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CYTOSCAPE<\/strong><\/strong><\/h3>\n\n\n\n

Cytoscape\u662f\u4e00\u6b3e\u4e13\u6ce8\u4e8e\u5f00\u6e90\u7f51\u7edc\u53ef\u89c6\u5316\u548c\u5206\u6790\u7684\u8f6f\u4ef6\u3002\u5b83\u7684\u6838\u5fc3\u529f\u80fd\u662f\u63d0\u4f9b\u57fa\u7840\u7684\u7f51\u7edc\u5e03\u5c40\u548c\u67e5\u8be2\u529f\u80fd\uff0c\u5c06\u7f51\u7edc\u6570\u636e\u53ef\u89c6\u5316\u4e3a\u56fe\u5f62\u3002\u7f51\u7edc\u7684\u6bcf\u4e2a\u8282\u70b9\u53ef\u4ee5\u662f\u57fa\u56e0\u3001miRNA\u6216\u86cb\u767d\u8d28\u7b49\uff0c\u800c\u8282\u70b9\u4e0e\u8282\u70b9\u4e4b\u95f4\u7684\u8fde\u63a5\uff08\u8fb9\uff09\u5219\u4ee3\u8868\u7740\u8fd9\u4e9b\u8282\u70b9\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5982\u86cb\u767d\u4e0e\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\uff08pp\uff09\u3001DNA\u4e0e\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\uff08pd\uff09\u7b49\u3002<\/p>\n\n\n\n

Cytoscape\u4e5f\u975e\u5e38\u4fbf\u4e8e\u64cd\u4f5c\uff0c\u5b83\u652f\u6301\u591a\u79cd\u7f51\u7edc\u63cf\u8ff0\u683c\u5f0f\uff0c\u4e5f\u53ef\u4ee5\u7528\u4ee5Tab\u5236\u8868\u7b26\u5206\u9694\u7684\u6587\u672c\u6587\u6863\u6216Microsoft Excel\u6587\u4ef6\u4f5c\u4e3a\u8f93\u5165\uff0c\u6216\u8005\u5229\u7528Cytoscape\u8f6f\u4ef6\u672c\u8eab\u7684\u7f16\u8f91\u5668\u6a21\u5757\u76f4\u63a5\u6784\u5efa\u7f51\u7edc\uff0c\u64cd\u4f5c\u65b9\u5f0f\u4fbf\u6377\u3002\u6211\u4eec\u8fd8\u53ef\u4ee5\u81ea\u5b9a\u4e49\u8282\u70b9\u548c\u8fb9\u7684\u6837\u5f0f\u3001\u989c\u8272\u3001\u5f62\u72b6\u7b49\uff0c\u4ee5\u53ca\u5bf9\u7f51\u7edc\u8fdb\u884c\u5e03\u5c40\u548c\u6392\u5217\u3002<\/p>\n\n\n\n

\u8fd9\u91cc\u5c0f\u679c\u5c06\u6211\u4eec\u521a\u521a\u7684tsv\u6587\u4ef6\u5bfc\u5165\u540e\uff0c\u5f97\u5230\u4e86\u4e00\u4e2a\u7f51\u7edc\u56fe\u5f62\u3002\u5728\u5de6\u8fb9\u7684\u6587\u4ef6\u540d\u540e\u663e\u793a\u76ee\u524d\u6709225\u4e2a\u8282\u70b9\u548c4464\u6761\u8fb9\uff1a<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u63a5\u4e0b\u6765\u6211\u4eec\u4e0b\u8f7dcentiscape2.2\u63d2\u4ef6\uff0c\u8fd9\u662f\u5c0f\u679c\u5e38\u7528\u7684\u4e00\u4e2a\u7b5b\u9009\u63d2\u4ef6\uff0c\u91cc\u9762\u6709\u5f88\u591a\u7b5b\u9009\u56e0\u7d20\uff0c\u5c0f\u679c\u5728\u8fd9\u91cc\u8ddf\u5927\u5bb6\u8be6\u7ec6\u4ecb\u7ecd\u4e00\u4e0b\u6211\u4eec\u8981\u7528\u5230BETWENESS\u3001CLOSENESS\u548cDEGREE\u7684\u7b5b\u9009\u673a\u5236\u548c\u6548\u679c\uff1a<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
DEGREE<\/h5>\n\n\n\n

\u5728\u751f\u7269\u5b66\u672f\u8bed\u4e2d\uff0c\u5ea6\u8bc4\u4f30\u8282\u70b9\u7684\u8c03\u63a7\u76f8\u5173\u6027\u3002\u5728\u4fe1\u53f7\u7f51\u7edc\u4e2d\uff0c\u5ea6\u975e\u5e38\u9ad8\u7684\u86cb\u767d\u8d28\u4e0e\u591a\u4e2a\u5176\u4ed6\u4fe1\u53f7\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff0c\u6697\u793a\u8be5\u86cb\u767d\u8d28\u662f\u4e00\u4e2a\u4e2d\u5fc3\u8c03\u63a7\u89d2\u8272\uff0c\u5373\u5b83\u53ef\u80fd\u662f\u8c03\u63a7\u7684\u201c\u67a2\u7ebd\u201d\u3002 <\/p>\n\n\n\n

CLOSENESS<\/h5>\n\n\n\n

\u5728\u751f\u7269\u7f51\u7edc\u5982\u86cb\u767d\u8d28\u4fe1\u53f7\u7f51\u7edc\u4e2d\uff0c\u63a5\u8fd1\u4e2d\u5fc3\u6027\u53cd\u6620\u4e86\u86cb\u767d\u8d28\u4e0e\u5176\u4ed6\u86cb\u767d\u8d28\u529f\u80fd\u76f8\u5173\u7684\u6982\u7387\u3002\u5177\u6709\u9ad8\u63a5\u8fd1\u4e2d\u5fc3\u6027\u7684\u86cb\u767d\u8d28\u53ef\u80fd\u4f5c\u4e3a\u8c03\u63a7\u4e2d\u5fc3\uff0c\u4f46\u4e5f\u53ef\u80fd\u5bf9\u67d0\u4e9b\u86cb\u767d\u8d28\u7684\u6d3b\u52a8\u6ca1\u6709\u5f71\u54cd\u3002\u540c\u65f6\uff0c\u4f4e\u63a5\u8fd1\u4e2d\u5fc3\u6027\u7684\u86cb\u767d\u8d28\u53ef\u80fd\u4f5c\u4e3a\u7f51\u7edc\u95f4\u7684\u8fde\u63a5\u70b9\u3002<\/p>\n\n\n\n

BETWEENESS<\/h5>\n\n\n\n

\u5728\u751f\u7269\u7f51\u7edc\u5206\u6790\u4e2d\uff0cS.-P. \u4ecb\u6570\u4e2d\u5fc3\u6027\u53ef\u4ee5\u7528\u6765\u8bc4\u4f30\u86cb\u767d\u8d28\u5728\u4fe1\u53f7\u4f20\u9012\u4e2d\u7684\u4f5c\u7528\u3002\u5177\u6709\u9ad8S.-P. \u4ecb\u6570\u4e2d\u5fc3\u6027\u7684\u86cb\u767d\u8d28\u53ef\u80fd\u5728\u7ec4\u7ec7\u548c\u8c03\u8282\u5206\u5b50\u95f4\u7684\u901a\u4fe1\u4e2d\u626e\u6f14\u5173\u952e\u89d2\u8272\uff0c\u5b83\u4eec\u80fd\u591f\u5c06\u8fdc\u8ddd\u79bb\u7684\u86cb\u767d\u8d28\u8fde\u63a5\u8d77\u6765\uff0c\u5bf9\u4e8e\u7ef4\u6301\u4fe1\u53f7\u673a\u5236\u7684\u529f\u80fd\u548c\u4e00\u81f4\u6027\u81f3\u5173\u91cd\u8981\u3002\u56e0\u6b64\uff0c\u8fd9\u79cd\u4e2d\u5fc3\u6027\u6307\u6807\u6709\u52a9\u4e8e\u8bc6\u522b\u5728\u751f\u7269\u8fc7\u7a0b\u4e2d\u8d77\u6838\u5fc3\u4f5c\u7528\u7684\u86cb\u767d\u8d28\u3002<\/p>\n\n\n\n

\u5c0f\u679c\u4e00\u822c\u4f7f\u7528degree\u3001closness\u548cbetweenness\u4e09\u4e2a\u56e0\u7d20\u8fdb\u884c\u7b5b\u9009\uff0c\u8fd9\u4e09\u4e2a\u56e0\u7d20\u7b5b\u9009\u51fa\u6765\u7684\u86cb\u767d\u5927\u6982\u7387\u662f\u4e2d\u5fc3\u8c03\u63a7\u89d2\u8272\uff0c\u4e0e\u5176\u4ed6\u86cb\u767d\u7684\u529f\u80fd\u8868\u8fbe\u5bc6\u5207\u76f8\u5173\u3002\u8fd9\u91cc\u5c0f\u679c\u4e5f\u62ff\u8fd9\u4e09\u4e2a\u56e0\u7d20\u4f5c\u4e3a\u793a\u8303\u6765\u544a\u8bc9\u5927\u5bb6\u5982\u4f55\u7b5b\u9009\u9776\u70b9\u57fa\u56e0\u3002<\/p>\n\n\n\n

\u7b5b\u9009\u5b8c\u6bd5\u540e\u5728\u754c\u9762\u7684\u53f3\u8fb9\u4f1a\u663e\u793a\u51fa\u7b5b\u9009\u7684\u7ed3\u679c\u9762\u677f\uff0c\u6211\u4eec\u628a\u5b83\u89e3\u9664\u56fa\u5b9a\u540e\u653e\u5927\u6765\u67e5\u770b\u7b5b\u9009\u7684\u6570\u503c\uff1a<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u7b5b\u9009\u7ed3\u675f\u540e\u53f3\u4e0b\u89d2\u663e\u793a\u4e86\u5f97\u5230\u7684\u53c2\u6570\uff0c\u6211\u4eec\u70b9\u51fb\u53f3\u4fa7\u4e2d\u95f4\u680f\u6700\u53f3\u8fb9\u7684\u6309\u94ae\u5c06\u5176\u5bfc\u51fa\u5230excel\u4e2d<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u53ef\u4ee5\u770b\u5230\u76ee\u524d\u6709225\u4e2a\u8282\u70b9\uff0c\u7136\u540e\u6211\u4eec\u6839\u636e\u7ed3\u679c\u9762\u677f\u9608\u503c\uff08threshold\uff09\u7684\u503c\u5728excel\u4e2d\u8fdb\u884c\u7b5b\u9009<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u5bf9\u4e09\u5217\u90fd\u7b5b\u9009\u5b8c\u6bd5\u540e\u8fd8\u526944\u4e2a\u8282\u70b9\uff08\u89c1\u5de6\u4e0b\u89d2\u53ca\u53f3\u4e0b\u89d2\uff09<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u6211\u4eec\u5728filter\u4e2d\u65b0\u5efa\u4e09\u4e2acolumn filter\uff0c\u968f\u540e\u9009\u62e9\u6211\u4eec\u7b5b\u9009\u7684\u4e09\u4e2a\u53c2\u6570\u5e76\u5c06\u9608\u503c\u8f93\u5165\u8fdb\u53bb\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u7531\u4e8e\u6211\u4eec\u7684\u9608\u503c\u4e3a\u6700\u5c0f\u503c\uff0c\u5373\u6211\u4eec\u60f3\u8981\u5f97\u5230\u7684\u6570\u636e\u5e94\u8be5\u4e3a\u5927\u4e8e\u7b49\u4e8e\u8be5\u9608\u503c\u7684\u6570\u636e\uff0c\u5219\u6211\u4eec\u5c06\u9608\u503c\u4f5c\u4e3a\u6700\u5c0f\u503c\u8f93\u5165\u8fdb\u53bb\u540e\u5f97\u5230\u7684\u5373\u4e3a\u6211\u4eec\u4e0d\u9700\u8981\u7684\u6570\u636e\uff0c\u5168\u90e8\u8f93\u5165\u5b8c\u6210\u540e\u9ec4\u8272\u7684\u5373\u4e3a\u7b5b\u9009\u51fa\u5c0f\u4e8e\u9608\u503c\u7684\u9776\u70b9\uff0c\u4f7f\u7528\u9f20\u6807\u53ef\u4ee5\u62d6\u52a8\uff0c\u5c06\u5176\u76f4\u63a5\u5168\u90e8\u5220\u9664\u540e\u5269\u4f59\u7684\u5373\u4e3a\u7b26\u5408\u6211\u4eec\u8981\u6c42\u7684\u9776\u70b9\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u8fd9\u91cc\u5c0f\u679c\u63d0\u9192\u5927\u5bb6\uff0c\u8981\u517b\u6210\u968f\u65f6\u8bb0\u5f55\u7684\u597d\u4e60\u60ef\u54e6\u3002\u4ee5\u5c0f\u679c\u7684\u6570\u636e\u4e3a\u4f8b\uff0c\u5728\u521a\u5bfc\u5165CYTOSCAPE\u65f6\u662f225\u4e2a\u8282\u70b9\u548c4464\u6761\u8fb9\uff0c\u7b5b\u9009\u6761\u4ef6\u4e3acloseness\u5927\u4e8e0.002334653906034231\uff0cbetweenness\u5927\u4e8e213.02222222221678\uff0cdegree\u5927\u4e8e39.68\u3002\u7b5b\u9009\u540e\u5269\u4f5944\u4e2a\u8282\u70b9\uff0c829\u6761\u8fb9\u3002<\/p>\n\n\n\n

\u5c0f\u679c\u5148\u5c06\u8282\u70b9\u4eec\u6309\u7167\u5706\u5f62\u6392\u5217\uff0c\u8fd9\u6837\u65b9\u4fbf\u6211\u4eec\u89c2\u5bdf\uff0c\u64cd\u4f5c\u5982\u4e0b\u56fe\u6240\u793a\uff1a<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

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\"\"<\/figure>\n\n\n\n

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