u201c\u6838\u7cd6\u4f53\u201d\u548c\u201c\u86cb\u767d\u9176\u4f53\u201d\u9014\u5f84(\u56fe10C)\uff0c\u8fd9\u4e0e\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u7ed3\u679c\u76f8\u4f3c\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u4e0eZ-GS\u7ec4\u76f8\u6bd4\uff0cKBA+Z-GS\u7ec4\u5408\u4e0a\u8c03\u57fa\u56e090\u4e2a\uff0c\u4e0b\u8c03\u57fa\u56e066\u4e2a (\u56fe10D)\u3002Serpina3n\u548cNebl\u5206\u522b\u4e3a\u4e0a\u8c03\u4e0e\u4e0b\u8c03\u6700\u591a\u7684DEGs (\u56fe10E)\u3002\u6839\u636eGSVA\u5206\u6790\uff0cSerpina3n\u548cNebl 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KBA\u4e0eZ-GS\u8054\u5408\u6216\u5355\u72ec\u7ed9\u836f\u65f6\u661f\u5f62\u80f6\u8d28\u7ec6\u80de88\u4e2aDEGs\u7684\u7ef4\u6069\u56fe\u5982\u56fe10G\uff0c\u8fd9\u4e9b\u57fa\u56e0\u53c2\u4e0e\u4e86\u94c1\u6b7b\u4ea1\u8fc7\u7a0b(\u56fe10H)\u3002\u514d\u75ab\u8367\u5149\u67d3\u8272\u7ed3\u679c\u663e\u793a\uff0cMCAO\u7ec4\u94c1\u6b7b\u4ea1\u751f\u7269\u6807\u5fd7\u7269Fth1\u8868\u8fbe\u964d\u4f4e\u3002\u7136\u800c\uff0cKAB\u548cZ-GS\u7684\u4f7f\u7528\u5bfc\u81f4Fth1\u6c34\u5e73\u663e\u8457\u5347\u9ad8(\u56fe10I)\u3002\u6700\u540e\uff0c\u4f5c\u8005\u8fd8\u901a\u8fc7\u836f\u7269-\u57fa\u56e0\u534f\u540c\u8c03\u63a7\u6a21\u5f0f\u786e\u5b9a\u4e86\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e2dKBA-Z-GS\u8c03\u63a7\u76844\u7ec4\u7684DEGs (\u56fe10 J)\uff0c\u4ee3\u8868\u57fa\u56e0\u4e3aeebg\u7684Spp1\u3001eehg\u7684Far1\u3001trbg\u7684Gpc5\u548ctrhg\u7684Ubc(\u56fe10 K)\u3002<\/span><span style=\"text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;\">         <\/span><span style=\"text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;font-family: "Times New Roman";font-variant-numeric: normal;font-variant-east-asian: normal;\">        <o:p> <\/o:p><\/span><span style=\"text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\">   <\/span><span style=\"text-indent: 0pt;font-size: var(--articleFontsize);letter-spacing: 0.034em;\"><\/span><\/p>\n<p style=\"text-align: justify;text-indent: 0pt;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"434\" data-cropsely1=\"0\" data-cropsely2=\"340\" data-imgfileid=\"100017998\" data-ratio=\"1.276243093922652\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-26_\u300c\u8f6c\u300dBuff\u53e0\u6ee1\u4e86\uff01\u4e2d\u533b\u836f+\u5355\u7ec6\u80de+\u94c1\u6b7b\u4ea1+\u975e\u80bf\u7624\u75be\u75c5\uff01\uff01\u7b2c\u56db\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u4e01\u4e00\u56e2\u961f\u4e2d\u79d1\u9662\u4e8c\u533a93\u5206\uff01\u52a9\u529b\u4e2d\u533b\u836f\u521b\u9020\u65b0\u8f89\u714c\uff01\/8_27g6fAYLeH6Wwmiaa2tut47WVj5X1A.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6q2QVQ4SJ12mNjryuyTyeGVOTv7kQ4DnGSzfbsVm0hfdlJA27g6fAYLeH6Wwmiaa2tut47WVj5X1A\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"724\" style=\"width: 434px;height: 554px;\"><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\">Spp1\u662fKBA-Z-GS\u534f\u540c\u4fdd\u62a4MCAO\u7684\u67a2\u7ebd\u9776\u70b9<\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u57fa\u4e8e\u56fe4J\u3001\u56fe8J\u3001\u56fe5 G\u30019 G\u7684\u5171\u6709\u57fa\u56e0\u7684\u57fa\u7840\u4e0a\uff0c\u9274\u5b9a\u51fa9\u4e2a\u4e0eKBA+Z-GS\u534f\u540c\u4f5c\u7528\u76f8\u5173\u7684\u5171\u6709\u57fa\u56e0\u3002\u6700\u540e\uff0c\u7b5b\u9009\u51faKBA+Z-GS\u534f\u540c\u4fdd\u62a4MCAO\u76843\u4e2a\u57fa\u56e0\uff0c\u5305\u62ecSpp1\u3001Mt2\u548cMt1(\u56fe11A)\u3002Spp1\u5728\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548c\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e2d\u7684\u8868\u8fbe\u5206\u5e03\u5982\u56fe11B\u6240\u793a\u3002\u514d\u75ab\u8367\u5149\u67d3\u8272\u5206\u6790\u663e\u793a\u6a21\u578b\u7ec4Spp1\u8868\u8fbe\u4e0b\u964d\u3002\u7136\u800c\uff0c\u7ecfKBA\u6216Z-GS\u5904\u7406\u540e\uff0c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548c\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e2dSpp1\u6c34\u5e73\u5747\u663e\u8457\u5347\u9ad8\uff0cKBA\u548cZ-GS\u7684\u7ed3\u5408\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u4e86Spp1\u7684\u8868\u8fbe\uff0c\u4f7f\u5176\u8868\u8fbe\u6c34\u5e73\u4e0e\u5bf9\u7167\u7ec4\u51e0\u4e4e\u76f8\u5f53(\u56fe11C)\u3002\u5171\u57f9\u517b\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684\u7ed3\u679c\u4e5f\u8bc1\u5b9e\u4e86KBA\u548cZ-GS\u5bf9Spp1\u7684\u534f\u540c\u8c03\u8282\u4f5c\u7528(\u56fe11D)\u3002<\/span>    <o:page><\/o:page><\/p>\n<p style=\"text-align: justify;text-indent: 0pt;margin-bottom: 24px;\"><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"434\" data-cropsely1=\"0\" data-cropsely2=\"340\" data-imgfileid=\"100017999\" data-ratio=\"1.2761506276150627\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-26_\u300c\u8f6c\u300dBuff\u53e0\u6ee1\u4e86\uff01\u4e2d\u533b\u836f+\u5355\u7ec6\u80de+\u94c1\u6b7b\u4ea1+\u975e\u80bf\u7624\u75be\u75c5\uff01\uff01\u7b2c\u56db\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u4e01\u4e00\u56e2\u961f\u4e2d\u79d1\u9662\u4e8c\u533a93\u5206\uff01\u52a9\u529b\u4e2d\u533b\u836f\u521b\u9020\u65b0\u8f89\u714c\uff01\/9_mmTjeT5iafRXhgg4INuqoxIg41SNOQ.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/mmbiz_png\/vdJbOia6pHx6q2QVQ4SJ12mNjryuyTyeGLTQEYKibGm9JtvqHcfibGQv1AM0mmTjeT5iafRXhgg4INuqoxIg41SNOQ\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"717\" style=\"width: 434px;height: 554px;\"><\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;\"><\/span><\/p>\n<p style=\"text-indent: 0pt;text-align: center;margin-bottom: 24px;\"><span style=\"font-family: \u5b8b\u4f53;font-variant: normal;text-transform: none;font-weight: bold;color: rgb(0, 82, 255);\">\u6587\u7ae0\u5c0f\u7ed3<\/span><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;mso-bidi-font-weight:bold;\"><\/span><\/p>\n<p style=\"margin-top: 8.15pt;text-indent: 0pt;line-height: 200%;text-align: justify;margin-bottom: 24px;\"><span style=\"font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;\">\u8fd9\u7bc7\u6587\u7ae0\u903b\u8f91\u6e05\u6670\uff0c\u5c42\u5c42\u9012\u8fdb\uff0c\u901a\u8fc7scRNA-seq\u8bc1\u5b9e\u4e86KBA+Z-GS\u5728\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u7684\u534f\u540c\u4f5c\u7528\u53ca\u5176\u673a\u5236\u3002KBA+Z-GS\u534f\u540c\u8c03\u8282\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u53ca\u5176\u4e9a\u578b\u4e2d\u4e0d\u540c\u57fa\u56e0\u7684\u8868\u8fbe\u548c\u529f\u80fd\u3002\u521b\u65b0\u7684\u836f\u7269-\u57fa\u56e0\u534f\u540c\u8c03\u63a7\u6a21\u5f0f\u5e2e\u52a9\u7b5b\u9009\u4e86KBA\u548cZGS\u7684\u591a\u4e2a\u9776\u57fa\u56e0\uff0c\u5176\u4e2dSpp1\u88ab\u786e\u5b9a\u4e3a\u67a2\u7ebd\u57fa\u56e0\u3002\u901a\u8fc7\u7cbe\u786e\u7684\u836f\u7269\u5f00\u53d1\u9776\u5411Spp1\u53ef\u80fd\u4e3a\u7f3a\u8840\u6027\u5352\u4e2d\u63d0\u4f9b\u6709\u5e0c\u671b\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/span><span style=\"mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;\">\u8fd9\u7bc7\u6587\u7ae0\u5229\u7528\u7ec4\u5b66\u52a9\u653b\u4e2d\u533b\u836f\u5b9e\u9a8c\u7814\u7a76\uff0c\u4e30\u5bcc\u5b9e\u9a8c\u5185\u5bb9\uff0c\u7f29\u77ed\u7814\u7a76\u5468\u671f\uff0c\u5c06\u4e2d\u836f\u6cbb\u7597\u4f5c\u7528\u548c<\/span><span style=\"font-family:Times New Roman;mso-ascii-font-family:Times New Roman;mso-fareast-font-family:\u5b8b\u4f53;font-variant:normal;text-transform:none;font-weight:bold;\">scRNA-seq<\/span><span style=\"mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;font-weight:bold;\">\u5206\u6790\u8fdb\u884c\u4e86\u5b8c\u7f8e\u5730\u6709\u673a\u7ed3\u5408\uff0c\u5206\u6790\u5e76\u4e0d\u590d\u6742\uff0c\u5b9e\u9a8c\u96be\u5ea6\u4e5f\u4e0d\u9ad8\uff0c\u4f46\u4e24\u8005\u7ed3\u5408\u7684\u6548\u679c\u5f88\u4e0d\u9519\uff0c\u9986\u957f\u771f\u8bda\u5efa\u8bae\u5927\u5bb6\u8d76\u7d27\u6284\u4f5c\u4e1a\uff0c\u6362\u4e2a\u4e2d\u836f\u548c\u75be\u75c5\u4e0b\u4e00\u7bc7\u53d1\u8868\u9ad8\u5206\u7ec4\u5b66\u5206\u6790\u6587\u7ae0\u7684\u5c31\u662f\u4f60\uff01<\/span><span style=\"mso-bidi-font-size:14.0pt;font-family:\u5b8b\u4f53;mso-ascii-font-family:Times New Roman;font-variant:normal;text-transform:none;color:#FF0000;font-weight:bold;\">\u521b\u65b0\u601d\u8def\uff0c\u590d\u73b0\u7684\u5927\u597d\u65f6\u673a\uff0c\u9986\u957f\u5750\u7b49\u4f60\u7684\u8054\u7cfb\u54e6~<\/span><\/p>\n<p style=\"text-indent: 0px;margin-bottom: 0px;\"><span style=\"color: rgb(0, 122, 170);\"><strong><span style=\"color: rgb(0, 122, 170);letter-spacing: 0.578px;text-indent: 32px;text-wrap: wrap;background-color: rgb(255, 255, 255);font-size: 15px;\">\u5c0f\u679c\u8fd8<span style=\"color: rgb(0, 122, 170);background-color: rgb(255, 255, 255);font-size: 15px;letter-spacing: 0.578px;text-decoration: none solid rgba(0, 0, 0, 0.9);\">\u63d0\u4f9b\u601d\u8def\u8bbe\u8ba1\u3001\u5b9a\u5236\u751f\u4fe1\u5206\u6790\u3001\u6587\u732e\u601d\u8def\u590d\u73b0\uff1b\u6709\u9700\u8981\u7684\u5c0f\u4f19\u4f34\u6b22\u8fce\u76f4\u63a5\u626b\u7801\u54a8\u8be2\u5c0f\u679c\uff0c\u7aed\u8bda\u4e3a\u60a8\u7684\u79d1\u7814\u52a9\u529b\uff01<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 0px;\"><br \/><\/p>\n<section style=\"font-size: 15px;padding-right: 2px;padding-left: 2px;margin-bottom: 0px;\">\n<section style=\"text-align: center;justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;flex: 0 0 auto;height: auto;border-color: rgb(114, 114, 114);border-width: 1px;border-style: solid;box-shadow: rgb(194, 209, 255) -5px 5px 0px;align-self: flex-start;\">\n<section style=\"justify-content: center;display: flex;flex-flow: row;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 42.6829%;vertical-align: middle;box-shadow: rgb(43, 65, 110) 0px 0px 0px;flex: 0 0 auto;height: auto;padding-left: 10px;align-self: center;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;line-height: 0;transform: translate3d(20px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;width: 75%;height: auto;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018000\" data-ratio=\"1\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-26_\u300c\u8f6c\u300dBuff\u53e0\u6ee1\u4e86\uff01\u4e2d\u533b\u836f+\u5355\u7ec6\u80de+\u94c1\u6b7b\u4ea1+\u975e\u80bf\u7624\u75be\u75c5\uff01\uff01\u7b2c\u56db\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u4e01\u4e00\u56e2\u961f\u4e2d\u79d1\u9662\u4e8c\u533a93\u5206\uff01\u52a9\u529b\u4e2d\u533b\u836f\u521b\u9020\u65b0\u8f89\u714c\uff01\/10_B2jkicacLzPjw4xMSqVvoucZjonVDA.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHohxPNEVs2VFhPMukpU8lchxrvcB2jkicacLzPjw4xMSqVvoucZjonVDA\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"430\" style=\"vertical-align: middle;width: 100%;\" \/><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: 56.9106%;flex: 0 0 auto;height: auto;align-self: center;\">\n<section style=\"line-height: 2;letter-spacing: 1px;color: rgb(43, 65, 110);\" powered-by=\"xiumi.us\">\n<p style=\"margin-bottom: 2px;\"><strong>\u5b9a\u5236\u751f\u4fe1\u5206\u6790<\/strong><\/p>\n<p style=\"margin-bottom: 2px;\"><strong>\u670d\u52a1\u5668\u79df\u8d41<\/strong><\/p>\n<p><strong>\u626b\u7801\u54a8\u8be2\u5c0f\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p powered-by=\"xiumi.us\"><br \/><\/p>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener\"><span class=\"js_jump_icon h5_image_link\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100018002\" data-ratio=\"0.3253333333333333\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-26_\u300c\u8f6c\u300dBuff\u53e0\u6ee1\u4e86\uff01\u4e2d\u533b\u836f+\u5355\u7ec6\u80de+\u94c1\u6b7b\u4ea1+\u975e\u80bf\u7624\u75be\u75c5\uff01\uff01\u7b2c\u56db\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u4e01\u4e00\u56e2\u961f\u4e2d\u79d1\u9662\u4e8c\u533a93\u5206\uff01\u52a9\u529b\u4e2d\u533b\u836f\u521b\u9020\u65b0\u8f89\u714c\uff01\/11_7TvAyUibd1TPhJmZfialJtv6tu2SEg.png\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAxVYfSsM0wdf9d3RpNiaTcHoj9xlsoyiaBvzaezDUFAicibMAF8ts7TvAyUibd1TPhJmZfialJtv6tu2SEg\/640?wx_fmt=png&from=appmsg'\" data-type=\"png\" data-w=\"750\" style=\"vertical-align: middle;width: 100%;\"><\/span><\/a><\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_insertlocalimg\" data-imgfileid=\"100018001\" data-ratio=\"0.3811111111111111\" data-s=\"300,640\" src=\"\u56fe\u7247\/\u751f\u4fe1\u679c_2024-04-26_\u300c\u8f6c\u300dBuff\u53e0\u6ee1\u4e86\uff01\u4e2d\u533b\u836f+\u5355\u7ec6\u80de+\u94c1\u6b7b\u4ea1+\u975e\u80bf\u7624\u75be\u75c5\uff01\uff01\u7b2c\u56db\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u4e01\u4e00\u56e2\u961f\u4e2d\u79d1\u9662\u4e8c\u533a93\u5206\uff01\u52a9\u529b\u4e2d\u533b\u836f\u521b\u9020\u65b0\u8f89\u714c\uff01\/12_9N02aBaau07RufXeXRLmvAHsrFZxtw.jpg\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAz5wg6Ne6sYkannSE9NiatkcPh3icbKanJagacjU6LqJrGAL29N02aBaau07RufXeXRLmvAHsrFZxtw\/640?wx_fmt=jpeg&from=appmsg'\" data-type=\"jpeg\" data-w=\"900\" style=\"letter-spacing: 0.578px;text-align: center;text-wrap: wrap;\"><\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 10%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 2px;padding-left: 2px;\">\n<section style=\"margin: 10px 0% 2px;transform: translate3d(2px, 0px, 0px);\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 16px;color: rgb(58, 66, 94);line-height: 1;letter-spacing: 5px;text-align: center;\">\n<p><strong>\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgb(58, 66, 94);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;flex: 100 100 0%;align-self: flex-end;height: auto;\">\n<section style=\"margin-right: 0%;margin-left: 0%;\" powered-by=\"xiumi.us\">\n<section style=\"height: 3px;background-color: rgb(95, 156, 239);\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"margin-top: 2px;margin-right: 0%;margin-left: 0%;text-align: center;line-height: 0.8;font-size: 9px;\" powered-by=\"xiumi.us\">\n<section style=\"width: 0px;display: inline-block;border-top: 0.8em solid rgba(255, 255, 255, 0);border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"min-height: 40px;margin: 10px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"width: 100%;margin-right: auto;margin-bottom: -10px;margin-left: auto;\">\n<table width=\"100%\">\n<tbody>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:0\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:0.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;box-shadow: rgb(0, 0, 0) 0px 0px 0px;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>01<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247497780&idx=2&sn=7eee90af6f387e4153bba13028e545a1&chksm=cf7f68f1f808e1e7dfb3a0597ef442e5c6e700ecf6ee5a035c766a4c7486c12eabd0ab218ea6&scene=21#wechat_redirect\" textvalue=\"1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff0c\u4e24\u4eba\u6210\u56e2\uff0c1\u4eba\u514d\u5355\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:1\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:1.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>02<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498878&idx=1&sn=fc34ed3f1d15d060bbaf8166adcebd58&chksm=cf7f6cbbf808e5ad0b5417e50ed75cfbd1b3a83ac43b97f1dfa718c822878a9a004990075133&scene=21#wechat_redirect\" textvalue=\"\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5355\u4e2a\u6570\u636e\u5e93\u7528\u817b\u4e86\uff1f\u591a\u6570\u636e\u5e93\u201c\u7ec4\u5408\u62f3\u201d\u5e26\u4f60\u6253\u5f00\u514d\u75ab\u6d78\u6da6\u65b0\u601d\u8def\uff01<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:2\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:2.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>03<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498673&idx=1&sn=1e09b74a836c1e64a62ae1f66eeb3f93&chksm=cf7f6b74f808e262de70be43fd73bf5fefdc0914e525eb2032f741a0152e619689cedc76946f&scene=21#wechat_redirect\" textvalue=\"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7684\u51c6\u5907\u5de5\u4f5c\uff0cGWAS\u6570\u636e\u7684\u7f51\u7ad9\u4e0b\u8f7d\u65b9\u6cd5<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 5px 0%;\" powered-by=\"xiumi.us\">\n<section style=\"background-color: rgb(224, 224, 224);height: 1px;\"><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<tr opera-tn-ra-comp=\"_$.pages:0.layers:0.comps:4.classicTable1:3\" powered-by=\"xiumi.us\">\n<td colspan=\"1\" rowspan=\"1\" opera-tn-ra-cell=\"_$.pages:0.layers:0.comps:4.classicTable1:3.td@@0\" style=\"border-color: rgb(62, 62, 62);border-style: none;padding: 0px;\" width=\"100.0000%\">\n<section>\n<section style=\"display: flex;flex-flow: row;margin-top: 10px;margin-right: 0%;margin-left: 0%;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: auto;min-width: 10%;height: auto;flex: 0 0 auto;align-self: center;\">\n<section style=\"font-size: 19px;color: rgb(95, 156, 239);line-height: 1;\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><strong>04<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;align-self: center;height: auto;\">\n<section style=\"color: rgb(140, 140, 140);\" powered-by=\"xiumi.us\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(224, 224, 224);\">\uff5c<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247498517&idx=1&sn=fa3c0104cee316982fe8162b79fe234f&chksm=cf7f6bd0f808e2c6cf979704bf883cfb5480444604f90da61dc286e7541fa5bb49df0a2fb58a&scene=21#wechat_redirect\" textvalue=\"\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature \u7ea7\u522b\u7684\u4e3b\u6210\u5206\u5206\u6790\uff08PCA\uff09\u56fe\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u8ddf\u7740\u5c0f\u679c\u5b66\u590d\u73b0-\u624b\u628a\u624b\u5e26\u4f60\u62ff\u4e0bIF=46.9Nature 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\/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Buff\u53e0\u6ee1\u4e86\uff01\u4e2d\u533b\u836f+\u5355\u7ec6\u80de+\u94c1\u6b7b\u4ea1+\u975e\u80bf\u7624\u75be\u75c5\uff01\uff01\u7b2c\u56db\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u4e01\u4e00\u56e2\u961f\u4e2d\u79d1\u9662\u4e8c\u533a9.3\u5206\uff01\u52a9\u529b\u4e2d\u533b […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/60006"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=60006"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/60006\/revisions"}],"predecessor-version":[{"id":60008,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/60006\/revisions\/60008"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=60006"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=60006"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=60006"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}