{"id":60878,"date":"2024-09-12T15:51:29","date_gmt":"2024-09-12T07:51:29","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=60878"},"modified":"2024-09-12T15:51:29","modified_gmt":"2024-09-12T07:51:29","slug":"%e5%8d%95%e7%bb%86%e8%83%9e%e6%b5%8b%e5%ba%8f%e5%88%86%e6%9e%90%e8%bf%98%e8%83%bd%e6%80%8e%e4%b9%88%e5%8d%b7%ef%bc%9fmellon%e5%b8%a6%e4%bd%a0%e4%ba%86%e8%a7%a3%e5%8d%95%e7%bb%86%e8%83%9e%e5%88%86","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=60878","title":{"rendered":"\u5355\u7ec6\u80de\u6d4b\u5e8f\u5206\u6790\u8fd8\u80fd\u600e\u4e48\u5377\uff1fMellon\u5e26\u4f60\u4e86\u89e3\u5355\u7ec6\u80de\u5206\u5316\u8fc7\u7a0b\u4e2d\u7684\u7ec6\u80de\u5bc6\u5ea6\u53d8\u5316"},"content":{"rendered":"\n<p><strong>\u524d\u8a00<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u5927\u6d77\u54e5\u5728\u7fa4\u91cc\u770b\u5230\u5c0f\u4f19\u4f34\u4eec\u5bf9\u4e8e\u751f\u4fe1\u5206\u6790\u5230\u5e95\u8fd8\u80fd\u4e0d\u80fd\u53d1SCI\u8ba8\u8bba\u7684\u70ed\u706b\u671d\u5929\uff01\u5f88\u591a\u5c0f\u4f19\u4f34\u4eec@\u5927\u6d77\u54e5\uff0c\u60f3\u542c\u542c\u5927\u6d77\u54e5\u7684\u60f3\u6cd5\uff01\u4f20\u7edf\u7684\u8001\u5957\u8def\u60f3\u53d1SCI\u5b9e\u5728\u662f\u592a\u96be\u4e86\u3002\u600e\u6837\u624d\u80fd\u8131\u79bb\u751f\u4fe1\u5185\u5377\u8d5b\u9053\u53d1\u8868SCI\u5462\uff1f\u5bf9\u4e8e\u5927\u591a\u6570\u7684\u4e34\u5e8a\u533b\u751f\u6765\u8bf4\uff0c\u751f\u4fe1\u5206\u6790\u5f88\u96be\u518d\u7b97\u6cd5\u4e0a\u8fdb\u884c\u521b\uff0c\u90a3\u8fd8\u6709\u4ec0\u4e48\u529e\u6cd5\u5462\uff1f\u90a3\u5c31\u662f\u5377\u5de5\u4f5c\u91cf\u3001\u5377\u65b0\u7684\u5206\u6790\u65b9\u6cd5\uff01\u4eca\u5929\u5927\u6d77\u54e5\u5e26\u7740\u5927\u5bb6\u6765\u770b\u770b\u5355\u7ec6\u80de\u6d4b\u5e8f\u5206\u6790\u8fd8\u80fd\u600e\u4e48\u5377\uff1fMellon\u5e26\u4f60\u4e86\u89e3\u5355\u7ec6\u80de\u5206\u5316\u8fc7\u7a0b\u4e2d\u7684\u7ec6\u80de\u5bc6\u5ea6\u53d8\u5316\uff0c\u4e3a\u6307\u5bfc\u751f\u7269\u8f68\u8ff9\u7684\u673a\u5236\u63d0\u4f9b\u89c1\u89e3\u7684\u6f5c\u529b\u3002\u5c0f\u4f19\u4f34\u4eec\u5feb\u6765\u5b66\u4e60\u4e00\u4e0b\uff0c\u770b\u770b\u5982\u4f55\u5e94\u7528\u5230\u81ea\u5df1\u7684\u5206\u6790\u4e2d\u5145\u5b9e\u5de5\u4f5c\u91cf\u5462\uff01<\/p>\n\n\n\n<p>\u7ec3\u4e86\u5341\u5e74\u751f\u4fe1\u5206\u6790\u7684\u5927\u6d77\u54e5\u5bf9\u4e8e\u751f\u4fe1\u5206\u6790\u77e5\u8bc6\u5df2\u7ecf\u5982\u9c7c\u5f97\u6c34\uff0c\u76f8\u4fe1\u6709\u5927\u6d77\u54e5\u7684\u52a0\u6301\u4e00\u5b9a\u80fd\u8ba9\u5927\u5bb6\u5b66\u4f1a\uff01\u6ca1\u6709\u65f6\u95f4\u5b66\u4e60\u4e14\u6709\u751f\u4fe1\u5206\u6790\u7684\u5c0f\u4f19\u4f34\u4eec\u5feb\u6765\u6ef4\u6ef4\u5927\u6d77\u54e5\u5662\uff01\u4ece\u5206\u6790\u5230\u53ef\u89c6\u5316\u76f4\u5230\u4f60\u6ee1\u610f\u4e3a\u6b62\uff01<\/p>\n\n\n\n<p>\u5927\u6d77\u54e5\u5728\u8fd9\u91cc\u7ed9\u5927\u5bb6\u9001\u798f\u5229\u4e86\uff0c\u6709\u9700\u8981\u670d\u52a1\u5668\u7684\u5c0f\u4f19\u4f34\u4eec\uff0c\u6b22\u8fce\u5927\u5bb6\u540e\u53f0\u79c1\u4fe1\u5927\u6d77\u54e5\u54e6\uff0c\u4fdd\u8bc1\u670d\u52a1\u5668\u7684\u6027\u4ef7\u6bd4\u6700\u9ad8\u54e6\uff01<\/p>\n\n\n\n<p><strong>\u4ee3\u7801\u6559\u7a0b<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u672c\u6559\u7a0b\u63d0\u4f9b\u4e86\u5728\u5355\u7ec6\u80de RNA \u6d4b\u5e8f \uff08scRNA-seq\uff09 \u6570\u636e\u4e0a\u5e94\u7528Mellon\u5bc6\u5ea6\u4f30\u8ba1\u5668\u7684\u6307\u5357\u3002\u672c\u6559\u7a0b\u7684\u76ee\u7684\u662f\u8bf4\u660e\u4f7f\u7528 Mellon \u8f6f\u4ef6\u5305\u6267\u884c\u5bc6\u5ea6\u4f30\u8ba1\u6240\u9700\u7684\u6b65\u9aa4\u3002<\/p>\n\n\n\n<p>\u5728\u5f00\u59cb\u4e4b\u524d\uff0c\u8bf7\u786e\u4fdd\u5b89\u88c5\u4e86\u4ee5\u4e0b\u5fc5\u5907\u8f6f\u4ef6\u5305\uff0c\u8fd9\u4e9b\u8f6f\u4ef6\u5305\u5bf9\u4e8e\u5c06 Mellon \u4e0e scRNA-seq \u6570\u636e\u7ed3\u5408\u4f7f\u7528\u81f3\u5173\u91cd\u8981\uff1a<\/p>\n\n\n\n<ul>\n<li>scanpy\uff1a&nbsp;<a href=\"https:\/\/scanpy.readthedocs.io\/en\/stable\/installation.html\">https:\/\/scanpy.readthedocs.io\/en\/stable\/installation.html<\/a>\uff08\u5927\u6d77\u54e5\u5df2\u7ecf\u5e26\u7740\u5927\u5bb6\u5b66\u4e60\u8fc7\u4e86\u54e6\uff09<\/li>\n\n\n\n<li>palantir\uff1a&nbsp;<a href=\"https:\/\/github.com\/dpeerlab\/Palantir\">https:\/\/github.com\/dpeerlab\/Palantir<\/a>.\u6211\u4eec\u5efa\u8bae\u4f7f\u7528pip&nbsp;install&nbsp;git+https:\/\/github.com\/dpeerlab\/Palantir<\/li>\n<\/ul>\n\n\n\n<p><strong>1.\u52a0\u8f7d\u76f8\u5e94\u7684\u5305<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>import<\/strong>&nbsp;numpy <strong>as<\/strong>&nbsp;np<\/p>\n\n\n\n<p><strong>import<\/strong>&nbsp;matplotlib<\/p>\n\n\n\n<p><strong>import<\/strong>&nbsp;matplotlib.pyplot <strong>as<\/strong>&nbsp;plt<\/p>\n\n\n\n<p><strong>from<\/strong>&nbsp;sklearn.cluster <strong>import<\/strong>&nbsp;k_means<\/p>\n\n\n\n<p><strong>import<\/strong>&nbsp;palantir<\/p>\n\n\n\n<p><strong>import<\/strong>&nbsp;mellon<\/p>\n\n\n\n<p><strong>import<\/strong>&nbsp;scanpy <strong>as<\/strong>&nbsp;sc<\/p>\n\n\n\n<p><strong>import<\/strong>&nbsp;warnings<\/p>\n\n\n\n<p><strong>from<\/strong>&nbsp;numba.core.errors <strong>import<\/strong>&nbsp;NumbaDeprecationWarning<\/p>\n\n\n\n<p>warnings<strong>.<\/strong>simplefilter<strong>(<\/strong>&#8220;ignore&#8221;<strong>,<\/strong>&nbsp;category<strong>=<\/strong>NumbaDeprecationWarning<strong>)<\/strong><\/p>\n\n\n\n<p><strong>%matplotlib<\/strong>&nbsp;inline<\/p>\n\n\n\n<p>matplotlib<strong>.<\/strong>rcParams<strong>[<\/strong>&#8220;figure.figsize&#8221;<strong>]<\/strong>&nbsp;<strong>=<\/strong>&nbsp;<strong>[4,<\/strong>&nbsp;<strong>4]<\/strong><\/p>\n\n\n\n<p>matplotlib<strong>.<\/strong>rcParams<strong>[<\/strong>&#8220;figure.dpi&#8221;<strong>]<\/strong>&nbsp;<strong>=<\/strong>&nbsp;<strong>125<\/strong><\/p>\n\n\n\n<p>matplotlib<strong>.<\/strong>rcParams<strong>[<\/strong>&#8220;image.cmap&#8221;<strong>]<\/strong>&nbsp;<strong>=<\/strong>&nbsp;&#8220;Spectral_r&#8221;<\/p>\n\n\n\n<p><em># no bounding boxes or axis:<\/em><\/p>\n\n\n\n<p>matplotlib<strong>.<\/strong>rcParams<strong>[<\/strong>&#8220;axes.spines.bottom&#8221;<strong>]<\/strong>&nbsp;<strong>=<\/strong>&nbsp;&#8220;on&#8221;<\/p>\n\n\n\n<p>matplotlib<strong>.<\/strong>rcParams<strong>[<\/strong>&#8220;axes.spines.top&#8221;<strong>]<\/strong>&nbsp;<strong>=<\/strong>&nbsp;&#8220;off&#8221;<\/p>\n\n\n\n<p>matplotlib<strong>.<\/strong>rcParams<strong>[<\/strong>&#8220;axes.spines.left&#8221;<strong>]<\/strong>&nbsp;<strong>=<\/strong>&nbsp;&#8220;on&#8221;<\/p>\n\n\n\n<p>matplotlib<strong>.<\/strong>rcParams<strong>[<\/strong>&#8220;axes.spines.right&#8221;<strong>]<\/strong>&nbsp;<strong>=<\/strong>&nbsp;&#8220;off&#8221;<\/p>\n\n\n\n<p><strong>2. \u8bfb\u53d6\u548c\u663e\u793a\u6570\u636e\u96c6<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u6211\u4eec\u5c06\u4ece\u52a0\u8f7d&nbsp;scRNA-seq \u6570\u636e\u96c6\u5f00\u59cb\u3002\u6211\u4eec\u5c06\u4f7f\u7528\u9884\u5904\u7406\u7684 T \u7ec6\u80de\u8017\u7aed\u9aa8\u9ad3\u6570\u636e\u3002<\/p>\n\n\n\n<p>ad_url <strong>=<\/strong>&nbsp;&#8220;https:\/\/fh-pi-setty-m-eco-public.s3.amazonaws.com\/mellon-tutorial\/preprocessed_t-cell-depleted-bm-rna.h5ad&#8221;<\/p>\n\n\n\n<p>ad <strong>=<\/strong>&nbsp;sc<strong>.<\/strong>read<strong>(<\/strong>&#8220;data\/preprocessed_t-cell-depleted-bm-rna.h5ad&#8221;<strong>,<\/strong>&nbsp;backup_url<strong>=<\/strong>ad_url<strong>)<\/strong><\/p>\n\n\n\n<p>ad<\/p>\n\n\n\n<p>sc.pl.scatter(ad, basis=&#8221;umap&#8221;, color=&#8221;celltype&#8221;)<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"362\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72471-7.png?resize=640%2C362\" alt=\"\" class=\"wp-image-60879\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72471-7.png?w=858 858w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72471-7.png?resize=300%2C170 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72471-7.png?resize=768%2C434 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72471-7.png?resize=600%2C339 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p><strong>3. \u9884\u5904\u7406<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u6211\u4eec\u5c06\u4f7f\u7528\u6269\u6563\u56fe\u4f5c\u4e3a\u7ec6\u80de\u72b6\u6001\u8868\u793a\u7684\u8f93\u5165\u4f5c\u4e3a&nbsp;Mellon \u7684\u8f93\u5165\u3002\u6269\u6563\u56fe\u901a\u8fc7\u521b\u5efa\u4fdd\u6301\u7ec6\u80de\u4e4b\u95f4\u5173\u7cfb\u7684\u964d\u7ef4\u8868\u793a\u6765\u6355\u83b7\u6570\u636e\u7684\u56fa\u6709\u51e0\u4f55\u5f62\u72b6\u3002\u53ef\u4ee5\u4f7f\u7528\u8be5\u51fd\u6570\u8ba1\u7b97\u6269\u6563\u56fe\u3002\u9ed8\u8ba4\u60c5\u51b5\u4e0b\uff0c\u6b64\u51fd\u6570\u4f7f\u7528\u9884\u5148\u8ba1\u7b97\u7684\u51fd\u6570\uff0c\u4f46\u53ef\u4ee5\u66f4\u6539\u4e3a\u4f7f\u7528 anndata \u5bf9\u8c61\u4e2d\u7684\u4efb\u4f55\u6761\u76ee\u3002<\/p>\n\n\n\n<p>%%time<\/p>\n\n\n\n<p>dm_res = palantir.utils.run_diffusion_maps(ad, pca_key=&#8221;X_pca&#8221;, n_components=20)<\/p>\n\n\n\n<p><strong>4. \u5bc6\u5ea6\u8ba1\u7b97<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u5728\u6b64\u6b65\u9aa4\u4e2d\uff0c\u6211\u4eec\u5c06\u4f7f\u7528&nbsp;Mellon \u7684 DensityEstimator \u7c7b\u8ba1\u7b97\u7ec6\u80de\u72b6\u6001\u5bc6\u5ea6\u3002\u4e0a\u9762\u8ba1\u7b97\u7684\u6269\u6563\u5206\u91cf\u7528\u4f5c\u8f93\u5165\u3002\u53ef\u4ee5\u4f7f\u7528UMAP\u53ef\u89c6\u5316\u8ba1\u7b97\u5bc6\u5ea6\u3002<\/p>\n\n\n\n<p>%%time<\/p>\n\n\n\n<p>model = mellon.DensityEstimator()<\/p>\n\n\n\n<p>log_density = model.fit_predict(ad.obsm[&#8220;DM_EigenVectors&#8221;])<\/p>\n\n\n\n<p>predictor = model.predict<\/p>\n\n\n\n<p>ad.obs[&#8220;mellon_log_density&#8221;] = log_density<\/p>\n\n\n\n<p>ad.obs[&#8220;mellon_log_density_clipped&#8221;] = np.clip(<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;log_density, *np.quantile(log_density, [0.05, 1])<\/p>\n\n\n\n<p>)<\/p>\n\n\n\n<p>ad<\/p>\n\n\n\n<p>sc.pl.scatter(<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;ad, color=[&#8220;mellon_log_density&#8221;, &#8220;mellon_log_density_clipped&#8221;], basis=&#8221;umap&#8221;<\/p>\n\n\n\n<p>)<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"306\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72472-3.png?resize=640%2C306\" alt=\"\" class=\"wp-image-60880\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72472-3.png?w=1015 1015w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72472-3.png?resize=300%2C143 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72472-3.png?resize=768%2C367 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72472-3.png?resize=600%2C287 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p><strong>5.\u5206\u6790\u7ec6\u80de\u7c7b\u578b<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u53ef\u4ee5\u4f7f\u7528\u8ba1\u7b97\u51fa\u7684\u7ec6\u80de\u5bc6\u5ea6\u6765\u5206\u6790\u6570\u636e\u96c6\u4e2d\u7684\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u3002<\/p>\n\n\n\n<p>fig, (ax1, ax2) = plt.subplots(1, 2, width_ratios=[3, 2], figsize=[12, 4])<\/p>\n\n\n\n<p>sc.pl.violin(ad, &#8220;mellon_log_density&#8221;, &#8220;celltype&#8221;, rotation=45, ax=ax1, show=False)<\/p>\n\n\n\n<p>sc.pl.scatter(ad, color=&#8221;celltype&#8221;, basis=&#8221;umap&#8221;, ax=ax2, show=False)<\/p>\n\n\n\n<p>plt.show()<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"211\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72473-5.png?resize=640%2C211\" alt=\"\" class=\"wp-image-60881\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72473-5.png?resize=1024%2C337 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72473-5.png?resize=300%2C99 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72473-5.png?resize=768%2C253 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72473-5.png?resize=600%2C197 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72473-5.png?w=1277 1277w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p>#\u6cbf\u4f2a\u65f6\u95f4\u7684\u5bc6\u5ea6\u6bd4\u8f83<\/p>\n\n\n\n<p>##\u5bc6\u5ea6\u53ef\u4ee5\u4e0e\u4f2a\u65f6\u95f4\u8f74\u6216\u5176\u4ed6\u8f74\u8fdb\u884c\u6bd4\u8f83\uff0c\u4ee5\u8bc6\u522b\u9ad8\u5bc6\u5ea6\u548c\u4f4e\u5bc6\u5ea6\u533a\u57df\u3002<\/p>\n\n\n\n<p>ad.obs[&#8220;palantir_pseudotime&#8221;], ad.obsm[&#8220;palantir_lineage_cells&#8221;]<\/p>\n\n\n\n<p>##\u6211\u4eec\u5c06\u63a2\u7d22\u6cbf&nbsp;B \u7ec6\u80de\u8c31\u7cfb\u7684\u5bc6\u5ea6<\/p>\n\n\n\n<p>bcell_lineage_cells = ad.obs_names[ad.obsm[&#8220;palantir_lineage_cells&#8221;][&#8220;NaiveB&#8221;]]<\/p>\n\n\n\n<p>palantir.plot.highlight_cells_on_umap(ad, bcell_lineage_cells)<\/p>\n\n\n\n<p>plt.show()<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"412\" height=\"410\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72474-3.png?resize=412%2C410\" alt=\"\" class=\"wp-image-60882\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72474-3.png?w=412 412w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72474-3.png?resize=300%2C300 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72474-3.png?resize=150%2C150 150w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72474-3.png?resize=100%2C100 100w\" sizes=\"(max-width: 412px) 100vw, 412px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p>import pandas as pd<\/p>\n\n\n\n<p>ct_colors = pd.Series(<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;ad.uns[&#8220;celltype_colors&#8221;], index=ad.obs[&#8220;celltype&#8221;].values.categories<\/p>\n\n\n\n<p>)<\/p>\n\n\n\n<p>plt.figure(figsize=[8, 3])<\/p>\n\n\n\n<p>plt.scatter(<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;ad.obs[&#8220;palantir_pseudotime&#8221;][bcell_lineage_cells],<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;ad.obs[&#8220;mellon_log_density&#8221;][bcell_lineage_cells],<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;s=10,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;color=ct_colors[ad.obs[&#8220;celltype&#8221;][bcell_lineage_cells]],<\/p>\n\n\n\n<p>)<\/p>\n\n\n\n<p>plt.show()<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"268\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72475-5.png?resize=640%2C268\" alt=\"\" class=\"wp-image-60883\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72475-5.png?w=858 858w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72475-5.png?resize=300%2C126 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72475-5.png?resize=768%2C321 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72475-5.png?resize=600%2C251 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p>palantir.plot.plot_branch(<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;ad,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;branch_name=&#8221;NaiveB&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;position=&#8221;mellon_log_density&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;color=&#8221;celltype&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;masks_key=&#8221;palantir_lineage_cells&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;s=100,<\/p>\n\n\n\n<p>)<\/p>\n\n\n\n<p>plt.show()<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"179\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72476-4.png?resize=640%2C179\" alt=\"\" class=\"wp-image-60884\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72476-4.png?resize=1024%2C287 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72476-4.png?resize=300%2C84 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72476-4.png?resize=768%2C215 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72476-4.png?resize=600%2C168 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72476-4.png?w=1281 1281w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p>\u8be5\u56fe\u6e05\u695a\u5730\u8bf4\u660e\u4e86\u5b9a\u4e49&nbsp;B \u7ec6\u80de\u5206\u5316\u7684\u4ea4\u66ff\u9ad8\u5bc6\u5ea6\u548c\u4f4e\u5bc6\u5ea6\u533a\u57df\u3002\u53ef\u4ee5\u68c0\u67e5\u8fd9\u79cd\u53d8\u5f02\u6027\u4ee5\u8bc6\u522b\u9ad8\u5bc6\u5ea6\u548c\u4f4e\u5bc6\u5ea6\u533a\u57df.<\/p>\n\n\n\n<p>##\u76f8\u540c\u7684\u529f\u80fd\u53ef\u7528\u4e8e\u53ef\u89c6\u5316\u57fa\u56e0\u8868\u8fbe<\/p>\n\n\n\n<p># \u5728\u4f2a\u65f6\u95f4\u548c\u5bf9\u6570\u5bc6\u5ea6\u7684\u6bd4\u8f83\u4e2d\u7ed8\u5236EBF1\u7684\u4f30\u7b97\u8868\u8fbe<\/p>\n\n\n\n<p>palantir.plot.plot_branch(<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;ad,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;branch_name=&#8221;NaiveB&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;position=&#8221;mellon_log_density&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;color=&#8221;EBF1&#8243;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;color_layer=&#8221;MAGIC_imputed_data&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;masks_key=&#8221;palantir_lineage_cells&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;s=100,<\/p>\n\n\n\n<p>)<\/p>\n\n\n\n<p>plt.show()<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"216\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72477-3.png?resize=640%2C216\" alt=\"\" class=\"wp-image-60885\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72477-3.png?resize=1024%2C346 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72477-3.png?resize=300%2C101 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72477-3.png?resize=768%2C260 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72477-3.png?resize=600%2C203 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72477-3.png?w=1283 1283w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p><strong>6\u8868\u8fbe\u7684\u5c40\u90e8\u53d8\u5f02\u6027\u6216\u5c40\u90e8\u53d8\u5316<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u5c40\u90e8\u53d8\u5f02\u6027\u63d0\u4f9b\u4e86\u6bcf\u4e2a\u7ec6\u80de\u72b6\u6001\u7684\u57fa\u56e0\u8868\u8fbe\u53d8\u5316\u7684\u5ea6\u91cf\u3002\u8fd9\u662f\u901a\u8fc7\u5c06\u7ec6\u80de\u4e2d\u7684\u57fa\u56e0\u4e0e\u5176\u76f8\u90bb\u7ec6\u80de\u72b6\u6001\u8fdb\u884c\u6bd4\u8f83\u6765\u786e\u5b9a\u7684\uff0c\u5e76\u4e14\u53ef\u4ee5\u4f7f\u7528\u4ee5\u4e0b\u65b9\u6cd5\u8ba1\u7b97:palantir.utils.run_local_variability<\/p>\n\n\n\n<p># \u57fa\u56e0\u7684\u5c40\u90e8\u53d8\u5316<\/p>\n\n\n\n<p>palantir.utils.run_local_variability(ad)<\/p>\n\n\n\n<p>#\u8fd9\u5c06\u6dfb\u52a0&#8217; local_variability &#8216;\u4f5c\u4e3a\u4e00\u4e2a\u56fe\u5c42\u5230anndata<\/p>\n\n\n\n<p>ad<\/p>\n\n\n\n<p># \u5c40\u90e8\u53ef\u53d8\u6027\u6216\u5c40\u90e8\u53d8\u5316\u4e5f\u53ef\u4ee5\u4f7f\u7528&#8217; plot_branch &#8216;\u51fd\u6570\u8fdb\u884c\u53ef\u89c6\u5316<\/p>\n\n\n\n<p>palantir.plot.plot_branch(<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;ad,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;branch_name=&#8221;NaiveB&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;position=&#8221;mellon_log_density&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;color=&#8221;EBF1&#8243;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;color_layer=&#8221;local_variability&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;masks_key=&#8221;palantir_lineage_cells&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;s=100,<\/p>\n\n\n\n<p>)<\/p>\n\n\n\n<p>plt.show()<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"214\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72479-1.png?resize=640%2C214\" alt=\"\" class=\"wp-image-60886\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72479-1.png?resize=1024%2C343 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72479-1.png?resize=300%2C101 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72479-1.png?resize=768%2C258 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72479-1.png?resize=600%2C201 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u72479-1.png?w=1270 1270w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p>#\u4f7f\u7528\u84dd\u8272\u8272\u56fe\u6765\u7ed8\u5236\u53d8\u5316<\/p>\n\n\n\n<p>palantir.plot.plot_branch(<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;ad,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;branch_name=&#8221;NaiveB&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;position=&#8221;mellon_log_density&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;color=&#8221;EBF1&#8243;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;color_layer=&#8221;local_variability&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;masks_key=&#8221;palantir_lineage_cells&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;s=100,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;cmap=matplotlib.cm.Blues,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;edgecolor=&#8221;black&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;linewidth=0.1,<\/p>\n\n\n\n<p>)<\/p>\n\n\n\n<p>plt.show()<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"214\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u724710-2.png?resize=640%2C214\" alt=\"\" class=\"wp-image-60887\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u724710-2.png?resize=1024%2C343 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u724710-2.png?resize=300%2C101 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u724710-2.png?resize=768%2C257 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u724710-2.png?resize=600%2C201 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u724710-2.png?w=1310 1310w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p># umap\u53ef\u4ee5\u4e0e\u7ec6\u80de\u5b50\u96c6\u4e00\u8d77\u7ed8\u5236\u4ee5\u63a2\u7d22\u5bc6\u5ea6<\/p>\n\n\n\n<p>sc.pl.embedding(<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;ad[bcell_lineage_cells],<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;basis=&#8221;umap&#8221;,<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;color=[&#8220;mellon_log_density_clipped&#8221;, &#8220;celltype&#8221;],<\/p>\n\n\n\n<p>)<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"640\" height=\"259\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u724711-2.png?resize=640%2C259\" alt=\"\" class=\"wp-image-60888\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u724711-2.png?resize=1024%2C415 1024w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u724711-2.png?resize=300%2C121 300w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u724711-2.png?resize=768%2C311 768w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u724711-2.png?resize=600%2C243 600w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/\u56fe\u724711-2.png?w=1161 1161w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p><strong>7. \u4fdd\u5b58\u548c\u52a0\u8f7d\u53d8\u91cf<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u53ef\u4ee5\u5c06\u9884\u6d4b\u53d8\u91cf\u5e8f\u5217\u5316\u5230\u5b57\u5178\u4e2d\uff0c\u5e76\u76f4\u63a5\u4fdd\u5b58\u5728&nbsp;Anndata \u5bf9\u8c61\u4e2d\u3002\u7136\u540e\uff0c\u6211\u4eec\u53ef\u4ee5\u5c06 Anndata \u5bf9\u8c61\u5199\u5165\u78c1\u76d8\uff0c\u91cd\u65b0\u52a0\u8f7d\u5b83\uff0c\u4ece\u4fdd\u5b58\u7684\u5b57\u5178\u4e2d\u91cd\u6784\u9884\u6d4b\u5668\uff0c\u5e76\u5c06\u5176\u5e94\u7528\u4e8e\u6211\u4eec\u7684\u6570\u636e\u3002\u6700\u7ec8\u68c0\u67e5\u9a8c\u8bc1\u53cd\u5e8f\u5217\u5316\u5bc6\u5ea6\u51fd\u6570\u662f\u5426\u4e0e\u539f\u59cb\u51fd\u6570\u76f8\u540c\u3002<\/p>\n\n\n\n<p># \u8f6c\u6362\u4e3a\u5b57\u5178\u5e76\u4fdd\u5b58\u5230Anndata\uff0c\u7136\u540e\u5c06Anndata\u5199\u5165\u78c1\u76d8<\/p>\n\n\n\n<p>ad.uns[&#8220;log_density_function&#8221;] = predictor.to_dict()<\/p>\n\n\n\n<p>ad.write(&#8220;data\/adata.h5ad&#8221;)<\/p>\n\n\n\n<p>#\u52a0\u8f7d\u53d8\u91cf<\/p>\n\n\n\n<p>#\u91cd\u65b0\u52a0\u8f7dAnndata<\/p>\n\n\n\n<p>ad = sc.read(&#8220;data\/adata.h5ad&#8221;)<\/p>\n\n\n\n<p>predictor = mellon.Predictor.from_dict(ad.uns[&#8220;log_density_function&#8221;])<\/p>\n\n\n\n<p># \u9a8c\u8bc1<\/p>\n\n\n\n<p>log_density = predictor(ad.obsm[&#8220;DM_EigenVectors&#8221;])<\/p>\n\n\n\n<p>assert np.all(<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;np.isclose(log_density, ad.obs[&#8220;mellon_log_density&#8221;])<\/p>\n\n\n\n<p>), &#8220;Deserialized density function differs from original.&#8221;<\/p>\n\n\n\n<p><strong>\u5c0f\u7ed3<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u7ec6\u80de\u72b6\u6001\u5bc6\u5ea6\u8868\u5f81\u4e86\u7ec6\u80de\u6cbf\u8868\u578b\u666f\u89c2\u7684\u5206\u5e03\uff0c\u5bf9\u4e8e\u63ed\u793a\u9a71\u52a8\u4e0d\u540c\u751f\u7269\u8fc7\u7a0b\u7684\u673a\u5236\u81f3\u5173\u91cd\u8981\u3002\u5728\u8fd9\u91cc\uff0c\u5927\u6d77\u54e5\u7ed9\u5c0f\u4f19\u4f34\u4eec\u4ecb\u7ecd\u4e86Mellon\uff0c\u4e00\u79cd\u4ece\u5355\u7ec6\u80de\u6570\u636e\u7684\u9ad8\u7ef4\u8868\u793a\u4e2d\u4f30\u8ba1\u7ec6\u80de\u72b6\u6001\u5bc6\u5ea6\u7684\u7b97\u6cd5\u3002Mellon \u6709\u52a9\u4e8e\u8de8\u5404\u79cd\u5355\u7ec6\u80de\u6570\u636e\u6a21\u5f0f\u8fdb\u884c\u5bc6\u5ea6\u4f30\u8ba1\uff0c\u5e76\u968f\u7ec6\u80de\u6570\u91cf\u7ebf\u6027\u7f29\u653e\uff0c\u8fd9\u5728\u7ec6\u80de\u72b6\u6001\u5bc6\u5ea6\u5728\u7406\u89e3\u5206\u5316\u8fc7\u7a0b\u65b9\u9762\u7684\u91cd\u8981\u6027\u3002\u6700\u540e\u5927\u6d77\u54e5\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e00\u4e2a\u4e91\u5de5\u5177\uff01\u540c\u5b66\u4eec\u5982\u679c\u89c9\u5f97\u81ea\u5df1\u7684\u4ee3\u7801\u6c34\u5e73\u4e00\u822c\uff0c\u5bf9\u4e8e\u5f88\u591a\u7684\u53c2\u6570\u4e0d\u77e5\u9053\u600e\u4e48\u6539\uff0c\u53ef\u4ee5\u4f53\u9a8c\u4e00\u4e0b\u6211\u4eec\u7684\u4e91\u751f\u4fe1\u5c0f\u5de5\u5177\uff0c\u53ea\u9700\u8f93\u5165\u6570\u636e\uff0c\u5373\u53ef\u8f7b\u677e\u751f\u6210\u6240\u9700\u56fe\u8868\uff0c\u5b57\u4f53\u5927\u5c0f\u3001\u6807\u9898\u7b49\u4e5f\u53ef\u4e00\u952e\u66f4\u6539\u3002\u611f\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u53bb\u4e91\u751f\u4fe1\uff08http:\/\/www.biocloudservice.com\/home.html\uff09\u4f53\u9a8c\u4e00\u4e0b\u5427\uff01<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/b83a70e861b85da4e5d054d57384bcfc-6.png?resize=640%2C285\" alt=\"\" class=\"wp-image-60889\" width=\"640\" height=\"285\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/b83a70e861b85da4e5d054d57384bcfc-6.png?w=553 553w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/09\/b83a70e861b85da4e5d054d57384bcfc-6.png?resize=300%2C133 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" data-recalc-dims=\"1\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u524d\u8a00 \u5927\u6d77\u54e5\u5728\u7fa4\u91cc\u770b\u5230\u5c0f\u4f19\u4f34\u4eec\u5bf9\u4e8e\u751f\u4fe1\u5206\u6790\u5230\u5e95\u8fd8\u80fd\u4e0d\u80fd\u53d1SCI\u8ba8\u8bba\u7684\u70ed\u706b\u671d\u5929\uff01\u5f88\u591a\u5c0f\u4f19\u4f34\u4eec@\u5927\u6d77\u54e5\uff0c\u60f3\u542c\u542c\u5927\u6d77 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[1],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/60878"}],"collection":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=60878"}],"version-history":[{"count":1,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/60878\/revisions"}],"predecessor-version":[{"id":60890,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/60878\/revisions\/60890"}],"wp:attachment":[{"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=60878"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=60878"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.biocloudservice.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=60878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}