{"id":60450,"date":"2024-06-17T11:24:51","date_gmt":"2024-06-17T03:24:51","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=60450"},"modified":"2024-06-17T11:24:51","modified_gmt":"2024-06-17T03:24:51","slug":"%e6%89%8b%e6%8a%8a%e6%89%8b%e7%9a%84%e6%95%99%e7%a8%8b%ef%bc%81%e4%b8%80%e6%96%87%e5%b0%8f%e6%9e%9c%e6%95%99%e4%bd%a0%e5%ad%a6%e4%bc%9a%e4%b8%b4%e5%ba%8a%e5%86%b3%e7%ad%96%e6%9b%b2%e7%ba%bf%ef%bc%88-3","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=60450","title":{"rendered":"\u624b\u628a\u624b\u7684\u6559\u7a0b\uff01\u4e00\u6587\u5c0f\u679c\u6559\u4f60\u5b66\u4f1a\u4e34\u5e8a\u51b3\u7b56\u66f2\u7ebf\uff08DCA\uff09\uff01\uff01"},"content":{"rendered":"


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onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_jpg\/zcicibWZessAysHY49vPGCraibakiaNq6hQgn8C5MfvVLQGxlNZPEia2PajKAzrE2v0O5WiaUDJjgv5bxK2G1ePHyH2g\/640?wx_fmt=jpeg'\" data-type=\"jpeg\" data-w=\"1080\" style=\"letter-spacing: 0.578px;text-align: center;text-wrap: wrap;\" data-recalc-dims=\"1\" 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style=\"text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.38981481481481484\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/2_IWicymEetCc6Enf2BkUE4Yz1Ya5e5w-33.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAyuYsqlJnQUJvnS2iciaDibtfbdV0VmHlriaSjYwjFPLp1BLjokHIWicymEetCc6Enf2BkUE4Yz1Ya5e5w\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"letter-spacing: 0.578px;text-wrap: wrap;text-align: center;\" data-imgfileid=\"100012153\" data-recalc-dims=\"1\" \/><\/p>\n<p><span style=\"font-size: 14px;\"><strong>\u51b3\u7b56\u66f2\u7ebf\u5206\u6790\u6cd5\uff08decision curve analysis\uff0cDCA\uff09\u662f\u4e00\u79cd\u8bc4\u4f30\u4e34\u5e8a\u9884\u6d4b\u6a21\u578b\u3001\u8bca\u65ad\u8bd5\u9a8c\u548c\u5206\u5b50\u6807\u8bb0\u7269\u7684\u7b80\u5355\u65b9\u6cd5\u3002<\/strong> 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normal;color: rgb(178, 178, 178);\"><span style=\"font-family: "Helvetica Neue", Helvetica, "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif;font-size: 14px;letter-spacing: 0.476px;text-decoration: underline;\">\u516c\u4f17\u53f7\u540e\u53f0\u56de\u590d\u201c111\u201d\u9886\u53d6\u4ee3\u7801\uff0c\u4ee3\u7801\u7f16\u53f7\uff1a231010<\/span><\/em><\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u5c0f\u679c\u8fd9\u91cc\u4f7f\u7528\u7684\u662fR\u5305rmda\u5305\u53bb\u7ed8\u5236DCA\uff0c\u5176\u5b9e\u8fd8\u6709\u5f88\u591a\u5305\u6bd4\u5982ggDCA\u7b49\uff0c<\/span><\/p>\n<section data-mpa-template=\"t\" mpa-from-tpl=\"t\">\n<section data-mpa-template=\"t\" mpa-from-tpl=\"t\">\n<section style=\"text-align: justify;font-size: 16px;\" mpa-from-tpl=\"t\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;border-style: solid;border-width: 0px 0px 7px;border-bottom-color: rgb(175, 225, 255);min-width: 5%;height: auto;\" mpa-from-tpl=\"t\">\n<section style=\"text-align: justify;font-size: 20px;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<p><strong mpa-from-tpl=\"t\" mpa-is-content=\"t\">\u6211\u4eec\u5148\u5bfc\u5165\u6570\u636e\uff1a<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 5%;flex: 0 0 auto;height: auto;align-self: flex-end;\" mpa-from-tpl=\"t\">\n<section style=\"transform: perspective(0px);transform-style: flat;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<section style=\"transform: translate3d(5px, 0px, 0px) rotateX(180deg);\" mpa-from-tpl=\"t\">\n<section style=\"display: inline-block;width: 6px;height: 6px;vertical-align: top;overflow: hidden;border-radius: 460px;background-color: rgb(244, 171, 189);\" mpa-from-tpl=\"t\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<p><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"xml\"><code><span class=\"code-snippet_outer\">dcaData <- read.table(\"test2.txt\",sep = \"t\",row.names = 1,check.names = F,stringsAsFactors = F,header = T)<\/span><\/code><\/pre>\n<\/section>\n<p><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.3432377049180328\" data-type=\"png\" data-w=\"976\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/3_IQLzkHt2HL4U8yoqvpgpG78csHicRA.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpwgJjcnfZ26ZY9wtrgmlgnpFJ2IQLzkHt2HL4U8yoqvpgpG78csHicRA\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/p>\n<p><span style=\"font-size: 14px;\">\u5c0f\u679c\u8fd9\u91cc\u4f7f\u7528\u7684\u662f\u5c0f\u679c\u5e73\u65f6\u6574\u7406\u7684\uff0c\u5c0f\u4f19\u4f34\u53ef\u4ee5\u6309\u7167\u81ea\u5df1\u6570\u636e\u5f62\u5f0f\u53bb\u8bbe\u7f6e\uff0c\u5c0f\u679c\u63d0\u9192\u4e00\u4e0b\uff0c\u6570\u636e\u5f62\u5f0f\u8981\u8bbe\u7f6e\u6210\u6570\u5b57\u7684\u5f62\u5f0f\uff0c\u8fd9\u91cc\u5c0f\u679c\u7684\u4e34\u5e8a\u7279\u5f81\u5728\u56fe\u4e2d\uff0c\u4e5f\u52a0\u5165\u4e86\u4e00\u4e9b\u57fa\u56e0\u653e\u5165\u6a21\u578b\u4e2d<\/span><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"shell\"><code><span class=\"code-snippet_outer\">library(rmda)#\u52a0\u8f7d\u5305<\/span><\/code><code><span class=\"code-snippet_outer\">#data(\"dcaData\")<\/span><\/code><\/pre>\n<\/section>\n<section data-mpa-template=\"t\" mpa-from-tpl=\"t\">\n<section data-mpa-template=\"t\" mpa-from-tpl=\"t\">\n<section style=\"text-align: justify;font-size: 16px;\" mpa-from-tpl=\"t\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;border-style: solid;border-width: 0px 0px 7px;border-bottom-color: rgb(175, 225, 255);min-width: 5%;height: auto;\" mpa-from-tpl=\"t\">\n<section style=\"text-align: justify;font-size: 20px;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<p><strong mpa-from-tpl=\"t\" mpa-is-content=\"t\">#\u6784\u67b6\u57fa\u7840DCA\u6a21\u578b<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 5%;flex: 0 0 auto;height: auto;align-self: flex-end;\" mpa-from-tpl=\"t\">\n<section style=\"transform: perspective(0px);transform-style: flat;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<section style=\"transform: translate3d(5px, 0px, 0px) rotateX(180deg);\" mpa-from-tpl=\"t\">\n<section style=\"display: inline-block;width: 6px;height: 6px;vertical-align: top;overflow: hidden;border-radius: 460px;background-color: rgb(244, 171, 189);\" mpa-from-tpl=\"t\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<p><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"makefile\"><code><span class=\"code-snippet_outer\">model <- decision_curve(event~stage + age + Mstage + Nstage + Grade+PCNA+MCM2+GINS2+time ,<\/span><\/code><code><span class=\"code-snippet_outer\">family=binomial(link='logit'),<\/span><\/code><code><span class=\"code-snippet_outer\">data = dcaData,<\/span><\/code><code><span class=\"code-snippet_outer\">thresholds = seq(0, .4, by = .005),<\/span><\/code><code><span class=\"code-snippet_outer\">bootstraps = 10)<\/span><\/code><\/pre>\n<\/section>\n<p><span style=\"font-size: 14px;\">\u5728\u4e0a\u8ff0decision_curve()\u51fd\u6570\u4e2d\uff0c family=binomial\uff08link=\u2018logit\uff09\u662f\u4f7f\u7528Logistic\u56de\u5f52\u6765\u62df\u5408\u6a21\u578b\uff0c\u9ed8\u8ba4\u503c\u3002threshold\u8bbe\u7f6e\u6a2a\u5750\u6807\u9608\u6982\u7387\u7684\u8303\u56f4\uff0c\u4e00\u822c\u662f0~1\u3002\u4f46\u5982\u679c\u6709\u67d0\u79cd\u5177\u4f53\u60c5\u51b5\uff0c\u5927\u5bb6\u4e00\u81f4\u8ba4\u4e3a\u9608\u6982\u7387\u8fbe\u5230\u67d0\u4e2a\u503c\u4ee5\u4e0a\uff0c\u6bd4\u598250%\uff0c\u5219\u5fc5\u987b\u91c7\u53d6\u5e72\u9884\u63aa\u65bd\uff0c\u90a3\u4e480.5\u4ee5\u4e0a\u7684\u7814\u7a76\u5c31\u6ca1\u4ec0\u4e48\u610f\u4e49\u4e86\uff0c\u53ef\u4ee5\u8bbe\u4e3a0-0.5\u3002by\u662f\u6307\u6bcf\u9694\u591a\u5c11\u8ddd\u79bb\u8ba1\u7b97\u4e00\u4e2a\u6570\u636e\u70b9\u3002bootsrap \u91cd\u62bd\u6837\u6b21\u6570<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u5c0f\u679c\u8fd9\u91cc\u662f\u6309\u7167\u81ea\u5df1\u7684\u4e34\u5e8a\u7279\u5f81\u8fd8\u6709\u57fa\u56e0\uff0c\u5c0f\u4f19\u4f34\u8981\u6309\u7167\u81ea\u5df1\u60c5\u51b5\u6765<\/span><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"apache\"><code><span class=\"code-snippet_outer\">#event~stage + age + Mstage + Nstage + Grade+PCNA+MCM2+GINS2+time<\/span><\/code><\/pre>\n<\/section>\n<p><span style=\"font-size: 14px;\">\u4e0b\u9762\u5c31\u662f\u7ed8\u5236DCA\u7684\u57fa\u672c\u56fe\u5f62\u4e86\u6211\u4eec\u4f7f\u7528\u9ed8\u8ba4\u7684\u53c2\u6570<\/span><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"makefile\"><code><span class=\"code-snippet_outer\">plot_decision_curve(model,<\/span><\/code><code><span class=\"code-snippet_outer\">curve.names = \"Clinical and genetic models\",<\/span><\/code><code><span class=\"code-snippet_outer\">col = c(\"#DC0000B2\"),<\/span><\/code><code><span class=\"code-snippet_outer\">confidence.intervals=F #\u4e0d\u663e\u793a\u7f6e\u4fe1\u533a\u95f4<\/span><\/code><code><span class=\"code-snippet_outer\">)<\/span><\/code><\/pre>\n<\/section>\n<p><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.0153374233128833\" data-type=\"png\" data-w=\"652\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/4_SZFRogMvMUZKAVF5RPnOqq1P8gGS5w-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpub9Hh6fBSFP8fpIQwulibDibbWSZFRogMvMUZKAVF5RPnOqq1P8gGS5w\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/p>\n<p><span style=\"font-size: 14px;\">\u989c\u8272\u540d\u79f0\u90fd\u53ef\u4ee5\u81ea\u5df1\u8c03\u6574<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u4f46\u662f\u6709\u7684\u5c0f\u4f19\u4f34\u60f3\u5bf9\u6bd4\u4e24\u4e2a\u6a21\u578b\uff0c\u603b\u4e0d\u80fd\u7ed8\u5236\u4e24\u4e2a\u56fe\u5427\uff0c\u5c0f\u679c\u4e0b\u9762\u5c31\u6559\u5927\u5bb6\u7ed8\u5236\u4e24\u4e2a\u6a21\u578b\u7684DCA\u66f2\u7ebf<\/span><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"makefile\"><code><span class=\"code-snippet_outer\">model.Clinic <- decision_curve(event~stage + age + Mstage + Nstage + Grade,<\/span><\/code><code><span class=\"code-snippet_outer\">data = dcaData,<\/span><\/code><code><span class=\"code-snippet_outer\">thresholds = seq(0, .4,by = .005),<\/span><\/code><code><span class=\"code-snippet_outer\">bootstraps = 10)# stage + age + Mstage + Nstage + Grade\u53d8\u91cf\u5efa\u7acb\u6a21\u578b<\/span><\/code><\/pre>\n<\/section>\n<p><span style=\"font-size: 14px;\">\u6211\u4eec\u5148\u5728\u6784\u5efa\u4e00\u4e2a\u6a21\u578b\uff0c\u8fd9\u6211\u4eec\u968f\u4fbf\u4f7f\u7528\u51e0\u4e2a\u53d8\u91cf\u8fdb\u884c\u5c55\u793a\uff0c\u5c0f\u4f19\u4f34\u8981\u6309\u7167\u81ea\u5df1\u7684\u53d8\u91cf\u53bb\u8bbe\u7f6e<\/span><\/p>\n<section data-mpa-template=\"t\" mpa-from-tpl=\"t\">\n<section data-mpa-template=\"t\" mpa-from-tpl=\"t\">\n<section style=\"text-align: justify;font-size: 16px;\" mpa-from-tpl=\"t\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;border-style: solid;border-width: 0px 0px 7px;border-bottom-color: rgb(175, 225, 255);min-width: 5%;height: auto;\" mpa-from-tpl=\"t\">\n<section style=\"text-align: justify;font-size: 20px;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<p><strong mpa-from-tpl=\"t\" mpa-is-content=\"t\">#\u7ed8\u5236\u4e24\u4e2a\u6a21\u578bDCA\u66f2\u7ebf<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 5%;flex: 0 0 auto;height: auto;align-self: flex-end;\" mpa-from-tpl=\"t\">\n<section style=\"transform: perspective(0px);transform-style: flat;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<section style=\"transform: translate3d(5px, 0px, 0px) rotateX(180deg);\" mpa-from-tpl=\"t\">\n<section style=\"display: inline-block;width: 6px;height: 6px;vertical-align: top;overflow: hidden;border-radius: 460px;background-color: rgb(244, 171, 189);\" mpa-from-tpl=\"t\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<p><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"makefile\"><code><span class=\"code-snippet_outer\">plot_decision_curve(list(model, model.Clinic),<\/span><\/code><code><span class=\"code-snippet_outer\">curve.names = c(\"Hub Gene model\", \"Clinic model\"),<\/span><\/code><code><span class=\"code-snippet_outer\">col = c(\"#3C5488B2\", \"#DC0000B2\"),#\u8bbe\u7f6e\u7ebf\u7684\u989c\u8272<\/span><\/code><code><span class=\"code-snippet_outer\">lty = c(1,2), # \u8bbe\u7f6e\u7ebf\u5f62<\/span><\/code><code><span class=\"code-snippet_outer\">lwd = c(3,3, 2, 2), #\u8bbe\u7f6e\u7ebf\u5bbd\uff0c\u5206\u522b\u4e3abaseling.model\u3001full.model\u3001All\u548cNone<\/span><\/code><code><span class=\"code-snippet_outer\">confidence.intervals = F,<\/span><\/code><code><span class=\"code-snippet_outer\">legend.position = \"topright\")<\/span><\/code><\/pre>\n<\/section>\n<p><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.0642633228840126\" data-type=\"png\" data-w=\"638\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/5_bYyTSolg49dictNcIBcQWQZgeaO7uA-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpiaQCYR3Kible9RQPOuicn8lNenOKibYyTSolg49dictNcIBcQWQZgeaO7uA\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/p>\n<p><span style=\"font-size: 14px;\">DCA\u66f2\u7ebf\u4e0d\u6b62\u53ef\u4ee5\u6784\u5efa\u6a21\u578b\u7684\u9a8c\u8bc1\uff0c\u8fd8\u53ef\u4ee5\u7ed8\u5236\u4e34\u5e8a\u7684\u5f71\u54cd\u66f2\u7ebf\uff1a<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u8fd9\u91cc\u6211\u4eec\u4f7f\u7528plot_clinical_impact()\u51fd\u6570\u7ed8\u5236baseline.model\u6a21\u578b\u7684\u4e34\u5e8a\u5f71\u54cd\u66f2\u7ebf\uff08clinical impact curve\uff09\u3002\u6a21\u578b\u9884\u6d4b1 000\u4eba\u7684\u98ce\u9669\u5206\u5c42\uff0c\u663e\u793a\u201c\u635f\u5931:\u53d7\u76ca\u201d\u5750\u6807\u8f74\uff0c\u663e\u793a\u7f6e\u4fe1\u533a\u95f4\u3002<\/span><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"makefile\"><code><span class=\"code-snippet_outer\">plot_clinical_impact(model,<\/span><\/code><code><span class=\"code-snippet_outer\">xlim = c(0, .4),<\/span><\/code><code><span class=\"code-snippet_outer\">col = c(\"#3C5488B2\", \"#DC0000B2\"))<\/span><\/code><\/pre>\n<\/section>\n<p><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.0217391304347827\" data-type=\"png\" data-w=\"644\" style=\"height: auto !important;\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/6_acDjlxSLeozxF6icRhqAaj4MP8zOMg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpqWfBjiblPZTOTVfbgPykbm6w6tiacDjlxSLeozxF6icRhqAaj4MP8zOMg\/640?wx_fmt=png'\" data-recalc-dims=\"1\" \/><\/p>\n<p><span style=\"font-size: 14px;\">\u5982\u679c\u5c0f\u4f19\u4f34\u89c9\u5f97\u4e24\u4e2a\u6a21\u578b\u7684\u8ba1\u7b97\u65b9\u5f0f\u4e00\u6837\uff0c\u6211\u4eec\u53ef\u4ee5\u4f7f\u7528\u4ea4\u53c9\u7684\u9a8c\u8bc1\u53bb\u7ed8\u5236DCA\u66f2\u7ebf<\/span><\/p>\n<section data-mpa-template=\"t\" mpa-from-tpl=\"t\">\n<section data-mpa-template=\"t\" mpa-from-tpl=\"t\">\n<section style=\"text-align: justify;font-size: 16px;\" mpa-from-tpl=\"t\">\n<section style=\"text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;border-style: solid;border-width: 0px 0px 7px;border-bottom-color: rgb(175, 225, 255);min-width: 5%;height: auto;\" mpa-from-tpl=\"t\">\n<section style=\"text-align: justify;font-size: 20px;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<p><strong mpa-from-tpl=\"t\" mpa-is-content=\"t\">#\u4ea4\u53c9\u9a8c\u8bc1<\/strong><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: bottom;width: auto;min-width: 5%;flex: 0 0 auto;height: auto;align-self: flex-end;\" mpa-from-tpl=\"t\">\n<section style=\"transform: perspective(0px);transform-style: flat;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<section style=\"transform: translate3d(5px, 0px, 0px) rotateX(180deg);\" mpa-from-tpl=\"t\">\n<section style=\"display: inline-block;width: 6px;height: 6px;vertical-align: top;overflow: hidden;border-radius: 460px;background-color: rgb(244, 171, 189);\" mpa-from-tpl=\"t\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\" mpa-from-tpl=\"t\">\n<p><br \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"perl\"><code><span class=\"code-snippet_outer\">full.model <- cv_decision_curve(event~stage + age + GINS2 + MCM2 + PCNA,<\/span><\/code><code><span class=\"code-snippet_outer\">data = dcaData,<\/span><\/code><code><span class=\"code-snippet_outer\">folds = 5,<\/span><\/code><code><span class=\"code-snippet_outer\">thresholds = seq(0, .4, by = .01))<\/span><\/code><code><span class=\"code-snippet_outer\">full.model_Hub <- decision_curve(event~stage + age + GINS2 + MCM2 + PCNA,<\/span><\/code><code><span class=\"code-snippet_outer\">data = dcaData,<\/span><\/code><code><span class=\"code-snippet_outer\">thresholds = seq(0, .4,by = .01),<\/span><\/code><code><span class=\"code-snippet_outer\">confidence.intervals = 'none')<\/span><\/code><\/pre>\n<\/section>\n<p><span style=\"font-size: 14px;\">\u540c\u6837\u7684\u6211\u4eec\u5148\u7ed8\u5236\u4e24\u4e2a\u6a21\u578b\uff0c\u8ba1\u7b97\u65b9\u5f0f\u6709\u6539\u53d8\uff0c\u4e00\u4e2a\u662fcv_decision_curve\uff0c\u4e00\u4e2a\u662fdecision_curve<\/span><\/p>\n<section class=\"code-snippet__fix code-snippet__js\">\n<ul class=\"code-snippet__line-index code-snippet__js\">\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<li><\/li>\n<\/ul>\n<pre class=\"code-snippet__js\" data-lang=\"makefile\"><code><span class=\"code-snippet_outer\">plot_decision_curve(list(full.model_Hub, full.model),<\/span><\/code><code><span class=\"code-snippet_outer\">curve.names = c('Apparent curve',<\/span><\/code><code><span class=\"code-snippet_outer\">'Cross-validated curve'),<\/span><\/code><code><span class=\"code-snippet_outer\">col = c(\"#3C5488B2\", \"#DC0000B2\"),<\/span><\/code><code><span class=\"code-snippet_outer\">lty = c(2,1),<\/span><\/code><code><span class=\"code-snippet_outer\">lwd = c(3,2, 2, 1),<\/span><\/code><code><span class=\"code-snippet_outer\">legend.position = (\"topright\"))<\/span><\/code><\/pre>\n<\/section>\n<p><span style=\"font-size: 14px;\">\u540c\u6837\u7684\u4ee3\u7801\u7ed8\u5236\u4e24\u4e2a\u66f2\u7ebf<\/span><\/p>\n<p><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.9730134932533733\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/7_MqC3NfDzD6JvRvzoHWgK34tDjGjrQg-1.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAzWmtjEBfHm54YFcU2iaKycpSpu2p3OyGXEuYs3Y4wf8rkgxMqC3NfDzD6JvRvzoHWgK34tDjGjrQg\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"667\" style=\"height: auto !important;\" data-recalc-dims=\"1\"><\/p>\n<p><span style=\"font-size: 14px;\">\u7ed3\u679c\u4e0d\u4e00\u6837\uff0c\u597d\u4e86\u4e0a\u8ff0\u4ee3\u7801\u6211\u4eec\u624b\u628a\u624b\u6559\u4f1a\u5927\u5bb6\u5982\u4f55\u7ed8\u5236DCA\u56fe\uff0c\u8fd8\u4e0d\u5feb\u53bb\u8bd5\u8bd5\uff1f<\/span><span style=\"font-size: var(--articleFontsize);letter-spacing: 0.034em;text-align: center;\"><\/span><strong style=\"font-size: 14px;letter-spacing: 0.034em;\">\u5c0f\u4f19\u4f34\u8981\u591a\u591a\u7406\u89e3\u4ee3\u7801\u7684\u610f\u4e49\uff0c\u4e5f\u8981\u7406\u89e3\u7ed8\u5236\u56fe\u7684\u542b\u4e49\uff0c\u8fd9\u6837\u624d\u80fd\u5c06\u7ed8\u5236\u7684\u56fe\u653e\u5165\u81ea\u5df1\u7684\u6587\u7ae0\u4e2d\uff01<\/strong><\/p>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;letter-spacing: 0.578px;text-wrap: wrap;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color: rgb(255, 255, 255);text-align: left;\">\n<section style=\"outline: 0px;font-size: 16px;\">\n<section powered-by=\"xiumi.us\" style=\"margin: 10px;outline: 0px;justify-content: flex-start;display: flex;flex-flow: row;\">\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;display: inline-block;width: 558px;vertical-align: top;border-style: dashed;border-width: 1px;border-color: rgb(62, 62, 62);align-self: flex-start;flex: 0 0 auto;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;\">\n<section style=\"outline: 0px;display: inline-block;width: 536px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(144, 215, 236);border-right-color: rgb(46, 172, 109);box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-bottom-left-radius: 0px;\">\n<section powered-by=\"xiumi.us\" style=\"padding-right: 3px;padding-left: 3px;outline: 0px;\">\n<section style=\"margin-top: 0.95em;margin-bottom: -0.65em;outline: 0px;display: inline-block;width: 520px;vertical-align: top;\">\n<section style=\"margin-top: -1em;padding: 3px 10px;outline: 0px;display: inline-block;vertical-align: top;color: rgb(0, 154, 68);\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;\">\u5f80\u671f\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;text-align: justify;\">\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491794&idx=1&sn=2b7a4de95169c79202e44813885a8250&chksm=cf7f7017f808f9015689839fe4057fd418bf7b20eb1dfb5a28cd92e56a41b5605e62bfbc16fb&scene=21#wechat_redirect\" textvalue=\"1.\u642d\u5efa\u751f\u4fe1\u5206\u6790\u6d41\u6c34\u7ebf\uff0c\u5982\u5de5\u5382\u4e00\u683724\u5c0f\u65f6\u8fd0\u8f6cSnakemake\u2014\u2014\u8fdb\u9636\u547d\u4ee4\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;font-size: 14px;\" rel=\"noopener\">1.\u642d\u5efa\u751f\u4fe1\u5206\u6790\u6d41\u6c34\u7ebf\uff0c\u5982\u5de5\u5382\u4e00\u683724\u5c0f\u65f6\u8fd0\u8f6cSnakemake\u2014\u2014\u8fdb\u9636\u547d\u4ee4<\/a><br style=\"outline: 0px;\" \/><\/section>\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491705&idx=1&sn=9ff9b6da28b3a256a99c6697d589be66&chksm=cf7f70bcf808f9aafd1019a0bba3dd3a55e2867dbb9a09203f13c2683adf867094637c405ed1&scene=21#wechat_redirect\" textvalue=\"2.\u6bd4blast\u8fd8\u4f18\u79c0\u7684\u5e8f\u5217\u6bd4\u5bf9\u5de5\u5177\uff1fHMMER\u6765\u4e86\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;font-size: 14px;\" rel=\"noopener\">2.\u6bd4blast\u8fd8\u4f18\u79c0\u7684\u5e8f\u5217\u6bd4\u5bf9\u5de5\u5177\uff1fHMMER\u6765\u4e86<\/a><\/section>\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491909&idx=1&sn=902e34bcf53e605fba2b457ec6a33e36&chksm=cf7f7180f808f8961542f458a49da14e85d8831449fb65fbf2623d55affc564686a5422f56fd&scene=21#wechat_redirect\" textvalue=\"3.\u5bf9\u5355\u7ec6\u80de\u5206\u6790\u6beb\u65e0\u5934\u7eea\uff1f\u8ba9popsicleR\u9886\u4f60\u5165\u95e8\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;font-size: 14px;\" rel=\"noopener\">3.\u5bf9\u5355\u7ec6\u80de\u5206\u6790\u6beb\u65e0\u5934\u7eea\uff1f\u8ba9popsicleR\u9886\u4f60\u5165\u95e8<\/a><\/section>\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247491905&idx=1&sn=fb34ebd6282962c7803badaee7a39096&chksm=cf7f7184f808f8929608c0050344ad86193d0fc6455c1c18e16cc17bf4b37832b63d3b18284e&scene=21#wechat_redirect\" textvalue=\"4.\u5c0f\u679c\u5e26\u4f60\u7ed8\u5236ROC\u66f2\u7ebf\u8bc4\u4f30\u751f\u5b58\u9884\u6d4b\u80fd\u529b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;\" rel=\"noopener\"><span style=\"outline: 0px;font-size: 14px;\">4.\u5c0f\u679c\u5e26\u4f60\u7ed8\u5236ROC\u66f2\u7ebf\u8bc4\u4f30\u751f\u5b58\u9884\u6d4b\u80fd\u529b<\/span><\/a><\/section>\n<section style=\"outline: 0px;letter-spacing: 0.578px;line-height: 1.75em;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=Mzg3OTg3MjQyNg==&mid=2247493633&idx=1&sn=2263dfe7572c0bcf6816c2c1a37d79de&chksm=cf7f78c4f808f1d2209321d6ace39fde5fa60c0691b56f88eac21916f5a2872ce8ee345f1d5f&scene=21#wechat_redirect\" textvalue=\"\u8f6f\u4ef6\u5305\u5b89\u88c5\u3001\u6253\u602a\u5feb\u53c8\u597d\uff0c1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff1b\u8fd8\u6709\u6bd4\u8fd9\u66f4\u7701\u94b1\u7684\u561b\uff01\uff01\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"color: var(--weui-LINK);outline: 0px;cursor: pointer;letter-spacing: 0.578px;font-size: 14px;\" rel=\"noopener\">5.\u8f6f\u4ef6\u5305\u5b89\u88c5\u3001\u6253\u602a\u5feb\u53c8\u597d\uff0c1024G\u5b58\u50a8\u7684\u751f\u4fe1\u670d\u52a1\u5668\uff1b\u8fd8\u6709\u6bd4\u8fd9\u66f4\u7701\u94b1\u7684\u561b\uff01\uff01\uff01<\/a><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 0pt;margin-bottom: 0pt;margin-left: 0pt;letter-spacing: 0.578px;text-indent: 0pt;text-wrap: wrap;text-align: left;line-height: normal;font-size: 12pt;font-family: helvetica;color: rgb(0, 0, 0);break-after: auto;\"><span style=\"font-family: \u5b8b\u4f53;font-size: 12pt;text-indent: 0pt;color: rgba(0, 0, 0, 0.9);letter-spacing: 0.034em;\"><\/span><span style=\"font-size: 15px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-imgfileid=\"100012155\" data-ratio=\"0.38981481481481484\" data-s=\"300,640\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/8_FbEg9fibwQicL8l2ExKOZZTmAHXabQ-17.png?w=640\" onerror=\"this.src='https:\/\/mmbiz.qpic.cn\/sz_mmbiz_png\/zcicibWZessAx3HetBkB7aOGibFWKqibqIATyC4zFibzCgdrxFwRep6cDMLIbA0FbEg9fibwQicL8l2ExKOZZTmAHXabQ\/640?wx_fmt=png'\" data-type=\"png\" data-w=\"1080\" style=\"font-size: var(--articleFontsize);letter-spacing: 0.034em;caret-color: rgba(0, 0, 0, 0);\" data-recalc-dims=\"1\" \/><\/span><\/p>\n<p style=\"display: none;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<p><\/content>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u624b\u628a\u624b\u7684\u6559\u7a0b\uff01\u4e00\u6587\u5c0f\u679c\u6559\u4f60\u5b66\u4f1a\u4e34\u5e8a\u51b3\u7b56\u66f2\u7ebf\uff08DCA\uff09\uff01\uff01 \u539f\u521b  \u5c0f\u679c &nbs […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/60450"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=60450"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/60450\/revisions"}],"predecessor-version":[{"id":60460,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/60450\/revisions\/60460"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=60450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=60450"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=60450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}