{"id":61106,"date":"2024-10-17T10:45:38","date_gmt":"2024-10-17T02:45:38","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=61106"},"modified":"2024-10-17T10:45:38","modified_gmt":"2024-10-17T02:45:38","slug":"%e7%94%9f%e4%bf%a1%e5%bf%85%e7%9c%8b%ef%bc%81%ef%bc%81%ef%bc%81alphafold-3%ef%bc%8c%e6%b7%b1%e5%ba%a6%e5%ad%a6%e4%b9%a0%e5%b7%a8%e5%8c%a0%e7%9a%84%e7%bb%93%e6%99%b6%ef%bc%8c%e7%b2%be%e5%87%86%e9%a2%84","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=61106","title":{"rendered":"\u751f\u4fe1\u5fc5\u770b\uff01\uff01\uff01AlphaFold 3\uff0c\u6df1\u5ea6\u5b66\u4e60\u5de8\u5320\u7684\u7ed3\u6676\uff0c\u7cbe\u51c6\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u5f15\u9886\u79d1\u5b66\u524d\u6cbf\uff01"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"554\" height=\"153\" 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Server\u5e73\u53f0\u9884\u6d4b\u4eba\u4f53\u8840\u7ea2\u86cb\u767d\u03b2\u4e9a\u57fa\uff08Hemoglobin subunit beta, HBB\uff09\u7684\u4e09\u7ef4\u7ed3\u6784\u5427\u3002<\/p>\n\n\n\n<p><strong>\u6570\u636e\u51c6\u5907<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u5728\u672c\u6587\u4e2d\uff0c\u5927\u6d77\u54e5\u5c06\u91c7\u7528\u4eba\u4f53\u8840\u7ea2\u86cb\u767d\u03b2\u4e9a\u57fa\uff08HBB\uff09\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u4e3a\u793a\u4f8b\u6587\u4ef6\uff08example.fasat\uff09\uff0c\u8be5\u6587\u4ef6\u4eceUniport\u6570\u636e\u5e93\u4e0b\u8f7d\u800c\u6765\u3002\u540c\u5b66\u4eec\u53ef\u4ee5\u4f7f\u7528\u81ea\u5df1\u7814\u7a76\u7684\u86cb\u767d\u8d28\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u4e5f\u53ef\u4ee5\u4eceUniport\u7f51\u9875\u83b7\u53d6\u5176\u5b83\u86cb\u767d\u8d28\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u6765\u8fdb\u884c\u7ed3\u6784\u9884\u6d4b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"554\" height=\"119\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132325748_9E6E852B-00E9-435a-BDF9-DF19A1325D54.png?resize=554%2C119\" alt=\"\" class=\"wp-image-61113\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132325748_9E6E852B-00E9-435a-BDF9-DF19A1325D54.png?w=554 554w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132325748_9E6E852B-00E9-435a-BDF9-DF19A1325D54.png?resize=300%2C64 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p>Uniport\u7f51\u9875\u548cexample.fasat\u6587\u4ef6\u5e8f\u5217\u4fe1\u606f\u4e0a\u56fe\u6240\u793a\u3002<\/p>\n\n\n\n<p><strong>\u8fdb\u884c\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u9996\u5148\uff0c\u6211\u4eec\u9700\u8981\u628a\u9700\u8981\u6dfb\u52a0\u4e00\u4e2a\u86cb\u767d\u8d28\u7684\u6761\u76ee\uff0c\u8bbe\u7f6e\u62f7\u8d1d\u6570\u4e3a1\uff0c\u968f\u540e\u628a\u4eba\u4f53\u8840\u7ea2\u86cb\u767d\u03b2\u4e9a\u57fa\uff08HBB\uff09\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u586b\u5165\u540e\u8fb9\u7684\u5e8f\u5217\u7f16\u8f91\u6846\u4e2d\uff0c\u8ba9\u5982\u4e0b\u56fe\u6240\u793a\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"554\" height=\"138\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132334428_92DA875D-F406-4b3b-BF93-49BCA0D5D7E8-1.png?resize=554%2C138\" alt=\"\" class=\"wp-image-61117\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132334428_92DA875D-F406-4b3b-BF93-49BCA0D5D7E8-1.png?w=554 554w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132334428_92DA875D-F406-4b3b-BF93-49BCA0D5D7E8-1.png?resize=300%2C75 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p>\u70b9\u51fb\u201cContinue and preview job\u201d\u540e\uff0c\u5c06Job name\u8bbe\u7f6e\u4e3aHBB\uff0c\u4e0d\u4f7f\u7528Seed\u8fdb\u884c\u9884\u6d4b\uff0c\u968f\u540e\u70b9\u51fb\u201cConfirm and submit job\u201d\u8fdb\u884c\u9879\u76ee\u63d0\u4ea4\u9884\u6d4b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"554\" height=\"235\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132342628_AE2E65A9-2236-4418-99AC-D9424C11137D-1.png?resize=554%2C235\" alt=\"\" class=\"wp-image-61120\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132342628_AE2E65A9-2236-4418-99AC-D9424C11137D-1.png?w=554 554w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132342628_AE2E65A9-2236-4418-99AC-D9424C11137D-1.png?resize=300%2C127 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p>\u8010\u5fc3\u7b49\u5f85\u9884\u6d4b\u7ed3\u675f\u540e\uff0c\u70b9\u51fb\u9879\u76ee\u540d\u79f0\u5373\u53ef\u67e5\u770b\u9884\u6d4b\u7ed3\u679c\uff0c\u70b9\u51fbDowload\u5373\u53ef\u4e0b\u8f7d\u7ed3\u679c\uff0c\u9884\u6d4b\u7ed3\u679c\u5982\u4e0b\u56fe\u6240\u793a\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132351475_039350D5-03F6-4b00-A690-2584419FA058-1.png?resize=554%2C56\" alt=\"\" class=\"wp-image-61119\" width=\"554\" height=\"56\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132351475_039350D5-03F6-4b00-A690-2584419FA058-1.png?w=554 554w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132351475_039350D5-03F6-4b00-A690-2584419FA058-1.png?resize=300%2C30 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" loading=\"lazy\" width=\"554\" height=\"374\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132360735_5CBEE39B-C7D4-48a0-9A22-1EC7DFF1B9CA.png?resize=554%2C374\" alt=\"\" class=\"wp-image-61118\" srcset=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132360735_5CBEE39B-C7D4-48a0-9A22-1EC7DFF1B9CA.png?w=554 554w, https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/10\/1729132360735_5CBEE39B-C7D4-48a0-9A22-1EC7DFF1B9CA.png?resize=300%2C203 300w\" sizes=\"(max-width: 554px) 100vw, 554px\" data-recalc-dims=\"1\" \/><\/figure>\n\n\n\n<p>\u7531\u9884\u6d4b\u7ed3\u679c\u6211\u4eec\u53ef\u77e5\uff0c\u4eba\u4f53\u8840\u7ea2\u86cb\u767d\u03b2\u4e9a\u57fa\uff08HBB\uff09\u7684\u4e8c\u7ea7\u7ed3\u6784\u7531\u4e00\u7cfb\u5217 \u03b1-\u87ba\u65cb\u3001\u03b2-\u8f6c\u89d2\u548c\u65e0\u89c4\u5377\u66f2\u7ec4\u6210\u3002HBB \u7684\u4e8c\u7ea7\u7ed3\u6784\u4e3b\u8981\u7531 \u03b1-\u87ba\u65cb\u6784\u6210\uff0c\u5171\u6709 8 \u4e2a \u03b1-\u87ba\u65cb\uff0c\u6bcf\u4e2a \u03b1-\u87ba\u65cb\u7531\u7a33\u5b9a\u7684\u6c22\u952e\u7ef4\u6301\uff0c\u5176\u6c28\u57fa\u9178\u4fa7\u94fe\u5411\u5916\u5ef6\u4f38\u3002\u8fd9\u4e9b \u03b1-\u87ba\u65cb\u5728\u7a7a\u95f4\u4e0a\u76f8\u4e92\u6392\u5217\uff0c\u5f62\u6210\u7a33\u5b9a\u7684\u4e09\u7ef4\u7ed3\u6784\u3002\u5728\u4e00\u4e9b 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