{"id":60640,"date":"2024-06-17T17:24:42","date_gmt":"2024-06-17T09:24:42","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=60640"},"modified":"2024-06-17T17:24:44","modified_gmt":"2024-06-17T09:24:44","slug":"%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96-%e5%a6%82%e4%bd%95%e9%80%89%e6%8b%a9%e5%b7%a5%e5%85%b7%e5%8f%98%e9%87%8f-4","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=60640","title":{"rendered":"\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u2014\u2014\u5982\u4f55\u9009\u62e9\u5de5\u5177\u53d8\u91cf"},"content":{"rendered":"<p>\u00a0<\/p>\n<p><strong>\u4e00\u3001\u8868\u578bGWAS\u7ed3\u679c\u4e2d\u5177\u6709\u663e\u8457\u5173\u8054\u7684SNP<\/strong><\/p>\n<p>\u6807\u51c6\u9608\u503c\u5c0f\u4e8e5e-8\u663e\u8457\u4f4d\u70b9\uff08\u6bd4\u5982SNP\u4f4d\u70b9\u6570\u5927\u4e8e20\u4e2a\uff09\uff0c\u53ef\u4ee5\u76f4\u63a5\u8fdb\u884c\u540e\u7eed\u7684\u7b5b\u9009<\/p>\n<p>\u5982\u679c\u9608\u503c\u5c0f\u4e8e5e-8\u663e\u8457\u4f4d\u70b9\u53ea\u6709\u4e2a\u4f4d\u6570\uff0c\u751a\u81f3\u4e3a0\uff0c\u90a3\u4e48\u53ef\u4ee5\u5c1d\u8bd51e-7\u30011e-6\u30011e-5\u4f5c\u4e3a\u9608\u503c\u7b5b\u9009\u6761\u4ef6<\/p>\n<p><strong>\u6ce8\uff1a1e-5\u9608\u503c\u9700\u8981\u540e\u7eed\u654f\u611f\u6027\u5206\u6790\u548c\u5f02\u8d28\u6027\u6027\u68c0\u9a8c\u7ed3\u679c\u589e\u52a0\u89e3\u91ca\u4f9d\u636e\u3002<\/strong><\/p>\n<p><strong>\u4e8c\u3001\u53bb\u9664\u8fde\u9501\u4e0d\u5e73\u8861(LD)<\/strong><\/p>\n<p>\u8bbe\u7f6er2=0.001\u548ckb=10000<\/p>\n<p>\u8868\u793a\u53bb\u6389\u572810000kb\u8303\u56f4\u5185\u4e0e\u6700\u663e\u8457SNP\u7684r2\u5927\u4e8e0.001\u7684SNP<\/p>\n<p>\u8bbe\u7f6e\u6210r2=0.3\u548ckb=1000<\/p>\n<p>\u8868\u793a\u7684\u5c31\u662f\u53bb\u6389\u57281000kb\u8303\u56f4\u5185\u4e0e\u6700\u663e\u8457SNP\u7684r2\u5927\u4e8e0.3\u7684SNP<\/p>\n<p>\u53c2\u6570\u8bbe\u7f6er2=0.01, kb=5000\u5373\u53ef\uff0c\u5982\u5728\u4e0a\u4e00\u6b65\u57fa\u7840\u4e0aSNP\u8fc7\u6ee4\u8f83\u591a\uff0c\u4e5f\u53ef\u8c03\u6574\u53c2\u6570\uff08r2=0.1, kb=5000\uff09<\/p>\n<p><strong>\u4e09\u3001\u7b5b\u9009MAF &gt;1%<\/strong><\/p>\n<p>MAF\u80af\u5b9a\u662f\uff1c0.5\u7684\uff0c\u56e0\u4e3a\u5982\u679c\uff1e0.5\uff0c\u90a3\u5c31\u4e0d\u662f\u7b2c\u4e8c\u591a\u3002\u5728GWAS\u7684summary\u6587\u4ef6\u91cc\u7ecf\u5e38\u6ca1\u6709MAF\u8fd9\u4e00\u5217\uff0c\u4f46\u662f\u6709EAF\u8fd9\u4e00\u5217\uff0c\u4ed6\u4eec\u4e4b\u95f4\u7684\u5173\u7cfb\u5c31\u662f\uff1a\u5982\u679cEAF\uff1e0.5\uff0c\u90a3\u4e48MAF=1-EAF\uff1b\u5982\u679cEAF\uff1c0.5\uff0c\u90a3\u4e48MAF=EAF\u3002<\/p>\n<p><strong>\u56db\u3001\u53bb\u9664\u5f31\u5de5\u5177\u53d8\u91cf<\/strong><\/p>\n<p>F\u68c0\u9a8c\u503c&gt;10\uff08\u4e00\u822cF\u7edf\u8ba1\u91cf\u5927\u4e8e10\u662f\u6bd4\u8f83\u597d\u7684\uff0c\u5f53\u7136\u80fd\u5927\u4e8e100\u662f\u66f4\u597d\u7684\uff09<\/p>\n<p>\u8ba1\u7b97\u65b9\u6cd5<\/p>\n<ol>\n<li>\u65b9\u6cd5\u4e00<\/li>\n<\/ol>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"375\" height=\"97\" class=\"wp-image-60641\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-1.png?resize=375%2C97\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-1.png?w=375 375w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-1.png?resize=300%2C78 300w\" sizes=\"(max-width: 375px) 100vw, 375px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u5176\u4e2dN\u8868\u793aGWAS\u5206\u6790\u4e2d\u7684\u6837\u672c\u91cf\uff1b k \u8868\u793a\u5de5\u5177\u53d8\u91cf\u7684\u4e2a\u6570\uff1b R^ {2} 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src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-2.png?resize=640%2C347\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-2.png?w=1146 1146w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-2.png?resize=300%2C163 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-2.png?resize=1024%2C556 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-2.png?resize=768%2C417 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-2.png?resize=600%2C326 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" 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https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-3.png?resize=600%2C288 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u4e0b\u6ed1\u754c\u9762\u53ef\u6d4f\u89c8\u68c0\u7d22\u5230\u76f8\u5e94\u6027\u72b6\u7ed3\u679c<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"220\" class=\"wp-image-60644\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-4.png?resize=640%2C220\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-4.png?w=1077 1077w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-4.png?resize=300%2C103 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-4.png?resize=1024%2C352 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-4.png?resize=768%2C264 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-4.png?resize=600%2C206 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u4f8b\u5982\u66b4\u9732\u56e0\u7d20\u662f\u5931\u7720<\/p>\n<p>\u7ed3\u5c40\u56e0\u7d20\u662f\u5fc3\u810f\u75c5<\/p>\n<p>\u68c0\u7d22\u7ed3\u679c\u53d1\u73b0\u6b64SNP\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u6709\u5173\uff0c\u90a3\u4e48\u8fd9\u4e2aSNP\u53ef\u80fd\u662f\u901a\u8fc7\u5fc3\u8840\u7ba1\u75be\u75c5\u5f71\u54cd\u7684\u5fc3\u810f\u75c5\uff0c\u56e0\u6b64\u9700\u8981\u67e5\u9605\u6587\u732e\u6392\u9664\u662f\u5426\u6b64SNP\u4e0e\u5fc3\u8840\u7ba1\u75be\u75c5\u6709\u5173\uff0c\u5982\u6709\u5efa\u8bae\u5254\u9664\u6b64SNP\u3002<\/p>\n<p>\u5982\u679cSNP\u6570\u636e\u91cf\u8f83\u591a\u53ef\u4ee5\u4e0a\u4f20\u6587\u672c\u6587\u4ef6\u6279\u91cf\u67e5\u8be2<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" width=\"413\" height=\"285\" class=\"wp-image-60645\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-5.png?resize=413%2C285\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-5.png?w=413 413w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-5.png?resize=300%2C207 300w\" sizes=\"(max-width: 413px) 100vw, 413px\" data-recalc-dims=\"1\" \/><\/p>\n<p><strong>\u6ce8\uff1aSNP\u6570\u76ee\u4e0d\u8981\u8d85\u8fc7100\u4e2a<\/strong><\/p>\n<p>\u6700\u540e\u63d0\u9192\u4e00\u4e0b\uff0cSNP\u6570\u76ee\u591a\u7684\u65f6\u5019\u7edf\u8ba1\u6548\u529b\u8db3\uff0c\u4f46\u662f\u5f02\u8d28\u6027\u548c\u591a\u6548\u6027\u53ef\u80fd\u4f1a\u6bd4\u8f83\u5927\uff0c\u5982\u679c\u53bb\u9664\u90e8\u5206SNP\u540e\uff0c\u53ef\u4ee5\u6d88\u9664\u5f02\u8d28\u6027\u548c\u591a\u6548\u6027\uff0c\u4f46\u662f\u4f1a\u5bfc\u81f4\u7edf\u8ba1\u6548\u529b\u4f4e\uff0c\u4f7f\u7ed3\u679c\u53d8\u6210\u9634\u6027\u3002\u56e0\u6b64\uff0c\u5927\u5bb6\u9700\u8981\u597d\u597d\u659f\u914c\u4e00\u4e0b\u81ea\u5df1\u7684\u7b5b\u9009\u9608\u503c\u6761\u4ef6\u3002\u4e0a\u8ff0\u9009\u53d6\u539f\u5219\u5177\u6709\u4e00\u5b9a\u666e\u9002\u6027\uff0c\u5e0c\u671b\u5927\u5bb6\u8bb0\u4f4f\uff0c\u611f\u5174\u8da3\u7684\u53ef\u4ee5\u6df1\u5165\u7406\u89e3\u4e00\u4e0b\u4e3a\u4ec0\u4e48\u9075\u5faa\u8fd9\u4e9b\u539f\u5219\u3002<\/p>\n<p><a id=\"post-60640-OLE_LINK1\"><\/a> \u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u2014\u2014\u5982\u4f55\u9009\u62e9\u5de5\u5177\u53d8\u91cf<\/p>\n<p><strong>\u4e00\u3001\u8868\u578bGWAS\u7ed3\u679c\u4e2d\u5177\u6709\u663e\u8457\u5173\u8054\u7684SNP<\/strong><\/p>\n<p>\u6807\u51c6\u9608\u503c\u5c0f\u4e8e5e-8\u663e\u8457\u4f4d\u70b9\uff08\u6bd4\u5982SNP\u4f4d\u70b9\u6570\u5927\u4e8e20\u4e2a\uff09\uff0c\u53ef\u4ee5\u76f4\u63a5\u8fdb\u884c\u540e\u7eed\u7684\u7b5b\u9009<\/p>\n<p>\u5982\u679c\u9608\u503c\u5c0f\u4e8e5e-8\u663e\u8457\u4f4d\u70b9\u53ea\u6709\u4e2a\u4f4d\u6570\uff0c\u751a\u81f3\u4e3a0\uff0c\u90a3\u4e48\u53ef\u4ee5\u5c1d\u8bd51e-7\u30011e-6\u30011e-5\u4f5c\u4e3a\u9608\u503c\u7b5b\u9009\u6761\u4ef6<\/p>\n<p><strong>\u6ce8\uff1a1e-5\u9608\u503c\u9700\u8981\u540e\u7eed\u654f\u611f\u6027\u5206\u6790\u548c\u5f02\u8d28\u6027\u6027\u68c0\u9a8c\u7ed3\u679c\u589e\u52a0\u89e3\u91ca\u4f9d\u636e\u3002<\/strong><\/p>\n<p><strong>\u4e8c\u3001\u53bb\u9664\u8fde\u9501\u4e0d\u5e73\u8861(LD)<\/strong><\/p>\n<p>\u8bbe\u7f6er2=0.001\u548ckb=10000<\/p>\n<p>\u8868\u793a\u53bb\u6389\u572810000kb\u8303\u56f4\u5185\u4e0e\u6700\u663e\u8457SNP\u7684r2\u5927\u4e8e0.001\u7684SNP<\/p>\n<p>\u8bbe\u7f6e\u6210r2=0.3\u548ckb=1000<\/p>\n<p>\u8868\u793a\u7684\u5c31\u662f\u53bb\u6389\u57281000kb\u8303\u56f4\u5185\u4e0e\u6700\u663e\u8457SNP\u7684r2\u5927\u4e8e0.3\u7684SNP<\/p>\n<p>\u53c2\u6570\u8bbe\u7f6er2=0.01, kb=5000\u5373\u53ef\uff0c\u5982\u5728\u4e0a\u4e00\u6b65\u57fa\u7840\u4e0aSNP\u8fc7\u6ee4\u8f83\u591a\uff0c\u4e5f\u53ef\u8c03\u6574\u53c2\u6570\uff08r2=0.1, kb=5000\uff09<\/p>\n<p><strong>\u4e09\u3001\u7b5b\u9009MAF 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src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-1-1.png?resize=375%2C97\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-1-1.png?w=375 375w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/word-image-60640-1-1.png?resize=300%2C78 300w\" sizes=\"(max-width: 375px) 100vw, 375px\" data-recalc-dims=\"1\" \/><\/p>\n<p>\u5176\u4e2dN\u8868\u793aGWAS\u5206\u6790\u4e2d\u7684\u6837\u672c\u91cf\uff1b k \u8868\u793a\u5de5\u5177\u53d8\u91cf\u7684\u4e2a\u6570\uff1b R^ {2} 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